Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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ras homolog family member A(RHOA) ras homolog family member A(RHOA) Related Genes Homo sapiens
CYTOBAND 3p21.3,
GENERIF_SUMMARY Altogether, these results identify a mechanism by which RhoB but not RhoA antagonizes TGF-beta action through transcriptional down-regulation of AP1 in T beta R-II promoter., Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation, Expressed in myometrium, Our findings indicate that different signaling cascades resulting in the activation of RhoA... can modulate the exocytotic process of neuroendocrine cells., role in sustaining integrin alphaIIbbeta3 adhesion contacts under high shear, inhibition of protein geranylgeranylation and RhoA pathways induce apoptosis in HUVEC and that induction of p53 or other proapoptotic proteins is required for this process, Data show that TGF-beta-induced rearrangements of the actin filament system required the activity of the Rho GTPases Cdc42 and RhoA, because ectopic expression of dominant negative mutant Cdc42 and RhoA abrogated the response., Structural basis for the selective activation of Rho GTPases by Dbl exchange factors., existence of a novel molecular mechanism by which Galpha(q) and the large family of G(q)-coupled receptors can regulate the activity of Rho and its downstream signaling pathways, Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells., RhoA play essential role in regulating the formation of dendritic processes by dendritic cell, cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions, Data show that protein kinase C delta (PKC delta) is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for leukotriene D(4)-induced stress-fibre formation., These results demonstrate that Rho family small GTPases RhoA, Rac1 and Cdc42 are novel signal transducers for SP-stimulated IL-8 expression., acted on by XPLN, a guanine nucleotide exchange factor, RhoA is a novel signal transducer for bacterial lipopolysaccharide-induced Toll-like receptor 4-mediated proinflammatory cytokine synthesis in monocytes., These data indicate that Rho GTPases, most likely RhoA, play an important role in uterine epithelial RL95-2 cells for trophoblast binding, and suggest that RhoA may be involved in local signalling cascades during early embryo implantation in vivo., Results suggest a novel mechanism of RA signaling, which involves activation of TGase and transamidation of RhoA., a role for RhoA in mediating tumor metastasis independent of their affects on cell proliferation, basal release of NO is necessary to maintain RhoA expression and RhoA-dependent functions in vascular smooth muscle cells, RhoA signaling and cytoskeletal rearrangement are observed in prostate cancer cells, most likely the result of direct PAR1 and PAR2 activation by serine proteases thrombin and trypsin., RhoA-mediated signaling may regulate different events in SCLC and NSCLC cells, including adhesion of SCLC cells and proliferation of NSCLC cells., Data show that inhibition of endogenous RhoA, Rac1, and Cdc42 by their respective dominant negative mutants inhibits neurotensin-induced interleukin-8 protein production and promoter activity., ADP-ribosylated form activates phospholipase D1, RhoA activation plays an integral role in tissue factor expression in endothelial cells., evidence that the small GTPases RhoA and Rac1, but not Cdc42, are directly associated with Tyk2 and PI3-K in an uPA/uPAR-dependent fashion and are necessary to mediate the uPA/uPAR-directed migration via the Tyk2/PI3-K signalling complex in human VSMC, Rho activation signals interaction of IP3R with TRPC1 at the plasma membrane of endothelial cells, and triggers Ca2+ entry following store depletion and the resultant increase in endothelial permeability, These findings show that vasodilator-stimulated phosphoprotein and diaphanous 1 function cooperatively downstream of Rho to control F-actin assembly and serum response factor activity., Up-regulation of this protein is associated with tumor progression in ovarian carcinoma., RhoA is involved in the control of the filamentous actin/monomeric actin balance through mDia, and this balance is critical for T cell responses., RhoGAP-Rho chimeras specifically down-regulate RhoA, RhoB and RhoC activity and demonstrated that this approach may be applied to multiple human tumor cells to reverse the growth and/or invasion phenotypes associated with a distinct subtype of Rho GTPase, Rac1 and RhoA bind to adherens junctions and myosin light chain during formation of capillary vascular network, The reorganization of actins into podosomes is controlled by RHOA., M-RIP can assemble a complex containing both RhoA and Myosin phosphatase myosin binding subunit, suggesting that M-RIP may play a role in myosin phosphatase regulation by RhoA, analysis of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1, RhoA binds to the amino terminus of, activation of Rho GTPases and coordinated rearrangement of F-actin within uterine epithelial cells in response to trophoblast binding are part of a generalized structural and functional reorganization of the cytoplasm., actin and RhoA are involved in inhibition of tumor cell motility by antineoplastic agents, propose that RhoA triggers signalling pathways that, upregulating expression of a proteinase at specific membrane localizations, may confer an highly invasive phenotype to endothelial cells, Smurf1 links the Cdc42/Rac1-PAR6 polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements, ROCKI interacts with the switch regions of RhoA, Activation of Rho is key mechanisms by which collagen I provokes capillary morphogenesis of microvascular endothelial cells, rhoA and rac-1 participate in cell sensitivity to mechanical strain and lead to the modulation of the Erk pathway, GIT1 redistribution occurs independently of Rac and requires RhoA and Rho kinase., Cell shape regulated the switch in lineage commitment by modulating endogenous RhoA activity. Expressing dominant-negative RhoA committed hMSCs to become adipocytes, while constitutively active RhoA caused osteogenesis, RhoA, mDia, and ROCK have roles in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition, RhoA is another regulatory element for the completion of store-operated calcium entry-induced phosphatidylserine transmembrane redistribution in megakaryocytes, RhoA/Rho-kinase pathway followed by tyrosine phosphorylation of FAK and paxillin leads to ATP release and actin reorganization in vascular endothelium, Potassium chloride acts in part through stimulation of Rho and ROCK, possibly secondary to voltage-dependent Ca2+ influx, GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription., Coordination of both RhoA and Rac1 activity contributes to bronchial epithelial wound repair mechanisms in vitro., RhoA activity is regulated in a cell-specific manner during cytokinesis, Results indicate that phospholipase Cepsilon is a direct downstream effector for RhoA and that RhoA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase., RhoA binds to leukemia-associated Rho guanine-nucleotide exchange factor, RhoA may play a critical role in the carcinogenesis of gastric cancer, multiple effector-binding sites in RhoA have roles in effector activation, RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity. (RhoA), DH domain makes several specific interactions with RhoA residues not conserved among other Rho family members, suggesting the molecular basis for the observed specificity, The antagonistic roles of RhoA and Rac1 in cell motility/invasion and cytoskeletal organization in breast cancer may be due to their concerted action on NHE1 activity as a convergence point., The RhoA pathway signals thrombin-induced ICAM-1 expression through activation of I kappa B kinase, which promotes NF-kappa B binding to ICAM-1 promoter and phosphorylation of RelA/p65, thus mediating transcriptional activation of bound NF-kappa B., RhoA impedes and RhoC stimulates invasion in breast cancer., OxLDL has a dual effect on cell-cycle progression via regulation of p27(Kip1) expression, resulting in cellular proliferation and hypertrophy, involving activation of RhoA, up-regulation of RhoA induced by low-oxygen conditions may play an important role in regulation of HIF-1alpha expression in trophoblast cells., epithelial cell motility is modulated by integrin engagment through RhoA/ROCK and PAK1, in thrombin-stimulated endothelial cells, the unprocessed form of RhoA is rapidly geranylgeranylated to become the mature form, which then is converted into GTP-bound active RhoA, prenylated proteins (at least RhoA, RhoB and/or RhoC) antagonize the ability of ERalpha and ERbeta to stimulate ERE-dependent transcriptional activity, potentially acting through both AF-1 and AF-2 transcriptional activities, these results indicate that RhoA differentially modulates cancer cell death depending on the anticancer agent., siRNAs inhibited cell proliferation and invasion more effectively than conventional blockers of Rho cell signaling, formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation, The small GTP-binding protein RhoA is able to stimulate the phospholipid phosphatase activity of PTEN in human embryonic kidney cells and leukocytes., fMLP-induced activation of NF-kappaB utilizes a