Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
DAVID Functional Annotation Table
Gene Report
Help and Manual

Right-click and select 'Save Target As' to download results Download File
kinase insert domain receptor(KDR) kinase insert domain receptor(KDR) Related Genes Homo sapiens
CYTOBAND 4q11-q12,
GENERIF_SUMMARY vitronectin increased the presence of all four growth factor receptors and most notably, VEGFR-1; in contrast, fibrin decreased all four receptors, especially FGFR-1 and FGFR-2, A potential mechanism involved in hemangioma formation is the alteration of the FLK1 signaling pathway in endothelial and/or pericytic cells., green tea catechins are novel inhibitors of VEGFR-2 activity., Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro., In this study we give evidence of Flt-1 and KDR receptors in platelets., VEGF, Flt1, and Flk1 can be considered as indicators of the malignancy potential of diffusely infiltrating astrocytomas. The expression of VEGF and the two receptors may be affected by the proliferative activity of tumor cells., Constitutive activation of Stat3alpha in brain tumors, CLL B cells consistently express VEGFR2 mRNA; co-expression of angiogenic molecules and receptors suggest autocrine pathways of stimulation., Expression of vascular endothelial growth factor receptor Flk1/KDR is induced by shear stress through the CT-rich Sp1 binding site., KDR plays a key role in regulating the proliferation of HGCC and HVEC., findings implicate altered VEGF and KDR signaling in pituitary tumorigenesis; PTTG stimulation of FGF-2 and VEGF expression in the presence of up-regulated growth factor receptors may account for angiogenic growth and progression of human pituitary tumors, The binding of VEGF to its receptor, KDR, is necessary and sufficient to induce the gene expression profile induced by VEGF., The expression of vascular endothelial growth factor and its receptors KDR and Flt-1 by gastric carcinoma tissues and cell lines was detected to elucidate the molecular mechanism of this growth factor in promoting tumor growth., VEGFR-2 has a role in regulating angiogenesis-related functions [review], transcriptional activation of Flk-1 in endothelial cells requires the interaction between HIF-2alpha and Ets-1, A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of this protein's signaling., Fluid shear stress induced upregulation requires Sp1 transcription factor binding to specific response elements in the 5' regulatory region, Staining for the receptors VEGFR-1 and VEGFR-2 was positive in large lymphoid cells in stage IV non-Hodgkin lymphoma., Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR., These data indicate that activation of vascular endothelial growth factor receptor-2 prevents endothelial cell apoptosis by inhibiting p38 MAP kinase phosphorylation and reducing caspase-3 activity., in humans, TNF induces transactivation between Etk and VEGFR2, and Etk directly activates PI3K-Akt angiogenic signaling independent of VEGF-induced VEGFR2-PI3K-Akt signaling pathway., Altered expression of vascular endothelial growth factor and FLK-1 receptor in chronically hypoxic carotid body., VEGF, VEGFR-1 and VEGFR-2 are concomitantly expressed in pre-B ALL cells. Expression of the receptors is limited to the intra-cytoplasmic compartment and may suggest either internalization or a block in trafficking of the receptor to the surface., changing of transcriptional activity of VEGF gene and its receptor FLK-1 indicates an autocrine mechanism of regulation of angiogenic gene activity in the first step of carcinogenesis--low-grade intraepithelial lesions of the uterine cervix, Specific VEGFR2 expression, examined in 27 B-CLL samples, was positive in 26 of them. The VEGF transduction pathway may be very active in CLL cells. Both its paracrine & autocrine pathways may contribute to their enhanced survival., The expression of VEGF and KDR correlates highly with the normal ocular vascularization in humans, Intact caveolae are required for the VEGF/VEGFR-2-mediated MEK/ERK signaling cascade., phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF, KDR is constitutively phosphorylated and located at the nucleus of VEGF-producing leukemias; a KDR-specific intracellular inhibitor failed to block KDR nuclear IMPORT, but inhibited the constitutive activation of MAPK/Erk and PI3-kinase/AKT pathways, the level of sVEGFR-2 is lower in active systemic lupus erythematosus than in inactive disease, maximal P-selectin translocation and subsequent neutrophil adhesion was mediated by VEGF-A(165) on the activation of VEGFR-2/NRP-1 complex and required PAF synthesis., Our data support a role for KDR in oviduct angiogenesis., VEGF receotor signaling regulates survival signals in CLL cells and that interruption of this autocrine pathway results in caspase activation and subsequent leukemic cell death., Tgf-beta mediated repression of flk-1/KDR and mediated repression of flk-1/KDR and VEGF signaling involves the inducible formation of inhibitory Hex-GATA signaling Hex-GATA involves the formation of Hex-GATA complexes., Shb binds to tyrosine 1175 in the VEGFR-2, which regulates VEGF-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner, Nedd4-mediated vascular endothelial growth factor receptor-2 degradation is prevented by Grb10, Data suggest that periostin-mediated angiogenesis derives in part from the up-regulation of the vascular endothelial growth factor receptor Flk-1/KDR by endothelial cells through an integrin alpha(v)beta(3)-focal adhesion kinase signaling pathway., PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3, vascular endothelial growth factor (VEGF) is strongly expressed in villous cytotrophoblast cells and subsequently in Hofbauer cells while its receptors Flt-1 and Flk-1 are found on vasculogenic and angiogenic precursor cells, In chronic lower limb ischemia, growth factor-1 (IGF-1) and IGF-2, were upregulated in atrophic and regenerating myocytes together with attenuated HIF, VEGF, and VEGFR-2 expression in the same cells., Increased expression of KDR is associated with an aggressive angiogenic phenotype in melanoma., activation of the P2Y(2)R induced rapid tyrosine phosphorylation of vascular endothelial growth factor receptor (VEGFR)-2 in human coronary artery endothelial cells, VEGFR2 initiates a clonogenic response in myeloid leukemia cells that is PI3-kinase dependent., VEGFR2 mediated phosphorylation of focal adhesion kinase is regulated by heat shock protein 90 and Src kinase activities, Inhibition by flk-1 kinase inhibitor SU1498 and failure of placental growth factor (PlGF) to up-regulate DAF confirmed the role of VEGF-R2 in VEGF-mediated DAF up-regulation., VEGF(165)-induced phosphorylation of KDR and PLCgamma was partially inhibited by PF-4, VEGF and its receptor, KDR, genes contributed to the development of coronary artery lesions in Kawasaki disease patients., VEGFR-3 needs to be associated to VEGFR-2 to induce ligand-dependent cellular responses, there was no significant correlation between VEGF and VEGF-R2 expression. VEGF-R2 expression was significantly increased on endothelial cell (, The VEGFR2, through interaction with VEGF, regulated adhesive and migratory properties of the cancer cells., Axl stimulation by GAS6 results in inhibition of the ligand-dependent activation of vascular endothelial growth factor (VEGF) receptor 2 and the consequent activation of an angiogenic program in vascular endothelial cells, NRP-1 modulates VEGFR-2 signaling-dependent mitogenic functions of VEGF and regulates endothelial cell adhesion to extracellular matrix proteins independently of VEGFR-2., These data support the involvement in melanoma growth and survival of a VEGF-dependent internal autocrine loop mechanism, at least in vitro., The majority of embryonic stem cells with the potential to differentiate into osteoclasts expressed Flk-1., the activation of VEGFR-1 and VEGFR-2 heterodimer (VEGFR-1/R-2) is essential for PGI(2) synthesis mediated by VEGF-A(165) and VEGF-A(121), which cannot be reproduced by parallel activation of VEGFR-1 or -2 homodimers with corresponding agonists [VEGFR2], Blood levels correlate with lymph node involvement in colorectal cancer., regulatory mechanisms involved in the attenuation of VEGFR-2 activation is mediated by nonclassical Protein Kinase C and the presence of serine sites in the carboxyl terminal of VEGFR-2, VEGFR2 may be involved in the transcriptional regulation of T-cell lymphoma., VEGFR-2 expression, co-localized in the cytoplasmic and nuclear membrane, is associated with progression towards invasive melanoma, Phosphorylated ERK1/2 was further associated with the presence of VEGFR2 (cohorts II and III) and the degree of phosphorylated Ets-2, indicating in vivo, a signalling cascade from VEGFR2 via ERK1/2 to Ets-2 phosphorylation, Targeting the release of VEGF from tumor epithelial cells as well as blocking interactions between VEGF and VEGFR-2 on both endothelial and tumor epithelial cells may facilitate the development of antiangiogenic therapies for breast tumors., human VEGFR-2 promoter is functionally counter-regulated by TFII-I and TFII-IRD1., key role of KDR in megakaryopoiesis, decrease in expression is caused by C-reactive protein, KLF2 is a regulator of VEGFR2/KDR and has a role in regulating angiogenesis, role in modulating tumor neovascularization in conjunction with interleukin-3 receptor, dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis, assessed the role of VEGF and its receptors in osteoclastogenesis, in vitro, by culturing osteoclast precursors in the presence of VEGF, VEGF receptor-specific ligands, and blocking antibodies to VEGF receptors, Up-regulation of VEGF-A receptor VEGFR-2 in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability., An immunohistochemical analysis of VEGFR2 in pituitary adenomas was made., Blockade of either VEGF or its receptors with neutralizing antibodies significantly reduced cell viability and increased apoptosis levels of the VEGFR-positive thyroid tumour cell line., vascular endothelial growth factor receptor-2 phosphorylation is inhibited by delphinidin, LPC-induced Flk-1/KDR transactivation via c-Src may have important implications for the progression of atherosclerosis, Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1., Regulation of VEGF(165) signaling through the VEGFR-2 complex in response to cigarette smoke exposure in vivo, and in smokers with and without chronic obstructive pulmonary disease., VEGF and its receptors many play key roles in the growth, invasion and metastasis of human laryngeal carcinoma