Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
0
DAVID Functional Annotation Table
Gene Report
Help and Manual

Right-click and select 'Save Target As' to download results Download File
fibronectin 1(FN1) fibronectin 1(FN1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q34,
ENSEMBL_GENE_ID ENSG00000115414,
GENERIF_SUMMARY Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium, We show a novel alternative pathway of apoptosis that is regulated by the alternatively spliced V region and high-affinity heparin-binding domain of fibronectin, Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride, Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading., Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus; multivariate analysis showed that plasma fibronectin levels were not an independent predictor of LV thrombus formation., Low density lipoprotein receptor-related protein (LRP) functions as a catabolic receptor for Fn, Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11)., differential role of u-PA and t-PA as inducers of fibronectin mRNA, investigation of the role of direct contact with stroma and the ECM protein fibronectin in the preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors, Adhesion of hairy cells to fibronectin inhibits interferon-alpha-induced apoptosis., fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility, Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., proximal tubular cell fibronectin production induced by oleate-complexed recombinant human serum albumin was mediated via protein kinase C activation, These data indicate that fibronectin polymerization is a critical regulator of extracellular matrix organization and stability., familial combined hyperlipidemia plasma stimulated secretion of several distinct hepatic proteins, among which fibronectin was identified, FN may be partly involved in the increase in SPARC (secreted protein, acidic and rich in cysteine) glycoprotein expression by TGF-beta 1 in human periodontal ligament (HPL) cells., REVIEW, Streptococcus pyogenes isolates were able to recruit collagen type IV via surface-bound fibronectin; fibronectin-mediated collagen recruitment represents a novel aggregation, colonization and immune evasion mechanism of S. pyogenes, FN may have a role in the pathogenesis of papillary thyroid carcinoma, all six modules of the gelatin-binding domain contribute to the interaction with gelatin either directly by contacting the ligand or indirectly through module-module interactions, differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the Sturge-Weber syndrome (sws) normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS., Fibronectin secretion by renal fibroblasts was increased upon exposure to high glucose, but with delayed kinetics compared to TGF-beta1-induced fibronectin., Pathogenic bacteria, Staphylococcus aureus and Streptococcus pyogenes, attach to human fibronectin through a tandem beta-zipper, AngRem104 is a novel human gene potentially involved in regulation of fibronectin induced by AngII in human mesangial cells., An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases., an additional marker of malignant potential of thyroid nodular lesions (oncofetal fibronectin), levels of fibronectin in the extracellular matrix are regulated by uPAR and integrin receptors, FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis., Fibronectin plus TNF-alpha stabilizes granulocyte macrophage-colony-stimulating factor (GM-CSF) mRNA, increases GM-CSF secretion, and prolongs in vitro eosinophil survival., Abundant expression of fibronectin is a major feature of leukemic dendritic cells differentiated from patients with acute myeloid leukemia, the aggrecanase activity of ADAMTS4 is inhibited by fibronectin through interaction with their C-terminal domains, crystal structure of the 2F1(3)F1 module pair, human fibronectin binding to streptococcus requires specific recognition of sequential F1 modules, Adding 110-120 kDa fibronectin fragments to normal blood replicated changes in monocyte CD49e, CD62L, CD11b, & CD86 seen in vivo in HIV-1 patients. FNf caused monocytes to release proteinase-3. Monocyte behavior in HIV-1 patients may be affected by FNf., Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., fibronectin concentration significantly elevated in ovarian cancer patients with recurrent disease compared with ovarian cancer patients without recurrence, demonstrate that integrins alpha(5)beta(1) and alpha(v)beta(3) support fibronectin-dependent platelet adhesion and the generation of filopodia but that, in contrast to the integrin alpha(IIb)beta(3), are unable to promote formation of lamellipodia, Site-directed mutagenesis of amino acids coordinating Ca2+ drastically decreased the binding of C-reactive protein to fibronectin (Fn), indicating that the Ca2+ -binding site indeed formed the Fn-binding site., Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, integrin-dependent function of the ninth and tenth FIII domains of human fibronectin depends on interdomain tilt angle, adhesion of uveal melanoma cells to the extracellular matrix proteins fibronectin, type IV collagen and laminin might confer resistance to the chemotherapeutic agent cisplatin, The heparin II domain of fibronectin mediated the incorporation of paxillin into focal adhesions., Fibronectin enhances IL-1 beta-dependent airway smooth muscle cell secretory responses through a beta 1 integrin-dependent mechanism., SGK1 activation has a role in oncofetal fibronectin expression, Fibronectin and ezrin were upregulated in primary laryngeal carcinoma., Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis., FN modulates thyroid cancer cell adhesiveness and, at least in part, mediates vitamin D actions on neoplastic cell growth., The relative amounts of the 60, 90 and 100 kDa FN fragments were 2-3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group, suggesting that seminal plasma FN fragments may contribute to fertilization., FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, Chemical shift differences between the fibronectin glycoforms have revealed an intimate interaction between one N-linked sugar and the polypeptide that is critical for gelatin binding., Over-expression of oncofetal fibronectin is associated with thyroid carcinoma, binding with C terminus of apolipoprotein [a], These results provide evidence for an additional level of control of fibronectin deposition through cell interactions with the local microenvironment., the role of the extra domain A (EDA) and type III connecting segment (IIICS) of fibronectin in fiber assembly, topographical distribution and proteolytic cleavage, Results show fibronectin plays a role in the regulation of hematopoiesis by binding to FLRG and follistatin., platelet fibronectin may have a role in progression of coronary artery disease, The expression of FN protein was higher in cortex cataract than in nuclear cataract., Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, Results indicate that the adhesion mechanism by embryonal fibronectin may be involved in human blastocyst implantation., constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP, review goes over roles of fibronectin in platelet functions with a focus on fibronectin assembly within developing platelet thrombi., Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., IL-1, FN, and FN-derivatives have interrelated roles in determining biomaterial-modulated macrophage function [review], The role of the matricryptic site of the fibronectin terminal repeat III1 in cell proliferation and growth is reported., Review highlights the role of fibronectin as a key orchestrator for the assembly of multiple extracellular matrix proteins., Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP., the FN1 alpha-helix is involved in an Ig5-FN1 interaction that is critical for the correct positioning of Ig5 N-glycans for polysialylation, analysis of L-isoaspartate formation and gain of function in fibronectin, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., Downregulated expression of migration-inducing FN-isoforms in contrast to unchanged FN receptor expression may contribute to the observed alterations of Crohn's disease colonic lamina propria fibroblasts migration., Our results indicate that Src maintains fibronectin matrix at the cell surface through its effect on integrin activity and paxillin phosphorylation., fibronectin does not have an obvious role in development or progression of coronary artery disease, epithelial fibronectin suppression is not only involved with malignancy, but can also occur with benign processes that involve leukocyte migration, local presence of endogenous Tlr4 ligand Fibronectin EDA is not associated with in an unstable plaque phenotype in humans, Interaction of fibronectin carboxy-terminal regions with the fibrin alpha C chain occurs through two types of binding sites, one with high affinity and another one with much lower affinity, both of which play a role during hemostasis and wound healing., Smad 7 transfection reduces the expression of COL1A2 mRNA and the synthesis of type I collagen, but has no effect on fibronectin mRNA expression., ED-B fibronectin expression is closely associated with inflammation in atherosclerosis., The IIICS region of FN is a novel zinc-binding module., Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production, MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the risk of lymphoma development in MCsn., TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., Fibrinogen has a role in controlling human platelet fibronectin internalization and cell-surface retention, study concludes that increased platelet fibronectin may partially contribute to platelet aggregation in patients with coronary artery disease, Expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC., These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., high molecular weight hyaluronan suppresses HBFN-f-activated NF-kappaB in rheumatoid arthritis chondrocytes, Results show that neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2)is co-expressed with migration stimulating factor (MSF or FN1) by keratinocytes and acts as a functional inhibitor of MSF., expression of the alternatively spliced extra-domain A (EDA) of fibronectin in the neovasculature of metastases and primary tumors of human cancer patients was shown, TSG-6 is a high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells, These data provide the first evidence that IL-18 and FN stimulate each other's expression., These results suggest that fibrinogen and fibronectin facilitate the adherence of Paracoccidioides brasiliensis conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system., dominant mutations in FN1 accounted for 40% of cases of Glomerulopathy with fibronectin (FN) deposits in our study group, These results are consistent with the hypothesis that ScpB binds to a motif created by the juxtaposition of multiple Fn molecules., The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin., Filtering bleb scarring is associated with an abundant expression of TGF-beta receptors in activated fibroblasts and the deposition of the fibrogenic ED-A fibronectin splice-variant., MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, KLK7 is able to cleave fibronectin in a time-dependent manner, but not laminin., Increased production of a fibronectin isoform containing the oncofetal domain and its release in the circulation in patients with primary biliary cirrhosis is at least partially responsible for the decrease in bone formation., Results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development., A link between fibronectin expression and epithelial cell growth during development and oncogenesis in the mammary gland., Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., Inflammation-induced modulation of FN-isoform production is involved in the alterations of migratory potential of CLPF isolated from CD mucosa., elevated plasma fibronectin levels are associated with venous thromboembolism (VTE) especially in males, and extend the potential association between biomarkers and risk factors for arterial atherothrombosis and VTE, four crystal structures that together comprise the structures of two complete high-affinity binding repeats for Fn from FnBPA and FnBPB, each in complex with four of the N-terminal modules of Fn, Plasma fibronectin level is increased in patients with severe coronary artery disease, namely, those who have at least one critically stenosed coronary vessel, compared to patients with normal coronary arteries., analysis of fibronectin expression in benign hyperplasia and cancer of the prostate, These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Genotyping for HaeIIIb fibronectin gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in mixed cryoglobulinemic syndrome., a new mechanism of fibroblast activation, which is initiated by interaction of fibronectin with its integrin receptors., MAGE A3 is a functional integrator of diverse signals, including FGFR2 and FN, to modulate cancer progression., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., The simultaneous positivity for thyroid specific factor TTF-1 and onfFN suggest they might represent putative thyroid cancer stem-like cells., analysis of the unfolding of the tenth type-III repeat of human fibronectin, Dynamic mechanical forces could regulate the expression of collagen type I and fibronectin mRNA in periodontal ligament fibroblasts., Mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and FNI(9)., enhanced capacity of fibronectin-adherent HL60 cells to differentiate into macrophages in response to PMA., The 320-kDa and 280-kDa FN forms as well as FN fragments appeared in the pleural effusion and plasma of patients suffering from lung inflammation or cancer in significantly higher relative amounts in both lung cancer groups than in the inflammation., relative amount of EDA-FN in synovial fluid, but not in plasma samples, was significantly lower in the early RA group than in established and late RA. In contrast, its level did not correlate with the CRP concentration, The risk of pneumoconiosis increases in workers with the FN (MspICC or HaeIIIb AA) genotype after exposure to dust. Workers both carrying FN (HaeIIIb AA) and (MspICC) genotypes are more susceptible to pneumoconiosis., role for fibronectin in collagen proteolysis and tissue remodeling, Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30., These results established a novel in vitro dynamic BBB model. We also demonstrated the dependence of leukocyte-endothelial interactions in this model on alpha4 integrins and FN-CS1., Human umbilical vein endothelial cells showed dose-dependent upregulation of fibronectin mRNA exposed to various D-glucose levels., Borrelia burgdorferi virulence factor BBK32 induces the formation of Fn aggregates that are indistinguishable from those formed by anastellin., isoforms of a group B streptococcus-secreted component named Fib displayed differential binding capacities for fibronectin, fibrinogen, and C4BP, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., fibronectin might be a critical molecule produced by T(H)1 cells involved in pathogen eradication., the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., LigB was shown to bind to the N-terminal domain of fibronectin., HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease, FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases., Serum fibronectin concentration in patients with hemorrhagic fever with renal syndrome (HFRS) was increased with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity., higher expression in the fetal skin than in adult skin, AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., Exposure to high glucose and overexpression AR increase the expression of fibronectin., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., the third FN type III repeat (FnIII3) and several fragments containing the repeat promote cell spreading and migration of human dermal fibroblasts (HDFs), whereas the fourth repeat (FnIII4) did not., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., vaginal fetal fibronectin not changed by vaginal ultrasound, Upregulation of fibronectin-1 protects Dicer knockdown HEK293T cells against apoptosis., findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., Increase in urinary fibronectin is associated with bladder tumor., The identification of a fibronectin-binding domain in ameloblastin might permit interesting applications for dental implantology., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., iso-DGR sequences spontaneously converted from NGR are cryptic and do not mediate the interaction of the 70K region of FN with the cell surface during FN assembly, Mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human cancer cells., Data demonstrated that the inclusion of the alternatively spliced angiogenesis-associated ED-B leads to the unmasking of the FNIII 8 B-C loop that is cryptic in FN molecules lacking ED-B., Exposure to ethanol drastically enhances the adhesion of cultured breast cancer cells to fibronectin and increases the expression of focal adhesions., Fibronectin promotes paxillin (tyr118) phosphorylation and invasiveness of AGS cells., An increased expression of fibronectin and tenascin-C mRNA in association to histological damage and in valvular heart disease compared to coronary artery disease could be shown., Fibronectin may modulate the directional migration of corneal epithelial cells, The expression of Col I, Col IV and Fn was closely related to tumor invasion, the regional lymph node metastasis and other pathological features in laryngeal squamous cell carcinoma., our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells., Steric hindrance determines the motogenic activity of MSF and Fn, and that both molecules contain cryptic bioactive fragments., in the presence of laminin and fibronectin, DC maintain a 'more immature' phenotype and express higher levels of key endocytic receptors, and become better endocytic cells, but possess superior ability to induce antigen-specific T cell differentiation., Oncofetal fibronectin transcripts are highly abundant in the peripheral blood of patients with papillary thyroid carcinoma., Elevated urinary fibronectin was identified as an independent factor predicting kidney function deterioration., Data show that metastatic outgrowth is associated with activation of the transforming growth factor-beta signaling pathway and concerted up-regulation of POSTN, FN1, COL-I, and VCAN genes., plays role in bronchial smooth muscle cells migration in the process of airway remodeling, Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac activation by mGBP-2., Data show that occupancy of EPCR by protein C switches signaling specificity so that activation of PAR-1 by thrombin inhibits TNF-alpha-mediated synthesis of IL-6 and IL-8 and down-regulates TGF-beta-mediated expression of collagen type 4 and fibronectin., MSF is a novel marker associated with the M2 stage of macrophage polarization expressed by tumor-conditioned macrophages; MSF may contribute to macrophage-mediated promotion of cancer cell invasion and metastasis., high molecular weight of HA suppressed the FN-f-activated p38 via ICAM-1 and the CD44 in RA chondrocytes, Migration Stimulating Factor, a truncated form of fibronectin that promotes the migration of many cell types, inhibits AKT activity in human fibroblasts, data indicate that higher levels of EDB isoform and FN-f are associated with intervertebral disc degeneration; this shift in alternative splicing may reflect an attempt of tissue repair and remodeling, FN induces MMP-9 in HEp-2 cells mainly by involving integrin receptor alpha5beta1 and involves activation of multiple signaling pathways which independently or in "cross-talk" to each other finally leads to the transactivation of the MMP-9 gene., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, Fetal fibronectin as a predictor of spontaneous preterm birth., Data show that FN III12-14 is a highly promiscuous ligand for GFs and also holds great potential in clinical healing applications., FN upregulates osteoclast activity despite inhibiting osteoclast formation and that these effects involve NO and IL-1beta signaling., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., Tenascin-C contains cryptic sites which can control tissue levels of fibrillar fibronectin either by preventing de novo fibril assembly or reducing levels of deposited fibronectin., In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal., The findings that fibroblast survival is dependent on FN-growth factor binding domains underscore the critical importance of pericellular matrix for cell survival, CTGF cooperates with FN in enhancing the attachment and migration of corneal epithelial cells., Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion., IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin, High FN1 mRNA expression is associated with renal cell cancer., rhFNHN29 and rhFNHC36 inhibit adhesion and invasion of liver cancer cells, syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides, study suggests that FN and tissue transglutaminase (TG2) facilitate the metastatic activity of A431 tumor cells, and this may be partly attributed to TG2 enhancement of the association of FN and beta integrin, These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins., Megakaryocyte adhesion to type I collagen promotes inhibits pro-platelet formation through the release of cFN to the plasma membrane. This regulatory mechanism is dependent on the engagement of FN receptors and on transglutaminase FXIII-A activity., autocrine soluble fibronectin of osteosarcoma MG-63 cells may be involved in cell shape maintaining, Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve., FN upregulation of cGMP-dependent protein kinase (PKG-I) protein content is due to increased mRNA expression via augmented transcriptional activity of the PKG-I promoter region., Cav1.2 calcium channel association with alpha5beta1-integrin depends on adhesion to fibronectin; interactions between alpha5beta1-integrin and fibronectin modulate L-type calcium channel entry., Fetal fibronectin may be used as a primary screening tool for prediction of preterm birth in asymptomatic high-risk women., Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP., Danshensu can protect from oxidative stress through inhibiting the expression of FN and Col-I induced by high glucose., Kindlin-2 regulates podocyte adhesion and fibronectin deposition through interactions with phosphoinositides and integrin b1 and b3., Data show that ITP-79 modulated binding of TG2 to fibronectin., LigB could facilitate leptospirosis transmission by binding fibronectin and fibrinogen, Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression., Increase expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas., This work provides a broad overview of matrix remodeling at the cell-material interface, establishing correlations between surface chemistry, fibronectin adsorption, cell adhesion and signaling, matrix reorganization and degradation., We conclude that TGF-beta1 may both switch on and switch off migration stimulating factor (MSF) expression in a manner critically determined by the nature of the matrix substratum, Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage, Data show that the urinary messenger RNA (mRNA) levels of alpha-smooth muscle actin (alpha-SMA), fibronectin, and matrix metalloproteinase-9 (MMP-9) were significantly higher in the diabetic nephropathy (DN) group, and mRNA levels increased with DN progression., Structural and functional analysis of the tandem beta-zipper interaction of a Streptococcal protein with human fibronectin, Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn., The adhesive properties and thickness of the UspA1 layer at the cell surface varies on addition of either fibronectin or CEACAM1., miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line., the extent of molecular unfolding that contributes to Fn fiber extension, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted AGS cell migration was due to the up-regulation of fibronectin., Fibronectin matrix assembly suppresses dispersal of glioblastoma cells, Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier, Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein, first step in such infections is a bond that forms between fibronectin-binding protein (FnBP) on Staphylococcus aureus and host proteins, such as fibronectin (Fn), that coat the surface of implants in vivo., Data indicate that anti-citrullinated fibronectin peptide antibodies are associated with HLA-DRB1 shared epitope alleles., Allosteric loss of constraining interactions among (1-5)FNI, (10)FNIII, and (12-14)FNIII likely enables assembly of FN into extracellular