signaling pathway requiring activity of PKCepsilon, a signaling component downstream of RhoA in cytokine gene transcription stimulated by a chemoattractant, RhoA has a role in ABCA1-mediated cholesterol efflux, a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module is regulated by Protein Kinase A gating and then regulates invasion in breast cancer cell lines, Ser188 phosphorylation-mediated protection against degradation is a physiological process regulating the level of endogenous RhoA and define a novel function for RhoGDI, as an inhibitor of Rho protein degradation., Activation of small RhoGTPases is a key step in the mechanism of epithelial mesemchymal transdifferentiation and likely to be a contributor to tubulointerstitial fibrosis., study suggests that RhoA may represent a key molecule in the signalling transduction pathway of profibrotic signals in IgA nephropathy, overexpression of the active form of the small GTPase RhoA induces the activation of Epidermal Growth Factor Receptor and promotes cell motility, Rho signaling exerts an unexpectedly complex role in keratinocyte differentiation, which is coupled with induction of KyoT1/2, a LIM domain protein gene with a potentially important role in control of cell self renewal., Central spindle localization of ECT2 assists division plane positioning and the CYK-4 subunit of centralspindlin acts upstream of RhoA to promote furrow assembly., In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA-C-specific downstream effects., Cdk1 inactivation is sufficient to activate a signaling pathway leading to cytokinesis, which emanates from mitotic spindles and is regulated by ECT2, MgcRacGAP, and RhoA, phosphorylation of ECT2 leads to accumulation of RHOA, The results suggest that oncogenic K-Ras enhances the malignant phenotype and identify the mitogen-activated protein kinase p38 as a target to inhibit oncogenic K-Ras-induced pancreatic tumor cell migration., FAK-induced down-modulation of RhoA activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability, Data show that RhoA accumulates at the equatorial cortex before furrow initiation and continues to concentrate at the cleavage furrow during cytokinesis, and that centralspindlin and ECT2 are required for this localization and furrowing., HEF1 associates with the RhoA-GTP exchange factor ECT2, an orthologue of the Drosophila cytokinetic regulator Pebble, providing a direct means for HEF1 control of RhoA., Lysoophosphatidic acid stimulates RhoA and increased PC-3 prostate cancer cell invasion activity through an NF-kappaB-dependent pathway., findings show that the vaccinia F11L protein interacts directly with RhoA, inhibiting its signaling by blocking the interaction with its downstream effectors Rho-associated kinase (ROCK) and mDia, Data show that the HR1 region is necessary but not sufficient in eliciting a full activation of PRK1 upon binding of RhoA, and that activation is controlled by the very C-terminus of PRK1., Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling, REVIEW, CB2 might play a role in regulating excessive inflammatory response by controlling RhoA activation, thereby suppressing neutrophil migration, F-actin constrains cell polarity by locally reducing activation of RhoA, thereby reducing its active form at the front. Mutual incompatibility of frontness and backness is responsible for self-organization of neutrophil polarity., Escherichia coli producing cytotoxic necrotizing factor and transforming growth factor-beta trigger activated RhoA ubiquitylation through Smurf1 ubiquitin-ligase., Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes., cGMP-dependent protein kinase expression is regulated by Rho and Kruppel-like transcription factor-4, PTP1B mediates of RhoA-dependent phosphorylation of p130Cas., Our data indicate that TGF-beta1 induces endothelial barrier dysfunction involving Smad2-dependent p38 activation, resulting in RhoA activation by possible transcriptional regulation., Both neuropeptides that activate G-protein-coupled receptors and growth factors that activate receptor tyrosine kinases require RhoA to induce prostate cancer cell migration., These findings indicate for the first time that activation of geranylgeranylated proteins including RhoA and Rac1 is involved in type III GBS invasion of HBMEC and RhoA is upstream of Rac1 in GBS invasion of HBMEC., In human lung fibroblasts, bradykinin modulates the action of AngII through the small G protein RhoA, but in a Galphai/Galphaq-independent manner., the role of RhoA GTPase in protein kinase D activation depends on the cellular localization of protein kinase D, cyclin D1 expression is deregulated in idiopathic pulmonary fibrosis through a RhoA dependent mechanism that influences lung fibroblast proliferation, PIP3 and Cdc42 maintain stable polarity with a single front and a single back not only by strengthening pseudopods but also, at longer range, by promoting RhoA-dependent actomyosin contraction at the trailing edge., These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA., our study demonstrates increased expression of RhoA in high-grade astrocytomas, study investigated the role of RhoA and Rho-kinase in endothelial eNOS protein expression under hypoxic conditions, Because of its efficacy and the absence of toxicity, it is suggested that this strategy of anti-RhoA siRNA holds significant promise for the treatment of aggressive cancers., RhoA and RhoC are downstream of PKC epsilon & critical for PKC-epsilon-mediated cell invasion & motility. PKC epsilon coordinately regulates RhoA & RhoC activation, possibly through direct post-translational phosphorylation., findings suggest a new, 2-faced role for RhoA as a checkpoint in innate immunity, ARAP2 is an Arf6GAP that functions downstream of RhoA to regulate focal adhesion dynamics., gene copy multiplication and demethylation of the RHOA promoter region can contribute to transcription activation of this gene in epithelial tumors, These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis., In this study, we provide evidence that PV-immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling., Silencing of RhoA expression with siRNA increased the levels of E-cadherin and alpha-catenin in colon cancer cell ines., These results suggest that Smurf1 is a pivotal regulator of tumor cell movement through its regulation of RhoA signaling., Galphaq activation of TRPC6 signals the activation of PKCalpha, and thereby induces RhoA activity and endothelial cell contraction, RhoA signaling has a role in lung cancer, The RhoA gene, rs2878298, showed highly significant genotypic association with both smoking initiation (SI) and nicotine dependence (ND). In the allelic analyses, rs2878298 was only significant for SI., RGS3L functions as a molecular switch, redirecting Gi-coupled receptors via Gbetagamma-dimers and PI3K from Rac1 to RhoA activation., Increases in GTP-bound RHOA and DIAPH1 expression may contribute to the increase in uterine activity in idiopathic preterm labor., Maspin control mammary tumor migration through inhibiting Rac1 and Cdc42, but not RhoA GTPase., These data suggest that p53 suppresses cancer progression to malignancy by modulating the quality of Ras signaling., NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling., Polo-like kinase 1 has a role in positioning RhoA and triggering cytokinesis in human cells, Plk1 and RhoA function to enhance Rock2 kinase activity in vitro and within cells, and implicate Plk1 as a regulator of multiple pathways that synergistically converge to regulate actomyosin ring contraction during cleavage furrow ingression., These results identify a GEF-H1-dependent mechanism to modulate localized RhoA activation during cytokinesis under the control of mitotic kinases., These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program., Activation of PAR1-induced dynamic cytoskeletal reorganization and reduced PC-3 binding to collagen I, collagen IV, and laminin (P < 0.01) but not fibronectin., analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway, NFAT-dependent gene expression was modulated by the RhoA signaling pathway in T-lymphocytes., Data suggest that lipid rafts play critical roles in KSHV infection and gene expression, probably due to their roles in modulating KSHV-induced PI3-K, RhoA-GTPase, and Dia-2 molecules essential for postbinding and entry stages of infection., Results of this study suggest that the Rho-family GTPases are required for efficient invasion of HeLa cells by GBS., Ang-1 phosphorylates Tie-2 and its downstream effector phosphatidylinositol 3-kinase. This induces activation of one endogenous GTPase, Rac1, and inhibition of another, RhoA, findings suggest that the RhoA is related to malignant transformation and progression of colorectal cancer and the activation of RhoA is associated with lymph node metastasis., Co-immunoprecipitation reveals that RhoA and polo-like kinase 1 physically interact and that their interaction appears to be enhanced during mitosis., the crucial role of the phosphorylation of the C terminus of GDI-1 at S96 in selectively activating RhoA, Inhibitory role of RHOA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity is reported., These results suggest the existence of a feedback loop between cytoskeletal tension, adhesion maturation, and