cells., New VEGFR2 containing cell subpopulation,which is apparently a precursor classical endothelial progenitor cells more potent with respect too homing and vasscular repair., We conclude that neoplastic cells show a variable expression of total and phosphorylated KDR in the nucleus., This study describes the first specific antagonist of VEGF-A165 binding to NP-1 and demonstrate that NP-1 is essential for optimum KDR activation and intracellular signaling., We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression., Phosphorylated KDR expression was significantly associated with poor prognosis., Sp3 and Sp4 cooperatively interact with ERalpha to activate VEGFR2, In conclusion, EC death induced by high shear stress and VEGFR blockade leads to the production of factors, in particular TGF-beta1, that activate VSMC proliferation., haplotype analysis showed that atopy prevalence was strongly associated with a haplotype (AGAG) of VEGFR2, Immunohistochemical staining showed that VEGF-R2 were expressed in epithelial, stromal and endothelial cells., These results suggest that VEGFR2 cannot only be targeted by receptor tyrosine kinase inhibitors but also by drugs that downregulate Sp proteins or block Sp-dependent transactivation., In this study, we demonstrate that 1121B Fab is able to strongly block KDR/VEGF interaction, resulting in potent inhibition of an array of biological activities of VEGF, including activation of the receptor and its signaling pathway., Vascular endothelial growth factor165 (VEGF165) and semaphorin3A (SEMA3A) elicit pro- and antiangiogenic signals respectively in endothelial cells (ECs) by binding to their receptors VEGFR-2, neuropilin-1 and plexin-a., VEGF and VEGFR-2 may have a role in progression of gastric cancer, NRP1 expression and its GAG modification post-transcriptionally regulate VEGFR2 protein expression., illuminate an important mechanism for notch/HESR1 regulation of VEGF-induced angiogenesis, VEGFR-1 and VEGFR-2 have roles in differentiation of hepatocellular carcinoma, Gab1 thus appears as a primary actor in coupling VEGFR-2 to PI3K/Akt, recruited through an amplification loop involving PtdIns(3,4,5)P3 and its PH domain, REVIEW, overexpression of VEGF, its receptors flt-1, KDR/flk-1 and TGF-beta interaction may play an important role in the ovarian cancer biology, with potential effects on tumor growth and angiogenesis, VEGF receptors are found on plasma cells from all groups of patients with multiple myeloma with the lowest expression on plasma cells from normal individuals, Thus, vascular endothelial cadherin limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments., Taken together these data show that VEGF-A(165)b has attenuated signaling potential through VEGF receptor 2 defining this new member of the VEGF family as a partial receptor agonist., Endothelial cell tissue transglutaminase (tTG) might be involved in modulation of the cellular response to VEGF by forming an intracellular complex with VEGFR-2, and mediating its translocation into the nucleus upon VEGF stimulation., perlecan secreted by VEGF165-stimulated endothelial cells may be involved in the regulation of cellular behavior during angiogenesis, VEGFR-2 expressed on HaCaT cells plays a crucial role in VEGF-mediated regulation of cell activity, SCID mice bearing xenografts of transfected cell lines were used to assess the effect of VEGF overexpression and the effect of VEGF receptor (VEGFR) 2 inhibition on soft tissue sarcoma growth., VEGF regulation of angiogenesis may in part be due to enhanced proliferation of VEGFR-1 and VEGFR-2, Signaling via VEGFR-2 is involved in prostate lymphatic endothelial cell tube formation, migration, & proliferation in vitro. Blockade of VEGFR-2 significantly reduced tumor-induced activation of LECs., These results suggest that the expression of VEGFRs and NRPs on keratinocytes may constitute important regulators for its activity and may possibly be responsible for the autocrine signaling in the epidermis., in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only, Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between receptor monomers through the membrane-proximal immunoglobulin-like domain 7., Endometrial blood vessels possess a discrete morphology that is characterized by endothelial gaps, and these gaps are more pronounced in women with menorrhagia and overexpression of VEGFR2., corecruitment of c-Cbl and PLCgamma1 to VEGFR-2 serves as a mechanism to fine-tune the angiogenic signal relay of VEGFR-2, Mechanisms other than genetic variation may downregulate expression or function of the VEGFR2 receptor in patients with ALS., Taken together, these results lend great support to use PDGFRbeta antagonists in combinations with other antitumor and/or anti-angiogenic agents in the treatment of a variety of cancers., VEGF receptor KDR was expressed in ovarian cancer cells, and CDDP-inhibited VEGF expression was linked with cellular apoptosis, which was rescued by VEGF treatment., These findings provide evidence for a novel cooperative interaction between VEGFR2 and RET that mediates VEGF-A functions in ureteric bud cells., VEGFR2 enhances VEGF(165), but not VEGF(121) binding to NRP1., Leukemia patients showing parallel activation of the studied proteins trended to exhibit higher incidence of fatal outcome., High levels of VEGFR-3 and -2 seem to contribute to the etiology of lymphangiomas., determined the expression pattern of VEGF splice variants in NSCLC and its correlation with the clinicopathological characteristics of tumors, ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell, Increased expression of Flk-1 may be involved in sinusoidal capillarization and the increased numbers of unpaired arteries in capillarized areas with increased numbers of unpaired arteries in dysplastic liver nodules., c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., PKA and VEGFR2 converge at the MEK/ERK1/2 pathway to protect serum starved neuronal cells from a caspase-dependent cell death., increase in VEGF in AR with and without asthma despite a higher Flk-1 in AR patients with asthma may be a possible explanation for the presence of angiogenesis in the airway wall in patients with asthma but not in those with pure AR., myoferlin forms a complex with dynamin-2 and VEGFR-2, which prevents CBL-dependent VEGFR-2 polyubiquitination and proteasomal degradation., KDR polymorphisms may serve as novel genetic markers for the risk of coronary heart disease., studied circulating CD31- and/or CD34-positive cell populations with a low to moderate VEGFR2 expression in human volunteers and cancer patients., Vascularization and VEGF and Flk-1 expression are significantly higher in deeply infiltrating endometriosis affecting the rectum., VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway, HARP negatively affects diverse biological activities in C6 glioma cells, mainly due to binding of HARP to VEGF, which may sequester secreted VEGF from signalling through VEGFR2., isolation and purification of Flk-1cells with mesenchymal stem cell characteristics from bone marrow of myeloma patients., points to VEGFR2 transactivation as an important signaling pathway used by chemokines such as IL-8/CXCL8, Expression profile of total VEGF, VEGF splice variants and VEGF receptors in the myocardium and arterial vasculature of diabetic patients., VEGFR2 up-regulation had no effect on VEGF-induced cell proliferation, but significantly enhanced endothelial progenitor cells migration and pseudotubes formation dependent on integrin alpha(6) subunit overexpression., Within mdx mice, an animal model of DMD, adipose tissue-derived Flk-1(+) MSCs (AD-MSCs) homed to and differentiated into cells that repaired injured muscle tissue., Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR., expressed in the microvascular endothelial cells of both primary and young permanent teeth, Increased levels of Factor VIII occurred in the precursors of cardiac myocytes, smooth muscle and endothelial cells in normal and post-ischemic hearts., Support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability., Preeclampsia and SGA are associated with low maternal plasma concentrations of soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), These proteins have an essential molecule required for promoting the disruption of endothelial cell-cell contacts and paracellular permeability., Overall, these results indicate that HDAC6 and HDAC10 play important roles in Hsp-mediated VEGFR regulation., a maximal bout of exercise induces a significant shift in CD34+ cells toward CD34+/KDR+ cells, Gal-1 can directly bind to NRP1 on endothelial cells, and can promote the NRP1/VEGFR-2-mediated signaling pathway as well as NRP1-mediated biological activities., The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation., Surveillance of VEGFR-2 levels to predict chemotherapy response is not useful., the temporal expression of TNF is critical, Found in normal and neoplastic thymus tissue., Intensity of VEGFR-2 in odontoblasts increases from cap stage to late bell stage., VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier., complex interaction between sphingosine-1-phosphate and VEGFR-2 in ML-1 thyroid follicular cancer cells, particularly in regulating migratory responses, the 167-181 region of VEGFR-2 has an important role in the stimulation of CD4(+) T cell responses to VEGFR-2 protein, VEGFR-2 levels were associated with poor tumor differentiation in patients with gastric adenocarcinoma, binding of Neuropilin-1 to VEGFR-2 requires the PDZ-binding domain of neuropilin-1, vascular endothelial growth factor, receptor KDR and p53 protein are expressed in transitional cell carcinoma of the bladder, PTHrP (107-139) interacts with VEGFR-2 to promote human osteoblastic cell survival by a mechanism involving Runx2 activation., sVEGFR-2 levels were not significantly increased in patients with liver cirrhosis., in vascular endothelial cells the binding of adrenomedullin to its AM1 receptor could trigger a transactivation of the VEGFR-2 receptor, leading to a signaling cascade inducing proangiogenic events in the cells., These results are consistent with a potential autocrine role of the VEGF-VEGFR2 (KDR) interplay as a factor contributing to malignant astrocytoma growth and radioresistance., The tumor uptake of 64Cu-DOTA-VEGF measured by small-animal PET imaging reflects tumor VEGFR-2 expression level in vivo., VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling., matrix-controlled TCPTP phosphatase activity can inhibit VEGFR2 signalling, and the