Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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matrix metallopeptidase 2(MMP2) matrix metallopeptidase 2(MMP2) Related Genes Homo sapiens
CHROMOSOME 16,
CYTOBAND 16q13-q21,
ENSEMBL_GENE_ID ENSG00000087245,
GENERIF_SUMMARY involvement of MMPs in microinvasive carcinomas, non-steroidal anti-inflammatory drugs suppress MMP-2 expression via repression of transcription, Activated matrix metalloproteinase-2--a potential marker of prognosis for epithelial ovarian cancer., results indicate that two kinds of pro-form and active-form matrix metalloproteinases, MMP-2 and MMP-9, and their degradation products, are present in human seminal plasma, 17beta-estradiol had no influence on production in MG-63 cells or human osteoblast cultures, Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts., design, synthesis and characterization of potent slow-binding inhibitors, repression of expression by ATF3, in differentiating trophoblasts Nitric Oxide regulates the induction of MMP-2 and MMP-9 required for invasion during embryo implantation, shed as membrane vesicle associated components by endothelial cells and this may be a mechanism for regulating focalized proteolytic activity vital to invasive and morphogenic events during angiogenesis, Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas, in pancreatic cancer, invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion., MMP-2 expression seemed to have an important role to play in the epithelial differentiation of tumour cells in synovial sarcoma., SB203580, a p38 MAP kinase inhibitor, reduces MMP-2 expression in melanoma cell line MeWO., increasing expression and endometrial carcinoma appear closely related, A study of the col-1 module of MMP2; structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains., Levels of MMP2 mRNA were reduced in two neuroblastoma clones treated with 300 nM PAF, which was accompanied by an inhibition of invasiveness through Matrigel and by a promotion of differentiation., activation by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species, activation associated with malignant lung cell phenotype; correlation between low hemoglobin level and T/N ratio of MMP-2 may indicate indicate significance of MMP-2 for angiogenesis, Significantly increased activity of MMP-2 was recognized in tumors showing tenascin-C degradation., expression level of MMP-2 mRNA may regulate with invasion ability of cervical cancer, Increased gelatinase activity in Systemic Sclerosis fibroblasts seems to be regulated at translational and/or post-translational level., Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients., destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells., N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells, MMP2 inhibition by NSAIDs via suppression of the ERK/Sp1-mediated transcription., Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism., Coexpression of glucose transporter 1 and matrix metalloproteinase-2 in human cancers, role in A549 cell migration on laminin-10/11, solution structure of a catalytic domain of MMP-2 complexed with a hydroxamic acid inhibitor (SC-74020), determined by three-dimensional heteronuclear NMR spectroscopy, data indicate the involvement of matrix metalloproteinase 2 and matrix metalloproteinase 9 in the cervical ripening process, calcium regulates MMP2 activation in a MT1-MMP-dependent manner in oral squamous cell carcinoma cells, Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2., Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., MMP2 activation is increased by Eph B4 receptor stimulation in human cells, endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women, role of acidic residues in TIMP-2 and TIMP-4 in binding hemopexin C domain, MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD, MMP2 may play a pivotal role in the formation of capillarylike tubular structures in a collagen-containing fibrin matrix in vitro and may be involved in angiogenesis in a fibrinous exudate in vivo., Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates enzyme and cd44 in cox-2-dependent invasion, strong MMP-2 expression correlated with a favorable prognosis of Hodgkin's lymphoma, correlation between expression of MMP-2, TIMP-2 protein and the ratio of MMP-2/TIMP-2 and clinical-pathological parameters of patients with gallbladder carcinoma, The in vitro invasive ability of ovarian tumor cells appeared to be positive correlated to high expression of VEGF and MMP-2., Changes in plasma MMP-2 and TIMP-2 during cardiopulmonary bypass may play an important role in LV remodeling after cardiac surgery., up-regulation of MMP-2 in stromal cells of chronic inflammatory demyelinating polyneuropathy and in vasculitic neuropathies, laminin-5 as a substrate for mTLD, suggesting a role for laminin-5 processing by mTLD in the skin., There are two TIMP binding sites on the hemopexin domain of MMP-2, The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix., Peptide binding results in perturbation of signals from residues located in the gelatin-binding pocket and flexible parts of the molecule., No difference in MMP-2 between RG and SG. Only an increase with time under both conditions., data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein, gelatinase A is inhibited by amyloid precursor protein, specifically in the decapeptide region, matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis, MMP-2 may contribute to eosinophil and mast cell migrations into nasal polyp tissue., Data show that cells grown on oxidized ultra-high molecular weight polyethylene (UHMWPE)discs decreased the release and activity of metalloproteinase 2 (MMP-2) but not MMP-9 compared to cells grown on control and non-oxidized UHMWPE discs., MMP-2 is associated with tumor size, invasiveness and survival in breast cancer., TIMP-2 is significantly increased in cerebrospinal fluid of Alzheimer's and Huntington's disease patients., In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower., MMP2 is regulated by IL-8 in invasive pancreatic cancer, MMP2 is induced by snail protein in squamous cell carcinoma, triple-helical peptides are highly selective substrates for and are hydrolyzed by human MMP2 and MMP9, expression and regulation by intestinal myofibroblasts in inflammatory bowel disease, Gelatinase A is an estrogen-responsive gene and the loss of function polymorphism within an operational estrogen receptor binding site associated with a decrease in genetic fitness underscores the biologic significance of promoter polymorphism analyses., Increased expression of MMP-2 in advanced stage and high grade renal cell carcinoma might be associated with tumor invasion and metastasis, Pathogenic amyloid beta stimulates expression and activation of matrix metalloproteinase-2 (MMP-2); the increase in activation is largely due to increased expression of membrane type-1 (MT1)-MMP. MMP-2 inhibitors increased HCSM cell viability, Exploiting their astrocyte environment, glioma cells activate MMP-2 through the urokinase-type plasminogen activator-plasmin cascade, and this leads to the increased invasiveness of glioma cells in the central nervous system., PR-3 is able to degrade matrigel components and denatured collagen and to directly activate secreted but not membrane-bound pro-MMP-2, Increased in situ mmp-2 activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion, plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by activation of MMP-2, Ultraviolet A downregulates MMP-2 in keratinocytes., The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA, Both active gelatinases were detected in tears of severe corneal ulcer or severe ocular burn cases. The active form of gelatinase expression may be related to the severity of ulceration., differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma, palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours, MMP2 increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells., results suggest that matrix metalloproteinase 2 plays an important role in tumor invasion and metastasis, Increased plasma MMP-2 is associated with colorectal cancer, MMP-2 immunostaining was positive in 4 of 8 cases of invasive carcinoma and stained stromal area around tumor nest. Matrix metalloproteinases are activated in carcinoma in situ and in cervical intraepithelial neoplasia of uterine cervix., findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta, ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from vascular endothelial cells and TNF-alpha mediates the effects of ANG II on MMP-2 release., effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts, Laminin-5 gamma 2 chain and MMP-2 may contribute synergistically to the formation of budding colorectal tumor cells., Increased MMP-2 expression by malignant prostatic epithelia is an independent predictor of decreased prostate cancer disease-free survival., a possible of marker for microangiopathies in children and adolescents with type 1 diabetes., Serum MMP-2 does not relate to the late phase of hepatic ischmeic reperfusion injury after human orthotopic liver transplantation., Tissue from lateral and medial rectus muscles had different levels of expression of TIMP-1 and 2, MMP-2, and BMP-4,which may underlie different characteristics of these extraocular muscles and may influence wound healing after strabismus surgery., one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity., the methionine residue and the Met-turn of MMP2 play an essential role in catalysis or active site structure, data supports a role for MMP-2 in breast cancer progression, both in the growth of primary tumors and in their spread to distant organs, Stromal MMP-2 occurs early and may play a role early in ovarian adenocarcinoma invasion., matrix metalloproteinase-2 has a role in progression of breast carcinoma, MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates, Various growth factors induce migration of human non-small cell lung cancer cells in the presence of extracellular matrix (ECM) components MMP-2 and MMP-9., MMP-2, TIMP-1 and TIMP-2 are downregulated in human orthotopic liver transplantation, downregulated by Cytomegalovirus IL-10 activity in uterine microvascular endothelial cells and differentiating-invading cytotrophoblasts, Matrix metalloproteinase-2 may play a role in the pathogenesis, invasion, and metastasis of cutaneous squamous cell carcinoma., Analysis of promoter MMP-2 gene variability could help us to understand individual susceptibility to MMP inhibitor treatment of the coronary artery disease., In control myometrium only 10% of Gelatinase A (MMP-2)exists in an active form, whereas in uterine leiomyomas, especially in large ones, the values reach 30%, elastin derived peptides following interactions with S-Gal elastin receptor can favor melanoma cells invasion through a three-dimensional type I collagen matrix by upregulating MMP-2 activation., MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential., matrix metalloproteinase 2(MMP-2) was uterine smooth muscle tumor of uncertain malignant potential(STUMP), and in 48% of leiomyosarcoma, MMP-2 correlated negatively with fractional shortening & positively with LV dimension. Changes in the release & activity of MMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with hypertrophic cardiomyopathy., MMP-2 or MMP-9 mediated tumor cell invasion requires integrin cytoplasmic-tail motif EKQKVDLSTDC, although there is a seemingly high structural similarity between TACE and MMP-2, these enzymes are significantly diverse in the electronic and chemical properties within their active sites, Helicobacter pylori infection results in substantially increased in the gastric mucosa, probably contributed to in large part by tissue-resident macrophages, Active involvement of MMP-2 and -9 in end-stage liver disease and orthotopic liver transplantation., results suggest that matrix metalloproteinase-9 and matrix metalloproteinase-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling, Activated protein C (APC) and MMP-2 are coordinately up-regulated and tightly bound in rheumatoid arthritis (RA) synovial fluid and colocalized in synovia. APC may modulate MMP-2 activity in RA., marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women, EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck, endothelial cell-associated cathepsins B and L are not involved in the invasive growth of capillaries from existing blood vessels and the presence of collagen is necessary for MMP2 expression in endothelial cells, a mechanism for ROS function in Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell MMP2 and MMP9 during VCAM-1-dependent lymphocyte migration, Streptococcus pyogenes SpeB activates proMMP-2 with subsequent release of proapoptotic TNF-alpha and sFasL leading to apoptosis, tissue damage and streptococcal invasion in the host., MMP-2 plays a pivotal role in oxLDL-induced activation of the sphingomyelin/ceramide signaling pathway and subsequent smooth muscle cell proliferation., matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 processing and transport in cultured human vascular smooth muscle cells is regulated by serum fetuin, Identified,in the promoter region of the human MMP-2 gene, a cAMP responsive element binding protein (CREB) consensus domain that is highly responsive to IL-10-dependent down-regulation or MMP2 expression in a primary human prostate tumor cells., biochemical analysis of in-tandem fibronectin type II repeats from human matrix metalloproteinase 2, Brg-1 plays a role in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter., data suggest that the MMP-2/TIMP2 system and an activated extrinsic coagulation pathway could cooperate in conditions of elevated SOX and could influence arterial remodeling resulting in the presence of CVD in haemodialysis patients, Overexpression of MMP-2 is associated with non-small cell lung cancer, the hemopexin domain of MT1-MMP is not required for the activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen, Increased gelatinase in culture medium of toxic epidermal necrolysis or Stevens-Johnson syndrome skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for detachment of epidermis in these diseases., MMP-2 status in stromal fibroblasts, not in tumor cells, was a significant prognostic factor associated with angiogenesis in NSCLC., MMP-2 -1306 C-->T polymorphism may be associated with colorectal cancer development and invasion, clearance of pro-matrix metalloproteinase (MMP)-2.tissue inhibitor of MMPs (TIMP-2) complex involves binding to the cell membrane and subsequent low density lipoprotein receptor-related protein (LRP)-dependent internalization and degradation, The Matrix Metalloproteinase-2 was expressed of cultured human uveal melanocytes, and analysis revealed the Matrix Metalloproteinase-2 mRNA., The expression of MMP-2,MMP-9, TIMP-1 and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones., MMP-2 plays an essential role in tumor invasion and metastasis, while TIMP-2 is shown to strongly inhibit cancer invasion and metastasis., Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2, In melanoma cells microtubule-dependent traffic of MMP2/MMP9-containing vesicles and exocytosis are critical steps for invasive behavior., breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes., secreted pro-MMP-2 and pro-MMP-9 are downregulated by farnesyltransferase inhibitors in carcinoma cells, alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix, This study found an up-regulation of TIMP-1, TIMP-2 and MMP-2 RNA in Duchenne Muscular Dystrophy muscle., The correlation between macrophage infiltration and MMP-II supports the role of macrophages in the development of chronic allograft nephropathy., Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression, furin can directly cleave the RXXR amino acid sequence in the propeptide domain of proMMP-2 leading to inactivation of the enzyme., These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2, which is an important proteolytic factor in lung remodeling., MMP-2 is an important determinant of cancer cell behavior but is not inhibited by the collagen binding segment of fibronectin., MMP2 may have a role in cervical cancer recurrence, Hypoxia increased pro-MMP-2 expression, on collagen type I or type IV further via Erk1/2 and p38 MAP kinase signaling for lung fibroblasts, Inactivating mutations in MMP-2 cause Winchester syndrome, a multicentric osteolysis syndrome., up-regulation of Ang2, MMP-2, MT1-MMP, and LN 5 gamma 2 is associated with the invasiveness displayed by human gliomas, High MMP2 expression is associated with breast cancer, E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2, Hypoxia induces an increased invasive capacity via gelatinase up-regulation without loss of cell viability in adenocarcinomas, Age-related MMP-2 upregulation occurs in the human aorta but not in the internal mammary artery., MMP-2 is required for the mitogenic and proinvasive effects of reactive oxygen species on hepatic stellate cells and demonstrate that ERK1/2 and PI3K are the main signals involved MMP-2 expression., expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes., Lysophosphatidic acid and sphingosine 1-phoshpate enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line., Migration of CD4+ T cells is dependent on MMP2 expression; T-helper type 1 (Th1) cells secrete higher levels of MMP2 and have higher migratory capacity in comparison to Th2 cells., expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells, furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque, MMP-2 may play an important role in the development of invasion and metastasis of gastric cancer., COX-2 and MMP-2 may be involved in the airway inflammatory process and contribute to airway remodeling in COPD., MMP-2 was significantly higher in cell extracts from pseudoxanthoma elasticum patients than in control cells, whereas differences were negligible in the culture media., HIV-1 interaction with mannose receptor induces promotion of MMP-2 through mannose receptor-mediated intracellular signaling in astrocytes., Leptin induced human oarticc smooth muscle cell proliferation and MMP-2 expression through a PKC-dependent activation of NAD(P)H oxidase, MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing in giant cell arteritis, melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients., polymorphisms in the gene promoter do not contribute significantly to the interindividual periodontitis susceptibility, hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues; possible role of hemoglobin in joint damage after intra-articular bleeding, generation and modulation of MMP-2 may be directly involved in the different responses seen in knee ligament injuries, MMP-2 seems to be associated with the chronic progressive phase of the multiple sclerosise., The most invasive cell line secreted the highest amounts of MMP-2 and MMP-9., MMP2 immunoreactivity was present in polymyositis and dermatomyositis, There was a significant correlation between active MMP-2 and the invasion and metastasis of epithelial ovarian cancer. Active MMP-2 is a prognostic indicator in patients with epithelial ovarian cancer., MMP-2 may play an important role in the invasion and metastasis of oral squamous cell carcinoma., Pro-MMP-2 levels were higher at early stages of the degenerative disc disease, Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts, The expression of MMP2 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain., monocyte and macrophaage cells in the breast tumor microenvironment play an important role in the modulation of MMP-2., AP-1 Decoy inhibits the increase in MMP-2 activity and the up-regulation of TIMP-1 induced by bleomycin-A5 in pulmonary fibroblasts., MMP-2 