fibrils., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, these findings provide evidence that extra domain A of fibronectin could play a role in tumor-induced lymphangiogenesis via upregulating autocrine secretion of VEGF-C in colorectal cancer, which is associated with the PI3K/Akt-dependent pathway., Study demonstrated that fibronectin inhibition and neutralization by specific antibody prevented significantly the adhesion of A. baumannii to human lung epithelial cells (A549 cells)., study concludes that increased serotonylation of fibronectin occurs in pulmonary hypertension, Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin, High expression of fibronectin is associated with esophageal squamous cell carcinoma., Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC)., Genistein attenuates advanced glycation end product-induced expression of fibronectin and connective tissue growth factor, Collagens regulate the EDA(+)-FN-ECM organisation at transcriptional and post-transcriptional level and activate the alpha5beta1-FAK complexes., Gene expression profiles showed that FN1 was up-regulated in epidermolysis bullosa subtypes., Reduced expression of two specific integrin subunits, alpha 5 andalpha V, resulted in the inability of MG63 cells to deposit fibronectin into their extracellular matrix, influenza A Virus entry with a alpha2,6-linked sialic acid binding preference requires host fibronectin, MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., FN1 assembly and the lung colonization of suspended CL1-5 cells were inhibited when endogenous A1AT protein was knocked down using siRNA., MSF functions in the metabolic remodeling of the tumor microenvironment., Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin., our results suggest that plasma PTPalpha and fibronectin may be associated with opisthorchiasis., Data indicate that fibronectin mRNA and protein levels were significantly down-regulated following the upregulation of serine protease HTRA1., Serum oncofetal fibronectin mRNA in differentiated thyroid carcinoma cannot identify those with metastatic disease., FN1 and ITGA4 are potential oral squamous cell carcinoma biomarkers for tongue/mouth floor and edentulous ridge., Data indicate that rheumatoid synovial fibroblasts have impaired adhesion and spreading on citrullinated fibronectin, but focal matrix degradation is unaffected by citrullinated fibronectin., We confirm WNT4, CDKN2BAS and FN1 as the first identified common loci for endometriosis., An algorithm based on fetal FN for management of preterm labor (PTL) does not reduce evaluation times for triage, hospital admissions or preterm deliveries., Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression in the U87 glioblastoma cell line, Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., Lactobacillus iners AB-1 displays a mechanism of vaginal persistence to human fibronectin, with implications for human reproductive health., Authors report that group A Streptococcus biofilm formation is mediated by the Scl1 interaction with extra domain A-containing cellular form of fibronectin., Data indicate that citrullinated fibronectin (cFn) plays a potential pathophysiologic role in rheumatoid arthritis (RA) by inhibiting apoptosis and increasing proinflammatory cytokine secretion of fibroblast-like synoviocytes (FLSs)., Data indicate that four different Anticalins all show low nanomolar affinities for fibronectin (Fn) extra-domain B (ED-B)., MOMCs were obtained on the fibronectin., Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of fibronectin., genome-wide association study of population in Northern Belgium, Data indicate that endopeptidase O (PepO) is a ubiquitously expressed plasminogen- and fibronectin-binding protein, which plays role in pneumococcal invasion of host cells and aids in immune evasion., The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8., Treated neutrophils aggregate on fibronectin (Fn)-coated wells and exhibit an exaggerated cell aggregation phenotype on wells coated with Fn plus beta-glucan., The metabolism of glucose through hexosamine biosynthetic pathway promotes O-glycosylation of the oncofetal form of FN during epithelial-mesenchymal transition modulating tumorogenesis., fibronectin is a key factor in human serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture., Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis., High glucose and AGEs can up-regulate the expressions of ROS and fibronectin in human mesangial cells by activating transcriptional co-activator p300., Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN)., Collagen association stabilizes a distinct monomeric fibronectin gelatin-binding domain conformation in solution., Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer., The predicted 23-residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with the tenth FN type III domain., We identified 31 interactors from plasma, of which only seven were previously known to interact with fibronectin, Data indicate tht mRNA expression of elastin, procollagen I type I, fibronectin, Col1alpha1, and TIMP-1 had a significant increase after bicyclic[1,2,3]triazoles plus UVA treatment, while the MMP-1 decreased, compared with the UVA irradiated group., We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, MSF expression was upregulated in NSCLC tumors and promoted migration and invasion in A549 cells., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, Four members from clusters of the miR-200 family (miR-200a/-200b/-429 and miR-200c/-141), epithelial-mesenchymal transition could potentially play a role in the pathogenesis of pterygium., Low extra domain A fibronectin expression is associated with bacterial meningitis., The SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Data suggest that determination of the fibronectin content can serve as a prognostic biomarker for breast and prostate cancers and possibly other cancers., Together these results show that FN produced by the tumor cells has a role in glioblastoma multiforme pathophysiology and they provide insights into the implications that targeting FN interactions may have for combating this dreaded disease., profile of fibronectin fragmentation and alterations of fibronectin domain immunoreactivities in seminal plasma may influence their engagement in the fertilisation process, First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for gestational diabetes., We demonstrate that the high FN content of the endometrium matrix, and not specifically the EDA domain, supports trophoblast invasion by showing that forced incorporation of plasma FN (EDA-) promotes efficient trophoblast invasion, Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy., Perturbing the mesenchymal regulators, platelet-derived growth factor (PDGF) receptors or fibronectin, reverts mesenchymal stromal/stem cells (MSCs) toward mesodermal progenitors with endothelial potential., cFN isoform expression in the TM ECM may be a novel pathologic mechanism involved in the TM changes associated with glaucoma., expression of miR-206 and its target gene, fn 1, may contribute to the progression of bronchopulmonary dysplasia, Fibrillins require the complete gelatin-binding region of fibronectin for interactions., Fibronectin is upregulated in a subset of nasopharyngeal carcinomas , and its increased immunoexpression significantly correlated with advanced features, justifying the potentiality of fibronectin as a theragnostic biomaker of nasopharyngeal carcinomas ., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., the dual antibody approach utilizes commercially available antibodies and simple immunohistochemistry, thus making it accessible to a wide range of scientists interested in fibronectin mechanobiology, Oncofetal fibronectin levels are potentially useful as a biomarker for urothelial inflammation and repair., Eppin and Fn bind to each other in human semen and on human ejaculated spermatozoa., Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens., Identify FN1(high)MITF(low) cell type in melanoma associated with ischemic necrosis, and propose these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment., This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in Duchenne muscular dystrophy patients., Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis., Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5., Data indicate that ibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA) is sterically regulated by fibronectin binding., Most of these motifs are located on the F1 and F3 faces of the Hap passenger domain structure, suggesting that the F1 and F3 faces may be responsible for the Hap passenger domain-fibronectin interaction., Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition, We proved that the CD157-fibronectin interaction occurs with living cells, where it elicits CD157-mediated cell responses., MMF could inhibit MCP-1 expression and the secretion of FN, indicating that it may delay the progression of glomerulosclerosis and interstitial fibrosis in diabetic nephropathy to ultimately achieve protective effects on the kidney., Data indicate the expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in cardiac tissue from heart transplant recipients., The mean level of cellular fibronectin expression in cases with liver fibrosis was significantly higher than the corresponding level in cases with liver cirrhosis., rFN/CDHs may induce hMSCs differentiation into osteoblasts and PLGA/collagen nanofibers loaded with rFN/CDHs have potential in bone tissue engineering., The AT heterozygote in FN-1 (rs940739A/T) was found to be significantly associated with knee osteoarthritis in 2 case-control studies. FN-1 rs6725958C/A was significant only if both studies were combined., Results found that the majority of colorectal cancer cases with depressed tumors had a higher frequency of elevated FN1 expression., High fibronectin expression is associated with thyroid papillary carcinoma follicular variant., the possible regulatory effect of fibronectin peptides in liver fibrosis was further supported by the ability of these peptides to induce metalloprotease-9 (MMP-9) expression in human monocytes., homophilic fibronectin binding peptides might have novel applications in the field of tissue regeneration as tools to regulate neovascularization via VEGF signaling, serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells., Study tested the role of the histone acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon; these data suggest that histone acetylation could be one of the mechanisms how promoter and promoter binding proteins influence alternative splicing., Data indicate that the IL-33/ST2 protein pathway may promote airway remodeling in asthma through activating HLF-1 fibroblast to over-express fibronectin 1 (FN1) and type 1 collagen (Col1)., fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis, These results have indicated that the cysteine proteinase of Trypanosoma cruzi metacyclic forms, through its fibronectin-degrading activity, is implicated in host cell invasion., PEDF inhibited breast cancer cell migration and invasion by down-regulating fibronectin, Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour., Data indicate that the interaction between the alpha4beta1 integrin and the EDA domain of fibronectin helps to drive tissue fibrosis by promoting a contractile phenotype and an increase in fibronectin synthesis and deposition., The expression of terminal sugars on milk FN is different from that of plasma FN of the lactating mother and is associated with milk maturation., Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells., Fibronectin gene expression has a potential role in the pathogenesis of keloid., Genetic induction of fibronectin by HER2 triggers cell adhesion and invasion capacities., Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin and collagens by a laminin-rich matrix, we describe a new type of hybrid molecules including 10th type III human fibronectin domain (10Fn3) - one of the alternative scaffold proteins which can be used for the construction of antibody mimics with various binding specificity, Serum fibronectin was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. Fibronectin increased with nephropathy severity., Fn Msp iv polymorphism appeared to be associated with diabetic nephropathy susceptibility., Serum- and CSF-FN levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis., These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway., Data show that the amount of the the extra domain-B (EDB) splice variant of fibronectin (FN) produced by endothelial cells increases with matrix stiffness., The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, An observed increase in PLD activity was mediated through boosting the binding of PLD with dynamin which in turn facilitated fibronectin-induced cell spreading., Asthmatic human bronchial epithelial cells are intrinsically primed to produce more fibronectin, which when deposited into the extracellular matrix, is capable of driving remodeling and inflammation., The pathogenic H5N1 and H7N9 influenza virus variants cause more severe deregulation of NRF2 and fibronectin in host epithelial cells than the less pathogenic H1N1 variant., Study determined the structure of third type III domain, 3FN3 using nuclear magnetic resonance spectroscopy, and investigated its stability, folding, and unfolding., polymorphisms in rs6725958, rs10202709, and rs35343655 of the Fn gene had no obvious effect on the susceptibility to the development of calcium oxalate stones in the Uighur population, residing in the Xinjiang region of China., Fibronectin binding to heparan sulfate mediates exosome-cell interactions in Myeloma., the correlation between placental DNAm of INHBA/FN1 and maternal serum INHA/FN1 levels indicate that DNAm may be a useful tool to identify novel biomarkers for adverse pregnancy outcomes in some cases., that strong FN1 promoter activity drives inappropriate expression of the biologically active portion of EGF, These results suggest novel functions of endogenous FN involved in immune evasion and maintenance of hepatitis b virus replication.,
OFFICIAL_GENE_SYMBOL FN1,
OMIM_DISEASE Glomerulopathy with fibronectin deposits 2, Plasma fibronectin deficiency,
SP_COMMENT alternative products:Additional isoforms seem to exist, developmental stage:Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age., disease:Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life., function:Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth., online information:Fibronectin entry, PTM:Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)., PTM:It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated., PTM:Sulfated., similarity:Contains 12 fibronectin type-I domains., similarity:Contains 16 fibronectin type-III domains., similarity:Contains 2 fibronectin type-II domains., subunit:Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7., tissue specificity:Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.,
integrin subunit alpha V(ITGAV) integrin subunit alpha V(ITGAV) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q31-q32,
ENSEMBL_GENE_ID ENSG00000138448,
GENERIF_SUMMARY integrin alphavbeta3 is shown to interact with PECAM-1, Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin, Acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18., Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI)., They analyzed the expression of these cell surface receptors in nine ovarian cancer cell lines and also in the primary human ovarian surface epithelial cell line (HOSE)., Chemotaxis and chemoinvasion analyses revealed a dose-dependent increase in prostate cancer cell movement induced by osteopontin and a strict dependence of cell invasion on alphavbeta3 integrin function., Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3), Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)., Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins., Acute cellular rejection following human heart transplantation is associated with increased expression, existence of an alpha V integrin/vitronectin connection in hepatocellular carcinoma and suggest that this connection may be an adverse prognostic factor., Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma., integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells, Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells, alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts, phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement, promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2, identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins, induced alpha(v)beta(8) integrin expression mediated Fas-stimulated migration, identification of functional segments within the beta2I-domain, Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif., role in mediating pro-angiogenic activity of CYR61, An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis., in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin, thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin., Overexpression of integrin alphaV promotes human osteosarcoma cell populated collagen lattice contraction and cell movement., activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2, Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, has a role in the early phase of liver metastasis, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, role in regulating cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells, decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures, Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies, tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner, Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development., signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis., Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, These data provide evidence for a functional role for integrin alphavbeta8-mediated activation of transforming growth factor-beta in control of human airway epithelial proliferation in vivo., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone, Disulfide bonding patterns of the integrin alpha V chain are described; the alpha chain displays differences in the disulfide patterns of those bonds near their C-terminal regions linking the heavy and light chains., alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, alphav subunit cleavage is essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47, alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., integrin alpha(v)beta(6) is an RGD-dependent receptor for Coxsackievirus A9 and may be important in natural Coxsackievirus A9 infections, alpha-v integrin signals through JAB1 (Jun activation binding protein 1) to prolong MMP1 production, secondary structure analysis of integrin alphaVbeta3, CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas, Integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling., alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix, The Integrin alphaV receptor is members of the group of the cellular adhesion molecules (CAM), are heterodimeric transmembrane glycoprotein receptors involved in processes such as cell-cell and cell-matrix adhesion, cell migration and signaling., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele, We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution., We conclude that integrin alphavbeta6-dependent MMP-2 and -9 up-regulation is an important feature of increased migration in hypoxic human keratinocytes., Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling., urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, new pair of adhesion molecules, Thy-1 and alphavbeta3, inditified that mediate the interaction of melanoma cells and activated endothelial cells, IGROV1 cells were shown to adhere rapidly on the HUVECs monolayer; adhesion was inhibited by anti-alphav integrin and anti-Vn blocking antibodies, but not by anti-beta1 integrin antibodies, Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3, May contribute to the formation of arteriovenous malformaions in younger patients., melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Alphavbeta6 integrin down-regulates MMP-13 expression in oral squamous cell carcinoma cells., Increased transcripts of activators of TGFB1 (Itgav and Thbs1), and genes that are activated by TGFB1 (Spp1, Timp1, and Tnc) occurs during acute lung injury, Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells., alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis, Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption, These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., thymosin beta10, but not thymosin beta4, have direct inhibitive effects on endothelial migration and tube formation that might be mediated via downregulation of VEGF, VEGFR-1 and integrin alphaV in HCAECs., While tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and alphavbeta5 maintains the DC's tolerogenic profile., Findings suggest that in melanoma cells the increase in MMP-2 activity, CD44 surface expression, and cell migration is integrin alpha V-dependent., The effects of the EBV nuclear antigen 3C on the activities of Nm23-H1 via GATA-1 and Sp1 are reported., Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells., PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry., S 36578-2 is highly selective for alpha v beta3 and alpha v beta5 integrins and induces detachment, caspase-8 activation, and apoptosis in human umbilical endothelial cells, These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the epithelial-mesenchymal trophic unit (EMTU).