growth, migration and differentiation of human endothelial cells, VEGF-R2 expression is significantly increased in port-wine stains, suggesting that VEGF-R2 could contribute to the pathogenesis of PWS by inducing vessel proliferation, vasodilation, or both., Normalization of the constitutive VEGFR2 signaling in hemangioma endothelial cells with soluble VEGFR1 or antibodies that neutralize VEGF or stimulate beta1 integrin, correlation between expression of VEGF and p27(Kip1) was observed in bone marrows from patients with acute myeloid leukemia, Achieving optimal therapeutic outcomes, the scheduling of radiotherapy and antiangiogenic therapy requires patient-specific post-treatment monitoring of the VEGFR2 pathway., glioma cells enhance EPC angiogenesis via VEGFR-2, not VEGFR-1, mediated by the MMP-9, Akt and ERK signal pathways, LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to factor HIF1alpha and HIF2alpha expression. LDH5 expression is linked with activated VEGFR2/KDR expression, Results show a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in primary breast neoplasms during neoadjuvant therapy, and suggest that VEGFR2 levels may indicate the level of lymphatic metastasis., a distinct VEGFR-2-mediated pathway promoting tumor growth through autocrine mechanisms., The expression of VEGF-A, VEGFR-1, VEGFR-2, and VEGFR-3 in was higher in peritumoral liver tissue, while VEGF-C expression was higher in tumor., High VEGFR-2 in stromal vessels is associated with gastric cancer., VEGFR2 was significantly decreased in human colonic microvascular endothelial cells under hypoxia. In contrast, the responses of VEGFR2 levels to hypoxia in human umbilical vein endothelial cells were variable, that is, either unchanged or up-regulated., No significant correlations between the levels of VEGFR2 in the blood and renal cancer tissue were found., VE-PTP, regulates VEGFR2 activity thereby modulating the VEGF-response during angiogenesis., no activating mutations in the tyrosine kinase domain of the VEGFR-2 were identified in 66 hepatocellular carcinoma samples, In malignant pleural mesothelioma cells, plexin-A1 and VEGF-receptor 2 (VEGF-R2) are associated in a complex which are involved in survival pathways., VEGFr2 up-regulation is a feature of poor differentiation and tumor progression., Vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 expression., secretion and the regulation of the secretion of sVEGFR-2 by microvascular endothelial cells derived from the tissue of benign prostatic hyperplasia, A local defect of both VEGF transmembranous receptors (KDR and Flt-1) in the endometrium covering the septal area may be responsible for the clinical comportment of this mullerian anomaly., In breast cancer patients, Flk-1/KDR was strongly expressed in vascular endothelial cells., chronic hypoxia attenuates VEGF-stimulated signaling in coronary artery endothelial cells by specific downregulation of KDR expression, extracellular RNA serves an important cofactor function to engage VEGF for VEGF-R2-dependent signal transduction, Soluble VEGFR-2 was lower in Dengue Fever and Dengue Hemorrhagic Fever patients compared to study controls., these findings suggest that CCL23 results in up-regulation of KDR/flk-1 receptor gene transcription and protein expression and that KDR/Flk-1 up-regulation induced by CCL23 may contribute to potentiation of VEGF action in angiogenesis., REVIEW, In contrast to sVEGFR-1, sVEGFR-2 was significantly decreased in both normal colonic tissue and human colon cancer tissue under hypoxic conditions., expressionin cancer tissue has no prognostic impact in non-small cell lung cancer patients, 50%., Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells; Endothelial cell migration was increased by Rab5a depletion but decreased by Rab7a depletion, KDR/CD34 and IL-10 are major independent predictors of 30-day major adverse clinical outcome in ST-segment elevation acute myocardial infarction patients undergoing primary coronary angioplasty., We have identified a VEGFR2/NOX4 regulatory pathway by which Ox-PAPC controls important endothelial functions., The presence of the VEGF-A receptors, particularly in the granulosa cells, suggests that VEGF-A might be involved in proliferation initiation of primordial follicles or play an as yet unknown role in human preantral follicles., The aim of the study was to assess the usefulness of soluble angiogenesis markers such as endoglin and VEGFR2 in gastric cancer patients and to compare these results with those of VEGF levels., 271 G>A polymorphism of the KDR gene is related to transcriptional regulation in patients with non-small cell lung cancer., Repression of the small Rho GTPase Rac1 in human endothelial cellsseems to be an additional critical molecular mechanism in the regulation of VEGFR2 expression., VEGF-2 gene variants may serve as novel genetic markers for the risk of stroke and its recurrence., In conclusion, we have shown for the first time that variation in the VEGFR2 gene is associated with elite athlete status, endurance performance of female rowers and muscle fibre type composition., (-)-Epigallocatechin gallate can exert, at least in part, its growth-inhibitive effect on HCC cells by inhibiting the VEGF-VEGFR axis, analysis of the experssion of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma, VEGFR2, but not VEGFR1, is responsible for the release of von Willebrand factor., Abnormal expression of VEGF and Flk-1/KDR may be the initiating factor of angiogenesis in the process of breast hyperplasia-atypical hyperplasia-breast cancer., Study provides novel insights for angiogenesis mechanisms in pediatric solid malignancies for which antiangiogenic targeting of VEGFR2+-BMD progenitors could be of interest., The present study evaluated the epigenetic gene silencing of VEGF and VEGFR genes in cancer tissues., Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors., Results manifested that VEGFR2-based DNA chimeric vaccine could be developed as a promising approach for tumor immunotherapy., VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance, High cytoplasmic KDR expression in diffuse large-cell lymphoma correltaed with poor survival., These data establish a novel role for SHP-2 phosphatase in the dopamine-mediated regulation of VEGFR-2 phosphorylation., VEGFR2-PLCgamma1 signal relay gives rise to the unique function of VEGFR2, thus enabling endothelial differentiation from vascular progenitors., VEGFR2 was expressed in the majority of pre-B-ALL bone marrow samples., To study the role of dimerization in receptor activation we created a series of dimerization-promoting transmembrane domain (TMD) mutants lacking the extracellular domain. Dimerization is necessary, but not sufficient, for receptor activation., There is strong evidence that VEGF and its receptors are involved in the onset of sarcoidosis and influence its course., Data suggest that the coreceptor function of CD44v6 for c-Met and VEGFR-2 is a promising target to block angiogenesis in pathologic conditions., Medullary thyroid carcinoma metastases showed a higher VEGFR2 expression than primary tumors., KIT, PDGFRA, and VEGFR2 amplifications were all present in 4% of Medulloblastomas and primitive neuroectodermal tumor and KIT amplification was associated with concurrent PDGFRA and VEGFR2 amplifications, there is a novel relationship between glucose exposure and expression at the transcriptional and translational levels of VEGF, VEGFR2, and NRP-1 in epithelial ovarian carcinoma cells., A statistically significant increase of sVEGF-R2 and significant decrease of sVEGF-R1 were observed in the subgroup of newly diagnosed SLE patients as compared to the control subjects., Data demonstrate that VEGF-induced angiogenesis requires inverse regulation of VEGFR1 and VEGFR2 in tumor-associated endothelial cells., alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, Data show that EMMPRIN up-regulate hypoxia-inducible factor-2alpha, VEGFR-2, and the soluble forms of VEGF in endothelial cells, thus directly regulating the angiogenic process., Data show that patients and controls had similar sVEGFR-2 levels, but VEGF levels were lower and sVEGFR-1 higher in patients with autism., These findings suggest that NRP-1-VEGFR-2-complex formation may contribute to effective cellular functions mediated by VEGF(165) in megakaryocytic cells., Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients., KDR may be amplified in fibrosarcoma of bone., VEGFR2 gene polymorphism correlates with cytogenetic response, treatment failure following imatinib therapy for chronic myeloid leukemia., VEGFR-2 is significantly reduced in association with pre-eclampsia., VEGFR-2 was significantly upregulated by alpha-v suppression in HUVEC & downregulated in HMVEC at mRNA & protein levels. Suppression of alpha-v can either augment or inhibit VEGFR-2 levels & VEGF-induced proliferation in EC from different vascular beds., showed that vascular endothelial growth factor receptor 2 (VEGFR2) is selectively expressed by FOXP3high but not FOXP3low Treg., VEGFR1, VEGFR2, and PDGFRalpha are over-expressed in K-ras mutated colorectal adenocarcinoma., The VEGFR-2 gene variants may serve as novel genetic markers for the risk of hemorrhagic stroke., EPO induction of NO is dependent on the betaC-R and VEGF-R2; VEGF induction of NO is dependent on the expression of the betaC-R, and that the betaC-R and VEGF-R2 interact, a novel function for VEGF and KDR in CD45RO+ memory T cell responses, This study is the first to investigate the association of VEGFR-2 polymorphisms with age-related macular degeneration (AMD) and evaluates VEGFA genetic variants in the largest neovascular AMD cohort to date., Metronomic dalCMP is safe, well tolerated, and clinically active in metastatic breast cancer, but there was no correlation between response and VEGF, sVEGFR-1, or sVEGFR-2 levels., VEGFR2+ cell count around poorly differentiated tumors was significantly higher than that around well differentiated tumors, Objective antitumor activity and antiangiogenic effects were observed over a wide range of dose levels, suggesting that ramucirumab may have a favorable therapeutic index in treating malignancies amenable to VEGFR-2 inhibition., VEGF might be involved in several aspects of neural cell development, including migration, differentiation, synaptogenesis, and myelination, and VEGFR-2 might be one of the main receptors that mediate these processes., Ala+TIMP-2 selectively alters the phosphorylation pattern of VEGFR-2 after VEGF-A stimulation and disrupts the downstream activation of