may be a marker of microangiopathy, Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-2 is expressed in all of the cysts, FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase, PAF stimulated the gelatinase activity of MMP-2 by activating transcription and MMP-2 expression, MMP-2/-9 activity correlated positively with cardiomyocyte apoptosis. MMPs have pivotal roles in acute cardiac dysfunction during early multiple organ failure in combined vasoconstrictor-masked hypovolemic and endotoxemia shock., Results suggest that MMP-2 might contribute in the pathogenesis of chronic kidney disease., Obese women with polycystic ovary syndrome have elevated serum concentrations of MMP-2., variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity, These findings strongly indicate that increased MMP-2 expression in uterosacral ligaments is associated with pelvic organ prolapse., Active MMP-2 levels are constant during the menstrual cycle., ATP induced phosphorylation of intracellular JNK, and inhibition of the JNK pathway blocked ATP-stimulated MMP-2 release, indicating signaling via this pathway., MMP2 activity in human endothelial cells exposed to high glucose is inhibited by acetylsalicylic acid, These results suggest the activation of proMMP-2 as an important event in the process of uveal melanoma progression., Both MAPKAPK2 and HSP27 are necessary for TGFbeta-mediated increases in MMP-2 and cell invasion in human prostate cancer., MMP-9 and MMP-2 are mediators of inflammation in chronic otitis media with effusion, TGF-beta1 increases in vitro airway wound repair via MMP-2 upregulationin respiratory epithelial wound repair., Results of this study provide evidence that MMP-2 immunoreactive protein is prognostic in estimation of the aggressive clinical course of head and neck squamous cell carcinoma., The colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity., results strongly suggest that Src induces MMP-2 expression via transcription activation and the ERK/Sp1 signaling pathway is involved in this process, variations in the MMP2 gene do not contribute to the development of abdominal aortic aneurysm, MMP-2 expression was increased in posterior wall of thoracic aortic aneurysms., association between oxidative stress and the MMPs/TIMPs system in hemodialysis patients could represent one of the mechanisms involved in the progression of atherosclerosis in this population, PDK1 mediates mammary epithelial cell growth and invasion in part by MT1-MMP induction, which in turn activates MMP-2 and modulates the ECM proteins decorin and collagen, p16 attenuates Sp1 binding to the MMP-2 promoter to suppress gene transcription and overexpression of Sp1 may counteract p16-induced downregulation of MMP-2., potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-2 was reduced in women with menorrhagia, Higher MMP2 activity is associated with breast cancer, chitooligosaccharides may play an important role in the prevention and treatment of MMP-2 mediated several health problems such as metastasis and wrinkle formation, Basal secretion levels of active matrix metalloproteinase-2 respond to various extracellular matrix proteins, cytokines, and growth factors in normal human melanocyte cells and melanoma cell lines from different stages of neoplastic progression., MMP-2 expression has significant correlation with tumor invasion, tumor differentiation and lymph node metastases; MMP-2 may participate in the development of lymph node micrometastasis of gastric carcinoma, Up-regulation of MMP-2 expression was observed in atypical and anaplastic meningiomas., an imbalance between the MMP-2 and TIMP-2, caused primarily by an increase in TIMP-2 activity, contributes to the pathogenesis of diabetic nephropathy., Increase in serum levels eight days after IVIG treatment in neuromuscular disease., When all three proteases are studied in combination, a tendency was found for tumors with high MMP-2, high MMP-14 and low TIMP-2 expression to predict a poor prognosis but the results did not reach significance, In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated., MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors., These results indicate a temporal relationship between MMP-2 production by endothelial cells and the onset of angiogenic event., plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism, overexpression of matrix metallopeptidase 2 and mutant p53 is associated with hydatidiform mole, Two androgen response elements are shown to be responsesible for androgen-induced MMP-2 expression in prostate cancer cells., Inhibition of MMP-2 in transgenic mice may offer an additional approach for treatment of chronic kidney diseases., Results demonstrated higher expression of MMP-2 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences., gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation, Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis., All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II., A pathogenic role for MMP-2 is sugggested for MMP-2 in the alteration of the extracellular matrix of cerebral arteries during aneurysm formation., TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis., Valproic acid causes a change in acetylation of this gene., Data show that MMP2 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family., No convincing evidence was found to support the association of MMP2 SNPs with increased breast cancer risk or survival., Astrocytes surrounding amyloid plaques show enhanced expression of MMP-2 in aged amyloid precursor protein (APP)/presenilin 1 transgenic mice., The expression of MMP-2 and MT1-MMP in atrophic oral lichen planus was significantly higher than in non-atrophic OLP., The effects of turbinatocoumarin and several chalcones from D. turbinata on MMP2 secretion by U87 tumor cells is reported., MMP2 was mainly localized in a concentric layer of the ovarian stroma., novel mode of proMMP-2 activation mediated by serglycin-dependent mast cells serine proteases, This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression., MMP-2 action negatively affects the neutrophils' migration across type IV coated membranes., We conclude that ischemic colitis induces increased activity and expression of MMP-9 and MMP-2 in the involved colonic mucosa., The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1-dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke-related emphysema., High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases., nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins, identifies Src and MMP-2 as potential therapeutic targets in human herpesvirus 8 associated Kaposi Sarcoma and idiopathic pulmonary arterial hypertension, in vitro findings suggest that the environment within the airways of patients with asthma enhances MMP-2 and -14 protein and activity by a complex interaction of transcriptional and posttranscriptional mechanisms, which may contribute to ASM migration., beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed, Results describe the opposite effects of high glucose on matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human endothelial cells., Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis., the -735C/T MMP-2 polymorphism might be an independent prognostic marker in non-small cell lung cancers, Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis., The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells., Parotid saliva of infantile chronic recurrent parotitis patients showed an increased protein concentration, altered mode of protein diffusion, Infliximab treatment increases MMP-2 in serum of patients with CD, the latter also in the intestine, which extends and confirms our previous ex vivo explants observations., This study demonstrates that ATF2 mediates the TGF-beta-induced MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-beta., Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c., MMP2 may have a possible role in the determination of arterial function; has potential implications for involvement in the pathophysiology of cardiovascular diseases., The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported., Upregulation of matrix metalloproteinase-2 (MMP-2) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees., LPA had no effects on membrane type 1-MMP or tissue inhibitor of metalloproteinase-2 expression, but up-regulated MMP-2 levels, contributing to the induction of MMP-2 activation., Plasma levels are increaed diabetic patients which may reflect abnormal extracellular matrix metabolism., Elevated activities of MMP-2 in the non-tumorous lung tissues of curatively resected stage I NSCLC patients are associated with tumor recurrence, We conclude that induction of MMP1 participates in cell invasion and also plays an important role in HIF-1alpha-induced activation of MMP2., mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics. Positive correlation was found between hepatosplenomegaly and the MMP-2/TIMP-1 and MMP-2/TIMP-2 ratios and between CNS involvement and the MMP-2/TIMP-2 ratio, MMP-2 probably plays an important role in the carcinogenesis and progression of laryngeal squamous cell carcinoma., No significant variation in MMP2 was present in the diabetic group or in patients with acute coronary disease syndrome., We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite., The results indicate that TIMP-2 and MMP-2, Epithelial MMP-2 expression is associated with pancreatic cancer, may degrade fibrillin-2 and may play a role in the remodeling of elastic system fibers in the periodontal ligament, Results showed that the endogenous matrix metalloproteinase-2 might be involved in skin development and in maintenance of cutaneous structure and function., epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis, MMP-2 is modulated by phosphorylation on multiple sites in a tumor cell line and protein kinase C may be a regulator of this protease in vivo., Expression of active MMP-2 was increased in 9L/F344 rat brain during the growth of malignant gliomas at different time intervals, which indicate that 9L/F344 animal model may be a prospective animal model to test new MMPs inhibitors., gene polymorphisms for MMP-2 did not show any association with the G-AgP in Chinese subjects with generalized aggressive periodontitis, AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP2., Transendothelial migration of mesenchymal stem cells is at least partially regulated by MMP-2., Activated MMP-2 and MMP-9 were detected in eight out of nine cases of floppy valves., Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response., These experiments identified a collagen-binding domain (CBD)-binding site on type I collagen and demonstrated that a corresponding synthetic peptide can inhibit hydrolysis of type I and IV collagens by competing CBD-mediated gelatin binding to MMP-2., proMMP-2 and proMMP-9 secretion are decreased in THP-1 cells infected with Toxoplasma gondii, Bcl-2 induces the expression of MMP2 in renal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro., stromal fibroblasts play a role in promoting pancreatic cancer metastasis via activation of the uPA-plasminogen-MMP-2 cascade, Our results suggest that the presence of -1575G allele in the MMP-2 promoter region may be of significance in the assessment of colorectal cancer risk and invasive potential., describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes, Matrix metalloproteinase 2 gene analysis was negative for mutation in the three patients., Expression of MMP2 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissie., results suggest that MMP2 is a more sensitive predictor than MMP9 of lung cancer progression, metastasis, and survival, positive correlation between the expressions of CD147, MMP-2 in human gliomas and the degree of malignancy and prognosis, genetic polymorphisms or haplotype in the MMP2 promoter may play a role in mediating the susceptibility to nasopharyngeal carcinoma in Chinese populations, MMP-2 activity was enhanced in pleural effusions from patients with benign diseases compared with cancer patients., Results determine the level of MMP-2, its natural inhibitor TIMP-2, their ratio and HER-2/neu as diagnostic and prognostic factors in breast cancer., Binding of two zinc and two calcium ions to the MMP-2 catalytic domain is energetically favored., syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis, COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness., MMP-2 expression in surface epithelium basal cells of vocal fold polyps showed enhancement compared with normal vocal folds., ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer, MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow., Arsenic trioxide may down-regulate the expression of VEGF and inhibit the activity of MMP-2 and 9., The data provide evidence supporting a potential role for the endothelial production of MMPs in promoting cancer cell extravasation., TIMP-1 and its inhibitory domain, N-TIMP-1, are weak inhibitors of MMP2., 6Mercaptopurine decreased HSP27 nucleous expression that was associated with inhibited MMP2 activity and NO production., NGF stimulates endothelial cell invasion and cord formation by augmenting MMP-2 via the PI3K/Akt signaling pathway and AP-2 transcription factor, which may be responsible for triggering angiogenesis., VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women, These findings suggest that MMP-2 -1306C/T polymorphism may be a genetic risk factor related to lumbar disc disease susceptibility in the young adult population., fibroblast growth factor 2 release from the lens capsule by MMP-2 is essential to lens epithelial cell viability and survival, P-gp substrate drugs can greatly upregulate the expression of CD147 and MMP2 and 9 in multidrug resistant breast cancer cells, therefore enhancing the tumor metastatic capability., MMP-9, but not TIMP-1 nor MMP-2 expression is increased in plaques causing acute coronary syndrome., MMPs also cleave a variety of non-ECM proteins, including cytokines, chemokines, and growth factors, activating or inactivating them, or generating other products that have biological consequences., Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of MMP2., Increased mmp-2 is assopciated with squamous cell laryngeal carcinoma, an interaction between chitosan and matrix metalloprotease 2 decreases the invasive activity of human melanoma cells, The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC, ROCK-II is a critical mediator of colon cancer cell invasion through its modulation of MMP-2 and -13 at the site of invadopodia but regulates proliferation in non-malignant intestinal cells., Nicorandil suppresses the increases in MMP2 and MMP9 levels and activities and prevents the development of ventricular remodeling in acute myocardial infarct, MMP-2, MT1-MMP and TIMP-2 mRNA expression levels were correlated with clinical stages and histological subtypes of thymic epithelial tumours. The activation of pro-MMP-2 might be mediated by MT1-MMP and TIMP-2 up-regulation., direct CpG-oligodeoxynucleotides and TLR-9 interactions in HT-29 cells could provide new approaches in malignant tumor therapeutic strategies, MMP-2 processing of HARP and CTGF released vascular endothelial growth factor (VEGF) from angiogenic inhibitory complexes., SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level., MMP-2 may be implicated in pathogenesis of leiomyoma., serum MMP-2 levels in Behcets patients with vascular involvement showed a positive correlation between Leeds activity score, Mmp2 and Mmp9 gelatinase activity, and caspase3 immunoreactivity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice., This study does not provide strong evidence for further investigation into the role of the MMP2 and MMP3 variants in melanoma progression, MMP2 expression varied with histological type in epithelial ovarian cancers. It was associated with better prognosis. In stromal cells, its expression was correlated with hyaluronan expression., The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma, MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2, One single irradiation of UVB increases the immunohistochemical expression of gelatinases in almost all evaluated cell lines, with the exception of MMP-9 in keratinocytes, MMP-2 upregulation confers on tumor cells the ability to degrade the subepithelial basement membrane and subsequently invade the cervix., Patients with larger aortic diameters have increased MMP-2/TIMP-1. Modifying MMP expression may have a role in development of aneurysms., exposure of human melanoma cells to hyaluronan fragments leads to nuclear factor kB (NFk-B) activation followed by enhanced expression of matrix metalloprotease (MMP) 2 and interleukin (IL)-8, factors that can contribute to melanoma progression., polymorphisms in MMP1, MMP2, MMP3, MMP9, or MMP10 weren't associated with acute MI compared with angina or with coronary disease. Circulating levels of MMP2 are independently associated with development of an acute MI rather than stable angina., EMMPRIN and MMP-2 are the major determinants of malignancy in cancers, N-acetylcysteine prevented LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts., MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression., MMP2, MMP14, and MMP9 might be used as prognostic markers in patients with sinonasal and oral malignant melanoma., These results suggest that P. acnes stimulates hDF to produce TNF-alpha, which mediates the expression of proMMP-2 through the NF-kappaB pathway., 735C/T polymorphism not related to generalized aggressive periodontitis, The expression of MMP-2 in supraglottic carcinoma was significantly higher than that in normal laryngeal mucosa., Chorionic gonadotropin promotes trophoblast invasion and migration through activation of ERK and AKT signaling involving their downstream effector MMP-2., The activity of MMP-2 in the patients with positive tenascin-C degradation was also found to be significantly higher than that in the patients without., The aim of this study was to analyse the influence of recombinant IFN beta-1a (identical with natural IFN-beta) on MMP-2 and MMP-9 activities, A high incidence of MMP-2 expression is confirmed in erythroblasts from acute myeloid leukemia (AML) patients and suggests the possible involvement of MMP-2 in the invasive phenotype of AML., platelet activation and aggregation is regulated by MMP-2 that specifically interacts with integrin alpha(IIb)beta(3), Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis., data suggest that MMP-2 -735C/T, MMP-9 -1562C/T and MMP-12 357Asn/Ser polymorphisms are not associated with susceptibility to severe CP in Turkish population. T allele of MMP-9 -1562 gene might be associated with decreased susceptibility to severe CP., Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased MMP2levels., In carotid stenosis MMP-2 levels tended to increase 30 days after carotid endarterectomy., The expression level of Matrix Metalloproteinase 2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes' stage in colon cancer tissues., These findings suggest that MMP2 promoter polymorphisms may provide some predictive value for hepatocellular carcinoma recurrence after liver transplantation., Report association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women., We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription., Markedly increased levels of serum MMP-2 in infectious, especially bacterial, meningitis may reflect the degree of damage to the blood-brain barrier., MMP-2 could be acknowledged as a new prognostic factor in melanoma., IR/visible light spectrum of sunlight significantly decreased skin MMP-2 expression., The MMP2 rs243865-T allele is not a major rheumatoid arthritis genetic factor in this population., These results suggest