Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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microRNA 10b(MIR10B) microRNA 10b(MIR10B) Related Genes Homo sapiens
CYTOBAND 2q31.1,
GENERIF_SUMMARY microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion, MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC., Identified the effect of post-transcriptional regulation of miRNA-10b on PPAR-alpha expression to influence steatosis level in hepatocytes, which may contribute to pathogenesis of non-alcoholic fatty liver disease., elevated expression of miR-10b in 95% (38 of 40) of esophageal cancer tissues, although no significant correlation of the miR-10b level with clinical metastasis status was observed in these samples, Data show that NF1 mRNA was the target for miR-10b., miR-10b positively regulates the metastasis of nasopharyngeal carcinoma (NPC)., Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion., changes in miR-10a and -10b expression levels may regulate SFRS1-dependent alternative splicing and translational functions., The miR-10b has major roles in the process of neural cell differentiation through direct targeting of NCOR2, which in turn induces a cascade of primary and secondary transcriptional alterations., Data show that Argonaute 2 expression is critical for stem cells to escape senescence by downregulating miR10b and miR23b, and that selenoprotein N1 is also involved in ATSC survival and self-renewal through ROS-mediated p38 MAPK inactivation., miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10, microRNA-10b has a role in glioma, report that the microRNA-10b gene (miR-10b) was silenced in gastric cancer cells by promoter methylation, heparin attenuates miR-10b expression and induces HoxD10 expression in vivo to inhibit angiogenesis and impair the growth of MDA-MB-231 tumor xenografts, in 10 pancreatic ductal adenocarcinoma (PDAC) samples, miR-10b was the most frequently overexpressed miRNA exhibiting a 4-fold increase in cancer cells; lower levels were associated with improved response to multimodality neoadjuvant therapy and survival, We experimentally validated the role of one of the dysregulated miRNAs (miR-10b) in relapse using proliferation and wound-healing assay., MIR-10b is overexpressed in pancreatic cancer and may be involved in the invasiveness in pancreatic cancer cells, thereby leading to a poor prognosis., WISP-2 regulates microRNA-10b via hypoxia-inducible factor-1alpha-TWIST signaling networks in human breast cancer cells., miR-10b showed higher expression levels in tumors obtained from bilateral breast carcinoma patients as compared to unilateral neoplasms., Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors., miR-10b actively participates in cancer formation by promoting cell migration and invasion, We have demonstrated that high expression of miR-10b is associated with enhanced malignant potential and poor prognosis in human colorectal cancer. In vitro studies revealed that miR-10b expression is associated with chemoresistance to 5-fluorouracil., miR-10b may positively regulate the invasion and metastasis of HCC through targeting CADM1., Rho-GTPase-dependent modulation of cytoskeletal function and downregulation of E-cadherin expression are identified as relevant effectors of the miR-10b-syndecan-1 axis, Treatment after the formation of lymph node metastases arrests the metastatic process without a concomitant effect on primary tumor growth raising the possibility of a context-dependent variation in miR-10b breast oncogenesis, we found that both miR-10b and miR-196b show elevated expression in human high-grade breast tumor vasculature, These findings indicate the existence of a novel E-cadherin-related mechanism by which miR-10b modulates breast cancer metastasis., our results define MICB as a novel immune target of miR-10b, TWIST-1 and miR10a/b expression are dysregulated in MDS. Expression of miRs10a/b is controlled by TWIST-1., The pleiotropic nature of miRNA-10b was due to its suppression of multiple tumor suppressors, including TP53, FOXO3, CYLD, PAX6, PTCH1, HOXD10 and NOTCH1., Ectopic delivery of microRNA-10b* in breast cancer cell lines or into xenograft mouse breast tumours inhibits cell proliferation and impairs tumour growth., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., study observed that circulating miR-10b and miR-373 levels could distinguish breast cancer patients with lymph node metastasis from non-metastatic patients, High miR-10b levels are associated with glioblastoma., In humans, miR-10b may play an important role in progression and prognosis of