[integrin alphavbt=eta6, integrin alphavbeta8], Relevance of betaIG-H3 and alpha v beta3 integrin-interacting motifs as potential therapeutic targets in rheumatoid arthritis., integrin binding loop of Foot-and-mouth disease virus has most likely evolved for binding to alphavbeta6 with a higher affinity than to alphavbeta3 and alphavbeta8, The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells., identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, Mn(2+) promoted convergent changes in integrin alphavbeta6 conformation and Fb structure through activation of ERK/MAPK and MMP-9, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Adhesion of breast cancer cells through the VLA integrins alpha2beta1 and alpha5beta1 was significantly reduced by an apoptosis-inducing natural triterpenoid, dehydrothyrsiferol (DT), when studied on low amounts of extracellular matrix., Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development., Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation, Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion., Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway., The rs3738919-C allele of the ITGAV gene is associated with rheumatoid arthritis in the European Caucasian population, suggesting ITGAV as a new minor susceptibility gene for rheumatoid arthritis., establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy, c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells, These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., Results show that the tyrosine phosphatase protein-tyrosine phosphatase mu dephosphorylated PIPKIgamma and thus canceled the PIPKIgamma-dependent activation of integrin alpha(v)beta(3) by blocking the interaction of integrin alpha(v)beta(3) with talin., the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)., Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules., anti-tumor and anti-metastatic activities of CNTO 95 in breast cancer models and provide insight into the cellular and molecular mechanisms mediating its inhibitory effects on metastasis., Signal transduction pathways underlying the enhanced cell migration reveal that the IGF-I-IGFBP-VN complex stimulates a transient activation of the ERK/MAPK signaling pathway and a sustained activation of the phosphatidylinositide 3-kinase/AKT pathway., uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, Alpha v beta 5, alpha v beta 5 and their ligands Del-1 and L1 play an important role in the process of tumor cells moving from the original place., TGF-beta1 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of chondrosarcoma cells, We used suppression subtractive hybridization (SSH) to study molecular signature of melanoma progression, by showing characteristics of early neoplastic lesions including expression of KISS1, lack of alphavbeta3-integrin and low levels of RHOC., Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression., The role of alpha(v)beta(3) and Fas as the mediators of streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is described., Integrin alpha v beta 3 plays a critical role in the S1P-stimulated chemotactic response of ECs, The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., T(3) and T(4) hormones rapidly stimulate ERK activation in MG-63 cells via integrin alpha(V)beta(3) and that one functional effect of this ERK activation is increased DNA synthesis, Mn(2+) simultaneously modulates the thiol isomerase activity of protein disulfide isomerase that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation, Data show that in preeclamptic pregnancies, histamine does not stimulate expression of integrin alphaVbeta3, as it does in uncomplicated pergnancies., These results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with cytomegalovirus., Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window., results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, There was significant relationship between integrin alpha-v subunit expression and lymphatic metastasis of laryngeal and hypopharyngeal squamous cell carcinoma., ROCK-dependent actomyosin-driven contractility is a critical determinant for the regulation of the interaction between Necl-5 and integrin alpha(V)beta(3)., significant difference in the expression of the beta(3) integrin subunit between primary glioblastomas compared with low-grade gliomas, expression of ITGAV was significantly correlated with differentiation and metastasis of the laryngeal and hypopharyngeal carcinomas; down-regulation of ITGAV gene could inhibit proliferation of Hep-2 cells and induce to its apoptosis., integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, Alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation., osteopontin, integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, Integrin alphavbeta3 is not significantly implicated in the anti-migratory effect of anti-angiogenic urokinase kringle domain, overexpressed in endometrial carcinomas, especially with high grade and in lymph node metastases, ability of ovarian carcinoma cells to bind to peritoneal mesothelium in vitro and strongly suggest that vitronectin and its receptors contribute to this crucial event., SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway., The apo(a) component of Lp(a) signals through integrin alphaVbeta3 to activate endothelial cells., urokinase-derived antagonists of alphavbeta5 integrin activation inhibit migration and invasion of carcinoma cells, These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion., VWF strings bind specifically to integrin alpha(v)beta(3) on human endothelial cells, Analogous to EAE, in subjects with MS, we found increased expression of Opn in DCs and increased expression of the Opn receptors CD44, beta(3), and alpha(v) on T cells., M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., in cutaneous nodular melanomas, necrosis was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin & poor patient outcome, analysis of how the different antiangiogenic potential of resveratrol stereoisomers is related to their different capacity to affect alphavbeta3 integrin function, These data suggest that Coxsackievirus A9 binding to alphaVbeta6 is a high-affinity interaction, which may indicate its importance in clinical infections, pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Data show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK, Src and VE-cadherin, increased cell permeability and decreased cell adhesion in endothelial cells., In neuroendocrine tumors, gene-expression integrin alphaV was highly variable, The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Compound 4, having the DGR retro-sequence, is a low micromolar ligand for the alphavbeta5 integrin., Data demonstrated significantly upregulated integrin-linked kinase as a function of alphavbeta3 in two ovarian cancer cell lines, and proved co-localization at the surface of alphavbeta3-overexpressing adherent cells., These data strongly indicate that KAI1 may suppress ovarian cancer progression by inhibiting integrin alphavbeta3/vitronectin-provoked tumor cell motility and proliferation as important hallmarks of the oncogenic process., Down-regulation of alphav integrin by retroviral delivery of siRNA significantly reduced drug resistance of colon tumor cells & xenografts, indicating that ITGAV plays an important role in MCR to oxaliplatin in colon cancer cells., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., In metastatic brain lesions carrying activated alpha(v)beta(3), VEGF expression is controlled at the post-transcriptional level and involves phosphorylation and inhibition of translational respressor 4E-binding protein (4E-BP1)., Tumors express alpha(v)beta(6) suggest that this probe has significant potential for the in vivo detection of the malignancy., VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of integrin alphavbeta6 expression and activation of ERK., Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3, Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, These data are the first demonstration of conformational coupling of the integrin alphaVbeta3 leg and head domains, and suggest that inside-out activation may involve conformational changes other than the postulated switch to a genu-linear state., upregulated expression in lung adenocarcinoma cells following bacterial infection, Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, Data show that leberagin-C can inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins., This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor., Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Data show that under basal conditions, sphingosine kinase-1, integrin alpha(v)beta(3), and CD31 exist as a heterotrimeric complex which is required in SK-1-mediated endothelial cell survival., Association of ITGAV SNP rs7378919 with rhuematoid arthritis was not replicated in New Zealand or Oxford case control sample sets, alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, suggest that a divalent metal-ion coordination was a common driving force for the formation of both SDV/alpha v beta 3 and RGD/alpha v beta 3 complexes., GPIIb/IIIa and alphavbeta3 integrins are important mediators in the pathology of cervical cancer., VEGFR-2 was significantly upregulated by alpha-v suppression in HUVEC & downregulated in HMVEC at mRNA & protein levels. Suppression of alpha-v can either augment or inhibit VEGFR-2 levels & VEGF-induced proliferation in EC from different vascular beds., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., The angiogenic effects of leptin are mediated by circulating angiogenic cells and involve src kinase dependent phosphorylation of integrin alphavbeta5., Blocking integrin alpha V beta 3 inhibits differentiation and subsequently tumor formation., Reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic brain arteriovenous malformations., Definitive endoderm highly express the integrins alphaV and beta5, which have the ability to bind to vitronectin., Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes., OPN and its receptor integrin alphanubeta3 may be involved in the pathogenesis of preeclampsia., Mast cell-bronchial smooth muscle cell adhesion involved collagen, CD44, and CD51, particularly under inflammatory conditions., Data show that PLT adhesion to HIMEC was ICAM-1, FKN and integrin alpha(v)beta(3) dependent., Expression of integrin alphaVbeta3 on T lymphocytes does not predict its endometrial expression., Results proved the importance of VEGF and integrin alphavbeta3 in the pathogenesis of AML., Ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation., These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions., the Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation are mechanistic consequences of endothelial Ang-2 stimulation, Alpha(V)beta(6), but not alpha(V)beta(3), blocked human parechovirus 1 cellular infectivity., Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression., A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., Integrin alphavbeta3 and Lewis Y, which is contained within it, are expressed in secretory-stage endometrial tissue., Integrin alphavbeta5 is a primary receptor for adenovirus., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., immunohistochemistry of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin as targets for contraceptive approaches or understanding of the pathogenesis of infertility offer little benefit compared with histological dating, demonstrate that alphaVbeta3 ligation results in sustained increases of PI3 kinase/Akt-dependent binding of transcription factor NF-kappaB to DNA., Periostin could be a biochemical marker of the early stromal response associated to breast cancer bone metastasis formation., PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5., Preincubation of macrophages with HMGB1 decreased their ability to engulf apoptotic neutrophils or thymocytes. Soluble alphavbeta3 integrin, but not soluble alphavbeta5 integrin, prevented this inhibition., These results demonstrate that HMGB1 blocks alpha(v)beta(3)-dependent recognition and uptake of apoptotic cells., Data showed that EhPCP5 RGD motif is a ligand for alpha(V)beta(3) integrin-mediated adhesion on colonic cells and represents a novel mechanism to trigger an inflammatory response in the pathogenesis of intestinal amebiasis., Saturation transfer difference NMR was applied to the interaction of the integrin alphavbeta6 with a known peptide ligand and highlights novel contact points between the substrate and target protein, TNF-alpha enhances the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the MEK/ERK/NF-kappaB signal transduction pathway., The mRNA levels of IntegrinalphaV and Integrinbeta8 were significantly higher in LSCC tissues than that in corresponding adjacent normal tissues., Leptin stimulates the migration of human prostate cancer cells via transcriptional up-regulation of alphavbeta3 integrin expression., Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins., TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the alphaVbeta6 integrin, an important regulator of transforming growth factor-beta1 activation., beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection., ITGAV is a genetic determinant for the severe progression of primary biliary cirrhosis in Japanese patients, When polymorphonuclear leukocytes are recruited to tumor cells in a tumor microenvironment, alphaVbeta3 and intercellular adhesion molecule (ICAM)-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circulation., Integrin alphav is the main CAM subunit of uterine leiomyomas that involve angiogenesis, The authors demonstrated that both integrins alphavbeta6 and alphavbeta8 can serve as specific receptors for Epstein-Barr virus gHgL proteins., ITGAV is present in all cortical layers, the striatum and Purkinje cells. It is known to be involved in cortical development, the role of acidic extracellular pH in regulating activation of integrin alpha(v)beta(3)., PET of alphavbeta3-integrin and alphavbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy., data demonstrated that (18)F-fluciclatide detected changes in tumor uptake after acute antiangiogenic therapy markedly earlier than any significant volumetric changes were observable., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., chemokine receptor 7 regulates cell adhesion and migration via integrin alpha v beta 3 in metastatic squamous cell carcinoma of the head and neck, S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Alpha v integrin was expressed at robust levels in tumor cells representing less differentiated, more invasive components of squamous cell carcinomas, Performed molecular dynamics to simulate forced unbending of a complete integrin alpha(v)beta ectodomain in both unliganded and liganded forms., Our findings indicate that alphavbeta5 integrin may be involved in the change that occurs in monolayer-cultured chondrocytes after plating, Direct contact between tumor cells and human epithelial-like stem cells treated with DMBA increased integrin alpha V expression and caused local activation of the transforming growth factor (TGF)-beta1/Smad signaling pathways., Integrin alphavbeta3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors, With increased tension cytoskeletal stress fibers develop that contain alphaSMA and alphavbeta3 integrin that replaces alpha2beta1 integrin, consistent with cell switching from collagen to non-collagen proteins interactions., IL-8 increases integrin alpha V expression and cell motility in human chondrosarcoma cells, Data suggest that lung fibroblast chemokine secretion directs dendritic cell trafficking, in a manner that is critically dependent on alphavbeta8-mediated activation of TGF-beta by fibroblasts., Data showt targeting of alpha(v)-integrin by GLPG0187 can inhibit both de novo formation as well as progression of bone metastases in prostate cancer., The mechanism of decreased cell migration, a prerequisite for metastasis and invasion, due to increased CAR expression may be explained by reduced alphavbeta3 integrin expression., Integrin alpha(nu) beta(3), NTRS1 and PSCA mRNA expression increased with tumorigenic potential, but mRNA expression levels for these proteins do not translate directly to equivalent expression levels of membrane bound protein., Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis., analysis of alpha(nu)beta(3) integrin expression by (64)Cu- and (68)Ga-labeled RGD conjugates, The alphav integrins are an important group of adhesion molecules involved in the migration and invasion of tumour cells., Overexpression of integrin alphav in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis, The authors report that integrin alphavbeta5 can also bind to Epstein-Barr virus gHgL and trigger fusion., alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, an important role of PTTG in regulation of integrins alpha(V) and beta(3) and adhesion-complex proteins leading to induction of EMT, Chromosomal regions of homozygous loss, encompassing the ITGAV and RUNX1 gene, were detected in multiple samples indicating a potential role in the carcinogenesis of esophageal adenocarcinoma., Integrin-alphavbeta3 was upregulated on various therapy-resistant tumor cells through chronic activation of ATM/Chk2-and NFkappaB-mediated pathways, Data show that alphav integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion., Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., MIF enhanced the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the PI3K/Akt/NF-kappaB signal transduction pathway., Disulfide bonds in EGF domains of beta3 affect structure and function of alphaIIbbeta3 and alphavbeta3 integrins in different manner., Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells., Further characterized the intermolecular interactions between alphavbeta3 integrin and hormone analogues. Data reveal T(3) and T(4)ac bind in two different modes, occupying two alternate binding sites on alphavbeta3 integrin., knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Collectively, our results indicate that FAS1 domain protein, in addition to its inhibitory effect on alpha5-beta-3 integrin-mediated angiogenesis, also inhibits VEGF165-induced angiogenesis, In vivo, we found that irradiation combined with alphaV integrin blocking treatment significantly enhanced the radiosensitivity of NPC xenografts, alpha5 endothelial cell-transgenic knockout mice display an attenuated angiogenic response which correlates with delayed endothelial proliferation; primary alpha5KO brain endothelial cells in culture exhibit delayed growth and proliferation., our findings indicate that alphavbeta6 and TGF-beta act in a common tumor suppressor pathway, Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through alphav-integrin membrane translocation, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., CD44 signaling regulates phosphorylation of RUNX2. Localization of RUNX2 in the nucleus requires phosphorylation of Smad-5 by integrin alphavbeta3 signaling., The Protein kinase D (PKD) mediates signals from the platelet-derived growth factor receptor (PDGF-R) to control alphavbeta3 integrin recycling., thioridazine regulates endothelial cell functions that are relevant to angiogenesis through the suppression of the alphavbeta3/FAK/mTOR signaling pathway, Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity., The results demonstrate a non-redundant role for alpha(v)beta(3) in gremlin-induced angiogenesis., observations suggest that the lack of simultaneous binding of metal ions to all three betaI domain sites in alphaVbeta3 is most simply explained as an artifact of crystallization conditions, Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer., Consistent with prediction, docking simulation studies of fractalkine's chemokine domain show direct interaction with integrins alphavbeta3 and alpha4beta1 at very high affinity., overexpression of the ITGAV gene and protein was correlated with an increased risk of perineural invasion in colorectal cancer., propose that alphavbeta3-integrin is considered a class of non-TLR pattern recognition receptors., alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration, RGD peptide plays an important role in the modulation of cell motility and in the perturbation of cell attachment affecting the malignant potential of breast cancer cells via binding to integrin alphavbeta3., CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength, CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways., Integrins alphavbeta3 and alphavbeta5 and their ligands are expressed in distinct and heterogeneous patterns in primary and secondary central nervous system neoplasms., integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma, study demonstrate that binding of integrin alphavbeta5 and alpha defensin 5 have opposite effects on the elastic response of adenovirus type 35, revealing a direct link between virus-host interactions and the mechanical properties of the capsid, alphavbeta8 integrin, via interactions with RhoGDI1, regulates activation of Rho proteins to promote glioblastoma multiforme cell invasiveness., Increased alphavbeta6 integrin expression is associated with poor prognosis and decreased survival in oral squamous cell carcinoma patients., Data indicate that EGFL7 and integrin alphavbeta3 integrin colocalized in vesicular structures in uman umbilical vein endothelial cells (HUVECs)., Our data indicate that expression of [alpha]v[beta]3 in tumor cells and vessels is dependent on tumor grade, and that its expression in tumor cells may have a prognostic impact., the integrin avb6 plays an important role in the fusion of endosome/lysosome in corneal epithelial cells; inhibition of avb6 results in corneal epithelial barrier dysfunction., Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells., Results show that stromal cell-derived factor-1 (SDF-1) enhanced ovarian cancer cell invasion through alphavbeta6 integrin-mediated urokinase-type plasminogen activator (uPA) expression via the p38 MAPK and PI3 K/Akt pathway., Data indicate CCN1 can induce actin reorganization, formation of lamellipodia, and cell migration/invasion through the alphaV integrins/Rac1/ERK signaling axis; these CCN1-dependent activities can be effectively suppressed by monoclonal antibody YM1B., The coupling of extracellular matrices to integrin alphaV is necessary for Glioma initiating cell differentiation., Interaction of vitronectin with integrin alphavbeta3 results in the continued activation of the kinase mTOR., the expression of Lewis y antigen, integrin alphav and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction., PDGFRalpha CD51 cells in fetal bone marrow represent a small subset of CD146 cells expressing Nestin and enriched for mesenchymal stem cell and hematopoietic stem cell niche activities., The alphavbeta5 integrin-FAK-mediated pathway regulates phagocytosis in trabecular meshwork cells and this pathway is inhibited by activation of alphavbeta3 integrins., A switchblade-like movement of the integrin leg is indispensable for the affinity regulation of alphaVbeta3 integrin., We report a protein expression profile in high-grade osteosarcoma associating beta5 integrin, FAK, and GSK3beta that significantly correlates with poor response to neoadjuvant chemotherapy., Interaction between CCL2 and CCR2 enhances migration of prostate cancer cells through an increase in alphavbeta3 integrin production, Real-time imaging of alphav integrin molecular dynamics in human 143B osteosarcoma cells in vitro and in vivo, is reported., The level of OPN expression in lung adenocarcinoma was associated with decreased apoptotic activity of tumor cells, and correlated with alphav integrin expression, particularly in low stage tumors., GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent, upregulation of alphavbeta6 on myoepithelial cells generates a tumor promoter function through TGFbeta upregulation of MMP-9. These data suggest that expression of alphavbeta6 may be used to stratify patients with DCIS., Brain metastases ITGAV expression exhibits considerable heterogeneity according to tumor origin., Complement C3, vitronectin, and apolipoprotein A-I were further confirmed by western blotting, and the results showed that their contents decreased significantly after transient limb ischemia., alphavbeta6- and alphavbeta8-integrins acted independently and are thus interchangeable as receptors for Herpes simplex type 1 virus entry., Results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of rheumatoid arthritis., findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells, [(18)F]Galacto-RGD PET/CT shows specific tracer accumulation in human atherosclerotic carotid plaques, which correlates with alphavbeta3 expression., Inhibition of integrin alphavbeta3 results in significant inhibition of trophoblast attachment., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., High integrin alphaVbeta3 expression is associated with hepatocellular carcinoma., cilengitide can significantly down-regulate ITGAV expression and inhibit cell proliferation in laryngeal cancer cells, it will also to induce cell apoptosis through caspase-3 pathway., Expression of Gli1 and alphavbeta6 inversely correlates in tumours in vivo, and Hh targeting up-regulates TGF-beta1/Smad2/3-dependent alphavbeta6 expression, promoting pro-tumourigenic cell functions in vitro., Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, The use of LIF in combination with alphanubeta3 integrin as biomarkers appears to be superior to integrin testing alone when evaluating endometrial receptivity, primarily because of its earlier pattern of expression during the secretory phase., Overexpression of integrin alphav is associated with advanced T and N stage and as an independent prognostic factor in colorectal carcinoma., In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav., This co-targeting strategy relies on the interaction of MMP-2 with integrin a(v)b(3), which are known to associate via the hemopexin domain of MMP-2, These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3., The increased surface expression of alpha5beta1 integrin, along with the adhesion between the cells and fibronectin, could be inhibited by both ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) kinase inhibitors, Data show that chemokine domain of fractalkine (FKN-CD) can activate alphavbeta3 integrin in the absence of fractalkine receptor CX3CR1, but that this activation requires the direct binding of FKN-CD to alphavbeta3., Studies sugggest that the effect of integrin alphavbeta3 in the whole process of brain function recovery merits further study., Coimmunoprecipitation studies and proximity ligation assays indicated that integrin alphavbeta3 interacts with herpes simplex virus type 2 glycoprotein H (gH)., Herpesvirus 8 attachment and entry are dependent on alphaVbeta3 integrin localized to specific cell surface microdomains., alphavbeta3 was necessary and sufficient for Slug activation, the present study demonstrated that the link between systemic inflammatory markers and the ITGAV-rs3911238 polymorphism allele in Iranian RA patients., Expression of alphav integrin subunits seem to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases., The levels of integrin alpha(nu)beta(3) between normal skin and hypertrophic scar tissues were compared, and integrin alpha(nu)beta(3) was found to be upregulated in hypertrophic scar., overexpression of integrin alphav induces integrin alphavb8 heterodimer formation and the binding of integrin alphavbeta8 to type collagen might enhance the proliferation and invasion of SCC cells via the activation of the MEK/ERK signaling pathway., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., Inhibition of tumor-associated alphavbeta3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo., Low NAMPT is associated with upregulation of alphavbeta3 integrin in breast tumor cells., The importance of interaction between EDIL3 and integrin alphaV., The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion., Exogenous ATX controls breast cancer cell proliferation, invasion, and endothelial cell transmigration via interaction tumor integrin alphaVbeta3., post-treatment of peptides derived from the full-length tail or from the turn motif did not reverse aIIb and aV integrin activation., Unique sites of interaction between alphavbeta6 and uPAR are most likely located in uPAR domains II and III., The identification of integrin alphavbeta6 in a subset of DCIS presents a unique way to stratify patients with DCIS into those who may or may not progress to more serious disease., Integrin alphav promotes the proliferation of the human lung cancer cell line A549 by activating the ERK 1/2 signaling pathway, Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrin alphaVbeta3, integrin alphavbeta1, and integrin alpha4beta1., Integrin alphaVbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells., suggest that the OPN-integrin alphavbeta3 axis is crucial for 5-FU resistance in oral scandalous cell carcinoma, Integrin alphavbeta3 is required for cathepsin B-induced hepatocellular carcinoma progression, Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., high levels of alphavbeta6 integrin may identify a specific endotype of progressive fibrotic lung disease, Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., alphav integrin is required for efficient TGF-beta/Smad signaling and TGF-beta-induced breast cancer cell migration, and for maintaining a mesenchymal phenotype of the breast cancer cells., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with av- and a6-integrin expression, Our results show that the acquisition of metastatic competence by melanoma cells is accompanied by alteration of alphavbeta3 integrin glycosylation and that both avb3 and b1-6-branched sialylated complex-type N-glycans promote metastatic melanoma migration, These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK/Pyk2 signaling pathways., targeting eIF4E in integrin avb6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer., Herpes simplex virus entry is enabled by gH/gL interaction with alphavbeta6- or alphavbeta8-integrin receptors., ERK-mediated transcription regulation of the alphav monomer is regulated by T3. Thyroid hormones are potent alphavbeta3-ligands, driving ovarian cancer cell proliferation., The combined impacts of alphav-integrin and HER2 influence the invasive phenotype of breast cancer cells., These findings suggest that enhanced integrin alphavbeta3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-beta1-induced EMT in mammary epithelial cells., Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.,
