Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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matrix metallopeptidase 9(MMP9) matrix metallopeptidase 9(MMP9) Related Genes Homo sapiens
CHROMOSOME 20,
CYTOBAND 20q11.2-q13.1,
ENSEMBL_GENE_ID ENSG00000100985,
GENERIF_SUMMARY involvement of MMPs in microinvasive carcinomas, 125-kDa urinary gelatinase as being a complex of MMP-9 and NGAL and provides evidence that NGAL modulates MMP-9 activity by protecting it from degradation., secretion in primary human monocytes induced by chemokines, Significant association with poor survival by MMP-9., results indicate that two kinds of pro-form and active-form matrix metalloproteinases, MMP-2 and MMP-9, and their degradation products, are present in human seminal plasma, Multiple signaling pathways involved in activation of matrix metalloproteinase-9 in breast cancer cells, The CC chemokines CCL2 (MCP-1), CCL3 (MIP-1alpha), and CCL5 (RANTES) stimulated the release of monocyte MMP-9 protein in a bell-shaped dose-dependent manner., Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression., overexpression of MMP-9 in HTLV-I- infected cells may be in part responsible for the invasiveness of adult T-cell leukemia cells., in differentiating trophoblasts Nitric Oxide regulates the induction of MMP-2 and MMP-9 required for invasion during embryo, shed as membrane vesicle associated components by endothelial cells and this may be a mechanism for regulating focalized proteolytic activity vital to invasive and morphogenic events during angiogenesis, gelatinolytic activity in situ, in tissue sections of term placenta, is co-localized with gelatinase B, in pancreatic cancer, invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion., MMP-9 activity is significantly elevated in SLE patients and correlated with disease activity in males but not females. These results suggest that MMP-9 plays a role in the pathogenesis of SLE., Respiratory syncytial virus infection of HEp-2 cells induces matrix metalloproteinase-9 expression, C/C homozygosity at the C-1562T polymorphism of the promoter may be protective against coronary artery disease in Koreans., increasing expression and endometrial carcinoma appear closely related, significantly increased activity seen in plasma of head and neck squamous cell carcinoma patients, activity significantly higher in lung cancer cells than uninvolved lung parenchyma; may be involved in tumor progression, The expression of MMP-9 was significantly increased in mesangial proliferative glomeruli and interstitial vascular walls of IgA nephropathy patients., expression of MMP-9 in cervical cancer, The plasma MMP-9 levels in patients with HCC were significantly higher than those in the normal controls, Results suggest that gastrin increases MMP-9 expression, which is associated with increased invasion, and this is a putative mechanism regulating remodelling of the gastric epithelium., Production of matrix metalloproteinase-9 in early stage B-CLL is suppressed by interferons alpha and gamma., We have determined the functional significance of a variable number tandem repeat and a single nucleotide polymorphism (SNP) in the MMP-9 gene on promoter activity and their association with preterm premature rupture of membranes (PPROM)., REVIEW, novel regulation for the proteolytic activation of MMP-9 in human tissue (tissue-associated chymotrypsin-like proteinase, pM9A)., Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients., destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells., ox-LDL and HDL lipoproteins regulate the production by activated monocytes, Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor, FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway., signalling pathways involved in MMP-9 regulation at the maternal-fetal interface, roughly constitutive TIMP-1 expression opposed to an inducible MMP-9 synthesis in Epstein--Barr virus-immortalized B lymphocytes, The X-ray crystal structure of the proform of human matrix metalloproteinase MMP9 has been solved to 2.5 A resolution, evaluation of the effect of increased levels of active MMP-9 in the central nervous system, Expression of MMP9 is elevated during PBSC mobilization by G-CSF., Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B, structural basis of the adaptive molecular recognition by MMP9, No allelic associations have been found between multiple sclerosis and the CA microsatellite marker in the promoter region of the gelatinase B gene in Belgian study populations., plasma levels are increased during G-CSF induced hematopoietic stem cell mobilization, data indicate the involvement of matrix metalloproteinase 2 and matrix metalloproteinase 9 in the cervical ripening, role of MMP9 in aortic aneurysms, Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production., Primary GBMs were significantly more likely than secondary GBMs to contain active MMP-9. Active MMP-9 expression occurred in 83% of the EGFRvIII-immunopositive tumors only., Hyaluronan-CD44 interaction inhibits migration of osteoclast-like cells by down-regulating MMP-9., MMP9 activation is increased by Eph B4 receptor stimulation in human cells, mmp-9 production in bronchial epithelial cells is inhibited by S-nitrothiols, Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement, MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD, Block of mmp9 induction via vegfr-1 inhibition could be useful for the prevention of tumor metastasis in lung., PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation., MMP-9 expression showed a tendency toward an adverse outcome of Hodgkin's lymphoma, MMP9 expression is regulated by MTA1 via histone-dependent and independent mechanisms in human cells, ILK activity is aassociated with upregulation of MMP-9 mRNA levels during podocyte stress, thrombospondin-1 plays a role in the up-regulation of MMP-9 expression in gastric cancer, data indicate that matrix metalloproteinase-9 is produced by the amnion but not the chorion in response to lipopolysaccharide; tumor necrosis factor-alpha and interleukin-1 beta appear to upregulate its production by the amnion, The expression of MMP-9 was positively related to the tumor invasiveness and metastasis in gastric cancers, HBV infection of hepatocytes and HepG2 cells affected the upregulation of MMP-9 expression and MMP-9 activation and, increased the invasion potential by plasmin, this is a report showing that an HBV infection is linked to the upregulation of MMP-9 in HCC, MMP-9 plays an important role in inflammatory peripheral neuropathy probably as means for inflammatory cell invasion, The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix., Increase of CD44s, MMP-9, and Ki-67 were involved in the growth and local invasion of osteosarcoma., data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein, Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen, matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis, MMP-9 may contribute to eosinophil and mast cell migrations into nasal polyp tissue., Arfaptin 1 inhibits ADP-ribosylation factor-dependent secretion of this enzyme induced by phorbol ester in fibrosarcoma cells., significant increase of MMP-9 and TIMP-1 in the urine of children with acute pyelonephritis., In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower., elevated pro-MMP-9 enzyme during the acute phase of Kawasaki disease may reflect vascular remodeling or an inflammatory response to a microbial agent, suggesting a pathophysiological role for MMP-9 in coronary aneurysm formation., triple-helical peptides are highly selective substrates for and are hydrolyzed by human MMP2 and MMP9, not expressed by intestinal myofibroblasts in inflammatory bowel disease., Membrane-bound MMP-9 on PMN may play pathogenetic roles in inflammatory lung diseases, MMP-9 induction by H. pylori may play an important role in gastric inflammation, ulcer formation, and carcinogenesis., The purpose of this study was to evaluate the roles of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA) with regard to varicose veins (VVs)., Chorioamnionitis is associated with increased lung type IV collagenase levels in the ventilated preterm infant. Antenatal lung inflammation with up-regulation of MMP-9 may be important in the pathogenesis of chronic lung disease., MMP9 is activated through an oxidative pathway in pneumococcal meningitis, The interaction between MMP-9 and TIMP-1 in the processes of gastric tumor invasion and metastasis is that MMP-9 mainly promotes tumor invasion and metastasis and TIMP-1 inhibits functions of MMP-9., matrix metalloproteinase-9 activation and association with integrin are inhibited by ganglioside GM3, Data demonstrate that blockade of the ERK pathway suppressed the expression of matrix metalloproteinases 3, 9, and 14, and CD44, and markedly inhibited the invasiveness of tumor cells., Polymorphisms of the matrix metalloproteinase-9 gene influences the development of coronary artery disease., Requirement for PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells., MMP-9 plasma level was significantly higher in patients undergoing thrombolytic therapy whose arteries were not recanalized; MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus, MMP-9 and LM-R are useful indexes for predicting the metastasis and prognosis of breast cancer., MMP9 is activated by SDF1 in bone marrow cells, causing release of soluble Kit-ligand and transfer of hematopoietic stem cells from a quiescent to a proliferative niche, Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9, PBMCs from SLE patients expressed a significantly higher activity of MMP-9 and spontaneously released higher levels of MMP-9, as compared to healthy donors, NF kappa B plays a in the regulation of MMP-9 expression and the ability of dykellic acid to suppress phorbol myristate acetate induction of MMP-9, with decreased MMP-9 promoter activity and mRNA expression., results strongly support that sTNF up-regulates in an autocrine manner PAI-1 and MMP-9 syntheses during promyelocyte to monocyte differentiation; in more advanced differentiated stages, released sTNF is not a major determinant of PAI-1 and MMP-9 syntheses, a negatively charged peptide motif within the catalytic domain of MMP9 mediates binding to leukocyte beta 2 integrins, 2.2 kb of the promoter region and all 13 exons (3.3 kb) of MMP9 genomic DNA were scanned for polymorphisms. There is a possible role for the (CA)n repeat in renal disease., proMMP-9 has a novel role in providing a cellular switch between stationary and migratory cell phases, vascular endothelial growth factor and matrix metalloproteinase-9 expression in osteolytic lesions of bone co-relates well with the extent of bone destruction and local recurrence, MMP-9 released from neutrophils may be involved in the pathogenesis of bronchial asthma and COPD., HGF, SDF-1, and MMP-9 have roles in stress-induced human CD34+ stem cell recruitment to the liver, high levels of plasma MMP-9 activity is associated with evidence of recurrence in breast cancer, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, Ultraviolet A downregulates MMP-9 in keratinocytes., MMP-9 may not only play a role in the pathogenesis of COPD, but also relate to FEV(1.0)% of prediction and RV/TLC%., GDNF upregulates expression and enzymatic activity of MMP-9 through different signaling pathways. GDNF modulates MMP-9 expression and activation, and this may promote pancreatic cancer invasion., Upregulation of mmp-9 ia assiciated with neoplasm invasiveness in Hereditary nonpolyposis colorectal cancers, The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA, oxidative stress-dependent MMP-9 induction in brain capillary endothelial cells was accompanied by a significant increase in the NF-kappaB localized in the nuclei, monocyte matrix metalloproteinase-1 and -9 are differentially regulated by interferon gamma through tumor necrosis factor-alpha and caspase 8, Data show that tissue plasminogen activator upregulates matrix metalloproteinase-9 in cell culture and in vivo, and that this is mediated by the low-density lipoprotein receptor-related protein., Both active gelatinases were detected in tears of severe corneal ulcer or severe ocular burn cases. The active form of gelatinase expression may be related to the severity of ulceration., palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours, MMP9 plays a role in the release of biologically active VEGF and consequently in the formation of ascites in ovarian cancer., Increased plasma MMP-9 is associated with colorectal cancer, gelatinase B and neutrophil collagenase cleave MIG and IP-10, specific up-regulation of MMP-9 in the erythema migrans skin lesions of patients with acute Lyme disease; may play a role in the dissemination of B. burgdorferi., an overview of mmp-9 gene expression in different cell types, from the triggering of cell-surface receptors, to the activation of cytoplasmic mediators and transcription factors responsible for the activation of MMP-9 promoter--REVIEW, Induction of MMP-9 secretion is related to the inflammation including apoptosis of keratinocytes resulting from UVB irradiation., Although MMP-9 level predicts parenchymal brain hemorrhages after tPA treatment, no relationship exists with the C-1562T polymorphism, probably because this mutation is not functional in response to cerebral ischemia in vivo, MMP-9 within tuberculous granuloma is associated with tissue destruction; monocytic cells packed together at the center of tuberculous granuloma exhibit strong cytoplasmic staining for MMP-9, but not TIMP-1., first report to show that cultured HUVE constitutively express MMP9 and that this secretion is restricted to very early-passage cells, Plasma MMP-9 concentrations decrease aafter insulin infusion., RhoA induced the expression of MMP-9; clustering of MMP-9 was observed in advancing lamellipodia at the forefront of endothelial cells, where this proteinase colocalized with RhoA and CD44, MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential in cancer., effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts, MMP-9 and su PAR levels might be used as a marker for disease activity and may contribute to blast cell dissemination. MMP-9 and suPAR may be target molecules in the strategy of treatment of AML., in wounded keratinocytes, upregulation of matrix metalloproteinase-9 depends on two distinct pathways, Data show that matrix metalloproteinase-9 expression in human lung parenchyma is associated with cigarette smoking and with obstruction of airflow, suggesting that MMP-9 may play a role in the pathogenesis of COPD., The analysis of MMP-9 in synovial fluid samples can reveal the inflammatory condition of the knee joints with gouty arthritis, Serum MMP-9 does not relate to the late phase of hepatic ischmeic reperfusion injury after human orthotopic liver transplantation., stimulated expression of MMP-1 and MMP-9 may contribute to the invasive activity and the bone and cartilage loss in pigmented villonodular synovitis, The presence of MMP-9 was found in endometrial cancer, correlating with estrogen receptor alpha and uteroglobin levels., MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells., MMP-9 release from eosinophils is regulated by signaling through p38 MAP kinase, The -1562C-->T polymorphism of matrix metalloproteinase-9 was associated with bone mineral density in Japanese men, MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates, Various growth factors induce migration of human non-small cell lung cancer cells in the presence of extracellular matrix (ECM) components MMP-2 and MMP-9., polymorphism in the promoter region may not have a relationship with implant loss, MMP-9 seems to be involved in ischemia/reperfusion injury during human liver transplantation, downregulated by Cytomegalovirus IL-10 activity in uterine microvascular endothelial cells and differentiating-invading cytotrophoblasts, the coordinated modulation of MMP-9 transcription via the TRE and the KRE-M9 elements is important in epidermal and mesenchymal tissues., MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential., Elevated serum MMP-9 in systemic lupus erythematosus may reflect neuropsychiatric involvement, particularly cognitive dysfunction. Serum MMP-9 concentration may be associated with small-vessel cerebral vasculopathy and risk of cerebral ischemia., MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral squamous cell carcinoma, MMP-9 may have a role in the higher migrational capacity of CB CD34(+) cells, which may be beneficial to homing of these cells to the BM environment., Nitric oxide concentrations could impact on capillary formation via a combination of direct effects on MMP activation and by altering the distribution or abundance of Cav-1 in tumor angiogenesis., MMP-2 or MMP-9 mediated tumor cell invasion requires integrin cytoplasmic-tail motif EKQKVDLSTDC, cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1 in first trimester decidua, membrane location can influence MMP9 activity in vitro and in vivo, and confirmation of the relevance of stromal-associated, but not tumor-bound MMP9 in mediating tumor-induced angiogenesis, sICAM-1 was processed distal to Arg441, indicating that MMP-9, docking to ICAM-1, contributes to sICAM-1 shedding and attenuation of the shear stress-induced upregulation of ICAM-1., Endometriosis-associated increase in proteolysis and imbalance between of MMP-9 and of TIMP-1 in culture medium of endometrial tissue may reflect in vivo enhanced capacity of this tissue to break down the extracellular matrix in host tissues., MMP-9 was increased regionally in the infarct-related coronary artery, at 11.8 ng/ml vs 8.2 ng/ml in the ascending aorta (p<0.001)., RNAi inhibits MMP9 gene expression in a glioblastoma cell line., Results define molecular details for several interactions mediated by the different MMP-9 domains, using specific MMP-9 peptide inhibitors., Data suggest that MMP-9 has a role in tumor progression of head and neck carcinomas, as well as in estimation of the prognosis of these diseases., HBx contributed to MMP-9 transcriptional regulation through the ERKs & PI-3K-AKT/PKB pathway. Enhanced expression of MMP-9 by activation of these signals is eventually associated with the invasive potential of cells., Helicobacter pylori infection results in substantially increased in the gastric mucosa, probably contributed to in large part by tissue-resident macrophages, coordination of cell signaling, chromatin remodeling, histone modifications, and stepwise recruitment of transcription regulators is critical to precisely regulate MMP-9 gene transcription in a temporally and spatially dependent manner, The MMP-9 C-1562T promoter polymorphism genotype is associated with large artery stiffening and aortic MMP-9 gene & protein expression, increasing susceptibility to myocardial ischemia., Active involvement of MMP-2 and -9 in end-stage liver disease and orthotopic liver transplantation., results present proMMP-9 as a novel early indicator of acute host-response in pleural space that complements traditional proinflammatory markers and might be useful in monitoring pleural inflammatory processes, Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade., RAGE and MMP-9 are expressed concordant with metastatic ability of human pancreatic cancer cells., results suggest that matrix metalloproteinase-9 and matrix metalloproteinase-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling, MMP-9 expression is inhibited by CIITA by binding to and sequestering CREB-binding protein, marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women, EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck, An intense expression of VEGF and MMP-9 in carotid plaques is related to plaque instability, high degree of stenosis and presence of symptomatic carotid occlusive disease., a mechanism for ROS function in Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell MMP2 and MMP9 during VCAM-1-dependent lymphocyte migration, Streptococcus pyogenes SpeB activates proMMP-9 with subsequent release of proapoptotic TNF-alpha and sFasL leading to apoptosis, tissue damage and streptococcal invasion in the host., Plasma levels are increased in type 2 diabetic patients., collagen type II immunodominant epitopes remain intact after cleavage by gelatinase B and may become available, processed as antigens and presented in MHC-II molecules, HBV affects the malignance of hepatocellular cancer by elevating MMP-9 activity., Different regulatory mechanisms of MMP-9 production and/or activity between primary progressive/transitional progressive and relapsing-remitting multiple sclerosis., RECK/MMP-9-balance is an informative prognostic indicator for colorectal cancer., Overexpression of matrix metalloproteinase 9 is associated with prostate cancer, Circulating pretreatment MMP-9 and TIMP-1 levels were significantly higher in patients with hypertension, Both MMP-9 and TIMP-1 levels were higher in the hypertensive group, In patients with recurrent ovarian cancer the activated forms of MMP-9 were significantly higher compared to ovarian cancers without recurrence., Fusobacterium nucleatum subsp. nucleatum increases its tissue-invasive potential by acquiring cell-associated human matrix metalloproteinase 9 (MMP-9) activity, Increased gelatinase in culture medium of toxic epidermal necrolysis or Stevens-Johnson syndrome skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for detachment of epidermis in these diseases., length alteration of the d(CA) repeat in the MMP-9 promoter may cause phenotypic differences among HTLV-I infected infiltrating cells and may thereby be in part responsible for the development of HTLV-1 associated myelopathy (HAM/TSP)., CDK9 mediates TNF-alpha-induced MMP-9 transcription, Acrolein, a constitutent of cigarette smoke, increases expression of MMP9 in airway epithelial cells, Arsenic trioxide directly downregulates radiation-induced MMP-9 mRNA expression by inhibiting nuclear factor kappaB activity in human cervical cancer cells., Endometrial MMP-9 activity is overall controlled by the ovarian steroids and locally adjusted through a network of modulators, including LEFTY-A., The Matrix Metalloproteinase-9 was expressed of cultured human uveal melanocytes, and analysis revealed the Matrix Metalloproteinase-9 mRNA., may be involved in the process of arterial stiffening and development of isolated systolic hypertension, The expression of MMP-9, TIMP-1 and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones., Our results indicate that the T allele in the MMP-9 promoter is associated with the invasive phenotype of gastric cancer., Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2, MMP9 is expressed in the unstable coronary atherosclerotic plaque, as are its transcriptional and posttranscriptional regulators, MIF and MMP-9 are markedly upregulated in vulnerable atheromatous plaques. The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques., In melanoma cells microtubule-dependent traffic of MMP2/MMP9-containing vesicles and exocytosis are critical steps for invasive behavior., breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes., secreted pro-MMP-2 and pro-MMP-9 are downregulated by farnesyltransferase inhibitors in carcinoma cells, Expression in colorectal carcinomas relating to size and invasiveness of the tumor., Enhanced production of MMP-9 may contribute to fibrogenic remodeling during the progression of skin sclerosis in systemic sclerosis., Increase of pro-MMP-9 circulating in the blood of amyotrophic lateral sclerosis (ALS) patients may link to a primary pathogenetic mechanism, while elevated pro-MMP-9 levels may also rise as a consequence of secondary nerve and muscle damage in ALS., MMP-9 was only expressed when lung fibroblasts were grown on collagen type IV and increased with serum concentration, and by hypoxia, Over expression of MMP-9 is associated with nonsmall cell lung carcinoma progression, Overexpressing functional TIMP-1- enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9., vascular MMP-9 expression may play a role in the pathogenesis of spontaneous intracerebral hemorrhage--REVIEW, Treatment of THP-1 cells with recombinant TL1A in combination with IFN-gamma also caused induction of MMP-9 and interleukin-8, altered MMP/TIMP ratios in maternal blood during gestational hypertension, This is the first demonstration that Akt is involved in the signaling pathway leading to the production of monocyte MMP-9, serum amyloid A plays a role in the modulation of inflammatory and immune responses via formyl peptide receptor like 1, by inducing MMP-9 upregulation, Hypoxia induces an increased invasive capacity via gelatinase up-regulation without loss of cell viability in adenocarcinomas, the particular combination of MMP3 and MMP9 genotypes present at susceptibility loci may contribute to heterogeneity in the presentation of atherosclerosis., uPAR and MMP-9 have roles in inhibiting cell proliferation and can reduce the levels of phosphorylated forms of MAPK, ERK, and AKT signaling pathway, MMP-9 is increased in tuberculous pleural effusions compared with transudates and malignant pleural effusions of lung cancer and is produced predominantly by epithelioid cells in the granulomas of tuberculous pleural tissues., indicate that there is a positive correlation between n-3 docosapentaenoic acid and MMP-9, IL-8-induced MMP-9 release from neutrophils is mediated through CXCR2 and involves two distinct pathways, one involving PKC and ERK1/2 and the other involving Src-family kinases, NF-kappaB-dependent MMP-9 plays a key role in Platelet-activating factor-induced angiogenesis, MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk., MMP-9 activity is inhibited by ascochlorin through suppression of AP-1-dependent induction of MMP-9 gene expression, expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes., Migration of CD4+ T cells is dependent on MMP9 expression; T-helper type 2 (Th2) cells secrete lower levels of MMP9 and have less migratory capacity in comparison to Th1 cells., Significantly elevated metalloproteinase 9 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans, MMP-9/tissue inhibitor of metalloproteinase 1 system and beta-chemokines could cooperate in conditions of elevated oxidative stress, which ultimately predisposes hemodialysis patients to accelerated atherosclerosis, expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells, MMP9 plays a key role in the onset of labor, maturation and dilatation of uterine cervix., HIF-1alpha and CA IX, but not VEGF or MMP-9, may have a role in progression of surgically resected non-small cell lung cancer, MMP-9 and MMP-13 are involved in stroke progression and the neuroinflammatory response, Findings suggest that the genetic polymorphism in MMP-9 promoter (C-1562-T) is associated with the susceptibility to acute coronary syndrome in the Han population of China., MMP-9 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases., relaxin-induced MMP-9 expression in THP-1 cells involves NF-kappaB activation, MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing in giant cell arteritis, MMP9 levels are not significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations., hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues; possible role of hemoglobin in joint damage after intra-articular bleeding, MMP-9 might not be a major gene for branchial asthma, MMP-9/TMIP-1 ratio may be viewed as a reliable marker and may be predictive of MRI activity in relapsing recurring multiple sclerosis in Avonex treatment., These data suggest that elevated leukocyte matrix metalloproteinase-9 may contribute to the pathogenesis of type I diabetes and its associated complications., NGAL may play an important role in breast cancer in vivo by protecting MMP-9 from degradation, thereby enhancing its enzymatic activity and facilitating angiogenesis and tumor growth, the potentially functional polymorphisms MMP-9 P574R and R279Q, may have a role in occurrence and metastasis of primary lung cancer, Serum levels of MMP-9 and Fib were independent risk factors of acute coronary syndrome. No significant difference between controls and ACS patients was found in the frequencies of MMP-9 C-1562T and G5564A genotypes., The most invasive cell line secreted the highest amounts of MMP-2 and MMP-9., Although MMP9 may potentially promote tumor growth and metastasis, production of MMP-dependent anti-angiogenic factors seems to override these effects and protects the host from NSCL growth and progression, MMP9 immunoreactivity was present in polymyositis, dermatomyositis and focal myositis, Therefore, the inhibition of MMP-9 expression by curcumin might have therapeutic potential for controlling the growth and invasiveness of brain tumor., exogenous CXCL12 induced MMP-9 expression in prostate cancer and bone metastasis., Polymorphism of MMP-9 (C-1562T) was associated with upper lung dominant emphysema in patients with COPD., High MMP-9 expression is associated with recurrent liver or lung tumors of colorectal cancer, MMP9 in human blood originating from neutrophils is increased by S. aureus peptidoglycan, Our results demonstrate that SM-7368 is a synthetic compound that inhibits TNF-alpha-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-alpha-mediated tumor invasion and metastasis., findings indicate differences in early matrix metalloproteinase 9 (MMP-9) bronchoalveolar lavage fluid levels between resolving respiratory distress syndrome and developing chronic lung disease of prematurity, The expression of MMP9 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain., the high number of CA repeats in MMP-9 promoter is positively correlated with faster intima media thickening and constrictive remodeling of atherosclerosis, Runx2-regulated MMP9 levels are functionally related to the invasion properties of cancer cells, Expression and secretion of the matrix metalloproteinase 9 (MMP-9) in macrophages is induced by lipomannans through a toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism., In acute stage of Kawasaki disease, serum MMP-9 level and the ratio of MMP-9/TIMP-1 were higher in patients with coronary artery lesion than those in patients without CAL., Suppression of MMP-9 by dinoprostone in peritoneal macrophages is associated with severity of endometriosis., Enhanced expression and potentially increased activity of LV myocardial MMP-9 triggers the signal cascade instigating cardiac remodeling., Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-9 is expressed in all of the cysts, With tumor progression and development of heterogeneity, the abnormal expressions of MMP-9, TIMP-2, and E-cadherin or DNA aneuploid rate or high SPF gradually increases, suggesting that they play a crucial role in gastric carcinoma progression, utility of expression cloning in identifying specific regulators of MMP-9 expression (review), In chronic rhinosinusitis and nasal polyps tissues the expression of TGF-beta1, MMP-7, MMP-9, TIMP-1 protein was significant increased compared to controls., There was a significant positive correlation between the expression of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma., FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase, Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-9 is associated with breast cancer, trophozoite-parasitized RBCs/hemozoin-fed adherent human displayed increased MMP-9 activity and protein/mRNA expression, Homozygous familial hypercholesterolemia patients exhibited significantly elevated level of active MMP-9., Platelet-activating factor-induced MMP-9 expression, in a NF-kappaB-dependent manner, is regulated by Ca(2+), PI3K and ERK signaling pathways., The proteolytic activation of pro-MMP-9 in skin inflammatory diseases likely occurs via a pathway including IL-1alpha., Results suggest that MMP-9 might contribute in the pathogenesis of chronic kidney disease., activation of MMP-13 as well as MMP-9 induced by H-Ras is involved in angiogenesis and with farnesyl transferase inhibitors, in part, exerts their anticancer effects, Obese women with polycystic ovary syndrome have elevated serum concentrations of MMP-9., variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity, The active MMP-1 and MMP-9 plasma levels were found to vary in the menstrual cycle., During exacerbation, increased inflammatory burden coincides with an imbalance of the proteinase MMP-9 and its cognate inhibitor TIMP-1, One polymorphism was associated with chronic obstructive pulmonary disease in a cohort of veterans., MMP-9 and MMP-2 are mediators of inflammation in chronic otitis media with effusion, peripheral blood MMP-9 levels might serve as surrogate biomarkers of retinopathy in type 1 diabetic patients free of other vascular complications, MMP-9 is an important member of the matrix metalloproteinase (MMP) family that participates in remodeling of extracellular matrix during tooth development. Data suggested that MMP-9 gene promoter polymorphism was not associated with hypodontia., A localized increase in MMP-8 and -9, mediated by native mesenchymal cells, presents a potential pathway for collagen breakdown and abdominal aortic aneurysm rupture., The MMP-9 1562C/T polymorphism may not be associated with occurrence of endometriosis and adenomyosis in women from North China., RECK gene could inhibit the expression of MMP-9 in hilar cholangiocarcinomas., MMP-9 plays an important role in the vascular destruction of Henoch-Schonlein purpura, and circulating white blood cells may be a source of the MMP-9 secreted into the circulation.may be a source of the MMP-9 secreted into the circulation., p70S6K activation induces expression of MMP-9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells, MMP-9 