Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
DAVID Functional Annotation Table
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LIM domain 7(LMO7) LIM domain 7(LMO7) Related Genes Homo sapiens
CYTOBAND 13q22.2,
GENERIF_SUMMARY Lmo7 positively regulates many EDMD-relevant genes (including emerin), and is feedback-regulated by binding to emerin., functional interaction between emerin and Lmo7 is crucial for temporally regulating the expression of key myogenic differentiation genes., show that LMO7 is upregulated in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of serum response factor target genes, Data suggest that Lmo7 is localized at the perinuclear region and in fibril-like structures along subsarcolemma of human skeletal myoblasts whereas in human myotubes Lmo7 is found diffuse throughout the cytoplasm.,
SP_COMMENT sequence caution:Intron retention., similarity:Contains 1 CH (calponin-homology) domain., similarity:Contains 1 LIM zinc-binding domain., similarity:Contains 1 PDZ (DHR) domain., tissue specificity:Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.,