OFFICIAL_GENE_SYMBOL ITGAV,
SP_COMMENT function:The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.,
integrin subunit beta 3(ITGB3) integrin subunit beta 3(ITGB3) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q21.32,
ENSEMBL_GENE_ID ENSG00000259207, ENSG00000259753,
GENERIF_SUMMARY Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF., Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity., A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function., Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3, Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI)., GPIIb-IIIa complexes are not in an activated conformational state after dissociation of abciximab unless there is an additional source of activation., beta3-Integrin expression was directly up-regulated by HOXA10 in the endometrium, location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron, A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia prevents GPIIbIIIa from binding fibrinogen when platelets are activated., Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3), Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton, Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)., Immunohistochemical analysis of human tumor sections from several organs showed a heterogeneus distribution of CD61 in metastatic cases from colon and breast carcinoma. However, no staining was found in metastasis from melanoma., Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton (integrin alpha(IIb)beta(3)), Site-directed mutagenesis of residues on the top surface of the integrin beta3 I-domain that contains a putative ligand binding site identified D158 and N215 as novel residues critical for ligand binding., Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins., A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia, collagen receptor glycoprotein VI and alphaIIbbeta3 trigger distinct patterns of receptor signalling in platelets, leading to tyrosine phosphorylation of PLCgamma2 (integrin alphaiibbeta3), Integrin alpha IIbbeta 3 has agonist-specific activation states and causes intrasubunit and intersubunit allosteric effects, Two different beta3 cysteine substitutions alter alphaIIb beta3 maturation and result in Glanzmann thrombasthenia., Integrin-linked kinase transiently associates with and phosphorylates beta3, regulating platelet integrin alphaIIb beta3 in a PI3-kinase dependent manner, Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma., integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells, Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells, Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes., Role for beta3 integrins in human melanoma growth and survival., alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts, regulation of integrin function by CD47 ligands, phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement, promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2, co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium, Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif., role in mediating pro-angiogenic activity of CYR61, An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis., in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin, thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin., a 17-amino acid sequence is identified as a common epitope for antibodies associated with quinine-induced immune thrombocytopenia, activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2, Ligand binding promotes the entropy-driven oligomerization of this protein, Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., role of Pro33 polymorphism in enhanced activation of mitogen-activated protein kinase and myosin light chain kinase, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, Integrin alphaiibbeta3 plays a role in signal transduction that leads to a defect in leukocyte adhesion, has a role in the early phase of liver metastasis, possible association between the GPIIb/IIIa PIA1/A2 polymorphism and the occurrence of cryptogenic stroke in young patients, data suggest that despite partial disruption of calf-1 or calf-2 domain by mutation in Glanzmann thrombasthenia, glycoprotein IIb/IIIa complex is formed but its transport from the endoplasmic reticulum is impaired, Review. A signal is initiated at the cytoplasmic tail to transform the extracellular domain of alphaIIbbeta3 into a functional receptor for fibrinogen or von Willebrand factor to support platelet aggregation & thrombus formation., thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures, Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies, Intercellular calcium communication is primarily mediated by a signaling mechanism operating between this protein, ITGA2B and the adenosine diphosphate purinergic receptor P2Y12., tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner, in megakaryocytes turbulence induces Rap1 activation that controls alphaIIbbeta3-mediated cell adhesion, role of polymorphisms in cardiovascular thrombotic disease [review], Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development., This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., binding of thrombin to GPIbalpha induces fibrin binding to resting alphaIIbbeta3 leading to fibrin-dependent platelet aggregation and clot retraction, that can be selectively inhibited by alphaIIbbeta3 antagonists, results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation; results also suggest a structural basis for the coincidence of integrin activation and clustering, the extracellular Ig domain of IAP(CD47), when bound to thrombospondin, interacts with integrin alphaIIbbeta3 and can change alphaIIbbeta3 in a high affinity state without the requirement of intracellular signaling, signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis., Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals., alphavbeta3 expression in LNCaP (beta3-LNCaP) prostate cancer cells causes increased cdc2 mRNA levels as evaluated by gene expression analysis, and increased cdc2 protein and kinase activity levels, identification of binding site in gamma C-domain of fibrinogen, alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, Low concentrations of agonists resulted in enhanced platelet aggregation in subjects with the GNB3 CC-genotype compared to carriers of a 825T-allele., relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation, analyzed the possible cooperation effect between the PlA2 allele (GPIIIa) and LL genotype (SLC6A4) in the development of myocardial infarction, high prevalence of the HPA-1b allele of beta3 in Glanzmann thrombasthenia, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, Individuals homozygous for the Leu33Pro polymorphism of the beta3 integrin subunit have an increased cancer risk., Glycoprotein IIb/IIIa has a role in platelet-activating factor-induced platelet activation with protein kinase C activity, the 749EATSTFT756N and 755TNITYRG762T regions of beta3 contribute to the regulation of alphaIIbbeta3 anchorage to the cytoskeleton and platelet spreading to an adhesive surface, beta3 integrin has a role in causing structural rearrangements of the 10-23 DNAzyme, predictions of hydrophilicity, surface accessibility and antigenicity and the three dimensional structure of the beta(3) integrin correlate with autoantibody binding to a recombinant GPIIIa peptide 'B' containing residues 468-691., increased expression of the alpha(v)beta(3) integrin during breast cancer progression can make tumor cells more responsive to malignancy-promoting ligands such as OPN and result in increased tumor cell aggressiveness., the E749ATSTFTN756 region of the beta3-tail stabilizes the binding of soluble and surface-bound ligand to integrin alphaIIbbeta3 via a mechanism that involves the phosphorylation of FAK, integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone, proteins regulated by CBFA2 are required for inside-out signal transduction-dependent activation of GPIIb-IIIa, results invoke a model whereby Src is primed for activation by direct interaction with an integrin beta tail, and integrin clustering stabilizes activated Src by inducing intermolecular autophosphorylation, The mutation at the position 29 107 of intron 10, G-->T, in the beta3 genomic DNA was found to induce an aberrant splicing and to be responsible for Glanzmann's thrombasthenia in this patient, activation of the beta subunit I-like domain of integrin beta3 is analogous to that of the alpha subunit I domain, Cysteine residues in the epidermal growth factor domains of the beta3 subunit are important for the ligand binding activity of the integrin alphaIIbbeta3 complex., CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47, alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells, in the absence of GPIbalpha or following inhibition of thrombin binding to GPIbalpha, there is a reduction in the thrombin-induced calcium flux, beta3 cleavage and micro -calpain activation., analysis of the three-dimensional model of integrin alphaIIbbeta3, APOC3, LPL and GpIIIa genes were found to be associated with BP levels. The contributions of these genes, although modest, are consistent with the polygenic nature of blood pressure levels., integrin alpha(IIb)beta3 adhesive function is regulated by platelet FXIII and calpain, This review discusses the major role played by glycoprotein IIb/IIIa (GPIIb/IIIa) in the regulation of platelet adhesion and aggregation during hemostasis., alpha IIb beta 3 signaling in platelets is regulated by SHIP1 and Lyn kinase, GpIIIa gene polymorphism as a risk factor for stroke caused by large vessel disease in males., results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect, For HPA-1 gene polymorphism, only the HPA-1a/a (PlA1/A1) genotype was observed in Korean population cardiac patients, secondary structure analysis of integrin alphaVbeta3, The HPA-1b (PlA2) allele significantly protected against subarachnoid hemorrhage., analysis of F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa in human platelets, Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor., beta3 integrins play important roles during transendothelial migration of PC3 cells while interacting with the matrix underneath the endothelium. These interactions are independent of the ability to cluster beta3 integrins into focal adhesions., CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas, PlA1/A2 polymorphism of platelet glycoprotein IIIa (GPIIIa) has is not implicated in the pathogenesis of type 2 diabetes., A novel 465T-->C (S123P) mutation in exon 3 interfered with the platelet aggregation in a manner similar to Glanzmann's thrombasthenia., Inheritance of the integrin beta3 Leu33Pro polymorphism may increase the breast cancer risk by age 45 in the German population., a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia, The Integrin beta3 receptor is expressed on almost all cells originating from the mesenchyme and seem to mediate several biological processes, including adhesion of osteoblasts to the bone matrix., Mu-calpain is activated in human endometrial cells during hypoxia and that subsequent cleavage of the integrin beta3 cytoplasmic domain may give some adverse effects to the function of human endometrium, Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele, there is a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion, integrin alphaIIbbeta3 has a role in mechanotransduction for shear activation of platelets, alphaIIb-mediated outside-in signaling resulting in TxA(2) production and granule secretion is negatively regulated by a sequence of residues in the membrane distal beta3 cytoplasmic domain sequence RKEFAKFEEER., association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene, Of the 22 Glanzmann thrombasthenia patients studied, mutations were detected in 12 individuals. Of these, 11 were novel mutations., We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution., This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens., dephosphorylation events play a role via serine/threonine phosphatases during the integrin outside-in signaling mechanism, and the Leu(33) --> Pro polymorphism regulates this process, Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling., variation in ITGB3 in addition to Leu33Pro could contribute to susceptibility to cardiovacular disease and serotonin in a sex-specific manner, Results support the hypothesis that carriers of the GP IIIa PlA2 allele might have an increased risk for acute coronary syndrome in Hungarian population., SHPS-1 negatively regulates platelet function via CD47, especially alpha(IIb)beta(3)-mediated outside-in signaling, TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B, an apparently silent beta3 mutation results in aberrant splicing and reduced beta3 mRNA and may play a causative role in Type I Glanzmann thrombasthenia, electron tomography analysis of the three-dimensional structure of integrin alphaIIbbeta3 in the active state, PI3-K and calcium oscillation are synergistically operated and form a positive-feedback regulation in integrin alpha(IIb)beta3-mediated outside-in signaling, Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3, reactive oxygen species produced in platelets significantly affected alphaIIbbeta3 integrin activation, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Highest expression of alphavbeta3 integrin is associated with metastatic potential of osteosarcoma cells by enhancing the ability of the cells to migrate specifically to the lung, the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets, GPVI and integrin alphaIIb beta3 have roles in signaling during platelet adhesion and platelet aggregation [review], Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells., ITGbeta3 subunit cytoplasmic domains require membrane anchorage and the NPXY motif to recruit to adhesion complexes, Data show that protein-tyrosine phosphatase (PTP)-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 integrin signaling in platelets., Glycoprotein IIIa allele has been found in many studies to associate with risk of thrombosis., alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy, The 177-184 sequence of beta3 is necessary for vitronectin binding to alphaVbeta3., Cells overexpressing beta3 integrin can bind human ADAM12 via beta3 integrin., PI3K and granular released ADP in coordinating the feedback regulations in integrin alpha(IIb)beta3-mediated platelet activation, beta3 knockout mice transfused with wild-type platelets generated specific anti-beta3 antibodies which were able to induce thrombocytopenia in wild-type mice., ITGB3 gene polymorphisms is associated with breast cancer, Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer., analysis of platelet integrin alphaIIbbeta3 structure and function (review), the beta3 integrin gene is the direct target of NFAT1 in osteoclast formation, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, three beta-propeller mutations do not affect the production of pro-alpha(IIb), its ability to complex with beta3, or its stability, but do cause variable defects in transport of pro-alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi, Our results did not show the causative relationship between the existence of platelets GP IIIa mutations and venous system thrombosis in the women in labor., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption, The endometrial expression of beta3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation., Inhibition of alphaIIbbeta3 activation by NAD(P)H oxidase inhibitors and superoxide scavengers was independent of NO/cGMP signaling demonstrating a direct role of platelet NAD(P)H oxidase-generated ROS for integrin alphaIIbbeta3 activation., T cells from kidney allograft recipients can express significant amounts of alpha-beta 3 integrin (CD41/CD61., These results establish the beta3 gene as a direct target of NFATc1 in RANKL-dependent osteoclast formation., Increase in the affinity of alphaIIb beta3-mediated cell adhesion through binding to calcium- and integrin-binding protein following agonist stimulation is impaired in patients because of mutations., the Pro33 isoform of purified integrin alphaIIbbeta3 has increased fibrinogen and prothrombin binding, P-selectin expression, but not activated GPIIb/IIIa, is enhanced in ADP-activated platelets in the inflammatory stage of Takayasu's arteritis. SELP may play a significant role in the inflammatory and thrombotic responses associated with intractable TA, Results describe the multifunctional behavior of integrins, including integrin beta 3, based on their modification potential at hydroxyl groups of amino acids as a source of interplay., while the C-terminal region of the alpha(IIb) tail minimally influences alpha(IIb)beta(3) activation, the C-terminal region of the beta(3) tail is critically involved, Data showed that ITGB3 and SLC6A4 expression levels are correlated., analysis of metal-binding sites in the integrin beta3 A-domain, we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018)., integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells., PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry., Results suggest that shear stress directly modulates alpha(IIb)beta(3) function and that the shear-induced signaling contributes to regulation of platelet aggregation by directing the release of constraining cytoskeletal elements from the beta(3)-tail., beta3 integrin alters TGF-beta signaling in mammary epithelial cells via Src-mediated TbetaR-II tyrosine phosphorylation, which significantly enhanced the ability of TGF-beta to induce epithelial to mesenchymal transition and invasion., interactions between alphaIIbbeta3 & ligands echistatin & fibrinogen's gamma-module; studies differentiate priming ligands, which bind to resting receptor & perturb its conformation, from regulated ligands, where binding-site remodeling must first occur, analysis of platelet integrin alphaIIbbeta3 mutations that may play a role in Glanzmann thrombasthenia, Protein kinase C delta is positively regulated by platelet alpha IIb beta 3 outside-in signaling in platelet function., Tyrosine phosphorylation of beta3 promotes integrin outside-in signaling, by which the timing and location of calpain cleavage of integrins are dynamically regulated., N-cadherin and beta3 integrin expression correlates with progression to advanced-stage melanoma., platelet alphaIIbbeta3 is activated by an exogenous peptide corresponding to the transmembrane domain of alphaIIb, The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells., Cell surface expression of alphavbeta5 resulted in an attenuation of alphavbeta3-mediated migration on vitronectin, results demonstrate differential modes of regulation of Dok1 and Dok2 in platelets, and raise the possibility that Dok2 plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3, Transduction of beta3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to denatured collagen (gelatin)., identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed, SLC6A4 and ITGB3 gene interactions have roles in autism etiology and in serotonin level determination, The ITGB3_Leu33Pro polymorphism may potentially increase the risk of ovarian cancer in Polish women with an inherited BRCA1 mutation., Inhibition of integrin alphavbeta3 leads to abrogation of migration of HSC stimulated with PDGF-BB and to an antifibrogenic gene expression pattern., Individuals homozygous for the integrin beta3 Leu33Pro polymorphism have a two-fold risk of hip fracture, mainly confined to postmenopausal women., T cells epitopes on Glycoprotein IIIa., data suggest that the Pl(A2) polymorphism is a genetic determinant of ischemic stroke in a selected high-risk hypertensive population, the surface density of fibrinogen affects alpha II b beta 3-mediated platelet signaling, adhesion, and spreading, All patients with ISSNHL should undergo a comprehensive hematologic investigation of inherited and acquired prothrombotic factors, including platelet and V Leiden mutations, to identify a subset of patients at high risk of recurrent HL., in patients with stable coronary artery disease, an increased platelet reactivity after exercise, is specifically associated with an increased expression of platelet GP IIb/IIIa receptor, No association between GpIIIa polymorphism with either type 2 diabetes or ST elevation acute myocardial infarction., Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development., This is the first demonstration that NO directly regulates integrin beta(3) phosphorylation., Discussion of recent developments in elucidating the mechanism of integrin activation, with particular focus on the platelet integrin alphaIIbbeta3, is provided in this review, activation of ITGB3 transcription required a HoxA10 domain that was not identical to the "hexapeptide" that mediates interaction of Hox and Pbx proteins, Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation, integrins alphaLbeta2 and alphaIIbbeta3 are activated by mutation of a conserved asparagine in the I-like domain, OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin., Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion., Data show that in bullous pemphigoid, beta3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway., Significant associations between single nucleotide polymorphisms in ITGB3 and asthma, wheezing, and IgE levels suggest an early role for this gene in the development of asthma and allergy., Glycoprotein IIIa (GPIIIa, platelet antigen A1 and A2) polymorphisms that contribute to resistance or augmented response to aspirin are rare in the Chinese population., HPA-3b homozygotes have a tendency to develop ST segment elevation myocardial infarction instead of non-ST segment elevation infarction or unstable angina in acute coronary syndrome., Expression of the human ITGB3 subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and cell proliferation., separation of transmembrane domains is required for integrin outside-in signal transduction, establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy, Regions of alpha(IIb) and beta(3) cytoplasmic tails, together with membrane segments of the subunits, contact each other to form a complex which restrains the integrin in a resting state. It is unclasping of this complex that induces integrin