Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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microRNA 10a(MIR10A) microRNA 10a(MIR10A) Related Genes Homo sapiens
CYTOBAND 17q21.32,
GENERIF_SUMMARY miRNA 17-5p, 20a and 126 are constitutively expressed in Ph(-) MPN megakaryopoiesis while low or absent miRNA 10a appeared to correlate with strong megakaryocytic HOXA1 protein expression, down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of chronic myeloid leukemia implicating a miRNA in its abnormal behavior, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts; in addition, members of the miR-10 family are de-regulated in several cancer forms, MiR-10a is associated with the process of HOXA 1-mediated transformation., Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer., expressed altered in esophageal squamous cell carcinoma, changes in miR-10a and -10b expression levels may regulate SFRS1-dependent alternative splicing and translational functions., The miR-10a has major roles in the process of neural cell differentiation through direct targeting of NCOR2, which in turn induces a cascade of primary and secondary transcriptional alterations., miR-10a is specifically upregulated in nucleophosmin 1 (NPM1) mutant AML bone marrow. A robust negative relationship exists between miR-10a overexpression & MDM4 downregulation., This study provides, for the first time, in vitro evidence of a pro-survival role of miR-10a in NPM1mut-AML, that it may contribute to the pathogenesis of NPM1 mutated (NPM1mut)-AML and identifies putative tumorogenic targets., MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness., miR-10a expression is upregulated in cervical cancer tissues, and miR-10a promotes cell growth, migration and invasion by targeting CHL1 in human cervical cancer cells., Data show that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in umbilical venous endothelial cells inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling., miR-10a expression is downregulated in hepatocellular carcinoma compared to non-tumor tissue., TWIST-1 and miR10a/b expression are dysregulated in MDS. Expression of miRs10a/b is controlled by TWIST-1., miR-10a can promote hepatocellular carcinoma (HCC) migration and invasion in vitro but suppresses the metastasis of HCC in vivo, microRNA-10a and microRNA-30d have roles in kidney injury, Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting., MiR-375 and miR-10a were overexpressed in medullary thyroid carcinoma., MiR-10a restores the differentiation capability of aged hMSCs through repression of KLF4., In conclusion, our studies in multiple bladder cancer cell lines and primary non-malignant urothelial cells suggest that hypermethylation of miR-152, miR-10a and miR-200b regulative DNA sequences might serve as epigenetic bladder cancer biomarkers., miR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen., TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN., miR-10a was up-regulated during endodermal differentiation of PMSCs and involved in its differentiation partially via the suppression of the Hoxa1 gene, This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs., miR-10a acts as a tumor suppressor in GC cells and is partially silenced by DNA hypermethylation in GC, suggesting that miR-10a may serve as a potential diagnostic or therapeutic target of GC., MicroRNA-10a has a role in controlling airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway, miR-10a inhibits TBX5 expression at the level of translation. Higher levels of miR-10a expression are associated with a higher risk of congenital heart defects., miR-10a is overexpressed in cervical tumor tissues with lymph node metastasis, and miR-10a may significantly enhance the migration and invasion capacities of cervical cancer cells by inhibiting PTEN at the transcriptional level., Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b, In heavy alcohol drinkers, MIR10A expression was upregulated in blood following psychological stress but not in moderate drinkers., we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression, Human fetal hypoplastic congenital diaphragmatic hernia (CDH) lungs have a specific miR-200/miR-10a signature., MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway, Therefore, the expression of ADAR1 and ADAR2 was analyzed in chordoma tissues. It was found that ADAR1 was significantly overexpressed, which was accompanied by enhanced pre-miR-10a and pri-miR-125a A-to-I editing, Human miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect glioma cell migration and invasion., MIR10A plays a potential tumour suppressor role in human breast cancer., MiRNA-10a is upregulated in non-small cell lung carcinoma and activates PTEN/AKT/ERK pathway., miR-10 is specifically expressed in the developing human hindbrain and spinal cord, and regulates a large number of genes enriched for functions including transcription, actin cytoskeleton and ephrin receptor signaling., MicroRNA assays are shown to have great potential to be accurate and noninvasive methods for ESCC screening. In this study, we selected 3 microRNAs, miR-10b, miR-29c, and miR-205, to assess their diagnostic value in ESCC screening.,