that MMP-2 overexpression by cancer cells in peritoneal implants and not in the primary ovarian cancer is predictive of ovarian cancer prognosis and more likely reflects the presence of particularly aggressive clones of cancer cells., MMP-2 -1306C-->T polymorphism contributes to the development of squamous cell cervical cancer in the population studied, especially in women who had first coitus at an early age., Data show that enhanced expression of matrix metalloproteinases 2 was detected in colorectal cancer patients with distant metastases., MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B, Performed molecular docking simulations to study binding at the S1' pocket in the apo form of MMP2, and identify, at the molecular level, the structural properties relevant for the designing of specific inhibitor of MMP-2., results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs., High numbers of human skin cancers express MMP2 and several integrin genes., polymorphisms in the MMP2 is associated with the protective effect of helicobacter pylori on esophageal adenocarcinoma risk, Crucial participants in tumour invasion and metastases are matrix metalloproteinases, tissue inhibitor of metalloproteinase inhibitors and cellular adhesion molecules. They play roles in tumour invasion and metastasis in non-small-cell lung carcinomas., MMP-2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer., Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling., These results indicate an association of MMP-2 -1306C/T polymorphism with the risk of adenomyosis, suggesting a potential role in adenomyosis development in North Chinese women., HCG increases the secretion of MMP-2 and -9 in cytotrophoblasts in a dose-dependent manner., The dysregulated MMP2 expression is associated with infertility and early pregnancy loss., Adenoviral-mediated transfer of RNA interference against MMP-2 results in the retention of neurological function and significantly inhibited tumor growth., Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis., MMP-9, but not MMP-2, may have a role in mechanisms for stimulation of cell division and matrix biosynthesis, which cause matrix remodeling in the umbilical cord of preeclamptic newborns, Report the production of vascular endothelial growth factor and MMP-1/2 via protease-activated receptor in human endometrial stromal cells., This study suggests that MMP14 is involved mostly in prostate cancer implantation and that MMP2 and TIMP2 expression by reactive stromal cells might be used as predictors of diease-free survival in T3N0-2M0 Pca., Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer., the activity of MMP-2 in the internal mammary artery is correlated with age, hypertension, diabetes and estimated glomerular filtration rate., Knockdown of MMP-2 did not significantly alter the metastatic potential of the liver cancer cells but lead to a marked inhibition of metastatic foci growth., MMP-2 expressed by metastatic ovarian cancer cells functionally regulates their attachment to peritoneal surfaces, In this study we found the MMP2 rs2287074 A allele may be associated with a lower likelihood of age-related maculopathy in older Caucasian women, particularly those who have never used hormone therapy., MMP-2 is valuable in determining the patients with more aggressive form of non-small cell lung cancer.., Stromal expression of MMP-2 (matrix metalloproteinase-2) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps, Alcohol reduces MMP-2 plasma activity in healthy humans and in isolated vascular smooth muscle cells., The study suggested that the C/C genotype of the C-735T SNP in the promoter region of MMP-2 gene may be a potential risk factor for epithelial ovarian cancer, but the C-1306T SNP may have no association with the risk of epithelial ovarian cancer., in colorectal neoplasms, MMP-2 expression correlates with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlate with venous invasion, Expression of MMP-2 does not distinctly correlate with the proliferation of endothelial cells, but plays a very important role in affecting endothelial cell migration, invasion and angiogenesis., soluble EMMPRIN probably triggers the promotion of cancer invasion in vivo, MMP-2 inhibition induced apoptotic cell death in vitro, and suppressed tumor growth of preestablished U-251 intracranial xenografts in nude mice, These results suggest an important role for MMP-2 and MMP-9 in the induction of T. cruzi-induced acute myocarditis., regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH., key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Berberine induced down-regulation of MMP2 in gastric neoplastic cells in vitro., MMP-2 overproduction is associated with bone marrow stromal cells in multiple myeloma, In prostate adenocarcinoma distant spread is more likely to occur in patients with high levels of VCAM and low levels of MMP-2., Higher net MMP-9 (but not MMP-2) activity in gestational hypertension., Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs, MMP-2 stimulates keratinocyte survival whereas MMP-9 promotes terminal differentiation., High epithelial MMP-2 expression in gastric cancer is associated with poor survival., MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not., The C allele of MMP-2 -1306C/T polymorphism did not modify the risk of developing endometriosis but significantly increase the risk of developing adenomyosis., Neither MMP-2 SNPs nor MMP-9 SNPs revealed significant association with proliferative diabetic retinopathy in single-locus comparisons., Demonstrate an association of the MMP-2 gene with the development of lacunar stroke, and no association of MMP-2 with other stroke subtypes., The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry., Significantly higher expression of MMP-2 in melanoma-associated spongiform scleropathy(MASS), indicating MMP-2 is involved in development of MASS and is produced by scleral fibroblasts under influence of tumor cells and/or tumor-infiltrating macrophages., megsin indirectly links to MMP2 activation via the inhibition of plasmin enzymatic activity, SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3., The expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in a verrucous proliferative leukoplakia sample, was investigated., Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium., The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients., proMMP-2 activation involves MT1-MMP dimerization, PKC inhibitors blocked phagocytosis by retinal pigment epithelial (RPE)cells. Human RPE-cell line showed reduced secretion of MMP-2, although MMP-9 secretion by PKC activation was conserved in both cell types., Data suggest that KiSS-1 suppresses the motility and invasive ability of renal cell carcinoma cells which possess hOT7T175 with either a negative expression or very low expression level of KiSS-1 through, at least in part, the down-regulation of MMP-2., In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9., There was significant correlation between immunohistochemical staining for MMP-2 & clinical condition of medullary thyroid carcinoma patients & correlation between state of apparent cure compared to persistence of MTC after thyroid surgery., Results describe the relationship between protein expression of VEGF-C, MMP-2 and lymph node metastasis in papillary thyroid cancer., Dengue Virus-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection., Plasma levels of MMP-2 and MMP-9 are increased in obese patients which may reflect abnormal extracellular matrix metabolism., Increased MMP-2 expression is associated with differentiated thyroid carcinoma., Pathologic findings demonstrated that the intensity of MMP2 staining in cancerous tissues was associated significantly with histological types, distant metastasis, and Nevin stages of gallbladder carcinomas., MMP2 transcription activity is significantly upregulated along with neuron and glial cell apoptosis following spinal cord injury in transgenic mice., Curcumin can suppress Tca8113 invasion and migration by reducing the activities of MMP-2 and MMP-9., Formation of adenomyosis does not result from altered invasiveness of endometrial stromal cells, but may result in elevation of MMP-2 and TIMP-1., serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in chronic kidney disease patients, Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2., The MMP2 gene does not play a crucial role in conferring risk for nasal polyps in a Taiwanese population., Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear, This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor., a link between RhoA, JNK, c-Jun, and MMP2 activity that is functionally involved in the reduction in osteosarcoma cell invasion by the statin. This suggests a novel strategy targeting RhoA-JNK-c-Jun signaling to reduce osteosarcoma cell tumorigenesis., 3,4,5-trihydroxybenzaldehyde from Geum japonicum has inhibition effect on MMP-2 and MMP-9 activities in smooth muscle cells, The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues., Low circulating levels of ProMMP-2 are associated with bladder cancer., Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM., Our findings suggest an important, previously unrecognized role for MMP-2 during myelination in the peripheral nervous system., MMP-2 activity is associated with treatment failure in childhood acute lymphoblastic leukemia, Estrogen and progeterone upregulate MT1-MMP/MMP-2 and alter cell migration in vascular smooth cells., This study suggest that carriage of the (-1575G/A, -1306C/T) allele may influence the MS disease process through MMP-2 serum level production., Significantly higher matrix metallopeptidase 2 expression is associated with prostate cancer., Level of plasma MMP-9 and MMP-9, increased plasma activity of MMP-2 in women with metabolic syndrome is important because they fit in with an early stage of cardiovascular disease, Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression., COX-2 and MMP-2 expression was increased in nasopharyngeal carcinoma, and was positively correlated with lymph node metastasis., The structural changes in the venous wall in addition to the increased expression of MMP-2, MMP-9 and MMP-13 in venous aneurysms suggests a possible causal role for these MMPs in their pathogenesis., H(2)O(2) induced cell death and fibronectin mRNA expression, but decreased the amount of MMP-2 mRNA., results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2, The data indicates that the decidual microenvironment may exert the key control for trophoblast cell invasion mainly through influencing MMP-2 expression., Serous and mucinous ovarian tumors express different profiles of MMP-2., RECK is cleaved by MMP-2 and MMP-7 and competitively inhibits MMP-7-catalyzed cleavage of fibronectin, uterine decidua possesses protease activity in situ and in vitro and uterine natural killer cells are a major source of MMP-2 and TIMP-2, The positive expression of MMP-2 can be used to estimate the metastatic potential of cervical squamous carcinoma., MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis can be markers of acute rejection after liver transplantation., Platelet-derived microparticles promote prostate tumor invasiveness, at least in part by stimulation of MMP-2 production, Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis, On the basis of linked-function analysis, we demonstrated that collagen binding domain of MMP2 tuned the cleavage of collagen IV by MMP9, presumably by inducing a ligand-linked structural change on the type IV collagen., The role of MMP-2 and the signaling pathway involved in EGF-promoted invasion by human pancreatic cancer cells PANC-1 was investigated., In prostate cancer patients with tumors of a higher stage (pT3), a polymorphic allele in the MMP2 gene was more frequent than in patients with lower tumor stage, metastasis and survival of patients with bladder are mediated, at least in part, by matrix metalloproteinase-2, role in the pathogenesis of inguinal hernia, Porphyromonas gingivalis could induce human gingival fibroblasts to over-express MMP1 and MMP2, and fimA genotypes of Pg may be related to this pathogenicity., The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis., MMP-2 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls., Results describe the levels of matrix metalloproteinases 2 and 9 in human scar tissue., Data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway., Mechanisms other than COX-2 and MMP-2 may contribute to the promotion of angiogenesis in patients with adenomyosis or endometrial polyps, Data show that dominant-negative transforming growth factor beta type II receptor decreases matrix metalloproteinase 2 in hepatic stellate cells, and upregulates SKI-like oncogene, which antagonizes TGF-beta signaling., Expression of MMP-2 in esophageal squamous cell carcinomas was higher than in eophageal epithelium, and higher in the advanced stage; MMP-2 plays an important role in tumor invasion and metastasis of ESCCs., Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion., Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., The proteolytically active matrix-metalloproteinase (MMP)-2 is upregulated and as an early regulator of ovarian cancer metastasis., TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in Renal clear cell carcinoma patients., As(2)O(3) inhibits expressions of COX-2, MMP-2 and MMP-9 in K562 and SGC7901 cells., selective COX-2 inhibition suppresses the invasion activity of OSCC cells via down-regulation of an MMP-2-activating mechanism involving TIMP-2 and production of the MMP-2 protein by an interaction between cancer cells and stromal fibroblasts, Results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas., Activated protein C resulted in MMP-13 activation in cartilage cultures, and it was associated with increased MMP-2 and MMP-9 activity., Enhanced expressions of MMP-2 and -9, VEGF, and increased microvessel density in endometrial hyperplasia may play important roles in the pathogenesis of women with anovulatory dysfunctional uterine bleeding., The RNA interference approach towards MMP-2 may be an effective therapeutic strategy for the clinical management of pancreatic tumors., Results describe the effect of histamine on cell adhesion and expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 in human tumorigenic and non-tumorigenic mammary cell lines., Tiotropium bromide suppressed MMP2 production by cultured lung fibroblasts., Low Levels of MMP-2 due to epigenetic silencing is associated with invasiveness in cancer., Tn-C deposition into the extracellular matrix requires participation of active MMP-2 and stromal fibroblasts, Evaluated MMP-2 and -9, along with their inhibitors TIMP-1 and -2, in pre-eclamptic women compared with normotensive pregnancy and non-pregnant women.Results confirm that MMP-2 and TIMP-1 values are significantly higher in preeclampsia., MMP-2 polymorphisms are associated with systolic heart failure risk in Han Chinese, Tissue transglutaminase-2 and matrix metalloproteinase-2 expression are significantly correlated in vivo, in peritoneal xenografts and in human ovarian tumors., MMPs play an important role in carcinogenesis of biliary cancers, Combined hyperlipidemic patients have increased levels of prothrombotic and microinflammatory parameters and higher levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 than control subjects., MMP-2 rs17859821 A allele was associated with better prognosis of systolic heart failure in the northern Han Chinese population., Statin therapy did not alter serum MMP-2 in patients with abdominal aortic aneurysms., these results suggest that Ang II mediates an increase in MMP 2 activity in macrovascular endothelial cells through signal transduction pathways dependent on PI3K and Src-family tyrosine kinases activation, as well as JNK and FAK phosphorylation., MMP-1 and MMP-2 are major factors involved in the invasion of endometrium into the peritoneum and in vascularization of endometriosis., Obese children and adolescents had higher circulating MMP-8 concentrations, lower plasma TIMP-1 concentrations, and higher MMP-8/TIMP-1 ratios than non obese controls., promoter gene polymorphism is associated with psoriasis, Studies do not support a role for BSP in promoting metastasis through interactions with pro-MMP-2., Our study revealed increased immunoexpression of MMP-2, MMP-9 and TIMP-2 in acute cellular rejection of renal allografts, found increased MMP-2 expression in cells lacking TSC1/TSC2 compared with their respective controls, Progesterone reduces PR and SP4 binding to the MMP-2 promoter, thereby suppressing transcription, These results together indicate that MMP-2 activity can be promoted in keloid fibroblasts between collagen bundles, matrix metalloproteinase-2 expression in stromal cells can be a high-risk indicator for recurrence in patients with stage II colon cancer, Expression of MMP2 in RCC cells was suppressed by Ror2 knockdown, placing Ror2 as a mediator of MMP2 regulation in RCC and a potential regulator of extracellular matrix remodeling., Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2., these findings support a role for MMP-2 genetic variation in breast cancer susceptibility., Key collagen binding site residues in the three fibronectin type II-like modules of MMP-2 have been localized and functionally confirmed by nuclear magnetic resonance mapping., Patients with coronary heart disease showed increased levels of MMP2 and MMP9., MMP2 expression higher in scar tissue than control, The staining intensity score of E-cadherin=3, matrix a metalloproteinase-7<1, and matrix metalloproteinase-9>or=2 can be used as the diagnostic criteria for hepatocellular adenoma, Protein expression levels of lipocalin-2 are upregulated in visceral adipose tissue of obese subjects along with increased activity of matrix metalloproteinase-2 and matrix metalloproteinase-9/ lipocalin-2 complex., LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, curcumin has anti-metastatic potential resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells., The expression of MMP-2 and MMP-9 were closely related with destruction of the ossicular chain in cholesteatoma., The MMP-2 polymorphism was significantly associated with protection against lung cancer., MMP2 -1360C>T and +649C>T variants are not risk factors for abdominal aortic aneurysms., we found no significant differences of CSF, serum or skin concentrations of MMP-2 in amyotrophic lateral sclerosis (ALS) patients as compared to controls, suggesting it is not the link between ALS neuronal degeneration and skin alterations, hypoxia reduces MMP-2 activation and subsequent invasion of human cardiac myofibroblasts by reducing membrane expression of MT1-MMP and may delay healing after myocardial infarction, FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for oral cavity squamous cell carcinoma treatment., MMP2 was found in epidermal and dermal ests of maligant cells and in atypical melanocytes along the hair follicles in lentigo maligna melanoma, indicating its involvement in tumor invasion., High expression of matrix metalloproteinase-2 was less significant for the invasive potential and prognosis of colorectal tumors., Data show there was a significant correlation between the level of TGF-[beta]1 and the levels of MMP-2 and TIMP-2 immunostainings in pancreatic ductal epithelium., The migration of bone marrow (BM) mesenchymal stromal cells was the result of the variable level of MMP/TIMP in response to inflammatory stimuli., Higher active MMP-2 is associated with colorectal cancer., Data show that mortality was significantly associated with adiponectin, resistin, PIIINP, MMP-2, TIMP-1, and serum creatinine., Functional polymorphisms in matrix metalloproteinases