ROCK signaling that likely contributes to numerous mechanochemical processes., FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42., Sphingosine 1-phosphate inhibited monocyte-endothelial interactions by inhibiting RhoA activity which may explain its anti-atherogenic effects, plexin-B1 promotes endothelial cell motility through RhoA and ROK by regulating the integrin-dependent signaling networks that result in the activation of PI3K and Akt, High expression of RHOA is associated with esophageal squamous cell carcinoma, Expression level of RhoA is correlated with tumor progression and metastasis in hepatocellular carcinoma., BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases., tethering of RhoA to the membrane by GGpp is determinant for T cell migration, OLIG2 suppresses the motile phenotype of glioblastoma cells by activating RhoA., These results indicate that START-GAP3/DLC3 has characteristics similar to other START-GAPs and the START-GAP family seems to share common characteristics., The vaccinia virus-induced increases in peripheral microtubule dynamics require F11L-mediated inhibition of signaling via the GTPase RhoA and its effector, mDia., cortical movements and the subsequent release of vaccinia virus particles, which are both actin dependent, require F11L-mediated inhibition of RhoA-mDia signaling., These results suggest induction of SRF-mediated transcription by alpha(E)-catenin either downstream of RhoA or via a parallel pathway., Rho kinase and ERK1/2 play more important roles than RhoA in PGE(2)-mediated migration stimulation of first-trimester trophoblasts., These results suggest that S1P(2) receptors/G(12/13)-proteins/Rho signaling pathways mediate S1P-induced inhibition of glioma cell migration., the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF was determined, TBXA2R are expressed in prostate cancer and activation of TBXA2R regulates prostate cancer cell motility and cytoskeleton reorganization through activation of RhoA., reveal PECAM-1 signaling and interactions with the cytoskeleton, which are required for CAM-endocytosis, and may provide safe intra-endothelial drug delivery by anti-PECAM/nanocarriers, data suggest that EPHA2 promotes tumor malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions, TGFbeta1 stimulates CCN2 expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism, These studies reveal a critical role for a GEF-H1/RhoA/ROCK/MLC signaling pathway in mediating nocodazole-induced cell contractility., Particular chemokine signals activate, within subseconds, the RhoA 23/40 domain to induce lymphocyte function-associated antigen-1 (LFA-1) extension and thereby trigger LFA-1-mediated lymphocyte arrest on ICAM-1., in SGC-7901 gastric cancer cells RhoA was found to be localized within the membrane, the cytosol, and the nucleus, Data suggest that TGF-beta1 induces human retinal pigment epithelial cells to undergo cytoskeletal actin rearrangement via RhoA GTPase-dependent pathways that modulate LIM kinase and cofilin activity., TGFBR1*6A may contribute to cancer progression through RhoA activation in a TGF-beta signaling-independent manner, The purpose of this study was to characterize the significance of Rho processes in the cellular cytoskeleton., These data indicate a novel role for RhoA as a negative regulator of HIF-1alpha., Human ARHGAP6 protein possessing GTPase stimulating activity for RhoA on the catalytic properties of PLC-delta1, was studied., findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation, Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling., RhoA/Rho-associated kinase signaling plays positive and negative roles in myogenic differentiation, mediated by MRTF-A/Smad-dependent transcription of the Id3 gene in a differentiation stage-specific manner, RhoA protein expression correlated with overall survival of patients with pancreatic ductal adenocarcinoma.., The effect of OGP(10-14) on differentiation of a cancer megakaryoblast cell line and its involvement on RhoA and Src family kinases signaling pathway, was evaluated., RhoA mediated cell survival in cells exposed to DNA damaging agents is modulated by Net1, in basal conditions, RhoGDIalpha is rate-limiting and the suppression of RhoA makes it available to stabilize RhoB, The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation., activation of the RhoA GTPase was defective in VHL(-) cells, and this was possibly mediated by an increased activation of its inhibitor, p190RhoGAP., The association of lymphocyte RhoA protein expression with classical clinico-pathological parameters closely corresponded with that observed for RhoA protein expression in the tumor biopsies., WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation., Ca(2+) sensitization mediated by the RhoA-kinase pathway has an important role in contraction of human esophageal body (EB) and lower esophageal sphincter (LES) muscles., decreased DLC2 expression in hepatocellular carcinoma correlates with cell differentiation and overexpression of RhoA associated with poor prognosis, Netrin 1, through its receptor DCC, inhibits RhoA in embryonic spinal commissural neurons., ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity., Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61., Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein., Data suggest that RhoA and B small GTPases, along with ROCK, are major membrane androgen receptor effectors controlling actin reorganization and apoptosis in prostate cancer cells., Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q, Staphylococcal enterotoxin B-treated renal proximal tubule epithelial cells show down regulation of Rnd3 and mRNA for RhoA was shown to increase., RhoA mRNA expression is significantly lower in cancerous as compared to normal kidney tissue. RhoA protein expression is significantly higher in normal than in cancerous tissues., a link between RhoA, JNK, c-Jun, and MMP2 activity that is functionally involved in the reduction in osteosarcoma cell invasion by the statin. This suggests a novel strategy targeting RhoA-JNK-c-Jun signaling to reduce osteosarcoma cell tumorigenesis., Treatment with lysophosphatidylinositol induces marked GPR55 internalization and stimulates a sustained, oscillatory calcium release pathway, which is dependent on Galpha13 and requires RhoA activation., p27 promotes cell migration in metastatic HCC cells through the regulation of RhoA activity., the directional migration of capillaries in the embryo is governed by the Amot, the importance of NET1 as a driver of tumour cell invasion, an activity mediated by RhoA activation and cytoskeletal reorganisation., IMC-C225 cross-links integrins with EGFR, leading to Vav2-dependent activation of RhoA, the last seven amino acid residues at the C-terminus of PRK2 are not required for the activation of the kinase by RhoA in vitro, however, the extreme C-terminal segment is critical for the full activation of PRK2 by RhoA in cells, RhoA and its downstream molecule ROCK may mediate the substrate rigidity-regulated Ca(2+) oscillation, which determines the physiological functions of human mesenchymal stem cells., MLK3 functions in a regulated way to limit levels of the activated GTPase Rho by binding to the Rho activator, p63RhoGEF/GEFT, which, in turn, prevents its activation by Galphaq., G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis., RhoA pathway is implicated in suppression of MM migration and invasion, Graf residues important for the structural integrity are critical for binding RhoA and for the catalytic activity of GAP, but GTPase selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface., EB1 is controlled by c-Myc, RhoA, and CDC42, which have all been linked to hepatocellular carcinoma (HCC) malignancy., Guanosine Triphosphate binding protein, RhoA is activated downstream the Proton-Translocating ATPases /P2Y13 protein signalling payway., HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha., Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility., Treatment with angiotensin II markedly promoted the protein and mRNA expressions of RhoA in hepatic stellate cells., SifA, SKIP, SseJ, and RhoA family GTPases cooperatively promote host membrane tubulation., ARHGAP5 (the gene encoding p190-B RhoGAP) is a probable target for the amplification at 14q12, and p190-B RhoGAP promotes cells spreading and migration by negatively regulating RhoA activity in Huh-7 hepatocellular carcinoma cells, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1., Overexpression of RHOA enhances peritoneal dissemination, analysis of the the antiparallel coiled coil motif from PKN complexed with RhoA, ET-1 induces Rho-kinase activation and subsequent phosphorylation of p190A RhoGAP, leading to prolonged RhoA activation., S100B interacts with Src kinase, thereby stimulating the PI3K/Akt and PI3K/RhoA pathways., Ectopic expression of wild-type (WT) RhoA as well as a constitutively active RhoA mutant (G14V) in two independent primary human mammary gland epithelial cells strains led to their immortalization and preneoplastic transformation., p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities., PRL-3 up-regulates pERK and Rho expression and activity in lung cancer, After disruption of cell-cell contacts, PKD1 relayed RhoA activation to the induction of the transcription