PLC-gamma, Ca(+2) flux, Akt, and eNOS, as well as decreasing cGMP levels., farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades, Data show that that among known sunitinib targets, only platelet-derived growth factor receptor-beta and vascular endothelial, phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination, High VEGFR2 expression, EGFR expression, and EGFR gene copy number were significantly correlated to triple-negative breast cancer, an impact of two SNPs in the VEGRF-2 gene on neoangiogenesis in patients with colorectal cancer, Results provide significant insights into the structural features that determine the high affinity and specificity of VEGF/VEGFR interactions., amniotic fluid concentration not lower in preterm premature rupture of membranes, Pregnancies with a fetal death, at the time of diagnosis, are characterized by a decrease in the maternal plasma concentration of sVEGFR-2, but an increase in the amniotic fluid concentration of this protein., A dysregulation of the placental expression of the VEGFR-2 related to the different degrees of the gestational periods., VEGFR2 expression was significantly reduced in all cases of preeclampsia compared to control placentas., Studies show the design and development of dual VEGF-R2/PLK1 inhibitors., We provide evidence for the downregulation of the lymphangiogenesis inhibitor sVEGFR-2 in metastatic neuroblastoma stages, Data show that VEGFR2 RNA interference induced an induction of more aggressive cellular behavior in transfected EOC cells., Ginsenosides Rg3 can down-regulate the expressions of KDR and VEGF in human lung squamous cancer SK-MES-1 cells., VEGF-A, VEGFR1 and VEGFR2 have roles in events occurring at the invasive tumour front, Both VEGFA and VEGFC potently induce formation of VEGFR2/-3 heterodimers., VEGF release and the subsequent activation of VEGF receptor 2 link loricrin gene mutations to rapid cell proliferation in a cellular model of loricrin keratoderma., Cells expressing VEGFR2 (in combination with CD34 or CD133) are significantly increased during second and third trimesters of uncomplicated pregnancy compared to the first trimester but are reduced in women with preeclampsia., The expression of pVEGFR-2 might be a novel predictive prognostic marker for patients with pancreatic cancers, especially at clinical stage IIA., Radix Ginseng and Radix Notoginseng formula can promote HUVEC proliferation and secretion of VEGF and VEGFR2., not only the existence of a glomerular paracrine proangiogenic, but also an autocrine role of the VEGF-VEGF-R system in diseased podocytes., Results suggest that pathogenic hantaviruses disrupt fluid barrier properties of endothelial cell adherens junctions by enhancing VEGFR2-VE-cadherin pathway responses which increase paracellular permeability., We expand previous data on the association of AMD with VEGF-A gene variations and identify for the first time an association with variations in the KDR gene., expression of sVEGFR-2 may explain the inverse relationship between VEGFR-2 expression and PI3K/Akt signaling, provide evidence that soluble VEGF receptors promote mural cell migration through a paracrine mechanism involving interplay in ECs between VEGF/VEGFR-2 and S1P/S1P1 pathways that leads to endothelial nitric oxide synthase activation, Studies indicate that inhibition of the VEGF/VEGFR pathway may be a rational and effective therapy for certain patients with angiosarcoma, EHE, and HPC/SFT., Data hypothesize that VEGFR-2 forms a signaling complex with S1P(1) and and protein kinase C-alpha , evoking bidirectional signaling regulating both ERK1/2 phosphorylation and haptotaxis of ML-1 cells., A lower maternal plasma sVEGFR-2 concentration precedes the development of preeclampsia, both term and preterm., Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells, Findings demonstrate that induced expression of KDR on subsets of T cells, and locally expressed VEGF, facilitate EC-dependent lymphocyte chemotaxis., Data demonstrate that the mechanosignaling cascade is initiated by vascular endothelial growth receptor-2 (VEGFR2) activation., The VEGFR-2 is primarily localized to, and significantly upregulated on, tumor vasculature (blood and/or lymphatic) supporting the majority of solid cancers., VEGF-A, VEGFR-1, and VEGFR-2 immunoreactive proteins are overexpressed in medullary thyroid carcinoma lesions and might be implicated in tumor progression, Single Nucleotide Polymorphisms in VEGFR2 gene is associated with hypertension and hand-foot skin reactions in therapy related cancer., aneurysm formation associated with a loss of expression of VEGFR1, moderate expression of VEGFR2 and high concentration of nitrate., hypercapillarization previously described in the placenta of women with mild hyperglycemia may result from the downregulation of VEGFR- 1, thereby enhancing VEGF/VEGFR-2 interaction and the activation of angiogenesis., Co-expression of VEGF and its receptor VEGFR-2 (KDR) was present in MPNST cell lines suggesting an autocrine loop., Immunohistochemical evaluation of VEGF and VEGFR-1 overexpression may be a useful marker for predicting 5-year disease free survival in endometrioid endometrial cancer., Inhibition of VEGFR2 augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction., a novel mechanism by which EMMPRIN promotes tumor progression through HIF-2alpha/VEGFR-2 mediated mechanism, Vascular endothelial growth factor stimulates osteoblastic differentiation of cultured human periosteal-derived cells expressing vascular endothelial growth factor receptors, Vascular Endothelial Growth Factor Receptor-2 crosstalk with Muscarinic acetylcholine receptors to enhance mTOR activity but signal divergent effects on survival through alternate mechanisms., results suggest that VEGF is involved in hemangioma angiogenesis but that soluble VEGFRs marginally influence this process; lower serum levels of sVEGFR1 in hemangioma patients indicate the possible dysregulation between VEGFR1 and VEGFR2 receptors, Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47, The level of VEGFR2 expression in patients with a background of breast cancer in pregnancy or lactation was significantly higher than in age-matched patients with sporadic breast cancer at the same stages of the disease., Results suggest an important role of VEGFR-2 in Granulos Cell Tumor (GCT) pathology & support the possibility of applying novel VEGFR-2-targeted treatments to patients with GCT., the ability of soluble forms of perlecan domain i to modulate vascular endothelial growth factor-165 (VEGF165) enhanced capillary tube-like formation, and VEGF receptor-2 phosphorylation, MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src., Importance of syntaxin 6 in the maintenance of cellular VEGFR2 levels., The immediate micromechanical stiffening is dependent on activation of the vascular endothelial growth factor receptor (VEGFR)-2, because inhibition of the receptor abrogates the micromechanical response., Data show that VEGFR2 is up-regulated on vascular endothelial cells and epithelial cells in mouse and human CAC., The proliferation of A549 cells is inhibited significantly and the apoptosis of cells is induced by inhibiting VEGFR2 expression with RNAi., BIBF 1120, a triple angiokinase inhibitor, has an effect on VEGFR2+pTyr+ peripheral blood leukocytes, Suggest that while heterogeneous expression of VEGFR2 is a feature of human tumors, it may not affect response to low dose metronomic cyclophosphamide treatment and possibly other anti-angiogenic approaches., VEGFR-2 expression was significantly correlated with tumor size, histological grade and distant metastasis of papillary renal cell carcinoma., Histological analysis demonstrated an increase in the number of blood vessels and expression of CD34 and vascular endothelial growth factor in hepatocellular carcinoma tissue compared to adjacent liver tissue, VEGFR1, Report age-related differences in the expression of VEGFR-2 in the wall of varicose veins of women., Inhibition of VEGFR2 and Src kinases blocks ANDV-induced endothelial cell permeability., after VE-cadherin induction by DMP1, DMP1 inhibited VEGFR-2 phosphorylation and Src-mediated signaling; DMP1 is identified as a new specific inhibitor of VEGF-induced angiogenesis, this study provides little evidence that VEGF and VEGFR2 polymorphisms are important for glioblastoma survival., Phosphorylated VEGFR-2 is detected on endothelial cells in paediatric pilocytic astrocytoma, Data show that high serum VEGF levels are closely related to the activation status of the VEGFR2/KDR receptor in cancer cells, indicating a stimulatory effect of serum VEGF on the VEGF pathway contributing to tumor progression., Reduced serum VEGFR-2 is associated with gastric cancer., Data sugggest that The inhibition of EGFR and VEGFR2 by vandetanib and its tremendous in vivo antitumor activity against ATC make it an attractive candidate for further preclinical and clinical development for the treatment of this cancer., the VEGF/KDR system jointly contributes to recurrent miscarriage in Taiwanese Han women, During development of undamaged human forebrain, VEGF is always expressed in neurons, astrocytes and neovessel walls, contrary to VEGFR-2, which is only expressed in dispersed astrocytes., Data suggest that targeting VEGFR-1 or VEGFR-2 expressing cells is effective in controlling the osteoblastic progression of PCa in bone., amplification of PDGFRA, KIT and KDR may be implicated in the pathogenesis of a small fraction of both subtypes of glioblastoma, High articular levels of the angiogenetic factors VEGF and VEGF-receptor 2 as tissue healing biomarkers after single bundle anterior cruciate ligament reconstruction., These data show targeting VEGFR-2 outside of the ligand binding domain results in potent inhibition of VEGFR-2 signaling and inhibition of angiogenesis in vitro and in vivo., Inhibition of VEGFR2 kinase with a specific Inhibitor, protein tyrosine kinase inhibitor II (PTKi-II), does not affect capillary-like structure formation., bronchial washing VEGFR2 levels are correlated to overall survival in non-small cell lung cancer patients, VEGFR-2 contains a unique PEST domain-like sequence that regulates the degradation of VEGFR-2 and the ubiquitination of VEGFR-2, which promotes VEGFR-2 degradation by serving as a recruitment site for the F-box-containing ubiquitin E3 ligase beta-Trcp1., Decreased expression of VEGFR-2 is associated with angiosarcoma., Serum VEGFR-2 levels were significantly decreased from gestational hypertension to eclampsia groups as compared with the