might play roles in developing esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high incidence region of North China., High matrix metallopeptidase 2 is associated with breast cancer., Data suggest an involvement of matrix metalloproteinases 2 and 9 in pseudoxanthoma elasticum pathology., Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion., Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin., Factor Xa and thrombin regulate MMP-2 enzymatic activity through its activation and degradation., Plasma Hg concentration is positively associated with both pro-MMP-9/TIMP-1 and pro-MMP-2/TIMP-2., High expression of MMP-2 is associated with malignant and invasive skin squamous cell carcinoma growth., Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease., Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., Up-regulation of MMP-2 and MMP-9 is one of the mechanisms by which Skp2 promotes lung cancer cell invasion., approximate 40% of plasma specimens from healthy individuals had detectable levels of the MMP-2, SNPs in MMP1, MMP2, MMP7 and MMP12 have roles in response to chemotherapy in lung cancer, We report two siblings affected with a novel mutation in matrix metalloproteinase 2 gene and discuss their clinical and radiographic findings., IL-1beta increased MMP-2 activity and transcription of human cardiac fibroblasts via iNOS-NO pathway., Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4., strong correlation between MMP-2 activation and elastic fiber disorganization, stiffness, calcification, and vasomotor dysfunction in the arterial vasculature in dialyzed chronic kidney disease patients, Higher amniotic fluid MMP-2 and TIMP-2 levels are found in women who eventually develop preeclampsia., present study showed that the MMP-2 -1306CC genotype increased the risk of developing acute myocardial infarction, Of MMP-2/TIMP-2/MMP-14 complex, high expression of MMP-2, TIMP-2 & MMP-14 mRNA may contribute to local invasiveness of ameloblastoma; local invasive capacity of ameloblastoma more likely related to high transcription levels of TIMP-2 and MMP-14, These preliminary data demonstrate the expression of metalloproteinase 2 and 9 proteins in the placentas of uncomplicated pregnancies., Data show that ehe expression level of uPA and MMP-2 was not associated with the grade of CIN lesions., The mRNA expression of MMPs and TIMPs was significantly higher in stroma than in epithelium of salivary gland pleomorphic adenomas., up-regulation of Notch1 expression also reduced the migration of Hep-2 cells, which was closely associated with down-regulation of MMP-2 and MMP-9., RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells., WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2., Orthodontic force regulates levels of secreted MMP2 in periodontal ligament fibroblast cultures., Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases., MMP-2 and MMP-3 are directly linked to Abeta in the brain and a dysfunction may influence the processing of Abeta., Immunoexpression of metalloproteinase-2 does not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer., expression of MMP-2 and TIMP-1 was found to be higher in lung cancer patients. Finally, we claim that determination of MMP-9 enzyme levels and expression of MMP-2 and -9 and TIMP-1 can be used as a marker in lung cancer., Expression and activity of MMP-2 was enhanced by the IkappaBalpha siRNA in human ciliary muscle cells through the activation of the NF-kappaB signaling pathway., EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway., in the proliferative phase of hemangioma, MMP-2 may promote over-proliferation of endothelial cells, MMP-2 transcriptional regulation by EGF in invasive trophoblasts is mediated through several transcription factors including p53, AP-2alpha and -gamma, C/EBPepsilon and -lambda and SP-1. p53 mediates both basic and EGF-induced MMP-2 transcription., Estradiol inhibits MMP-2 expression via the ER and the MAPK pathway in rat cardiac fibroblasts and in a human fibroblast cell line, Cleaved high molecular weight kininogen inhibits tube forming capacity of endothelial progenitor cells by suppression of MMP-2 activation., evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR, Increased matrix metalloproteinase 2 expression is associated with soft tissue sarcoma., cytokines and inhibitors have an up- or down-regulatory effect on MMP-2 and MMP-9 expression in lung cancer and malignant mesothelioma, Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation., Data show that P-cadherin overexpression in breast cancer cells with wild-type E-cadherin promotes cell invasion, motility, and induces the secretion of MMP-1 and MMP-2, which then lead to P-cadherin ectodomain cleavage., Findings suggest an important role for MMP-2 in transformation mediated by HMGA1 in large-cell, undifferentiated lung carcinoma and support the development of strategies to target this pathway in selected tumors., de-N-acetyl GM3 activates matrix metalloproteinase-2 in melanoma cell lines, High MMP2 is associated with cutaneous malignant melanoma., results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2., STK15 Phe31Ile and MMP-2 -735C/T polymorphisms might be the genetic susceptibility factors for esophageal cancer in the Mongolian population., ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB, Higher levels of TIMP-2 were found in the gingival crevicular fluid of chronic periodontitis patients compared with controls, and these markers decreased 3 months after periodontal therapy., Low or no RECK expression and increased MMP-2 expression may be associated with negative clinical findings in ameloblastoma, changed level of matrix metalloproteinases, especially that of MMP-2 in serum, may be of value for detection of cardiac involvement in Emery-Dreyfuss muscular dystrophy patients, especially in those patients with no evident subjective cardiac symptoms, a possible relationship between the entity of morphological disorganization of the oral mucosa in different pathologies and the increase of MMP-2 and MMP-9 expression., The expressions of MMP-2 and MMP-9 were positively correlated with CD147 expression in breast cancer., Acute high glucose stimulation down-regulates the expressions of MMP-2 and EMMPRIN at RNA and protein levels in the endothelial cells., Cav1 might regulate MMP2 and MMP9 activity through Erk-activated signal pathway, Galpha12/13 upregulate matrix metalloproteinase-2 via p53 promoting human breast cell invasion., Data demonstrat that two major apoptotic pathways in ECs, caspases and p38 MAPK (p38), differently affect endothelial cell behavior as well as matrix metalloproteinase-2 expression., Data demonstrate that EMMPRIN expression increases in the human left ventricle after acute myocardial infarction (AMI), and that expression of MMP-2 and MMP-9 are correlated with EMMPRIN expression in AMI., Results show that the treatment of THP-1 cells with CRP enhances the expression of MMPs and TIMP-1, 2, and 9 genes significantly, and that this upregulation is attenuated by atorvastatin, Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis., In a large cohort of European Caucasian systemic sclerosis (SSc) patients, MMP2, MMP9, and MMP14 genes are not involved in the genetic background of SSc., Elevated serum activities of MMP-2 and -9 are associated with dramatically increased restenosis rates after PCI with implantation of drug-eluting stents., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9., No relationship was found in Chinese Han patients with hypertensive heart disease between the presence of the MMP-2 -1306C>T and -735C>T polymorphism and atrial fibrillation., HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP-2 promoter., The study shows a novel mechanism for antiproliferative effects of PKD1, a protein of emerging translational interest in several human cancers, through increased production of MMP-2 and MMP-9 in cancer cells., Thrombin enhances the migration of chondrosarcoma cells by increasing MMP-2 and MMP-13 expression through the PAR/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Study confirms an altered MMP2 expression in subjects with chronic C hepatitis and such alterations can contribute to development of liver fibrosis., role of osteopontin (OPN) in prostate cancer PC-3 cells; study demonstrated OPN knockdown could downregulate MMP-2 and MMP-9; IKK-2 may play a crucial role in OPN-induced MMP-2 and MMP-9 expressions via NF-kappaB-mediated signaling pathways, regulates the expression of MMP-2 and MMP-9, which increases the invasion ability of MCF-7 cells through the Ras/MAPK signaling pathway., PTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma. The expression of PTEN and MMP-2 correlates with the malignance and the aggression of thymoma., secretion of MMP-2 proform increased significantly in cells subjected to 4 h of hypoxia followed by 4 or 24 h of reoxygenation., Findings indicate that Twist1 induces HCC invasion via increased activity in MMPs, specifically in MMP2 and MMP9, leading to poor clinical prognoses., Matrix Metalloproteinase-2 gene variants are strongly associated with patient's functional disability at three months after stroke onset., results presented here strongly suggest that MMP-2 interacts with alpha(IIb)beta(3) to regulate the shedding of CD40L exposed on the surfaces of activated human platelets, An impaired MMP2/TIMP2 ratio might be involved in the decreased levels of circulating TRAIL observed after acute myocardial infarct., The substrate degradomes of two closely related matrix metalloproteinases, MMP-2 (gelatinase A) and MMP-9 (gelatinase B), in fibroblast secreted proteins, were compared., Interpretation of differential expression of MMP2 between gastric cancer and normal tissue is difficult to establish., AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis, MMP2 promoter polymorphisms was associated with lower susceptibility to lung cancer, Functional polymorphism in the promoter region of the MMP-2 and MMP-9 genes plays a certain role in the development of acute coronary events., emodin, aloe-emodin and rhein inhibit the protein levels and activities of matrix MMP-2 but not gene expression of MMP-2; they do inhibit gene expression of MMP-9 and migration and invasion of human tongue cancer SCC-4 cells, Matrix metalloproteinase (MMP-9 and MMP-2) gene polymorphisms influence allograft survival in renal transplant recipients., expression of CD147 was positively correlated with matrix metalloproteinase-2, Ki-67 labeling index, or both in invasive pituitary adenomas (P< .01 and P< .01, respectively)., overexpression/downexpression of ZNF580 leads to the enhancement/decrease of MMP2 and VEGF expression as well as the migration and proliferation endothelial cells., Systematic review/meta-analysis suggesting that MMP-2 expression is of poor prognostic significance for survival in patients with non-small cell lung cancer., inhibition of MMP-2 activity (proprotein convertases) activity results in decreased invasiveness of primary human melanoma cells despite their altered p53, CDKN2A and N-Ras genes, Data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway., The four functional SNPs in the MMP1, -2, and -3 promoter regions do not play critical roles in the development of high myopia in the Japanese population, After dsRNA stimulation expression of MMP-2 mRNA did not change in human nasal polyp epithelial cells., Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions., The present article studied the expression of CD147 on neutrophils and its potential role in neutrophil chemotaxis, MMPs production and the invasiveness of fibroblast-like synoviocytes., Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147., Matrix metalloproteinase-2 and -9 contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues., Statistically significant genetic associations of ocular refraction to polymorphisms near MMP1 and within MMP2 were identified in the AMISH but not among the ASHK families., A positive correlation was found between the expressions of HIF-1alpha and MMP-2 in degenerative intervertebral discs., MMP-2 and MMP-9 increased significantly in chronic subdural hematoma as compared with those in subdural effusion., The abnormal expression levels of RECK and MMP-2 may play an important role in carcinogenesis of esophageal squamous carcinoma., Data show that gene expression rates of MMP-2 and TIMP-1 were higher in ONFH biopsies whereas TIMP-2 and MMP-9 gene expression was not significantly altered., MMP-2 activity is decreased in the urine of patients with benign prostate hyperplasia compared to cancer., TGF-beta, leading the tissue invasion mediated by MMP-2, is a strong promoter of tumor progression., The aim of the present study was to determine glomerular immunoexpression of MMP-2 and MMP-9 in IgA nephropathy and Schoenlein-Henoch nephritis., The promoter polymorphisms associated with Pseudoxanthoma elasticum may lead to increased MMP2 expression and thereby contribute to the elevated proteolytic activity observed in PXE, opioids have an effect on matrix metalloproteinase-2 and -9 secretion and mRNA levels in MCF-7 breast cancer cell line, MMP-2 release and activation differentially degrades Abeta species, delaying their toxicity for endothelial cells., MMP-2 activity is associated with increase in MT2-MMP expression and with lymph node metastasis., a proportional significance of genetic polymorphisms in MMP-2 and MMP-9 genes in black and whitel subjects, MMPs are critical targets of diallyl disulfide-induced anti-invasiveness in human prostate cancer LNCaP cells., No significant differences were observed in MMP-2 frequencies/plasma levels between myocardial infarction patients and controls., The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression., The detected polymorphism in matrix metalloproteinase-2 gene was not associated with clinical response to cell therapy., High expression of MMP-2 and IGF-1 proteins is significantly correlated with the invasion and metastasis of gastric carcinoma., CD147 and MMP-2 play a role in invasion and metastasis of laryngeal carcinoma. Increased levels of MMP-2 and MMP-9 are induced by CD147 in laryngeal tumor cells., Inhibition of the PMA-Induced Expressions of MMP-2, MMP-9 and Cell Invasion, Migration via an Inactivation of the FAK/ERK Signaling Pathway by a-Mangostin, Visfatin enhanced the expression and activity of MMP-2 and MMP-9 in human monocytes via activating NF-kappaB signaling pathway., MMP-2 and MMP-9 in conjunction with VEGF-C, promote lymphangiogenesis and lymph node metastasis of breast cancer., An increase in MMP-2 mRNA and a decrease in TIMP-2 mRNA expression in uterosacral ligament are related to uterine prolapse in women without urinary incontinence., c-Cbl promotes glioma invasion through up-regulation of MMP2., Significantly higher venous levels of MMP-2 were associated with hemodialysis arteriovenous fistula maturation., Endothelin-1 is a lymphangiogenic mediator. Endothelin-1 induces MMP-2 and MMP-9 in lymphatic endothelial cells., 39% less extracellular MMP2 was measured from knockdown cells identifying one mechanism by which calpain 2 mediates glioblastoma cell invasion., No significant differences in either genotype distributions or allelic frequencies of MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R were found between patients with POAG and control subjects., The results obtained, therefore, rule out the existence of a negative correlation between ERK1/2 activation and MMP2 activity., metalloproteinase MMP-2 and MMP-9 -to-E-cadherin ratio has an effect on lymphangiogenesis and lymph node metastasis in prostate cancer, The association of polymorphism frequencies of MMP-2 C1306T and MMP-2 plasma enzyme activity in lung cancer patients, was investigated., Data show that a regulatory loop involving an opposing relationship between RKIP and the NF-kappaB pathway may control the level of MMP expression and cell invasion., Data show that mRNA expression of MMP-2 was only detectable in BL-28/0 and BL-13/0 bladder cancer cell lines., Low molecular-weight fucoidan increased in vitro human umbilical cell migration and decreased vascular smooth muscle cell migration in rats., Short-term use of statins is not associated in reducing levels of MMP 2 in areas of low and peak wall stress in patients with abdominal aortic aneurysms., High MMP2 is associated with peritoneal injury., TGF-beta1 induces dramatic elevation of MMP-2 activities and the MMP-2/tissue inhibitors of metalloproteinases ratio., Immunocytochemistry also revealed protein expression for MMP-2, 3, 8, 9 and 10 in cultured HUVEC., A positive correlation of serum MMP-2 with interleukin-1beta was observed with progressive-phase Guillain-Barre syndrome., extracellular Hsp90alpha promotes angiogenesis in an MMP-2-dependent manner., These results reveal a new mechanism by which beta3Gn-T8 can regulate MMP-2 and TIMP-2., results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma., our findings associate MMP-2 with glomerular injury as well as interstitial fibrosis and tubular atrophy observed in patients with chronic humeral kidney graft rejection., Thrombin-dependent MMP-2 activity is regulated by heparan sulfate, MMP-2 localizes to titin at the Z-disk region of the cardiac sarcomere and contributes to titin degradation in myocardial ischemia/reperfusion injury., Nicotinamide N-methyltransferase has a crucial role in cellular invasion via activating PI3K/Akt/SP1/MMP-2 pathway in clear cell renal cell carcinoma (ccRCC)., Restoration of MMP-2 expression in the Slug-silenced bladder cancer cells resulted in an increased cell angiogenesis., Expression of matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in papillary thyroid cancer, Data show there was a direct correlation between the degree of DSPP-silencing and suppression of MMP-2, MMP-3 and MMP-9., OPN enhanced hepatocellular carcinoma cells invasion through interaction with its receptor CD44v6 and increased MMP-2 and uPA expressions., These findings show that CK19 and MMP-2 expression may be beneficial in predicting lymph node metastasis in hepatocellular carcinoma and survival., The content of matrix metalloproteinases (MMP) -2, -7, and -9 was signifi cantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer., The present investigation is the first report to detect an association between MMP2 promoter polymorphisms and CAD with or without MI history in the Turkish population, Release of metalloproteases-2 and -9 is blocked after silencing of the kinin B1 receptor with a siRNA., the multifactor interactions among polymorphisms in MMP-2, FASL and FAS are associated with gastric cardia adenocarcinoma., MMP-2 expression thus appears to confer enhanced vascular proliferation particularly at the brain-tumor interface., reduced content of MMP-2 in ovarian cancer tissue compared to benign tumors were demonstrated by enzyme immunoassay. After preoperation chemotherapy the level of MMP-2 increased, Specific suppression of osteopontin also inhibited matrix metalloproteinase 2 (MMP-2) and urokinase-type plasminogen activator (uPA) expression in HCCLM6 cells., plays an important role in invasion and metastasis in squamous cell carcionoma of the tongue, results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 expression and enhance ovarian cancer cell invasion, MMP-2 inhibitor suppressed the Wnt-5a-dependent invasion of U251 cells, MMP2 and MMP3 genes do not correlate with a genetic risk of coronary restenosis after successful percutaneous coronary intervention., The increased MMP levels in our MG patients...suggest that MMP2, MMP3 and MMP9 play a role in the development of myastenia gravis, two SNPs on matrix metallopeptidase 2 gene and one SNP on tumor necrosis factor-alpha gene, are marginally