Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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microRNA 10a(MIR10A) microRNA 10a(MIR10A) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q21.32,
ENSEMBL_GENE_ID ENSG00000257178,
GENERIF_SUMMARY miRNA 17-5p, 20a and 126 are constitutively expressed in Ph(-) MPN megakaryopoiesis while low or absent miRNA 10a appeared to correlate with strong megakaryocytic HOXA1 protein expression, down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of chronic myeloid leukemia implicating a miRNA in its abnormal behavior, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts; in addition, members of the miR-10 family are de-regulated in several cancer forms, MiR-10a is associated with the process of HOXA 1-mediated transformation., Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer., expressed altered in esophageal squamous cell carcinoma, changes in miR-10a and -10b expression levels may regulate SFRS1-dependent alternative splicing and translational functions., The miR-10a has major roles in the process of neural cell differentiation through direct targeting of NCOR2, which in turn induces a cascade of primary and secondary transcriptional alterations., miR-10a is specifically upregulated in nucleophosmin 1 (NPM1) mutant AML bone marrow. A robust negative relationship exists between miR-10a overexpression & MDM4 downregulation., This study provides, for the first time, in vitro evidence of a pro-survival role of miR-10a in NPM1mut-AML, that it may contribute to the pathogenesis of NPM1 mutated (NPM1mut)-AML and identifies putative tumorogenic targets., MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness., miR-10a expression is upregulated in cervical cancer tissues, and miR-10a promotes cell growth, migration and invasion by targeting CHL1 in human cervical cancer cells., Data show that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in umbilical venous endothelial cells inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling., miR-10a expression is downregulated in hepatocellular carcinoma compared to non-tumor tissue., TWIST-1 and miR10a/b expression are dysregulated in MDS. Expression of miRs10a/b is controlled by TWIST-1., miR-10a can promote hepatocellular carcinoma (HCC) migration and invasion in vitro but suppresses the metastasis of HCC in vivo, microRNA-10a and microRNA-30d have roles in kidney injury, Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting., MiR-375 and miR-10a were overexpressed in medullary thyroid carcinoma., MiR-10a restores the differentiation capability of aged hMSCs through repression of KLF4., In conclusion, our studies in multiple bladder cancer cell lines and primary non-malignant urothelial cells suggest that hypermethylation of miR-152, miR-10a and miR-200b regulative DNA sequences might serve as epigenetic bladder cancer biomarkers., miR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen., TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN., miR-10a was up-regulated during endodermal differentiation of PMSCs and involved in its differentiation partially via the suppression of the Hoxa1 gene, This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs., miR-10a acts as a tumor suppressor in GC cells and is partially silenced by DNA hypermethylation in GC, suggesting that miR-10a may serve as a potential diagnostic or therapeutic target of GC., MicroRNA-10a has a role in controlling airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway, miR-10a inhibits TBX5 expression at the level of translation. Higher levels of miR-10a expression are associated with a higher risk of congenital heart defects., miR-10a is overexpressed in cervical tumor tissues with lymph node metastasis, and miR-10a may significantly enhance the migration and invasion capacities of cervical cancer cells by inhibiting PTEN at the transcriptional level., Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b, In heavy alcohol drinkers, MIR10A expression was upregulated in blood following psychological stress but not in moderate drinkers., we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression, Human fetal hypoplastic congenital diaphragmatic hernia (CDH) lungs have a specific miR-200/miR-10a signature., MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway, Therefore, the expression of ADAR1 and ADAR2 was analyzed in chordoma tissues. It was found that ADAR1 was significantly overexpressed, which was accompanied by enhanced pre-miR-10a and pri-miR-125a A-to-I editing, Human miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect glioma cell migration and invasion., MIR10A plays a potential tumour suppressor role in human breast cancer., MiRNA-10a is upregulated in non-small cell lung carcinoma and activates PTEN/AKT/ERK pathway., miR-10 is specifically expressed in the developing human hindbrain and spinal cord, and regulates a large number of genes enriched for functions including transcription, actin cytoskeleton and ephrin receptor signaling., MicroRNA assays are shown to have great potential to be accurate and noninvasive methods for ESCC screening. In this study, we selected 3 microRNAs, miR-10b, miR-29c, and miR-205, to assess their diagnostic value in ESCC screening.,