control level., The density of microvascularization was assessed using CD34 monoclonal antibody (hot spot technique), the expression of angiogenic factors VEGFR, EGFR and COX-2 were determined in tumor biopsies by specific immunohistochemistry techniques, VEGF directly suppresses T cell activation via VEGF receptor type 2., Low VEGFR-2 expression is associated with response to therapy in metastatic renal cell carcinoma., can be used as an independent prognostic biomarker in combination with VEGF-A in advanced non-small-cell lung cancer, Medium and high expression of both F1+2 and VEGF, DC electric stimulation selectively regulates production of some growth factors and cytokines important for angiogenesis through a feed-back loop mediated by VEGF receptors., VEGFR2 receptor tyrosine kinase undertakes a constitutive recycling pathway between the peripheral endosomes and cell surface and this exists in both vascular and non-vascular cells., Micro RNA 200b (miR-200b) negatively regulates VEGF signaling by targeting VEGF and its receptors, Flt-1 and KDR, acting as an angiogenesis inhibitor., Our data establish a distinct role of NRP-1 in VEGFR-2 signaling and reveal a general mechanism for the function of coreceptors in modulating receptor tyrosinase kinase signal output, High VEGFR2 is associated with recurrence in hepatocellular carcinoma., endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic activity, Report Flk-1 production in mouse quadriceps muscle using adeno-associated virus vectors., Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors provides molecular basis for dual targeting of tumoral vasculature., findings show VEGFR-2 and VEGFR-3 expression are markers of a poor prognosis in patients with surgically resected colorectal adenocarcinoma, whereas EGFR has a minor influence, Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-alpha, VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation., Anti-TNF-alpha antibody (infliximab) therapy for Crohn's disease supports the recovery of eNOS and VEGFR2 protein expression in endothelial cells., These findings reveal a novel role of DCN as an antagonistic ligand for VEGFR-2., A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt., Immunohistochemical analysis of early-stage breast cancer, RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways., autocrine and/or paracrine VEGF/VEGFR signaling plays a functional role in some VEGF-sensitive cancers, including malignant astrocytoma and fi brosarcoma, These data indicate that angiogenesis induced by Flk-1+ hBMSCs promotes endogenous neurogenesis, which may cause functional recovery after cerebral ischemia., Studies indicate that 48 biomarkers have been identified for ccRCC patients, only CD44, CA9, p53, Ki67 and PCNA have shown prognostic value, and IMP-3 and VEGF-R2 are predictors of survival of pRCC patients., Single nucleotide polymorphisms and haplotype of kinase insert domain-containing receptor KDR play crucial roles in the increased risk of ischemic stroke in the Korean population., Findings may have important implications for understanding the molecular basis of genetic associations between KDR variation and clinical phenotypes related to VEGFR-2 function., galectin-3 contributes to the plasma membrane retention and proangiogenic function of VEGF-R2., majority of the thermodynamically destabilizing missense mutations were located in exon 1 in the core of pVHL, whereas protein surface mutations in exon 3 affected the interaction domains of elongin B and C, Data show that normal thyroid follicular cells express VEGFRs 1, 2, and 3., Data suggest that arterial dysfunction found in patients with beta-thalassaemia major before and after HSCT may be related to impaired proliferation of CD133(+)VEGFR2(+) and CD34(+)VEGFR2(+) cells., VEGF covalently bound through a modified heparin molecule elicits an extended response of phosphorylated VEGFR-2 in HUVEC cells, and the covalent linkage reduces internalization of the growth factor during receptor endocytosis, plasma concentration significantly lower in patients with mild preeclampsia who subsequently developed severe preeclampsia than in those who remained stable until term, Data confirm the selectivity of VEGF(121)/rGel for VEGFR-2-overexpressing endothelial cells and represent the first analysis of genes governing intoxication of mammalian endothelial cells by a gelonin-based targeted therapeutic agent., Data suggest that GEP100-Arf6-AMAP1-cortactin pathway, activated by VEGFR2, appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets., arachidonic acid significantly decreased methylation of the promoters of both KDR and Notch4 genes in Human umbilical vein endothelial cells., Plasma sVEGFR-2 concentrations in late onset preeclampsia are significantly lower than that of uncomplicated pregnant women only in patients without evidence of an underperfused placenta., In MCCRCC patients treated with sunitinib, VEGF SNP -634 is associated with hypertension and a combination of VEGF SNP 936 and VEGFR2 SNP 889 genotypes is associated with overall survival., MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1., We found binding programmed cell death 6 to vascular endothelial growth factor receptor 2, a key player in the PI3K/mTOR/P70S6K signaling pathway, KDR protein was presented in the cell plasma membrane of human internal tissues., PI3 kinase-alpha/gamma-mediated signaling downstream of VEGFR2 activation regulated Akt-dependent survival signals, but it was not required to activate endothelial nitric oxide synthase or to elicit NO production in glomerular endothelial cells., a new mechanism by which VEGFR2 activates its own promoter that could be involved in amplifying the angiogenic response, In univariate analysis high pVEGFR2/KDR receptor expression was significantly related with poor prognosis, vascular phenotype with regard to VEGFR2 expression and TGF-beta signaling in endothelial cells varies with malignancy in human glioma., role for endothelial ARNO in VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, resulting in the activation of the Akt pathway, vessel permeability, and ultimately endothelial proliferation, All groups of mice that were treated with anti-hVEGFR2 antibody showed markedly reduced tumor growth., VEGF-A plays a role in the occurrence of OHSS, and the amount of biologically available VEGF-A is modulated by sVEGF-R1, R2 and R3, VEGFR2 is critically involved in adhesion molecule induction and monocytic cell recruitment to endothelium in response to non-uniform shear stress and TNF-alpha., MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth, itraconazole interferes with VEGFR2 trafficking, glycosylation, and signaling activity, Data suggest that decreased VEGFR-2 expression in the podocyte processes of children with idiopathic nephrotic syndrome might be regarded as a potent factor of unfavorable prognosis., Data demonstrates for the first time that VEGFR-2 signaling is activated and promotes survival of keratinocytes under moderate dose of UVB irradiation., KDR attenuated CoCl(2)-induced cell injury in HEK293 cells., a physiological function of PrxII as the residential antioxidant safeguard specific to the redox-sensitive VEGFR2, The associations of functional polymorphisms in the VEGFA and VEGFR2 with survival were analyzed in patients with diffuse large B cell lymphoma, Mutations in the activation loop and juxtamembrane domains of VEGFR-2 is not asssociated with chronic myelomonocytic leukemia., Venous smooth muscle cells showed a significant increase in VEGFR-2 expression under hypoxia compared with arterial smooth muscle cells., analysis of of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase, study shows that FISH positivity for VEGFR2 and KIT occurs in approximately 30percent of Triple-negative breast cancer (TNBC) and 18percent of non-TNBCs. increased VEGFR2 and KIT copy numbers were corr;lated, probably reflecting co-amplification; no correlation between protein levels and copy number for either VEGFR2 or KIT was observed, VEGF-A stimulation of lymphatic endothelial cells leads to the phosphorylation of VEGFR2 (Tyr 951, 1054, 1059, 1175, and 1214) which subsequently triggers PKC dependent phosphorylation of ERK1/2 and PI3-K dependent phosphorylation of Akt., our findings suggest Single nucleotide polymorphisms in the KDR gene modulate colorectal cancer recurrence, especially in those receiving chemotherapy., In the early stage of angiogenesis, VEGF-R2 leads to expression of VEGF, and HIF-1 mediates increased VEGF expression in response to hypoxia in swollen tissues or during the expansion of periodontal tissues., IDH1 mutation may correlate with the benefit from VEGF(R)- versus EGFR-targeted therapy at the time of recurrence in glioma patients, Immunostaining for VEGF and its R1 and R2 receptors was present both in tumor cells and mast cells., This study revealed that VEGFR1 and VEGFR2 correlate with tumor localization, tumoral area (front vs. center of the tumor), histological differentiation degree, and lymph node involvement, while only VEGFR1 correlated with stage., Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization., Data show the potential of Nanobodies for the blockade of VEGFR2 signaling and provide a basis for the development of novel cancer therapeutics., VEGFR inhibition increases iodide uptake and decreases PA production through regulation of p42/44 MAPK phosphorylation., molecular dynamics simulations were used to gain insight into the conformational switching activity of the KDR domain and to identify intermediate conformations between the two limiting active and inactive conformations, The concentrations of VEGF and VEGFR2 differed more significantly in primary and recurrent forms of arteriovenous angiodysplasias (as compared to venous angiodysplasias)., Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility., A dietary pattern of MRND (meat-rice and noodles diet) and VEGFR2 gene polymorphisms were both associated with increased health risks of lifestyle-related chronic diseases particularly blood glucose and lipid levels in Chinese Malaysian adults., This study shows that VEGFR2 is involved in the delayed phase of endothelial cell barrier dysfunction caused by high oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine concentrations., VEGFR2 is a promising marker for malignant vascular tumors and malignant epithelioid mesothelioma., c-ABL function is to establish a correct and tightly controlled response of endothelial cells to VEGF-A during the angiogenic process., Paternal and neonatal carriage of