factor NF-kappaB., Rac1 and RhoA signaling simultaneously regulate cell invasion in 3D matrices., RhoA plays a role downstream of MyD88-dependent and -independent Toll-like receptor (TLR) signaling and acts as a molecular switch downstream of TLR-protein tyrosine Src-initiated pathways., p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound p120ctn contributed to RhoA inactivation by favoring p190RhoGAP-RhoA association., Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation., a molecular mechanism for the pathogenesis of cerebral cavernous malformations (CCM) resulting from loss of CCM2-mediated localization of Smurf1, which controls RhoA degradation required for maintenance of normal endothelial cell physiology., Increased RhoA expression is associated with gastric cancer., Data indicate that RhoA/Rok is involved in substratum-mediated regulation of insulin signaling in MECs, and under the conditions where proper adhesion to BM is missing, insulin-mediated cellular differentiation and survival would be defective., Both receptor-stimulated and steady-state Kv1.2 trafficking modulated by RhoA/ROCK required the activation of dynamin as well as the ROCK effector Lim-kinase, indicating a key role for actin remodeling in RhoA-dependent Kv1.2 regulation., MyoGEF cooperates with nonmuscle myosin IIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA and RhoC., role of RhoA and Rac1 GTPases in SDF1-induced adhesion, chemotaxis, and homing of multiple myeloma cells to the bone marrow, Nox1 knockdown led to a loss of directional migration which takes place through a RhoA-dependent alpha2/alpha3 integrin switch., Increased motility of cancer cells with PI3K and/or MAPK pathway activation may result partly from RSK1 activation, accumulation of p27T198 in the cytoplasm, p27, RhoA regulates the induction of alpha-smooth muscle actin expression during epithelial to mesenchymal transition., LOX-1-MT1-MMP axis plays a crucial role in RhoA and Rac1 activation signalling pathways in ox-LDL stimulation., The significantly up-regulated RhoA expression suggest that RhoA may contribute to the initiation, development, invasion and metastasis of colorectal carcinoma in Chinese patients., These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK-dependent association of HSP27 and p115RhoGEF., Data show that loss of CD151 causes excessive RhoA activation, loss of actin organization at cell-cell junctions, increased actin stress fibers, and suggest that it is also an important regulator of the stability of tumor cell-cell interactions., In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism., KiSS1 inhibits TNFalpha-induced NF-kappaB activation via downregulation of RhoA activation and suppression of breast cancer cell migration and invasion, Data show that RhoA may regulate the invasion and metastasis of breast cancer cells as an upstream signaling of Ezrin., The increased expression of RhoA and Rho kinase in uterine smooth muscle may play an important role in the initiation of labor., Net1 requires interaction with PDZ domain proteins, such as Dlg1, to protect it from proteasome-mediated degradation and to maximally stimulate RhoA and that this interaction is regulated by cell-cell contact., These results suggest that TNF-alpha-induced upregulation of RhoA might be mediated by an activation of NF-kappaB in cultured human bronchial smooth muscle cells, The positivity rate of RhoA in the bronchoalveolar lavage fluid is higher in asthma patients allergic to dust mites than in normal healthy subjects., Data describe a proteomics strategy to identify proteins regulated by RhoA and report a new human protein, named "mediator of RhoA-dependent invasion," that is induced in metastatic cells by constitutive RhoA activation and promotes cell invasion., This study establishes GEF-H1 as a critical organizer of key structural and signaling components of cell migration through the localized regulation of RhoA activity at the cell leading edge., In summary, these results suggest that actin, likely modulated by the GTPases RhoA and Cdc42 and by bacterial proteins, is involved in the formation of the typical parasitophorous vacuole., findings demonstrate that enhanced expression of RhoC results in a striking increase in the migration and invasion of pancreatic carcinoma cells, whereas forced expression of RhoA decreases these actions, In hBSMCs (human bronchial smooth muscle cells), an up-regulation of RhoA (ras homolog gene family member A)was observed when the function of endogenous microRNA-133a was inhibited by its antagomir., Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt) decreases activation of RhoA and Rac1, and in the absence of Icmt activity, addition of exogenous RhoA or Rac1 partially rescues directed and random migration, respectively., MT1-MMP-associated protein p27RF-Rho binds p27(kip1) and prevents p27(kip1) from binding to RhoA., The activity of TG2 and RhoA is altered in Celiac disease causing increased blood vessel permeability., The expression of RhoA/Rho kinase mRNA and protein and function in the RA were significantly stronger than in the IMA, suggesting that RhoA/Rho kinase pathway may be one mechanism by which RA is more susceptible to spasm than IMA., HS could regulate fusion via fine tuning of RhoA and Cdc42 activities., m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions., Kindlin-1 forms molecular complexes with beta1 integrin, alpha-actinin, migfilin, and focal adhesion kinase and regulates cell shape and migration by controlling lamellipodia formation., TXA(2) receptor mediates water influx through aquaporins in astrocytoma cells via TXA(2) receptor-mediated activation of G alpha(12/13), Rho A, Rho kinase and Na(+)/H(+)-exchanger., Data suggest that CLIC4 is regulated by RhoA to be targeted to the plasma membrane, where it may function not as an inducible chloride channel but rather by displaying Cys-dependent transferase activity toward a yet unknown substrate., Cullin-3 mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement., These results suggest that the novel gene, Kenae/CCDC125, acts as a regulator of cell motility through RhoA, Rac1 and cdc42., Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts, RhoA plays an antagonistic role to Rac1/Cdc42 in the control of mammary epithelial acinar morphogenesis., Suggest that IL-4 is capable of inducing an upregulation of RhoA via an activation of STAT6 in cultured bronchial smooth muscle cells resulting in bronchial hyperresponsiveness., These immunohistochemistry results suggest that the overexpression of RhoA protein in breast duct carcinoma, is correlated with TNM clinical classification, presence of regional lymph node metastasis and histological grading., These findings suggest that activation of RAGE/RhoA is involved in advanced glycation end products -induced hyperpermeability through gap formation and actin reorganization in diabetes., activation of RhoA by reactive oxygen species requires a redox-sensitive motif, The findings suggest that signal transducer and activator of transcription 6 and NF-kappaB are important for the upregulation of RhoA in human bronchial smooth muscle cells, PI3-kinase regulates the thrombin-induced actin cytoskeleton reconstitution in platelets by the RhoA-mDia1 pathway., The role of F11 and its ability to interact with RhoA to inhibit its downstream signalling in the spread of vaccinia infection both in vitro and in vivo, was examined., In amyloid-beta protein precursor mice, RhoA appears sequestered by neurofibrillary tangles and hyper-phosphorylated tau inclusions., Stduies indicate that cGMP-dependent protein kinase I modulates the RhoA-ROCK pathway and insulin receptor signaling to elicit BAT differentiation and stimulate thermogenesis., [review] The small GTP-binding protein RhoA and its downstream effector protein Rho-kinase have been shown to play a novel role in the regulation of smooth muscle contraction and may have an important role in the pathogenesis of pulmonary hypertension., Data demonstrate that upregulation of RhoA immunoreactivity occurs in the brains of patients with intractable epilepsy., Mechanical stimulation of the cytoskeleton and Rho activation are key upstream events in mechanotransduction-associated alveolar epithelial cell differentiation., activation of the RhoA-ROCK-p38MAPK-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells, RHOA and PRKCZ, and their downstream effectors, can represent important pharmacological targets that could potentially control the highly metastatic attitude of pancreatic ductal adenocarcinoma., a novel physical and functional interaction between ABCA1 and PDZ-RhoGEF/LARG, which activates RhoA, resulting in ABCA1 stabilization and cholesterol efflux activity., analysis of the structure of Shigella IpgB2 in complex with human RhoA, RhoA/ROK expression and function in saphenous vein from diabetic patients is significantly increased and may contributes to a higher incidence of atherosclerosis and a lower long-term patency., oncogenic Skp2 and Myc coordinate to induce RhoA transcription and establish a novel SCF-Skp2 E3-ligase-independent function for oncogenic Skp2 in transcription and cancer metastasis., Data suggest that TM4SF5 accelerates G1/S phase progression with facilitated CDK4/cyclin D1 entry into the nucleus, which