activation., c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., The PIA2 allele did not alter the beneficial effect of statins on blood coagulation., Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils, preliminary findings show that the HPA-6 A/B genotype is a risk factor for autoimmune thrombocytopenia in systemic lupus erythematosus, The proapoptotic ITGB3 cytoplasmic domain is rarely mutated in common human cancers and may not play an important role in the development of the cancers., Endometrial integrin beta3 and LIF expressions in the peri-implantation phase were significantly lower in stimulated cycles (including both moderate and high responders) compared to natural controls., Structural rearrangements undergone by integrin alpha(IIb)beta(3) after platelet activation were tested., effects of EDTA on GPIIb-IIIa dissociation and loss of adhesive functions are largely but not completely reve, macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells, analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton, Our findings show that A2/A2 homozygosity is associated with an increased risk of visual loss due to anterior ischemic optic neuritis in giant cell arteritis., Truncated beta3 may act as an anti-integrin and play a crucial role in cell migration, which is an important process in tumor invasion and metastasis., platelet glycoprotein IIb-IIIa number (evaluated as maximal binding of (125)I-labelled antibody CRC64) varied from 40.5 to 80.8 x 10(3) per platelet with no significant influence of platelet glycoprotein III a(GP IIIa) genotype., Fourteen of the antibodies reacted with a 29-kDa GPIIIa fragment comprising only the GPIIIa hybrid and plextrin-semaphorin-integrin homology domains, The specificity-determining loop was removed from the betaA domain & the mutations for HPA-4b,& -8,-6, -7, -10,-11,& -16bw antigens were introduced. The structural basis for their reactions with HPA-4 & HPA-bw antibodies was determined., oxidant systems external to platelets did not activate GP IIb/IIIa receptors while increased intra-platelet iron was associated with appearance of cytosolic oxidizing species and with GP IIb/IIIa receptor activation, The precise nature of the integrin beta 3 domains involved in the HPA-1a epitopes was studied by creating 8 soluble peptides & modeling their structures & interations with HPA-1a antibodies. Residues outside the PSI and hybrid domains are required., The ITGB3 GCC-Pro33 haplotype was associated with enhanced vWF activity, which may indicate ITGB3 haplotype influences endothelial function., the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)., a structural change in the conformation of anti-GPIIIa49-66 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet fragmentation and aggregate dissolution, Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were found to be associated with the symptoms and recurrence of ischemic stroke., Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules., Novel ancestral mutation found in a cluster of Jordanian Glanzmann thrombasthenia patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3., Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma, uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, platelet activation and aggregation is regulated by MMP-2 that specifically interacts with integrin alpha(IIb)beta(3), Upon phosphorylation of Tyr 747 in the beta3 integrin tail, however, Dok1 then binds much more strongly than talin., Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon., the beta3 membrane-proximal and -distal residues cooperatively regulate talin-mediated alpha IIb beta3 activation., Functional and computational studies of the ligand-associated metal binding site of ITGB3 are reported., Data show that integrin beta3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of gastric carcinoma., Tyr178 of beta3 is critical for alphaIIb maturation and macromolecular ligand binding to alphaIIbbeta3, There was a significant association between the PlA2 polymorphism of GPIIIa and the risk of thrombosis in patients with HIT antibodies., tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin, data show that the integrin beta 3 262T>C silent mutation is not restricted to a single family, as initially suggested, Thermodynamic data demonstrate that entropy is the dominant factor stabilizing lphaIIbbeta3, Integrin alpha v beta 3 plays a critical role in the S1P-stimulated chemotactic response of ECs., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., T(3) and T(4) hormones rapidly stimulate ERK activation in MG-63 cells via integrin alpha(V)beta(3) and that one functional effect of this ERK activation is increased DNA synthesis, In conclusion, agglucetin, acting as a survival factor, promotes endothelial adhesion and angiogenesis by triggering alphavbeta3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway., The numbers of antibody-binding sites of CD41, CD41a, CD41b, and CD61 on platelets of aplastic anemia patients and in idiopathic thrombocytopenic purpura patients, the numbers of sites for CD41 and CD41a were less than in normal controls., support an unsuspected role of alphaIIbbeta3/serotonin transporter(SERT)associations as well as alphaIIbbeta3 activation in control of SERT activity in vivo, nature of the lipid headgroup affected only the intracellular part of the transmembrane helix, indicating that an asymmetric lipid distribution is not required for studying the beta3 transmembrane segment, Mn(2+) simultaneously modulates the thiol isomerase activity of protein disulfide isomerase that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation, RN181 associates with the platelet-specific integrin alphaIIbbeta3 in human platelets through the conserved alphaIIb cytoplasmic KVGFFKR motif., Protein phosphatase 2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway, This study evaluated whether there was an association between 2 polymorphisms--the platelet glycoprotein (GP) IIIa PlA1/A2 and the endothelial nitric oxide synthase gene and a risk for nonvariceal upper GI bleeding in patients taking low-dose aspirin., Data show that in preeclamptic pregnancies, histamine does not stimulate expression of integrin alphaVbeta3, as it does in uncomplicated pergnancies., Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window., results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, ROCK-dependent actomyosin-driven contractility is a critical determinant for the regulation of the interaction between Necl-5 and integrin alpha(V)beta(3)., HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Show that the Pl(A1/A2) polymorphism of Gp IIb/IIIa primarily affects the aggregation of platelets to monocytes in males., Data show no dramatic height change upon Mn(2+)-induced activation of membrane-bound integrins when compared with an inactive integrin control group., The results suggest that the intensity levels of platelet CD61 were elevated and associated with clinical phases and disease severity in patients with hemorrhagic fever with renal syndrome, CRP at levels found during episodes of inflammation directly binds to the activated form of alphaIIbbeta3 and inhibits platelet aggregation., integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling, Results identify kindlin-2 as a novel regulator of integrin beta3 activation; it functions as a coactivator., ITGB3 (beta3) DNA from a Va(a)-positive individual were sequenced and a single-nucleotide polymorphism (C622>T) in exon 5, resulting in the replacement of threonine with methionine at residue 195 was identified., Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses, osteopontin, Talin recruitment to alphaIIbbeta3 by RIAM mediates agonist-induced alphaIIbbeta3 activation, with implications for hemostasis and thrombosis., talin IBS2 binds to the same face of the beta3 subunit cytoplasmic helix as the integrin alphaIIb cytoplasmic tail helix, suggesting that IBS2 can only interact with the beta3 subunit following integrin activation., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, Ligand binding to platelet alphaIIbbeta3 induces integrin cytoplasmic domain-dependent phosphorylation of FcgammaRIIa, which then enlists selected components of the immunoreceptor signaling cascade to transmit amplification signals into the cell., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, GPIIIa Pl(A2) allele may be a genetic factor that contributes to the risk of sudden death from myocardial infarction in the absence of known risk factors, The presence of GPIIIa on this circulating trophoblast cellular material could be the source of HPA-1a alloantigen causing primary immunization of susceptible primigravidae, Factor XIII V34L, PAI-1, GPIIIa L33P, MTHFR C677T and MTHFR A1298C frequencies of genetic polymorphisms were found to be significantly higher among patients with idiopathic portal hypertension, the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas., The alphaIIb G236E mutation causes Glanzmann's thrombasthenia by impairing the association with beta3 during biogenesis of the receptor., UV-C appears to activate alphaIIbbeta3 not by affecting intracellular signal transduction, but by reduction of disulfide bonds regulating integrin conformation., SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway., The apo(a) component of Lp(a) signals through integrin alphaVbeta3 to activate endothelial cells., alpha3 integrin, despite its ability to respond to alternate ligands after wounding, does so through a single structure, the filopodia., Splenic macrophages that take up opsonized platelets via FcgammaRI are major APCs for cryptic GPIIb/IIIa peptides, and are central to the maintenance of anti-platelet autoantibody production in ITP patients, This report analyzed the molecular effects of an A>T substitution leading to an amino acid change, D217>V, in the beta3 integrin gene identified in patients with variant Glanzmann Thrombasthenia., four polymorphisms, GPIIIa, TAFI 147Ala>Thr, methylene tetrahydrofolate reductase (MTHFR) 677 C>T, and MTHFR 1298 A>C, showed significant association with Asian-Indian stroke patients below 15 years of age, ITGA2 807C>T polymorphism may be associated with reduced colorectal cancer risk., Mutation of the clasp region of alphav or beta3 results in a constitutively activated integrin, confirming the role of the extracellular clasp in restraining integrin activation., These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion., VWF strings bind specifically to integrin alpha(v)beta(3) on human endothelial cells, alpha(IIb)beta(3) provides a constitutive presence of factor H on platelets; activation of platelets increases platelet-bound factor which perhaps involves other binding sites for factor H on platelets., Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions., The genetic polymorphism glycoprotein IIIa leu33pro was significantly associated with CHD., Analogous to EAE, in subjects with MS, we found increased expression of Opn in DCs and increased expression of the Opn receptors CD44, beta(3), and alpha(v) on T cells., Rationally designed integrin beta3 mutants stabilized in the high affinity conformation., M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., HPA-1a alloantibodies have a direct effect on endothelial cell spreading and monolayer integrity., in cutaneous nodular melanomas, necrosis was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin & poor patient outcome, analysis of how the different antiangiogenic potential of resveratrol stereoisomers is related to their different capacity to affect alphavbeta3 integrin function, Integrin beta3, like E-cadherin, may be also a suppressor gene down-regulating invasive features of ovarian cancer cells in SKOV3 cell subclones., Ligation of alpha(IIb)beta(3) by immobilized ligands during platelet adhesion induces a transmembrane conformation change in the integrin, resulting in unclasping of the complex between the membrane-proximal parts of cytoplasmic tails., Transient expression of integrin beta(3) in SMMC-7721 resulted in an enhanced level of apoptosis and suppression of colony formation., pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration, H. pylori ureB antibody could cross-react with human platelet GP IIIa and partly inhibit platelet aggregation. UreB may be a crucial component of H. pylori involved in the pathogenesis of a subset of ITP., Eptifibatide-dependent antibodies engage the integrin beta3 subunit so that FcgammaRIIa and its downstream signaling components become activated, resulting in thrombocytopenia and a predisposition to thrombosis., Beta3 integrin expression within uterine endometrium may have a role in unexplained infertility, Pyk2 is a critical signalling molecule downstream of beta3 integrin tyrosine phosphorylation and mediates Vav1 recruitment to accomplish actin reorganization necessary for adhesion, Data show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK, Src and VE-cadherin, increased cell permeability and decreased cell adhesion in endothelial cells., gene-expression levels of the key angiogenesis molecules VEGF and integrin beta3 were lower in neuroendocrine tumors than in colorectal liver metastases and were highly variable, These results confirm the impact of polymorphism A2 (PLA2) in platelet glycoprotein IIb/IIIa on recurrent spontaneous abortion in the period of 10 to 20 weeks of gestation., Reduced ITGB3 expression is reported in platelets hyposensitive to catecholamines when activated with TRAP., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Glycoprotein IIB/IIIA inhibitor to reduce postpercutaneous coronary intervention myonecrosis and improve coronary flow in diabetics, only indirect evidence of replication (using LD-tagging SNPs) was observed for three genes (PHF11, IL10, and ITGB3)., The structurally unique, highly conserved integrin alphaIIbbeta3 transmembrane complex rationalizes bi-directional signalling and represents the first structure of a heterodimeric TM receptor complex., HPA-3 but not HPA-1 polymorphism may be one of the inherited risk factors associated with the susceptibility of hantavirus infection and the disease severity of HFRS., Three heterozygous mutations were identified in the genes encoding platelet integrin receptor alphaIIbbeta3 in a patient with an ill defined platelet disorder, Data demonstrated significantly upregulated integrin-linked kinase as a function of alphavbeta3 in two ovarian cancer cell lines, and proved co-localization at the surface of alphavbeta3-overexpressing adherent cells., The novel autosomal dominant macrothrombocytopenia associated with platelet dysfunction raises interesting questions about the role of integrin beta(3), and its betaTD domain, in platelet formation and function., The GpIIIa A1/A2 polymorphism is not a risk factor of aneurysmal subarachnoid haemorrhage in a Polish population., The conformational dynamics of the I-like and Hybrid domains from the beta3 integrin headpiece showed that these two helices function in tandem to initiate large-scale, interdomain conformational transition apparent in integrin activation and signaling., Data show that intermediate filament recruitment to focal adhesions in endothelial cells requires beta3 integrin, plectin and the microtubule cytoskeleton, and is dependent on microtubule motors., The results suggest that Greek carriers of the HPA-1b allele with hypertension may be at increased risk for developing end-stage renal disease., These data strongly indicate that KAI1 may suppress ovarian cancer progression by inhibiting integrin alphavbeta3/vitronectin-provoked tumor cell motility and proliferation as important hallmarks of the oncogenic process., mutations in platelet GlyIIIaA1/A2 were found in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease, The regulation of EC junctional integrity involves the coordinated and dynamic modification of localization and activity of junctional stabilizers such as the integrin beta(3) and the destabilizer, JAM-C., Activating effect of PLAA1/A2 polymorphism of GPIIIa gene and 677T/T polymorphism of MTHFR gene on morphofunctional state of platelets is proved., Comparison of frequencies of genotypes of polymorphism A1/A2 of GPIIb/IIIa gene in combined sample of population and group with SCD revealed in SCD group lowering of portion of A2/A2 homozygotes, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., GPIIIa PlA2 polymorphism was frequent (27.5%), but the homozygous variant was very infrequent (0.5%). The presence of PLA2 had no influence on peri-procedural or one-year clinical outcomes., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Multiple approaches converged on the same structure of the resting integrin's transmembrane heterodimer, and this conformation likely reflects the integrin's native structure., High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism, In metastatic brain lesions carrying activated alpha(v)beta(3), VEGF expression is controlled at the post-transcriptional level and involves phosphorylation and inhibition of translational respressor 4E-binding protein (4E-BP1)., Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis., High expression of integrin beta3 and OPN in ectopic endometrium of adenomyosis may cause endometriotic lesions., the SLC6A4 and ITGB3 gene interaction may have a role in autism, inhibition of integrin beta3 in radioresistant pancreatic cancer cells could enhance adenovirus-mediated gene therapy., Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3, review focuses on the structure and function of the beta3 integrins, in particular alphaIIbbeta3, with reference to other integrins where relevant.[review], Integrin beta3 interacts with Galectin-3 in regulating endometrial cell adhesion., Altogether these data suggest that integrins alpha2 and alpha v beta 3 do not play a major role in the rotavirus entry process., Emphasizing the postulated role of myeloma cells in multiple myeloma bone disease; their osteoclast-like activity is regulated, at least in vitro, by the beta(3) subunit of the integrin., Results demonstrated that the growth inhibition of HEC1A cells by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., 22 novel mutations were identified in 45 unrelated Glanzmann thrombasthenia patients. Analysis of family members showed heterozygous mutations in all families, Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, These data are the first demonstration of conformational coupling of the integrin alphaVbeta3 leg and head domains, and suggest that inside-out activation may involve conformational changes other than the postulated switch to a genu-linear state., Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, initial activation-independent platelet adhesion to VWF via GPIb is resistant to NO, however, NO inhibits GPIb-mediated activation of alpha(IIb)beta(3) and MLC leading to reduced platelet spreading and aggregation., In a Croatian population, the gene frequencies of the HPA-1 alleles are 1a-0.854 & 1b-0.146., The authors demonstrate that the F0 domain of kindlin-1 is required for the ability of kindlin-1 to support talin-induced alphaIIbbeta3 integrin activation and for the localization of kindlin-1 to focal adhesions., while a point mutation in the clasp interface modestly activates alphaIIb beta3, additional mutations in the transmembrane interface have a synergistic effect, leading to extensive integrin activation, Data show that leberagin-C can inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins., This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor., Data show that under basal conditions, sphingosine kinase-1, integrin alpha(v)beta(3), and CD31 exist as a heterotrimeric complex which is required in SK-1-mediated endothelial cell survival., BCL-6-transfected breast cancer cell lines expressed significantly higher levels of CXCR4, Itgbeta-3 and FLT-1., An A-to-C SNP at Nt 487 in exon 3 (lysine-to-glutamine substitution at position 137) & a G-to-A SNP at Nt 1960 of exon 11 (glutamic acid-to-lysine substitution at position 628) were associated with neonatal alloimmune thrombocytopenia., alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, Results describe the role of the membrane distal region of human beta(3) integrin cytoplasmic tail in platelet aggregation, secretion, alpha(IIb)beta(3) activation and fibrinogen binding., The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers., suggest that a divalent metal-ion coordination was a common driving force for the formation of both SDV/alpha v beta 3 and RGD/alpha v beta 3 complexes., GPIIb/IIIa and alphavbeta3 integrins are important mediators in the pathology of cervical cancer., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., Oxidatively modified fibrinogen showed less binding activity than native fibrinogen to GpIIb/IIIa coated micro beads and human platelets whereas slightly higher binding capacity to ADP induced stimulated platelets, Patients with VWD carrying defective alleles of ITGB3 (1565T/C) showed milder phenotypes than expected., Data suggest a role for GPIIbIIIa integrin in caspase-3 activation induced by these platelet agonists., These data provide a mechanism for enhancement of platelet activity by alpha(IIb)beta(3) inhibitors, but also reveal a potentially important signaling pathway operating from the integrin to GPVI signaling., analysis of ITGA2B and ITGB3 mRNA splicing, expression, and structure-function relationship in Glanzmann thrombasthenia, Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes., provide the first proof that talin binding is sufficient to activate and extend membrane-embedded integrin alphaIIbbeta3, thereby resolving numerous controversies and enabling molecular analysis of reconstructed integrin signaling., study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA, the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes, Variant type Glanzmann thrombasthenia caused by homozygous p.724R>X mutation in beta3 integrin., In CAD patients receiving daily low dose of aspirin, there is a significant and independent association between the expression of GPIIIa PlA1 allele and the occurrence of persistent platelet hyperactivity detected with PFA-100, Here, the authors determined that pathogenic hantaviruses bind to quiescent platelets via a beta(3) integrin-dependent mechanism., The ITGB3 Leu33Pro amino acid substitution seems to be unrelated to the development of oxaliplatin-induced peripheral neuropathy, but it appears to be related to its severity., results presented here strongly suggest that MMP-2 interacts with alpha(IIb)beta(3) to regulate the shedding of CD40L exposed on the surfaces of activated human platelets, Results proved the importance of VEGF and integrin alphavbeta3 in the pathogenesis of AML., the interaction between Trp110 of alphaIIb and Arg261 of beta3 is critical for alphaIIbbeta3 integrity and outside-in signaling-related functions, in the presence of alphavbeta3-integrin Rac1 is not required for tumor angiogenesis, analysis of the effect of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3, GPIIIA gene (PI a allele) polymorphism efects on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease., Study helps define the pathophysiology of two rare ITGB3 mutations giving rise to GT, and describe the first patient with a qualitative alphaIIbbeta3 deficiency with both inhibitory and partially activating amino acid substitutions on the beta3 subunit., Demonstrate associations between ischemic stroke functional outcome and 2 COX-2 variants (rs20417 and rs5275) and a GPIIIa variant (rs5918)., These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions., a mutation in alphaIIbbeta3 integrin may have a role in Glanzmann thrombasthenia [case report], the Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation are mechanistic consequences of endothelial Ang-2 stimulation, Frequency of glycoprotein IIIa gene variants that cause HPA-1 genotyping discrepancies., Alpha(V)beta(6), but not alpha(V)beta(3), blocked human parechovirus 1 cellular infectivity., The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, structure and mechanism of action of seems to depend on discrete transitions and to be more tightly coupled to the local environment than previously thought, [REVIEW] structure for the IIbbeta3 cytosolic domain heterodimer as it might exist in resting IIbbeta3 and protein interactions provide a background for understanding the pathogenesis of genetic bleeding disorder, A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin alphaIIbbeta3 to fibrinogen., immunohistochemistry of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin as targets for contraceptive approaches or understanding of the pathogenesis of infertility offer little benefit compared with histological dating, We have determined crystal structures of the alpha(IIb)beta(3) headpiece in the absence of