the Kinase insert domain receptor KDR-604T/C polymorphism is associated with the risk of preeclampsia and small-for-gestational-age infants, KDR mRNA was reduced in placentae from late pre-term births, from pre-eclamptic pregnancies, and pregnancies complicated by gestational hypertension., VEGFR2 is preferentially expressed on the cell surface of the CD133(+) glioma stem-like cells, whose viability, self-renewal, and tumorigenicity rely, at least in part, on signaling through the VEGF-VEGFR2-Neuropilin-1 axis., Vascular endothelial growth factor receptor 2 gene polymorphisms is associated with tumor recurrence in non-small-cell lung cancer., Single nucleotide polymorphisms in VEGFR2 gene is associated with lymphedema after breast cancer., Hantaan virus infection upregulated the expression of beta3 and VEGFR2., These findings identify a potent antimigratory function of HO-1 in VSMCs, a mechanism that involves VEGFA and VEGFR2 upregulation, followed by assembly of inactive VEGFR2/PDGFRbeta complexes that attenuates effective PDGFRbeta signaling., Report VEGFR2 expression in embryonic sympathol-adrenal tissues and differentiated neuroblastomas., genetic association studies in Chinese Malaysian and Japanese adults, results suggest that the kinase insert domain receptor -604C allele may increase the risk of premature ovarian failure development in Korean women, KDR single nucleotide polymorphisms may serve as genetic markers for the increased risk of silent brain infarction among the younger (<65 years) or male only Korean subpopulations., slightly up-regulated in fibroblast-like stromal cells in revision total hip replacement compared to osteoarthritis, Changes in the proportion of circulating VEGFR2- and pAkt- positive cells may be a potential pharmacodynamic marker of the efficacy of antiangiogenic agents, and could prove valuable in determining drug dosage and administration schedule, Expression of VEGFR2 in HL-60 cells decreased after treatment with berberine., We studied the expression of VEGF protein, VEGF-mRNA, VEGF receptor (VEGFR)-1 mRNA, VEGFR-2 mRNA in patients with recurring meningiomas, results demonstrate that the proteolytic enzyme MMP-9 promotes resistant epithelial breast cancer cells migration and tubular network formation through VEGFR-2/ VEGFR-3 activation, Advanced glycation end product Nepsilon-carboxymethyllysine induces endothelial cell injuryinvolving SHP-1-regulated VEGFR-2 dephosphorylation., association with ovarian hyperstimulation syndrome not found for VEGFR2 -604 t>c (rs2071559), VEGFR2 +1719 a>t (rs1870377), c-Jun N-terminal kinase/stress-activated protein kinase regulates VEGFA-induced VEGFR2 sustained phosphorylation, which plays important roles in VEGFA-induced angiogenesis in human umbilical vein endothelial cells., Data demonstrate a central role of Flk-1 in the formation of VM in glioblastoma., The VEGFR-2 is expressed on primary human hair follicle DP cells and VEGF induces proliferation of DP cells through VEGFR-2/ERK pathway, but not p38, JNK or AKT signaling., VEGF expression was significantly associated with VEGFR-1 and VEGFR-2 in primary breast carcinomas, higher expression of which selects a prognostically unfavourable patient group., Characterise KDR-positive endothelial-like progenitor cells., Data suggest lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of MMP2 (matrix metallopeptidase 2) and uPA (urokinase-type plasminogen activator) via VEGFR2-mediated signaling., We defined a molecular mechanism by which FAS1 domain protein blocks the association between alpha 5 beta 3 integrin and VEGFR-2, Data show that beta-TRCP knockdown causes accumulation of VEGFR2, resulting in increased activity of signaling pathways downstream of VEGFR2., Data suggest that CD146 interacts with VEGFR-2 in vascular endothelium and promotes angiogenesis; studies include identifying the basis of CD146 binding to VEGFR-2., Pharmacological activation of endothelial LXRs reduces angiogenesis by restraining cholesterol-dependent vascular endothelial growth factor receptor-2 compartmentation and signaling., VEGF/flk-1 participate in the growth of nasal inverted papillomas. Enhanced VEGF/flk-1 in the epithelium may be indicative of malignant transformation., This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells., Elevated expression of cyclin I and VEGFR-2 is likely to provide a proliferative advantage to the EOC cells, and that cyclin I may be linked with angiogenesis in EOC. Higher expression of VEGFR-2 is associated with more advanced disease., demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex, The findings indicate that VEGFR-1 subunits modulate VEGF activity predominantly by forming heterodimer receptors with VEGFR-2 subunits and such heterodimers regulate endothelial cell homeostasis., Data show that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in umbilical venous endothelial cells inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling., Beta(2)-GPI suppresses VEGF-induced phosphorylation of VEGF receptor 2., Formation of pial collaterals occurs during a narrow developmental window via a sprouting angiogenesis-like mechanism requiring VEGF stimulation of FLK1., The functions are mediated by endothelial S1PR1, which in turn regulates the interplay between VE-cadherin and VEGFR2., Alternative polyadenylation of exon 30 or intron 13 leads to the production of mbKDR or sKDR, respectively, yet the regulatory mechanisms are unknown, Higher levels of VEGFR2 and frequency of AG (rs1531289) genotype are linked to the pathogenesis of age-related macular degeneration., Except for VEGFR-2, extensive staining was observed for all VEGF ligands and receptors in the prostate cancer specimens., VEGFR-1, VEGFR-2 and VEGFR-3 are expressed in both fetal and adult bone. The gene expression levels were significantly higher in fetal samples especially in mandibles. In addition, higher levels of VEGFR-3 in orofacial district were confirmed., Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways, The KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024)., Although structural data suggest that both VEGFR2 SNPs may contribute to systemic lupus erythematosus pathogenesis by impairing VEGF signalling, none of the SNPs analysed was associated with increased susceptibility to SLE., Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2., VEGFR2, PDGFRalpha and PDGFRbeta mutations were evaluated by sequencing their tyrosine kinase domains., By augmenting VEGFR2 expression in the placental amnion, PBEF primes the tissue for a VEGF-mediated increase in permeability., MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB, An association between the KDR -604T-->C polymorphism and recurrent spontaneous abortion was found in Korean women., KDR polymorphism is associated with colorectal cancer., [review] Binding ability of in vitro cultured CD34+/KDR+ cells capable of homing to sites of neovascularization suggests that this pair of antigens serves to characterize circulating endothelial progenitor cells., Data suggest that signaling via VEGFA-VEGFR1/FLT1 and VEGFA-VEGFR2/FLK1 plays central roles in regulation of angiogenesis and lymphangiogenesis; VEGFA-VEGFR/FLT1 and VEGFA-VEGFR2/FLK1 signaling is crucial for tumour angiogenesis. [REVIEW], Ang-2, Tie-2 and VEGFR-2 are involved in the development, invasion, metastasis, and prognosis of colorectal cancer, and play important roles in angiogenesis., Results suggest that FOXP3(+)VEGFR2(+) may be a better predictive Treg cells marker than FOXP3(+) alone for recurrence and survival in patients with colorectal cancer., VEGF and VEGFR-2 was detected in macrophages and endothelia of abnormal vessels in eyes with Coats' disease., VEGF, VEGF-R1 and VEGF-R2 are over-expressed in tumour epithelial cells in oesophagogastric cancer., Downregulation of VEGF-A and VEGFR-2 expression mediated by Jiedu Xiaozheng Yin, a Chinese herbal formula, inhibits tumor angiogenesis., miR-17-3p is a negative regulator of the angiogenic phenotype of endothelial cells through its ability to modulate the expression of Flk-1, which is implicated in the pleiotropic effects of miR-17-92 in angiogenesis., This is the first report demonstrating that Myo1c is an important mediator of VEGF-induced VEGFR2 delivery to the cell surface and plays a role in angiogenic signaling., angiotensin through AT1-R modulates KDR expression and have influence on local VEGF level., VEGFR-2 and PAR-1 polymorphisms predicted longer disease-free survival and overall survival in pancreatic carcinoma. CXCR-2 polymorphism was a negative predictor for disease-free survival., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., VEGFR2 internalization may be a generic requirement for pro-angiogenic growth factors to activate endothelial ERK1/2 signaling, Brucine potently suppresses angiogenesis by targeting VEGFR2 activation and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies., NCTD specifically abrogated the phosphorylation/activation of vascular endothelial growth factor receptor-2., A significant correlation exists between CTP measures and EGFR overexpression in head and neck squamous cell carcinomas, suggesting an association between certain imaging findings and molecular biomarkers., Endorepellin binds through its proximal LG1/2 domains to VEGFR2 and inhibit VEGFA-dependent endothelial migration., The results suggest that VEGF may play a key role through VEGFR-2 in the pathogenesis of pterygium., 3 days after hindlimb ischemia, VEGFR2 surface levels were decreased by 80% compared with endothelial cells from the nonischemic limb., altered expression of esVEGFR-2 is correlated with progression of esophageal squamous cell carcinoma, Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR., TXNIP is essential for VEGFR2 internalization in Rab5 positive endosomes, which is required for endothelial cell growth and angiogenesis., Our data suggest that soluble forms VEGFR2CSF may be more potent than VEGFR1CSF in predicting the outcome of leukemia patients, Data indicate statistically significant correlations were observed between the number of circulating epithelial tumor cell (CETC) and IGF-IR and VEGFR-2 expression., COSMC is a novel regulator for VEGFR2 signaling in endothelial cells and dysregulation of COSMC expression may contribute to the pathogenesis of hemangioma, Tumor cells proliferation reduces in a VEGF/VEGFR2-dependent manner as long as the nutrient supply remains decreased., analysis of expression of VEGF and its receptors VEGFR1 and VEGFR2 in primary and recurrent WHO grade III meningiomas, patients with