was increased in anterior wall of thoracic aortic aneurysms., it is reported here that ECM1 interacts with MMP9 and that such interactions diminish the proteolytic activity of MMP9, a novel role for P2X(7) as a pro-inflammatory receptor involved in rapid MMP-9 release and leukocyte recruitment., We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression., study indicates that the expression of MMP-9 is up-regulated in a stepwise fashion, with two main steps, the first one, when a laryngeal dysplastic lesion evolves and the next one, when the dysplasia progresses to invasive laryngeal carcinoma, Overexpression of stromal MMP-9 is independently associated with shorter disease-specific survival in epithelial ovarian cancer., Number of repeats (> or =22 CA) in microsatellite of MMP-9 promoter, but not MMP-9 plasma levels, is associated to carotid atherosclerosis and particularly to plaques with thin fibrous cap., potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-9 was reduced in women with menorrhagia, Increased matrix metalloproteinases 9 level is associated with high-grade and advanced-stage bladder tumors, protein expression levels of pro- & active MMP-9 were higher in colorectal tumor tissues than in the corresponding normal tissues., Higher MMP9 activity is associated with breast cancer, first demonstration that Cited2 functions as a Smad3/p300-interacting transcriptional co-activator in modulating the expression of MMP9, which could affect tumor cell invasion mediated by TGF-beta, 17 polymorphisms associated with the risk of childhood atopic asthma were identified in MMP-9., A coding SNP (Q279R in exon 6) within the MMP9 gene to be associated with a lowered risk of trachomatous scarring and trichiasis., REVIEW. MMP-9 plays either a primary or secondary role in autoimmune diseases by its up or down-regulation., A model of costimulation of chemokine receptor signaling in interferon-alpha dendritic cells is proposed for MMP-9 and its cell surface receptors CD11b and CD44 which enhances migration across the extracellular matrix., O-glycosylated and hemopexin domains down-regulate the bioavailability of active MMP-9 and the interactions with the cargo receptors are proposed to be the original function of hemopexin domains in MMPs, Matrix metalloproteinases (MMPs) may have a role in the pathogenesis of endometrioma., the association between the functional polymorphism of matrix metalloproteinases (MMPs) and the development of chronic obstructive pulmonary disease (COPD), MMP9 -8202A/G polymorphism plays a role in the pathogenesis of thoracic aortic aneurysms and thoracic aortic dissections in a white population., Higher levels of MMP-9 in human brain tissue after ischemic and hemorrhagic stroke, suggesting a contribution of MMP-9 to ischemic brain injury and perihematoma edema., The association between pro-MMP-9 activity in plasma and both blood Pb and plasma Pb concentrations suggests a mechanism through which low lead exposure may increase the susceptibility to cardiovascular and neoplastic diseases., Basal secretion levels of active matrix metalloproteinase-9 respond to various extracellular matrix proteins, cytokines, and growth factors in normal human melanocyte cells and melanoma cell lines from different stages of neoplastic progression., two inhibitors of p38 MAPK and protein tyrosine kinase pathways could be used as combined targets for inhibiting MMP-9 expression in inflamed tissues, Up-regulation of MMP-9 expression was observed in atypical and anaplastic meningiomas., sublethal dose of radiation could enhance hepatocellular carcinoma cell invasiveness by MMP-9 expression through the PI3K/Akt/NF-kappaB signal transduction pathway, MMP-9 was also present at the rim of the lesions of secondary progressive multiple sclerosis., results suggest that both MMP-9 and TIMP-1 contribute to tissue remodeling in asthma, Decrease in serum levels eight days after IVIG treatment in neuromuscular disease., In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated., an increased ratio of MMP-9 to TIMP-1 might be associated with the formation of microcysts and peritumoral edema in microcystic meningioma, MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors., These results indicate a temporal relationship between MMP-9 production by endothelial cells and the onset of angiogenic event., We suggest that the increase of MMP-9 levels and activity may be used as a new marker to diagnose the development of heart failure in patients with post MI, and provide the therapeutic implications in the future., plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism, MMP-9 is physiologically regulated by alpha4beta1 integrin and CXCL12 and plays a key role in cell invasion and transendothelial migration in b-cell chronic lymphocytic leukemia., Significantly higher mRNA expression of MMP-9 was found in brain-seeking 231-breast cancer clones in comparison to bone-seeking and parental cells., metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 may have roles in development of systemic lupus erythomatosus, These findings make plausible the involvement of MMP-9/TIMP-1 imbalance in the invasiveness of the endometrial tissue of patients with endometriosis and the ectopic development of the disease., Endothelial progenitor cell (EPC) colony levels are significantly lower in individuals with low HDL, and HDL increases eNOS and decreases pro-MMP-9 in EPCs., Invasion of human cord blood mast cells through Matrigel is mediated by MMP-9 and not by C5a receptor upregulation., Results demonstrated higher expression of MMP-9 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences., gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation, Potential relevance of all-trans retinoic acid as a pharmacological tool to attenuate matrix metalloproteinase-9 secretion in pathological situations., adenosine inhibits MMP-9 secretion by neutrophils; this effect involves the A2a receptor and is mediated through the cAMP/PKA/Ca(2+) pathway, Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis., Genetic polymorphism in MMP9 may have a pathogenic effect in human pulmonary emphysema., roles for eicosanoids in monocyte migration induced by urokinase plasminogen activator and MMP9., promoter gene polymorphism seems to be associated with severe generalized chronic periodontitis, Elevated plasma MMP-9 levels correlated with lower left ventricular(LV) ejection fraction and higher end-systolic volume. Increasing MMP-9 levels are associated with aconcurrent deterioration of LV function., Monocytes can express MMP-9 in response to stromal factors and that this response may be significantly decreased in myelodysplastic-syndrome-derived monocytes., These results demonstrate that NOS2-derived nitric oxide contributes to airway epithelial repair by both PKG-dependent and -independent mechanisms, and involves NO-dependent expression and activation of MMP-9., The results of this study suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1-mediated gene expression through the Akt-dependent ERK and JNK signaling pathways., MMP-9 is strongly expressed in medial smooth muscle cells of atherosclerotic Circle of Willis arteries as well as in atherosclerotic aneurysms., These data demonstrate that the S100A4 gene controls the invasive potential of human CaP cells through regulation of MMP-9 and that this association may contribute to metastasis of CaP cells., TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis., Human labor is associated with increased expression of matrix metallopeptidase 9 (MMP-9) in the myometrium, MMP9 production in small-cell lung cancer cells is suppressed by CD9 and increased by its absence., High matrix metalloproteinase 9 is associated with high-grade gliomas, MMP9 sequence variation was significantly associated with variation in leukoaraiosis volume in both African-Americans and Whites., Data show that MMP9 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family., Elevated levels of MMP-9 iin carotid stenosis were associated with a 2-fold risk of ipsilateral stroke or cardiovascular death. MMP-9 may play an important role in the destabilization of atherosclerotic carotid plaques., We observed a moderatedly increased risk for breast cancer in the TT homozygotes of the MMP9-1562 C/T SNP (OR 1.88, 95% CI 0.97-3.63), Pulmonary fibrosis may be associated with increased TIMP-1 and decreased MMP-9/TIMP1., Lycopene decreases the invasive ability of hepatoma cells by inhibiting MMP-9 expression and suppressing the binding actiity of nf-kappab., results suggest that wogonin effectively suppresses TNF-alpha-induced HASMC migration through the selective inhibition of MMP-9., Astrocytes surrounding amyloid plaques show enhanced expression of MMP-9 in aged amyloid precursor protein (APP)/presenilin 1 transgenic mice., MMP9 was abundant in ovary, but its levels did not change significiantly during the ovulatory process, though levels in the early ovulatory phase were non-significantly higher., polymorphisms are not associated with the susceptibility to chronic periodontitis in the Czech population; however, the promoter variant may influence the severity of the disease in men, Our findings suggest a role for MMP-9 in soft tissue sarcoma (STS) progression and expand the role of p53 in molecular control of STS growth and metastasis., We conclude that ischemic colitis induces increased activity and expression of MMP-9 and MMP-2 in the involved colonic mucosa., The effect of chitooligosaccharides (COS) on activity and expression of MMP-9 in HT1080 cells is reported., High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases., SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute primary angle closure glaucoma., These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure., The relation of nocturnal melatonin levels to serum MMP9 concentrations was studied in patients with myocardial infarction., MMP-9 in stroma may play a key role in the invasion of calcifying odontogenic cyst., in cultured human vascular smooth muscle cells (VSMC), aggregated LDL (agLDL) -internalization down-regulates MMP-9 activity ina a time -and dose- dependent manner, The MMP9-1562T allele is associated with a reduced risk of preeclampsia., A definitiion of part of the catalytic domain of gelatinase B/MMP-9, but not the zinc-binding or fibronectin domains, as target for the development of selective inhibitors., DPC4 regulates MMP9 and may inhibit the proliferation of colon cancer cell by restraining growth and inducing apoptosis, elevated MMP-9 is strongly associated with the increased incidence of in-hospital mortality and cardiogenic shock observed in type 2 diabetes, matrix metalloproteinase 9 (MMP-9)levels are increased in complicated atherosclerotic plaques and in plasma level of patients with carotid atherosclerosis, MMP9 -1562 C/T polymorphism in this particular study do not provide evidence for a major role for this gene in nonsyndromic cleft lip and palate., Our findings demonstrated that the shear stress-induced MMP-9 expression involved integrins-p38 MAPK or ERK1/2-NF-kappaB signaling pathways., MMP9 polymorphism is associated with prostate cancer development and aggressiveness, MMP-9 glycoforms secreted by tumor cells are unlikely to be tethered at the site of secretion, thus promoting more extensive cleavage of the extracellular matrix and providing a rationale for the contribution that MMP-9 makes to cancer cell metastasis., Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line., increases invasion in human pituitary adenoma cell line, Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis., These results suggest that silibinin represents a potential anti-metastatic agent suppressing PMA-induced cancer cell invasion through the specific inhibition of AP-1-dependent MMP-9 gene expression., In co-cultures endothelin-1 produced by endothelial cells results in neutrophil activation/degranulation and proMMp-9 release., NF-kappaB is a key mediator of the invasive phenotypic changes induced by RRM2 overexpression., We therefore found no evidence that MMP-9 is a marker of susceptibility for AAA., targeting constitutive expression of AP-2alpha in AP-2-positive KM12C colon cancer cells with small interfering RNA resulted in an increase in their invasive potential, downregulation of E-cadherin and increased expression of MMP-9, The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells., Parotid saliva of Infantile chronic recurrent parotitis patients showed an increased protein concentration, altered mode of protein diffusion, a higher frequency of polypeptide bands ., Infliximab treatment decreases MMP-9 in serum of patients with CD, the latter also in the intestine, which extends and confirms our previous ex vivo explants observations., No significant differences in the genetic distribution and allelic frequency of -1562C/T MMP-9 SNP between myocardial infarction patients and centenarians., Manganese and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to fibrinogen., Loss of GST and gain of MMP-9 in Barrett with dysplasia compared to non-dysplastic metaplasia indicate that these alterations may be early events in carcinogenesis, MMP9 may have a possible role in the determination of arterial function; has potential implications for involvement in the pathophysiology of cardiovascular diseases., Purified MMP9 was able to cleave the soluble, monomeric forms of native collagen types I and III at 37C and 25C, respectively., Upregulation of matrix metalloproteinase-9 (MMP-9) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees., Siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma., the transcription factor NF-kappaB, p42/p44 MAPK, p38 MAPK, and JNK are involved in MMP-9 expression in tracheal smooth muscle cells exposed to IL-1beta, This study demonstrated that proteinase expression, particularly of MMP-9, is modulated by pemphigus vulgaris (PV) serum and associated with PV acantholysis., Plasma levels are increaed diabetic patients which may reflect abnormal extracellular matrix metabolism., MMP and TIMP plasma levels in premature coronary artery disease are linked to clinical presentation and markers of inflammation and metabolic disorders rather than to genetic polymorphisms, MMP9 induction promotes E-cadherin posttranslational modification involved in metastatic dissemination., "protein kinase Calpha-NF- kappaB"-dependent cascade is involved in the signaling leading to phorbol myristate acetate-induced MMP-9 expression in the lung epithelium, This study does not provide strong evidence for further investigation into the role of the MMP-9 SNPs in melanoma progression, mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics, eIF4E and MMP-9 expression was significantly higher in supraglottic and hypopharyngeal carcinoma than distant margin and normal mucosa tissue., MMP9 levels were significantly higher in diabetic patients with the acute coronary disease syndrome than in nondiabetics., We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite., Cystic fibrosis samples possessed increased levels of active MMP-9, as well as decreased amounts of tissue inhibitor of metalloprotease-1 (TIMP-1), a natural inhibitor of MMP-9., expression of FLNa regulates constitutive activation of the Ras/ERK pathway partly through a Ras-GRF1 mechanism to modulate the production of MMP-9., The aim of the study was to determine the pattern of immunohistochemical expression of transforming growth factor beta1 (TGFbeta1), metalloproteinase 9 (MMP-9), and Ki-67 in colorectal cancer and adenomatous polyps., role FAK plays in promoting cell invasion through the activation of distinct signaling pathways induced by EGF with protein MMP-9 transcription and secretion in follicular thyroid carcinoma cells, matrix metalloproteinase-9 may have a role in fibrinolysis in human blood, distinct deficits in NO production and elevations in MMP-8 and -9 expression in diabetic human skin fibroblasts compared to normal, Expression of active MMP-9 was increased in 9L/F344 rat brain during the growth of malignant gliomas at different time intervals, which indicate that 9L/F344 animal model may be a prospective animal model to test new MMPs inhibitors., gene polymorphisms for MMP-9 did not show any association with the G-AgP in Chinese subjects with generalized aggressive periodontitis, apoptotic keratinocytes impair the extracellular domain of cell surface desmoglein 3 by MMP-9 activity, Combining staging by endoscopic ultrasonography and MMP-9 improves the accuracy in deciding the invasion and metastasis in the patients with gastric carcinoma., These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14., The secreted MCP-1 may affect the production of MMP-9 in fibroblasts and/or macrophages., AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP9., Il-6 and matrix metalloproteinase-9 provide a link between inflammation, matrix degradation and the development/progresion of acute coronary syndrome., CD147 enhanced the activity of MMP9 secreted by systemic lupus erythematosus mononuclear leukocytes., a novel 82 kDa species of proMMP-9 was purified from the plasma membrane of THP-1 leukaemic cells, which has substantial differences from the secreted 94 kDa proMMP-9, Activated MMP-2 and MMP-9 were detected in eight out of nine cases of floppy valves., Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways., Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response., MMP_9 polymorphism of the T allele has an increased risk for developing oral cancer only in initial stages,not in advanced stages.This may be due to the role of MMP-9 in the inhibition of angiogenesis by generating angiostatin from plasminogen., MMP-9 polymorphisms may not be independent factors to influence susceptibility to adult astrocytoma, MMP-9 in plasma is asscociated with radical production during carotid endarterectomy., C-reactive protein induces matrix metalloproteinase-9 production in human mononuclear cells, proMMP-2 and proMMP-9 secretion are decreased in THP-1 cells infected with Toxoplasma gondii, Bcl-2 induces the expression of MMP9 in rernal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro., no significant differences were observed in distribution of the MMP-2-790T/G, -955A/C, and MMP-9-1562 C/T polymorphisms or haplotype of MMP-2 SNPs between patients and controls, Hypoxia induces epidermal keratinocyte MMP9 secretion via the protein kinase C pathway., hypoxia-induced keratinocyte migration is mediated by increased cellular secretion of MMP-9 via the PKC pathway, describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes, KiSS-1 and MMP-9 are closely related to the formation of portal vein tumor thrombus. KiSS-1 gene might suppress the formation of PVTT by suppressing MMP-9 synthesis., Expression of MMP9 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue., incidental clear cell renal cell carcinomas strongly expressing MMP-9 and TIMP-2 have a higher nulclear grade(worse prognosis)., The activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3., An imbalance between MMP-9 and TIMP-1 in induced sputum in asthmatics and COPD is associated with airway inflammation and airflow limitation., showed reduction in MMP-9 levels in the abdominal aortic aneurysm wall in patients randomised to simvastatin., These data reveal a new mechanism by which host- and pathogen-derived factors act together in Mycobacterium infection to drive MAPK-dependent MMP-9 secretion from respiratory epithelial cells., Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension., Study found that an HIV-1-dependent increase in matrix metalloproteinase 9 production from donor cells significantly contributed to the cell-to-cell transmission of the viral products., In macrophages, raloxifene significantly reduced MMP-9 secretion in a concentration-dependent manner, without affecting MMP-9 activation., release of active MMP-9 by IL-13-stimulated KCs may play a crucial role in skin inflammation by facilitating migration of leukocytes into the epidermis., These novel structural details should facilitate the design of more selective MMP-9 inhibitors, During acute phases after stroke, resveratrol preconditioning suppresses matrix metalloprotease-9 activity to ameliorate blood-brain barrier disruption, edema formation and neuronal cell death., MMP-9 was present in 59% of cancer patients and the lytic activity was enhanced in pleurisy and absent in cirrhosis., Functional MMP-9 -1562 C>T polymorphism is associated with oral squamous cell carcinoma risk only in younger areca chewers., COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness., increased in stromal spindle cells and vascular wall of vocal fold polyps compared with normal vocal folds, MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow., Cholesterol inhibits MMP9 expression in epidermal keratinocytes and HaCaT cells., Arsenic trioxide may down-regulate the expression of VEGF and inhibit the activity of MMP-2 and 9., The significant decrease in T allele carriership (p = 0.01), was found in female MS patients in Serbia., simultaneous downregulation of urokinase plasminogen activator receptor and MMP-9 using RNAi technology may provide an effective tool for breast cancer therapy, TIMP-1 and its inhibitory domain, N-TIMP-1, are weak inhibitors of MMP9., multivariate analysis confirmed that enhanced MMP-9 expression was an independent and significant factor for prediction of a poor prognosis in colorectal cancer., VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women, The -1562C>T polymorphism in the MMP-9 promoter is strongly associated with acute myocardial infarction., P-gp substrate drugs can greatly upregulate the expression of CD147 and MMP2 and 9 in multidrug resistant breast cancer cells, therefore enhancing the tumor metastatic capability., Matrix metalloproteinase-9 is increased in plaques causing coronary artery syndrome., MMPs also cleave a variety of non-ECM proteins, including cytokines, chemokines, and growth factors, activating or inactivating them, or generating other products that have biological consequences., NGAL in complex with activated MMP-9 is present in AAA wall and thrombus., Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of CD147., MMP-9-1562C>T polymorphism affects lymph node metastasis of colorectal cancer in northeast Chinese population., Elevated MMP-9 levels in H. pylori-infected gastric mucosa are reversible by eradication of the infection., results indicate that Abeta peptide increases MMP-9 secretion through integrins; MMP-9 then directly processes cell surface APP695 with an alpha-secretase like activity, substantially reducing the levels of secreted Abeta peptide, Multinucleated giant cells (MGCs) in tuberculous lymph-node biopsy samples express high MMP-9 levels adjacent to areas of necrosis, and may contribute to inflammatory tissue damage in human tuberculosis., MMP-9 may be considered a potential biomarker to determine and predict the invasive nature of pituitary tumors., Increased mmp-9 is assopciated with squamous cell laryngeal carcinoma, Nicorandil suppresses the increases in MMP2 and MMP9 levels and activities and prevents the development of ventricular remodeling in acute myocardial infarct, EBV may play an important role in the development of mucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly., Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants., S. enterica serovar Typhimurium activates proMMP-9 (gelatinase B) secreted by human primary macrophages, Correlation between MMP-2 expression levels and the collagen fraction in the pathological hearts indicated a putative role of MMP-2 in the fibrosis that takes place in congestive heart failure., MMP-9 is involved in B-cell chronic lymphocytic leukemia nodal infiltration, The CC homozygote genotype of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene had increased matrix metalloproteinase 9 (MMP-9) levels compared with T allele carriers., Elevated serum matrix metalloproteinase 9 concentration is associated with colorectal neoplasia, Increased expression of matrix metalloproteinase 9 is associated with pulmonary sclerosing hemangioma, MMP-9 expression increased by SDF-1alpha enhances lung cancer invasiveness through the CXCR4/ERK/NF-kappaB signal transduction pathway, Studied four angiogenic gene SNPs (VEGF-1154G/A;VEGF-634G/C;MMP9-1562C/T and TSP1-8831A/G)in combination to the risk of prostate cancer. Results suggest the gene-gene polymorphisms' interaction increased risk of prostate cancer onset & aggressiveness., role of the HPV gene E2 and transcription factor NF-kappaB in the induction of MMP-9 expression in squamous cell carcinoma of human uterine cervix., SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level., imbalance of serum MMP-9 and tissue inhibitors of metalloproteinases 1 levels in patients with acute encephalopathy following prolonged febrile seizures may be associated with severe neurological sequelae, the structural model of full-length pro-MMP-9 and, in particular, the molecular character of its unique proline-rich and heavily O-glycosylated (OG) domain., serum MMP-9 levels are strongly associated with vasculo-Behcet's disease, particularly aneurysmatic involvement, suggesting their pathogenetic roles in vasculo-Behcet's disease complicated with aneurysm formation, Mmp9 gelatinase activity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice., Chymase-induced MMP-9 activation may play an important role in the progression of abdominal aortic aneurysm, Low molecular weight heparin treatment of abdominal aortic aneurysms was associated with decreased plasma MMP-9 activity., The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma, MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2, One single irradiation of UVB increases the immunohistochemical expression of gelatinases in almost all evaluated cell lines, with the exception of MMP-9 in keratinocytes, These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal., Patients with low- and high-grade CIN were found to have significantly different plasma MMP-9 levels but not MMP-2 levels., Acrolein increased pro-hMMP9 cleavage and activity in concentrations (100-300 nM) found in sputum from chronic obstructive pulmonary disease COPD subjects., MMP9 is activated by acrolein, a component of cigarette smoke, and leads to mucus production, No difference exists in gene expression of MMPs in ascending aorta and AV between patients with BAV and TAV., Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in idiopathic dilated cardiomyopathy patients, was significantly different from that in healthy controls., a major role for host-derived MMP-9 in angiogenesis and in the growth of human pancreatic cancer in the pancreas of nude mice., polymorphisms in MMP1, MMP2, MMP3, MMP9, or MMP10 weren't associated with acute MI compared with angina or with coronary disease. Circulating levels of MMP9 are independently associated with development of an acute MI rather than stable angina., MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression., MMP2, MMP14, and MMP9 might be used as prognostic markers in patients with sinonasal and oral malignant melanoma., results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion, Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes, serum level significantly and positively correlated with carotid-femoral pulse wave velocity in hypertensive patients, MMP-9 (type IV collagenase) was also found in synovial fluid from patients with rheumatoid arthritis., 1562 gene T allele might be associated with a decreased risk for generalized aggressive periodontitis in the Turkish population., Col-IV regulates the secretion of MMP-9 via a Src and FAK dependent pathway in MCF-7 cells, Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9., In early human stroke we found evidence of increased oxidative stress and a relationship with MMP-9 expression., Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable coronary artery disease., COX-2 and MMP-9 have synergistic effects on proliferation, invasion and metastasis of cancer cells., The aim of this study was to analyse the influence of recombinant IFN beta-1a (identical with natural IFN-beta) on MMP-2 and MMP-9 activities, Therefore, the strong inhibition of MMP-9 expression by irisolidone might be a potential therapeutic modality for controlling the growth and invasiveness of gliomas., role of C(-1562)T promoter polymorphism in myocardial ischemia, the findings of this study provide mechanistic reasons for the unique proangiogenic function of neutrophil-derived MMP-9., MMP-9 abnormal expression may play a role in the increased vessel density notoriously found in bone marrow of acute myeloid leukemia (AML) patients at diagnosis and thus it may be involved in the leukemogenic process and in myelodysplastic syndrome., Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis., No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF., results suggest the usefulness of MMP-9 as a tumor marker in diagnosis, but not in prognosis of esophageal cancer, data suggest that MMP-2 -735C/T, MMP-9 -1562C/T and MMP-12 357Asn/Ser polymorphisms are not associated with susceptibility to severe CP in Turkish population. T allele of MMP-9 -1562 gene might be associated with decreased susceptibility to severe CP., Investigation of cellular responses to experimental phonation may provide insight into how matrix metalloproteinases and other extracellular matrices contribute to maintenance of the vocal fold and development of pathology., High concentrations of MMP-9 found in patients with carotid stenosis and cerebral lesions suggest that MMP-9 assay could be useful in the evaluation of all carotid lesions to help identify those at highest risk of a neurologic event., down-regulation of matrix metalloproteinase (MMP)-9 protein levels in prostate cancer., our results demonstrate associations of MMP-9 genotypes with different stages of carotid atherosclerosis., Proinflammatory effects of VIP are associated with stimulation of exocytosis of secretory vesicles as well as tertiary (gelatinase) granules with up-regulation of MMP9., MPO and pro-MMP-9 activity may contribute to the development of fat meal induced endothelial damage., MMP-9 was not associated with the clinical course of melanoma., The K23 motifs of RECK protein can inhibit MMP-9 secretion and activity and attenuate metastasis of lung cancer cells., IR/visible light spectrum of sunlight significantly increased skin MMP-9 expression., Data show that increased expression of MMP9 was associated significantly with low histological differentiation of the tumor, deeper tumor invasion, and was more often observed in tumors of colorectal cancer patients with unfavorable prognosis., Enzyme immunoassays showed the levels of metalloproteinase 9 were virtually the same in colorectal cancer and mucosa., The results herein provide initial evidence that the inhibitory effect of hypoxia on MMP-9 by mature dendritic cells requires the activation of A(2b) in a cAMP/PKA-dependent pathway., MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B, Taken together, we demonstrate that EPA inhibits TNF-alpha-induced MMP-9 expression through inhibition of p38 and Akt activation., These data suggest that MMP-9 and MMP-14 overexpression may have an important role in gllbladder tumorigenesis., These data show that Snail functions as a molecular mediator of TGF-beta1-regulated MMP-9 expression by increasing Ets-1 and thereby contributing to oral cancer progression., results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs., The cleavage catalyzed by beta-hematin coincides with the first cleavage by matrix metalloproteinase-3, and preincubation of matrix metalloproteinase-9 with beta-hematin enhances the activation rate by matrix metalloproteinase-3 at least 6-fold., The matrix metalloproteinase 9 C-1562T polymorphism significantly influenced matrix metalloproteinase 9 mRNA expression in alveolar macrophages., found significantly higher immunohistochemical MMP9 levels in decidual cells and adjacent interstitial trophoblasts in placental sections of preeclamptic versus gestational age-matched control women, MMP-2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer., Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling., HCG increases the secretion of MMP-2 and -9 in cytotrophoblasts in a dose-dependent manner., The dysregulated MMP9 expression is associated with infertility and early pregnancy loss., Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis., These results may suggest that the expression of matrix metalloproteinase-9 (MMP-9) and cathepsin B is correlated with lymph node metastasis in advanced gastric carcinoma, but not with patients' postoperative survival., MMP-9, but not MMP-2, may have a role in mechanisms for stimulation of cell division and matrix biosynthesis, which cause matrix remodeling in the umbilical cord of preeclamptic newborns, ESE-1 negatively regulates the invasion of oral squamous cell carcinoma via transcriptional suppression of MMP-9., TGF-beta1-induced HaCaT cell migration is mediated by MMP-14, which regulates MMP-9 expression via JNK signaling, The expressions of MMP-9, IL-8 and LMP-1 were significantly associated with neck lymph nodes metastasis in nasopharyngeal carcinoma., Microvessel and inflammatory MMP-9 response are associated with hemorrhagic complications after stroke, B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44., Resveratrol can inhibit the proliferation of SMMC-7721 cells and down-regulate MMP-9 expression., results suggest that in A549 cells, phosphorylation of p42/p44 MAPK, JNK, and transactivation of NF-kappaB are essential for TNF-alpha-induced MMP-9 gene