ligand, Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation., Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain., glycoprotein IIIa PlA1/PlA1 genotype carriers have a significantly increased risks of acute vascular ischemic events associated with a poor prognosis at 1 year., The alphaIIbbeta3 deficiency of the proband was caused by two compound ITGA2B mutations, which were first reported in Chinese Glanzmann thrombasthenia patients., These results demonstrate that HMGB1 blocks alpha(v)beta(3)-dependent recognition and uptake of apoptotic cells., two orthogonal events regulate integrin alphaIIbbeta3's interactions with fibrinogen, Data showed that EhPCP5 RGD motif is a ligand for alpha(V)beta(3) integrin-mediated adhesion on colonic cells and represents a novel mechanism to trigger an inflammatory response in the pathogenesis of intestinal amebiasis., genetic polymorphism is associated with an increased risk of cardiovascular adverse events, TNF-alpha enhances the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the MEK/ERK/NF-kappaB signal transduction pathway., Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design., Leptin stimulates the migration of human prostate cancer cells via transcriptional up-regulation of alphavbeta3 integrin expression., our results collectively support the hypothesis that alphavbeta3 integrin has dual actions depending on the cell environment, and provide additional evidence on the role of integrins in pancreatic cancer, findings indicate that Glycoprotein IIIa leu33pro polymorphism is associated with early, spontaneous miscarriage., Data suggest that the GPIIIa and FcgammaRIIa platelet receptor polymorphisms do not influence S. aureus-platelet interactions in vitro or the clinical course of infective endocarditis., Streptococcus gordonii binding to the alpha(IIb)beta(3)/FcgammaRIIa integrin/ITAM signaling complex results in platelet activation that likely contributes to the thrombotic complications of infective endocarditis., Expression of integrin beta3 and its ligand tenascin-3 decrease the expression of uPA through p38MaPK in breast neoplasms., There was a significant association between a common ITGB3 haplotype and autism spectrum disorder., Role of integrin beta 3 polymorphisms in embryo implantation and placentation., case report of anterior ischemic neuropathy in Crohn's disease with homozygous C677T genetic polymorphism and GPIIIa variant, When polymorphonuclear leukocytes are recruited to tumor cells in a tumor microenvironment, alphaVbeta3 and intercellular adhesion molecule (ICAM)-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circulation., Data show that the alphaIIb cytoplasmic domain is largely disordered, but it interacts with and influences the conformation of the beta3 cytoplasmic domain., ITGB3 is known to be expressed on the surface of astrocyte cells in the brain. It has been shown to play a role in various developmental processes, These data provide important quantitative and qualitative characteristics of alphaIIbbeta3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow., The ITGB3 1565T/C polymorphism was found to be negatively, associated with RPL., the role of acidic extracellular pH in regulating activation of integrin alpha(v)beta(3)., kindlin-2 promotes integrin b1 and b3 activation., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., Suggest that individuals with Leu33Pro polymorphism of the GPIIIa glycoprotein may be predisposed to increased risk of atherosclerotic plaque rupture., Single nucleotide polymorphisms of integrin beta-3 gene is not associated with colorectal cancer., GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role., TLR2/+596 genotype may influence the association between ITGB3 single nucleotide polymrophisms and mold sensitization in adults with asthma., IL-8 increases integrin beta 3 expression and cell motility in human chondrosarcoma cells, these studies suggest that ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer., alpha(v)beta(3) integrin has dual actions depending on the cell environment., A vicinal thiol-containing population of alphaIIbbeta3 provides redox sensitive sites for regulation of alphaIIbbeta3., Only the threonine 410 gets dephosphorylated, possibly in an integrin aIIbb3-dependent manner, beta3-integrin has an essential effect on tumor cell proliferation and progression, and may be a potential therapeutic target for the prevention of skeletal metastases of lung cancer., analysis of alpha(nu)beta(3) integrin expression by (64)Cu- and (68)Ga-labeled RGD conjugates, The PlA1/A2 polymorphism of the GpIIIa gene was associated with deep vein thrombosis in our Italian Behcet disease patients, but does not seem to increase the risk of DVT due to factor V Leiden or prothrombin gene G20210A mutations., Intact alphaIIbbeta3 integrin is extended after activation, We now look at the repertoire of ITGA2B and ITGB3 gene defects, reexamine the relationship between phenotype and genotype, and review integrin structure in the many variant forms., BMP-7 may exert anti-invasive actions by inhibiting TGF-beta-induced expression of integrin beta(3)., designed mutations at interface between alphaIIb-subunit thigh domain and beta3-subunit I-EGF2 domain to determine effect of this interface during integrin inside-out activation and outside-in signaling, alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Direct intracoronary bolus injection resulted in a more pronounced local inhibition of platelet function and a higher degree of GP IIb/IIIa receptor occupancy as compared to standard intravenous bolus injection., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., This case-control study identified 3 genes (CYP2C19, ABCB1, and ITGB3) and 2 clopidogrel-related factors (loading dose and proton pump inhibitors) that were independently associated with early stent thrombosis, we show that while wild-type kindlin-2 is capable of promoting integrin alpha2b/beta3 activation, Integrin-alphavbeta3 was upregulated on various therapy-resistant tumor cells through chronic activation of ATM/Chk2-and NFkappaB-mediated pathways, study here indicated that integrin alphaVbeta3 had lower affinity when the ADMIDAS was mutated, Studies indicate that mutations increase the activation state of alphaIIbbeta3 and interfere with megakaryocytopoiesis., the point mutation in the EGF-4 domain of beta(3) integrin is responsible for the formation of the Sec(a) platelet alloantigen and affects receptor function, Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., A mutation in the beta3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of alphaIIb beta3 to an active state., alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1., MIF enhanced the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the PI3K/Akt/NF-kappaB signal transduction pathway., KSHV induction of integrin beta3 is likely to be important for Kaposi's Sarcoma tumor formation, Recurrent mutations of ITGB3 is associated with Glanzmann thrombasthenia., Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age., Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa., Disulfide bonds in EGF domains of beta3 affect structure and function of alphaIIbbeta3 and alphavbeta3 integrins in different manner., signalling through increased NEDD9 levels requires integrin beta3 signalling, which leads to elevated phosphorylation of integrin beta3, Hantaan virus infection upregulated the expression of integrin beta3 and VEGFR2., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, In patients with DES, who require cessation of clopidogrel before surgery, bridging with GP IIb/IIIa inhibitors appears effective in preventing adverse cardiac outcomes but may be associated with bleeding in patients undergoing cardiac surgery., The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes., identified alphaIIbbeta3 integrin as a functional galectin-1 receptor in platelets, kindlins do not promote initial talin recruitment to alphaIIbbeta3, suggesting that they co-activate integrin through a mechanism independent of recruitment, describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, the role of gene polymorphism in both the thrombotic and fibrinolytic pathways in young Mexican individuals with STEAMI and suggest a synergistic effect between PIA2 and 4G allele., Disease duration of atopic myelitis is reflected in significantly higher GP IIb/IIIa values than in controls and involves the sensory system, with increased platelet aggregative function., Low concentration sclerosants activated platelets and released microparticles but inhibited platelet aggregation due to suppression of GPIIb/IIIa activation., results suggest that in some focal segmental glomerulosclerosis patients, disruption of the podocyte cytoskeleton and beta3 integrin-mediated podocyte attachment are driven by the TNFalpha pathway., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, We propose a new inside-out activation mechanism for integrin alpha(IIb)beta(3) and by inference, all of the integrins in their native cellular environment., The talin binding to the integrin beta3 transmembrane domain(TMD) alters the topology of the TMD, resulting in integrin activation., Loss of Integrin alphaIIbbeta3 is associated with Glanzmann's thrombasthenia., Expression of ITGB3 and leukemia inhibitory factor (LIF) in the peri-implantation endometrium does not change in women with unexplained recurrent pregnancy loss., These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality., study found in Mexican mestizo patients, the platelet GP IIIa PL(A1/A2) gene polymorphism does not lead to the sticky platelet syndrome phenotype, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., A similar genotype prevalence of ITGB3 was found in idiopathic sudden sensorineural hearing loss patients and controls. The PLA1/A2 polymorphism was also not associated with recovery., The findings confirm previous reports that low-avidity HPA-1a antibodies can cause neonatal alloimmune thrombocytopenia but show that the presence of such an antibody does not predict that an infant will be affected., thioridazine regulates endothelial cell functions that are relevant to angiogenesis through the suppression of the alphavbeta3/FAK/mTOR signaling pathway, Agonist stimulation, talin-1, and kindlin-3 are crucial for alpha(IIb)beta(3) activation in a human megakaryoblastic cell line, CMK., Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer., Contrary to suggestions from previous studies, fractalkine chemokine domain binds directly to integrins alphavbeta3 abd alpha4beta1 at a very high affinity., propose that alphavbeta3-integrin is considered a class of non-TLR pattern recognition receptors., alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration, RGD peptide plays an important role in the modulation of cell motility and in the perturbation of cell attachment affecting the malignant potential of breast cancer cells via binding to integrin alphavbeta3., The A2A2 genotype of the glycoprotein IIIa polymorphism was not associated with MI risk in Caucasians with type 2 diabetes., PPP1C isoforms have distinct contribution to the outside-in alphaIIbbeta3 signalling-dependent functions in HEK293 alphaIIbbeta3 cells., CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength, These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen., An independent impact of PL A1/A2 polymorphism on risk of stillbirth development is not be yet established but additive role of the polymorphism in combination with other thrombophilic factors should be considered., Integrins alphavbeta3 and alphavbeta5 and their ligands are expressed in distinct and heterogeneous patterns in primary and secondary central nervous system neoplasms., the PI3 kinase/Rap1 pathway is intrinsically impaired in platelets from JAK2V617F-positive essential thrombocythemia patients, resulting in diminished thrombin and thrombopoietin-mediated integrin alpha(IIb)beta(3) activation, These results suggest that alphavbeta3-IGF1 interaction, not alphavbeta3-extracellular matrix interaction, is essential for IGF signaling., Results show that mutation in integrin beta3 contributes to thrombocytopenia through gain of function mechanisms, carriage of e2/e3/e4 for polymorphism of the apoE gene, does not influence on predisposition to the longevity., The activation capacity of integrin alphaIIbbeta3 integrin was diminished in myelodysplastic syndrome platelets., The PlA2-allele of the gene encoding platelet glycoprotein-IIIa has been found to be associated with short-term cognitive dysfunction after cardiac surgery., Data indicate that EGFL7 and integrin alphavbeta3 integrin colocalized in vesicular structures in uman umbilical vein endothelial cells (HUVECs)., Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation., Results revealed that rs3809865 was significantly associated with asthma due to its effect on the binding of hsa-mir-124 to ITGB3., show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function, dRP is a novel autocrine amplifier of platelet activity, which acts on platelet redox levels and modulates integrin alphaIIbbeta3, A dual mechanism of alphaIIb-beta3 inactivation via calpain(-2) cleavage of integrin-associated proteins and via TMEM16F-dependent phospholipid scrambling with an assistant role of mPTP formation., A single disulfide bond disruption in the beta3 integrin subunit promotes thiol/disulfide exchange, in a molecular dynamics study., The study concludes that the association between PLA1/A2 polymorphism of the GPIIIa gene and the tendency to inherit migraine with aura appears significant., Integrin alphaIIbbeta3 was fully activated, independent of the morphological state of human platelets., This review focuses on the biology of integrin alphaIIbbeta3, the major membrane protein on blood platelets., results of the present study indicate likely involvement of ITGB3 and TPH2 in the pathophysiology of ASD in the Indian population., Data indicate that nuclear integrin alphav monomer in T4-exposed cells, but not integrin beta3, bound to promoters of specific genes that have important roles in cancer cells., the expression of Lewis y antigen, integrin alphav and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction., Itgb3 is dispensable for normal hematopoiesis but is required for leukemogenesis., Review/Meta-analysis, A switchblade-like movement of the integrin leg is indispensable for the affinity regulation of alphaVbeta3 integrin., Interaction between CCL2 and CCR2 enhances migration of prostate cancer cells through an increase in alphavbeta3 integrin production, Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., Meta-analysis showed that ITGB3 SNPs are associated with age at onset in schizophrenia., study provides evidence that (99m)Tc-RGD-4CK is a promising agent for noninvasive determination of alphabeta3 integrin status and therapy monitoring in BAC, Results show a constitutive interaction between Src kinase and beta3 integrin through its SH3 domain and the phosphorylation of tyrosine in beta3 prevents this interaction., Studies indicate that Glanzmann thrombasthenia (GT) is caused by quantitative or qualitative deficiencies of alphaIIbbeta3, an integrin coded by the ITGA2B and ITGB3 genes., Spry4 overexpression resulted in decreased integrin beta3 protein levels in a post-transcriptional manner in part by modulating its tyrosine phosphorylation by c-Src. Spry4 knockdown increased integrin beta3 protein levels and tyrosine phosphorylation., ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells., Patients with the ACE DD genotype plus 1 or 2 unfavorable genotypes, the AT1R No-AA, the GPIIIa No-a1a1 or a combination of both, have twice higher the risk of MACE during their clinical follow-up., PA2 allele represents a risk factor for ST elevation myocardial infarction in young Mexican individuals but not for idiopathic ischemic stroke, ITGB3 expression is significantly lower in the endometrium of adenomyosis patients than in controls, GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent, Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation., HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells., These results demonstrate that serine/threonine phosphatases, probably PP2A, regulate both inside-out and outside-in mechanisms of signal transduction and clot retraction through Platelet Glycoprotein GPIIb-IIIa Complex in human platelets., Herpes simplex virus gH/gL sufficed to elicit type I IFN and NF-kappaB activation via alphavbeta3 integrin in epithelial and neuronal cell lines., Data indicate that mutations in alphaIIbbeta3 integrins decreased ligand binding and adhesion., Our data indicate an important role for the region that links the distal calf-2 and beta-tail domains to their respective transmembrane (TM) domains in transmitting the conformational changes in the TM domains associated with inside-out activation., Direct binding of Galpha13 to integrin beta3 mediates outside-in signaling and thrombus formation., these results establish that GP IIb/IIIa and alphavbeta3 integrins are essential mediators of shear flow-induced cancer cell mechanotransduction, The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.Kindlins have little direct effect on alphaIIbbeta3 integrin monomer affinity., Gene expression analysis in CHO cells reveals that the ITGB3 P189S mutation stabilizes alphavbeta3 despite preventing alphaIIbbeta3 expression., Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach., among patients undergoing elective percutaneous coronary intervention, the polymorphism Leu33Pro of platelet glycoprotein IIIa is associated with increased risk of periprocedural myocardial infarction only in diabetic patients, Swing-out of the beta3 hybrid domain is required for alphaIIbbeta3 integrin priming and normal cytoskeletal reorganization., [(18)F]Galacto-RGD PET/CT shows specific tracer accumulation in human atherosclerotic carotid plaques, which correlates with alphavbeta3 expression., PLA polymorphism of platelet integrin receptor, GpIIIa glycoprotein, (PLA polymorphism of the ITGB3 gene) is associated with the risk of myocardial infarction and CHD especially in young subjects., the study revealed no association between the risk of clopidogrel resistance and the presence of polymorphic variants of platelet receptor genes P2RY12 and GpIIIa., MiR-320a down-regulation mediates bladder carcinoma invasion by targeting ITGB3., Data indicate the role of vinculin in inducing the talin mediated integrin activation., It is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects., Among patients undergoing percutaneous coronary intervention for acute coronary syndromes, the polymorphism Leu33Pro of platelet glycoprotein IIIa is not associated with increased risk of periprocedural myocardial infarction., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding., SNP polymorphism of GP IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele)cannot be regarded as a risk factor for coronary or carotid atherosclerosis., Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa complex transmembrane/C-terminal domains and talin-1 in cell membrane environment during platelet activation., The use of LIF in combination with alphanubeta3 integrin as biomarkers appears to be superior to integrin testing alone when evaluating endometrial receptivity, primarily because of its earlier pattern of expression during the secretory phase., genetic polymorphism of the GP IIIa gene was associated with aspirin resistance in a very elderly Chinese population, Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, Data show that chemokine domain of fractalkine (FKN-CD) can activate alphavbeta3 integrin in the absence of fractalkine receptor CX3CR1, but that this activation requires the direct binding of FKN-CD to alphavbeta3., The alphaII b tail sequences distal of GFFKR participate in talin-mediated inside-out alphaII b beta3 activation through its steric clashes with beta3 -bound talin, Intermolecular transmembrane domain interactions activate integrin alphaIIbbeta3., It plays a role in regulation of leukocyte migration to a site of inflammation., A novel soluble integrin beta 3 variant in the plasma of acute myeloid leukemia patients is described., Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells., Studies sugggest that the effect of integrin alphavbeta3 in the whole process of brain function recovery merits further study., Coimmunoprecipitation studies and proximity ligation assays indicated that integrin alphavbeta3 interacts with herpes simplex virus type 2 glycoprotein H (gH)., Data suggest that endometrial levels of ITGB3 are down-regulated in women with unexplained recurrent pregnancy loss as compared to women with normal fertility during mid-secretory phase., knockdown of miR-378a increased the expression of its target proteins, vimentin, and beta3 integrin, which accelerated fibroblast migration and differentiation in vitro and enhanced wound healing in vivo., ITGB3 is downregulated 5-fold by silencing of laeverin in trophoblasts, reducing cell migration and invasion., These findings offer an explanation for the variable occupancy of the metal ion at LIMBS in alphaVbeta3 structures in the absence of ligand and provide new insights into the mechanisms of integrin regulation., diabetic retinopathy is associated with ITGA2/ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), The data presented here appears to demonstrate an increased risk of myocardial infarction in carriers of the PlA1/A2 polymorphism of glycoprotein IIIa, with an association that becomes stronger as age decreases., The totality of published data supports the hypothesis that carriage of the PlA2 polymorphism of GPIIIa is a risk factor for ischaemic strokes, and specifically those of cardioembolic and large vessel origin, Unlike the L33P substitution, the L33V transition would not affect the structure flexibility of the beta3 knee, and consequently the functions of alplhaIIbb3, High Integrin alpha3beta1 expression is associated with bladder cancer., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, Data show that thyroid hormones induce mitogen-activated protein kinase (MAPK) via integrin alphavbeta3 in bone marrow-derived cells from multiple myeloma (MM)., Herpesvirus 8 attachment and entry are dependent on alphaVbeta3 integrin localized to specific cell surface microdomains., Studied expression heterogeneity of ITGB3 and BCL-2 in lung adenocarcinoma tissue and adenocarcinoma cell line., In human breast cancer cells, alphavbeta3 was necessary and sufficient for Slug activation, Expression of the alphavbeta 3 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases, 33Leu --> Pro substitution of GPIIIa does not influence the prevalence and extent of angiographically defined coronary artery disease in general population, although apparently playing a role among younger patients., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., Although our positive results are not definitive, they suggest small effect associations of the ITGB3 gene with both ASD diagnosis and symptoms of echolalia, The methylation levels in the promoter regions of OPN and integrin beta3 genes in the vascular smooth muscle cells of varicose veins are reduced and the protein expression of OPN and integrin beta3 are increased, compared with normal veins., Report novel ITGB3 mutations causing Glanzmann thrombasthenia., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2., Conclude that tumour, rather than stromal, beta3 expression is essential and is required early for efficient spontaneous breast cancer metastasis to bone and soft tissues., Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events., ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population., Prevalence of alleles of polymorphic variants Leu33Pro and Leu66Arg gene ITGB3 among inhabitants of Siberia.The highest frequency of abnormal PLA2 allele (22.1%) and the PLA2/PLA2 genotype (8.8%) was observed among women, who had miscarried., suggest that the OPN-integrin alphavbeta3 axis is crucial for 5-FU resistance in oral squamous cell carcinoma, Integrin 3 modulates cell migration in an MMP2-dependent manner., Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3., These data identify a role of kindlin-3 phosphorylation in integrin b3 activation and provide a basis for functional differences between kindlin-3 and the two other kindlin paralogs., Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol relative to zwitterionic lipids in a headgroup structure-dependent manner., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., polymorphisms in human ITGB3 may contribute to the differential responsiveness of select patients to SSRIs., This observation suggests partitioning of the activated fibrinogen bound alphaIIbbeta3 into cholesterol rich domains is not responsible for the integrin clustering observed., Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., Cells with beta3-betaTD_del or beta3-C560R mutations had abnormal cytoplasmic extensions on immobilized fibrinogen or Von Willebrand factor. The active conformation of alphaIIbbeta3 can induce cytoskeletal rearrangements that lead to impaired proplatelet formation., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., beta 3 -Integrin inhibits LPS-induced autophagy in cardiomyocytes., Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B) and 68 novel missense variants in integrin beta 3 (ITGB3)., these results highlight ECO/siITGB3 nanoparticles as a promising therapeutic regimen to combat Triple-negative breast cancer, These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK/Pyk2 signaling pathways., MiR-320a inhibits metastasis in salivary Adenoid cystic carcinoma by targeting ITGB3 and may serve as a therapeutic target and prognostic marker in salivary cancers., results demonstrate that beta3 integrin expression depends on the source of the fibroblast and that its expression inhibits alphaSMA expression (and thus the myofibroblast phenotype)., IL-8 activates the PI3K/Akt pathway, which in turn activates NF-kappaB, resulting in the upregulation of integrin beta3 expression and increased invasion of estrogen receptor-negative breast cancer cells., ITGB3 expression increased with matrix rigidity. Blocking Ibeta3 reduced Gli2 and PTHrP expression. Ibeta3 co-localized with TGF-beta RII on rigid but not compliant films., Integrin alphanubeta6-mediated MMP-9 secretion facilitates pericellular matrix degradation at high cell density, promoting invasive growth of colonic neoplasms., T4, but not T3, controls integrin's outside-in signaling by phosphorylating tyrosine 759 in the beta3 subunit. ERK-mediated transcription regulation of the b3 monomer is regulated by T3 and T4which are alphavbeta3-ligands driving ovarian cancer cell proliferation ., GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively)., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, Data show that immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins., Ibrutinib causes GPVI and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding., Up-regulation of integrin beta3 is associated with endometrial cancer., Activated but ligand-free integrins exist mainly in the compact conformation, whereas fibrin-bound alphaIIbbeta3 predominantly exists in a fully extended, headpiece open conformation., Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1., Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit., Our data provide evidence that ADAM23 plays a role in suppression of cancer cell progression through interaction with aVb3 integrin, and suggest that downregulation of ADAM23 in SP cells may contribute toward providing a cancer stem cell phenotype, ITGB3 c.1476G>A mutation decrease the transcription level and affect GPIIIa synthesis and CD61 antigen expression., CD61-overexpressing human umbilical cord mesenchymal stem cell, which had turned into primordial germ-like cells-like cells, could be further differentiated into male germ-like cells., Monomeric fibrin displayed a higher probability of interacting with Integrin alphaIIb beta 3 and a greater binding strength., The frequencies of the rare alleles of CCR2, ITGB3, and 3'UTR of c-fms in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH is more frequent,