associated with intracranial aneurysm in male- and female-specific manner, Phytic acid modulates MMP-2 gene expression in colon cancer cells at the transcriptional level in a way dependent on its concentration and time of interaction., The effect of estradiol on prostate cancer cell invasiveness via upregulation of MMP2 via a paracrine mechanism is reported., Specific single-nucleotide polymorphism in TIMP2 and MMP2/9 appeared to be associated with tumorigenesis and biological behavior in colorectal cancer., The expression of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin., Ursolic acid downregulated the expressions of MMP-2 and MMP-9 in ovarian carcinoma cells., Akt-dependent mechanisms of interference with motility/invasion of human glioblastoma cells, Resistin-stimulated vascular smooth muscle cell migration was associated with increased MMP expression, which was dependent on PKCepsilon activation., The findings suggest that matrix metalloproteinase 2 polymorphisms affect hypertension-induced left ventricular remodelling., The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. It is suggected BAG3 binds to MMP2 to positively regulate the process of cell invasion., MMP-2 is differentially expressed in central and peripheral regions of gliomas, A prognostic index in skin melanoma through the combination of matrix metalloproteinase-2, Ki67, and p53., MMP2 polymorphism is not associated with breast cancer., CD147 and MMP-2 were co-localized in spermatogonia, spermatocytes and round spermatids in mouse testis, while in human testis, they were co-localized in spermatocytes and round spermatids., mechanical injury, HIF-1alpha and inflammatory factors collectively induce increased MMP-2 production in anterior cruciate ligament fibroblasts, Des-gamma-carboxyl prothrombin stimulates HCC growth and promotes HCC metastasis by increasing the activity of MMP-2 and MMP-9 through activation of the ERK1/2 MAPK signalling pathway, Regions of aberrant DNA methylation which were consistent with alteration of TGM-2, MMP-2, and CD24 transcript and protein expression., There was no association between the genotypes of the MMP2, VEGF and HIF1A SNP and clinicopathological parameters of colorectal cancer., Overexpression of MMP-2 and MMP-9 are often associated with increased invasive metastatic potential of colorectal adenocarcinoma., Data show that MMP-2-conditioned dendritic cells primed naive CD4(+) T cells to differentiate into an inflammatory T(H)2 phenotype through OX40L expression and inhibition of IL-12p70 production., Results showed that exposure of human monocyte U937 to Nano-Ni caused dose- and time- dependent increase in MMP-2 and MMP-9 mRNA expression and pro-MMP-2 and pro-MMP-9 activity., Doxycycline reduced MMP-2 from MEFs and decreased active-MMP-2 from LAM cells., MMP2, TIPM2, and TIMP3 genes were not associated with high myopia in this Chinese sample and hence are unlikely to play a major role in the genetic susceptibility to high myopia., MMP-2 concentrations were lower in the plasma of patients with inguinal hernia and abdominal aortic aneurysm than controls., differences in histological features between nasal polyposis and chronic rhinosinusitis might be related to the expression of MMP-1, MMP-2, MMP-8 and their tissue inhibitor-2, Data indicate that the balance between MMPs and TIMPs in women with PCOS is altered, probably due to androgen excess found in these women., results indicated that WISP-1 enhances the migration of chondrosarcoma cells by increasing MMP-2 expression through the alpha5beta1 integrin receptor, FAK, MEK, ERK, p65 and NF-kappaB signal transduction pathway, MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of subcortical ischemic vascular disease., data demonstrate, for the first time, that DDR1 mediates MMP-2 and -9 secretions and invasion induced by native type IV collagen in MDA-MB-231 breast cancer cells, Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., The results showed that MMP-2 was significantly higher in the cases with vulnerable atherosclerotic plaque than in the cases with stable plaque., Results indicate the better usefulness of TIMP-2 than MMP-2 in the diagnosis of colorectal cancer, especially in combined use with classic tumor marker of CRC, e.g. carcinoembryonic antigen., A significant association of MMP-2 (-1306C/T) polymorphism with glioblastoma multiforme was not found, suggesting that MMP-2 (-1306C/T) polymorphism is not associated with increased GBM susceptibility., MMP2 levels are elevated in patients who experience atrial fibrillation recurrence after ablation., Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways, Both MMP-2 and MMP-9 were associated with the leukocyte count in pre hemodialysis group., The aim of this study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed., G-CSF-induced MMP-2 upregulation and invasive phenotype is mediated by Rac1., results suggest the greater importance of serum MMP-2 than of the classical tumor markers CEA and CA 19-9 in the diagnosis of gastric cancer, MMP1 and MMP2 may be useful biomarkers that can help stratify patients at higher risk of developing recurrence in colorectal cancer, and guide individualized treatment decisions to achieve better outcomes., Metastasis formation upon up-regulation of full length-L1CAM correlated with increased invasive potential and elevated Matrix metalloproteinase (MMP)-2 and -9 expression and activity., Matrix metalloproteinase-2 in preoperative serum is independent prognostic markers in patients with colorectal cancer, Serum MMP-9 level is a better marker than serum MMP-2 in predicting the breast cancer development and progression., Data show that suppression of microglial MMP-2 secretion by M tuberculosis-infected monocytes involves the pro-inflammatory mediators TNF-alpha, p38 MAP kinase and NFkappaB in addition to a novel caspase 8-dependent pathway., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., Expressions of LOX and MMP-2 in gastric cancer tissues are significantly higher than that in pericancerous tissues, and are also higher in gastric cancer with lymph node metastasis., There was no significant effect of MMP2 polymorphisms on mRNA expression., Knockdown of AURKA inhibits the growth and invasiveness of this LSCC cell line both in vitro and in vivo. These effects may partially result from the reduced expression of FAK and MMP-2., Coexpression of MMP-2/MMP-9 correlated significantly with tumor size in breast cancer., The allele frequency of MMP2 rs243865 was not associated with the development of gastric cancer or its lymph node metastases. Epistasis between PARP1 rs1136410 & MMP2 rs243865 increased the risk of LNM of GC., Serum levels of MMP-2/TIMP-2 were significantly higher in patients with matured arteriovenous fistulas vs levels in those that failed., The effects of rosuvastatin in reducing MMP-2 and MMP-9, which might stabilize the atherosclerotic plaques, are dose-dependent., There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues., MMP2 showed an increase in amniotic fluid of Down syndrome pregnancies., HABP1 enhanced melanoma cell migration, leading to MMP-2 activation and tumor growth., Although MMP-2 positivity was observed in 2 malignant cases, CD44 positivity was not associated with malignancy criteria in solitary fibrous tumors, Fluid shear stress in the tumor microenvironment may explain reduced glioma invasion through modulation of cell motility and MMP levels., The MAPK signaling pathway is a potential key intracellular modulator of Ang II-induced increase in MMP-2 activity and MMP-14 and BSG protein expression., Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis., The expression of COX-2, MMP-2 and VEGF in colorectal cancer plays a synergistic promoting effect on the malignant biological behavior of tumors., In conclusion, MMP-2 expression was related with worse overall and disease-free survival and could be considered as a potential marker of poor prognosis., Soluble endoglin may participate in the genesis of preeclampsia by affecting the invasive ability of cytotrophoblasts through regulation of the expression of MMP-2 and MMP-9., Results show that SLPI promotes the metastasis of SNU638 gastric cancer cells by increasing MMP-2 and MMP-9 expression through Elk-1 signaling, indicating its role as a signaling molecule not a protease inhibitor., This is the first report of a change in MMP-2 activity in Alzheimer's disease plasma and these findings may provide some insight into Alzheimer's disease pathogenesis, human leukemic Jurkat, U937 and Molt-4 cells display gene activity with different degrees, MMP-2 expression within and around amyloid-beta compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding., Findings show that the combination of intratumoral HIF-1alpha, VEGF, and MMP-2 may be useful as a molecular prediction model for LNM., Tumor MMP-2 high expression was not significantly correlated with poorer outcome in stage IA non-small cell lung cancer., meta-analysis showed evidence that MMP2 -1306T allele may be a protective factor for digestive cancer risk as well as a low-penetrance susceptibility digestive cancer biomarker, basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium, Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras., Two strongly linked snps in MMP9 showed significant associations with subarachnoid hemorrhage in men, MMP-2 genotype of donor and recipient is an independent risk factor for the development of nonanastomotic biliary stricures after orthotopic liver transplantation., AEG-1 plays a crucial role in osteosarcoma progression through upregulation of MMP-2, activated platelets may be a major source of MMP-1 and to a minor extent MMP-2, in peripheral blood., IL-17A could upregulate MMP2 and MMP9 expression via NF-kappaB signaling activation., results suggested that hypoxia might inhibit the invasive capacity and MMP2 activation of extravillous trophoblast cells in the early first trimester of pregnancy., Expression and activity of MMP-2 are strongly increased after exposure of human saphenous vein grafts to arterial hemodynamic conditions., Results suggest that decreased E-cadherin and increased MMP-2 may be associated with the capacity of GCSCs to metastasize., Our data suggested that variant allele of MMP2 1306C > T was associated with high risk of tumor recurrence and reduced recurrence free survival in superficial bladder cancer patients, results suggest that the MMP2 C(-1306)T polymorphism interacts with Hg exposure and affects MMP-2 and MMP-2/TIMP-2 levels; this interaction may increase the risk of developing diseases in subjects with the C allele, The crystal structure of the catalytic domain of MMP-2 in complex with APP-IP, was determined., Unlike in their adult counterpart, the expression of matrix metalloproteinase 2 or the loss of HLA class II antigens does not discriminate between benign and malignant tumors in children., The C-terminal domain of TIMP-2 inhibits cell surface activation of proMMP-2., overexpression of serum response factor in hepatocellular carcinoma may play an important role in tumor cell migration and invasion through upregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, Data suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS., Data show that CC and DW increased MMP-2 and MT1-MMP expression., Data show that kahweol inhibits HUVEC MMP-2 and urokinase involved in angiogenesis., The MMP2 -1306C/T promoter polymorphism is associated with nasopharyngeal carcinoma risk, and this association is especially noteworthy in heavy smokers., study demonstrates the potential utility of urinary MMP-2 and MMP-9 to differentiate between ovarian cancer patients with normal CA125 levels and controls, fibulin-3 negatively modulates the invasiveness of lung cancer cells via regulation of MMP-7 and MMP-2 and its expression is regulated by hypermethylation of the promoter region, MMP-2 levels may be of value in understanding the pathogenesis and progression of alcoholic cirrhosis, Recombinant human osteopontin up-regulates MMP-2 through the SDF-1alpha/CXCR4 axis., CD147 and MMP-2 expression is correlated with the invasion and metastasis of squamous cell carcinoma and adenocarcinoma of the lungs, Report activity of MMP2/9 and TIMP-1 in electromagnetic field-exposed THP-1 cells., mRNA and protein levels of MMP-2 in hypoxic cells increased in both anterior cruciate ligament (ACL) and medial collateral ligament cells, however, in ACL pro-MMP-2 was converted into a more active form, This is the first study to show that endogenous nitric oxide formation correlates negatively with the circulating levels of both MMP-2 and MMP-9 in black subjects, These data testify to the important role of metalloproteinases 2 and 9 in extracellular interaction and proliferation activity in thymus aging., Data show that SNPs in the MMP-2 and -9 promoter region may be associated with susceptibility to and neck squamous cell carcinoma not in oral submucous fibrosis., study identified urotensin-II and NOX4 as new activators of FoxO3a, and MMP2 as a novel target gene of FoxO3a, and showed that activation of FoxO3a by this pathway promotes vascular growth, Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.(, analysis of secretory dynamics of MMP-2 and the specific sites for polarized distribution of MMP-2 on the cell surface, Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9., Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis., The results suggest that the main proteolytic cascade, MMP-2/MMP-13/MT1-MMP is involved in osteoblast differentiation through mechanical forces., A significant inverse relationship between miR-29a and total MMP-2 was identified in the thoracic aortic aneurysm specimens., Matrix metalloproteinase-2 promoter gene polymorphisms are associated with non-Hodgkin's lymphoma., MMP-2 might be a prognostic marker in ascites of advanced gastric patients with disseminated metastasis., The role of MMP-2 expression in the prognosis of invasive ductal carcinoma of the breast is rather limited., no significant association was observed between MMP-2 polymorphisms and treatment efficacy, including response rate, clinical benefit, progression-free survival, and overall survival., MMP2 and neutral sphingomyelinase-2 play a role in vasculopathy triggered by a humoral immune response in transplants., Zoledronic acid can inhibit the in vitro proliferation and invasion of HNE1 cell through suppressing the secretion of VEGF and suppressing MMP2 and MMP9 activity., NDRG2 contributed to an increase in the ratio of matrix metalloproteinase 2 (MMP2) to tissue inhibitor of matrix metalloproteinase 2, Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis, There was no association of MMP2 polymorphism and occurrence and development of gastric cancer., COX-2 and MMP-2 produced from human brain endothelial cells facilitate the extravasation of breast cancer cells across the BBB, an increase in the immunodistribution of MMP-2 and -9 and TIMP-1 and -2 in lichen sclerous compared to normal vulvar skin was observed., ADAM17 contributes to androgen-independent prostate cancer cell invasion by shedding of EGFR ligand TGF-alpha, which subsequently activates the EGFR-MEK-ERK signaling pathway, leading finally to overexpression of MMP-2 and MMP-9., Failed to demonstrate any prognostic relevance of MMP2 levels in advanced epithelial ovarian neoplasms., Abnormal expressions of MMP-2 and TIMP-1 can promote the development of renal fibrosis in chronic active antibody-mediated renal graft rejection., Paroxysmal atrial fibrillation (AF) was associated with higher MMP-2 levels compared to permanent AF., Human cardiomyocytes express an MMP-2 splice variant which entirely lacks the signal sequence., AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9., Data show that Tissue factor (TF) down-regulation diminished matrix metalloproteinases MMP-2 and MMP-9 expression and promoted reversion to suspension growth., No correlation was found between pinopodes development stage and MMP2 expressions in endometrium, It is concluded that MMP-2 may be involved in ADM resistance dependent on ERK1/2 signal pathway, suggesting interference in ERK1/2 may be a new method of targeted therapy for tumor resistance., Between two of the tested metalloproteinases (MMP-2 and MMP-11) only MMP-2 appears to have prognostic significance in early forms of breast cancer, and its strong expression is associated with shorter survival., This study demonistrated that Expression of MMP-2 was significantly more extensive in mesenchymal than in glial tumor areas., These findings suggest that corticotropin-releasing hormone might induce invasion and migration by upregulating MMP-2 and MMP-9 in endometrial cancer., HDAC inhibitor trichostatin A (TSA) increased the expression of TIMP-1 and TIMP-3 while decreased MMP-2, MMP-9 and uPA and have an inhibitory effect on trophoblast invasion., MMP-2 genotypes or haplotypes modify MMP-2 levels in end-stage kidney disease patients. The T allele for the C-735T polymorphism and the C-T haplotype were associated with higher MMP-2 levels (p < 0.05), whereas the C-1306T had no effects., close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues of uterine leiomyomas., results are the first to demonstrate that triple-helical peptides are suitable for highly specific in vivo detection of tumor-related MMP-2 and MMP-9 activity, Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosus patients., Pregnant women with pre-eclampsia had higher plasma MMP-2 and TIMP-2 concentrations than healthy pregnant women. MMP-2 genotypes and haplotypes were associated with significant alterations in plasma MMP-2 and TIMP-2 concentrations in preeclampsia., Activated MMP-2 in hyperostotic lesions may change the physiological metabolism of the skull bone, thus playing an important role in hyperostosis formation., Blocking the FAK signaling pathway can reduce the activity of MMP-2 and -9 in corneal epithelium treated with TNF-alpha., study concludes that MMP-14 (via its ability to activate proMMP-2) and MMP-2 are key proteases in collagen contraction mediated by fibroblasts in Dupuytren's disease patients., the possible role of MMP-2/alpha5beta1 interaction in the regulation of alpha5beta1-mediated IL-6/Stat3 signaling activation, findings suggested MMP2 variants as a predictor of PCa progression risk among North Indian men, expression correlates with severity of chronic rhinosinusitis with nasal polyposis, Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2, the present study shows for the first time that MMP-2 and -9 give a main contribution to estrogen's neuroprotective effect., MMP2 -735 C/T and MMP9 -1562 C/T functional gene polymorphisms might be associated with an increased risk of idiopathic recurrent spontaneous abortion in women., Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of Behcet Disease, while MMP-9-1562*C/*C may promote the disease., that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner., The MMP2 -735 T/T genotype was statistically significantly associated with a decreased survival in non-small cell lung cancer (NSCLC), The highly significant correlation between VEGF and MMP-2 suggests a connection between both mechanisms in the progression of gastric cancer., High MMP-2 is associated with colorectal cancer., New mechanistic insight into how lymphatic endothelial cells negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis., Notch1, MMP-2 and MMP-9 are closely correlated with the progression and prognosis of malignant gliomas. Notch1 may participate in the expression regulation of MMP-2 and MMP-9., COUP-TFII negatively regulates osteoblast differentiation via interaction with Runx2, and during the differentiation state, BMP2-induced Runx2 represses COUP-TFII expression and promotes osteoblast