might be supported by TM4SF5-mediated actin reorganization through cytosolic p27Kip1 expression and Rho GTPase activity., Results suggest that VEGF-C promoted cervical cancer metastasis by upregulation and activation of moesin protein through RhoA/ROCK-2 pathway., Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA is involved in thrombin-induced endothelial barrier dysfunction, Our results indicate the modulation of RhoA on TLR-2-mediated inflammatory signaling in RA providing novel evidence for anti-inflammatory effects of statins through influencing TLR-2 signaling via RhoA., RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway, This work shows that RHOC and RHOA play different roles in cell-matrix adhesion, motility, and invasion of MDA-MB-231 and reaffirms the crucial role of RHOC-GTPase in inflammatory breast cancer cell invasion., arecoline induces anoikis of HA22T/VGH cells involving inhibition of STAT3 and increased RhoA/Rock activation, Smad3 regulates RhoA activation and cytoskeletal reorganization by controlling NET1 in TGF-beta1-induced ARPE-19 cells., Data suggest that PKP2 may functionally link RhoA- and PKC-dependent pathways to drive actin reorganization., Heparin inhibits pulmonary artery smooth muscle cell proliferation through GEF-H1/RhoA/ROCK/p27 signaling pathway., Data show that expression of a dominant-negative RhoA mutant or silencing DIAPH1 impaired mitochondrial trafficking and cortisol biosynthesis., Gankyrin is a key regulator of Ras-mediated activation of Akt through inhibition of the downstream RhoA/ROCK pathway and thus plays an essential role in Ras-induced tumorigenesis., incubation of breast tumor cells with recombinant Sema3A rapidly increased eIF4E activity, RhoA protein levels, and RhoA activity., Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network., the Lbc/alpha-catulin axis participates in 5-HT-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling., Data indicate that RhoA activity is dynamically regulated at the front and back of T cells to coordinate TEM., PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation, novel mechanism for regulation of proliferation in 11q13-amplified HNSCC cells, in which overexpressed cortactin acts via RhoA to decrease expression of Cip/Kip CDKIs, and highlight Skp2 as a downstream effector for RhoA in this process, Type IV pili producing Neisseria gonorrhoeae triggers a phosphotyrosine-dependent Cav1-Vav2-RhoA signaling cascade that elicits cytoskeletal rearrangements and effectively impedes bacterial uptake into host cells., RhoA is generally distributed in the nucleus of cells and the distribution increases when the cells undergo tumorigenesis, suggesting a new role for RhoA, Report mevalonate kinase deficiency compromized fiberoblast geranylgeranylation of RhoA and Rac1., Recombinant adenovirus mediated RhoA and RhoC shRNA in tandem linked expression may inhibit the growth of human colorectal tumor xenografts in vivo., STAT6 binding region is required for the IL-4-induced increase in promoter activity of the human RhoA gene, leptin activates the RhoA/ROCK/LIMK/cofilin pathway, which results in cytoskeletal reorganization in chondrocytes, rapamycin inhibits cell motility at least in part by down-regulation of RhoA protein expression and activity through mTORC1-mediated S6K1 and 4E-BP1-signaling pathways., Both activation and inactivation of RhoA signaling increased paracellular permeability in intestinal epithelium., findings have shown that interactions of LM-111 and LM-332 with adjacent epithelial cells differentially activate intracellular signaling molecules, in particular RhoA, which is critical for migration of epithelial cells on laminins, ACh stimulation regulates vinculin activation in tracheal smooth muscle via RhoA, Data demonstrate an alternate RhoA-dependent association of peroxisomes to the microtubular and actin cytoskeleton., A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC., A balance between cortical retraction forces which depend in part on RhoA activation and substrate adhesion forces governs the integrity of mitotic actin retraction fibers and influences subsequent daughter-cell spreading., Delineate a clearer path from OxLDL through the endothelial cell LOX-1 receptor, RhoA, and ROCK, to the activation of arginase II, downregulation of NO, and vascular dysfunction in atherosclerosis., propose that the mTORC2-dependent regulation of MyoII occurs through a cAMP/RhoA-signaling axis, independently of actin reorganization during neutrophil chemotaxis, RhoA may be a key molecule in esophageal squamous cell carcinoma cells, Data show that miR-185 is a negative regulator of RhoA and Cdc42 and their cellular activities, and could inhibit proliferation and invasion of colorectal cancer cells., RHOA may cause resistance of high-grade serous carcinoma to chemotherapy., These results indicate that Rho is a downstream mediator of CaR in the regulation of Ca(2+)(o)-induced E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation., the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation., Results indicate that SmgGDS is a bona fide GEF that specifically activates RhoA and RhoC through a unique mechanism not used by other Rho family exchange factors., RhoA inhibition evoked by crocidolite asbestos is prevented by antioxidants in human mesothelial and mesothelioma cells, Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis., In embryonic fibroblasts, protein levels of RhoA, ROCK1 and CTGF were up-regulated after 1.5 h of hypoxia and increased further with longer exposure to hypoxia., Dia1 mRNA localizes to the perinuclear endoplasmic reticulum through interactions between Dia1 nascent peptide and Rho-GTP., RhoA/Rho kinase regulation by Notch signaling in endothelial cells triggers a senescence phenotype associated with endothelial barrier dysfunction., During cell adhesion (induced by arachidonic acid), RhoA, nucleolin, and ROCK form a complex; cell adhesion is inhibited when formation of this complex is inhibited by various means., Ras/Raf/MAPK and RhoA/ROCKII signalling pathways are abnormally activated in eutopic endometrial stromal cells of patients with endometriosis, Data show that just one contact site as being relevant for binding of RhoA and domain from PRK1, and the HR1b domain was found not to contribute to RhoA binding., Existence of a functional Net1/RhoA signaling pathway within the nucleus of the cell and this implicates them in the DNA damage response., Reactive oxygen species-dependent protein activation is responsible for the increase in collagen-1 synthesis in lung fibroblasts, Small GTPase RhoA transgene signaling is necessary for cell junction regulation and spinal cord neuroepithelium organization preventing precocious cell-cycle exit and differentiation., cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity, RhoA may serve as a potential biomarker and an attractive therapeutic target for hepatocellular carcinoma., Hax1 is a novel regulator of neutrophil uropod detachment and chemotaxis through RhoA, After continuous blood purification treatment, RhoA-mediated endothelial hyperpermeability induced by serum from severe acute pancreatitis patients with lung injury was reduced., hypoxia decreases MSC cell migration through an HIF-1alpha and RhoA-mediated pathway, The overexpression of RhoA and NF-kappaB is involved in the occurrence and development of gastric carcinoma. RhoA is positively linked with NF-kappaB., RhoA contributes to migratory tumor cell polarity through ROCK2-mediated suppression of Rac1 activity in lamellipodia., The RhoA/ROCK signal pathway modulates the TLR-2-mediated secretion of chemokines in rheumatoid arthritis fibroblast-like synoviocytes., study shows that MT1-MMP mediates the RhoA/Ca(2+) and Rac1/NADPH oxidase-dependent signaling pathways in thrombin-induced vascular responses, In EGF-stimulated ovarian cancer cells, re-expression of ARHI inhibited FAK(Y397) and Src(Y416) phosphorylation, disrupted focal adhesions, and blocked FAK-mediated RhoA signaling, resulting in decreased levels of GTP-RhoA, RhoA signaling mediates plasticity of scirrhous gastric carcinoma motility., VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway., Data report that the C2 domain of Smurf1 is necessary and sufficient for binding RhoA, and therefore is crucial for targeting RhoA for ubiquitination., These data suggest that osteogenic growth peptide not only acts on bone marrow mesenchymal stem cells to stimulate osteogenic differentiation, but also in a dose-dependent manner, and this effect is mediated via the activation of RhoA/ROCK pathway., The PI3K-Rac1/RhoA signaling pathway plays a vital role in IL-8 induced endothelial cell migration, Inhibiting RhoA through RNA interference reduced the levels of FN, CTGF and TNF-alpha in high glucose-induced mesangial cells., RhoGDIalpha-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis, RHOA overexpression correlates with progression of non-small cell lung cancer., molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF, Data indicate that RhoA, PKCdelta and PKCepsilon modulated uPA-induced cell adhesion and polarization, whereas only RhoA and PKCepsilon were also responsible for the redirection of virions in intracellular vesicles., Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity., Suggest