OFFICIAL_GENE_SYMBOL ITGB3,
OMIM_DISEASE Bleeding disorder, platelet-type, 16, autosomal dominant, Glanzmann thrombasthenia, Myocardial infarction, susceptibility to, Purpura, posttransfusion, Thrombocytopenia, neonatal alloimmune,
SP_COMMENT disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors., function:Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., online information:The Singapore human mutation and polymorphism database, polymorphism:Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP)., polymorphism:Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433 and MO(+) has Ala-433. MO(+) is involved in NAIT., polymorphism:Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has Arg-515 and CA(+)/TU(+) has Gln-515. CA(+) is involved in NAIT., polymorphism:Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59., polymorphism:Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has Arg-662 and SR(A)(+) has Cys-662., PTM:Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subunit:Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat., tissue specificity:Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.,
matrix metallopeptidase 2(MMP2) matrix metallopeptidase 2(MMP2) Related Genes Homo sapiens
CHROMOSOME 16,
CYTOBAND 16q13-q21,
ENSEMBL_GENE_ID ENSG00000087245,
GENERIF_SUMMARY involvement of MMPs in microinvasive carcinomas, non-steroidal anti-inflammatory drugs suppress MMP-2 expression via repression of transcription, Activated matrix metalloproteinase-2--a potential marker of prognosis for epithelial ovarian cancer., results indicate that two kinds of pro-form and active-form matrix metalloproteinases, MMP-2 and MMP-9, and their degradation products, are present in human seminal plasma, 17beta-estradiol had no influence on production in MG-63 cells or human osteoblast cultures, Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts., design, synthesis and characterization of potent slow-binding inhibitors, repression of expression by ATF3, in differentiating trophoblasts Nitric Oxide regulates the induction of MMP-2 and MMP-9 required for invasion during embryo implantation, shed as membrane vesicle associated components by endothelial cells and this may be a mechanism for regulating focalized proteolytic activity vital to invasive and morphogenic events during angiogenesis, Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas, in pancreatic cancer, invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion., MMP-2 expression seemed to have an important role to play in the epithelial differentiation of tumour cells in synovial sarcoma., SB203580, a p38 MAP kinase inhibitor, reduces MMP-2 expression in melanoma cell line MeWO., increasing expression and endometrial carcinoma appear closely related, A study of the col-1 module of MMP2; structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains., Levels of MMP2 mRNA were reduced in two neuroblastoma clones treated with 300 nM PAF, which was accompanied by an inhibition of invasiveness through Matrigel and by a promotion of differentiation., activation by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species, activation associated with malignant lung cell phenotype; correlation between low hemoglobin level and T/N ratio of MMP-2 may indicate indicate significance of MMP-2 for angiogenesis, Significantly increased activity of MMP-2 was recognized in tumors showing tenascin-C degradation., expression level of MMP-2 mRNA may regulate with invasion ability of cervical cancer, Increased gelatinase activity in Systemic Sclerosis fibroblasts seems to be regulated at translational and/or post-translational level., Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients., destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells., N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells, MMP2 inhibition by NSAIDs via suppression of the ERK/Sp1-mediated transcription., Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism., Coexpression of glucose transporter 1 and matrix metalloproteinase-2 in human cancers, role in A549 cell migration on laminin-10/11, solution structure of a catalytic domain of MMP-2 complexed with a hydroxamic acid inhibitor (SC-74020), determined by three-dimensional heteronuclear NMR spectroscopy, data indicate the involvement of matrix metalloproteinase 2 and matrix metalloproteinase 9 in the cervical ripening process, calcium regulates MMP2 activation in a MT1-MMP-dependent manner in oral squamous cell carcinoma cells, Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2., Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., MMP2 activation is increased by Eph B4 receptor stimulation in human cells, endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women, role of acidic residues in TIMP-2 and TIMP-4 in binding hemopexin C domain, MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD, MMP2 may play a pivotal role in the formation of capillarylike tubular structures in a collagen-containing fibrin matrix in vitro and may be involved in angiogenesis in a fibrinous exudate in vivo., Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates enzyme and cd44 in cox-2-dependent invasion, strong MMP-2 expression correlated with a favorable prognosis of Hodgkin's lymphoma, correlation between expression of MMP-2, TIMP-2 protein and the ratio of MMP-2/TIMP-2 and clinical-pathological parameters of patients with gallbladder carcinoma, The in vitro invasive ability of ovarian tumor cells appeared to be positive correlated to high expression of VEGF and MMP-2., Changes in plasma MMP-2 and TIMP-2 during cardiopulmonary bypass may play an important role in LV remodeling after cardiac surgery., up-regulation of MMP-2 in stromal cells of chronic inflammatory demyelinating polyneuropathy and in vasculitic neuropathies, laminin-5 as a substrate for mTLD, suggesting a role for laminin-5 processing by mTLD in the skin., There are two TIMP binding sites on the hemopexin domain of MMP-2, The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix., Peptide binding results in perturbation of signals from residues located in the gelatin-binding pocket and flexible parts of the molecule., No difference in MMP-2 between RG and SG. Only an increase with time under both conditions., data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein, gelatinase A is inhibited by amyloid precursor protein, specifically in the decapeptide region, matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis, MMP-2 may contribute to eosinophil and mast cell migrations into nasal polyp tissue., Data show that cells grown on oxidized ultra-high molecular weight polyethylene (UHMWPE)discs decreased the release and activity of metalloproteinase 2 (MMP-2) but not MMP-9 compared to cells grown on control and non-oxidized UHMWPE discs., MMP-2 is associated with tumor size, invasiveness and survival in breast cancer., TIMP-2 is significantly increased in cerebrospinal fluid of Alzheimer's and Huntington's disease patients., In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower., MMP2 is regulated by IL-8 in invasive pancreatic cancer, MMP2 is induced by snail protein in squamous cell carcinoma, triple-helical peptides are highly selective substrates for and are hydrolyzed by human MMP2 and MMP9, expression and regulation by intestinal myofibroblasts in inflammatory bowel disease, Gelatinase A is an estrogen-responsive gene and the loss of function polymorphism within an operational estrogen receptor binding site associated with a decrease in genetic fitness underscores the biologic significance of promoter polymorphism analyses., Increased expression of MMP-2 in advanced stage and high grade renal cell carcinoma might be associated with tumor invasion and metastasis, Pathogenic amyloid beta stimulates expression and activation of matrix metalloproteinase-2 (MMP-2); the increase in activation is largely due to increased expression of membrane type-1 (MT1)-MMP. MMP-2 inhibitors increased HCSM cell viability, Exploiting their astrocyte environment, glioma cells activate MMP-2 through the urokinase-type plasminogen activator-plasmin cascade, and this leads to the increased invasiveness of glioma cells in the central nervous system., PR-3 is able to degrade matrigel components and denatured collagen and to directly activate secreted but not membrane-bound pro-MMP-2, Increased in situ mmp-2 activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion, plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by activation of MMP-2, Ultraviolet A downregulates MMP-2 in keratinocytes., The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA, Both active gelatinases were detected in tears of severe corneal ulcer or severe ocular burn cases. The active form of gelatinase expression may be related to the severity of ulceration., differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma, palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours, MMP2 increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells., results suggest that matrix metalloproteinase 2 plays an important role in tumor invasion and metastasis, Increased plasma MMP-2 is associated with colorectal cancer, MMP-2 immunostaining was positive in 4 of 8 cases of invasive carcinoma and stained stromal area around tumor nest. Matrix metalloproteinases are activated in carcinoma in situ and in cervical intraepithelial neoplasia of uterine cervix., findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta, ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from vascular endothelial cells and TNF-alpha mediates the effects of ANG II on MMP-2 release., effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts, Laminin-5 gamma 2 chain and MMP-2 may contribute synergistically to the formation of budding colorectal tumor cells., Increased MMP-2 expression by malignant prostatic epithelia is an independent predictor of decreased prostate cancer disease-free survival., a possible of marker for microangiopathies in children and adolescents with type 1 diabetes., Serum MMP-2 does not relate to the late phase of hepatic ischmeic reperfusion injury after human orthotopic liver transplantation., Tissue from lateral and medial rectus muscles had different levels of expression of TIMP-1 and 2, MMP-2, and BMP-4,which may underlie different characteristics of these extraocular muscles and may influence wound healing after strabismus surgery., one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity., the methionine residue and the Met-turn of MMP2 play an essential role in catalysis or active site structure, data supports a role for MMP-2 in breast cancer progression, both in the growth of primary tumors and in their spread to distant organs, Stromal MMP-2 occurs early and may play a role early in ovarian adenocarcinoma invasion., matrix metalloproteinase-2 has a role in progression of breast carcinoma, MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates, Various growth factors induce migration of human non-small cell lung cancer cells in the presence of extracellular matrix (ECM) components MMP-2 and MMP-9., MMP-2, TIMP-1 and TIMP-2 are downregulated in human orthotopic liver transplantation, downregulated by Cytomegalovirus IL-10 activity in uterine microvascular endothelial cells and differentiating-invading cytotrophoblasts, Matrix metalloproteinase-2 may play a role in the pathogenesis, invasion, and metastasis of cutaneous squamous cell carcinoma., Analysis of promoter MMP-2 gene variability could help us to understand individual susceptibility to MMP inhibitor treatment of the coronary artery disease., In control myometrium only 10% of Gelatinase A (MMP-2)exists in an active form, whereas in uterine leiomyomas, especially in large ones, the values reach 30%, elastin derived peptides following interactions with S-Gal elastin receptor can favor melanoma cells invasion through a three-dimensional type I collagen matrix by upregulating MMP-2 activation., MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential., matrix metalloproteinase 2(MMP-2) was uterine smooth muscle tumor of uncertain malignant potential(STUMP), and in 48% of leiomyosarcoma, MMP-2 correlated negatively with fractional shortening & positively with LV dimension. Changes in the release & activity of MMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with hypertrophic cardiomyopathy., MMP-2 or MMP-9 mediated tumor cell invasion requires integrin cytoplasmic-tail motif EKQKVDLSTDC, although there is a seemingly high structural similarity between TACE and MMP-2, these enzymes are significantly diverse in the electronic and chemical properties within their active sites, Helicobacter pylori infection results in substantially increased in the gastric mucosa, probably contributed to in large part by tissue-resident macrophages, Active involvement of MMP-2 and -9 in end-stage liver disease and orthotopic liver transplantation., results suggest that matrix metalloproteinase-9 and matrix metalloproteinase-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling, Activated protein C (APC) and MMP-2 are coordinately up-regulated and tightly bound in rheumatoid arthritis (RA) synovial fluid and colocalized in synovia. APC may modulate MMP-2 activity in RA., marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women, EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck, endothelial cell-associated cathepsins B and L are not involved in the invasive growth of capillaries from existing blood vessels and the presence of collagen is necessary for MMP2 expression in endothelial cells, a mechanism for ROS function in Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell MMP2 and MMP9 during VCAM-1-dependent lymphocyte migration, Streptococcus pyogenes SpeB activates proMMP-2 with subsequent release of proapoptotic TNF-alpha and sFasL leading to apoptosis, tissue damage and streptococcal invasion in the host., MMP-2 plays a pivotal role in oxLDL-induced activation of the sphingomyelin/ceramide signaling pathway and subsequent smooth muscle cell proliferation., matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 processing and transport in cultured human vascular smooth muscle cells is regulated by serum fetuin, Identified,in the promoter region of the human MMP-2 gene, a cAMP responsive element binding protein (CREB) consensus domain that is highly responsive to IL-10-dependent down-regulation or MMP2 expression in a primary human prostate tumor cells., biochemical analysis of in-tandem fibronectin type II repeats from human matrix metalloproteinase 2, Brg-1 plays a role in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter., data suggest that the MMP-2/TIMP2 system and an activated extrinsic coagulation pathway could cooperate in conditions of elevated SOX and could influence arterial remodeling resulting in the presence of CVD in haemodialysis patients, Overexpression of MMP-2 is associated with non-small cell lung cancer, the hemopexin domain of MT1-MMP is not required for the activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen, Increased gelatinase in culture medium of toxic epidermal necrolysis or Stevens-Johnson syndrome skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for detachment of epidermis in these diseases., MMP-2 status in stromal fibroblasts, not in tumor cells, was a significant prognostic factor associated with angiogenesis in NSCLC., MMP-2 -1306 C-->T polymorphism may be associated with colorectal cancer development and invasion, clearance of pro-matrix metalloproteinase (MMP)-2.tissue inhibitor of MMPs (TIMP-2) complex involves binding to the cell membrane and subsequent low density lipoprotein receptor-related protein (LRP)-dependent internalization and degradation, The Matrix Metalloproteinase-2 was expressed of cultured human uveal melanocytes, and analysis revealed the Matrix Metalloproteinase-2 mRNA., The expression of MMP-2,MMP-9, TIMP-1 and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones., MMP-2 plays an essential role in tumor invasion and metastasis, while TIMP-2 is shown to strongly inhibit cancer invasion and metastasis., Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2, In melanoma cells microtubule-dependent traffic of MMP2/MMP9-containing vesicles and exocytosis are critical steps for invasive behavior., breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes., secreted pro-MMP-2 and pro-MMP-9 are downregulated by farnesyltransferase inhibitors in carcinoma cells, alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix, This study found an up-regulation of TIMP-1, TIMP-2 and MMP-2 RNA in Duchenne Muscular Dystrophy muscle., The correlation between macrophage infiltration and MMP-II supports the role of macrophages in the development of chronic allograft nephropathy., Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression, furin can directly cleave the RXXR amino acid sequence in the propeptide domain of proMMP-2 leading to inactivation of the enzyme., These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2, which is an important proteolytic factor in lung remodeling., MMP-2 is an important determinant of cancer cell behavior but is not inhibited by the collagen binding segment of fibronectin., MMP2 may have a role in cervical cancer recurrence, Hypoxia increased pro-MMP-2 expression, on collagen type I or type IV further via Erk1/2 and p38 MAP kinase signaling for lung fibroblasts, Inactivating mutations in MMP-2 cause Winchester syndrome, a multicentric osteolysis syndrome., up-regulation of Ang2, MMP-2, MT1-MMP, and LN 5 gamma 2 is associated with the invasiveness displayed by human gliomas, High MMP2 expression is associated with breast cancer, E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2, Hypoxia induces an increased invasive capacity via gelatinase up-regulation without loss of cell viability in adenocarcinomas, Age-related MMP-2 upregulation occurs in the human aorta but not in the internal mammary artery., MMP-2 is required for the mitogenic and proinvasive effects of reactive oxygen species on hepatic stellate cells and demonstrate that ERK1/2 and PI3K are the main signals involved MMP-2 expression., expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes., Lysophosphatidic acid and sphingosine 1-phoshpate enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line., Migration of CD4+ T cells is dependent on MMP2 expression; T-helper type 1 (Th1) cells secrete higher levels of MMP2 and have higher migratory capacity in comparison to Th2 cells., expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells, furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque, MMP-2 may play an important role in the development of invasion and metastasis of gastric cancer., COX-2 and MMP-2 may be involved in the airway inflammatory process and contribute to airway remodeling in COPD., MMP-2 was significantly higher in cell extracts from pseudoxanthoma elasticum patients than in control cells, whereas differences were negligible in the culture media., HIV-1 interaction with mannose receptor induces promotion of MMP-2 through mannose receptor-mediated intracellular signaling in astrocytes., Leptin induced human oarticc smooth muscle cell proliferation and MMP-2 expression through a PKC-dependent activation of NAD(P)H oxidase, MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing in giant cell arteritis, melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients., polymorphisms in the gene promoter do not contribute significantly to the interindividual periodontitis susceptibility, hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues; possible role of hemoglobin in joint damage after intra-articular bleeding, generation and modulation of MMP-2 may be directly involved in the different responses seen in knee ligament injuries, MMP-2 seems to be associated with the chronic progressive phase of the multiple sclerosise., The most invasive cell line secreted the highest amounts of MMP-2 and MMP-9., MMP2 immunoreactivity was present in polymyositis and dermatomyositis, There was a significant correlation between active MMP-2 and the invasion and metastasis of epithelial ovarian cancer. Active MMP-2 is a prognostic indicator in patients with epithelial ovarian cancer., MMP-2 may play an important role in the invasion and metastasis of oral squamous cell carcinoma., Pro-MMP-2 levels were higher at early stages of the degenerative disc disease, Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts, The expression of MMP2 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain., monocyte and macrophaage cells in the breast tumor microenvironment play an important role in the modulation of MMP-2., AP-1 Decoy inhibits the increase in MMP-2 activity and the up-regulation of TIMP-1 induced by bleomycin-A5 in pulmonary fibroblasts., MMP-2 may be a marker of microangiopathy, Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-2 is expressed in all of the cysts, FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase, PAF stimulated the gelatinase activity of MMP-2 by activating transcription and MMP-2 expression, MMP-2/-9 activity correlated positively with cardiomyocyte apoptosis. MMPs have pivotal roles in acute cardiac dysfunction during early multiple organ failure in combined vasoconstrictor-masked hypovolemic and endotoxemia shock., Results suggest that MMP-2 might contribute in the pathogenesis of chronic kidney disease., Obese women with polycystic ovary syndrome have elevated serum concentrations of MMP-2., variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity, These