expression, Specific knockdown of MMP-9 revealed a close correlation between invasion-dependent events and liver tumor cell-derived MMP-9 expression., MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke, coordination of ERK signaling and NF-kappaB and Brg-1 activation are indispensable to regulation of Axl-dependent MMP-9 gene transcription, study demonstrates a significantly higher expression of MMP-9 in adenoma with high grade dysplasia-colorectal cancer sequence as compared to normal tissue; over-expression of MMP-9 strongly suggests its association with colorectal carcinogenesis, uPA-mediated direct activation of MMP-9 may promote glioblastoma cell invasion., Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), MIF, and matrix metalloproteinase-9 (MMP-9), decreased significantly after weight loss., the role of MAP kinase signaling pathways in Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells., pro-matrix metalloproteinase-9/proteoglycan heteromer interacts with gelatin and collagen, NGAL and MMP-9/NGAL complex suppression might have a protective role in women with PCOS., Megakaryocytic progenitors expressed matrix metalloproteinase-9 (MMP-9) and membrane-type (MT) 1-MMP, and transmigrated across the reconstituted basement membrane Matrigel., Overexpression of Gelatinase B is associated with advanced rectal carcinoma, Stromal expression of MMP-9 (matrix metalloproteinase-9) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps, These data suggest that neutrophils are good candidates to be the main source of MMP-9 following t-PA stroke treatment and in consequence, partially responsible for thrombolysis-related brain bleedings., The absolute concentration of TIMP-1 in the airway, rather than its molar ratio with MMP-9, was associated with persistent wheezing., Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE (subacute sclerosing panence)., The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in TRAIL-induced expression of uPA, IL-8, MMP-7 and MMP-9., Alpha-1-antichymotrypsin is a pathophysiologic inhibitor that controls MMP-9 activation in skin tissue., results establish a central role for MMP-9 in the pathogenesis of COPD by demonstrating that expression of this protease in macrophages can alter the extracellular matrix and induce progressive air space enlargement in mice., members of the Hh pathway, especially Gli1, play an important role in the invasiveness of pancreatic cancer cells through the regulation of MMP-9 expression., c-FLIPL promotes the motility of HeLa cells by activating FAK and ERK, and increasing MMP-9 expression., Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features., in colorectal neoplasms, MMP-2 expression correlates with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlate with venous invasion, Unlike MMP-1 and MMP-9 genotypes, MMP-3 5A allele, with higher transcriptional activity, may be a risk factor for the poor prognosis of hepatocellular carcinoma, Zymography, Western blotting, and immunofluorometric analysis of diabetic nephropathy urine showed a significant association especially between activation of MMP-9 as well as PMN-type MMP-8 and TRY-2, MMP9 expression was upregulated in gastric mucosa and positively associated with lymph node metastasis, Surgical wound-produced host Pro-MMP-9 and tumor cell VEGF might be important mediators leading to metastasis of residual breast cancer after surgery., These results suggest an important role for MMP-2 and MMP-9 in the induction of T. cruzi-induced acute myocarditis., Overexpression of MMP-9 results in increased generation of antiangiogenic fragments, decreased angiogenesis, and therapeutic effects of established breast cancer., study has shown significant associations between the two nonsynonymous MMP-9 polymorphisms with lymph node metastasis in gastric cancer, especially with the diffuse type, NO is incapable of directly activating proMMP-9 and S-nitrosylation of MMP-9 propeptide by NO-donors is unrelated to their ability to regulate MMP-9 activity, regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH., These results describe a novel mechanism for the potentiation of TGF-beta1 signaling to induce MMP-9 expression via Smad and MLCK., Berberine induced down-regulation of MMP9 in gastric neoplastic cells in vitro., Atorvastatin does not alter interferon Beta-induced changes of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in patients with multiple sclerosis, MMP-9 plays a role in the pathophysiology of gestational hypertension., Various drugs with a triptan-like chemical structure interact with cellular components of the innate immune system, resulting in an apparent indirect inhibition of NKC activity and direct inhibition of neutrophils pMMP-9 secretion., Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer., Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs, suppression of expression of matrix metalloproteinase-9 in breast cancer cells, MMP-2 stimulates keratinocyte survival whereas MMP-9 promotes terminal differentiation., MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not., the G allele of MMP-9(matrix metalloproteinase 9) polymorphism rs2250889 is overrepresented in patients with histologically confirmed giant cell arteritis, MMP-9 is a poor clinical biomarker of remodeling and outcome in patients with systolic heart failure, arsenic in the airway can alter the airway epithelial barrier by restricting proper wound repair in part through the upregulation of MMP-9 by lung epithelial cells., Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor, This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG (primary angle-closure glaucoma) in this sample of Chinese subjects., Neither MMP-2 SNPs nor MMP-9 SNPs revealed significant association with proliferative diabetic retinopathy in single-locus comparisons., A possible involvement of MMP-9 inmandibuloacral dysplasia type A disease., Haplotypes in the MMP-9 gene may correlate with the progression of endometriosis., Overexpression of MMP-9 is associated with ovarian carcinoma, MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of astrocytoma., genetic polymorphisms of the MMP-9 promoter regions are not associated with the development of systemic lupus erythematosus in Korea, The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry., identification of a series of proteins whose levels are affected by MMP-9, some of which are clearly direct substrates for MMP-9 and become candidates for involvement in metastasis, The expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in a verrucous proliferative leukoplakia sample, was investigated., ) expression of MMP9 increased after surgical manipulation of vein grafts in all patients, Expression of gelatinases or their inhibitors did not have any significant correlations with prognosis, although MMP-9 predicted a good response to first-line chemotherapy., KLF5 causes cartilage matrix degradation through transcriptional induction of MMP9, providing the first evidence that transcriptional regulation of a proteinase contributes to endochondral ossification and skeletal development., The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients., the increased expression of MMP9 gene caused by genetic polymorphism in the gene promoter is important in the early development of serious complications of chronic obstructive pulmonary disease, study demonstrates different patterns of association between inflammatory markers and MMPs in men and women, strengthening the hypothesis of gender specific differences in pathophysiological mechanisms of myocardial infarct, MMP9 release representing ongoing aortic degradation after endografting can be inhibited by doxycycline therapy to increase aortic stability and improve the results of endografting., estrogen receptor 1, vitamin C receptors SLC23A1 and SLC23A2, and matrix metalloproteinase MMP3 and MMP9 are associated with susceptibility to lymphoma, PKC inhibitors blocked phagocytosis by retinal pigment epithelial (RPE)cells. Human RPE-cell line showed reduced secretion of MMP-2, although MMP-9 secretion by PKC activation was conserved in both cell types., In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9., While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055), Data suggest that RECK protein is inversely correlated with tissue damage and MMP-9 secretion in systemic lupus erythematosus., Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages., Plasma levels of MMP-2 and MMP-9 are increased in obese patients which may reflect abnormal extracellular matrix metabolism., human coronary smooth muscle cells and dimethyl sulfoxide-differentiated HL60 cells upregulate ProMMP9 activity and promote mobility-modulation by reactive oxygen species, MMP9 transcription activity is significantly upregulated along with neuron and glial cell apoptosis following spinal cord injury in transgenic mice., MMP-9 gene P574R polymorphism is associated with esophageal squamous cell carcinoma., Curcumin can suppress Tca8113 invasion and migration by reducing the activities of MMP-2 and MMP-9., There was a significant correlation between over-expression of ICAM-1 and TIMP-land MMP-9 in lung tissues from patients with chronic obstructive pulmonary disease., In patients with high-risk bacteria, MMP-8-, MMP-9- and TIMP-1-concentrations were higher than in patients with low-risk bacteria., MMP-9 and TIMP-1 might play an important role in the development of systemic sclerosis., MMP-9, DJ-1 and A1BG proteins are overexpressed in pancreatic juice from pancreatic ductal adenocarcinoma, Upregulation of MMP-9 with NF-kappaB activation may be involved in the tumour invasion of cholangiocarcinoma., Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear, the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9., MMP7 and MMP9-mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses, MMP-9 in cortical plaques in multiple sclerosis patient is associated with loss of perineuronal nets, The role of matrix metallopeptidase 9 in the invasiveness of stomach cancers is reported., In human OSE cells, stimulation of MMP9 gene expression and proteolytic activity by IL-1alpha is suppressed by anti-inflammatory cortisol through a glucocorticoid receptor-mediated mechanism., the genetic tendency to higher levels of circulating MMP-9 was not associated with AAA., TNF-alpha-induced MMP-9 expressions are involved with migrations of smooth muscle cells, The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues., These studies demonstrate a new level of transcriptional regulation of MMP-9 expression by the cooperative action of co-activators., no significant association between the MMP9 polymorphic alleles or genotype and memory was detected in 449 Han Chinese participants, Magnolol inhibited MMP-9 expression through the transcription factor NF-kappaB in TNF-alpha-induced 5637 cells., The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells., These results suggest that TGase 2 inhibits MMP-9 via downregulation of MMP-9 transcription activity by blocking the binding of the Jun-fos complex to an AP-1 site., the simultaneous downregulation of uPAR and MMP-9 induces apoptosome-mediated apoptosis through FADD-associated protein RIP and caspase 9, MMP-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines, expression of constitutively active STAT3 significantly reduced the inhibitory effect of Polyphenon E on cell migration and VEGF and MMP9 expression, high basal MMP-9 activity is associated with tumoral syndrome in childhood acute lymphoblastic leukemia, Plasma MMP-9 levels were higher (p<0.05) in allergic nasal polyp patients than in non-allergic nasal polyp patients and controls. In the group with ANP, plasma MMP-9 levels showed a positive correlation with eosinophil counts., results suggest that the MMP-9-1562C/C genotype is associated with the intrapulmonary spread of pulmonary tuberculosis rather than its development., A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found., Measurements of MMP-9 in wound fluid may help to identify ulcers at risk of poor healing in diabetic foot ulcers., Vanillin inhibits MMP9 expression through down-regulation of NF-kappaB signaling pathway in human hepatocellular carcinoma cells., Treatment with BDNF for 24 h significantly enhanced the level of MMP-9 secreted by myeloma cells in a dose-dependent manner., Our preliminary study suggests that serum MMP-9 levels on birth day are important for predicting neurological prognosis of neonates with asphyxia., the equilibrium between MMP-9 and TIMP-1 is important in lymphomas in addition to all the physiological and pathologic events although MMP-9 and the TIMP-1 staining patterns are not related to the tumor stage, prognosis, and type of the disease, Significantly higher matrix metallopeptidase 9 expression is associated with prostate cancer., The interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children., Level of plasma MMP-9 and MMP-9, MMP-9-PEX inhibits angiogenic features of endothelial cells and retards intracranial glioblastoma growth, HCMV infection specifically alters the MMP-9/TIMP-1 balance in human macrophages, which in turn reduces MMP-9 activity in infected cells., Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression., A diagnostic tool incorporating the values of matrix metalloproteinase 9, brain natriuretic factor, d-dimer, and S-100beta into a composite score was sensitive for acute cerebral ischemia., In this review, the complex regulation of MMP9 within the uterus is highlighted, and the potential novel role of microRNAs in the regulation of this protease is discussed., ADAM10 and MMP9 to be involved in RAGE shedding., SLPI inhibited the expression of MMP-9 and IL-8 in normal human bronchial epithelial cells induced by cigarette smoke extract., MMP9 is downregulated in lobular carcinoma in situ compated with normal breast epithelium and stroma., The structural changes in the venous wall in addition to the increased expression of MMP-2, MMP-9 and MMP-13 in venous aneurysms suggests a possible causal role for these MMPs in their pathogenesis., Non-surgical periodontal treatment was effective in reducing the levels of MMP9 in gingival crevicular fluid from diabetic patients with chronic periodontitis., matrix metalloproteinase-9 is induced in keratinocytes by histamine, Increased level of MMP-3, MMP-9, and IL-6 may be responsible for ectasia formation in patients with coronary artery ectasia., a significant increase in osteopontin and MMP-9 levels and activity in patients with prostate cancer, Cervicovaginal MMP-9 correlated with cervical ripening before labor at term., glioma cells enhance EPC angiogenesis via VEGFR-2, not VEGFR-1, mediated by the MMP-9, Akt and ERK signal pathways, Serous and mucinous ovarian tumors express different profiles of MMP-9., that p38 MAPK and Akt signaling pathways are crucial for the ErbB2-induced MMP-9 up-regulation, invasion and migration of MCF10A cells, The MMP9 Arg668Gln polymorphism was significantly associated with a decreased risk of skin SCC., MMP-9 gene silence by lentivirus mediated RNA interference can inhibit invasion and growth of laryngeal squamous cell carcinoma., MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis can be markers of acute rejection after liver transplantation., Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis, On the basis of linked-function analysis, we demonstrated that collagen binding domain of MMP2 tuned the cleavage of collagen IV by MMP9, presumably by inducing a ligand-linked structural change on the type IV collagen., Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells., Results suggest that nitric oxide attenuates 12-O-tetradecanoylphorbol 13-acetate-triggered matrix metalloproteinase-9 mainly through a direct inhibition of protein kinase Cdelta., Matrix metallopeptidase 9 Arg279Gln and Arg668Gln polymorphisms are associated with non-small cell lung cancer., The elevated expression of MMP-9 and TIMP-1 may influence the behavior of ghost cell odontogenic carcinoma., MMP-9 levels are independent predictors of Crohn disease and ulcerative colitis, The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis., This is the first study comparing the expression of metalloproteinase-9 in cancer and inflamatory infiltrate cells in different histopatological types of esophageal cancer., MMP-9 could up-regulate collagen deposition, possibly through TGF-beta activation, the involvement of Notch1 in human PCa invasion and that silencing of Notch1 inhibits invasion of human PCa cells by inhibiting the expression of MMP9 and uPA, Associations between MMP-9 and galectins-1 and -7 in situ indicate presence in hypopharyngeal and laryngeal squamous cell carcinomas., MCT-1 in combination with aacytidine significantly induced MMP-9 in leukemic HL-60 cells., MMP9 and malondialdehyde may have a common role in the pathophysiology of acute coronary syndrome, FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9., Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways., MMP-9 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls., Results describe the levels of matrix metalloproteinases 2 and 9 in human scar tissue., Data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway., MMP9 expression in human malignant glioma cells was up regulated by mutant IkappaBalpha., The results show an association of MMP1-1607GG alele and the lack of association of MMP9 C-1562T variant with bronchiectasis., Overexpression of MMP-9 was found in esophageal squamous cell carcinoma and may play an important role in carcinogenesis., Recruitment of mesoangioblasts requires the secretion of MMP9 by M2 macrophages., Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion., RECK is a glycosylphosphatidylinositol-anchored glycoprotein that inhibits the enzymatic activities of MMP-9, thereby suppressing fibrosarcoma metastasis., TNF-alpha induces the activation of COX-2 by the up-regulation of MMP-9 via PGE2 receptors in cholangiocarcinoma., A molecular mechanism by which the recruitment of a H3K4 histone methyltransferase complex on the promoter of a NF-kappaB-dependent gene induces its expression., As(2)O(3) inhibits expressions of COX-2, MMP-2 and MMP-9 in K562 and SGC7901 cells., In preeclampsia, first trimester increased serum levels of MMP-9 and TNF-R1 suggest the presence of an underlying inflammatory process; MMP-9 is not useful in the prediction of preterm delivery., Results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas., Activated protein C resulted in MMP-13 activation in cartilage cultures, and it was associated with increased MMP-2 and MMP-9 activity., Enhanced expressions of MMP-2 and -9, VEGF, and increased microvessel density in endometrial hyperplasia may play important roles in the pathogenesis of women with anovulatory dysfunctional uterine bleeding., PAR-2 is a possible mediator cooperating with LMP-1 and MMP9 to influence the progression of nasopharyngeal carcinoma by inducing angiogenesis and promoting lymph node metastasis., These data suggest that a component of airway remodeling associated with asthma may be directly regulated by MMP9., The plasma concentration of MMP-9 is inhibited by isoflurane preconditioning in patients undergoing cardiac valve replacement after cardiopulmonary bypass., Results describe the effect of histamine on cell adhesion and expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 in human tumorigenic and non-tumorigenic mammary cell lines., The results suggest that common variations in three of the genes that control breakdown of matrix proteins in the sclera may contribute to the development of simple myopia., These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of coronary artery disease (CAD) and -1562 CT/TT genotypes may contribute to CAD in diabetics and myocardial infarction in CAD patients., We identified a novel mechanism for MMP-9 expression in response to injury signals, which is mediated by PAK1 activation, Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation., Study showed that MMP-9 and TIMP-2 were highly produced in brain microvessels while MMP-10 was notably increased in neurons of the ischemic brain but not in healthy areas., Plasma MMP-9 is not a good biomarker of chronic urticaria, MMPs play an important role in carcinogenesis in biliary cancers, PUFA studied, AA alone influences the expression of MMP-9, Combined hyperlipidemic patients have increased levels of prothrombotic and microinflammatory parameters and higher levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 than control subjects., Results indicate that CCL5/CCR5 axis enhanced migration of oral cancer cells through the increase of MMP-9 production., Statin therapy did not alter serum MMP-9 in patients with abdominal aortic aneurysms., Obese children and adolescents had higher circulating MMP-8 concentrations, lower plasma TIMP-1 concentrations, and higher MMP-8/TIMP-1 ratios than non obese controls., oxidative stress-dependent reduction of a SIRT1 causes elevation of MMP9 expression, the ability of estradiol to affect MMP-9 and TIMP-1 expression is connected with ERalpha status, The JAK3/ERK pathway may play an important role in epidermal growth factor induced MMP-9 expression in SKBR3 cells., Report relationship between serum MMP-9 and TIMP-1 levels and left ventricular measures and cardiovascular risk factors, MMP-9 could play an important role in pathogenesis of secondary brain injury, The results of this study indicate strong time-dependent gelatinase expression primarily from MMP-9, suggesting that the inflammatory response induced by focal lesions should be considered as a new therapeutic target., Lipopolysaccharide-inducin mucin production may be partially mediated by MMP-9 activation., Our study revealed increased immunoexpression of MMP-2, MMP-9 and TIMP-2 in acute cellular rejection of renal allografts, level of MMP-9 is increased in cholesteatomas/can be linked to more aggressive clinical behavior of cholesteatomas/ MMP-9 can be a key molecule of bone destruction during cholesteatoma progression., Matrix metalloproteinase-9 gene polymorphism is not associated with coronary artery disease., R279Q polymorphism of the MMP9 gene was associated with an increased risk of coronary heart disease., the -1562C/T polymorphism of the MMP-9 gene is associated with a high risk of degenerative disc disease in the young adult population in North China., Curcumin has anti-inflammatory properties and may prevent the migration of aortic smooth muscle cells by suppressing MMP-9 expression through down-regulation of NF-kappaB., During the mechanical stimulation period human keratinocyte monolayers strongly increased the release in the medium of matrix metalloproteinase 9 (MMP-9), a proteolytic enzyme necessary for keratinocyte migration., BMP-4 induced by NDRG2 expression inhibits the metastatic potential of breast cancer cells, especially via suppression of MMP-9 activity., this study demonstrated the effect of thrombin in inducing expression of MMP-9 in monocytes., no significant difference in expression of MMP 9 in scar tissue, hepatocellular carcinoma without cirrhosis was characterized by low matrix metalloproteinase-9 expression, Protein expression levels of lipocalin-2 are upregulated in visceral adipose tissue of obese subjects along with increased activity of matrix metalloproteinase-2 and matrix metalloproteinase-9/ lipocalin-2 complex., Increased expression of MMP9 is associated with astrocytoma pathogenesis and progression., OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., curcumin has anti-metastatic potential resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells., High MMP-9 expression is associated with follicular thyroid neoplasms., The polymorphism -1562 C/T of the MMP-9 gene is not associated with the risk of sporadic amyotrophic lateral sclerosis in the studied population of, The expression of MMP-2 and MMP-9 were closely related with destruction of the ossicular chain in cholesteatoma., downregulation of PSA expression suppressed the proliferation, migration, and invasion of PC-3 cells, as well as the secretion and expression of matrix metalloproteinase-9 (MMP-9)., LPS-stimulated secretion and activation of MMP-9, and the regulatory effects of this pathway on the production of MUC5AC in the human airway cells NCI-H292 were studied., Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cells., Our findings indicate a general upregulation of MMP-9 in ALS. MMP-9 seems to play a role in both neurodegeneration and skin changes in ALS and could thus be a common factor linking otherwise distant aspects of disease pathology., In hypertensive patients, increased MMP-9 activity could result in increased degradation of elastin relative to collagen and non-elasticity, Based on a systematic review and meta-analysis, circulating MMP-9 concentrations are higher in patients with abdominal aortic aneurysm., The presence of nuclear beta-catenin and high content of mmp-9 in the tumor were associated with abnormal accumulation of laminin in the cytoplasm. These changes were characteristic of colorectal cancer with high invasive metastatic potential., In lentigo maligna melanomas, MMP9 was associated with architectural disorder and atypia. MMP9 may have a specific role in the invasive phenotype., It is suggested that matrix metalloproteinase-9 is an important marker for analysis of the postoperative prognosis and risk of metastases in the liver in patients with colorectal cancer., Results suggest that the MMP-9 gene may be a common susceptibility gene to major psychoses with different allelic variants occurring in bipolar illness and schizophrenia., sCD40L increases vascular smooth muscle cell proliferation and migration through the MMP-9 pathway, which may be a potential mechanism through which sCD40L induces intimal hyperplasia and atherosclerosis., Data challenge the functional nature of the -1562C/T polymorphism and its capacity to modulate MMP-9 expression levels and saphecous vein smooth cell invasiveness, and hence susceptibility to vascular pathologies in vivo., that MMP9 and CD147 expression are correlated with invasion, metastasis of squamous cell carcinoma of the uterine cervix., Data show that the expression levels MMP1, MMP9, ADAM9 and TIMP3 were altered in drug-resistant sublines., MMP-9 might play an important role in the pathogenesis of acute graft versus host disease, The migration of bone marrow (BM) mesenchymal stromal cells was the result of the variable level of MMP/TIMP in response to inflammatory stimuli., FOXO3a promotes invasive migration by inducing the expression of matrix metalloproteinase 9 (MMP-9) and MMP-13., High matrix metallopeptidase 9 is associated with breast cancer., Data suggest an involvement of matrix metalloproteinases 2 and 9 in pseudoxanthoma elasticum pathology., The results show that adipose tissue per se is not associated with circulating MMP-9., Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis in patients treated with bare metal stents., In atherosclerotic plaques from subjects with type 2 diabetes, the deregulation of MMP9 activity is related to inadequate expression of TIMP3 via SirT1., surface expression of CD44 and activation of MMP9 on the cell surface are interdependent., Plasma Hg concentration is positively associated with both pro-MMP-9/TIMP-1 and pro-MMP-2/TIMP-2., Significantly higher expression of MMP-7 and MMP-9 in tumor tissue than in the surrounding tissue or in benign lung disease tissue supports the notion of an important role of these metalloproteinases in the growth of lung carcinoma, Data show that downregulation of EMMPRIN by p53 leads to a decrease in the activity of MMP-9 and an inhibition of tumor cell invasion., found that OPN could activate MMP9 and upregulate MMP2, In non-alcoholic steatohepatitis livers, MMP9 was mainly immunolocalized on neutrophils, and in HVC-infected livers it was mainly localized over biliary canaliculi, bile ducts and hepatocyte cytoplasm. Blood levels of MMP9 were increased in both diseases., the novel TIMP-free MMP-9/FGF-2/FGFR-2 pathway in proMMP-9-induced angiogenesis in a mammalian setting., There was no difference in MMP-9 and TIMP-1 levels between ictal and interictal periods in migraine, Mutation in MMP9 determines the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia., Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease., Up-regulation of MMP-2 and MMP-9 is one of the mechanisms by which Skp2 promotes lung cancer cell invasion., In patients with pancreatic cancer, the serum levels of MMP-9, TIMP-1, and tumor markers were higher as compared with those in patients with chronic pancreatitis and healthy subjects., The single nucleotide polymorphisms rs2250889 located in MMP-9 might be associated with primary angle closure glaucoma among southern Chinese people., The results suggest that overproduction of MMP-9 and TIMP-2 is associated with accumulation of the pleural effusion in malignancy., Activation of the kinin B1 receptor by a bradykinin receptor antagonist triggers release of MMP9 in neutrophils., The combined measurement of PTEN and MMP9 transcripts might represent a novel reliable tool for the differential diagnosis of high-grade gliomas., MMP9 would be required in the initial steps of invadopodia formation., The deregulation of MMP9, and the TNF participation in the MMP1 and proMMP9 secretions, in the MMP9 expression and in the expression and cleavage of ICAM1 may contribute to the pathophysiology of endometriosis disease., Increased expression and activity of MMP-9 in CRP-induced human THP-1 cells may be associated with activation of NF-kappaB., The -1562C>T polymorphism of MMP-9 gene is significantly associated with atrial fibrillation risk in Chinese Han patients with hypertensive heart disease., The results may provide the first evidence for the involvement of MMP-9 gene in prefrontal cognition in bipolar mood disorder., Decreases in MMP-9 in female multiple sclerosis patients coincided with a decrease in enhancing lesion volume on MRI., Studies indicate that RAGE is subject to ectodomain shedding by ADAM10 and MMP9 and the derived sRAGE can sequester Abeta for systemic clearance and antagonize Abeta binding to cell surface RAGE., MMP-26 and MMP-9 may contribute to the more aggressive behavior of squamous cell carcinomas in organ transplant recipients, TGF-beta1 increases Slug via ERK1/2 signaling, and thereby contributes to oral squamous cell carcinoma progression., increased expression in interstitial pneumonia, 3,3'-Diindolylmethane (B-DIM) down-regulates uPA-uPAR in aggressive breast cancers but in the absence of uPA-uPAR, B-DIM can directly inhibit VEGF and MMP-9 leading to the inhibition of cell growth and migration of breast cancer cells, glioblastoma cells may be attracted by endothelial cells, enhancing their proliferation and underlines the importance of SDF-1, cathepsin B and MMP-9 in the cross-talk between these cells in normoxic conditions, These preliminary data demonstrate the expression of metalloproteinase 2 and 9 proteins in the placentas of uncomplicated pregnancies., Results suggest that MMP-9 might play a role in the progression of CIN., The mRNA expression of MMPs and TIMPs was significantly higher in stroma than in epithelium of salivary gland pleomorphic adenomas., Gene expression profiling revealed a marked decrease in metalloproteinase 9 (MMP-9) and MYL9 expression after MAL inhibition., up-regulation of Notch1 expression also reduced the migration of Hep-2 cells, which was closely associated with down-regulation of MMP-2 and MMP-9., Plasma and serum MMP-9 were significantly higher in GC gastric cancer compared with healthy controls, MMP polymorphisms had no significant impact on the risk of developing chronic obstructive pulmonary disease in this Brazilian sample., Expressions of MMP1, MMP9, TIMP4, and EMMPRIN were significantly unbalanced in the myocardium of congestive heart failure patients with rheumatic heart diseases., matrix metalloproteinase-9 does not have a major role in risk of myocardial infarction and stroke in older men and women, ROC curve and Kaplan-Meier curve analysis showed that a high secretion of MMP-9 (>2450 pg/ml/10(6) cells) was associated with a lower overall survival rate, suggesting that the secretion of MMP-9 is an independent prognostic factor in childhood B-ALL, increased circulating MMP-8 and MMP-9 levels and proteolytic activity in periodontal disease patients that decrease after periodontal therapy, circulating MMP 9 in extremely low birth weight infants was considerably higher than has been reported in healthy adults and older children, Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma., Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B, The cerebrospinal fluid MMP-9/TIMP-1 (Matrix metalloproteinase 9/ tissue inhibitors of metalloproteinase-1) ratio was significantly increased in neuro-Behcets disease group compared to controls., EP3 receptor signaling on endothelial cells is essential for the MMP-9 upregulation that enhances tumor metastasis and angiogenesis., stimulation of COX-2/PGE2 and MMP-9 by reactive oxygen species-activated ERKs is involved in the invasion/migration of U87 glioma cells, expression of MMP-2 and TIMP-1 was found to be higher in lung cancer patients. Finally, we claim that determination of MMP-9 enzyme levels and expression of MMP-2 and -9 and TIMP-1 can be used as a marker in lung cancer., Carriers of G-insertion in MMP-1, PM increased their BCM and lost ECW more than the non-carriers; homozygote for 21 or less CA repeats/allele in MMP-9 PM gained more MES than carriers of longer microsatellites (63 N, IQR=40-86, p=0.028)., Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells, evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR, Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils, cytokines