that RhoA/ROCK, cytoskeletal organization, and FAK compose a "signaling network" that senses mechanical stretching and drives mechanical stretch-induced tenogenic differentiation of mesenchymal stem cells., The present study was aimed at addressing the hypothesis that the activated state of RhoA GTPase signals can trigger mPGES-1., Restoration of RND3 expression or RHOA knockdown attenuated the migratory ability of residual cells without affecting overall cell survival, there may be a fundamental alteration in the communication between the external mechanical environment (extracellular forces) and reorganization of the actin cytoskeleton mediated by RhoA in leiomyoma cells., These results highlight the role of RhoA GTPase in ionizing radiation-induced deregulation of essential endothelial functions linked to actin cytoskeleton., PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation, Fasudil can reduce the secretion of downstream inflammatory factors and cytokines by inhibiting high glucose-activated HMCs Rho/ROCK signaling pathway in mesangial cells., signaling from integrin alpha6beta4 facilitates lysophosphatidic acid- stimulated chemotaxis through preferential activation of RhoA, which, in turn, facilitates activation of Rac1, Induction of RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells by Sox2 RNAi, Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization., endocannabinoids, through their autocrine activation of CB1 and subsequent repression of RhoA activity, suppress migration in prostate carcinoma cells, RhoA may have a key role in ameloblastoma neoplastic epithelial cell phenotype determination, as well as in variant and subtype determination., Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins., Data show that inhibitors of Stat3, IGF-IR and Rho GTPase were the most promising therapeutic agents for ovarian cancer., Furthermore, pharmacological manipulations of cytoskeletal tension in conjunction with analysis of gene expression revealed that mechanical properties of the microenvironment signal through the small GTPase RhoA., Results show that LPS-induced NF-kappaB activation and IL-8 synthesis in endothelial cells are regulated by the MyD88 pathway and GEF-H1-RhoA pathway., Lipopolysaccharide-induced ICAM-1 synthesis in human umbilical vein endothelial cells is regulated by GEF-H1/RhoA-dependent signaling pathway via activation of p38 and NF-kappaB., Protein kinase D regulates RhoA activity via phosphorylation rhotekin at Ser-435., It was concluded that RhoA/ROCK is active in the internal anal sphincter (IAS), and is the critical determinant of the basal tone in intact human IAS and that they are potential therapeutic targets for a number of rectoanal motility disorders., Results confirm the involvement of RhoA/ROCK pathway and subsequent moesin Thr558 phosphorylation in advanced glycation endproduct-mediated endothelial dysfunction., a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17., The signaling pathway is delineated downstream of RhoA and ROCK, which regulates astral microtubule organization at early stages of mitosis., role in sphingosine-1-phosphate induced adherence of eosinophils to pulmonary endothelium, Matrix-associated PAI-1 plays a role in the cell behavior needed for amoeboid migration by maintaining cell blebbing, localizing PDK1 and ROCK1 at the cell membrane and maintaining the RhoA/ROCK1/MLC-P pathway activation., Data suggest that RhoA expression remains unaltered during progression of prostate cancer from androgen-responsive to androgen-nonresponsive; overexpression of RhoA increases androgen-responsiveness., Elevated levels of RhoA in the ONH of glaucomatous eyes suggest possible involvement of RhoA in the pathophysiology of glaucoma., Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers., The results suggest that PKA-mediated inhibition of RhoA via its phosphorylation on serine 188., human fibroblasts expressing PDPN may promote tumor formation via a higher RhoA activity level., BDNF knockdown inhibited cell invasion probably through the blocked actin polymerization and the correlated inactivation of RhoA or Rac1., RNAi of RhoA inhibited the survival and promoted the apoptotic of gastric cancer cells., RhoA associates with SHIP2 to regulate cell polarization and migration., demonstrate that membrane extraction of Rho GTPase by RhoGDI is a thermodynamically favored passive process that operates through a series of progressively tighter intermediates, much like the one that is mediated by RabGDI, ANXA2 may act upstream of the RhoA/ROCK pathway by regulating F-actin remodeling and is a key factor in human endometrial adhesiveness, Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA., These results support the notion that UDP-glucose is a stable and potent proinflammatory mediator that promotes P2Y(14)-R-mediated neutrophil motility via Rho/Rho kinase activation., Substitution of RhoA Val 43 with an Ile was found to significantly promote basal nucleotide exchange activity and enhance guanosine triphosphate-loading in cells., Under hypoxic condition, RhoA indirectly influences HUVECs to affect tumor angiogenesis by regulating VEGF level in breast cancer cells., SseJ binding to RhoA is required for recruitment of SseJ to the endosomal network and for full Salmonella virulence, GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion., IL-8-Rac1/RhoA-p38MAPK signaling pathway plays a vital role in the IL-8-induced endothelial cell migration., The overexpression of constitutively activated RhoA(Q63L) stimulates actin cytoskeleton rearrangement and induces R-cadherin adherens junction formation., Angiotensin II induces the contraction of HASMCs and that this effect can be reversed by Ang-(1-7), partially through the downregulation of of the RhoA/ROCK2 signaling pathway., There is an oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA signalling and the epithelial mesenchymal transition phenomenon., miR-31(*) is a functional miRNA involving in regulating RhoA, and the activity of miR-31(*)'s activity seems to counteract the functions of miR-31 during OSCC tumorigenesis., the RhoA-mediated assembly of adhesome complexes is a fundamental step in the signal transduction process in response to agonist -induced smooth muscle contraction., A Cdh1-APC/Smurf1/RhoA pathway that mediates axonal growth suppression in the developing mammalian brain., Cannabidiolic acid is an inhibitor of breast cell migration involving its activation of RhoA by inhibition of cAMP-dependent protein kinase., Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl, Data show that the IQ-motif-containing GTPase-activating protein IQGAP1 interacts directly with GTP-bound, prenylated RhoA and RhoC, but not with RhoB., The organization of actin and cytokeratin cytoskeleton and the expression of TCTP, p53,cyclin A, RhoA and actin in HIO180 non-transformed ovarian epithelial cells, and OVCAR3 and SKOV3 ovarian epithelial cancer cells, was studied., vincristine activates GEF-H1/RhoA/ROCK/MLC signaling., RhoA is a PKGIalpha target and direct binding of activated PKGIalpha to RhoA is central to cGMP-mediated inhibition of the VSMC Rho kinase contractile pathway, Low RHOA expression is associated with metastasis of pancreatic cancer., these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy., an unbiased filter approach based on transcriptome-wide profiling identified RHOA as a gene contributing to variation in LDL-cholesterol response to statin, Data show that GnRHR activation affected several cellular markers of locomotion, including actin organization and polymerization as well as active RhoA-GTP levels., Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein, in megakaryocytes, subcellular localization and regulation of MKL1 is dependent on RhoA activity and actin organization, The TMX2-28 breast cancer cell line RhoA dependent, invasive phenotype is mmp2 and mmp9 independent., These findings indicate that the H1N1 virus NS1 protein induces G(0)/G(1) cell cycle arrest mainly through interfering with the RhoA/pRb signaling cascade, thus providing favorable conditions for viral protein accumulation and replication., HMSC are dramatically more sensitive to activation of RhoA., Redox-dependent activation of RhoA/Rho-associated kinase and Src/vascular endothelial cadherin signaling pathways, together with Akt inactivation, contribute to endothelial dysfunction in diabetes., these results suggest that the progression of pancreatic tumors is partially controlled by the balance between Tiam1-rac1 and RhoA., RhoA activation is important in human breast cancer due to its upregulation of ezrin., The control of RhoA can program the motility patterns of living cells and has implications in studying the relationship between cell morphology and motility., findings suggest that iNOS-mediated activation of RhoA appears to be one of the important mechanisms contributing to the deleterious effects of alcohol on intestinal barrier function, we show for the first time cytoskeleton stabilizing effects of the mTOR inhibitor everolimus and establish RhoA signaling as a key mediator in this process., The aim of this study was to examine the expression of ERM (ezrin, moesin) and Rho (RhoA, RhoB and Cdc42) proteins in breast cancer (BC) patients., The RhoA signaling axis, a well known upstream stimulator of SRF action that harbors drugable targets, conveyed androgen-responsiveness to SRF., In breast tumor samples, miR-182 induction is linked to downregulation of MIM, RhoA activation and poor prognosis., The different ways in which RhoA, RhoB and RhoC expression is regulated in cancer and how they play distinct roles in cancer progression is discussed.