Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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lumican(LUM) lumican(LUM) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q21.3-q22,
ENSEMBL_GENE_ID ENSG00000139329,
GENERIF_SUMMARY Expression and accumulation of lumican protein in uterine cervical cancer, the lumican protein synthesized by cancer cells, fibroblasts and epithelial cells with mild reactive dysplasia found adjacent to cancer cells may affect the growth of human colorectal cancer cells., Lumican protein has an inhibitory effect on HEK 293 cell growth in vitro., Inverse regulation in the expression of endoglin and lumican., studies of lumican-transfected melanoma cells suggest that lumican is involved in the control melanoma growth and invasion and may be considered, like decorin, as an anti-tumor factor from the extracellular matrix, Malignant cells can actively influence the composition of the extracellular matrix through TGFbeta1 and other soluble factors., No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze., An SNP (rs3759223), which is located in the promoter region of the lumican gene, may be worth further investigation to determine its association with development of high myopia., metastatic melanoma cell lines were found to express lumican mRNA and effectively secrete lumican in a proteoglycan form, characterized to be substituted mostly with keratan sulfate chains; lumican mRNA was not detected in normal melanocytes, In addition, no pathogenic sequence variations were found in DCN, DSPG3, LUM, PITX2 and FOXC1, which have also been implicated in corneal and anterior segment dysgenesis., Lumican expression in stromal tissues plays an important role in the growth and invasion of pancreatic cancer., lumican expression may be positively correlated with the differentiation and negatively correlated with the progression of osteosarcoma, Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., Multiple core-protein species were detected for decorin, biglycan, lumican and keratocan in the degenerate osteoarthritic articular cartilage and menisci., Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding., the transcripts upregulated according to disease progression were associated with signaling pathway/transcription, including tumor-associated calcium signal transducer 1 and chemokine ligand 19, and with cell communication, such as collagen., Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma., Genetic variation in lumican gene is associated with breast cancer., The study does not support the association of high myopia with alleles of rs2229336 in TGIF, rs3759223 in lumican, rs1982073 in TGFB1, and rs3735520 in HGF., Histologically progressive nonalcoholic fatty liver disease is associated with overexpression of lumican., the cytoskeleton remodeling and the decreased pFAK phosphorylation induced by lumican in melanoma cells might explain, at least in part, the anti-invasive effect of lumincan, Data suggest that five novel genes, LUM, PDE3B, PDGF-C, NRG1 and PKD2, have great potential for predicting the efficacy of cisplatin-based chemotherapy against OSCC., Genetic variation in the regulatory domains of the lumican gene, where both rs3759223 and rs3741834 are located, are associated with high myopia susceptibility among the Han Chinese., These observations suggest that LUM gene polymorphisms contribute to the development of high myopia., determined the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration, four polymorphisms of the LUM promoter contribute to the pathogenesis of high myopia., lumican protein plays important roles in the inhibition of HEK cell attachment and growth, and it might inhibit the activation of integrin pathways, Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region., lumican may play a key role in the generation of a new collagen network by fibroblast-like cells, regulates osteosarcoma cell adhesion by modulating TGFbeta2 activity, Single nucleotide polymorphisms in lumican gene are associated with systemic lupus erythematosus in the Taiwan Chinese Han population., lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta., Lumican may be a potential acute aortic dissection (AAD)-related serum marker that may assist the diagnosis of AAD., The reduction in keratan sulfate levels and the strong correlation between chondroitin 6-sulfate and keratan sulfate levels indi-cates suppressed cartilage turnover after arthroscopic surgery., Lack of Lumican expression is associated with recurrence in colon cancer., LUM in combination with other known markers, such as CRP, could be evaluated as a panel of biomarkers of POAD., Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China., lumican expression and its presence in ECM has an impact on colon cancer cells motility and may modulate invasiveness of colon cancer., The current study did not support an association between the promoter SNPs of the LUM gene with high myopia in the Korean population., lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression, Cardiac levels of lumican is increased in experimental and clinical heart failure., Lumican gene can promote the proliferation of lung adenocarcinoma cell A549, and its mechanism may be related to increased RhoC and p-Akt protein expressions., These findings suggest that lumican is a potent differential diagnostic marker that distinguishes hidroacanthoma simplex from clonal-type seborrheic keratosis., These findings suggest that lumican plays an important role in the pathogenesis of Bowen disease and actinic keratosis, Both lumican and decorin are involved in collagen fibrillogenesis and stability., lumican may be involved in cell growth and invasion through the regulation of 24 proteins expressed in pancreatic ductal adenocarcinoma., This meta-analysis showed the evidence that SNP rs3759223 may affect individual susceptibility to high myopia in the Chinese population., Lumican binds ALK5 to promote epithelium wound healing, meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers, The results suggest that regions within LUM is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties., Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line., This meta-analysis has suggested that there is a lack of association of the rs3759223 polymorphism with high myopia risk., This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia., Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone, fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha secrete the small leucine-rich proteoglycan lumican.,
OFFICIAL_GENE_SYMBOL LUM,
SP_COMMENT developmental stage:Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan., PTM:Sulfated on tyrosine residue(s)., similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily., similarity:Contains 12 LRR (leucine-rich) repeats., subunit:Binds to laminin., tissue specificity:Cornea and other tissues.,