TT polymorphism of rs833061, CC polymorphism of rs699947, CC polymorphism of rs2010963 and CG polymorphism of rs6877011 seem to have a worse PFS and OS when receiving first-line sunitinib., Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma., VEGF promotes glioblastoma multiforme cells proliferation through VEGFR2 but not VEGFR1., Our study demonstrates VEGFR-2 as an essential molecule to sustain the "stemness" of GSLCs, their capacity to initiate tumor vasculature, and direct initiation of tumor., our findings indicate the therapeutic potential of targeting both c-Met and VEGFRs simultaneously with a single small-molecule inhibitor for the treatment of human cancers, None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST., Mineralocorticoid receptor activation attenuates the expression of the VEGF receptor 2/KDR, possibly dampening the activation of a VEGFA/KDR dependent signaling pathway important for the survival of tumor cells under hypoxic conditions., Data indicate that the VEGFR-2 inhibitory activities in most of the designed molecules were predicted to be in the 0.01-0.1 muM range., These studies reveal mechanical stretch as a potent agonist for endothelial exocytosis, which is modulated by VEGFR2 signaling., The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients., Primary cutaneous large B-cell lymphomas were characterized by significantly higher intratumoral expression levels of VEGF and its receptors in comparison with the indolent lymphoma subtypes., The results suggested that the 1192C/T polymorphisms on the VEGFR-2 gene might affect the risk of developing endometriosis in Northern Chinese women of Han ethnicity., VEGFR2 receptor is capable of synthesising dinucleoside polyphosphates., decursin may be a potent anti-angiogenic and anti-proliferative agent targeting the VEGFR-2 signaling pathway, which significantly inhibits diabetic retinal neovascularization., the results demonstrate that NRP-1 is involved in melanoma progression through VEGFR-2-dependent and -independent mechanisms and suggest NRP-1 as a target for the treatment of the metastatic disease., Diminishing expression of endogenous microRNA-15b increases VEGFR-2 expression in HUVECs., Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways, Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., These results document a physiological role of AR in sex-independent angiogenic potency and provide evidence of novel cross-talk between the androgen/AR signaling and VEGF/kinase insert domain protein receptor signaling pathways., The KDR is a conserved marker for endoderm-derived hepatic progenitors and a functional receptor instructing early liver development., VEGFR2 expression was significantly higher in muscle invasive bladder cancer than that non-muscle invasive bladder cancer which suggests VEGFR2 expression increases with tumor invasion; results suggest that alterations in expression of VEGF and VEGF receptors are associated with disease stage and recurrence, Lactate engaged the PI3K/Akt pathway via ligand-mediated activation of the three receptor tyrosine kinases Axl, Tie2, and VEGF receptor 2., Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2 in colon cancer., Neither Lin-positive transgene nor Lin-negative/VEGF-R2-positive cells form tube-like structures when cells are seeded on Matrigel(R) and observed for up to 1 week, whereas human vascular endothelial cells (HUVEC) form tube-like structures after 6 hours., VEGF-A, VEGFR-1 and VEGFR-2 were statistically correlated with ramifications of blood vessels. No correlation with patient outcome was observed., data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function., Single nucleotide polymorphisms in KDR gene is associated with colorectal cancer risk., addition of both galectins induced a decrease in the VEGFR1 and VEGFR2 endocytic pools, with a significantly enhanced effect on the VEGFR1 endocytic pool, VEGF and VEGF receptors 1 and 2 have roles in malignant colonic epithelial cell growth through an autocrine mechanism, VEGFR2 rs12505758 variants correlated with progression-free survival., CD45(-)/CXCR4(+)/FLK-1(+) cells may provide a diagnostic tool to follow cardiac regenerative capacity and potentially serve as a prognostic marker in acute myocardial infarction., Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering age related macular degeneration in a Spanish population., Soluble VEGFR-2 may be involved in the pathogenesis of macular edema associated with branch retinal vein occlusion., We have identified the baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios as potential biomarkers of response in ABCP treated metronomically with Cy+Cel. This finding warrants its confirmation in a higher number of patients., Data indicate differential patterns of gene amplification and expression of receptor tyrosine kinases PDGFRA, KIT, and VEGFR2 at the 4q12 locus to be associated with specific phenotypes., Neoplastic and non-neoplastic Barrett's epithelial cells have autocrine VEGF signaling. In neoplastic Barrett's cells, VEGF activation of VEGFR2 initiates a PLCG1-protein kinase C-ERK pathway that promotes proliferation., Single nucleotide polymorphisms in KDR are associated with treatment failure in sunitinib treated gastric and biliary tract cancer patients., The possibility to express an angiogenesis regulator as sVEGFR2, in a hypoxia-conditioned manner, significantly opens new strategies for tumor vessel-controlled normalization and the design of adjuvants for combined cancer therapies., Probe F2 was capable of enriching all members of the FGF receptor family as well as other kinases involved in cancer such as KDR, FLT4 and RET from lysates of cancer cells or human placenta tissue., sFlt-1, which is known to be increased in hypoxic conditions and pre-eclampsia, directly attenuates VEGFR-2 expression and signaling., VEGF165 / VEGFR-2 have roles beyond angiogenesis in hair follicle regulation, methylation of Lys(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases., decreased expression of VEGFR1 in decidua and weaker VEGF and VEGFR2 expression in placental villi and decidua may be associated with early pregnancy loss., Identification of a G-rich sequence within the proximal promoter region of vegfr-2 that is able to form an antiparallel G-quadruplex structure., The expression of VEGF and its receptors (VEGFR-1, VEGFR-2 and VEGFR-3) was ascertained to be increased in the placental terminal and stem villi, mostly in type 1 diabetes., Polymorphisms in the VEGFR2/KDR gene significantly influence visual outcome in patients receiving ranibizumab treatment for neovascular AMD., Hyperglycaemia in Type 1 diabetes mellitus impairs VEGFR2 protein expression in ischaemic hind limbs, High VEGFR2 expression is associated with worse treatment response in hepatocellular carcinoma., There is evidence of increased placental angiogenesis in late-onset pre-eclampsia and early-onset pre-eclampsia that is associated with differential activation of VEGFR2., Low gene expression contributes to dysfunctional mobilization of bone marrow cells from VEGF-R2 transgenic mice., Polymorphisms of VEGF A seem to influence the different response to antiangiogenic treatment in patients with age-related macular degeneration in our population., associations and gene-diet interactions involving vascular endothelial growth factor receptor-2 gene polymorphisms and fruit diet on uric acid provide new information on gout and hyperuricaemia risks in Malays, ERK3 regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3/SP-1-mediated VEGFR2 expression., post-translational modification by acetylation is a critical mechanism that directly affects VEGFR2 function., p53, human telomerase reverse transcriptase, Wilms tumor-1, and vascular endothelial growth factor receptor 2, could induce specific cytotoxic T lymphocytes that showed cytotoxicity against pancreatic cancer cell lines., Activation of FLK1-neuropilin-1 signaling in the lung leads to inhibition of epithelial cell apoptosis., no pharmacogenetic associations exist between the studied VEGFA and VEGFR2 SNPs and response to anti-VEGF therapy., VEGF-A, VEGFR-1, and VEGFR-2 were shown to be up-regulated in malignant Pheochromocytoma, suggesting that these molecules might be considered as therapeutic targets for unresectable or metastatic tumors., An excess of VEGFR2 -604TT genotype was seen in multiple myeloma patients with stage II or III tumors when compared with those with stage I tumors., In primary ovarian cancer tissue, VEGFR2 expression, detected with an frequency of 18%, was mostly located in the vascular wall and across the stroma., in B1647 leukemia cells, VEGFR-2 is present in caveolae through association with Cav-1, demonstrating that caveolae/lipid rafts act as platforms for negative modulation of VEGF redox signal transduction cascades, The expressions of VEGF-A, VEGFR2 and VEGFR3 were studied in by immunohistochemistry in 76 endometrial carcinoma specimens. VEGFR2 and VEGFR3 receptor expression were also studied by qRT-PCR in 17 tumors in comparison to normal endometrium., Cerebrospinal fluid from amyotrophic lateral sclerosis patients caused significant down-regulation of VEGFR2., genetic association studies in population in Washington DC, The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays occurrence of vascular complications., Results show that thioridazine regulates endothelial cell function and subsequent angiogenesis by inhibiting VEGFR-2/PI3K/mTOR signal transduction., Data show that doxazosin inhibited the phosphorylation of VEGF receptor-2 (VEGFR-2) Akt and mammalian target of rapamycin (mTOR), and hypoxia-inducible factor 1 (HIF-1alpha) expression., PTP1b is a key regulator of endothelial VEGFR2 signaling and plays an important role in regulation of the extent of vascular tree formation., the proteins c-KIT, VEGFR2 and PDGFRalpha, encoded by genes at 4q12, are associated to the St Gallen breast cancer subgroup TNBC. No correlation was seen between high protein expression, increased gene copy number and BCM in the TNBC group., Suggest dioscin as a potential anticancer drug, which efficiently inhibits angiogenesis induced by endothelial cell VEGFR2 signaling pathway as well as AKT/MAPK pathways., KDR rs2071559 GA genotype was significantly over-represented in the female controls, the carboxy terminal domain inhibits VEGFR-2 activity in the absence of ligand, Single-nucleotide polymorphisms of KDR are associated with response to therapy in hepatocellular carcinoma., KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis., The present