and inhibitors have an up- or down-regulatory effect on MMP-2 and MMP-9 expression in lung cancer and malignant mesothelioma, galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway, LCN2 is a critical factor in enhancing breast tumor formation and progression possibly in part by stabilizing matrix metalloproteinase-9, Results suggest that MMP-9 and TIMP-1 overexpression are early markers of breast carcinogenesis preceding tumor invasion., The host MMP-9 -1562/TIMP-1 372 SNPs had gender differences in the risk of intestinal metaplasia after H. pylori infection., Women with invasive ductal carcinoma exhibited increased blood levels of MMP-9, NGAL and MMP-9/NGAL comlex compared to healthy controls., there is a sevenfold excess of MMP-9 (matrix metallopeptidase 9) in wound fluid as compared to tissue, with 73% in the activated form, de-N-acetyl GM3 activates matrix metalloproteinase-2, but not MMP-9, in melanoma cell lines, In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion., The MMP-9 c.1562C>T gene polymorphism associated with a predisposition to increased plasma MMP-9 levels could constitute a useful predictive marker for diabetic macroangiopathy., reduction in mature nerve growth factor as a consequence of MMP-9-mediated degradation may in part underlie the pathogenesis of cognitive deficits in mild cognitive impairment and alzheimer disease., Quantification of MMP-9 expression seems to provide valuable prognostic information in stage II colorectal cancer, SiO2 may affect the expression of MMP-9 and MMP-9 activity in cultured alveolar macrophages., Phosphoinositide 3-kinase/Akt and NF-kappaB-related pathways contributed to the HMGB1-induced MMP-9 expression and cellular metastatic ability., These results demonstrate an inverse relationship between human MMP-9 and airway hyperresponsiveness and suggest that MMP-9 expression alters leukocyte extravasation by reducing lymphocyte accumulation in the walls of asthmatic airways., patients with systolic heart failure and a high prevalence of coronary artery disease who had elevated levels of metalloproteinases-9 exhibited a significantly worse event free-survival at 45 months than did those without (21% vs. 54%), Statins reduce endothelial cell COX-2 and MMP-9 expression and activity, exerting an anti-angiogenic effect, possibly contributing to the cholesterol-lowering-unrelated protective effects of statins against plaque inflammatory angiogenesis and rupture., analysis of the main cleavage site involved in enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9, ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB, promoter genetic polymorphism associated with susceptibility to nasal polyposis in aspirin-induced asthmatic patients, Higher levels of 87 kDa MMP-9 were found in the gingival crevicular fluid of chronic periodontitis patients compared with controls, and these markers decreased 3 months after periodontal therapy., Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression., MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients., a possible relationship between the entity of morphological disorganization of the oral mucosa in different pathologies and the increase of MMP-2 and MMP-9 expression., The MMP-9 level was significantly higher in patients with ruptured coronary artery plaques., Report uregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D., The increased expression of CD147 and/or MMP-9 correlates with a poor clinical outcome in patients with non-Hodgkin's lymphoma., In rosiglitazone-treated macrophages, PPAR-gamma mRNA expression was significantly lower while NF-kappaB P65, TIMP-1 and MMP-9 expression were significantly higher in acute coronary syndrome group than in controls., The expressions of MMP-2 and MMP-9 were positively correlated with CD147 expression in breast cancer., These results suggest that lipopolysaccharide and the minor and the major fimbriae of P. gingivalis may play distinct roles in induction by DCs of MMP-9, a potent mediator of local tissue destruction and leukocyte trafficking., Treatment of umbilical cord blood mononuclear cells with recombinant human tumor necrosis factor alpha increased the expression of MMP9., Cav1 might regulate MMP2 and MMP9 activity through Erk-activated signal pathway, Matrix metalloproteinase-9 is a significant predictor of hyperintense acute reperfusion injury associated with blood-brain barrier disruption., The local recurrence had significantly higher MMP-9 expression than their corresponding primary tumors., Results show cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation., Secretion of MMP-9 by follicular fluid-derived cells was associated with the presence of leukocytes., MMP-9 may play an important role in the development of mycosis fungoides lesions, and its significantly higher expression in tumor stages may point to a possible role in disease progression., The average MMP-9 and CRP concentrations increased with increasing degrees of relative wall stress in abdominal aortic aneurysms., Kiss-1 suppresses MMP-9 expression by activating the p38 MAP kinase signaling pathway., Data show that S100A4 binds to Smad3 in a Ca2+-dependent manner, potentiates transcriptional activity of Smad3 and the related Smad2, and increases TGF-beta-induced MMP-9 expression., expression level of SPARC statistically correlated with MMP-9 but not with MMP-1 or -2 in ameloblastoma. Results suggest putative association between SPARC and MMPs (especially MMP-9) in ameloblastoma to regulate tumor invasion., we do not find evidence for the involvement of MMPs-9 in chronic obstructive pulmonary disease, Data demonstrate that EMMPRIN expression increases in the human left ventricle after acute myocardial infarction (AMI), and that expression of MMP-2 and MMP-9 are correlated with EMMPRIN expression in AMI., Overexpression of SPARC decreases angiogenesis, which leads to decreased tumour growth. Further, the role of MMP-9 could be attributed to the anti-angiogenic effect of SPARC., Results show that the treatment of THP-1 cells with CRP enhances the expression of MMPs and TIMP-1, 2, and 9 genes significantly, and that this upregulation is attenuated by atorvastatin, These data indicate that circulating MMP-9 is altered throughout the course of disease progression in mice. Further studies in human ALS may validate the suitability of serum MMP-9 activity as a biomarker for early stage disease., Polymorphisms in MMP2 and 9 promoter regions are associated with endometriosis., Olive oil extract prevents the stimulation of MMP-9 expression in a tumor cell line., CD). We tested the hypothesis that the plasma levels of matrix metalloproteinase 9 (MMP-9) are predictive of cognitive dysfunction after for carotid endarterectomy, In a large cohort of European Caucasian systemic sclerosis (SSc) patients, MMP2, MMP9, and MMP14 genes are not involved in the genetic background of SSc., Sputum samples from cystic fibrosis patients had elevated human neutrophil elastase (HNE) levels which correlated with an increased MMP-9/TIMP-1 ratio. Results demonstrate increased MMP-9 activity in stable CF lung disease., In patients with recurrent nasal polyps the expression of MMP-9 was much stronger than in patients with a better prognosis., The increase of MMP-9 expression in vascular endothelial cells induced by the serum from Kawasaki disease patients might take part in the formation of coronary artery lesions., Elevated serum activities of MMP-2 and -9 are associated with dramatically increased restenosis rates after PCI with implantation of drug-eluting stents., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9., matrix metalloproteinase-9 rs17576 genotype AG, and matrix metalloproteinase-9 rs17576 genotype GG were significantly associated with pelvic organ prolapse., This study assessed the impact of exercise on inflammatory markers and MMPs, and TIMPs. No significant changes were found in body mass index, waist/hip ratio, insulin-resistance indices, MMP-2 and TIMP-1 throughout the study in either group., MMP-9 has a role in B cell chronic lymphocytic leukemia (B-CLL) pathogenesis., The study shows a novel mechanism for antiproliferative effects of PKD1, a protein of emerging translational interest in several human cancers, through increased production of MMP-2 and MMP-9 in cancer cells., distribution of -1562C-->T genotypes significantly different in chronic obstructive pulmonary disease, The findings indicate the significance of interstitial inflammatory infiltrate cells in the MMP-9 synthesis and the role of this enzyme in the invasiveness and metastatic potential of gastric cancer., Our results have shown that homozygocity for MMP-9 variants increase the risk to develop non-atopic forms of asthma and wheezing, which may be explained by a functional role of MMP-9 in airway remodeling., The rs2274756-AA and rs3918242-TT genotypes, younger age, current smoking status and increased fasting plasma glucose, and fibrinogen concentrations were independently associated with high serum MMP-9 concentrations in Taiwanese individuals., MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to diabetic nephropathy., The expression rates of MMP-9, VEGF and TGFbeta-1 in poorly-differentiated follicular thyroid carcinoma were higher than those in well-differentiated follicular thyroid carcinoma., Study confirms an altered MMP9 expression in subjects with chronic C hepatitis and such alterations can contribute to development of liver fibrosis., This study suggested that the MMP-9 gene may play a role in the pathogenesis of alcohol dependence., role of osteopontin (OPN) in prostate cancer PC-3 cells; study demonstrated OPN knockdown could downregulate MMP-2 and MMP-9; IKK-2 may play a crucial role in OPN-induced MMP-2 and MMP-9 expressions via NF-kappaB-mediated signaling pathways, regulates the expression of MMP-2 and MMP-9, which increases the invasion ability of MCF-7 cells through the Ras/MAPK signaling pathway., PTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma., The C(-1562)T polymorphism in matrix metalloproteinase-9 gene is associated with gestational hypertension, but not with preeclampsia., Plasma levels of MMP-9 and its inhibitor TIMP-1 are increased in chronic urticaria patients. MMP-9 levels are associated with disease severity and CRP levels., AGE/RAGE-related MMP-9 expression and apoptosis were correlated with ACE expression in diabetic plaques and RAS may be involved in AGE-dependent diabetic vascular complications., Findings indicate that Twist1 induces HCC invasion via increased activity in MMPs, specifically in MMP2 and MMP9, leading to poor clinical prognoses., Sputum MMP-9 remained elevated after 6 months of smoking cessation, which may contribute to ongoing lung damage typical of chronic obstructive pulmonary disease, In AAA, neither the C1562T nor C-1562C polymorphisms of MMP-9 showed no significant association., The substrate degradomes of two closely related matrix metalloproteinases, MMP-2 (gelatinase A) and MMP-9 (gelatinase B), in fibroblast secreted proteins, were compared., A reduction in the MMP-9/TIMP-1 ratio is a milieu that favors subepithelial airway remodeling in chronic asthma., TNF-alpha induces MMP-9 expression via the TNFR1/TRAF2/PKCalpha-dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways., MMP9 expression is enhanced in gastric cancer compared to normal mucosa., average value of MMP-9 was significantly higher in patients with breast cancer than controls; value correlates with tumor stage and size; results suggest serum MMP-9 is a potential diagnostic marker for predicting breast cancer occurrence and progression, The results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix., The Q279R, P574R and -1562 C/T polymorphisms are not linked with the aggressiveness in prostate cancer, neither they are linked to the risk of suffering prostate cancer, Active forms of MMP-2 and 9 were only present in patients with severe sepsis, and higher MMP-2 levels in skin blister and serum were associated with more severe organ dysfunctions., Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways., MMP9 -1562 C>T was not associated with cancer risk in the whole group analysis, MMP-9 is a novel susceptibility gene and its promoter polymorphisms can affect the development of visceral involvement in Behcet's disease., Exposure to 4N1 K, a specific CD47-activating peptide upregulated two major neurovascular mediators, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), in brain endothelial cells and astrocytes., Functional polymorphism in the promoter region of the MMP-2 and MMP-9 genes plays a certain role in the development of acute coronary events., emodin, aloe-emodin and rhein inhibit the protein levels and activities of matrix MMP-2 but not gene expression of MMP-2; they do inhibit gene expression of MMP-9 and migration and invasion of human tongue cancer SCC-4 cells, data suggest that NGAL promotes the invasiveness of the cholangiocarcinoma cells by forming complex with MMP-9, stabilizing its activity and rendering the cancer cells to be more invasive, Matrix metalloproteinase (MMP-9 and MMP-2) gene polymorphisms influence allograft survival in renal transplant recipients., Findings show that AEG-1 contributes to glioma progression by enhancing MMP-9 transcription and tumor cell invasiveness, and underscore the importance of AEG-1 in glioma development and progression., MMP-9 expression was higher in stage III-IV NSCLC cases compared to stage I-II tumors and higher in NSCLC cases with metastasis than those without metastasis., Data suggest that MMP-9 is involved in signaling pathway-mediated cell invasion and anchorage-independent growth in U1242 MG glioblastoma cells., MMP-9-1562 C/T gene polymorphisms are not associated with susceptibility to chronic gastritis and duodenal ulcer in children., our study forwards new evidence that there is unopposed net gelatinase activity locally in the bronchoalveolar space in bronchiolitis obliterans syndrome likely to be accounted for by MMP-9 from neutrophils., The role of all-trans retinoic acid as a regulator of MMP-9 and the possible signaling pathways which are involved in this ATRA mediated down regulation of MMP-9, was studied., findings indicate laminin-induced MMP-9 expression and activation possibly via alpha2beta1 integrin-mediated signaling involving FAK, PI-3K, ERK followed by transcriptional upregulation of MMP-9 in cervical cancer cell line, analysis of the expression of MMP-9 in patients with embolic and hemodynamic cerebral ischemia due to symptomatic carotid stenosis, elevated serum levels in obese women, Data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway., The overexpression of MMP-9 in pure tumor epithelial, but nor stromal, cell populations was associated with metastatic progression of colorectal cancer., After dsRNA stimulation expression of MMP-9 mRNA increased significantly in human nasal polyp epithelial cells., Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions., The present article studied the expression of CD147 on neutrophils and its potential role in neutrophil chemotaxis, MMPs production and the invasiveness of fibroblast-like synoviocytes., The application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is demonstrated., These results suggest that a genetic polymorphism of the MMP-9 promoter region may influence the susceptibility to multiple sclerosis in Italy., Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147., Matrix metalloproteinase-2 and -9 contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues., MMP-2 and MMP-9 increased significantly in chronic subdural hematoma as compared with those in subdural effusion., Data show that gene expression rates of MMP-2 and TIMP-1 were higher in ONFH biopsies whereas TIMP-2 and MMP-9 gene expression was not significantly altered., MMP-9 activity is increased in the urine of patients with benign prostate hyperplasia compared to cancer., Apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway., Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression, The aim of the present study was to determine glomerular immunoexpression of MMP-2 and MMP-9 in IgA nephropathy and Schoenlein-Henoch nephritis., There was a significant increase in the expression of MMP-9 (matrix metallopeptidase 9) and TIMP-1(tissue inhibitor of metalloproteinases 1) in patellar tendons of patients with tendinopathy., High level of MMP9 expression is a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma., ECs are a source of MMP-9 in the vascular lesions of Kawasaki disease. MMP-9 is regulated by cytokines IL-1beta, IL-6, TNF-alpha and IFN-gamma., MMP-9 but not MMP-3 polymorphism exerts a modulating influence on aortic stiffness and aortic root dilation in patients after TOF repair., The expression of MMP-9 was positively correlated to lymph node metastasis in nasopharyngeal carcinoma., High mmp9 is associated with sacral chordoma., studies demonstrate for the first time negative regulation of MMP9 expression by PDEF, and that PDEF expression was lost in aggressive prostate cancer and was inversely associated with MMP9 expression in clinical samples of prostate cancer, microsatellite (CA)n MMP-9 genotypes are associated with MMP-9 and MMP-9/TIMP-1 levels in subjects exposed to mercury at low concentrations., better usefulness of serum TIMP-1 than MMP-9 in the diagnosis of CRC, especially in the assessment of Duke's classification of tumor stage, survival of cancer patients, resectability of tumor, and in the differentiation between CA and cancer., opioids have an effect on matrix metalloproteinase-2 and -9 secretion and mRNA levels in MCF-7 breast cancer cell line, The combination of VNN1 and MMP9 may be used as a novel blood biomarker panel for the discrimination of pancreatic cancer-associated diabetes from type 2 diabetes., MMP-9 polymorphisms are a putative risk factor of BC in Indian population, Adiposity and systemic inflammation unrelated to obstructive sleep apnea severity, modulate matrix metalloproteinase 9 levels in Greek children., Overexpression of CD151 up-regulated the expression of MMP9 through the PI3K/Akt/GSK-3beta/Snail pathway and promotes neoangiogenesis and progression of hepatocellular carcinoma., The cerebrospinal fluid uPA and MMP-9 levels of the eosinophilic meningitis associated with angiostrongyliasis patients were significantly higher than those of the controls (p<0.001)., a proportional significance of genetic polymorphisms in MMP-2 and MMP-9 genes in black and whitel subjects, E2 protein from HPV16 activated MMP9 promoter predominantly via the MEK1-ERK1/2-AP-1 signaling pathway., MMPs are critical targets of diallyl disulfide-induced anti-invasiveness in human prostate cancer LNCaP cells., We could not identify any polymorphisms of the human MMP-9 gene that were associated with Temporal Lobe Epilepsy, Temporal Lobe Epilepsy with Hippocampal Sclerosis or Temporal Lobe Epilepsy with childhood Febrile Seizures, Specific genotypes of MMP-1, MMP-3 and MMP-9 with lower transcriptional activity are associated with higher frequencies of arteriovenous fistula failure, which may result from more accumulation of extracellular matrix, leading to AVF stenosis., Susceptibility to acute myocardial infarction might be related to MMP-9 gene expression., Early treatment of multiple sclerosis with IFN-beta1b may stabilize clinical disease by attenuating level of MMP-9., Our study suggests that MMP-9 can increase the tau protein level in the sera of patients during acute ischemic stroke., is possible that upregulation of HIF-1/VEGF is involved in the enhancement of MMP-9 expression under hypoxic conditions, High matrix metallopeptidase 9 is associated with non-small cell lung cancer., Results show that myeloperoxidase, IL-8 and MMP-9 were expressed more significantly in both ulcerative and bullous PG than in vegetative PG as well as in Sweet's syndrome., FN induces MMP-9 in HEp-2 cells mainly by involving integrin receptor alpha5beta1 and involves activation of multiple signaling pathways which independently or in "cross-talk" to each other finally leads to the transactivation of the MMP-9 gene., Compared to those in the stratum of 40 or more weeks of gestation, those with the TTC/TT genotypes of MMP-9 C1562T in the stratum of 37 or less weeks of gestation had a significantly increased risk of premature rupture of membranes in preterm delivery., Findings of significantly elevated serum MMP-9, myeloperoxidase, and neutrophil elastase together with decreased TIMP-1 in smoker periodontitis patients provides support for the smoking associated risk of cardiovascular diseases in periodontitis patients, Increased levels of MMP-2 and MMP-9 are induced by CD147 in laryngeal tumor cells., High MMP-9 expression is associated with recurrence in meningiomas., a-mangostin inhibited MMP-2 and MMP-9 activities stimulated by PMA in a dose-dependent manner, Right atrial up-regulation of MMP-3, MMP-9 and TIMP-1 levels may contribute to the right atrial structural remodeling in myocardial infarction patients., Visfatin enhanced the expression and activity of MMP-2 and MMP-9 in human monocytes via activating NF-kappaB signaling pathway., MMP-2 and MMP-9 in conjunction with VEGF-C, promote lymphangiogenesis and lymph node metastasis of breast cancer., investigation of the association of single-nucleotide polymorphism at MMP-1 16071G/2G, MMP-7 181A/G, and MMP-9 279R/Q genes with colorectal cancer in the southwest Chinese Han population, MMP-9 is differently regulated in patients due to a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis; role of MMP-9 as a possible link between stress and cardiovascular disease., The MMP inhibitor GM6001 and MMP-9 blocking antibodies abolished the invasiveness of NPM-ALK(+) lymphoma cells., Gene expression of IL-8 and MMP-9 is related to the development of non-small cell lung cancer., Genetic polymorphisms in MMP-9 gene may modify the susceptibility of hypertensive patients to LV remodeling., Endothelin-1 is a lymphangiogenic mediator. Endothelin-1 induces MMP-2 and MMP-9 in lymphatic endothelial cells., Common genetic variation among single nucleotide polymorphisms in the Matrix Metallopeptidase 9 gene was not found to be significantly associated with breast cancer susceptibility, TLR4 has a role in regulating the expression of MMP-9 in human aortic smooth muscle cells, PTRF/cavin-1-expressing PC3 cells exhibit decreased migration, and that this effect is mediated by reduced MMP9 production., MPB83 of M.bovis may act as a virulence factor through TLR2 mediated induction of MMP-9., Stent-induced activation of macrophage-1 antigen (Mac-1) on the surface of neutrophils might trigger their MMP-9 release, possibly leading to the mobilization of bone marrow-derived stem cells., No significant differences in either genotype distributions or allelic frequencies of MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R were found between patients with POAG and control subjects., Sirt1, a putative anti-ageing enzyme, reduced MMP-9 transcriptional expression in skin., Data show that the colocalization of C5a, MMP-1, and MMP-9 in coronary plaques., GM6001 can down regulate the MMP-9 expression in HCE1 multicellular spheroids and partially block the invasion of HUVECs., Case Report, Matrix metalloproteinase 9 expression level by any cell type was not associated with prostate cancer disease-free survival., We found no association between the -1562 C/T MMP-9 polymorphism and ischaemic stroke, subarachnoid haemorrhage or spontaneous intracerebral haemorrhage in the studied Polish population, Data indicate that Pex domain blade I and IV mutants showed diminished enhancement of cell migration compared with wild type MMP-9-transfected cells., Levels of MMP-9 were increased equally in angina with normal coronary arteries and stable coronary artery disease, but increased further in acute coronary syndrome., The goal of the present study is to investigate the role of metalloproteinase 9 (MMP-9) in vascular complications which is observed in 10% of Behcet's disease patients, metalloproteinase MMP-2 and MMP-9 -to-E-cadherin ratio has an effect on lymphangiogenesis and lymph node metastasis in prostate cancer, NGAL may be considered a novel stress protein, whereas MMP-7, MMP-9, and TIMP-1 may be regarded as indicators of stress response in the pediatric population on chronic dialysis, MMP-9 and -13 mRNA levels are significantly elevated in patients with chronic pain, indicating their possible synergistic effect in intervertebral disc herniation., Data show that MMP-9 mRNA levels were extremely low in all bladder cancer cell lines., matrix metallopeptidase 9 gene polymorphisms are associated with coronary artery stenosis., RECK expression is low in colorectal cancer, while MMP-9 and VEGF-C expressions are high., Short-term use of statins is not associated in reducing levels of MMP 9 in areas of low and peak wall stress in patients with abdominal aortic aneurysms., MMP-9 and PAI-1 are associated with changes in right ventricular structure and function which could be potentially related to a subclinical increase in pulmonary vascular resistance, Immunocytochemistry also revealed protein expression for MMP-2, 3, 8, 9 and 10 in cultured HUVEC., Up-regulation of MMP-9 along with TNF-alpha and IL-1beta in the early course of Guillain-Barre syndrome appears to be associated with immune-mediated disease progression, whereas down-regulation is implicated in recovery from the disease., multiple PKC isozymes form a signaling cascade that controls podosome formation and dynamics and MMP-9 recruitment, release, and activation in a coordinated fashion, NF-kappaB/p65, MMP-3 and MMP-9 are highly expressed in nasopharyngeal carcinoma cells. Their expression is correlated with lymph nodes metastasis, but are not related to sex, age, pathological classification and clinical stage., High Neoplasm Invasiveness is associated with gastric cancer., role for NGAL/MMP-9 dysregulation in renal dysfunction; moreover, gender-specific differences could support a gender contribution to pathological mechanisms or susceptibility for the development of renal complications in diabetes mellitus, EBV LMP1, laminin, MMP9 and IL-6 have roles in the promotion of invasion and metastasis in NPC, results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma., findings of study suggest a role for MMP-9 in the resorptive activity of different cellular groups in CGCLs and indicate differences in immunoreactivity of proteolytic enzyme may underlie distinct clinical behavior., MMP-9 is involved in the process of cell division in neuroblastoma cells and in primary cultures of macrophages., Thrombolytic therapy activated MMP-9, which increased the risk of hemorrhage after thrombolytic therapy., MMP-9 levels increase during days 1-6 of migraine attacks, peaking on day 3. Therefore, MMP-9 could be used as a biological marker to guide treatment of migraine attacks., artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages., investigation of regulation of MMP9 expression (and TIMP1 expression) in trophoblasts under cell hypoxia as a model of placentation under physiological stress (a model for roles of MMP9/TIMP1 in cellular events leading to preeclampsia), MMP-9 is a possible marker for ongoing brain ischemia--REVIEW, Ehm2 may promote the invasive ability of breast cancer cells via regulation of matrix metalloproteinase 9, Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia, CCR7 induces lymph node metastasis of non-small cell lung cancer via upregulating MMP-9 expression., Expression of matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in papillary thyroid cancer, Gastric cancer mucosae produced a significantly higher level of MMP-9 mRNA compared with healthy ones; positive rates of MMP-9 expression were remarkably elevated in association with specific tumor features., Acteoside suppresses PMA)-enhanced MMP9 expression through the suppression of NF-kappaB activation., Functional polymorphisms in the promoter of the MMP-9(-1562C/T) gene from the Colombian population are not linked neither with significant salivary MMP-9 variations in these individuals nor periodontal clinical status., Data show there was a direct correlation between the degree of DSPP-silencing and suppression of MMP-2, MMP-3 and MMP-9., cholesterol levels in lipid rafts are critical for the migration, invasion, and angiogenesis of breast carcinoma cells and could be a critical regulatory factor in these cancer cell processes mediated by uPAR and MMP-9., Increased MMP 1 and 9 expression, and decreased MMP 3 expression are found in long head biceps degeneration. There is a significant association between the size and location of a rotator cuff tear and MMP expression., The content of matrix metalloproteinases (MMP) -2, -7, and -9 was signifi cantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer., Cytochrome P450 omega-hydroxylase promotes tumor angiogenesis and metastasis by upregulation of VEGF and MMP-9, instead of regulating matrix metalloproteinase 9 (MMP9) expression, RUNX3 expression inhibited MMP9 enzyme activity, and this was consistent with the upregulation of tissue inhibitor of metalloproteinases 1 (TIMP1) by RUNX3., The kinetics of MMP-9 confirm its pivotal role in secondary brain damage after ischemic stroke., a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment., MMP9 is critically involved in the proteolytic shedding of MHC class I chain-related molecule A., Dentinal fluid samples from symptomatic teeth diagnosed with irreversible pulpitis had significantly higher MMP-9 levels than those from clinically healthy counterparts., Release of metalloproteases-2 and -9 is blocked after silencing of the kinin B1 receptor with a siRNA., Data show that siRNA in combination with IR effectively reduced both MMP-9 and uPAR expression, thereby leading to increased radiosensitivity of medulloblastoma cells., The present study suggests that urinary LCN2 is a novel marker of hepatic fibrosis by reflecting urine MMP-9 activity in chronic hepatitis C., Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion, metastasis and poor survival, results suggest that matrix metalloproteinase 9 (MMP-9) secreted by trophoblasts contributes to endothelial apoptosis via extracellular release of soluble Fas Ligand, Raf/MEK/ERK disrupted tissue polarity via MMP9 activity. Induction of Raf or activation of an engineered MMP9 in nonmalignant cells led to loss of tissue polarity, and reinitiated proliferation. Silencing MMP9 expression reduced tumor growth dramatically, The level of MMP-9 was positively associated with that of hs-CRP in stroke patients., We revealed a positive correlation between serum levels of MMP-9 in patients with primary ovarian cancer and the size of the primary tumor, MMP9 was overexpressed in epithelial ovarian carcinoma, but expression was normal in benign ovarian tumors., Data confirm that MMP9 activity is induced by EGF/FN in breast cancer cells by the activation of multiple signaling pathways (FAK, PI3 K, and ERK); integrin receptor alpha5beta1 is required in these processes., plays an important role in invasion and metastasis in squamous cell carcionoma of the tongue, MT-2A promotes breast cancer cell invasion by upregulating MMP-9 via AP-1 and NF-kappaB activation., Matrix metalloproteinase is involved in the mechanism of cell-to-cell HIV-1 endocytosis in dendritic cells., Elevated CRP, but not elevated matrix metalloproteinase-9, associates with increased risk of unstable angina, myocardial infarction and death in patients with stable coronary heart disease., Polymorphisms in the promoter region of MMP-9 and TIMP-2 are associated with varicose veins in the Chinese population., These results strongly suggest the underlying mechanism of CXCR4 promoting Tca8113 migration and invasion by regulating MMP-9 and MMP-13 expression perhaps via activation of the ERK signaling pathway., showed the necessity of matrix metalloproteinase 9 in thymic stromal lymphopoietin-promoted dendritic cell (DC) migration by using DCs derived from matrix metalloproteinase 9-deficient NC/Tnd mice, The increased MMP levels in our MG patients...suggest that MMP2, MMP3 and MMP9 play a role in the development of myastenia gravis, Plasma MMP-9 levels are not a robust or reliable marker for eccentric exercise-induced damage of the elbow flexor musculature, though this may not preclude a role for MMPs in skeletal muscle remodeling in response to injury., In asymptomatic type 2 diabetic patients without cardiovascular complications, serum MMP3 and MMP9 were elevated., The gene encoding MMP-9 was neither constitutively expressed nor induced by phytic acid in Caco-2 cells., MMP-9 mRNA expression in peripheral blood mononuclear cells from NPC patients is increased and associated with the clinical characteristics and overall survival., patients with >/=22 repeats in MMP-9 have larger necrotic core and worse prognosis in unstable angina and non ST elevation myocardial infarction., a significant relationship between IGF-II, MMP9 and ventricular septal defects which might be used as diagnosis and prognosis indicators for this defect, no association between the MMP9 genotype and temporomandibular joint degeneration, ECM-derived Ac-PGP could result in a feed-forward cycle by releasing MMP-9 from activated PMNs through the ligation of CXCR1 and CXCR2 and subsequent activation of the ERK1/2 MAPK, The expression of MMP9 in nasopharyngeal carcinoma was up-regulated., Specific single-nucleotide polymorphism in TIMP2 and MMP2/9 appeared to be associated with tumorigenesis and biological behavior in colorectal