differentiation., A novel N-terminal truncated intracellular isoform of MMP-2 is induced by oxidative stress., Serum vascular endothelial growth factor (VEGF)-D is significantly elevated in patients with lymphangioleiomyomatosis and is a better diagnostic marker than matrix metalloproteinase (MMP)-2, MMP-9 and ACE., Nox1 was overexpressed in all melanoma cell lines examined, and enhanced cell invasion by MMP-2 upregulation and EMT induction, Variations in MMP2 are associated with periapical lesion formation in individuals with untreated deep carious lesions., These results suggested that the inhibition on proMMP-2 expression by Liquiritigenin may be through suppression on PI3K/Akt signaling pathway, which in turn led to the inhibition of lung adenocarcinoma A549 cells migration., These data show that overexpression of Aurora-A contributes to the malignancy development of ESCC by enhancing tumor cell invasion as well as MMP-2 activity and expression, COX-2 increased the expression of MT1-MMP, which in turn activates MMP-2, the release of pro-inflammatory TNF-alpha, MMP-9, and MMP-2 was higher in cells exposed to oxidized high density lipoproteins (HDL) than those exposed to native HDL, noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells, The increased expression of MMP2 plays a crucial role in the development of several human malignancies, including esophageal cancer., VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2., Enhanced stromal MMP-2 expression in in situ and invasive squamous cell carcinoma relative actinic keratosis suggests role in disease progression., Grp78 knockdown inhibited ECM degradation and the decreased activity and expression of MMP-2, Inhibition of MMP-2 by doxycycline delays the progression of Marfan syndrome., cysteine-rich angiogenic inducer 61 may promote trophoblast cell migration and invasion through upregulation of NUR77 protein leading to the increase of matrix metalloproteinase 2(MMP2) release and the downregulation of tissue inhibitor of MMP2 expression, Our experimental data suggest a novel regulatory mechanism for pro-MMP-2 activation that is modulated through homodimerization of MMP-2., We detected reduced plasma levels of zinc and MMP-2, and enhanced plasma levels of SOD in patients with keratoconus compared with the healthy subjects., Data show that angiotensin II through activation of AT1 receptors can stimulate the expression of MMP-2, MMP-13 and VEGF, but not MMP-13, in B16F10 melanoma cells., MMP2 plays a critical role in TGFbeta2-mediated matrix contraction. MMP2 inhibition provides a novel strategy for the treatment of PCO and potentially other fibrotic disorders., This study suggests that genetic variants in MMP-2,7,9 and TIMP-2genes are associated with higher susceptibility of gallbladder cancer., Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10., finding of increased plasma activity of matrix metallopeptidase 2 in overweight/obese women, associated with menopausal status, is important given that it fits in with an early stage of cardiovascular disease, Platelets do not possess the transcriptional activity of a gene encoding MMP-2., MMP-2 is involved in the granulocyte-colony stimulating factor stimulation of trans-stromal migration of hematopoietic cells., hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK activation in pancreatic cancer, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Strong MMP2 staining is associated with worse survival of melanoma patients., MMP-2 polymorphisms do not affect the susceptibility to hypertensive disorders of pregnancy, nor do polymorphisms affect the responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy., SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell., basal lamina type IV collagen alpha chains, matrix metalloproteinases-2 and -9 expressions are expressed in oral dysplasia and invasive carcinoma, Data suggest that lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of MMP-2 and urokinase-type plasminogen activator via vascular endothelial growth factor receptor 2 signaling., Low MMP-2 plasma levels are associated with intracranial location of cerebral atherosclerosis., Serum MMP-2 and PAPP-A were independent correlates of proteinuria, albumin, and other examined parameters in patients with chronic kidney disease., The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction., Roles for MMP-2 and TIMP-2 in both thyroid development and malignant transformation., Glut-1 may regulate MMP-2 and MT1-MMP expression in laryngeal carcinoma., MMP-2 over-expression is a poor prognostic factor for survival in patients with colorectal cancer., This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis., MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., fluid shear stress involved in PDL remodeling via regulating MMP-1, 2 and TIMP-1, 2 expression. ERK regulated fluid shear stress induced MMP-1 expression and P38 play a role in fluid shear stress induced MMP-2 upregulation., MMP-2 and MMP-9 downregulation in gallic acid treated K562 cells are mediated through suppression of JNK1-mediated c-Jun/ATF-2 and Akt/ERK-mediated c-Jun/c-Fos pathways, respectively., MMP2 mutations can result in osteolytic disorders., LOX, MMP-2, and MMP-9 may have a synergistic role in promoting invasion and metastasis of breast cancer., MMP-2, MMP-9 and TIMP-2, TIMP-1 may play an important role in the development, progression, invasion and metastasis of non-melanoma skin cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., High MMP2 expression is associated with follicular thyroid carcinoma., Data suggest that OSM enhances invasion activities of extravillous trophoblasts during placentation through increased enzyme activity of MMP-2 (primarily) and MMP-9 (to some extent)., with the exception of MMP-2, this study confirms the importance of MMPs in development of preeclampsi, currently available evidence supports the conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians, High MMP2 expression is associated with hepatocellular carcinoma invasion., Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways., patients with cardioembolic stroke had significantly higher MMP-2 concentrations in comparison to all other stroke subtypes, synergetic pathways of IL-17A and hypoxia might contribute to the migration and invasion of rheumatoid arthritis synoviocytes by up regulating the expression of MMP2 and MMP9 by activation of the NF-kappaB/HIF-1alpha pathway, MMP2 expression in tumor infiltrating CD3 lymphocytes is not associated with endometrial cancer., This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer., gene polymorphism is associated with advanced-stage endometriosis in Korean women, Data show that knockdown of CD147 inhibited MMP-2 activity of GnT-V-overexpressing cells, indicating that aberrant beta1,6-branches on CD147 is crucial for the induction of MMPs (matrix metalloproteinases) in SMMC-7721 cells., Data indicate that calpain-1 plays a pivotal role in matrix metalloproteinase 2 (MMP2) activation and extracellular matrix remodeling, including fibrosis and vascular calcification., Temocaprilat bound to the MMP-2 active centre., SIRT1 is an important regulator of MMP2 expression, activity, and prostate cancer cell invasion., the CC genotype for C(-735)T polymorphism and the CC haplotype were associated with higher plasma MMP-2 concentrations in MA group., Abnormal expression of MMP-2 and TIMP-1 might play roles in the development of renal fibrosis in chronic antibody-mediated renal graft rejection., study investigated the role of uPA, PAI-1, MMP-2, and TIMP-2 in formation of self-assembled network in the 2D co-ulture of bone marrow stromal cells and HUVECs; data showed that uPA played an important role in network formation, while the process appears independent on TIMP-2 but involved MMP-2, MMP-1, MMP-2 and MMP-9 were significantly more expressed in nasal polyps than in controls., After exposure to hypoxia, HIF-1alpha protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1alpha mRNA showed no significant change, Report up-regulation of MMP-2 in hidradenitis suppurativa., Variants in MMP1 through MMP10 and MMP2 regions seem to affect population variation in ocular refraction in environmental conditions less favorable for myopia development., No difference was found among groups for serum MMP2 for Takayasu arteritis., Degradation of ColIV was closely related to increased MMP-2 and MMP-9 expression; MMP-9 have more important function than MMP-2 during the cancer development, Data suggest that MMP2 and MMP9 have dual roles in Trypanosoma cruzi infection of placental chorionic villi; these enzymes may be partially responsible for invasion of extracellular matrix and may be part of local placental antiparasitic mechanism., alpha-Tomatine inhibited 12-O-tetradecanoylphorbol-13-acetate-induced expressions of MMP-2 and MMP-9 in MCF-7 cells., Mere15 inhibits tumor growth via both pro-apoptotic and antimetastasis pathways by reducing MMP2/9 expression., In patients with NASH, gene expression of MMP2, a protein associated with liver fibrosis, was enhanced in the liver tissue and serum levels of MMP2 were increased, indicating the initiation of liver fibrosis in this subpopulation, Heavy smoking noticeably increases native MMP2 and MMP9 gene expression in the SV before CABG., The expression of Twist1 has a close relationship with MMP-2 in endometrial endometrioid adenocarcinoma., Presented data suggest an implication of MMP-1 polymorphisms in the laryngeal carcinoma susceptibility. The presence of the MMP-1 2G allele seemed to be associated with increased risk for the disease., NK1R is a potential regulator of human glioma cell migration by the up-regulation of MMP-2 and MT1-MMP, Advanced pelvic endometriosis severity is related to higher serum MMP-2 levels but does not influence follicular MMP-2 or MMP-9 levels in periovulatory follicles obtained from stimulated cycles., MMP-2 overexpression is associated with poorer overall and progression-free survival in patients with CRC., Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., miR-200b enhances matrix metallopeptidase 2 (MMP2) activity by downregulating TIMP2 expression in endometrial adenocarcinoma HEC-1A cells, our findings have identified inhibition of MMP-2 and -14 expression and MMP-dependent migration as a novel mechanism by which angiostatin inhibits angiogenesis under pathological-like conditions., expression of MMP2 protein was inhibited by knockdown of MACC1 protein expression in hepatocellular carcinoma cells, blood pressure is associated with circulating MMP-2, the CC genotype for the C(-1306)T polymorphism was more common subjects with higher MMP-2 concentrations, the CT genotype and the T allele for the C(-735)T polymorphism are less common in obesity., Interaction between PAK4 and MMP-2 regulated anoikis, cell migration and invasion in glioma., There was no significant difference in MMP-9 and MMP-2 expressions between recurrent and nonrecurrent nasal polyps., these findings demonstrate that normal and tumor prostate cell lines express MMP2 activity when in contact with extracellular matrix components or blood plasma proteins such as fibronectin, The aim of the present study was to investigate the diagnostic significance of MMP-2 and TIMP-2 serum levels in esophageal cancer patients in relation to clinico-pathological features of cancer., The aim of this study is to demonstrate a relationship between MMP-2 secretion and activation and changes of glutathione/oxidized glutathione ratio in intestinal subepithelial myofibroblasts., We conclude that MnSOD may promote tumor aggressiveness via upregulation of the FoxM1-MMP2 axis, and that MnSOD expression can independently predict survival and relapse in patients with resected lung adenocarcinoma., p53, MMP-2 and MMP-9 can be used for the histological grading of oral Squamous cell carcinoma and its differentiation from Verrucous carcinoma, analysis revealed that MDR1 expression in lymph node was not correlated with MMP-2 expression in lymph node, number of metastasized lymph nodes and tumor size, our study suggests that evaluation of beta-catenin and MMP-2 expression may have potential in diagnosis and progression in patients with non-small cell lung cancer., Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9., MMP2-1306 C/T polymorphism decreased lung cancer risk in Asians., elevated levels of matrix metalloproteinase 9 and matrix metalloproteinase 2/tissue inhibitor of matrix metalloproteinase-2 complex may play a role in spontaneous termination of pregnancy, MMP-2 secretion is decreased in multiple myeloma after treatment with anti-angiogenic agents, expression correlates with clinical stage in non-small cell lung cancer, HPV 16 E6 up-regulates pro-angiogenic MMP-2 and MMP-9 through inducing IL-8 expression in lung cancer cells., TGF-beta1 induced injured ACL to express more MMPs than injured MCL fibroblasts (up to 2.33-fold in MMP-1, 2.45-fold in MMP-2, 1.89-fold in MMP-3 and 1.50-fold in MMP-12), A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women, Low MMP2 levels are associated with grade 3 breast tumors., MMP2 is responsible for high myopia in these Han Chinese subjects and hence is unlikely to be important in the genetic predisposition to high myopia., The role of MMP-2 in the regulation of SDF-1/CXCR4 signaling-mediated angiogenesis in endothelial cells., the evaluation of MMP2 in thyroid Papillary thyroid carcinoma appears to be of some benefit to the prediction of tumor behavior while Caspase-3 as a marker of prediction seems to be of no use., MMP-9 and MMP-2 are highly expressed by myeloma cells., The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma., Report MMP2 activity in chronic pancreatitis and pancreatic adenocarcinoma., High stromal MMP 2 expression were identified as a significant determinant for endometrial cancer recurrence, while epithelial MMP 2 expression and epithelial and stromal MMP 9 expression were not., analysis of a highly selective and strong protein inhibitor against matrix metalloproteinase-2, Placental MMP2 and MMP3 levels are higher in women delivering preterm as compared with term and may favor degradation of extracellular matrix in the placenta during preterm labor., hCGbeta induced cell motility via promoting ERK1/2 phosphorylation and MMP-2 upregulation in human prostate cancer DU145 cells., MMP-2 is upregulated in brain microvascular endothelial cells following induction of basement membrane hypertrophy by advanced glycation end-products., The expression of pro-invasive gene matrix metalloproteinases 2 is also reduced by miR-22 expression., Decreases in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes increase the risk for lung cancer., PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells., liver chimerism in MMP-2 was found to be significantly associated with the development of acute cellular rejection after orthotopic liver transplantation., Hypomethylating drug 5-azadC and histone deacetylase inhibitor trichostatin A induced modulations in higher order chromatin organization and in MMP-9 and MMP-2 expression in human HT1080 fibrosarcoma cells., Simvastatin and rosuvastatin significantly and dose-dependently reduced RAS protein, MMP-2/9 and NF-kappaB-p65 expression in tumor cells., role of SPARC, MMP-2 and MMP-9 in intracranial aneurysms, MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants are unlikely to have a major role in age-related macular degeneration risk susceptibility., the inhibitory effect of TSA on cancer invasion is mediated through the suppression of HDAC2 expression, and the reduction of MMP-2 and MMP-9 expression induced by HDAC2 may be involved in the anti-invasive effect of TSA, Increases in circulating MMP-2 are associated with poor oocyte and embryo development in women with endometriosis undergoing in vitro fertilization., This pilot study first reveals a link between increased levels of circulating gelatinases (MMP2 and MMP9) and polypoidal choroidal vasculopathy but not age-related macular degeneration., Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression., Daidzein, R- and S-equol inhibit the invasion of MDA-MB-231 human breast cancer cells in part via the down-regulation of MMP-2 expression, with equipotent effects observed for the parent isoflavone daidzein and the equol enantiomers., Increased MMP2 expression was found in nasopharyngeal carcinoma. In lymph node metastatic NPC, NPC cells had a higher rate of MMP-2 expression in tumor metastases than in the primary tumor., Positive correlations of MMP1, TIMP1 and 2 with pancreatic tumor diameter (CP) were observed, and MMP2 with the duration of surgery and blood loss, MMP-2 EPHA2 signaling contributed to tumor growth and vasculogenic mimicry of gallbladder carcinomas., MMP-2 positivity in tumor cells is associated with worse survival in patients with gynecological cancers., FRET sensors fabricated through physical adsorption, the as prepared ones via covalent binding are significantly more stable under physiological conditions, enabling their detection of MMP-2 with high sensitivity (detection limit, the MMP2-1306 C>T polymorphism is associated with the risk of HNC, as is the MMP3-1171 5A>6A polymorphism specifically in some subgroups. However, the MMP9-1562 C>T polymorphism is not associated with HNC risk., Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas, Although extracellular galectin-3 accumulates due to the decrease in MMP-2 activity, galectin-3 signaling events are blocked due to an impaired interaction with 4F2hc, inducing an increased degradation of beta-catenin., The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas., MMP-2 -1306C > T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed., MMP-2 plasma levels are significantly increased in metabolic syndrome., Uterine leiomyosarcoma showed strong bands corresponding to inactive and active MMP-9 and a faint band corresponding to MMP-9 dimer induced with PMA treatment, but no MMP-2 band., Data indicate that a 2-week course of antibiotics and corticosteroids effectively improves the uterine environment underlying recurrent implantation failure (RIF) by reducing MMPs MMP2 and MMP9 activity., The levels of MMP2, MMP9, TIMP1, and TIMP2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those with benign thyroid disease and healthy volunteers., The MMP-1,2 levels were statistically higher in epitheliocytes, macrophages and capillaries endotheliocytes in all instances not depend on the sex and correlate with mucosa disease activity, IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2, Up-regulation of both MMP-2 and CD44v6 is significantly correlated with the development of lateral cervical lymph node metastasis in patients with papillary thyroid carcinoma., The PAK5-Egr1-MMP2 signaling pathway is a critical regulator of cell migration and invasion in lung cancer cells., MMP1 [4 single nucleotide polymorphisms (SNPs)] and MMP2 (2 SNPs) were associated with breast cancer overall., enzyme activity assays confirmed increased MMP-1, -2, and -3 activity in cancer myofibroblasts, and cancer cell migration assays indicated stimulation by MMP-1, -2, and -3 in cancer-associated myofibroblast media., Glycosylation of teh extracellular domain of EMMPRIN is a prerequisite for efficient MMP-2 production., Our data suggest that gene polymorphisms of MMP-2 may have a protective role in the progression of primary open-angle glaucoma in a Polish population., Suggest that miR-491 is involved in metastasis of hepatocellular carcinoma by blocking epithelial to mesenchymal transition and decreasing MMP2/9 levels., RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells., Positive expression rate of MMP-2 in gastric cancer tissues was 44.35%, negative in normal gastric tissues., This