OFFICIAL_GENE_SYMBOL mir10a,
microRNA 10b(MIR10B) microRNA 10b(MIR10B) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q31.1,
ENSEMBL_GENE_ID ENSG00000207744,
GENERIF_SUMMARY microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion, MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC., Identified the effect of post-transcriptional regulation of miRNA-10b on PPAR-alpha expression to influence steatosis level in hepatocytes, which may contribute to pathogenesis of non-alcoholic fatty liver disease., elevated expression of miR-10b in 95% (38 of 40) of esophageal cancer tissues, although no significant correlation of the miR-10b level with clinical metastasis status was observed in these samples, Data show that NF1 mRNA was the target for miR-10b., miR-10b positively regulates the metastasis of nasopharyngeal carcinoma (NPC)., Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion., changes in miR-10a and -10b expression levels may regulate SFRS1-dependent alternative splicing and translational functions., The miR-10b has major roles in the process of neural cell differentiation through direct targeting of NCOR2, which in turn induces a cascade of primary and secondary transcriptional alterations., Data show that Argonaute 2 expression is critical for stem cells to escape senescence by downregulating miR10b and miR23b, and that selenoprotein N1 is also involved in ATSC survival and self-renewal through ROS-mediated p38 MAPK inactivation., miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10, microRNA-10b has a role in glioma, report that the microRNA-10b gene (miR-10b) was silenced in gastric cancer cells by promoter methylation, heparin attenuates miR-10b expression and induces HoxD10 expression in vivo to inhibit angiogenesis and impair the growth of MDA-MB-231 tumor xenografts, in 10 pancreatic ductal adenocarcinoma (PDAC) samples, miR-10b was the most frequently overexpressed miRNA exhibiting a 4-fold increase in cancer cells; lower levels were associated with improved response to multimodality neoadjuvant therapy and survival, We experimentally validated the role of one of the dysregulated miRNAs (miR-10b) in relapse using proliferation and wound-healing assay., MIR-10b is overexpressed in pancreatic cancer and may be involved in the invasiveness in pancreatic cancer cells, thereby leading to a poor prognosis., WISP-2 regulates microRNA-10b via hypoxia-inducible factor-1alpha-TWIST signaling networks in human breast cancer cells., miR-10b showed higher expression levels in tumors obtained from bilateral breast carcinoma patients as compared to unilateral neoplasms., Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors., miR-10b actively participates in cancer formation by promoting cell migration and invasion, We have demonstrated that high expression of miR-10b is associated with enhanced malignant potential and poor prognosis in human colorectal cancer. In vitro studies revealed that miR-10b expression is associated with chemoresistance to 5-fluorouracil., miR-10b may positively regulate the invasion and metastasis of HCC through targeting CADM1., Rho-GTPase-dependent modulation of cytoskeletal function and downregulation of E-cadherin expression are identified as relevant effectors of the miR-10b-syndecan-1 axis, Treatment after the formation of lymph node metastases arrests the metastatic process without a concomitant effect on primary tumor growth raising the possibility of a context-dependent variation in miR-10b breast oncogenesis, we found that both miR-10b and miR-196b show elevated expression in human high-grade breast tumor vasculature, These findings indicate the existence of a novel E-cadherin-related mechanism by which miR-10b modulates breast cancer metastasis., our results define MICB as a novel immune target of miR-10b, TWIST-1 and miR10a/b expression are dysregulated in MDS. Expression of miRs10a/b is controlled by TWIST-1., The pleiotropic nature of miRNA-10b was due to its suppression of multiple tumor suppressors, including TP53, FOXO3, CYLD, PAX6, PTCH1, HOXD10 and NOTCH1., Ectopic delivery of microRNA-10b* in breast cancer cell lines or into xenograft mouse breast tumours inhibits cell proliferation and impairs tumour growth., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., study observed that circulating miR-10b and miR-373 levels could distinguish breast cancer patients with