gastric cancer., MiR-10b is highly upregulated in metastatic minimally invasive follicular thyroid carcinoma., downregulation of HOXD10 expression by miR-10b overexpression may induce an increase of pro-metastatic gene products, such as MMP14 and RHOC, and contribute to the acquisition of metastatic phenotypes in epithelial ovarian cancer cells, The miR-10b locus and its involvement in cancer, focusing on its role in the establishment and spreading of breast cancer. [Review], Identification of a possible link between miR-10b expression in metastasis and patient survival., miR-10b promotes pancreatic cancer cell proliferation and invasion by suppressing TIP30., TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN., High levels of miR-10b expression promotes migration and invasion in nasopharyngeal carcinoma., MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration., This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs., Inhibition of miR-10b expression partially reversed the epithelial-mesenchymal transition, invasion and proliferation induced by TGF-beta1 in breast cancer cells., miR-10b functions as a novel tumor suppressor and is partially silenced by DNA hypermethylation in gastric cancer., miR-10b may function as oncogenes in bladder cancer cells, miR-10b inhibits TBX5 expression at the level of translation. Higher levels of miR-10b expression are associated with a higher risk of congenital heart defects., miR-10b, is a negative regulator of the CYP11B1 and CYP11B2., miR(21/10b) ratio is an independent prognostic factor for clear cell renal cell carcinoma, which could be useful to identify high-risk patients who could benefit from increased surveillance., found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b, miR-520d-5p targeting of TWIST1 resulted in reduced expression of the prominent metastamiR miR-10b, MiR-10b is highly expressed in metastatic breast cancer MDA-MB-231 cells., High-expression of microRNA-10b is asociated with cancer., we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets., This study reports the first evidence of miR-10b over-expression in NPC patients. Furthermore, our findings can support hsa-miR-10b gene regulation through LMP1/Twist1 in NPC malignancy, miR10b is potentially involved in the invasion of colorectal cancer., miR-10b contributed to abnormal vascular smooth muscle cell proliferation through inhibiting the Akt pathway by targeting TIP30 in atherosclerosis, Downregulation of miR-10b directly derepresses the expression of BCL2L11, an apoptosis inducer., Inhibition of miR-10b represses E2F1-mediated transcription, leading to down-regulation of multiple E2F1 target genes and stalling progression through the S-phase of cell cycle., these findings offer convincing evidence that increased miR-10b expression may be an independent marker to predict poor prognosis in patients with gliomas., MiRNA-10b expression levels in PBMCs can distinguish nonsmall-cell lung cancer (NSCLC) patients from cancer-free subjects , suggesting that miRNA-10b expression in PBMCs is a valuable diagnostic and prognostic marker in NSCLC, MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin., miR-10b-5p has a role in Huntington's disease brain related to age of onset and extent of striatal involvement, MiR-10b directly targets the 3'-UTRs of ZEB1 and PIK3CA., Silencing of miR-10b inhibited cancer cell progress by arresting cell cycle progression in the G0/G1 phase and promoted apoptosis non-small cell lung cancer cells., miR-10b was upregulated in gastric carcinoma and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4., Results show that overexpression of miR10b in ER-positive breast cancer cell lines led to increased resistance to tamoxifen and HDAC4 was identified as its direct target. MiR10b-HDAC4 nexus may be one of the molecular mechanism of tamoxifen resistance., Data suggest that microRNAs miR-10b, 21, 200c, 373 and 520c may control both metastasis and stemness potential., The expression levels of miR10b and miR135b are higher in semen with strong tissue specificity., Inhibition of miRNA-10b abrogated the colony-forming capability of medulloblastoma cells, and markedly down-regulated the expression of BCL2. Down-regulation of BCL2 by antisense oligonucleotides or siRNA also significantly down-regulated miRNA-10b., Enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis., matrix metalloproteinase 1 (MMP1) may be involved in the miR10b/BDNFmediated chondrosarcoma cell migration and invasion in JJ012 cells., Results suggest that miR-10b demethylation plays a tumor-suppressive role in renal cell carcinoma.,