cancer., Ursolic acid downregulated the expressions of MMP-2 and MMP-9 in ovarian carcinoma cells., These results demonstrate that the early gene E2 of HPV8 is able to increase the expression of MMP9 by direct activation of the MMP9-promoter., Resistin-stimulated vascular smooth muscle cell migration was associated with increased MMP expression, which was dependent on PKCepsilon activation., MMP-9 (and MMP-1) appears to be increased in uterosacral ligaments and vaginal mucosa from women with pelvic organ prolapse (as compared to tissues from health women)., mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group in human pituitary adenomas., In this community-based cohort of elderly men, serum MMP-9 and TIMP-1 levels were related to mortality risk., These Ph(+) putative CML hemangioblast up-regulated TGF-beta1 and result in activating matrix metalloproteinase-9 to enhance s-KitL and s-ICAM-1 secretion., MMP9 gene polymorphism is associated with collagenous colitis., MMP-9 actively participates in nerve growth factor (NGF)-induced alpha-secretase cleavage of amyloid-beta protein precursor (AbetaPP), contributing to the shift of AbetaPP processing towards the non-amyloidogenic pathway., MMP9 polymorphism is not associated with breast cancer., Des-gamma-carboxyl prothrombin stimulates HCC growth and promotes HCC metastasis by increasing the activity of MMP-2 and MMP-9 through activation of the ERK1/2 MAPK signalling pathway, The anti-invasive effects of piperine may occur through inhibition of PKCalpha and ERK phosphorylation and reduction of NF-kappaB and AP-1 activation, leading to down-regulation of MMP-9 expression., EMMPRIN regulates MMP-9 expression in COPD., Data indicate that high expression levels of SDF-1, VEGF, and MMP-9 are more correlated with lymph node metastatic prostate carcinoma compared with non-lymph-node metastatic cancer., High MMP9 is associated with acute rejection of kidney., Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease., study demonstrates that MMP-9 inactivation results in changes in fiber size and type in adult mouse hindlimb muscles that may depend on indirect mechanisms involving reduced bone growth or nerve changes in response to MMP-9 inactivation, Primary central nervous system lymphoma patients without evidence of radiographic disease had significantly lower levels of serum YKL-40 and MMP-9 than patients with active tumor., these results confirm the role of MMP-9 in tissue remodeling associated with prostate tumor invasion., Overexpression of MMP-2 and MMP-9 are often associated with increased invasive metastatic potential of colorectal adenocarcinoma., Results showed that exposure of human monocyte U937 to Nano-Ni caused dose- and time- dependent increase in MMP-2 and MMP-9 mRNA expression and pro-MMP-2 and pro-MMP-9 activity., Faster healing in case of microscope-assisted gingivectomy may be related to the expression of MMP-9 in the gingival crevicular fluid., The aim of this study was to utilize chip gel electrophoresis for investigation of matrix metalloproteinase 9 (gelatinase B, MMP-9) interactions with collagen.The interaction was observed and the effect of temperature was tested., MMP-9 concentrations were lower in the plasma of patients with inguinal hernia and abdominal aortic aneurysm than controls., active form of MMP9 and its ratio with TIMP differed significantly in acute coronary syndromes, Increased plasma MMP-9 levels generally predicted pulmonary status declines, including worsening transfer factor and lung density as well as greater COPD exacerbations in alpha1-antitrypsin-associated emphysema., plasma MMP-9 activity can be regulated by dietary factors such as sodium intake; level of plasma MMP-9 correlates with carotid artery pathology in hypertension; increased plasma MMP-9 activity might play a role in sodium-induced vascular remodeling, Data indicate that the balance between MMPs and TIMPs in women with PCOS is altered, probably due to androgen excess found in these women., No association is found between MMP-9 polymorphism and quality of response to prophylactic lithium administration in bipolar patients., Plasma NGAL and NGAL/MMP-9 complex may act as diagnostic adjuvant biomarkers for pelvic inflammatory disease, PMN derived MMP-9 acts as a potent, direct and VEGF independent angiogenic factor in the context of PDAC., tumors secrete factors that downregulate expression of Fbln5 in fibroblasts at sites of metastatic colonization, in turn upregulating Mmp9 expression and stimulating metastatic organ colonization., MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of subcortical ischemic vascular disease., The MMP-9 rs3918242 functional polymorphism is not associated with susceptibility to sclerosis with and without ulcers., overexpression of HDAC1, 6 or 8 increased invasion and MMP-9 expression in breast cancer cells, High matrix metallopeptidase 9 is associated with relapse in colorectal cancer., AKAP12 is involved in the regulation of endothelial cell migration through the inhibitory regulation of MMP-9 expression in tumor cells., data demonstrate, for the first time, that DDR1 mediates MMP-2 and -9 secretions and invasion induced by native type IV collagen in MDA-MB-231 breast cancer cells, The -1562C/T polymorphism in the MMP9 gene promoter is associated with the susceptibility to MI in the Uighur population of Xinjiang., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., TNF-alpha and MMP-9 may play an important role in the pathological mechanism of nasal polyps. TNF-alpha may induce the expression of MMP-9 and promote the migration of eosinophilic granulocytes., C/C of genotype MMP-9, the periodontitis patients presented higher frequency of 51% than the control 17%. genotype and serum expression of inflammatory mediators that may be a good bio-marker for diagnosis and prognosis of the periodontitis., overexpression of integrinalphanubeta6 and MMP-9 in Gastric cancer is closely correlated with tumor invasion and metastasis., emodin exerts antiproliferative and antimetastatic activity on pancreatic cancer both in vitro and in vivo, which may be related to down-regulation of NF-kappaB and its regulated molecules such as survivin and MMP-9 proteins, PPAR-delta agonists inhibit TGFalpha-induced MMP9 expression in human keratinocytes. This inhibition involves repression of c-fos binding at the MMP9 promoter., Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways, human antigen R knockdown reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9, Silencing MMP9 with siRNA can inhibit the growth and invasiveness of trophoblasts., expression of IGF-II and MMP-9 mRNA were significantly elevated in hepatocellular carcinoma (HCC) in liver tissues of patients compared with healthy controls, Both MMP-2 and MMP-9 were associated with the leukocyte count in pre hemodialysis group., The aim of this study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed., MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans, Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells, Dehydroechinoside A and holothurin A(1) exert significant antimetastatic activities by inhibiting MMP-9 and VEGF expression., Metastasis formation upon up-regulation of full length-L1CAM correlated with increased invasive potential and elevated Matrix metalloproteinase (MMP)-2 and -9 expression and activity., Matrix metalloproteinase-9 in preoperative serum is independent prognostic markers in patients with colorectal cancer, elevated MMP-9, reduced SP, and normal CGRP levels were characteristic of the blood biomarker profiles of alternating hemiplegia of childhood patients, Serum levels of MMP-9 and free fatty acids in severe obstructive sleep apnea-hypopnea syndrome cases were significantly higher than those in control group., Activation of epidermal growth factor receptor promotes squamous carcinoma cell migration and invasion via inducing epithelial mesenchymal transformation-like phenotype change and matrix metallproteinase-9-mediated degradation of E-cadherin, leukocytes are more prone to release and produce MMP-9 in symptomatic and angiographically verified stable angina pectoris, The carriers of the MMP-9 1562C>T allele have high levels of MMP-9 activity, LDL-C, TC and homocysteine, thus are more likely to develop myocardial infarction and coronary artery disease at young age (less than 55 years)., Serum MMP-9 level is a better marker than serum MMP-2 in predicting the breast cancer development and progression., H-Ras activates MMP9 culminating in the development of diabetic retinopathy that leads to the capillary cell apoptosis in the retinal microvasculature obtained from human donors., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., Thy-1 (-) lung fibroblasts stimulated with TGF-beta1 expressed MMP-9., AZT may suppress the activity and production of MMP9 in HBE16 cells so as to inhibit the airway mucous hypersecretion., phenotypic expression on tumor-associated macrophages correlates with non-small lung cancer invasion and progression, MMP-9 was strongly expressed in squamous cell carcinomas and moderately expressed in actinic cheilitis and control samples. A highly significant association was found between tryptase+ mast cell density and the expression of MMP-9., KLK7 may play an important role in the activation of MMP-9 in tumors that express high levels of both these proteases, this study showed that the C(-1562)T polymorphism of matrix metalloproteinase-9 gene is associated with schizophrenia in China., A trend toward increased serum levels of MMP-9/TIMP-4 was found in patients with successful arteriovenous fistulas., The effects of rosuvastatin in reducing MMP-2 and MMP-9, which might stabilize the atherosclerotic plaques, are dose-dependent., MMP-9 plays a crucial role in the pathogenesis of neuromyelitis optica via blood-brain barrier disruption., There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues., S1P regulates MMP-9 induction and invasiveness through coupling of S1P3 and G(alphaq) in MCF10A cells, thus providing a molecular basis for the crucial role of S1P in promoting breast cell invasion., Genetic variation in Matrix metalloproteinase-9 is associated with primary angle closure glaucoma in an Australian Caucasian population., Here, the authors demonstrate that in vitro infection of human macrophages with Leishmania braziliensis increased the secretion and activation of MMP-9., macrophage expression is upregulated by oxysterols through redox-sensitive signaling pathways, CypA promotes HCC cell metastasis at least partially through up-regulation of MMP3 and MMP9, The ethanolic extract of Gynura procumbens inhibited MMP-1 and MMP-9 expressions induced by UV-B irradiation via inhibition of pro-inflammatory cytokine mediator release and ROS production., SLPI stimulates ovarian cancer invasion, modulated in part by its serine protease inhibitory activity attenuating MMP-9 release., Determined expression of MMP-9 in lymphocytic colitis (LC), collagenous colitis (CC) and ulcerative colitis(UC).Expression of MMP-9 in LC and CC was similar to controls. Up-regulation of MMP-9 correlated with the severity of inflammation in UC., Soluble endoglin may participate in the genesis of preeclampsia by affecting the invasive ability of cytotrophoblasts through regulation of the expression of MMP-2 and MMP-9., Results show that SLPI promotes the metastasis of SNU638 gastric cancer cells by increasing MMP-2 and MMP-9 expression through Elk-1 signaling, indicating its role as a signaling molecule not a protease inhibitor., MMP-2 expression is associated with endothelial cells, histiocytes and reactive astrocytes, whereas MMP-9 expression is restricted to inflammatory cells in stroke., In addition to MMP-9, Plasmodium falciparum haemozoin induced MMP-1 and MMP-3, two enzymes sequentially involved in collagenolysis and proMMP-9 proteolytic activation., Serum MMP-9 showed no utility in determining glioma disease status and was not a clinically relevant prognostic marker of survival., MMP9 and CD34 play a cooperative role in the process of squamous cell carcinoma of external auditory canal and middle ear., The MMP-9 -1562 C>T polymorphism may decrease both the colorectal and lung cancer risk., These findings elucidate how phosphoprotein phosphatases and adrenoceptors may modulate tissue remodelling by affecting fibroblast function., MMP-9 tumor cell high expression was significantly correlated with poorer outcome in stage IA non-small cell lung cancer., basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium, we analyzed the correlation, prognostic value, and association with neo-angiogenesis of NGAL and MMP-9 immunohistochemical expression in a series of stage I colorectal carcinomas, The -1562C>T or R279Q polymorphism of MMP-9 gene and smoking have a synergistic effect and are significantly associated with the risk of MI in Chinese Uighur population, respectively., we conclude that the analysed genetic variants in MMP2 are not major contributors to aneurysmal subarachnoid haemorrhage, Combining minocycline with tPA may prevent the adverse consequences of thrombolytic therapy through suppression of matrix metalloproteinase-9 activity., The serum MMP-9 level may be a significant biomarker which can help differentiate patients with unstable angina with plaques from those with unstable angina but without plaques., Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-kappaB pathways in monocytes/macrophages., Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions., Overexpression of MMP-9 resulted in induction of the EMT in A431-P cells and this could be reversed by treating with luteolin or quercetin., at least part of the protective effect of estrogen occurs by attenuation of Ox-LDL alterations in MMP-9 expression, IL-17A could upregulate MMP2 and MMP9 expression via NF-kappaB signaling activation., The 147C strain of Helicobacter pylori expressing tyrosine-phosphorylated CagA (EPIYA present) induced enhanced MMP-9 secretion by gastric epithelial cells., MMP-9 expression is related to the histologic degenerative score in all age groups with intervertebral disc degeneration., High levels of MMP-7 in tumor cells and high levels of MMP-9 in tumor associated stroma were independent positive prognostic factors in NSCLC patients., The effect of a cell-permeable superoxide dismutase (Tat-SOD) on TNF-alpha-induced MMP-9 expression in human keratinocyte cells (HaCaT)., 1,25-(OH)(2)D(3) has a direct inhibitory effect on passively sensitized human airway smooth muscle cells in vitro, including the inhibition of cell proliferation and the expressions of MMP-9 and ADAM33., Global gene expression analysis indicated upregulation of MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in primary human hepatocytes (PHH) in response to stimulation with adiponectin., Hc, even in patients with mild hyperhomocysteinaemia, is involved in the pathophysiology of ascending aorta aneurysms, through the regulation of MMP-3 and MMP-9 activity., Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids., The expression level of MMP-9 and VEGF in recurred group were significantly higher than primary group, higher concentration and activity in nasal secretions of children exposed to passive smoking, Data show that the urinary messenger RNA (mRNA) levels of alpha-smooth muscle actin (alpha-SMA), fibronectin, and matrix metalloproteinase-9 (MMP-9) were significantly higher in the diabetic nephropathy (DN) group, and mRNA levels increased with DN progression., High levels of MMP9 were detected in laryngeal cancer (LC) that plays a critical role in the development of tolerogenic dendritic cells and LC-specific T regulatory, Adrenomedullin produced in colorectal tumors acts in concert with metalloproteinase-9 in the stroma to contribute to the pathogenesis of colorectal cancer., our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells, overexpression of serum response factor in hepatocellular carcinoma may play an important role in tumor cell migration and invasion through upregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, MMP-9 genotypes and haplotypes affect MMP-9 levels in obese children and adolescents, and suggest that genetic factors may modify relevant pathogenetic mechanisms for development of cardiovascular complications associated with obesity in childhood, these data provide new insights into the mechanisms underlying MMP-9-mediated hTERT expression in glioma proliferation, Data suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS., Data show that higher MMP-8 and active MMP-9 levels at 48 hours of disease onset are associated with a longer duration of mechanical ventilation and fewer ventilator-free days among pediatric patients., Concentration of MMP-9 cerebrospinal fluid levels differentiates the diagnosis of patients with vascular dementia from those with Alzheimer's., Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn., results suggest that the combination of cyclic stretching and hypoxia stimulates MMP-9 and cytokine production in macrophages, which may result in weakening of abdominal aortic aneurysms walls., MMP-3, MMP-8, and MMP-9 levels were significantly different between patients with Hyper-IgE syndrome and control subjects and might contribute to some of the characteristic features of Hyper-IgE syndrome, a novel Neu1 and MMP9 cross-talk in alliance with TLR4 on the cell surface that is essential for ligand activation of TLRs and subsequent cellular signaling., MMP-9, MMP-13 and TIMP-1 expression may serve as a prognostic marker for early tumor invasiveness. Moreover, up-regulation of TIMP-1 in tumor and/or surrounding stromal cells may indicate an increased risk for BCC recurrence., Changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces, study demonstrates the potential utility of urinary MMP-2 and MMP-9 to differentiate between ovarian cancer patients with normal CA125 levels and controls, Meta-analysis, MMP-9 and uPA might be involved in the activation of pro-MMP-13 through unknown mechanisms in arthritic diseases., PARP-1 suppressed MMP9 expression in undifferentiated, non-apoptotic keratinocytes., The consistent and increased intensity of MMP9 expression in Hodgkin/Reed-Sternberg cells make this enzyme a potential target for therapy, The higher expression of TGF-beta1 can protect articular cartilage by down-regulating the expression of MMP-9 of chondrocytes and synoviocytes in osteoarthritis., Report activity of MMP2/9 and TIMP-1 in electromagnetic field-exposed THP-1 cells., Matrix metalloproteinase-9 was involved in the immuno-modulatory defect of mesenchymal stem cell from chronic myeloid leukemia patients., Prevention of activation of MMP-9 prevents retinal endothelial cells from undergoing apoptosis by protecting mitochondrial ultrastructure/function and preventing mtDNA damage., Genetic variants in matrix metalloproteinase-9 gene modify metalloproteinase-9 levels in Brazilian black subjects., subarachnoid hemorrhage is associated with elevated CSF MMP9., Enhanced expression and activation of MMP-9 was found in septic native knee arthritis compared with aseptic. The presence of high levels of MMP-9 with concomitantly increased MMP-9/TIMP-1 ratio may be indicative for infection., This is the first study to show that endogenous nitric oxide formation correlates negatively with the circulating levels of both MMP-2 and MMP-9 in black subjects, These data testify to the important role of metalloproteinases 2 and 9 in extracellular interaction and proliferation activity in thymus aging., Data show that SNPs in the MMP-2 and -9 promoter region may be associated with susceptibility to and neck squamous cell carcinoma not in oral submucous fibrosis., The TT homozygotes of MMP9 T-1702A genotype may be predisposed to sarcoidosis., investigated the influence of matrix metalloproteinase (MMP)-9 genetic variations on gene- and protein expression in stable coronary artery disease patients; the investigated MMP-9 polymorphisms influenced gene- and protein expression differently and the R279Q polymorphism associated significantly with hypertension, MMP-9 levels were elevated earlier than hs-TnT and had a higher diagnostic value for early ACS, but not for late ACS, reflecting plaque rupture or vulnerability., Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells., Elevated serum CL, Hpa, and MMP-9 levels are correlated with malignant invasion and progression in ovarian cancer., urine MMP9 seemingly cannot distinguish renal scar from vesicoureteral reflux (VUR), the simultaneous increase in the level of MMP-9 AND TIMP-1 may indicate ongoing renal injury due to vesicoureteral reflux., findings establish that Shh signaling promotes the metastasis of gastric cancer through activation of the PI3K/Akt pathway, which leads to mesenchymal transition and MMP-9 activation, MMP9 may not be a predisposition gene of AIS in Han female., Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9., Tamoxifen decreased the transcriptional expression of MMP-9 in SPC-A-1 lung adenocarcinoma cells., Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis., Pre-treatment of HaCaT cells with Saponins from Platycodon grandiflorum roots inhibited UVA-induced production of MMP-1 and MMP-9., sLZIP plays a critical role in MMP-9 expression and is probably involved in invasion and metastasis of cervical cancer, the pro-matrix metallopeptidase 9/TIMP-1 ratio measured with ELISA is not a good surrogate measure for active matrix metallopeptidase 9, Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort., Increased MMP-9 expression is related to poor prognostic clinicopathological factors in invasive ductal carcinoma of the breast, and hence, it can be utilized as a supplementary prognostic marker., EGF enhanced MMP-9 expression through the activation of p38MAPK and ERK signalling pathways in JEG-3 cells in a time and dose-dependant manner., Whereas serum levels of MMP-9 are associated with the occurrence of childhood asthma, the MMP-9 -1562C/T gene polymorphism has no correlation with the pathogenesis of childhood asthma., Three isolates, consisting of 2 Nonthaburi and 1 heterogeneous isolate, were found to stimulate high TNF-alpha and MMP-9 production during the early infection period., Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule., UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen., Zoledronic acid can inhibit the in vitro proliferation and invasion of HNE1 cell through suppressing the secretion of VEGF and suppressing MMP2 and MMP9 activity., the expression of KLF5 and MMP-9 may be involved in cartilage degeneration, contributing to human osteoarthritis, association among plasma matrix metalloproteinase-9 (MMP-9) concentration, single nucleotide polymorphisms (SNPs) of MMP-9 gene and community-acquired pneumonia, MMP-9 mRNA expression above a certain cut-off level is associated with dismal survival., The allele and genotype frequencies of MMP9 rs17576 and rs2250889 were not associated with the development of gastric cancer development and lymph node metastasis., platelets and megakaryocytes might participate in a positive feedback loop occurring between sCD40L and MMP-9 which would contribute to the proinflammatory state observed in Behcet disease, Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis, SNP -1562C/T in the promoter region of MMP9 does not appear to have a role in recurrent early pregnancy loss, MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation., Protein expression of VEGF, EGFR and MMP-9 is elevated in non-small cell lung carcinomas, correlating with progression., hMR expressed by vaginal epithelial cells has high affinity for HIV gp120 and this binding induces production of matrix metalloproteinases., MMP-9 may be the chemokine ligand 2 (CCL2)-responsive mediator that causes degradation of extracellular matrix leading to subsequent cancer cell migration and metastasis., Results show that MMP-9 is overexpressed and its negative regulators are underexpressed in prostate cancer, emphasizing a possible role of MMP-9 in the carcinogenesis process., mmp-9 snp was associated with higher scores of the personality trait inhibition of aggression in the female population and with higher scores of verbal aggression and irritability in men., These results, besides showing for the first time the nuclear localization of MMP-9 on a large series of human stroke and aged brain tissues, raise new questions regarding the unknown spectrum of the functions MMPs, Inhibition of MMP-9 significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 in facilitating LSF function., RECK and MMP9 are involved in middle ear squamous cell carcinoma and may serve as markers to evaluate progression and metastasis., Results show SMYD3 as an important new regulator of MMP-9 transcription, and provide a molecular link between SMYD3 overexpression and metastatic cancer progression., Study found that Tat protein disrupts occludin by both inhibiting its expression and cleaving it via matrix metalloproteinase (MMP)-9 in brain endothelial cells; this finding may help us understand how HIV-1 factors act during neuroAIDS., BLCA-4 may not effect pro-angiogenic pathways in bladder cancer, it can however interact with IL-1alpha, IL-8, VEGF and MMP-9 to enhance tumourigenesis and tumour invasiveness., an increase in the immunodistribution of MMP-2 and -9 and TIMP-1 and -2 in lichen sclerous compared to normal vulvar skin was observed., Data suggest that MMP9 mRNA level in buffy coat samples of acute stroke patients is 3 times higher in non-survival compared to survival patients; MMP9 mRNA level is associated with severity; high MMP9 mRNA level predicts poor outcome/mortality., ADAM17 contributes to androgen-independent prostate cancer cell invasion by shedding of EGFR ligand TGF-alpha, which subsequently activates the EGFR-MEK-ERK signaling pathway, leading finally to overexpression of MMP-2 and MMP-9., Failed to demonstrate any prognostic relevance of MMP9 levels in advanced epithelial ovarian neoplasms., Increased MMP-9 was associated with permanent atrial fibrillation, whereas increased MMP-2 was associated with paroxysmal atrial fibrillation., ETS1 promotes paclitaxel resistance and invasion in part by up-regulating MDR1 and MMP9 expression., No difference between groups was found in the genotype distribution polymorphisms for COL1A1, MMP-9 and -3, while the distribution of the polymorphism of MMP-1 was significantly increased in the cases when compared with controls., The expression of ERK5 regulates the invasion of osteosarcoma cells by inducing MMP-9 expression., Data suggest that salivary duct carcinoma (SDC) patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression., Statistically significant correlation was found for the expression of MMP9 between primary and recurrent breast carcinomas in general., Methotrexate chemotherapy transiently alters bone marrow cellularity and composition and the reduced cellularity may be associated with increased MMP-9 expression., AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9., Report MMP9 expression in chordomas in regards to prognosis., Advanced glycation end products may play an important role in the impairment of diabetic wound healing by upregulating MMP-9 expression in keratinocytes via the RAGE, ERK1/2 and p38 MAPK pathways, and activation of NF-kappaB., Insignificant association doesn't exclude the possible contribution of MMP-9 to pathogenesis of schizophrenia, Cell-to-cell interaction between endothelial cells and monocytes promotes proMMP-9 synthesis and secretion. Hypoxia and inflammation are suggested to play an important role in activating proMMP-9, presumably via Hsp90., Data show that Tissue factor (TF) down-regulation diminished matrix metalloproteinases MMP-2 and MMP-9 expression and promoted reversion to suspension growth., MMP9 gene confers susceptibility to cedar pollinosis in Japanese children. The MMP9 gene may be associated with pollinosis through sensitization processes., Elevated serum MMP-3 and MMP-9, but not MMP-7, correlated with distant metastasis and poor survival of patients with synchronous squamous cell carcinoma of the upper aero-digestive tract., Andrographolide attenuates MMP-9 expression in THP-1 cells, and its main mechanism might involve the NF-kappaB signal pathway., up-regulation of JunB induced by HGF might play an important role in the regulation of cell proliferation and cell invasion through MMP-9 expression., The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined., Propranolol can treat proliferative hemangioma through decreasing serum VEGF and MMP-9., ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma, Results suggest that EZH2-mediated transcriptional repression of TIMP3 directly leads to activation of MMP-9., Elevation of Hcy content increases permeability of HIMEC layer affecting both paracellular and transcellular transport pathways, and this increased permeability was alleviated by inhibition of MMP-9 activity, Report disturbed interplay between hyaluronan and its binding protein CD44, and an obvious increase and displacement of MMP3/9 in skin of psoriatic arthritis patients., There was no synergy between Streptococcus agalactiae and Escherichia coli for inducing the secretion of inflammatory factors IL-1beta, TNFalpha or degradative metalloproteinase proMMP-9; thus these two bacteria could initiate different pathways to induce chorioamnioitis., This study demonistrated that Expression of MMP-9 was significantly more extensive in mesenchymal than in glial tumor areas., These findings suggest that corticotropin-releasing hormone might induce invasion and migration by upregulating MMP-2 and MMP-9 in endometrial cancer., Protein expression of vascular endothelial growth factor A (VEGF-A) and matrix metalloproteinase 9 (MMP-9) was studied in gastric carcinoma patients in relation to clinicopathological characteristics and prognosis., Results support the use of MMP-9 and TIMP-1 as early biomarkers for the presence and extent of perinatal brain injury in human term newborns., HDAC inhibitor trichostatin A (TSA) increased the expression of TIMP-1 and TIMP-3 while decreased MMP-2, MMP-9 and uPA and have an inhibitory effect on trophoblast invasion., close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues of uterine leiomyomas., C(-1562)T polymorphism may contribute to pathogenetic mechanisms involved in the development of obesity in women, Found a significant positive correlation of intraluminal thrombus thickness with active MMP 9 and TIMP 1 concentration in the adjacent abdominal aortic aneurysm wall., Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis., results are the first to demonstrate that triple-helical peptides are suitable for highly specific in vivo detection of tumor-related MMP-2 and MMP-9 activity, data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis, The role of matrix metalloproteinases (MMPs), hypoxia-inducible factor-1alpha (HIF), and vascular endothelial growth factor (VEGF) in the hypertrophied ligamentum flavum, was investigated., MMP9 is positively expressed in the intracranial meningioma main tumor, but not in the hyperosteosis tissue., Blocking the FAK signaling pathway can reduce the activity of MMP-2 and -9 in corneal epithelium treated with TNF-alpha., Matrix metalloproteinase-9 activity detected in body fluids is the result of two different enzyme forms, expression correlates with severity of chronic rhinosinusitis with nasal polyposis, an anti-angiogenic role for BMP4 in laser-induced CNV, mediated by direct inhibition of MMP-9 and indirect inhibition of VEGF., HMGB-1, a proinflammatory cytokine, is released by ALK(+) cells, and demonstrate extracellular HMGB-1-stimulated secretion of the IL-8 chemokine by HaCaT keratinocytes through the involvement of MMP-9, PAR-2, and the NF-kappaB pathway., analysis of collagen IV and MMP-9 expression in hypertrophic gingiva during orthodontic treatment, This study demonstrated that MMP-9 RNA is upregulated in PBMCs in proportion to ischemia., the present study shows for the first time that MMP-2 and -9 give a main contribution to estrogen's neuroprotective effect., Report increased MMP-9 and reduced TIMP-1 activity in thromboangiitis obliterans patients, especially in active smokers., MMP2 -735 C/T and MMP9 -1562 C/T functional gene polymorphisms might be associated with an increased risk of idiopathic recurrent spontaneous abortion in women., Establishment of cells that overexpressed wild-type and mutant forms of MMP-9 revealed that 'cysteine-switch' and disulfide bonds within the catalytic domain are necessary for the secretion and intracellular trafficking of MMP-9., Chamomile infusion inhibited expression of neutrophil elastase and matrix metalloprotease-9 in adenocarcinoma gastric cells., DSPP, OPN, or MMP-9 expressions at histologically-negative surgical margins predict Oral squamous cell carcinoma recurrence with MMP-9 being the preferred predictor., Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of Behcet Disease, while MMP-9-1562*C/*C may promote the disease., Identification of function for CD44 intracytoplasmic domain (CD44-ICD), significant association between serum MMP9 concentration and the presence of neoplasia; serum MMP9 levels are raised in those with cancer and high-risk adenomas, although MMP9 estimation is likely to have the greatest predictive utility when used as part of a panel of biomarkers, c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D, Report inhibition of MMP-9 production in peripheral blood mononuclear cells by Aloe vera., polymorphism in the promoter region of the MMP9 gene is associated with the risk of the development of lung cancer., our findings suggest that the overexpression and spatial distribution