[Review], Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins., GOLPH3 regulates the migration and invasion of glioma cells though regulation of RhoA., Data indicate that STIM1 plays its role within the thrombin signaling independently of store-operated Ca2+ entry (SOCE) through Orai channels as a signaling component linking the thrombin receptor to RhoA activation and stress fiber formation., Silencing of LRP1B altered the expression of focal adhesion complex-associated proteins, and Cdc42/RhoA activities., Our results indicate that the loss of miR-125a3p-controlled regulation of the RhoA-actomyosin pathway can lead to increased migration of tumor cells because of the upregulation of RhoA expression., Spontaneous RhoA activity at membrane protrusions is spatially associated with closure, but not formation of inter-endothelial gaps, whereas RhoA activity at distant contractile filaments contributes to thrombin-induced disruption of junctional integrity., High glucose levels produced an increase in RhoA activity in podocytes, and this effect was abolished by the knockdown of TRPC6., These results indicate that suppression of the RhoA-mediated pathway might participate in the Thy-1-induced migration inhibition in human umbilical vein endothelial cells., Results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies., In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling., Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity., LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly., CCR4 mediates CCL17 induced cell migration via increased total RhoA and active RhoA protein levels in colon cancer cells., carboxylesterase I controls RhoA methylation, Data indicate that Epac1-Rap1A-RhoA-ROCK signaling affects Cl- secretion via effects on the apical expression of KCNN4c channels., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., These effects were implemented through RHPN2-mediated activation of RhoA., The RhoA/ROCK1 signalling pathway has important roles in the determination of cell fate., These results indicate that Neisseria meningitidis selectively exploits the epithelial microenvironment in order to protect itself from LL-37 via a RhoA and Cdc42 mediated mechanism., This study indicates that the abnormal expression of p57 and RhoA contributes to progression of hepatocellular carcinoma and poor survival of patients., Vaccinia virus F11 promotes viral spread by binding to host myosin-9A and inhibit RhoA signaling., Abeta oligomer increases sortilin gene and protein expression through p75(NTR) and RhoA signaling pathways, nuclear translocation of RhoA in human gastric cancer cell line AGS is via active transportation, a process through importin alpha in a NF-kappaB-dependent manner., The data identify the GEF Bcr as a regulator of RhoA/MAL signaling in keratinocytes, which in turn promotes differentiation through the desmosomal cadherin Dsg1., focal adhesion kinase and RhoA regulate membrane protrusion and invasion and are regulated by integrins, ERK binds to the Rho exchange factor GEF-H1 and phosphorylates it on S959, causing inhibition of GEF-H1 activity and a consequent decrease in RhoA activity., Macrophage and tumor cell contact induce RhoA activity in tumor cells, triggering the formation of actin-rich degradative invadopodia., RhoA and RhoC play different, but clear, roles in ERalpha signaling in breast cancer cells., Increased cytoplasmic localization of p27(kip1) up-regulates RhoA during progression of chronic myeloid leukemia., The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4., a possible role of GPR97 in lymphatic remodeling, FlnA mutations alter the balance between RhoA and Rac1 GTPases activities in favor of RhoA., These results indicate that Wnt5b is involved in the migration ability of OSCC cells through active Cdc42 and RhoA., Zoledronate-attenuated Ang II induced AAA formation by suppression of MMP-2 activity and suppressed vascular inflammation and Ang II-induced Rho/ROCK activities., IKKgamma facilitates RhoA activation via a guanine nucletotide exchange factor, which in turn activates ROCK to phosphorylate IKKbeta, leading to NF-kappaB activation that induced the chemokine expression and cell migration upon TGF-beta1., Results suggest that EGF-induced SMURF1 plays a role in breast cancer cell migration and invasion through the downregulation of RhoA., The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors., Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics., A systematic review of RhoA/Rho-associated coiled-coil containing protein kinase blocking approaches analyzes the impact of bias that may lead to inflated effect sizes and functional locomotor recovery after experimental thoracic spinal cord injury., RhoA.GTP represses mTORC1 signaling upstream of Akt and mTORC2., these observations demonstrate the significance of RhoA/Rho kinase signaling in regulation of TM cell plasticity, fibrogenic activity, and myofibroblast activation., coordinated RhoA-ROCK1 expression and signaling are mediated by hypoxia-inducible factors in breast cancer cells, results demonstrated that p38 and ERK1/2 played crucial positive roles in adipogenesis, and FAK, RhoA/ROCK and cytoskeleton played negative roles, Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process., TBC1D15 is required for the accumulation of RhoA., assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hypertensive and Bartter's and Gitelman's syndrome patients, a model opposite to hypertension, Data indicate that silencing of IAPs, IAP1 IAP2 and XIAP, reduced the TRAP-evoked RhoA activation., a new mechanism of nitration-mediated RhoA activation involved in LPS-mediated endothelial barrier dysfunction, is reported., The RHOA Gly17Val protein, present in Peripheral T cell lymphomas, interferes with RHOA signaling in biochemical and cellular assays, an effect potentially mediated by the sequestration of activated guanine-exchange factor proteins., Impaired RHOA function in cooperation with preceding loss of TET2 function contributes to angioimmunoblastic T cell lymphoma-specific pathogenesis., Data indicate that amyloid beta peptide induces cellular activation through RhoA-dependent modulation of actomyosin, and hence, RhoA could be a potential therapeutic target in Alzheimer's disease., RhoA, but not RhoC was shown to be essential for the anchored phenotype of breast carcinoma cells that accompanied siRNA-mediated loss of syndecan-2., PKGII inhibits RhoA activity by binding to this small GTPase and causing phosphorylation at its Ser188 site., FAP is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation., Migration assays were performed to evaluate CCL17-induced colon cancer cell (HT-29) chemotaxis and RhoA protein levels were quantified., The RHOA mutation encoding p.Gly17Val is a driver mutation in angioimmunoblastic T cell lymphoma., Direct activation of RhoA with recombinant bacterial cytotoxic necrotizing factor y reverted the abnormal phenotype and barrier function of kindlin-2-deficient keratinocytes and skin equivalents., Saphenous vein smooth muscle cells isolated from type 2 diabetics exhibit distinct aberrancies accompanied by reduced levels of RhoA expression and activity., Study demonstrates that increased DGKzeta protein levels in SW620 cells are associated with increased Rho GTPase activity and downstream signaling; silencing of DGKzeta expression in SW620 cells decreased Rac1 and RhoA activity and attenuated cell invasion; DGKzeta silencing also attenuated the invasiveness of PC-3 prostate cancer and MDA-MB-231 breast cancer cells., the relation of G17V mutation of the RHOA gene (RHOA-G17V) to nodal peripheral T-cell lymphoma, analysis of RHOA mutations in diffuse-type gastric carcinoma, ARHGEF3 and RHOA are potential regulators of a number of genes in bone cells, with influences on ACTA2 evident in both osteoblast-like and osteoclast-like cells., Data indicate that dexamethasone inhibition of Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) activity involved Ras homolog family member A (RhoA)-independent signaling pathways., RhoA (and Rac1) were identified as downstream effectors of D1 receptors during the regulation of dendritic morphogenesis., adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation, The significant downregulation of RhoA protein and mRNA expression after UVB irradiation and the modulation of miR-340 expression suggest a key role for miR-340 in regulating UVB-induced dendrite formation and melanosome transport., RhoA is important for maintenance of cell differentiation and RhoB protects cells from malignant cervical neoplasia., our study supports the regulatory role of p120 in airway inflammation and reveals that p120 may modulate NF-kappaB signaling partially through RhoA., Findings suggest that Wnt5a enhances cell migration through activation of Cdc42 and inactivation of RhoA in human corneal endothelial cells., These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion., MTOR