study demonstrates that the CC genotype of the KDR -604T>C polymorphism (rs2071559) is a possible risk factor for MI in Caucasians with T2DM., NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions., KDR gene knockdown induces apoptosis in human MCF-7 breast cancer cells ., Our results suggest that SNPs in KDR gene can predict clinical outcome in advanced HCC patients receiving first-line sorafenib., VEGF and VEGFR2 expression were increased after low level laser therapy in human adipocyte-derived mesenchymal stem cells., GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling, high levels of miRNA-185 in RCC are associated with high VEGFR-2 mRNA and protein levels and a higher density of microvessels., Our results indicate that reduced expression of the nuclear long noncoding RNA NEAT1 may play a role in the myeloid differentiation of APL cells., KDR gene plays a certain role in promotion of human prostate cancer PC-3 cells' proliferation, These results demonstrate the fully human VEGFR2 monoclonal antibody BC001 can work as an effective inhibitor of tumor angiogenesis and tumor growth both in vitro and in vivo, there is HER2 and EGFR, but not VEGFR expression in micropapillary urothelial carcinoma with invasive urothelial carcinoma, These data demonstrate that ethanol activates Flk-1 and Flt-1 receptors in vascular endothelial cells and promotes angiogenic activity via an Flk-1/notch pathway., The results show that VEGFR1-VEGFR2 levels are more closely coupled than VEGFR1-VEGFR3 or VEGFR2-VEGFR3 in HUVEC and MEC., These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis, VEGFR family members are expressed in leiomyosarcomas in vivo and in vitro. Upon receptor stimulation, PTK787 is able to inhibit subsequent phosphorylation events and influences cell survival but not metabolic activity and migration, Our results demonstrated that a significantly higher amount of sunitinib could be delivered to the U87MG tumor by targeting VEGFR when compared with the non-targeted counterparts., VEGFR2 is phosphorylated in a process involving carbon monoxide inhibition of sprouting angiogenesis, early stage colorectal adenocarcinomas with highly activated (phosphorylated) VEGFR-2 expression may indicate the significance of neoangiogenesis of the tumors., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2., N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain., the best characterized of these signaling pathways, that involving the vascular endothelial growth factor (VEGF) family members VEGF-C and VEGF-D, together with their receptors VEGFR2 and VEGFR3., Rs34231037 is associated with serum VEGFR2 response to pazopanib., results of the current study suggest that expression of MMP9 and VEGFR2 is associated with epithelial dysplasia grading., Further conclusion showed that Prdx2 regulates VM formation by targeting VEGFR2 activation, which now represents as a therapeutic target for RC., There was no significant association between VEGFR2 polymorphisms and susceptibility to chronic lymphocytic leukemia., AKT3, PI3KCA, and VEGFR2 silencing reduces the invasiveness of glioblastoma multiforme T98G cells., The pharmacogenetic statistical interaction between VEGFR-2 rs11133360 and IL-8 rs4073 genotypes may identify a population of patients with a better outcome., results demonstrate that Mixl1 and Flk1 play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 cells., cytoplasmic expression of VEGF, VEGFR2, PDGF-B, and PDGFR-beta in RCC tumour cells is different in various pathologic stage and cell type. Notably, VEGF and PDGF-B expression are higher in papillary than in clear cell renal cell carcinoma., This review presents an update on the potential role of VEGF and VEGF receptor-2 SNPs as prognostic and/or predictive markers in patients with breast cancer., Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma., Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv., The gene-gene interactions identified in the survival tree analysis support the importance of VEGFR2 rs2071559 and KISS1 rs71745629 in modulating these outcomes., Studies indicate that patients most likely to benefit from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor (anti-VEGF/anti-VEGFR) therapy., a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, There were no significant correlations between VEGF, sVEGF-R1, sVEGF-R2, and platelet counts in chronic urticaria and the healthy subjects, Data show that prohaptoglobin promotes angiogenesis via vascular endothelial growth factor (VEGF) and VEGF receptor2 signalling., Ramucirumab, a human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2, was well tolerated in patients with advanced solid tumors., Gremlin/VEGFR2 axis participates in renal inflammation and could be a novel target for kidney disease., CD147 is a novel coreceptor of VEGFR-2 with a role in mediating its activation by VEGF, Data suggest that plasma levels of VEGFR2 are down-regulated in patients with type 2 diabetes mellitus as compared to control subjects., Significant and consistent inhibition of the VEGF pathway (using VEGFR2 as the readout) was observed in granulation tissue biopsies from patients treated with bevacizumab and everolimus., findings show that VEGF-R overexpression occurs frequently in OSCC and could have clinical implications, Our findings indicate that activation of VEGFR1 and VEGFR2 in epithelial and inflammatory cells appears to be an early event in lip carcinogenesis., Results support a CTLA4-Ig/CD86 interaction on gammaIFN and IL-17 activated endothelial cells that modulates the expression of VEGFR-2 and ICAM1., Data indicate that foretinib suppresses angiogenesis and lymphangiogenesis by blocking vascular endothelial growth factor receptors VEGFR-2/3 and TIE-2 receptor signaling., PEDF binds VEGFR-1 and VEGFR-2 in vascular endothelial cells., The VEGFR-2 activating pathway is closely involved in tumor cell-associated, vessel-mediated and immuno-inflammatory processes in colon carcinoma, study found VEGFR2 correlates with the clinical severity of dengue and muscle dysfunction, TRPC1 functions as a major regulator of S1P3 and VEGFR2 expression., VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer, CA down-regulates the VEGFR2/Src/FAK/cdc42 axis., Heparin influences VEGF receptor-1, VEGF receptor-2, and neuropilin-1 through distinct mechanisms and regulates VEGF-induced signaling., data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations., We found that expression of Gab1, VEGFR-2, and MMP-9 was highly and positively correlated with each other and with lymph node metastasis and TNM stage in intrahepatic cholangiocarcinoma tissues, Thus, (131)I-anti-VEGFR2 cFab has the potential to be used for molecularly targeted treatment of hepatocellular carcinoma overexpressing VEGFR2., Our findings demonstrate for the first time that CHIP may be involved in RCC angiogenesis through regulating VEGF secretion and expression of VEGFR2., The CATT and IVAN data do not support a pharmacogenetic association between the 2 VEGFR2 SNPs, rs4576072 and rs6828477, and change in VA in response to anti-VEGF therapy in patients with neovascular AMD., The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2., mutant p53 impacts transcription of VEGFR2 as well as myriad other genes by promoter remodeling through interaction with and likely regulation of the SWI/SNF chromatin remodeling complex, VEGF and VEGFR2 and angiogenic activity are present in dental follicles and dentigerous cysts and may contribute to local bone resorption for tooth eruption or the development and progression of dentigerous cysts, MET suppresses VEGFR2 protein by inducing its endoplasmic-reticulum-associated degradation (ERAD), via intracrine VEGF action., Sorafenib controls the growth of endometriotic lesions in vitro and in vivo by inhibiting MAPK/VEGFR signaling., inhibitory effect of RSV on the HIF-1alpha/VEGF/VEGFR2 signaling axis is mediated, at least in part, through SIRT1, High VEGF plus VEGFR expression and AKT phosphorylation are highest in leukocytes of remission patients, suggesting VEGF signaling as a cause of reduced apoptosis susceptibility upon treatments., The properties of VEGFR2 and c-telopeptide collagen observed in this study inform the design of future combination antiangiogenic therapy trials., Patients with clear cell renal cell carcinoma were associated with high levels of VEGFR-2 protein expression., Suggest curcumin as a inhibitor of VEGF-VEGFR2 signaling pathway in endothelial cells to prevent tumor growth., High VEGFR2 expression is associated with Gastric Adenocarcinoma., This large study highlights the prognostic importance of VEGF-A and VEGFR-2 stromal expression in prostate cancer., High expression of VEGFR2 (KDR) is significantly associated with decreased patients' survival, Data suggest that targeting endothelial growth factor receptor 2 (VEGFR-2/KDR) with TTAC-0001 could be a promising approach for cancer treatment., The genetic statistical interaction between VEGFR-2 (rs2071559, rs11133360) and P2X7R (rs3751143, rs208294) genotypes may identify a population of prostate cancer patients with a better prognosis., miR-497 inhibits tumor angiogenesis and growth via targeting VEGFR2, indicating miR-497 can be explored as a potential drug candidate for cancer therapy., Findings suggest that VEGF(R)-inhibition may improve the efficacy of intraperitoneal chemotherapy (IPC), particularly for patients for whom a complete cytoreduction might not be feasible., This study provides initial evidence that (64)Cu-NOTA-RamAb can function as a PET imaging agent for visualizing VEGFR-2 expression in vivo, uPAR-VEGFR2 interaction is crucial for VEGF signaling in endothelial cells, KDR siRNA can significantly silence KDR gene and protein expression in A549 cells, inhibit the proliferation of A549 cells, and enhance their sensitivity to docetaxel, IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients., TLR4 knockdown inhibited VEGF signaling through VEGF receptor 2 (VEGFR2)., Negative for VEGF/VEGFR2., Report KDR genetic alterations in angiosarcomas., Hydrogen sulfide promotes angiogenesis by downregulating miR-640 and increasing the levels of HIF1A through the VEGFR2-mTOR pathway., Meta-analysis. Our finding indicates that VEGFR polymorphism +1192C>T and +1719A>T may be associated with the risk of stroke, but not -604T>C.,
OMIM_DISEASE Hemangioma, capillary infantile, somatic, Hemangioma, capillary infantile, susceptibility to,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains., subunit:Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat.,