patterns of MMP9 may be linked with the intractable epilepsy caused by focal cortical dysplasia type IIb and tuberous sclerosis complex., Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone., Specific inhibition of MMP-9 by mangiferin in astroglioma cells prevents tumor invasion via PI3K/Akt and MAPK signaling pathways., high MMP-9 expression is associated with a poor prognosis in patients with non-small cell lung cancer, High MMP-9 is associated with colorectal cancer., Elevated levels of CXCR4 and MMP-9 are found in small cell lung cancer tissues., Notch1, MMP-2 and MMP-9 are closely correlated with the progression and prognosis of malignant gliomas. Notch1 may participate in the expression regulation of MMP-2 and MMP-9., Elevated active MMP-9 plasma level is associated with more severe diastolic dysfunction in patients with coronary artery disease and preserved systolic function., Genetic variations in the MMP9 gene are not associated with hemorrhagic transformations occurrence in tissue-type plasminogen activator-treated stroke patients., Serum vascular endothelial growth factor (VEGF)-D is significantly elevated in patients with lymphangioleiomyomatosis and is a better diagnostic marker than matrix metalloproteinase (MMP)-2, MMP-9 and ACE., Fra-1 was induced by Epstein-Barr virus LMP2A and is essential for LMP2A-triggered MMP9 expression., MMP-9 expression in appendiceal tissue was significantly higher in phlegmonous, gangrenous and perforated appendicitis than in noninflamed appendix., the release of pro-inflammatory TNF-alpha, MMP-9, and MMP-2 was higher in cells exposed to oxidized high density lipoproteins (HDL) than those exposed to native HDL, Cells exposed to the Bacillus protein showed a dose-dependent increase in expression of genes coding for matrix metalloprotease (MMP)-3 (61-fold) and MPP-9 (301-fold)., The increased expression of MMP9 plays a crucial role in the development of several human malignancies, including esophageal cancer., MMP-9 expression may not have role in progression from actinic keratosis to in situ and invasive squamous cell carcinoma., We showed that MMP-9 levels of exhaled breath condensate (EBC) are elevated in children with asthma and correlated with lung functions and other inflammatory markers such as IL-4/IL10 in EBC., results demonstrate that the proteolytic enzyme MMP-9 promotes resistant epithelial breast cancer cells migration and tubular network formation through VEGFR-2/ VEGFR-3 activation, analysis of MMP-9 and TIMP-1 after blunt multiple injuries in the early posttraumatic period, MMP-9 was elevated in feces of ulcerative colitis patients, but not in controls or irritable bowel syndrome-diarrhea patients. Fecal MMP-9 levels correlated with overall Mayo score, endoscopic score, and serum C-reactive protein and fecal calprotectin., single polymorphisms in these genes suggest that specific genotype combinations of MMP-9 and VEGF contribute to preeclampsia susceptibility, plasma MMP-9 level substantially increased during the acute period of ischemic cerebrovascular disease and correlated with the severity of the disease and infarct volume., MMP-9 interference affected the tumorigenesis of HT1080 cells in mice as follows (1) inhibition of tumor growth; (2) reduced tumor volume, and (3) prolonged survival time., The influence of transforming growth factor-alpha, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer., MMP-9 levels were related to EDSS score and drug resistance in multiple sclerosis patients, Results indicate that IL-23 promotes the migration and invasion of A549 cells by inducing MMP-9 expression., Melatonin decreased the expression and activity of MMP9 by a NF-kappaB-dependent pathway in HUVECs induced by IL1beta., This study suggests that genetic variants in MMP-2,7,9 and TIMP-2genes are associated with higher susceptibility of gallbladder cancer., the elevated levels of lipocalin-2 and MMP-9 are associated with reduced breast cancer survival, particularly in patients with lower BMI and lymph-node negative breast cancers., these results indicate that ANXA1 functions as a positive regulator of MMP-9 expression and invasion of breast cancer cells through specific activation of the NF-kappaB signaling pathway., H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers, Platelets do not possess the transcriptional activity of a gene encoding MMP-9., META060 inhibited MMP9 expression/activity in TNF-alpha activated monocytes/endothelial cells., The MMP9 R668Q genetic variant was significantly associated with left ventricular dysfunction in coronary artery disease patients., TGF-beta1, MMP-9 and TIMP-1 may play a role in the tissue remodeling process in allergic rhinitis., MMP9 is highly expressed in endometrial cancers and correlates with the progression of the disease., The expression of ET-1 and MMP-9 was associated with clinical stage, T stage and lymph node metastasis in laryngeal carcinoma., Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain, SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell., OPN and MMP-9 may be regulated by TNF-alpha, indicating a possible role in the pathogenesis of psoriasis., NDRG2 could suppress clear cell renal cell carcinoma cell invasion through regulating MMP-9 expression and activity., basal lamina type IV collagen alpha chains, matrix metalloproteinases-2 and -9 expressions are expressed in oral dysplasia and invasive carcinoma, demonstrates that overexpression of MMP-9 is related to unfavorable prognostic factors of urothelial bladder cancer and tumor recurrence, Report induction of VEGF and MMP-9 expression by toll-like receptor 2/4 in human endothelial cells infected with Chlamydia pneumoniae., inflammatory state induced by elective surgery is associated with increased TIMP-1 response and MMP-9 activity in serum within a few days, binding of IL-5 to IL-5Ralpha plays a critical role in MMP-9 expression, which may be involved in the migration of bladder cancer., Individuals carrying the MMP9 -1562T allele are predisposed to stiffer arteries, especially among menopausal women. Women with the T allele should be considered at high risk for cardiovascular disease., MMP-9 P574R and R668Q were not associated with colorectal cancer (CRC) risk, but P574R affected serum cholesterol levels in CRC patients., A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds alpha4beta1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells., Three genes, MMP9, IL1B, and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities., Aromatic-turmerone suppresses 12-O-tetradecanoylphorbol-13-acetate-induced MMP-9 and COX-2 expression in human breast cancer MDA-MB-231 cells., It was concluded that protein kinase C zeta regulated protein kinase phosphorylation, which in turn regulated the proteolytic activity of phorbol dibutyrate-induced podosomes by influencing the recruitment of protein kinase C zeta and MMP9 to podosomes., The present study confirmed that MMP-9 expression in cervical cancer was an independent prognostic factor, Our findings suggest differential expression patterns of MMP-9 and AQP4 in different grades of gliomas, The findings implicate involvement of MMP-9 in the pathophysiology of brain injury following seizures in the developing brain., Our findings suggest that the MMP-9 polymorphism may be associated with intracranial hemorrhage in patients with brain arteriovenous malformation, MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa., The content of MMP-8 an MMP-9 in oral fluid of patients with severe periodontium was slightly higher than that in other patients and subjects with the intact periodontium., It has been observed that increased MMP-9 expression in T allele carriers may contribute to the severity of coronary atherosclerosis, 5-HT4 receptor stimulation induces expression of MMP-9 which cleaves AbetaPP through alpha-secretase-like activity, leading to an increase of sAbetaPPalpha levels and a reduction of Abeta load., This study was to investigate the association between MMP-1-1067, MMP-3-1171, MMP-9-1562, IL-2-330, IL-8-251, COX-2-765 polymorphisms, and the susceptibility to chronic periodontitis in a Chinese population., Using human gastric cancer cell lines, found semaphorin 5A significantly promoted invasive & metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell., The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes, MMP-9 is related with the prognosis of ovarian cancer patients. Functional studies revealed that MMP-9 plays a role in tumor invasion and adhesion., M. pneumoniae in adult community-acquired pneumonia induces activity of MMP-9 in peripheral blood circulation., trend of serum levels of IL-8, IL-6, TGFbeta1, VEGF and MMPs during colorectal carcinogenesis from benign to malignant phases, Cleavage of SP-D by MMP-9 using levels of protein similar to that observed in patients with chronic lung disease suggests in vivo relevance for this cleavage event., Both men and women with Hepatitis C virus (HCV) had significantly elevated levels of circulating Osteoprotegerin (OPG) and male but not female HCV patients had elevated levels of circulating Matrix Metalloprotease-9 (MMP-9)., MMP-2 and MMP-9 downregulation in gallic acid treated K562 cells are mediated through suppression of JNK1-mediated c-Jun/ATF-2 and Akt/ERK-mediated c-Jun/c-Fos pathways, respectively., the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress, Significantly higher mRNA expression of MMP-1, 3, 9 was observed in peripheral blood mononuclear cells of Takayasu's arteritis patients compared with controls., MMP-9 significantly increased HER2/neu expression on the surface of human mammary epithelial cells., The repression of MMP-9 transcription in response to IFNbeta occurs by the recruitment of HDAC1 via the proximal AP-1 binding site., The smallest surface of the trophoblast with positive MMP-9 reaction appeared in the group with untreated Intrauterine growth restriction., LOX, MMP-2, and MMP-9 may have a synergistic role in promoting invasion and metastasis of breast cancer., In pediatric multiple sclerosis, a shift in matrix metalloproteinase-9 balance toward proteolytic activity is evident, MMP-2, MMP-9 and TIMP-2, TIMP-1 may play an important role in the development, progression, invasion and metastasis of non-melanoma skin cancer., A novel role for macrophage-derived MMP-9 in blunting the inflammatory response and limiting extracellular matrix synthesis to improve left ventricular function post-myocardial infarction., Enhanced ovarian neoplasm invasiveness is mediated through nuclear factor kappaB activation and the consequently elevated MMP9 secretion., The MMP9 gene polymorphism may be an important risk factor for the development and progression of chronic obstructive pulmonary disease., In this study, we identify MMP-3 and MMP-9 as potential tau proteinases, Hypertension-induced atherosclerosis was associated with significantly increased levels of MMP-9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation, The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients., Two MMP9 gene single nucleotide polymorphisms were associated with advanced pelvic organ prolapse, Michelia alba extract inhibited UVB-induced MMP-1 and MMP-3 expression and MMP-9 activity., it is likely that active MMP-9 and ADAM10 help regulate the cellular levels of CD44v6 through cleavage of CD44v6 ectodomain during tunicamycin-induced apoptosis of Caki-2 cells., Data suggest that OSM enhances invasion activities of extravillous trophoblasts during placentation through increased enzyme activity of MMP-2 (primarily) and MMP-9 (to some extent)., confirms the importance of MMP-1, 7, 9, and 12 in the development of preeclampsia, findings suggested that MMP-9 protein expression might be a factor for a poor prognosis in patients with gastric cancer, however, the association was rather weak, The combined approach of direct experimental confirmation of the functional alterations of MMP-9 SNPs and logistic-regression analysis revealed significant association between MMP-9 genotype and abdominal aortic aneurysm., TNFA significantly enhanced the TLR3-dependent induction of MMP-9 in human mesangial cells., These results provide a strong rationale for further testing and validation of celastrol as an adjunct with conventional drugs for the treatment of rheumatoid arthritis in humans., CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells., upregulation of MMP-9 contributed by REG 4 protein, synergetic pathways of IL-17A and hypoxia might contribute to the migration and invasion of rheumatoid arthritis synoviocytes by up regulating the expression of MMP2 and MMP9 by activation of the NF-kappaB/HIF-1alpha pathway, High MMP-9 expression in tumor infiltrating CD3 lymphocytes is associated with endometrial cancer., Knockdown of endogenous Bmi-1 reduced the invasiveness and migration of glioma cells. NF-kappaB transcriptional activity and MMP-9 expression and activity were significantly increased in Bmi-1-overexpressing but reduced in Bmi-1-silenced cells., Preliminary evidence suggests that MMP-9 levels are increased in patients developing an endoleak after endovascular aneurysm repair.[review], Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K., Results show that matrix metalloproteinase-9 expression is increased in astrocytic glioma and associated with tumor progression as its expression increased from Grade II to Grade IV glioma., apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma, The imbalanced expressions of MMPs-9 and TIMP-1 in injury repair can be related to poor uterine scar healing and early caesarean scar pregnancy., Exercise duration is of importance in MMP-9 regulation in marathon/half-marathon runners., Elevated MMP-9 levels may play an important role in bone resorption in COPD., end stage kidney disease patients with the QQ genotype for the Q279R polymorphism or with the CLQ haplotype are exposed to more severe increases in MMP-9 levels after hemodialysis, Data show that transfection of ORMDL3 in bronchial epithelial cells induced expression of MMP-9, ADAM-8, CCL-20, IL-8, CXCL-10, CXCL-11, oligoadenylate synthetases (OAS) genes, and selectively activated activating transcription factor 6 (ATF6)., NO. Our data support the hypothesis that reduced NO levels leads to the dysregulation of plaque clearance by decreasing the MMP-9/TIMP-1 ratio, This study showed that MMP-9 increases in sputum samples from sensitized occupational asthma patients after specific inhalation challenge with flour., MMP-9-cleaved betaig-h3 plays a role in MMP-9-mediated tumor cell and macrophage migration, Data indicate that cyclophilin A (CypA) inhibition correlates with the down-regulation of matrix metallopeptidase 9 (MMP9) activity., IVF females successfully conceiving after the IVF have shown the highest MMP-9 concentrations in sera (833.5 {686.0;958.7} ng/mL) and follicular fluids (9.6 {6.0; 17.0} ng/mL) compared to all other examined cohorts., MMP-1, MMP-2 and MMP-9 were significantly more expressed in nasal polyps than in controls., CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis., Simultaneous knockdown of both MMP-9 and uPAR regulated a majority of the molecules associated with glioma cell migration and significantly reduced the migration potential of glioma cells., Azacitidine decreases MMP9 DNA promoter methylation levels, which correlates with a significant increase in mRNA expression in AML cell lines. In MDS patients, azaC increased MMP9 expression & disease progression., The ACE/ACE2 ratio combined with MMP-9 activity in pleural fluid may be potential biomarkers for diagnosing tuberculous pleurisy., PTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing Takayasu arteritis activity., DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women., Piwil2 knockdown also attenuated migration and invasion of colon cancer cells via modulation of MMP9 transcriptional activities., Degradation of ColIV was closely related to increased MMP-2 and MMP-9 expression; MMP-9 have more important function than MMP-2 during the cancer development, Data suggest that MMP2 and MMP9 have dual roles in Trypanosoma cruzi infection of placental chorionic villi; these enzymes may be partially responsible for invasion of extracellular matrix and may be part of local placental antiparasitic mechanism., Results indicate that renal fibrosis is associated with a decline of MMP-9 expression in the cytoplasm of normal tubular cells and increased expression of MMP-9 in the nuclei of tubular atrophic renal tubules., alpha-Tomatine inhibited 12-O-tetradecanoylphorbol-13-acetate-induced expressions of MMP-2 and MMP-9 in MCF-7 cells., These results suggest that MMP-9 transcription may serve as a marker of treatment response to radiotherapy or chemo-radiotherapy in patients with HNSCC, proMMP-9 was identified as a novel substrate. It was shown that aminoterminal meprin-mediated clipping improves the activation kinetics of proMMP- 9 by MMP-3, an efficient activator of proMMP-9., Mere15 inhibits tumor growth via both pro-apoptotic and antimetastasis pathways by reducing MMP2/9 expression., Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection., Heavy smoking noticeably increases native MMP2 and MMP9 gene expression in the SV before CABG., NGAL is a novel target of nuclear factor-kappaB prometastatic activity in thyroid cancer through enhancement of MMP-9 enzymatic activity., Increased plasma levels of MMP-9 predict future coronary revascularization, and a significant association was observed with MMP-9 and low-density lipoprotein-cholesterol., Patients presenting with acute coronary syndromes have increased transcoronary plasma levels of MMP-9 and C-reactive protein., PAR2-AP or FVIIa elicited time-dependent downregulation of caspase-3, and up-regulation of MMP-9 and CD44 in SW620 cells., Gambogic acid reduces the invasive potential of osteosarcoma cells via attenuation of MMP-9 and upregulation of TIMP-1., Findings indicate thet the miR-15a-RECK-matrix metalloproteinase-9 axis in neuroblastoma (NB) progression, especially in NB migration and invasion., We conclude that kep correlates best with serum MMP-9 expression among the pharmacokinetic indices and most closely represents the degree of BBB breakdown., Extracellular MMP-9 is upregulated in the neocortex of patients with intractable epilepsy., Authors found an acute inhibitory effect of miR-211 on glioma cell invasion and migration via suppression of MMP-9., Data suggest that the VEGFR-1/MMP-9 pathway is significantly increased in malignant-rather than in benign-pleural effusions., Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., MMP-9 was related to the development of middle ear cholesteatoma. There was no correlation between LPS and MMP-9., MMP9 polymorphism is associated with endometrial cancer risk., MMP-9 constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP., expression of MMP9 protein was inhibited by knockdown of MACC1 protein expression in hepatocellular carcinoma cells, Dipyridamole exerts anti-inflammatory properties in human monocytes via MMP9 down-regulation., Portal, but not lobular, macrophages express matrix metalloproteinase-9 in chronic hepatitis C patients with liver fibrosis., Data suggest that CD147 overexpression upregulated the protein expression of MMP-9, and strengthened the proliferation and invasive ability of lung adenocarcinoma cells., MMP-9 1562C>T might be involved in the development of periodontitis, There was no significant difference in MMP-9 and MMP-2 expressions between recurrent and nonrecurrent nasal polyps., Our data suggested that the rs1056629A-->C variation contributes to an increased risk of atherosclerotic cerebral infarction by increasing MMP-9 expression through affecting binding of miR-491 to the polymorphic site in the 3'-UTR of MMP-9., Gene array data revealed reduced expression of matrix metalloproteinase 9 with the ablation of either Pak1 or Pak6 gene expression in PC3 cells., The expression levels of CD147 and MMP-9 are positively correlated with invasion, metastasis and shorter survival of triple-negative breast cancer patients, In periapical lesions apoptosis detected and the expression of MMP-9 were higher than in epithelialized gingival lesions., High MMP-9 expression is associated with colorectal cancer., Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear factor (NF-kappaB) activation by inducing the up-regulation of p21(WAF1) protein expression, p53, MMP-2 and MMP-9 can be used for the histological grading of oral Squamous cell carcinoma and its differentiation from Verrucous carcinoma, Docosahexaenoic acid inhibits matrix metalloproteinase-9 expression, mediated by heme oxygenase 1,in 12-O-tetradecanoylphorbol -13-acetate-induced MCF-7 human breast cancer cells., Sulfuretin suppresses 12-O-tetradecanoylphorbol-13-acetate-stimulated cancer cell invasion by inhibiting MMP-9 expression., Patients with basal-like breast cancer have a high expression of CD147 and MMP9, The AngII/ERK pathway has an important role in the production of MMP-9 in nonsyndromic thoracic aortic aneurysm walls., MMP9 may have an important role in early pathological changes in hepatic sinusoidal obstruction syndrome., Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9., Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas., MMP9-1562 C/T polymorphism decreased lung cancer risk in Caucasians., Increased MMP9 mRNA expression levels correlated with axillary-node metastasis in breast cancer., elevated levels of matrix metalloproteinase 9 and matrix metalloproteinase 2/tissue inhibitor of matrix metalloproteinase-2 complex may play a role in spontaneous termination of pregnancy, Down-regulation of Notch2 by siRNA enhanced tumor cell invasion and expression of MMP9, and activated the pro-MMP9 protein to its active form., The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD. [meta-analysis], Lentiviral ADAM17 RNA interference inhibited MMP9 expression, IkappaBalpha phosphorylation and the expression of phosphorylation p65 protein in response to lipopolysaccharides., expression correlates with clinical stage in non-small cell lung cancer, HPV 16 E6 up-regulates pro-angiogenic MMP-2 and MMP-9 through inducing IL-8 expression in lung cancer cells., the effect of the mu-opioid receptor selective peptide, morphiceptin, and its two synthetic analogs on mRNA and protein levels of MMP-9, Taken together, we suggest that silibinin suppresses TPA-induced cell migration and MMP-9 expression through the MEK/ERK-dependent pathway in thyroid and breast cancer cells, Urinary/serum MMP-9 level is associated with the risk of Henoch-Schonlein purpura nephritis. [review], Together with histological grade, increased co-expression of MIF and MMP9 in tumor might be a valuable predictor for recurrence, especially for benign meningiomas, Expression of OPN, CD44v6 and MMP-9 are positively related and involved in the invasion and metastasis of laryngeal squamous cell carcinoma., P. falciparum parasites, either chloroquine-sensitive or -resistant, induce the release of active MMP-9 protein from human microvascular endothelium, by impairing balances between proMMP-9 and its inhibitor, and by enhancing the levels of its activators., The MMP3 5A allele occurred at a higher frequency in patients with acute coronary syndrome (ACS) than in ACS-free individuals in this Chinese Han population., The Matrix Metalloproteinase 9 -1562 C, MMP-9 and MMP-2 are highly expressed by myeloma cells., Report MMP9 activity in chronic pancreatitis and pancreatic adenocarcinoma., High stromal MMP 2 expression were identified as a significant determinant for endometrial cancer recurrence, while epithelial MMP 2 expression and epithelial and stromal MMP 9 expression were not., We confirm altered MMP9 expression in Multiple sclerosis, role in the development of osteitis, Zta drives cell migration and invasion through MMPs, IL-6 expression levels were increased in the plasma of patients with cerebral AVM and this correlated with the activated MMP-9 levels of cerebral arteriovenous malformation tissues., the MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing primary open-angle and angle closure glaucoma in Pakistanis, 6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalos could inhibit invasion and angiogenesis by downregulation of VEGF and MMP-9 in MDA-MB-231 breast cancer cells., Nitric oxide donors downregulate MMP-9 expression in endothelial cells independently of RELA., The data suggest that in human monocytes, nHZ and 15-HETE upregulate MMP-9 expression and secretion through activation of p38 MAPK pathway., MMP9 knockdown increases expression of CD44v6 in PC3 cells., The results of the present study support a model in which the GG and CC genotypes, respectively for IL-6-174 G > C and MMP-9-1562 C > T polymorphisms, are associated with a risk of deep vein thrombosis in cancer patients., P65 is involved in the regulation of MMP9 expression and other key proteins implicated in neoplasm metastasis and invasion., MMP-9 is identified as a potent player in modulating the innate immune response into antitumor activities., Hypomethylating drug 5-azadC and histone deacetylase inhibitor trichostatin A induced modulations in higher order chromatin organization and in MMP-9 and MMP-2 expression in human HT1080 fibrosarcoma cells., Simvastatin and rosuvastatin significantly and dose-dependently reduced RAS protein, MMP-2/9 and NF-kappaB-p65 expression in tumor cells., role of SPARC, MMP-2 and MMP-9 in intracranial aneurysms, The degradation of tight junction proteins such as zonula occludens-1, occludin and F-actin by MMP-9 secreted by amyloid beta-stimulated cells constitutes an important mechanism in the breakdown of the retinal pigment epithelial barrier., Increased levels of MMP9 play a role in the development and progression of acute coronary syndrome., It sicapable of degrading the constituents of the extracellular matrix and the basement membrane and imortant ofr liver regeneration., the authors have identified a new pathway by which overexpression of 12-LOX in prostate cancer cells leads to augmented production of MMP9 via activation of PI3K/Akt/NF-kappaB signaling., important roles of endothelial cells within the prostate cancer microenvironment to promote the prostate cancer metastasis and provide new potential targets of IL-6-->AR-->TGFbeta-->MMP-9 signals to battle the prostate cancer metastasis, the inhibitory effect of TSA on cancer invasion is mediated through the suppression of HDAC2 expression, and the reduction of MMP-2 and MMP-9 expression induced by HDAC2 may be involved in the anti-invasive effect of TSA, Physiological and pathological processes envolving MMP9 are reviewed. [review], Combined analysis of MMP-9 and N-a-acetyltransferase 10 (Naa10) expression has a significantly increased value for the prognosis of breast cancer patients., The findings suggest that elevated levels of MMP-9 are independently associated with increased risk of AF., This meta-analysis suggests, when using healthy smokers as controls, MMP-9 -1562 C/T, but not MMP-1 -1607 G/GG polymorphism is associated with the risk of chronic obstructive pulmonary disease., MMP-9 is increased in women with endometriosis undergoing in vitro fertilization associated with poor oocyte and embryo development., This pilot study first reveals a link between increased levels of circulating gelatinases (MMP2 and MMP9) and polypoidal choroidal vasculopathy but not age-related macular degeneration., Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression., The polymorphisms in the MMP9 gene may be genetic modifiers for breast cancer prognosis in this Chinese population., we found that the MMP9, MMP3 and TIMP3 polymorphisms and MMP3 and MMP12 haplotypes were associated with chronic bronchitis and recurrent pneumonia in Tatar children., GPER promotes the migration and invasion of ovarian cancer cells by increasing the expression and activity of MMP-9., In vitro evidence that MMP9 forms a stable chondroitin sulfate proteoglycan-proMMP9 complex., TLR2 gene expression and MMP-9 levels were significant independent contributors to the proportion of sputum neutrophils in COPD after adjustment for age, prior smoking, and the presence of airflow obstruction., Transfection with HO-1 small interfering RNA knocked down the HO-1 expression and reversed the inhibition of MMP-9 expression by AP., In human studies, plasma levels of MMP-9 were significantly increased in patients with septic shock as compared with healthy controls, although MMP-9 levels did not correlate with organ injury score., the MMP2-1306 C>T polymorphism is associated with the risk of HNC, as is the MMP3-1171 5A>6A polymorphism specifically in some subgroups. However, the MMP9-1562 C>T polymorphism is not associated with HNC risk., Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients., the increase of MMP-1 and MMP-9 expression and low of TIMP-1 and TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC., These studies provide novel evidence that Dlx3 is involved directly in the transcriptional regulation of mouse and human MMP-9 gene expression in placental trophoblasts., The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas., Patients with metabolic syndrome show a significant increase in plasma MMP-9 levels., Analysis revealed a positive correlation between u-PA and MMPs and a negative correlation between u-PA/MMPs and TIMPs. These findings suggest the therapeutic potential of NM in treatment of adult sarcomas, Data indicate that a 2-week course of antibiotics and corticosteroids effectively improves the uterine environment underlying recurrent implantation failure (RIF) by reducing MMPs MMP2 and MMP9 activity., The levels of MMP2, MMP9, TIMP1, and TIMP2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those with benign thyroid disease and healthy volunteers., High mmp9 expression is associated with breast cancer., ATDC upregulates MMP-9 to promote lung cancer cell invasion by activating ERK and JNK pathways., Rs11908352 may influence joint destruction in rheumatoid arthritis via MMP-9 production., MMP3 and MMP9 were associated with ER-/PR- tumors., Data show that that the expression of Kiss1 Kiss1R and MMP9 were higher in the placenta compared to the placental bed and decidua parietalis., MMP-9 may have a role in survival in laryngeal squamous cell carcinoma, we analyzed MMP-1, MMP-9 and TIMP-2 expression levels in tumoral and non-tumoral compartments of prostate cancer specimens, Increased MMP9 and PLXNA2 expression in TMPRSS2, The blocking of MMP-9 and COX-2 signaling by inhibitors suppressed AR-enhanced cell migration and invasion., Suggest that miR-491 is involved in metastasis of hepatocellular carcinoma by blocking epithelial to mesenchymal transition and decreasing MMP2/9 levels., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells., Propofol decreases hepatocellular carcinoma cell invasiveness, which is partly due to the down-regulation of MMP-9 expression by miR-199a., These data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal role for PRL-dependent PAK1 tyrosyl phosphorylation in MMP secretion., The serum level of MMP9 in nasopharyngeal carcinoma patients was significantly higher than that in healthy controls., Upregulation of proteases MMP1 and MMP9 and inflammatory COX2 genes was found likely in response to soluble factors., Highest level of MMP-9 was found in patients with resectable pancreatic cancer., The effects of IL-5-induced cell responses were confirmed by transfection of IL-5 gene, which demonstrated that p21WAF1 participates in the induction of cell migration, leading to an increase in ERK1/2-mediated MMP-9 expression, WOX1 is involved in MMP9 induction, suggesting a novel role of WOX1 in Epstein-Barr virus-associated cancer progression, CEACAM1 controls matrix metalloproteinase-9 secretion by neutrophils in postischemic inflammation at the blood brain barrier after stroke., MMP-9 mRNA expression is upregulated in monocytes of peripheral blood in sleep apnea patients ., increased expression of MMP-9 metalloproteinases is responsible for disturbed equilibrium of the metalloproteinase/tissue inhibitors system and as a consequence, for destabilization of atherosclerotic plaque and occurrence of the acute coronary syndrome, MMP3 and MMP9 genes variant seem to contribute to the development of isolated systolic hypertension by affecting arterial stiffness and endothelial function, In conclusion, we suggest that the -1607 1G/2G MMP1, -1562 C/T MMP9, -511 C/T IL-1beta gene polymorphisms can be considered as an important risk factors associated with POAG., findings suggest that ILK promotes lung cancer cell migration and invasion via NF-kappaB-mediated upregulation of MMP-9, Ki-67 and matrix metalloproteinase-9 expression in the follicular cyst, keratocystic odontogenic tumor, and ameloblastoma, Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2,-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 cells., MMP-7 and MMP-9 immunostaining was significantly different between pathological and normal discs and correlated with the extent of histopathological degeneration., These data demonstrate that Bmi-1 plays a vital role in HCC invasion and that Bmi-1 is a potential therapeutic target for HCC, MMP-9 activity in cytotrophoblast cells is mediated by PGRMC1., Data suggest active form of vitamin D, 1,25-dihydroxy-vitamin D3, down-regulates expression of MMP2 and MMP9 in uterine fibroid/neoplastic cells; 1,25(OH)2-D3 inhibits activities of MMP2/MMP9 via up-regulation of TIMP1/2 (tissue inhibitors of MMPs)., the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population., High MMP-9 activity levels are associated with fragile X syndrome., a previously unrecognized correlation