study suggests an effective link between MMP-2 and HLA-G1 shedding., These data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal role for PRL-dependent PAK1 tyrosyl phosphorylation in MMP secretion., The cold chloroform extract of Lansium domesticum appeared to contain anticancer active compounds against KB cells because of its high anti-proliferative and MMP-2 inhibition activities., Androgen blockade decreases serum PSA by eliminating HER-2 negative prostate cancer cells., Highest concentration of MMP-2 was found in patients with unresectable pancreatic cancer., Distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia predict that this enzyme determines the presence of multi-organ failure of the connective tissue., Dihydrotestosterone levels differentially affected the expression of regulatory isoforms responsible for the activation and inhibition of MMP-2., MMP2-1306C/T, but not TIMP2G-418C, gene variants are a risk factor for the development of retinal vein occlusion., increased expression of MMP-2 metalloproteinases is responsible for disturbed equilibrium of the metalloproteinase/tissue inhibitors system and as a consequence, for destabilization of atherosclerotic plaque and occurrence of the acute coronary syndrome, we use real-time PCR and Western blotting to demonstrate for the first time that MMP-2 expression is regulated by MT1-MMP in human endothelial cells, Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2,-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 cells., the shRNA-mediated inhibition of Bmi-1 reduced the invasiveness of two HCC cell lines in vitro by downregulating the expression and activities of matrix metalloproteinase (MMP)-2 and MMP-9 and vascular endothelial growth factor (VEGF)., Matrix metalloproteinase-2 C to T-1306 gene promoter polymorphism in primary sclerosing cholangitis is an independent risk factor for disease severity as reflected by the need for transplantation or disease progression leading to mortality., Data suggest active form of vitamin D, 1,25-dihydroxy-vitamin D3, down-regulates expression of MMP2 and MMP9 in uterine fibroid/neoplastic cells; 1,25(OH)2-D3 inhibits activities of MMP2/MMP9 via up-regulation of TIMP1/2 (tissue inhibitors of MMPs)., Data suggest that expression of CXCL6 (granulocyte chemotactic protein 2) in trophoblasts is up-regulated during pregnancy placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2., human brain microvascular endothelial cells switch to a proinflammatory state by means of an enhanced production of MMP-2, attenuated release of TIMP-1, and unaffected production of TIMP-2, PTEN and MMP-2 immunoexpression in ectopic endometrial foci cannot be used to identify women with an increased risk of neoplastic transformation., S100A4 plays a crucial role in proliferation and migratory, invasive processes in human renal cell cancer by a mechanism involving activation of NF-kB-bcl-2 and NF-kB-MMP-2 pathway, data imply that MMP-2 and MMP-9 activities may play a role in the pathogenesis of ventricular septal defect, polymorphism of MMP2 may be associated with the risk and severity of lumbar disc degeneration in the Chinese Han population, Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2., Estrogen increased the expression of VEGF, and thus activate ERK1/2 pathway to induce MMP-2/9 expression., MMP2 was upregulated in osteosarcoma., HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis, U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer, Rab40b mediates trafficking of MMP2/9 during invadopodia formation and metastasis of breast cancer cells., Both cathepsin L and matrix metalloprotease-2 showed correlation with some of the clinicopathological parameters in pancreatic cancer but only cathepsin L expression in tumor epithelium predicted a poor prognosis for the disease., Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma., Circulating MMP-2, -3 and -9 are independently associated with kidney disease progression in non-diabetic chronic kidney disease patients and add incremental predictive power to conventional risk factors., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, The study investigated CD147 and MMP-2 expression in epidermis of cutaneous squamous lesions, Dephosphorylation of MMP-2 affects the conformational structure of the enzyme., These studies provide direct evidence that targeting MMP-2 will effectively protect against collagen and occludin loss and HT after ischemia and reperfusion., osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression., AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma., The MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population., Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety., the present study provided strong evidence to suggest that the MMP-2 rs243865 C/T polymorphism may be associated with reduced risk of AS. Further studies are needed to confirm the results of this preliminary study., Letter, These observations suggest a crosstalk between monocytes and human renal mesangial cells via the interaction of MMP2 and fractalkine., MMP2/TIMP2 and MMP9/TIMP1 immunoreactivity was extremely heterogeneous within the analyzed group of secondary liver tumors., Only MMP-9 Rs3918242 (C->T) single nucleotide polymorphism was found to play a significant role in the development of AMD, and the effect was more pronounced at the age of less than 65 years., CD147 promotes melanoma progression through hypoxia-induced MMP2 activation., The present study evaluated the serum levels of specific metalloproteinases (MMP-2 and MMP-9) and investigated the gene TGFBR in 28 patients with aortic valve disease associated with ascending aortic dilatation., An association between MMP-2 and RAS cannot be ruled out but we could not find strong evidence to support it, while an association of the TIMP-1 gene with RAS was ruled out based on our results., These data indicate that amsacrine induces MMP-2/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability in human leukemia cells., MMP-2 regulates human platelet activation through hydrolysis of talin, The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable Coronary Artery Bypass Grafting outcomes, Data from model complexes of MMP-2 and triple-helix peptide fragments of COL2A1 (collagen, type II, alpha 1) suggest that the triple helix is distorted to allow the accommodation of an individual peptide chain within the MMP active site., Signal enhancement of silicon nanowire-based biosensor for detection of matrix metalloproteinase-2 using DNA-Au nanoparticle complexes., MMP2 could promote the migration and invasion of BC cells., Expression of MMP2 and MMP3 mRNA was significantly lower in NRD1-knockdown TE5 cells., MMP-2 and sLe(x) were negative prognostic markers for survival in these head and neck squamous cell carcinoma patients., Our results show that cytokines, mitogens and inducers show variable upregulation of U2OS osteosarcoma and RD rhabdomyosarcoma MMP-2 and -9 secretion., Common sequence variants and haplotype of MMP2 (-1575 G>A and -168 G>T) might be a genetic risk for the development of Metabolic Syndrome X in the North Indian population., which showed that MMP2 was higher in oral squamous cell carcinoma cancer tissues than adjacent tissues, autocrine secretion of MMP-2/9 by brain microvascular endothelial cells induced by humoral factors, other than IgG, in sera obtained from neuromyelitis optica patients potentially increases blood-brain barrier permeability, The serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects., KLF4 protein expression was inversely correlated with MMP2., Matrix metalloproteinase-2 (-1306 c>t) promoter polymorphism is associated with the risk of colorectal cancer., the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity. The present study indicates that MMPs have interactions spanning the P23-P23' subsites of collagenous substrates., The highest levels of MMP-2 and MMP-9 activities are found in the basal plate and extravillous trophoblast cells in women with undifferentiated connective tissue dysplasia., In right colon adenocarcinoma tumors, MMP2, p53, and beta-catenin gene expressions were higher than when compared to left colon., Amyloid-beta can regulate the proinflammatory state of human macrophages by inducing MMP-2/MMP-9/cathepsin S levels and by reducing TGF-beta1 secretion., Different expression of MMP-2 and MMP-9 regarding differential hormonal receptor expression could indicate distinct mechanisms of their regulation in breast neoplasms., The expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 1 (TIMP1), interleukin 6 (IL-6), and interleukin 15 (IL-15)., Higher serum MMP-2 levels and MMP-2/TIMP-2 ratio could predict poor prognosis after TACE, suggesting prognostic role of these biomarkers in HCC., The expression of protein and mRNA of MMP9 and E-cadherin following treatment with PGE2 were suppressed and increased by celecoxib, respectively; however, MMP2 showed no change in A549 cell., TIMP-2 seems to be a predictor of gastric tumor progression, especially for nodal involvement, whereas serum MMP-2 might be useful as an independent prognostic factor of patients' survival., The alphavbeta6 effect on bone loss is due to upregulation of soluble MMP2., POU5F1 enhances the invasiveness of cancer stem-like cells in lung adenocarcinoma by upregulation of MMP-2 expression., Finasteride significantly downregulated MMP2 and MMP9 activities in RWPE-1 and PC3 cells and MMP2 in DU145 cells., These data highlight a novel MT1-MMP/MMP2/RAC1 signaling axis in melanoma., results suggest that the MMP-2-1306 C/T and MMP-9-1562 C/T polymorphisms are significantly associated with bladder cancer susceptibility, and no associations were found between MMP-9-1562 C/T polymorphism and bladder cancer susceptibility, MMP-2 and TIMP-2 might play a role in the process of colorectal cancer invasion and metastasis, Id4 has a role in suppressing MMP2-mediated invasion of glioblastoma-derived cells by direct inactivation of Twist1 function, Serum and to a larger extent sputum MMP-2 appear to be potential noninvasive markers for detecting lung cancer., In acute ischemic stroke patients, MMP-2 levels are associated with the pre-existing burden of white matter hyperintensity., Elevated serum MMP2 levels in firefighters after the World Trade Center attack increase the odds of resistance to lung injury., MMP2 over-expression enhanced the MICA shedding, indicating that MMP2 was involved in the renal-cell-carcinoma-associated proteolytic release of soluble MICA, which facilitated the tumor immune escape., Matrix metalloproteinase-9 overexpression is associated with colon cancer., Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines, Thus the high MMP-2/MMP-9 ratio (> or = 1.8) may be associated with unfavorable course of AML., the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma, Expression of MMP-2 during ovarian follicular development was identified., Atherosclerotic plaques exert a prothrombotic effect by potentiating platelet activation due to their content of MMP-2; an elevated MMP-2 activity in plaques is associated with a higher rate of subsequent ischaemic cerebrovascular events., The resulting fusion protein was then used to target pancreatic cancer cells (PANC-1) in vitro. M-CTX-Fc decreased MMP-2 release into the media of PANC-1 cells in a dose-dependent manner, Spearman correlation analysis revealed that HIF-2alpha and MMP-2 expressions were significantly correlated (r = 0.990; P = 0.041)., High expression of matrix metalloproteinase 2 is associated with squamous cell carcinoma of the vulva., findings support an unrecognized interplay between ANG, ERK1/2 and MMP2 that can impact tumor growth and progression., Activation of endothelial MMP-2 by MMP-9 contained in neutrophil extracellular traps (NETs) is an important player in endothelial dysfunction. Aberrant NET formation plays pathogenic roles in systemic lupus erythematosus., Data indicate that silencing of alpha-fetoprotein led to an increased apoptosis, which was associated with a decreased expression of vascular endothelial growth factor, vascular endothelial growth factor receptor 2, matrix metalloproteinases-2/9., Concomitant increase in the expression of both MMP-2 and TIMP-2 in oral leukoplakia suggests that the activation of MMP-2 is dependent on TIMP-2 acting as a cofactor., Data suggested that IL-6 mainly promotes the cell migration and invasion of Nasopharyngeal carcinoma cells; the effect of IL-6 on cell migration and invasion may be mediated through regulation of the expression of MMP-2 and MMP-9., Icaritin suppresses the proliferation of SaOS2 human osteosarcoma cells by increasing apoptosis and downregulating MMP2/9 expression., Heterogeneity among serum MMP-2 and MMP-9 isoforms and their charge variants was found in sera of multiple sclerosis patients., The variant alleles of MMP2 -735C/T and MMP2 -1306C/T can be considered as molecular risk factors for B-NHL among Egyptians., Mutation in the matrix metalloproteinase 2 gene is associated with Torg Syndrome., Activation of Toll-like receptor-9 promotes cellular migration via up-regulating MMP-2 expression in oral squamous cell carcinoma., In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis., Evaluation of the microvessel density and the expression of MMP2 and MMP9 and TTF1 in the different subtypes of lung adenocarcinoma in Tunisia, MMP-2, MMP-9, and E-cadherin are expressed in the endometrium of infertile patients during the receptive phase of the natural menstrual cycle. However, there is no correlation between the expression of these molecules and the clinical IVF outcomes., we conclude that SOX2 promotes migration and invasion of laryngeal cancer cells by inducing MMP-2 via the PI3K/Akt/mTOR pathway, Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB., Spearman's rank tests showed that MMP-2/9 activities in cardiac tissue obtained before CPB were positively correlated with postoperative cTnT serum levels, This co-targeting strategy relies on the interaction of MMP-2 with integrin a(v)b(3), which are known to associate via the hemopexin domain of MMP-2, The possible role of MMP-9 and MMP-2 on the expression of soluble CD154 (sCD154) and membrane-bound isoform of the CD154 in Iranian multiple sclerosis patients, was examined., Poly(I, That expressed considerable amount of MMP-2 and MMP-9., probe activation for a MMP-2/9 responsive radiolabeled ACPP probe occurred already in the vasculature early after systemic administration, followed by nonspecific uptake in subcutaneous tumors that is comparable for high and low MMP-expressing tumors, Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas, Comparison of proMMP-2 and prognostic factors revealed a statistically significant correlation between proMMP-2 and age in patients with histologic grade I tumors for invasive ductal breast cancer., By reducing MMP-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways., expression of stromal MMP-2 alone, as well as coexpression of stromal MMP-2 with tumoural MMP-2 or -9, correlates significantly with prognostic predictors in breast cancer patients, data suggested that cellular cholesterol regulated ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell., expression of MMP-2 and MMP-9 proteins increased with the degree of extra-gastrointestinal stromal tumor metastasis risk., CGP may inhibit migration and invasion in HT1080 cells through the urokinase plasminogen activator (uPA)-uPA receptor signaling pathways to inhibit MMP-2 and MMP-9., MMP-2 gene expression was significantly increased in the secondhand smoke and active smoking groups, Study shows that beta3GnT8 is involved in the regulation of CD147 N-glycosylation and further influences MMP-2 expression in tumor cells suggesting that it may play an important role in the CD147 signaling as an upstream modulator of MMP-2 in tumor cells., local levels of MMP-2, an important factor for AAA development, were increased in current smoking AAA patients., Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in squamous cell and basal cell skin neoplasms., upregulation of MMP-2 and MMP-9 and downregulation of TIMP-1, is one of the mechanisms by which Skp2 promotes cell invasion of human renal cancer cells, The extracellular domain of soluble CD147 enhances the secretion of MMP-2 from hepatocellular carcinoma cells., MMP-2 -1306C>T polymorphism is not associated with breast cancer susceptibility., MMP2 polymorphisms are associated with colorectal cancer susceptibility., UV radiation emitted by the solar simulator was able to stimulate the cells from extracellular matrix in in vitro culture to TGF-beta production, MMP-2 and MMP-9 expressions and their mRNAs., Letter, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experiments., naringenin is capable of inhibiting bladder cancer cell migration through the downregulation of the AKT and MMP2 pathways, The MMP-2 levels in the fertilized oocyte group(208.2 +/- 31.6 ng/mL) were higher than those in the nonfertilized oocyte group, our finding suggests that both MMP-2 and MMP-9 expressed by synoviocytes as well as certain infiltrating immune cells role figure importantly in the angiogenesis in rheumatoid arthritis progression., Spinal cord injury patients who were physically active had lower plasma levels of MMP2., MMP-2 degraded Titin fragment in serum is related to induction of skeletal muscle atrophy., Overexpression of MMP2 is associated with ameloblastoma., Serum matrix metallopeptidase 2 was identified as relevant baseline biomarker of Sunitinib activity in advanced Renal Cell Carcinoma., Data indicate that the mRNA and protein expressions of extracellular signal-regulated kinase 1/2 (ERK1/2) and and matrix metalloproteinases MMP-2 and MMP-9 were significantly decreased by baicalein., MMP-2 level was significantly lower in patients with bone tumors than in controls., STAT3 and MMP-2 have a role in the diagnosis of colon adenocarcinoma and the detection of the degree of differentiation, a-Solanine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), High MMP2 protein expression is associated with pancreatic ductal adenocarcinoma., PPARdelta-mediated modulation of MMP-2 secretion and elastin expression may contribute to the maintenance of skin integrity by inhibiting ROS generation, Ectopic expression of MMP2 rescued miR-130b-suppressed cell migration and invasion., The present study suggested EGCG at nontoxic levels could inhibit migration of melanoma cells via downregulation of activities of secreted MMP-2 through the inhibition of the ERK1/2 phosphorylation, Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation., The results indicated that SNS and EGCG caused a dose-dependent decline in the activity, transcription and translation of MMP-2 after treatment with SNS and EGCG, while AA was only able to inhibit the activity at maximum doses, HP1b negatively regulates MMP2 expression in a transcriptional level and prevents MMP2 activation through reducing the expression of MT1MMP., Taken together, our findings suggest that AEG-1 plays a crucial role in the aggressiveness of osteosarcoma via the JNK/c-Jun/MMP-2 pathway., fibronectin was able to induce MMP2 expression by 30% decrease in its promoter methylation, EGF aids in the production of MMP-2, which favors the dissolution of the basement membrane, contributing to cell migration and tumor progression., found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, Data suggest that intracellular S100A8/A9 contributes to the cancer cell phenotype by modulating matrix metallopeptidase 2 (MMP-2) expression and activity to regulate cell migration and mobility., G-CSF increases MMP-2 activity and VEGF secretion in Swan 71 cells (trophoblasts) through activation of PI3K/Akt and Erk signaling pathways., upregulation