regulate EMT at least in part by down regulation of RhoA and Rac1 signaling pathways., Dietary folate affects metastasis through the regulation of the carboxyl methylation of Rho family GTPases RhoA and Rac1., data are presented showing that CD44 could act through RhoA signaling to regulate YAP expression, Inactivation of RhoA due to lack of prenylation leads to Rac1 activation and subsequent priming for IL-1beta secretion., co-expression of Delta-catenin and RhoA was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer, Snail regulates the motility and invasiveness of oral cancer cells via RhoA/Cdc42/p-ERM pathway., These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages., alteration in CD9 expression was sufficient to profoundly disrupt cellular actin arrangement and endogenous cell contraction by interfering with RhoA signaling., Comparison with a structure of the isolated AKAP-Lbc DH domain revealed a change in conformation of the N-terminal 'GEF switch' region upon binding to RhoA, Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells., miR-200b and miR-200c are suppressed in AGE-induced endothelial cell injury, resulting in unregulated RhoA/ROCK2 signaling., control exerted by ERRalpha on RHOA stability is required for directional migration, reduction of RhoA signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma., these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis., metformin impairs Rho GTPases signaling to induce apoptosis via JNK pathway, RHOA inactivation enhances Wnt signalling and contributes to colon cancer metastasis., CCR7 via RhoA/ROCK-Pyk2 cofilin pathway promotes invasion and migration of metastatic SCCHN cells, Upregulation of RHOA is associated with arteriosclerosis obliterans of the Lower Extremities., Despite RhoA and RhoB GTPases are different in their biological roles, no significant difference in immunoexpression of the RhoA and RhoB GTPases in epithelial and mesenchymal structures of parotid., Net1A plays a plays a previously unrecognized, Rho GTPase-independent role in controlling ATM activity and downstream signaling after DNA damage to impact cell survival., RAGE/MT1-MMP axis modified HMBG-1-mediated TF expression through RhoA and Rac1 activation and NF-kappaB phosphorylation in endothelial cells, these observations indicate that increased fibrogenic activity because of dysregulated RhoA GTPase activity in the trabecular AH outflow pathway increases intraocular pressure in a Rho kinase-dependent manner., Sep15 in Chang liver cells regulates the pathway that antagonizes RhoA/ROCK/MLC-dependent non-apoptotic bleb formation., inhibition of p38 MAP kinase attenuated the histamine response in all three EC types. Inhibition of RhoA, ROCK, or MLCK also prevented the histamine-induced decrease in TER in HDMEC., These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge., Lipoxin A4 induces aortic contraction via RhoA/Rho kinase/reactive oxygen species pathway., We have demonstrated that clinically achievable concentrations of zoledronic acid and docetaxel cause a reduction in the prenylation of both H-Ras and Rho A and a reduction of protein movement into the membrane., The knockdown of RhoA prevents proliferation and metastasis in SPCA1 lung cancer cells., DLC3 depletion enhances perinuclear RhoA activity., Annexin A2 is required for the early steps of cytokinesis to set up the RhoA signaling pathway at the cortical ring., High RhoA expression is associated with cancer., Our observations identify a mechanism underlying polarized GOP biogenesis and provide new insights regarding involvement of RhoA in dendritic development and polarization., These data on the role of RhoA/ROCK in regulating cell myogenic differentiation on lasered microchannels substrates may provide a mechanistic insight on human mesenchymal stem cells fate directed by substrate topography., These findings establish a central role for ANXA1 in the cell migration through the activation of NFkappaB, ERK1/2 and RhoA., It was demonstrated that elevated levels of mRNA for RHOA was significantly associated both with loss of methylation in RHOA CpG-islands and methylation in a number of miRNA genes., knockdown of TMEM45A also inhibited cell adhesion as well as cell invasion. More importantly, suppression of TMEM45A notably downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2., ApoE inhibits cerebrovascular pericyte mobility through a RhoA-mediated pathway, Results demonstrated that the miR-200b/200c/429 subfamily inhibited HCC cell migration through modulating Rho/ROCK mediated cell cytoskeletal reorganization and cell-substratum adhesion., under hypoxia conditions, elevated HIF-1alpha seems to up-regulate contactin-1 expression and by this activate RhoA and facilitate migration of cancer cells., 17beta-estradiol induces proliferation of uterine smooth muscle cells in endometriosis through hyperactivation of the estrogen receptor-RhoA/ROCK signaling pathway., AMPK and Akt activation are responsible for the CTRP6-mediated anti-fibrotic effect by targeting RhoA/MRTF-A pathway(, Data indicate that through GTPase-activating proteins ArhGAP29 complex formation Rap1 GTP-binding protein spatially restricts Rho-mediated signaling, which is necessary for endothelial barrier potentiation., Genetic Variants in Caveolin-1 and RhoA/ROCK1 Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population., Cul3 deletion mutations (associated with hypertension), impair ubiquitin ligase activity toward RhoA., Expression of RhoA and Rac1 was absent in fibroblasts of adjacent normal tissue and in compromised lymph nodes. Based on our findings that no significant changes were observed between primary and metastatic lymph nodes, We propose that PrP modulates beta1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin, and through the regulation of ERM-mediated membrane-cytoskeleton linkage., Data show that active GTP binding protein RhoA negatively regulates the heat shock response (HSR) via attenuation of the heat shock transcription factor 1 (HSF1)-heat shock elements (HSE) binding of HSP70 (HSPA1A) promoter., Report occurrence and clinicopathological characteristics of RHOA hotspot mutations in gastric cancer, but found no evidence for a prognostic or growth advantageous effect of RHOA mutations., Blocking the expression of RhoA in colonic tumor cells transfected with pshRNA-RhoA can reduce their invasive and adhesive capabilities., RhoA interacts with and activates TRPC1 and thus stimulates rapid epithelial restitution after injury by inducing Ca(2+) signaling., our results suggest a role for oncogenic RHOA mutation in the development of gastrointestinal cancers., ODAM induced RhoA activity. ODAM-mediated RhoA signalling resulted in actin filament rearrangement, increased cell adhesion and inhibited the migration/invasion of MCF7 cells. These results suggest that ODAM expression maintains their adhesion, resulting in the prevention of their metastasis via the regulation of RhoA signalling in breast cancer cells., Data show that myosin II supports a stable Rho zone at the at E-cadherin junctions., Fbxw7 induces apoptosis and growth arrest and inhibits theepithelial-to-mesenchymal transition (EMT) in part by down-regulating the RhoA signaling pathway., Deoxypodophyllotoxin suppresses gastric tumor vasculature by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation., The complex formation mediated by the Clostridium botulinum C3 exoenzyme ARTT-loop is through the intrinsic plasticity of C3 exoenzyme and RhoA., Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility., We conclude that 2-ME inhibits the pathway RhoA --> ROCK1 --> myosin phosphatase targeting subunit --> myosin light chain, and this likely contributes to the reduced cytokinesis in 2-ME treated HASMCs., Young MetS subjects, between 20 and 40 years old, already have RhoA/ROCK activation, increased oxidative stress markers and endothelial dysfunction., This study not only provides a novel insight into the molecular pathogenesis of adult T-cell leukemia/lymphoma but also highlights a unique role of variegation of heterologous RHOA mutations in human cancers., RHOA G17V mutation is present in a significant proportion of angioimmunoblastic lymphomas and is associated with classic pathologic features of AITL., RhoA-depleted cancer cells exhibited markedly reduced migration and invasion ability in vitro., These data suggest that modulation of RhoA GTPase activity impairs DNA damage repair, increasing HeLa cell radiosensitivity., These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs., knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased, RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing., FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity, Listeria monocytogenes infection could promote host cell apoptosis and down-regulate RhoA expression.,
SP_COMMENT cofactor:Magnesium., domain:The basic-rich region is essential for yopT recognition and cleavage., function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP., PTM:Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage., PTM:Substrate for botulinum ADP-ribosyltransferase., similarity:Belongs to the small GTPase superfamily. Rho family., subunit:Interacts with RGNEF (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation.,