between the circulating MMP-9 and WBC levels in humans, MMP-9 plays a role in blood-brain barrier dysfunction, characterized by invasion of leukocytes into the cerebral spinal fluid during seizures, The above studies demonstrate that EGCG may exert at least part of its anti-invasive effect in ECV304 human endothelial cells by controlling MMP-9 expression through the suppression of ROS, NF-kappaB and AP-1, The second extracellular loop of CD9 was responsible for the upregulation of MMP-9 production., data imply that MMP-2 and MMP-9 activities may play a role in the pathogenesis of ventricular septal defect, Estrogen increased the expression of VEGF, and thus activate ERK1/2 pathway to induce MMP-2/9 expression., Report correlations between neuronal MMP9 and brain damage in alcoholics., MMP9 was upregulated in osteosarcoma., We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for MMP9, HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis, U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer, MMP9 may be involved in the development of airflow limitation in emphysema., MMP-9 may perform an important function in gastric ulcer formation and recurrence., Rab40b mediates trafficking of MMP2/9 during invadopodia formation and metastasis of breast cancer cells., the detrimental role of matrix metalloproteinase-9 during ischemic stroke treated with thrombolysis, and prompts clinical trials testing agents antagonizing its effects., Circulating MMP-2, -3 and -9 are independently associated with kidney disease progression in non-diabetic chronic kidney disease patients and add incremental predictive power to conventional risk factors., Extracellular vesicles are potent stimulators of MMP-9, IL-6, TGF-beta1 and induce the secretion of extracellular EMMPRIN, The MMP-9 rs17576 is a novel independent prognostic marker., Our results suggest that serum MMP-8, TIMP-1, and the ratio of MMP-9/TIMP-1 might be useful adjuncts as predictors of prognosis in patients with hepatocellular carcinoma, High MMP-9 expression is associated with cell invasion in renal cell carcinoma., Data suggest LCN2 (lipocalin 2) is involved in invasiveness of placental trophoblasts and choriocarcinoma cells, especially under hypoxia; these alteration appear to be mediated, in part, via increased activity of MMP9 (matrix metalloproteinase-9)., Expression of MMP-9 is increased in nasal polyp (NP) patients, and increased expression of MMP-9 is particularly found in the stoma of recurrent NP patients, which may contribute to the recurrence., Case Report, ta indicate that luteolin and quercetin attenuate the phosphorylation of cortactin and Src, disruption of invadopodia generation suppression of matrix metalloproteinase MMP9 secretion, and reduction in metastasis., Increased expression of MMP-9 was associated with ovarian cancer., Expression of S100A6 and MMP9 in combination is associated with the development of squamous cell carcinoma., Suggest role for coinfection with both C pneumonia and M pneumoniae in the development of aortic atherosclerotic aneurysms via MMP9/TIMP1., Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy., A higher expression of MMP-9 was found in tumor stroma of squamous cell carcinoma compared to basal cell carcinoma and actinic keratosis., Our studies show the significant role of MMP-9 in mobility and invasiveness of tumor cells, thus indicating a potential target point of interest for gene therapy., Results from Gene expression profiling show that LDLR, TP53, and MMP9 genes may play important roles in the development of atherosclerosis in a Malaysian study population., These results suggest that SIRT1 protects against COPD/emphysema, in part, via redressing the TIMP-1/MMP-9 imbalance involving TIMP-1 deacetylation., Data show a significant association between the C(-1562)T polymorphism in the atrix metalloproteinase-9 (MMP-9) gene and risk of Parkinson's disease and amyotrophic lateral sclerosis., The coexistence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in coronary artery disease patients., the effect of common MMP1 1G/2G, MMP3 5A/6A, MMP7 -181A>G, MMP9 R279Q, and MMP12 -82A>G polymorphisms on atherosclerotic plaque presence may be site- and sex-dependent, SNP -1562C>T in the promoter of the MMP-9 gene is associated with T2DM and DFU. An increased MMP-9 production from high expressing T allele may promote matrix degradation., By zymographic and Western blot analyses, Selaginella tamariscina extract was shown to inhibit the activities and expression of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells., Our findings indicate that S100A4 contributes to HCC metastasis by activation of NF-kB dependent MMP-9 expression., Letter, MMP2/TIMP2 and MMP9/TIMP1 immunoreactivity was extremely heterogeneous within the analyzed group of secondary liver tumors., Exhaled MMP9 was greater in asthmatics than in controls, and in patients with severe asthma compared to those with mild to moderate asthma., Determine a crucial role of LRP1-mediated Pyk2 phosphorylation on hypoxia-induced MMP-9 activation and hVSMC migration and therefore in hypoxia-induced vascular remodeling., Western blot analysis confirmed the results of gene expression analysis, but the up regulation of MMP1, -9, and -14 was donor-specific, The aim was to study fecal MMP-9 and HBD-2 in pediatric inflammatory bowel disease to compare their performance to calprotectin and to study whether they would provide additional value in categorizing patients according to their disease subtype., our present analyses did not show significant association between MMP SNPs and COPD risk in the whole population. However, we found TT genotype of MMP9 was a risk factor in the subpopulation with relatively worse lung function., MMP9 expression by neoplastic cells in classical Hodgkin lymphoma is associated with Epstein Barr virus positivity., The present study evaluated the serum levels of specific metalloproteinases (MMP-2 and MMP-9) and investigated the gene TGFBR in 28 patients with aortic valve disease associated with ascending aortic dilatation., suggests that binding of the HGF variants to the cell surface c-Met resulted in the downregulation of MMP-9, and upregulation of MMP-8 protein expressions might be key molecular signals against proliferation, migration, and invasion of A549 cells, Breast cancer progression is associated with upregulation of MMP-9 mRNA and protein expression., Components of the apoptotic signalling pathways and MMP-9 may play a role in rupture and labour., Brucella abortus induces collagen deposition and MMP-9 down-modulation in hepatic stellate cells via TGF-beta1 production., Showed that 1 mm melatonin dosage reduced IL-1beta-induced HepG2 cells MMP-9 gelatinase activity and inhibited cell invasion and motility through downregulation of MMP-9 gene expression., We found a significant association between MMP-9 rs11697325 polymorphisms and recurrent aphthous stomatitis., These data indicate that amsacrine induces MMP-2/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability in human leukemia cells., This is the first report demonstrating the dissociation of CCR7 and MMP-9 expression in phenotypically mature CD83(+) dendritic cells by cervical cancer cells, MMP-9 may play a role in the pathophysiology of schizophrenia and serve as a biomarker for schizophrenia., LCK phosphorylated Tyr-342 of FOXP3 by immunoprecipitation and in vitro kinase assay, and the replacement of Tyr-342 with phenylalanine (Y342F) abolished the ability to suppress MMP9 expression., Human head and neck cancer samples were positive for active MMP-9, which lends the tumor its gelatinolytic activity., HF also decreases the nuclear protein levels of nuclear factor kappa B (NF-kappaB) and c-fos (AP-1), critical transcription factors regulating MMP-9 expression through binding the MMP-9 promoter region, study provides a unifying molecular mechanism for high angiogenic capacity of TIMP-free proMMP-9, High MMP-9 expression is associated with increases in the invasiveness of laryngeal squamous cell carcinomas., Report elevated MMP-9 expression as least common denominator between varicocele, inguinal hernia, and chronic venous disorders., Elevated expression levels of MMP-9 in the chorionic villi was associated with prolonged bleeding after medical abortion., Salivary oxidative components and MMP9 salivary levels are useful in the detection and monitoring of children with epilepsy., Elevated CSF MMP-9 levels are associated with brain inflammatory reaction, disruption of the blood-brain barrier, and disease severity in tick-borne encephalitis., MDM2 overexpression induced MMP9 expression in a dose-dependent manner and is associated with a poorer prognosis in invasive ductal breast cancer., HOXA2 acts as a suppressor or TBP-antagonist to inhibit MMP-9 expression; while methylation-mediated inactivation of HOXA2 in NPC derepresses MMP-9 production and increases invasion of NPC cells., this study points to EGFR as a key mediator between CD9-mediated pro-MMP-9 release and cellular invasion of HT1080 cells., autocrine secretion of MMP-2/9 by brain microvascular endothelial cells induced by humoral factors, other than IgG, in sera obtained from neuromyelitis optica patients potentially increases blood-brain barrier permeability, The serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects., Activated hepatic stellate cells in the tumor microenvironment promote hepatocellular carcinoma cell migration and invasion via activation of FAK-MMP9 signaling., Bis knockdown resulted in a significant decrease in the migration and invasion of A172 glioma cells. Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression., MMP9 rs3918242 T allele was associated with higher LDL-cholesterol levels., We also demonstrated that the proteolytic processing of the gamma2 chain of laminin-332 was essential for its activity but that the N-terminal short arm of the gamma2 chain inhibited MMP-9 secretion, the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity. The present study indicates that MMPs have interactions spanning the P23-P23' subsites of collagenous substrates., In a coculture model of CD34(+) progenitor cells with platelets, we show for the first time that"diabetic" CD34(+) progenitor cells exhibit differences in differentiation to foam cells concerning growth characteristics and release of MMP-9., RSV is a potent stimulus for MMP-9 expression and release from human airway epithelium, The highest levels of MMP-2 and MMP-9 activities are found in the basal plate and extravillous trophoblast cells in women with undifferentiated connective tissue dysplasia., MMP-9/uPAR overexpression enhanced the potential of glioma cell migration and invasion., study concludes MMP-9 gene expression and MMP-9 -1562 polymorphism variants were associated with prostate cancer pathological stage and prognostic group, Despite earlier reports linking MMP-9 and TIMP-1 with prognosis in breast cancer patients there was no association between plasma levels and disease free survival., Amyloid-beta can regulate the proinflammatory state of human macrophages by inducing MMP-2/MMP-9/cathepsin S levels and by reducing TGF-beta1 secretion., Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells., MMP-9 expression was significantly higher in patients with higher levels of IL-8 and there was a significant positive correlation between IL-8 and MMP-9 expression., MMP-9 protein overactivation is a frequent and significant genetic event in laryngeal squamous cell carcinoma, correlating with its biological behavior (increased TNM stage)., there was a significant difference in MMP9 distribution between tooth agenesis in the maxilla and control individuals, Our results suggest the clinical importance of MMP-9 gene (Gelatinase B )polymorphism (-1562C > T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer., Soluble CD40 ligand stimulates the pro-angiogenic function of peripheral blood angiogenic outgrowth cells via increased release of matrix metalloproteinase-9., MMP-9 serum levels were consistently associated with markers of carotid atherosclerosis., Deletion of beta-catenin by siRNA abrogated celecoxib-induced inhibition of MMP9 up-regulation and E-cadherin down-regulation by treatment of PGE2 in A549 cell., Neither serum mature BDNF nor MMP-9 levels differed between patients with schizophrenia and controls., MMP-9 and dimer secretion levels correlated with the most aggressive cancer cell lines, Finasteride significantly downregulated MMP2 and MMP9 activities in RWPE-1 and PC3 cells and MMP2 in DU145 cells., Evaluation of urinary levels of MMP9, or the MMP9/Cr, MMP9/TIMP1, or MMP9/TIMP1/Cr ratios may help us to differentiate the newborns with hydronephrosis, FLNA may play important roles as a negative regulator to prostate cancer PC-3 cell by promoting the degradation of MMP-9., results suggest that the MMP-2-1306 C/T and MMP-9-1562 C/T polymorphisms are significantly associated with bladder cancer susceptibility, and no associations were found between MMP-9-1562 C/T polymorphism and bladder cancer susceptibility, data suggest that VEGF and MMP-9 play an important role in the malignant behaviour of gliomas, Hydroxytyrosol, at nutritionally relevant concentrations, reduces MMP-9 and COX-2 induction in activated human monocytes via PKCalpha and PKCbeta1 inhibition, MMP9 expression was differentially regulated by class I to III histone deacetylases in amnion cells., An association was found between MMP-9 stromal staining and survival in epithelial ovarian carcinoma., Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines, Thus the high MMP-2/MMP-9 ratio (> or = 1.8) may be associated with unfavorable course of AML., the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma, Significantly higher serum levels of MMP-2 and MMP-9 were found in breast cancer patients compared to patients with benign tumor., Provide strong evidence for an association between MMP-9 SNP rs2274756 and female thoracic aortic dissection risk in Chinese Han population., CTHRC1 expression is elevated in human colon cancer cell lines and clinical specimens, and promotes cancer cell invasivity through ERK-dependent induction of MMP9 expression., -1562C>T polymorphism may have association with coronary artery disease risk in Asian populations.[meta-analysis], High MMP9 expression is associated with pancreatic adenocarcinoma., hypothesize that MMP-9 and CXCL8/IL-8 causally contribute to blister formation, and inhibition of these two factors could be of therapeutic benefit, serum concentration tends to increase during pregnancy in normal and preeclamptic pregnancies, MMP-9 expression is associated with primary tumor tissue, adjacent mesenchymal tissue, and the metastatic site in colorectal cancer., High MMP9 expression is associated with breast cancer., Data indicate that silencing of alpha-fetoprotein led to an increased apoptosis, which was associated with a decreased expression of vascular endothelial growth factor, vascular endothelial growth factor receptor 2, matrix metalloproteinases-2/9., miR-21 might be a biomarker for plaque instability by suppressing target gene RECK to promote the expression and secretion of MMP-9 in macrophages, MMP-9 C1562T polymorphism was significantly related to CAD in East Asians., Data suggested that IL-6 mainly promotes the cell migration and invasion of Nasopharyngeal carcinoma cells; the effect of IL-6 on cell migration and invasion may be mediated through regulation of the expression of MMP-2 and MMP-9., Icaritin suppresses the proliferation of SaOS2 human osteosarcoma cells by increasing apoptosis and downregulating MMP2/9 expression., Heterogeneity among serum MMP-2 and MMP-9 isoforms and their charge variants was found in sera of multiple sclerosis patients., FLAIR ratio correlates with both MMP-9 level and risk of cerebral hemorrhage., DLK1 can promote the invasion of lung cancer cells by upregulating MMP9 expression, which depends on Notch signaling, Expression of a specific MMP-9 mRNA is affected by a highly selective miRNA interaction with the single nucleotide polymorphism containing-mRNA., These results suggest that LPA5 may act as a negative regulator of cellular responses in mouse fibroblast 3T3 cells, similar to the case for LPA1., this study identified a novel role of the cleavage form of NCL generated by MMP7 in stabilizing MMP9 mRNA., Glabridin inhibits helatocellular carcinoma cell migration/invasion by down-regulation of MMP9 expression via NF-kappaB/AP-1 pathway., Circulating OGN and NGAL/MMP9 complex are promising biomarkers that are expressed in vulnerable atherosclerotic plaques and may have incremental value for prediction of MACE within 1 year after coronary angiography., MMP-9 deletion improves angiogenesis, attenuates inflammation, and prevents vascular leakiness in the setting of cardiac aging., results suggested that overexpression of CRKL promoted cell invasion through upregulation of MMP9 expression and activation of ERK pathway, There were significant positive associations between COX-2, MMP-9 and VEGF expression and age (>45 years), clinical stage (III-IV) and tumor diameter., Melittin inhibits EGF-induced tumor invasion by suppressing MMP-9 expression and FAK phosphorylation in breast cancer cells., The presence of active MMP-9 in mycetoma patients suggest that MMP-9 is activated or synthesized by inflammatory cells upon Madurella mycetomatis infection., the imbalance between serum MMP-9 and TIMP-2 levels could have a role in disease progression in patients with mRCC under treatment with sunitinib, Evaluation of the microvessel density and the expression of MMP2 and MMP9 and TTF1 in the different subtypes of lung adenocarcinoma in Tunisia, MMP-2, MMP-9, and E-cadherin are expressed in the endometrium of infertile patients during the receptive phase of the natural menstrual cycle. However, there is no correlation between the expression of these molecules and the clinical IVF outcomes., Endogenously produced MMP-9 has a role in regulation of tissue contraction of 3D collagen gels mediated by fibroblasts., expression of a constitutive nuclear form of FoxO1 significantly inhibited MMP9 activation induced by EGF, these findings suggest that AEG-1 contributes to CRC invasiveness and metastasis by enhancing MMP9 activity, Serum PTX3, MMP-9 and C-reactive protein expression was significantly higher in the acute coronary syndrome patients compared with controls., Spearman's rank tests showed that MMP-2/9 activities in cardiac tissue obtained before CPB were positively correlated with postoperative cTnT serum levels, microRNA-133b downregulation and inhibition of cell proliferation, migration and invasion by targeting matrix metallopeptidase-9 in renal cell carcinoma., E-cadherin and MMP-9 expression at histologically negative surgical margins shows the significance of these markers for prognostic values in oral squamous cell carcinoma patients., non-surviving septic patients showed persistently higher TIMP-1/MMP-9 ratio than survivors ones., P6 is a novel sequence in PEX9 involved in cell-PEX9/(pro)MMP-9 binding by interacting with CD44., The possible role of MMP-9 and MMP-2 on the expression of soluble CD154 (sCD154) and membrane-bound isoform of the CD154 in Iranian multiple sclerosis patients, was examined., MMP9 overexpression is associated with glioma., E2F1 acts as a transcriptional activator for MMPs and directly enhances MMP transcription (MMP-9 and MMP-16) by binding to E2F1 binding sequences in the promoter., Poly(I, MMP-9 and galectin-3 could be used as a guide for prognosis of hepatocellular carcinoma (HCC) since they may play a role in HCC progression and metastasis, These data demonstrate that the exposure of neutrophils to allergens leads to generation of MMP-9, which may then lead to remodelling in asthma., The genetic variations of MMP9 gene were not significantly associated with ICH susceptibility in the Chinese Han population., These results indicated that shikonin induces the suppression of migration and invasion through modulation of MMP-9 in human breast cancer cells, MMP-9 correlates better with inflammatory and angiogenic parameters in Crohn's disease than in ulcerative colitis., That expressed considerable amount of MMP-2 and MMP-9., High expression of mmp9 causes increased angiogenesis in Ewing Sarcoma., High MMP9 expression is associated with metastasis of basal-like triple negative breast cancer., Increased plasma levels of MMP-9 are associated with ischemic stroke., SDF-1/CXCR7 enhances ovarian cancer cell invasion by upregulation of MMP-9 expression., probe activation for a MMP-2/9 responsive radiolabeled ACPP probe occurred already in the vasculature early after systemic administration, followed by nonspecific uptake in subcutaneous tumors that is comparable for high and low MMP-expressing tumors, Data indicate that chronic myelogenous leukemia blast crisis showed that MMP-9 was highly expressed in three, with two exhibiting high levels of HES1 expression., Authors show that increased synthesis of MMP9 at the leading edge of migrating epithelium is regulated by galectin-3., CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression independently of the PI3K/AKT pathway., no evidence for significant association between MMP9-1562C>T polymorphism and risk of pre-eclampsia [meta-analysis], Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas, MMP-9 was overexpressed in breast cancer specimens compared with peritumoral benign breast epithelium and lymph nodes., MMP-9 concentration in the CSF of TBI patients correlated with neurological outcome., The tissue and serum levels of MMP-9 were associated with histology grade, lymph node status, pathological stage, and lymphovascular invasion in breast cancer patients., Data show that overexpression of miRNA-181c in A-172 glioblastoma cells inhibited matrix metalloproteinase-9 (MMP9) expression by inhibiting Akt phosphorylation, but not phosphorylation of epidermal growth factor receptor (EGFR) receptor., S100A4/NFkB/MMP-9 signaling pathway may play an important role during laryngeal squamous carcinoma cell invasion., AT1 A1166C independently and in combination with MMP9 R668Q and NFKB1-94 ATTG ins/del polymorphisms plays important role in conferring genetic susceptibility to LVD in CAD patients., The genetic variations of MMP9 gene were not significantly associated with ICH outcome at 90 days in Chinese Han population., Studied the effect of matrix metalloproteinase-9 overexpression on clinical outcome of gastric cancer using a meta-analysis., By reducing MMP-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways., expression of stromal MMP-2 alone, as well as coexpression of stromal MMP-2 with tumoural MMP-2 or -9, correlates significantly with prognostic predictors in breast cancer patients, Data indicated that CCR7 regulates cell chemotaxis and migration via MMP-9 in metastatic squamous cell carcinoma of head and neck., Oral squamous cell carcinoma patients with low Shh, Gli-1 and MMP-9 expression survived longer than those with high expression.Shh signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression., expression of MMP-2 and MMP-9 proteins increased with the degree of extra-gastrointestinal stromal tumor metastasis risk., In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated., MMP-9 induces drug resistance by modulating proteins of the Bcl-2 family and upregulating the corresponding anti-apoptotic/pro-apoptotic ratios., CGP may inhibit migration and invasion in HT1080 cells through the urokinase plasminogen activator (uPA)-uPA receptor signaling pathways to inhibit MMP-2 and MMP-9., MMP-9 gene expression was significantly increased in the secondhand smoke and active smoking groups, No risk factors influenced local levels of MMP-9. MMP-2 could contribute significantly to the increased AAA growth rate observed in current smoking patients., Women exposed to biomass combustion have increased serum levels of MMP9., MMP-9 derived from rheumatoid arthritis synovial fibroblasts may directly contribute to joint destruction., Down-regulation of NDRG1 in gastric cancer metastatic progression was correlated to E-cadherin and MMP-9., upregulation of MMP-2 and MMP-9 and downregulation of TIMP-1, is one of the mechanisms by which Skp2 promotes cell invasion of human renal cancer cells, Fascin and MMP-9 proteins are associated with parameters of poor prognosis in breast cancer, High MMP9 expression is associated with non-small cell lung cancer., UV radiation emitted by the solar simulator was able to stimulate the cells from extracellular matrix in in vitro culture to TGF-beta production, MMP-2 and MMP-9 expressions and their mRNAs., Letter, Results suggest that increased MMP-9 activation in the brain of 5xFAD mice enhances alpha-secretase cleavage of APP, leading to increased release of neurotrophic sAPPalpha, reduces Abeta-oligomers and promotes the proteolytical maturation of BDNF, Our results indicated that MMP-9-1562 C>T polymorphism was not a risk factor for stroke., Follicular fluid gelatinase activities, particularly MMP-9 activity, might be a predictor of oocyte quality and IVF success., our finding suggests that both MMP-2 and MMP-9 expressed by synoviocytes as well as certain infiltrating immune cells role figure importantly in the angiogenesis in rheumatoid arthritis progression., these findings suggest that dysregulations of RECK and RAGE expressions may be collectively involved in tumor progression of nasopharyngeal carcinoma by regulating MMP9 expression, MCP-1 stimulates secretion of MMP-9 directly through the ERK1/2 and p38 MAPK mediated pathways in HASMCs, Eight PAC-1 and five isatin derivatives were docked into MMP-9 and MMP-14. The same compounds were synthesized, characterized, purified and tested as inhibitors of MMP-9 and MMP-14, using fluorescence quenched peptide and biological substrates., In vitro incubation of functional HDL with MMP-9 provided direct evidence for the association of MMP-9 with HDL and the role of MMP-9 in HDL dysfunction. This enhances the risk of cardiovascular disease in subjects with dysfunctional HDL., There was an interaction between two alleles of MMP-7 G and MMP-9 T that significantly increased the risk of severe preeclampsia by 1.4-fold, our study demonstrated that Nur77 could promote the invasion and metastasis of colorectal cancer cells through regulation of MMP-9/E-cadherin signaling, MMP-9 levels were associated with left ventricular dysfunction in spinal cord injury patients., MMP9 serum levels were significantly increased in chronic Chagas heart disease patients compared to controls., local high (pro)MMP-9 expression may contribute to malignant cell retention in lymphoid organs and disease progression., Abeta25-35 can induce the release from human neutrophils of pro-MMP-9, a metalloprotease involved in the onset of inflammation, Increase in MMP9 levels are associated with metastasis of non-small cell lung cancer., Studied axillary lymph node (ALN) metastasis of early breast cancers by evaluating the status of DARC, D6 and CCX-CKR and the levels of VEGF and MMP-9., Overexpression of MMP9 is associated with ameloblastoma., Data indicate that the mRNA and protein expressions of extracellular signal-regulated kinase 1/2 (ERK1/2) and and matrix metalloproteinases MMP-2 and MMP-9 were significantly decreased by baicalein., this meta-analysis suggests MMP-9 is potently associated with high grade and poor 5 years prognosis., Dihydromyricetin inhibits migration/invasion of hepatoma cells in vitro by down-regulating MMP-9 levels., NOX2 is involved in the pathogenesis of human emphysema and macrophage-specific NOX2 participates in elastase-induced emphysema through the involvement of sirtuin 1/metalloproteinase-9 pathways in mice, a-Solanine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), Upregulation in mmp3 is associated with ovarian cancer cell invasion., syndecan 4 is the predominant heparan sulfate proteoglycan in the glomerular endothelial cells glycocalyx, Our data suggest that MMP-9 and VEGF are key therapeutic targets of EGCG for treatment and prevention of ocular angiogenic diseases such as age-related macular degeneration, diabetic retinopathy, and corneal neovascularization., MMP9 overactivation in idiopathic dilated cardiomyopathy was higher in non-rafts compared to the amount in lipid rafts., MMP3 may be the recommended urinary metalloproteinases as early diagnostic biomarker in the early stages of both types of bladder cancer although both MMP9 and MMP3 can be used in the diagnosis of advanced stages., beta6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells., these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-->miRNA-541-->AR-->MMP9 signaling., we proved that FOXA2 repressed the transcription of matrix metalloproteinase (MMP)-9 and exerted its antimetastasis effect partially through downregulation of MMP-9., Differential expression of MMP-9 reflects the extent of cellular differentiation in breast cancer cells and is closely related to the most aggressive subtypes of breast cancer., Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclear cells and elevated depressive symptoms represent two unrelated phenomena after myocardial infarction., No evidence was found to support an association between the MMP9 gene variants and susceptibility to either age-related macular degeneration or polypoidal choroidal vasculopathy in a Chinese Han population., Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts., CaMKII promotes gastric cancer cell metastasis by NFkappaB and AktmediatedMMP9 production., The overexpression of N-cadherin in two oral squamous carcinoma cell lines increased motility, invasive capacity and synthesis of matrix metalloproteinase-9 (MMP-9) in a manner that was independent of E-cadherin downregulation., RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis., Experiments using peripheral blood mononuclear cells (PBMCs) from Crohn's disease patients with nonfunctional NOD2 showed that MMP-9 induction by Streptococcus pneumoniae and MDP is NOD2 dependent., Data shows that in coronary artery disease patients with metabolic syndrome, the MMP-9 T-allele increased the risk of clinical events, probably mediated through elevated MMP-9 levels and altered MMP-9 regulation., findings provide the first evidence that FSL-1 induces TLR-2-dependent MMP-9 gene expression which requires the recruitment of MyD88 and leads to activation of MEK1/2 /ERK 1/2, MEK5/ERK5, JNK, p38 MAPK and NF-kappaB/AP-1, HSP60 overexpression was associated with the disease progression and prognosis in gastric cancer, and its expression significantly correlated with the expression of MMP-9., The results suggest that a higher serum level of MMP9 in the presence of MMP9 polymorphism -1562 C, Esophageal cancer stem cells express PLGF to increase cancer invasion through MMP9 activation., The differential expression of ROCK-1 and MMP-9 proteins suggests their potential use as prognostic markers in breast cancer., miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9., found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9., switch from alphavbeta5 to alphavbeta6 integrin plays a key role in CD9-regulated cell migration and MMP-9 activation in keratinocytes, miR-34a plays an important role in lymph node metastases of tongue squamous cell carcinoma through targeting MMP9 and MMP14., These results suggested that PFIO could suppress the invasion and migration of human lung carcinoma by reducing the expression levels and activity of MMP-2 and MMP-9 via suppression of MAPKs, PI3K/AKT, and NF-kappaB signaling pathways., elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates NK cell dysfunction., Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis., concluded that patients with the MMP-9 TT genotype are at risk of developing HCC and HBV or HC, MMP-2, MMP-9, MMP-7 and TIMP-2 were upregulated in primary spontaneous pneumothorax lesions., High MMP9 expression enhanced hepatoma cell invasion and migration., In cases of preeclampsia, the least expression of MMP-2 and MMP-9 is recorded in IC and MGCs in the complete absence of intravascular cytotrophoblast, Celastrol dose-dependently suppressed TNF-alpha-induced MMP-9 gene expression at both the mRNA and protein levels in breast cancer cells., Pretreatment with statin can inhibit the thrombolysis-induced increase in plasma MMP-9 levels but does not significantly affect the prognosis of acute ischemic stroke patients undergoing intravenous thrombolysis., Modulation of MMP-9 expression (and Slug signaling) through ERK5 knockdown resulted in inhibition of tumor invasion in osteosarcoma cells., High tissue MMP-9 levels were associated with higher staging and lymph node metastasis in breast cancer., The most potent inhibition of RANTES, eotaxin and eotaxin3 as well as MMP9 activity., the antiangiogenic effects were substantially enhanced when the agents were combined which may due to the reduced expression of VEGF and matrix metallopeptidase-9 (MMP-9) in tumor tissues, We show that WAVE3-mediated modulation of NFkappaB is required for invadopodia formation as well as MMP9 expression and activity that are needed for cancer cells to degrade the ECM, The combination of serum S100A9, SOD3, and MMP9 levels could achieve 92.5% sensitivity and 95% specificity to discriminate between pulmonary tuberculosis and healthy controls., Overexpression of MMP-9 in lung tissue and its interaction with CAP1 is likely to play a major role in airway obstruction in chronic obstructive pulmonary disease., These findings indicate that investigated biomarkers are constructive for early diagnosis of breast cancer and MMP-9/TIMP-1 ratio might be a new significant marker in predicting breast cancer