of MMP2 rescued the decreased migration and invasion induced by the knockdown of Rock2, whereas the knockdown of MMP2 decreased Rock2-enhanced hepatocellular carcinoma migration and invasion, The authors' results support the importance of MMPs and their tissue inhibitors in meningioma pathogenesis., The roles of MMP-2 in cardiac injury and repair. [Review], the proliferation of HBSMCs induced by stretch was resulted from the stretch-induced MMPs expression and release., These results suggested that PFIO could suppress the invasion and migration of human lung carcinoma by reducing the expression levels and activity of MMP-2 and MMP-9 via suppression of MAPKs, PI3K/AKT, and NF-kappaB signaling pathways., Data indicate matrix metalloproteinase 2 (MMP2) homozygous missense mutation in exon 8 c.1228G>C (p.G410R)., TIMP-2 -418 GC + CC and MMP-2 -1575GA/-1306CC genotypes could be genetic predisposing factors for moyamoya development., MMP-2, MMP-9, MMP-7 and TIMP-2 were upregulated in primary spontaneous pneumothorax lesions., In cases of preeclampsia, the least expression of MMP-2 and MMP-9 is recorded in IC and MGCs in the complete absence of intravascular cytotrophoblast, MMP-2 expression correlates with tumor thickness in melanoma and is an independent predictive factor for lymph node involvement., High serum and tissue levels of MMP2 were associated with lymph node metastasis and tumor staging in breast cancer., LOX may play a role in the metastasis of non-small cell lung cancer by promoting MMP2/MMP9 expression., MMP-2 is increased and TIMP-1 decreased in thoracic aortic aneurysms with bicuspid aortic valve., The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation., resistin promotes chondrosarcoma metastasis and MMP-2 expression through activation of the AMPK/p38 signaling pathway and down-regulation of miR-519d expression, we concluded that NCTD enhances TIMP2 antitumor and antiVM activities in gallbladder cancers through downregulating MMP2 and MT1MMP., Stat3, phosphorylated Stat3, and MMP2 were overexpressed in esophageal squamous cell carcinoma (ESCC) and associated with invasion of ESCC. Stat3 up-regulated expression of MMP2 in ESCC through directly binding to the MMP2 promoter., The MMP-2/TIMP-2 expression ratio has a higher prognostic value than the separate expressions of MMP-2 and TIMP-2., MMP-2, MMP-9, TIMP-1, and TIMP-2 may have important roles in the development and progression of MFH., VEGF-alpha, MMP-2 and MMP-9 may play a role in colorectal tumorigenesis, Results demonstrated that the p38 MAP kinase signaling pathway is essential for MMP-9 but not MMP-2 upregulation in pericytes in response to TGF-beta1 stimulation, MMP-2 polarizes T cells toward type 2 responses in vivo, in a TLR2-dependent manner., a possible coordinated role of VEGF-A and MMP-2 during uterine leiomyomas growth and angiogenesis with potential prognostic significance, MMP-2 -1306C>T polymorphism is associated with primary ovarian insufficiency in Korean women. Lower serum E2 levels were detected in healthy women with the MMP-2 -1575GA+AA/MMP-2 -1306CT+TT and MMP-2 -1306CT+TT/MMP-9 2678GG combination genotypes., Cleaved CD147 plays a pivotal role in stimulating fibroblasts to induce Matrix Metalloproteinase 2 activity., Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak2 and Stat3 pathway, Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9, we found that miR-373 and -520c down-regulated the activities of MMP2 in various cancer cell lines but simultaneously up-regulated the expression of MMP9 gene only in HT1080 cells, In prostate cancer cells, alphavBeta6 is required for upregulation of MMP2., Upregulation of EZH2, MMP2 and TIMP2 expression was correlated with metastasis of RCC to bone tissues ex vivo and in vitro., MMP-2 is necessary for fibronectin matrix disruption and dispersal of human fibroblast cell clusters., WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential., the most significant MMP-2...fTHP-5 interactions at the catalytic and noncatalytic domains are also analyzed to gather some clues about the role of the different domains during collagenolysis., Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of MMP-2 and subsequent metastatic ability in human osteosarcomas., Cyclic stretch significantly induced ESC secretion of CXCL8 and CXCL1 and neutrophil chemotaxis. Stretch also increased MMP-1, MMP-2, and MMP-3 activity, activin A secretion, and activity in ESC., High MMP2 expression is associated with lung cancer., IHC staining showed higher TR4 level, more macrophage infiltration, lower TIMP-1 and stronger MMP2/MMP9 in tumor tissues., Ara-C enhances the invasiveness of gastric cancer cells by expression of CD-147 /MMP-2 and MMP-9 via the ERK signaling pathway., these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases, Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2., Increased Pak4 expression can lead to development of adenomyosis by enhancing the invasiveness of endometrial cells through regulation of MMP-2 and -9 activities., inhibiting heat shock transcription factor 1, which links temperature and peripheral clock-gene oscillations, inhibited MMP-9 but not MMP-2 temperature-driven MMP cycling., Our results suggest that the presence of the variant allele in the promoter of MMP-2 or TIMP-2 may be a protective factor for the development of breast cancer., The expression level of GOLPH3 is correlated with metastasis and prognosis in NSCLC, and GOLPH3 mediates metastasis by regulating the protein levels of MMP-2 and MMP-9 in vitro., TIMP1 downregulates MMP-2 activity and inhibits the degradation of occluding in Caco-2 intestinal cells, Data suggest that changes in DNA methylation in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4), and (3) matrix metalloproteinase (MMP2 and MMP9) activity., Data indicate that the enzymatic activity of MMP-2 and MMP-9 on dystroglycan plays a significant role in muscular dystrophies and also in physiological processes taking place in the central and peripheral nervous system. [review], ENaC could mediate trophoblast cells invasion ability through regulating expression and activity of matrix metalloproteinase-2., AR knockdown led to substantial reductions in matrix metalloproteinase 2 (MMP2) and p-AKT levels in Esophageal squamous cell carcinoma cell lines, but no significant change in AKT and MMP9 expression, High MMP2 expression is associated with invasion and promotion of metastasis in melanoma., MMP-2 -735 C allele is a risk factor for breast cancer., Matrix metalloproteinase-2 -1306 C>T gene polymorphism is associated with reduced risk of cancer., To examine the relationships among BAG3, miR-29b and MMP2 in endometrioid adenocarcinoma cells., High serum mmp2 levels are associated with Squamous cell carcinoma., Reactive oxygen species increase the activity/levels of gelatinolytic matrix metalloproteinases, and stimulate cytokine secretion in human periodontal ligament fibroblast., MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA., our findings suggested that the differential expression of MMP-2 and TFPI-2 have a negative correlation in pancreatic carcinoma, japonicus was able to inhibit the expression of MMP-2 and MMP-9 and suppress the transcription and translocation of iNOS and COX-2 by directly inhibiting the activation of NF-kappaB and the phosphorylation of the MAPK pathway, There was no association between the expression of metallopeptidase-2 or tissue inhibitor of metalloprotease 2 and death or progression, MMP-2 is a direct target of miR-519d-3p., A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M., MMP-2 protein and ECM1 gene are useful preoperative markers for defining malignancy in suspicious thyroid nodules, Results showed that expression of MMP-2 was associated with poor survival and lymph node metastasis. [meta-analysis], western blot analysis showed that ophiopogonin-D inhibited the expression and secretion of matrix metalloproteinase-9 (MMP-9), but not that of MMP-2., For gingiva samples from chronic periodontitis patients treated with antibiotics, MMP-2 positive reaction was restricted to deep epithelial layers and few cells of the connective tissue. No significant difference was observed for TIMP-2 expression., Neutralization of MMP activity by antibodies to MMP2/9, broad-spectrum MMP inhibitor or selective gelatinase inhibitor resulted in significant suppression of HGF-induced EMT and cell migration/invasion., D90 significantly inhibited the invasion and metastasis of OSCC cells by decreasing the expression of sp1 and increasing the expression of RECK to suppress the expression and activity of MMP-2 and MMP-9., recombinant human (rh) MMP-2 and MMP-9 were incubated with Abeta40 and Abeta42, and the resulting proteolytic fragments were assessed via immunoprecipitation and quantitative mass spectrometry, Results show that low levels of MMP-2 expression in gastric tumor and stromal compartments were significantly associated with poor prognosis., MMP2 -1306 TT carriers had a decreased incidence of esophageal cancer., Results indicate that VEGFR2 -906, COX-2 -1195 and MMP-2 -1306 variants and their combinations may signi fi cantly in fl uence clinical outcome in inoperable non-small cell lung cancer patients treated with radiotherapy with or without chemotherapy., EFEMP1 might indirectly enhance the expression of MMP-2, providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB pathways might be one of the effective ways which EFEMP1 was induced by AEG-1., type 2 diabetes (T2DM) patients carrying the T allele of MMP-2 C(-1306)T polymorphism have a significantly reduced risk of cardiovascular disease; the C(-1306)T polymorphism is associated with susceptibility to stroke in T2DM patients, PinX1 negatively regulated ccRCC metastasis and the expression of MMP-2 and NF-kappaB-p65, High MMP2 expression is associated with renal fibrosis in lupus nephritis., both populations exert distinct proteolytic activities, being the IL-10-stimulated macrophages the most efficient in inducing matrix metalloprotease (MMP)-2 and MMP-9 activities., PM10 from commercial zone up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/beta-catenin expression after 48 h of exposure., data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages, Tissue array analysis suggests role for MMP2 in regulating the occurrence of glioma and disease progression., Results demonstrate that miR-29b serves as a tumor metastasis suppressor, which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression., In asthma, MMP-1 and MMP-2 mediate IL-13-induced suppression of ELN expression in airway fibroblasts., MMP2 was correlated with diastolic dysfunction in new-onset heart failure outpatients., Lipid raft-associated processes, such as PP2A and MMP-2 activation, participate in PCB153-induced disruption of occludin function in brain endothelial barrier., results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha, Both MMP9 rs3918242 and MMP2 rs243865 are associated with risk of NAFLD., MMP-2 expression was higher in retinoblastoma than in normal retina; undifferentiated tissues had higher positive expression than differentiated tissues (not statistically significant); higher positive expression was detected in invasive optic nerves., According to this work it seems likely that product release is the rate-limiting step in MMP-2 catalysis., Treatment with propofol efficiently reduced MMP2 protein expression levels, and overexpression of miR218 also decreased MMP2 protein expression levels., SFN inhibited invasion by activating ERK1/2 to upregulate E-cadherin and downregulate CD44v6, thereby reducing MMP-2 expression and activity. E-cadherin is an invasion inhibitor, while CD44v6 and MMP-2 are invasion promoters, MMP2 mRNA is degraded in pancreatic tumor cells following treatment with PP2A inhibitors., The results suggest that AQP1 may facilitate lung cancer cell proliferation and migration in an MMP-2 and-9-dependent manner., The findings of this study suggested that the MMP-2-1306 T/C polymorphism is a direct risk factor for ischemic leukoaraiosis., MMP-2 plays an essential role in leptin-induced migration and invasion. Leptin increased the mRNA and protein expression and enzyme activity of MMP-2 in 11Z and 12Z endometriotic cells by an ObR-dependent JAK2/STAT3 signaling pathway., Metformin suppressed OS MG63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (MMP2) and MMP9, the results showed that Dicer protein ablation leads to increased cell invasion, higher levels of matrix metalloproteinase-2, and decreased levels of key miRNAs shown to inhibit invasion, we report the novel concept that miR-20b exerts a suppressive effect on both cell cycle-modulated proliferation and MMP-2-mediated migration and invasion in bladder cancer EJ cells., These results indicate that our hydrophilic extract from P. oceanica might be a source of new pharmacological natural products for treatment or prevention of several diseases related to an altered MMP-2 and MMP-9 expression., E6-HPV16/E7-HPV16 promoted the activity of MT1-MMP and MMP-2/9, contributing to the migration of cervical cells and neoplasm invasiveness., A positive association for VEGF-D and an inverse association for MMP-2 were observed in patients with positive lymph node status at the time of radical cystectomy in urothelial carcinoma of the bladder., Plasma MMP-2 level may be a useful diagnostic marker for monitoring hepatic fibrogenesis in patients with disease of different aetiologies., WM130 could inhibit cell proliferation, invasion, migration and induced apoptosis in HCC cells by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways., Findings suggested that MMP-9 and MMP-2 overexpression might indicate a higher risk of poor prognosis in breast cancer. [meta-analysis], This study demonstrated that the MMP-2 -1575G/A polymorphism led to a 5-year-earlier age of disease onset in MS patients with ON as a first symptom (p=0.009)., PPARgamma activation can activate PTEN expression, thereby suppressing the expression of MMP2 and hence inhibiting the invasion and metastasis of pancreatic cancer cells., For the MMP2 -1306 C/T polymorphism, there was a negative association with the T allele for bladder cancer in the Asian population, In summary, our results showed that negative HCRP-1 expression is an independent prognostic factor for RCC patients., Data suggest that activin A up-regulates SNAIL expression via ALK4/ACVR1B-induced SMAD signaling in trophoblast cells; elevated SNAIL contributes to up-regulation of MMP2 expression which plays key role in promoting trophoblast cell invasion., Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications., There is no significant difference between different genotypes of matrix metalloproteinase 2 polymorphism and risk of developing Prostate Cancer, The level of MMP-2 in follicular fluid was a reliable marker of oocyte maturation in in vitro fertilization., two distinct MMP-2 isoforms are associated with tubular injury in delayed kidney graft function, Data show that higher plasma levels of matrixmetalloproteinases 2/9 (MMP-2/MMP-9), osteopontin (OPN) and interleukin-6 (IL-6) were observed in Non-Hodgkin lymphomas (NHL) patients compared to controls., The inhibitory effect of nuclear HDAC6 on invasion of NSCLC was mediated by the deacetylation of the p65 subunit of nuclear factor-kappaB, which decreased its DNA-binding activity to the MMP2 promoter, leading to the downregulation of MMP2 expression., An important role of MMP2 in connective tissue remodeling (proteolytic degradation) during the early period of postinfarction reparative regeneration., The highest number of strong immunoreactivity to MMP-2 in the ameloblast region was found in the plexiform variant., Intensive vascular networks formed by HUVECs were associated with hAMSCs or BMMSCs and related to MMP2 and MMP9., PKD2 is a core factor in the formation of this multiprotein complex at the TGN that controls constitutive secretion of matrix metalloproteinase cargo., Data show that evodiamine significantly decreased mRNA and protein levels of matrix metallopeptidase 2 (MMP-2) in the nasopharyngeal carcinoma (NPC) cells, but had little effects on matrix metallopeptidase 9 (MMP-9) mRNA and protein levels., data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB-dependent upregulation of MMP-9 and MMP-2, showed a significant association between the variants of MMP-2 and TIMP-2 promoters and spontaneous intracerebral hemorrhage, the serum levels of MMP-2 and MMP-9 proteins were higher in patients with OA than in controls, while MMP-1 and MMP-9 protein expressions were higher in the synovial joint fluid of patients with osteoarthritis than in controls., This study showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of cardiovascular diseases (CVDs) suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs., targeting EGFR signaling and its downstream molecules contributed to the inhibition of EGFinduced HT29 cell metastasis caused by tetrandrine, eventually leading to a reduction in the mRNA and gelatinase activities of MMP-2 and MMP-9, The blocking of either intracellular ROS or ERK pathway caused the downregulation of MMP-9 and MMP-2 expression., Expression of MMP2 and MMP7 in gastric cancer is not associated with mTOR, MMP9 expression might be related to mTOR signalling in a subset of tumors, The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9., Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells., MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population., The abundance of mutated STIM1 and the MMP-2 expression were higher in native human umbilical vein endothelial cells of patients with gestational hypertension than controls and were significantly correlated with blood pressure., renal cell carcinoma patients with a high MMP-2 expression level exhibit rapid progression of renal cell carcinoma and that high MMP-2 expression level is associated with poor prognosis, TIMP3 was validated as a direct target of miRNA-21 by dual-luciferase reporter assay. Silencing with small interfering RNA against TIMP3 promoted angiogenesis and increased MMP2 and MMP9 expression at the protein level., determined normal concentration ranges for MMP-1, MMP-2, MMP-9, TIMP-1, and ratios of concentrations of MMPs and TIMP-1 (MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-9/TIMP-1) in the amniotic fluid at the first period of labor in physiological pregnancy., The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 and MMP-9 and in some cases the enhanced activity of uPA and ACE, which makes an additional contribution to the increased invasive potential of tumor, MMP2 variants are associated with rheumatoid arthritis in women., Data show that spider venom sphingomyelinase D increased expression/secretion of MMP2, MMP9 and MMP7 which was associated with keratinocyte cell death., Overexpression of MMP2 and EGFR were independent risk factors for mortality in non-small cell lung cancer patients.,
OFFICIAL_GENE_SYMBOL MMP2,
OMIM_DISEASE Multicentric osteolysis, nodulosis, and arthropathy,
SP_COMMENT catalytic activity:Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 4 calcium ions per subunit., disease:Defects in MMP2 are the cause of Torg-Winchester syndrome [MIM:259600]; also called multicentric osteolysis nodulosis and arthropathy (MONA). Torg-Winchester syndrome is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5)., function:In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond., PTM:The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3)., similarity:Belongs to the peptidase M10A family., similarity:Contains 3 fibronectin type-II domains., similarity:Contains 4 hemopexin-like domains., subunit:Ligand for integrin alpha-V/beta-3., tissue specificity:Produced by normal skin fibroblasts.,