lymph node metastasis from non-metastatic patients, High miR-10b levels are associated with glioblastoma., In humans, miR-10b may play an important role in progression and prognosis of gastric cancer., MiR-10b is highly upregulated in metastatic minimally invasive follicular thyroid carcinoma., downregulation of HOXD10 expression by miR-10b overexpression may induce an increase of pro-metastatic gene products, such as MMP14 and RHOC, and contribute to the acquisition of metastatic phenotypes in epithelial ovarian cancer cells, The miR-10b locus and its involvement in cancer, focusing on its role in the establishment and spreading of breast cancer. [Review], Identification of a possible link between miR-10b expression in metastasis and patient survival., miR-10b promotes pancreatic cancer cell proliferation and invasion by suppressing TIP30., TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN., High levels of miR-10b expression promotes migration and invasion in nasopharyngeal carcinoma., MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration., This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs., Inhibition of miR-10b expression partially reversed the epithelial-mesenchymal transition, invasion and proliferation induced by TGF-beta1 in breast cancer cells., miR-10b functions as a novel tumor suppressor and is partially silenced by DNA hypermethylation in gastric cancer., miR-10b may function as oncogenes in bladder cancer cells, miR-10b inhibits TBX5 expression at the level of translation. Higher levels of miR-10b expression are associated with a higher risk of congenital heart defects., miR-10b, is a negative regulator of the CYP11B1 and CYP11B2., miR(21/10b) ratio is an independent prognostic factor for clear cell renal cell carcinoma, which could be useful to identify high-risk patients who could benefit from increased surveillance., found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b, miR-520d-5p targeting of TWIST1 resulted in reduced expression of the prominent metastamiR miR-10b, MiR-10b is highly expressed in metastatic breast cancer MDA-MB-231 cells., High-expression of microRNA-10b is asociated with cancer., we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets., This study reports the first evidence of miR-10b over-expression in NPC patients. Furthermore, our findings can support hsa-miR-10b gene regulation through LMP1/Twist1 in NPC malignancy, miR10b is potentially involved in the invasion of colorectal cancer., miR-10b contributed to abnormal vascular smooth muscle cell proliferation through inhibiting the Akt pathway by targeting TIP30 in atherosclerosis, Downregulation of miR-10b directly derepresses the expression of BCL2L11, an apoptosis inducer., Inhibition of miR-10b represses E2F1-mediated transcription, leading to down-regulation of multiple E2F1 target genes and stalling progression through the S-phase of cell cycle., these findings offer convincing evidence that increased miR-10b expression may be an independent marker to predict poor prognosis in patients with gliomas., MiRNA-10b expression levels in PBMCs can distinguish nonsmall-cell lung cancer (NSCLC) patients from cancer-free subjects , suggesting that miRNA-10b expression in PBMCs is a valuable diagnostic and prognostic marker in NSCLC, MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin., miR-10b-5p has a role in Huntington's disease brain related to age of onset and extent of striatal involvement, MiR-10b directly targets the 3'-UTRs of ZEB1 and PIK3CA., Silencing of miR-10b inhibited cancer cell progress by arresting cell cycle progression in the G0/G1 phase and promoted apoptosis non-small cell lung cancer cells., miR-10b was upregulated in gastric carcinoma and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4., Results show that overexpression of miR10b in ER-positive breast cancer cell lines led to increased resistance to tamoxifen and HDAC4 was identified as its direct target. MiR10b-HDAC4 nexus may be one of the molecular mechanism of tamoxifen resistance., Data suggest that microRNAs miR-10b, 21, 200c, 373 and 520c may control both metastasis and stemness potential., The expression levels of miR10b and miR135b are higher in semen with strong tissue specificity., Inhibition of miRNA-10b abrogated the colony-forming capability of medulloblastoma cells, and markedly down-regulated the expression of BCL2. Down-regulation of BCL2 by antisense oligonucleotides or siRNA also significantly down-regulated miRNA-10b., Enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis., matrix metalloproteinase 1 (MMP1) may be involved in the miR10b/BDNFmediated chondrosarcoma cell migration and invasion in JJ012 cells., Results suggest that miR-10b demethylation plays a tumor-suppressive role in renal cell carcinoma.,
OFFICIAL_GENE_SYMBOL MIR10B,