development., LOX may play a role in the metastasis of non-small cell lung cancer by promoting MMP2/MMP9 expression., Overexpression of MMP-9 is a valuable independent prognostic indicator in hilar cholangiocarcinoma., MMP-9 is increased and TIMP-1/-2 is reduced in the most common forms of thoracic aortic aneurysms., Our results show that proMMP-9 trimers constitute a novel structural and functional entity that is differentially regulated by TIMP-1., Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment., The association between 3 single-nucleotide polymorphisms (SNPs; MMP1 -1607 1G/2G, MMP3 -1612 5A/6A, and MMP9 -1562 C/T) and the risk of esophageal squamous cell carcinoma, were analyzed., TNF produced in high level during Cutaneous leishmaniasis (CL) contributes to MMP-9 production. These observations emphasize the role of monocytes, TNF and MMP-9 in the pathogenesis of Leishmania braziliensis infection., MMP-2, MMP-9, TIMP-1, and TIMP-2 may have important roles in the development and progression of MFH., results of the current study suggest that expression of MMP9 and VEGFR2 is associated with epithelial dysplasia grading and MMP9 levels are increased in oral squamous cell carcinoma., role in development of arterial aneurysms, VEGF-alpha, MMP-2 and MMP-9 may play a role in colorectal tumorigenesis, Results demonstrated that the p38 MAP kinase signaling pathway is essential for MMP-9 upregulation in pericytes in response to TGF-beta1 stimulation, In fragile X syndrome patients, phosphorylation of the mRNA 5' cap binding protein, eukaryotic initiation factor 4E (eIF4E), is elevated concomitant with increased expression of matrix metalloproteinase 9., Urinary Emmprin, MMP-9 and TIMP-1 may be noninvasive potential biomarkers that could be used for long-term follow-up of children with UPJ narrowing on conservative treatment to determine those who might develop obstruction., a possible coordinated role of VEGF-A and MMP-2 during uterine leiomyomas growth and angiogenesis with potential prognostic significance, DNA methylation at the promoter region of MMP-9 gene can enhance the expression of MMP-9 in ectopic endometrial stromal cells of endometriosis., Lower serum E2 levels were detected in healthy women with the MMP-2 -1575GA+AA/MMP-2 -1306CT+TT and MMP-2 -1306CT+TT/MMP-9 2678GG combination genotypes. MMP9 polymorphisms alone were not associated with primary ovarian insufficiency in Korean women., in the first three days of intracerebral haemorrhage, serum MMP-9 values were rising as well as the neurological deficit and the brain edema, In patients of spinal tuberculosis, poor outcome is associated with higher pro-inflammatory serum TNFA and IFNG, and CSF MMP9 levels, and a lower anti-inflammatory serum IL-10 level, Patients were followed from the time of primary surgery until death or last follow-up until December 2012. Lipocalin-2 and matrix metalloproteinase-9 were highly expressed in high-grade endometrial cancer., No evidence to support the association of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth in European Caucasian women., Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak2 and Stat3 pathway, Multivariate analysis revealed significance for overall survival in NGAL expression and No differences in overall survival were found for expression of MMP-9, Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9, MMP-8, MMP-9, and YKL-40 might serve as novel non-invasive biomarkers of CF lung disease and pulmonary exacerbations., we found that miR-373 and -520c down-regulated the activities of MMP2 in various cancer cell lines but simultaneously up-regulated the expression of MMP9 gene only in HT1080 cells, During the Barrett's pathogenesis process, MMP activity is increased early on in the inflamed esophagus and remains high in metaplasia and esophageal adenocarcinoma. However, there is a switch of MMP13 to MMP9 expression once neoplasia develops., Fecal MMP-9 did not correlate with any of the activity indices of Crohn's disease; however, strong associations were shown between fecal MMP-9 and clinical, endoscopic, and histologic activities of both ulcerative colitis and pouchitis., High urine MMP9 levels are associated with gastric cancer., High MMP9 expression is associated with lung cancer., Upregulation of PRMT7 in breast cancer may have a significant role in promoting cell invasion through the regulation of MMP9., The expression of MMP-7, -8, -9 and -13 in the gingiva of the young patients with aggressive periodontitis and type 1 diabetes mellitus was positive in all studied cases., The present study investigated changes of circulating metalloproteinases (MMP-3, MMP-9) and CRP levels in patients with ulcerative colitis and Crohn's disease., These studies show that multiple MMPs are present in the genital tract of women and strongly suggest that MMP-9 in genital secretions can cleave IL-8 at this mucosal site., Novel protein biomarker models improve identification of 10-year MI risk above and beyond traditional risk factors with 14% better allocation to either high or low risk group., serum MMP-9 could be an early marker that discriminates MI from UA and predicts poor outcome in terms of disease severity and extent of disease complications., These results indicate an intimate relationship between MMP9 overexpression and vasculogenic mimicry formation in renal cell carcinoma, IHC staining showed higher TR4 level, more macrophage infiltration, lower TIMP-1 and stronger MMP2/MMP9 in tumor tissues., Ara-C enhances the invasiveness of gastric cancer cells by expression of CD-147 /MMP-2 and MMP-9 via the ERK signaling pathway., Data shows that RIG-I is downregulated in hepatocellular carcinoma cells (HCC) and loss of its expression is correlated with poor prognosis. Also, RIG1 regulates cell migration and invasion thorough downregulation of MMP9 expression in HCC cells., SMYD3 and MMP-9 may play important roles in tumor invasion, metastasis, and prognosis and could work as promising targets for prognostic prediction in gastric cancer., these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases, Both HER2 and MMP-9 may be required to effectively block HER2 signaling in gastric cancer therapy., Increased Pak4 expression can lead to development of adenomyosis by enhancing the invasiveness of endometrial cells through regulation of MMP-2 and -9 activities., the current study showed that MMP-9 polymorphisms contributed significantly to BD., Cyclosporine A treatment reduced MMP9 and inflammatory cytokine levels in an in vitro inflammation model system. In KC patients, CyA treatment reduced MMP9 levels measured in tears with concomitant arrest of disease progression., high levels in exhaled breath condensates of asthma-suffering children correlates with IgE serum levels, inhibiting heat shock transcription factor 1, which links temperature and peripheral clock-gene oscillations, inhibited MMP-9 but not MMP-2 temperature-driven MMP cycling., The expression level of GOLPH3 is correlated with metastasis and prognosis in NSCLC, and GOLPH3 mediates metastasis by regulating the protein levels of MMP-2 and MMP-9 in vitro., Biosensors were produced by coating electrodes with oxidized dextran and subsequent cross-linking with peptides containing specific cleavage sites for MMP-9., Meta-analysis published data and this study showed that multiple sclerosis not affected by single nucleotide polymorphisms in the MMP9 gene., These results suggest that Porphyromonas gingivalis activates PAR4 signaling pathways, leading proMMP9 over-expression and cellular invasion in oral squamous cell carcinoma cells., Report imbalance between MMP-9 and TIMP-1 levels in prostatic adenocarcinoma which may contribute to neoplasm invasiveness., MMP9 gene -1562 C/T polymorphism is associated with polycythemia vera., HMGB1 induced lung fibroblasts' differentiation into myofibroblasts and enhanced cell migration through induction of MMP-9 activation and the RAGE-MAPK and NF-kappaB interaction signaling pathways, Data suggest that changes in DNA methylation in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4), and (3) matrix metalloproteinase (MMP2 and MMP9) activity., Data indicate that the enzymatic activity of MMP-2 and MMP-9 on dystroglycan plays a significant role in muscular dystrophies and also in physiological processes taking place in the central and peripheral nervous system. review], An important role for MMP-9 activated by NADPH/reactive oxygen species signaling pathways in regulating high glucose-induced MUC5AC expression., We found significant differences in the incidence of particular MMP3 and MMP9 alleles, which substantiate the role of matrix metalloproteinases in EGE pathogenesis., miR-129, EGFR, and MMP9 appear to be promising therapeutic targets for preventing the metastasis of non-small cell lung cancer, MMP-9 expression is more important for primitive alveoli differentiation., pretreatment of gastric cancer cells with NTR1 inhibitor SR48692 was shown to significantly inhibit the NT-mediated MMP-9 activity, cell invasion, and migration, MMP-9 -1562T allele is a risk factor for breast cancer., These results suggest that MMP-9 is an ovarian cancer-associated gene and is a potential target for therapeutic anti-cancer drugs, MMP9 was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells. Knockdown of HEY1 decreased the expression of MMP9., High serum mmp9 levels are associated with Squamous cell carcinoma., MKL1 recruited ASH2, a component of the H3K4 methyltransferase complex, to activate MMP9 transcription., Reactive oxygen species increase the activity/levels of gelatinolytic matrix metalloproteinases, and stimulate cytokine secretion in human periodontal ligament fibroblast., MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA., japonicus was able to inhibit the expression of MMP-2 and MMP-9 and suppress the transcription and translocation of iNOS and COX-2 by directly inhibiting the activation of NF-kappaB and the phosphorylation of the MAPK pathway, in a homogeneous cohort of women with high-grade serous carcinoma, increased MMP-9 tissue expression, as assessed by automated immunostaining quantification, was associated with a higher risk of death, In salivary adenoid cystic carcinoma cells, WIP1 silencing reduced MMP-9 expression. Overexpression of VEGF-C restored migration and invasion in WIP1 knockdown cells., LR1 contributes to hypoxia-induced migration and invasion of trophoblast cells at least partly by mediating MMP-9, The results of the research showed, that there is no connection between the capital ES, Cyrillic-1562capital TE, Cyrillic polymorphism of the MMP-9 gene and the progression of leiomyoma the course of which is accompanied by false erosion of the cervix, Progestins may prevent fetal membrane weakening by preventing TNF-alpha induction of MMP9 gene expression/activity., A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M., we found that some breast cancer diagnosis-associated features such as tumor size, tumor grade, estrogen receptors (ER) and progesterone receptors (PR) levels, were correlated well with TSP50/p65 and TSP50/MMP9 expression status, western blot analysis showed that ophiopogonin-D inhibited the expression and secretion of matrix metalloproteinase-9 (MMP-9), but not that of MMP-2., Single nucleotide polymorphism-1562C/T of MMP9 may not be associated with IVF-ET outcome., We propose that the role of myeloid angiogenic cells with cell surfaces expressing MMP-2/9 is rapidly invading ischemic tissue., Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas., MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association., MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation, MMP-9/ANC score before PCB treatment may be a suitable biomarker to assess the anti-tumor effects of PCB therapy., This commentary critically reviews these findings based on the hypothesis that MMP-9 contributes to pathological synaptic plasticity in schizophrenia. [review], Increased serum MMP-9 concentrations in COPD indicate an enhanced proteolytic activity that is related to disease severity., Neutralization of MMP activity by antibodies to MMP2/9, broad-spectrum MMP inhibitor or selective gelatinase inhibitor resulted in significant suppression of HGF-induced EMT and cell migration/invasion., Data indicate the existence of inter-ethnic variation of matrix metallopeptidase 9 (MMP-9) microsatellite (-90 (CA)12-27)., D90 significantly inhibited the invasion and metastasis of OSCC cells by decreasing the expression of sp1 and increasing the expression of RECK to suppress the expression and activity of MMP-2 and MMP-9., Among patients with non-small cell lung cancer, tumor MMP-9 expression was associated with poor outcomes in those with adenocarcinoma, but not in those with squamous cell carcinoma., TT genotype of MMP-9-1562 C/T polymorphism might be a risk factor for breast cancer., recombinant human (rh) MMP-2 and MMP-9 were incubated with Abeta40 and Abeta42, and the resulting proteolytic fragments were assessed via immunoprecipitation and quantitative mass spectrometry, mangiferin regulates proliferation and apoptosis in glioma cells by induction of miR-15b and inhibition of MMP-9 expression, USP22 attenuated the invasion capacity of colon cancer cells by inhibiting the STAT3/MMP9 signaling pathway., MMP9 gene Gln279Arg polymorphism was associated with ESSENTIAL THROMBOCYTOSIS, POLYCYTHEMIA VERA, and IDIOPATHIC MYELOFIBROSIS, This study showed modest to moderate effects of MMP-9 and TIMP-1 polymorphisms on spontaneous deep intracerebral hemorrhage risks with significant age differences., No evidence was found for the association between the functional MMP-9 -1562C/T gene polymorphism and deficit/non-deficit subtypes of schizophrenia., intestinal microbes with the capacity to produce collagenases and to activate host metalloproteinase MMP9 may break down collagen in the intestinal tissue contributing to anastomotic leak, Interestingly, endotoxin tolerance significantly upregulated TIMP1 relative to MMP9 and downmodulated MMP9 secretion and its enzymatic activity., DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA and MMP9 mediated by suppression of the transcription factor FOXM1, MMP9 -1562 CC genotype was associated with esophageal cancer., Higher CD147 and MMP-9 expression rates were correlated with inferior postsurgical survivals in adenocarcinoma of esophagogastric junction., MMP9 is a direct target of miRNA-204 as demonstrated with dual-luciferase assay. MiRNA-204 inhibits trophoblast-like cell invasion., Studied if circulating TGFbeta1 drives changes in tight junction protein expression and MMP9 activity following acute liver failure; Mouse brain endothelial cells were treated with recombinant rTGFbeta1 and MMP9 and claudin-5 expression was assessed., plasma MMP-9 activity changes, as a surrogate for primed neutrophils may have a role in Acute Respiratory Distress Syndrome, The results show that esophageal cancer-derived microvesicles are LAMP1 positive and carry MMP9., Polymorphism 1562 C > T (rs3918242) is associated with protection from placental malaria falciparum., We found that expression of Gab1, VEGFR-2, and MMP-9 was highly and positively correlated with each other and with lymph node metastasis and TNM stage in intrahepatic cholangiocarcinoma tissues, gene expression analysis of human breast tumors showed that high expression of IGFBP mRNA was strongly correlated with good prognosis but not when MMP9 mRNA was also highly expressed, we found that overexpression of PLGF in TT cells increased expression of MMP9, while inhibition of PLGF in TT cells decreased expression of MMP9., both populations exert distinct proteolytic activities, being the IL-10-stimulated macrophages the most efficient in inducing matrix metalloprotease (MMP)-2 and MMP-9 activities., Aurora kinases ((Aurora kinase A and B )mediate PKC-MAPK signal to NF-kappaB/AP-1 with increasing MMP-9 expression and invasion of MCF-7 cells., PM10 from commercial zone up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/beta-catenin expression after 48 h of exposure., data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages, IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner., LiCl significantly increased nuclear b-catenin, resulting in MMP9 activation in BC cells. IWP-2 significantly decreased nuclear b-catenin, resulting in MMP9 inhibition in BC cells. MMP9 regulated cell invasiveness., Because MMP-9 expression is significantly increased in invasive prolactinomas, MMP-9 has potential as a marker for invasion, MMP9 was not associated with echocardiographic parameters of new-onset heart failure., Our findings suggest GOLPH3 regulate MMP9 expression which impact cell migration and invasion in prostate cancer cell lines., Both MMP9 rs3918242 and MMP2 rs243865 are associated with risk of NAFLD. MMP9 rs3918242 and central obesity have synergistic effects on risk of NAFLD., c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoural stroma of hepatocellular carcinoma., Patients with Primary Open-Angle Glaucoma are characterized by an increased mRNA expression of MMP1, MMP9, MMP12, TIMP1 and IL-1b genes as compared to the control group ., A statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells., Significant activation of MMP9 takes place in COPD and emphysema patients., This downregulation of RECK in advanced grades of osteosarcoma and metastatic grades was also associated with the increased expression of invadosome-specific markers like MMP9, The frequencies of MMP9 alleles and genotypes did not differ significantly between patient and control groups., salivary levels of the analyzed biomarkers MMP-8, -9, MPO are associated with periodontal status. However, these biomarkers could not differentiate between patients with or without a MI., The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period, MMP-9 secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1., The results suggest that AQP1 may facilitate lung cancer cell proliferation and migration in an MMP-2 and-9-dependent manner., B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer, the results of the study did not point toward a major role of the MMP-9 -1562C/T polymorphism in the pathogenesis of gastric cancer in Turkish subjects, Metformin suppressed OS MG63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (MMP2) and MMP9, MMP-9 may be a possible marker of atheromatous plaque rupture in diabetics. Statically significant differences in MMP-9 were found between the controls and the diabetics with ACS and between controls and non-diabetic patients with ACS., Decreased invasion partly resulted from reduced expression and activation of MMP-9 after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo., Data indicate that elevated expression of microRNA-375 in head and neck squamous cell carcinoma (HNSCC) cells significantly reduces kallikrein 6 (KLK6), kallikrein 10 (KLK10), and matrix metalloproteinase 9 (MMP9) messenger RNA expression., These results indicate that our hydrophilic extract from P. oceanica might be a source of new pharmacological natural products for treatment or prevention of several diseases related to an altered MMP-2 and MMP-9 expression., Evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. MMP9-1562 T gene mutation might reduce the risk of diabetic nephropathy., We aimed to provide a theoretical basis for improving patient prognosis through analyzing expression of plasma brain natriuretic peptide (BNP), endothelin-1 (ET 1), and matrix metalloproteinase 9 (MMP-9)., E6-HPV16/E7-HPV16 promoted the activity of MT1-MMP and MMP-2/9, contributing to the migration of cervical cells and neoplasm invasiveness., the confirmation of MMP-9 and TIMP-1 value as prognostic factors, based on immunohistochemical expression, requires a threshold validation., Genes expression of MMP9, VEGFA and TIMP1 in peripheral blood leukocytes may play a pivotal role in regulation of progression of bladder cancer; TIMP1 expression may be important factor for early recurrence., The secretion of embryonic MMP-9 is closely related to the quality of the embryo and embryo implantation., Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K., Data show that both AMPKalpha cleavage and MMP9 expression are required for Toll-like receptor 4 (TLR4)-mediated mTORC1 activation and HIF-1alpha expression., the C-1562T SNP in the promoter region of the MMP-9 gene, the GSTT1 null, as well as the combined GSTM1 non-null and GSTT1 null genotypes are modulators of temporomandibular disorders risk in a Serbian population, MMP9 plays a role in development of intra-cerebral-hemorrhages in the setting of cerebral amyloid angiopathy., Study showed that the MMP9 activity was upregulated by LCN2, and both LCN2 and MMP9 are controlled by the NFkappaB pathway which results in progression and invasion of two gastric cancer cell lines., our data suggest that p65/c-Jun-mediated DNA looping is involved in TNF-alpha-induced MMP-9 up-regulation and that the recruitment of p300 or HDAC1 to NFkappaB and AP-1 binding sites modifies the level of DNA looping., MMP-9/RECK imbalance in cervical smears is significantly associated with high-grade cervical diseases and infection by alpha-9 HPV and C. trachomatis., Curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cells through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways., CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2 expression., Reduction of MMP-9 (via siRNA knockdown, and in MMP-9 KO mice) resulted in decreased Respiratory Syncytial Virus replication., elevated cMMP-9 concentration was associated with more severe characteristics of adenomas, we summarize the cycle of MMP-9 effects on cytokine production and cleavage to regulate leukocyte functions. Although we use MI as the example process, similar events occur in other inflammatory and wound healing conditions., Findings suggested that MMP-9 and MMP-2 overexpression might indicate a higher risk of poor prognosis in breast cancer. [meta-analysis], Studies indicate that when neutrophil gelatinase-associated lipocalin (NGAL) forms a complex with matrix metalloproteinase-9 (MMP-9) it increases its stability which is important in cancer metastasis., It is likely that the aberrantly accelerated MMP-9 proteolysis during neurogenesis is a biochemical rational for the functional inactivation in Nav1.7, Data suggest that MMP9 expression in white blood cells of subjects with chronic obstructive pulmonary disease (COPD) is up-regulated as compared to non-smoking/smoking control subjects; MMP9 may serve as biomarker for progression/severity of COPD., plasma MMP-9 levels are higher in patients that have endoleaks 3 months after EVAR compared to patients that have successful exclusion of their aneurysm [meta-analysis], Relationships between polymorphisms in the MMP-9 gene and chronic obstructive respiratory disease susceptibility., Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications., MMP-9 is positively correlated with common carotid artery intima media thickness both in stroke patients and asymptomatic subjects, ADAM15 promotes lung cancer cell invasion through directly targeting MMP9 activation., plasma MMP-9 levels before vaccination might be potentially useful as a biomarker for selecting advanced cancer patients who would benefit from personalized peptide vaccination., MMP-9 C(-1562)T polymorphism is significantly associated with risk of stroke in patients with and without T2DM., Report MMP9 expression in giant cell tumor of bones., Coexpression of KGF and MMP-9 in gastric cancer could be a useful prognostic factor, and MMP-9 might also serve as a novel target for both prognostic prediction and therapeutics., At baseline, NGAL-MMP-9 levels were significantly higher in active Crohn's disease (CD) patients vs healthy controls. After treatment, NGAL-MMP-9 levels significantly decreased in completely healed CD patients., knockdown of EpCAM can inhibition breast cancer cell growth and metastasis via inhibition of the Ras/Raf/ERK signaling pathway and MMP-9, MTBRa activates TLR2/ERK signalings to induce TNF-alpha and elicit MMP-1 and MMP-9 in human PMCs, which are associated with effusion volume and pleural fibrosis and may contribute to pathogenesis of TBP., Data show that higher plasma levels of matrixmetalloproteinases 2/9 (MMP-2/MMP-9), osteopontin (OPN) and interleukin-6 (IL-6) were observed in Non-Hodgkin lymphomas (NHL) patients compared to controls., Levels of plasma MMP-9 are independently associated with risk of first-time Coronary Heart Disease events, regardless of adjustments., These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK/JNK-mediated MMP-9 expression, TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of sepsis-associated acute kidney injury, To investigate the relationship between matrix metalloproteinase 9 (MMP-9) gene polymorphism and the efficacy of glucocorticoid therapy in idiopathic pulmonary fibrosis (IPF) patients, Study found that PLGF and MMP9 levels both significantly increased in the non-small cell lung cancer (NSCLC) specimens and were strongly correlated. PLGF regulated MMP9 in NSCLC cells, but not vice versa., MMP-9 expression was significantly increased in the dysplastic and neoplastic cases than in nondysplastic cases in ulcerative colitis., The MMP-9 expression in intratumoral stromal cells is associated with the clinicopathologic aggressiveness of lung cancer and is predominantly identified in tumors arising in emphysematous lungs., The preliminary results of this study revealed that MMP-9 may have a role in patients with drug resistant temporal lobe epilepsy with hippocampal sclerosis, MMP1 high expression correlates with Colorectal Liver Metastasis., Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity., Intensive vascular networks formed by HUVECs were associated with hAMSCs or BMMSCs and related to MMP2 and MMP9., rutin is a potential protective agent in spinal cord injury enhancing the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt., Fibroblast MMP9 secretion is induced by Epidermophyton floccosum infection., Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR/NF-small ka, CyrillicB/AP-1 signaling pathways in human endothelial cells., The expression levels of matrix metalloproteinase 9 significantly decreased at 50 microM (P<0.05). Further, it suppressed cell motility by downregulating the expression of matrix metalloproteinase., MDA and MMP-9 are mediators of chronic kidney disease-related vascular remodeling in Cardiometabolic Syndrome, Data show that evodiamine significantly decreased mRNA and protein levels of matrix metallopeptidase 2 (MMP-2) in the nasopharyngeal carcinoma (NPC) cells, but had little effects on matrix metallopeptidase 9 (MMP-9) mRNA and protein levels., data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB-dependent upregulation of MMP-9 and MMP-2, VEGFR-1 activation-induced MMP-9-dependent invasion in hepatocellular carcinoma, Data show that the serum matrix metalloproteinase-9 (MMP-9) levels in psoriasis were significantly higher than that in controls, but there was not any association of MMP-9 polymorphisms with susceptibility to psoriasis vulgaris., Studied the acute effects of exercise on Metalloproteinase-9, adhesion molecules, angiogenic factors, and CACs in early MetS., In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation., the serum levels of MMP-2 and MMP-9 proteins were higher in patients with OA than in controls, while MMP-1 and MMP-9 protein expressions were higher in the synovial joint fluid of patients with osteoarthritis than in controls., may be mediated by Flt3L- and MMP-9-dependent mobilization of dendritic cells, Results show that TSG101 bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression in different cell types., our study suggests that MMP9 rs3918242 polymorphism is correlated with an elevated risk of ischemic stroke., The single nucleotide polymorphism at position -1562C/T of MMP9 results in the modulation for binding of transcription factors to the MMP9 gene promoter and thereby causes differences in protein expression and enzymatic activity., It demonstrated that MMP-9 to TIMP-1 ratio was positively associated with body weight and waist circumference 3 years after a 12-week low-calorie-diet weight-reduction program in men with metabolic syndrome., This study showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of cardiovascular diseases (CVDs) suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs., targeting EGFR signaling and its downstream molecules contributed to the inhibition of EGFinduced HT29 cell metastasis caused by tetrandrine, eventually leading to a reduction in the mRNA and gelatinase activities of MMP-2 and MMP-9, The blocking of either intracellular ROS or ERK pathway caused the downregulation of MMP-9 and MMP-2 expression., Co-expression of Matrix metalloproteinase-9 and Tenascin-C was associated with poorer prognosis and was found to be an independent predictor of survival, MMP-9 measurement in drainage fluid is not relevant in the detection of anastomotic leakage in patients with colorectal resection., The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9., These results show that increased MMP-8 and decreased TIMP-1 expressions are closely related to the invasive pituitary adenoma, and can be helpful for the evaluation., increasing MMP-9 level was an independent risk factor for hematoma expansion-in-acute hypertensive cerebral hemorrhage., MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes, Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells., Data show that estrogen mediates control of hepatitis C virus through the G-protein-coupled estrogen receptor 30 (GPR30) pathway leading to cleavage of occludin by Matrix Metalloproteinase-9 (MMP-9)., Increased circulating MMP-9 activity is associated with resistant albuminuria and a deleterious oxidative stress environment appears to be the underlying mechanism., MMP-9 -1562C/T polymorphism was not associated with preeclampsia risk (Meta-Analysis), Knockdown of Piwil2 gene in SiHa cells inhibited cell growth and invasion, and downregulated matrix metalloproteinase-9 (MMP-9) compared to scrambled shRNA transfected cells, Overall, these results suggest that PrP(c) contribute the breast cancer invasion and migration via MMP-9., MMP9 rs3918242 polymorphism is associated with an elevated risk of ischemic stroke and that this gene polymorphism interacts with BMI in the risk of ischemic stroke., Overexpression of MMP9 in both NPC tissue and blood sample might serve as an indicator of prognosis in NPC patients., Monocytes increase myofibroblast ECM remodeling through increased MMP9 release., In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment., modest association of MMP-9 rs17576 AA genotype with Parkinson disease susceptibility in the Taiwan population, Data show that levels of 82kDa-proMMP-9-(matrix metalloproteinase (MMP)-9) positive blasts were associated with a better clinical outcome., The MMP9 (A8208G) as well as TIMP1 (C5367) genetic polymorphisms are not associated with calcific aortic stenosis., TIMP3 was validated as a direct target of miRNA-21 by dual-luciferase reporter assay. Silencing with small interfering RNA against TIMP3 promoted angiogenesis and increased MMP2 and MMP9 expression at the protein level., dual-luciferase reporter assay showed that MMP-9 as a target of miR-183, Mast cell density and expression of MMP-9, RANKL and Ntx correlated positively with of bone disease severity in multiple myeloma patients., Our results revealed that oxLDL was dynamically associated with autophagy and 100 mug/ml oxLDL blocked autophagic flux in THP-1 cells., Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas., High MMP9 expression is associated with colorectal cancer., Cerebrospinal GDF15, but not MMP9, may be a potential marker of Lewy body disorders., determined normal concentration ranges for MMP-1, MMP-2, MMP-9, TIMP-1, and ratios of concentrations of MMPs and TIMP-1 (MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-9/TIMP-1) in the amniotic fluid at the first period of labor in physiological pregnancy., The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 and MMP-9 and in some cases the enhanced activity of uPA and ACE, which makes an additional contribution to the increased invasive potential of tumor, Patients with primary Glioblastoma multiform with low MMP9 expression may have longer survival and may benefit from temozolomide chemotherapy., Cross-talk between macrophages and smooth muscle cells impairs collagen synthesis and MMP1/9 activity, promoting angiogenesis., Data show that spider venom sphingomyelinase D increased expression/secretion of MMP2, MMP9 and MMP7 which was associated with keratinocyte cell death., Low MMP9 expression is associated with Sepsis., MMP9 and PIWIL2 expression levels in cancerous tissues were significantly higher than the adjacent normal tissues,
OFFICIAL_GENE_SYMBOL MMP9,
OMIM_DISEASE Metaphyseal anadysplasia 2,
SP_COMMENT catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 3 calcium ions per subunit., disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5)., function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide., induction:Activated by 4-aminophenylmercuric acetate and phorbol ester., miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status., PTM:N- and O-glycosylated., PTM:Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9., similarity:Belongs to the peptidase M10A family., similarity:Contains 3 fibronectin type-II domains., similarity:Contains 4 hemopexin-like domains., subunit:Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form., tissue specificity:Produced by normal alveolar macrophages and granulocytes.,