findings strongly indicate that increased MMP-2 expression in uterosacral ligaments is associated with pelvic organ prolapse., Active MMP-2 levels are constant during the menstrual cycle., ATP induced phosphorylation of intracellular JNK, and inhibition of the JNK pathway blocked ATP-stimulated MMP-2 release, indicating signaling via this pathway., MMP2 activity in human endothelial cells exposed to high glucose is inhibited by acetylsalicylic acid, These results suggest the activation of proMMP-2 as an important event in the process of uveal melanoma progression., Both MAPKAPK2 and HSP27 are necessary for TGFbeta-mediated increases in MMP-2 and cell invasion in human prostate cancer., MMP-9 and MMP-2 are mediators of inflammation in chronic otitis media with effusion, TGF-beta1 increases in vitro airway wound repair via MMP-2 upregulationin respiratory epithelial wound repair., Results of this study provide evidence that MMP-2 immunoreactive protein is prognostic in estimation of the aggressive clinical course of head and neck squamous cell carcinoma., The colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity., results strongly suggest that Src induces MMP-2 expression via transcription activation and the ERK/Sp1 signaling pathway is involved in this process, variations in the MMP2 gene do not contribute to the development of abdominal aortic aneurysm, MMP-2 expression was increased in posterior wall of thoracic aortic aneurysms., association between oxidative stress and the MMPs/TIMPs system in hemodialysis patients could represent one of the mechanisms involved in the progression of atherosclerosis in this population, PDK1 mediates mammary epithelial cell growth and invasion in part by MT1-MMP induction, which in turn activates MMP-2 and modulates the ECM proteins decorin and collagen, p16 attenuates Sp1 binding to the MMP-2 promoter to suppress gene transcription and overexpression of Sp1 may counteract p16-induced downregulation of MMP-2., potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-2 was reduced in women with menorrhagia, Higher MMP2 activity is associated with breast cancer, chitooligosaccharides may play an important role in the prevention and treatment of MMP-2 mediated several health problems such as metastasis and wrinkle formation, Basal secretion levels of active matrix metalloproteinase-2 respond to various extracellular matrix proteins, cytokines, and growth factors in normal human melanocyte cells and melanoma cell lines from different stages of neoplastic progression., MMP-2 expression has significant correlation with tumor invasion, tumor differentiation and lymph node metastases; MMP-2 may participate in the development of lymph node micrometastasis of gastric carcinoma, Up-regulation of MMP-2 expression was observed in atypical and anaplastic meningiomas., an imbalance between the MMP-2 and TIMP-2, caused primarily by an increase in TIMP-2 activity, contributes to the pathogenesis of diabetic nephropathy., Increase in serum levels eight days after IVIG treatment in neuromuscular disease., When all three proteases are studied in combination, a tendency was found for tumors with high MMP-2, high MMP-14 and low TIMP-2 expression to predict a poor prognosis but the results did not reach significance, In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated., MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors., These results indicate a temporal relationship between MMP-2 production by endothelial cells and the onset of angiogenic event., plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism, overexpression of matrix metallopeptidase 2 and mutant p53 is associated with hydatidiform mole, Two androgen response elements are shown to be responsesible for androgen-induced MMP-2 expression in prostate cancer cells., Inhibition of MMP-2 in transgenic mice may offer an additional approach for treatment of chronic kidney diseases., Results demonstrated higher expression of MMP-2 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences., gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation, Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis., All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II., A pathogenic role for MMP-2 is sugggested for MMP-2 in the alteration of the extracellular matrix of cerebral arteries during aneurysm formation., TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis., Valproic acid causes a change in acetylation of this gene., Data show that MMP2 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family., No convincing evidence was found to support the association of MMP2 SNPs with increased breast cancer risk or survival., Astrocytes surrounding amyloid plaques show enhanced expression of MMP-2 in aged amyloid precursor protein (APP)/presenilin 1 transgenic mice., The expression of MMP-2 and MT1-MMP in atrophic oral lichen planus was significantly higher than in non-atrophic OLP., The effects of turbinatocoumarin and several chalcones from D. turbinata on MMP2 secretion by U87 tumor cells is reported., MMP2 was mainly localized in a concentric layer of the ovarian stroma., novel mode of proMMP-2 activation mediated by serglycin-dependent mast cells serine proteases, This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression., MMP-2 action negatively affects the neutrophils' migration across type IV coated membranes., We conclude that ischemic colitis induces increased activity and expression of MMP-9 and MMP-2 in the involved colonic mucosa., The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1-dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke-related emphysema., High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases., nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins, identifies Src and MMP-2 as potential therapeutic targets in human herpesvirus 8 associated Kaposi Sarcoma and idiopathic pulmonary arterial hypertension, in vitro findings suggest that the environment within the airways of patients with asthma enhances MMP-2 and -14 protein and activity by a complex interaction of transcriptional and posttranscriptional mechanisms, which may contribute to ASM migration., beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed, Results describe the opposite effects of high glucose on matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human endothelial cells., Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis., the -735C/T MMP-2 polymorphism might be an independent prognostic marker in non-small cell lung cancers, Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis., The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells., Parotid saliva of infantile chronic recurrent parotitis patients showed an increased protein concentration, altered mode of protein diffusion, Infliximab treatment increases MMP-2 in serum of patients with CD, the latter also in the intestine, which extends and confirms our previous ex vivo explants observations., This study demonstrates that ATF2 mediates the TGF-beta-induced MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-beta., Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c., MMP2 may have a possible role in the determination of arterial function; has potential implications for involvement in the pathophysiology of cardiovascular diseases., The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported., Upregulation of matrix metalloproteinase-2 (MMP-2) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees., LPA had no effects on membrane type 1-MMP or tissue inhibitor of metalloproteinase-2 expression, but up-regulated MMP-2 levels, contributing to the induction of MMP-2 activation., Plasma levels are increaed diabetic patients which may reflect abnormal extracellular matrix metabolism., Elevated activities of MMP-2 in the non-tumorous lung tissues of curatively resected stage I NSCLC patients are associated with tumor recurrence, We conclude that induction of MMP1 participates in cell invasion and also plays an important role in HIF-1alpha-induced activation of MMP2., mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics. Positive correlation was found between hepatosplenomegaly and the MMP-2/TIMP-1 and MMP-2/TIMP-2 ratios and between CNS involvement and the MMP-2/TIMP-2 ratio, MMP-2 probably plays an important role in the carcinogenesis and progression of laryngeal squamous cell carcinoma., No significant variation in MMP2 was present in the diabetic group or in patients with acute coronary disease syndrome., We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite., The results indicate that TIMP-2 and MMP-2, Epithelial MMP-2 expression is associated with pancreatic cancer, may degrade fibrillin-2 and may play a role in the remodeling of elastic system fibers in the periodontal ligament, Results showed that the endogenous matrix metalloproteinase-2 might be involved in skin development and in maintenance of cutaneous structure and function., epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis, MMP-2 is modulated by phosphorylation on multiple sites in a tumor cell line and protein kinase C may be a regulator of this protease in vivo., Expression of active MMP-2 was increased in 9L/F344 rat brain during the growth of malignant gliomas at different time intervals, which indicate that 9L/F344 animal model may be a prospective animal model to test new MMPs inhibitors., gene polymorphisms for MMP-2 did not show any association with the G-AgP in Chinese subjects with generalized aggressive periodontitis, AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP2., Transendothelial migration of mesenchymal stem cells is at least partially regulated by MMP-2., Activated MMP-2 and MMP-9 were detected in eight out of nine cases of floppy valves., Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response., These experiments identified a collagen-binding domain (CBD)-binding site on type I collagen and demonstrated that a corresponding synthetic peptide can inhibit hydrolysis of type I and IV collagens by competing CBD-mediated gelatin binding to MMP-2., proMMP-2 and proMMP-9 secretion are decreased in THP-1 cells infected with Toxoplasma gondii, Bcl-2 induces the expression of MMP2 in renal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro., stromal fibroblasts play a role in promoting pancreatic cancer metastasis via activation of the uPA-plasminogen-MMP-2 cascade, Our results suggest that the presence of -1575G allele in the MMP-2 promoter region may be of significance in the assessment of colorectal cancer risk and invasive potential., describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes, Matrix metalloproteinase 2 gene analysis was negative for mutation in the three patients., Expression of MMP2 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissie., results suggest that MMP2 is a more sensitive predictor than MMP9 of lung cancer progression, metastasis, and survival, positive correlation between the expressions of CD147, MMP-2 in human gliomas and the degree of malignancy and prognosis, genetic polymorphisms or haplotype in the MMP2 promoter may play a role in mediating the susceptibility to nasopharyngeal carcinoma in Chinese populations, MMP-2 activity was enhanced in pleural effusions from patients with benign diseases compared with cancer patients., Results determine the level of MMP-2, its natural inhibitor TIMP-2, their ratio and HER-2/neu as diagnostic and prognostic factors in breast cancer., Binding of two zinc and two calcium ions to the MMP-2 catalytic domain is energetically favored., syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis, COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness., MMP-2 expression in surface epithelium basal cells of vocal fold polyps showed enhancement compared with normal vocal folds., ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer, MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow., Arsenic trioxide may down-regulate the expression of VEGF and inhibit the activity of MMP-2 and 9., The data provide evidence supporting a potential role for the endothelial production of MMPs in promoting cancer cell extravasation., TIMP-1 and its inhibitory domain, N-TIMP-1, are weak inhibitors of MMP2., 6Mercaptopurine decreased HSP27 nucleous expression that was associated with inhibited MMP2 activity and NO production., NGF stimulates endothelial cell invasion and cord formation by augmenting MMP-2 via the PI3K/Akt signaling pathway and AP-2 transcription factor, which may be responsible for triggering angiogenesis., VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women, These findings suggest that MMP-2 -1306C/T polymorphism may be a genetic risk factor related to lumbar disc disease susceptibility in the young adult population., fibroblast growth factor 2 release from the lens capsule by MMP-2 is essential to lens epithelial cell viability and survival, P-gp substrate drugs can greatly upregulate the expression of CD147 and MMP2 and 9 in multidrug resistant breast cancer cells, therefore enhancing the tumor metastatic capability., MMP-9, but not TIMP-1 nor MMP-2 expression is increased in plaques causing acute coronary syndrome., MMPs also cleave a variety of non-ECM proteins, including cytokines, chemokines, and growth factors, activating or inactivating them, or generating other products that have biological consequences., Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of MMP2., Increased mmp-2 is assopciated with squamous cell laryngeal carcinoma, an interaction between chitosan and matrix metalloprotease 2 decreases the invasive activity of human melanoma cells, The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC, ROCK-II is a critical mediator of colon cancer cell invasion through its modulation of MMP-2 and -13 at the site of invadopodia but regulates proliferation in non-malignant intestinal cells., Nicorandil suppresses the increases in MMP2 and MMP9 levels and activities and prevents the development of ventricular remodeling in acute myocardial infarct, MMP-2, MT1-MMP and TIMP-2 mRNA expression levels were correlated with clinical stages and histological subtypes of thymic epithelial tumours. The activation of pro-MMP-2 might be mediated by MT1-MMP and TIMP-2 up-regulation., direct CpG-oligodeoxynucleotides and TLR-9 interactions in HT-29 cells could provide new approaches in malignant tumor therapeutic strategies, MMP-2 processing of HARP and CTGF released vascular endothelial growth factor (VEGF) from angiogenic inhibitory complexes., SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level., MMP-2 may be implicated in pathogenesis of leiomyoma., serum MMP-2 levels in Behcets patients with vascular involvement showed a positive correlation between Leeds activity score, Mmp2 and Mmp9 gelatinase activity, and caspase3 immunoreactivity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice., This study does not provide strong evidence for further investigation into the role of the MMP2 and MMP3 variants in melanoma progression, MMP2 expression varied with histological type in epithelial ovarian cancers. It was associated with better prognosis. In stromal cells, its expression was correlated with hyaluronan expression., The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma, MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2, One single irradiation of UVB increases the immunohistochemical expression of gelatinases in almost all evaluated cell lines, with the exception of MMP-9 in keratinocytes, MMP-2 upregulation confers on tumor cells the ability to degrade the subepithelial basement membrane and subsequently invade the cervix., Patients with larger aortic diameters have increased MMP-2/TIMP-1. Modifying MMP expression may have a role in development of aneurysms., exposure of human melanoma cells to hyaluronan fragments leads to nuclear factor kB (NFk-B) activation followed by enhanced expression of matrix metalloprotease (MMP) 2 and interleukin (IL)-8, factors that can contribute to melanoma progression., polymorphisms in MMP1, MMP2, MMP3, MMP9, or MMP10 weren't associated with acute MI compared with angina or with coronary disease. Circulating levels of MMP2 are independently associated with development of an acute MI rather than stable angina., EMMPRIN and MMP-2 are the major determinants of malignancy in cancers, N-acetylcysteine prevented LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts., MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression., MMP2, MMP14, and MMP9 might be used as prognostic markers in patients with sinonasal and oral malignant melanoma., These results suggest that P. acnes stimulates hDF to produce TNF-alpha, which mediates the expression of proMMP-2 through the NF-kappaB pathway., 735C/T polymorphism not related to generalized aggressive periodontitis, The expression of MMP-2 in supraglottic carcinoma was significantly higher than that in normal laryngeal mucosa., Chorionic gonadotropin promotes trophoblast invasion and migration through activation of ERK and AKT signaling involving their downstream effector MMP-2., The activity of MMP-2 in the patients with positive tenascin-C degradation was also found to be significantly higher than that in the patients without., The aim of this study was to analyse the influence of recombinant IFN beta-1a (identical with natural IFN-beta) on MMP-2 and MMP-9 activities, A high incidence of MMP-2 expression is confirmed in erythroblasts from acute myeloid leukemia (AML) patients and suggests the possible involvement of MMP-2 in the invasive phenotype of AML., platelet activation and aggregation is regulated by MMP-2 that specifically interacts with integrin alpha(IIb)beta(3), Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis., data suggest that MMP-2 -735C/T, MMP-9 -1562C/T and MMP-12 357Asn/Ser polymorphisms are not associated with susceptibility to severe CP in Turkish population. T allele of MMP-9 -1562 gene might be associated with decreased susceptibility to severe CP., Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased MMP2levels., In carotid stenosis MMP-2 levels tended to increase 30 days after carotid endarterectomy., The expression level of Matrix Metalloproteinase 2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes' stage in colon cancer tissues., These findings suggest that MMP2 promoter polymorphisms may provide some predictive value for hepatocellular carcinoma recurrence after liver transplantation., Report association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women., We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription., Markedly increased levels of serum MMP-2 in infectious, especially bacterial, meningitis may reflect the degree of damage to the blood-brain barrier., MMP-2 could be acknowledged as a new prognostic factor in melanoma., IR/visible light spectrum of sunlight significantly decreased skin MMP-2 expression., The MMP2 rs243865-T allele is not a major rheumatoid arthritis genetic factor in this population., These results suggest that MMP-2 overexpression by cancer cells in peritoneal implants and not in the primary ovarian cancer is predictive of ovarian cancer prognosis and more likely reflects the presence of particularly aggressive clones of cancer cells., MMP-2 -1306C-->T polymorphism contributes to the development of squamous cell cervical cancer in the population studied, especially in women who had first coitus at an early age., Data show that enhanced expression of matrix metalloproteinases 2 was detected in colorectal cancer patients with distant metastases., MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B, Performed molecular docking simulations to study binding at the S1' pocket in the apo form of MMP2, and identify, at the molecular level, the structural properties relevant for the designing of specific inhibitor of MMP-2., results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs., High numbers of human skin cancers express MMP2 and several integrin genes., polymorphisms in the MMP2 is associated with the protective effect of helicobacter pylori on esophageal adenocarcinoma risk, Crucial participants in tumour invasion and metastases are matrix metalloproteinases, tissue inhibitor of metalloproteinase inhibitors and cellular adhesion molecules. They play roles in tumour invasion and metastasis in non-small-cell lung carcinomas., MMP-2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer., Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling., These results indicate an association of MMP-2 -1306C/T polymorphism with the risk of adenomyosis, suggesting a potential role in adenomyosis development in North Chinese women., HCG increases the secretion of MMP-2 and -9 in cytotrophoblasts in a dose-dependent manner., The dysregulated MMP2 expression is associated with infertility and early pregnancy loss., Adenoviral-mediated transfer of RNA interference against MMP-2 results in the retention of neurological function and significantly inhibited tumor growth., Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis., MMP-9, but not MMP-2, may have a role in mechanisms for stimulation of cell division and matrix biosynthesis, which cause matrix remodeling in the umbilical cord of preeclamptic newborns, Report the production of vascular endothelial growth factor and MMP-1/2 via protease-activated receptor in human endometrial stromal cells., This study suggests that MMP14 is involved mostly in prostate cancer implantation and that MMP2 and TIMP2 expression by reactive stromal cells might be used as predictors of diease-free survival in T3N0-2M0 Pca., Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer., the activity of MMP-2 in the internal mammary artery is correlated with age, hypertension, diabetes and estimated glomerular filtration rate., Knockdown of MMP-2 did not significantly alter the metastatic potential of the liver cancer cells but lead to a marked inhibition of metastatic foci growth., MMP-2 expressed by metastatic ovarian cancer cells functionally regulates their attachment to peritoneal surfaces, In this study we found the MMP2 rs2287074 A allele may be associated with a lower likelihood of age-related maculopathy in older Caucasian women, particularly those who have never used hormone therapy., MMP-2 is valuable in determining the patients with more aggressive form of non-small cell lung cancer.., Stromal expression of MMP-2 (matrix metalloproteinase-2) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps, Alcohol reduces MMP-2 plasma activity in healthy humans and in isolated vascular smooth muscle cells., The study suggested that the C/C genotype of the C-735T SNP in the promoter region of MMP-2 gene may be a potential risk factor for epithelial ovarian cancer, but the C-1306T SNP may have no association with the risk of epithelial ovarian cancer., in colorectal neoplasms, MMP-2 expression correlates with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlate with venous invasion, Expression of MMP-2 does not distinctly correlate with the proliferation of endothelial cells, but plays a very important role in affecting endothelial cell migration, invasion and angiogenesis., soluble EMMPRIN probably triggers the promotion of cancer invasion in vivo, MMP-2 inhibition induced apoptotic cell death in vitro, and suppressed tumor growth of preestablished U-251 intracranial xenografts in nude mice, These results suggest an important role for MMP-2 and MMP-9 in the induction of T. cruzi-induced acute myocarditis., regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH., key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Berberine induced down-regulation of MMP2 in gastric neoplastic cells in vitro., MMP-2 overproduction is associated with bone marrow stromal cells in multiple myeloma, In prostate adenocarcinoma distant spread is more likely to occur in patients with high levels of VCAM and low levels of MMP-2., Higher net MMP-9 (but not MMP-2) activity in gestational hypertension., Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs, MMP-2 stimulates keratinocyte survival whereas MMP-9 promotes terminal differentiation., High epithelial MMP-2 expression in gastric cancer is associated with poor survival., MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not., The C allele of MMP-2 -1306C/T polymorphism did not modify the risk of developing endometriosis but significantly increase the risk of developing adenomyosis., Neither MMP-2 SNPs nor MMP-9 SNPs revealed significant association with proliferative diabetic retinopathy in single-locus comparisons., Demonstrate an association of the MMP-2 gene with the development of lacunar stroke, and no association of MMP-2 with other stroke subtypes., The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry., Significantly higher expression of MMP-2 in melanoma-associated spongiform scleropathy(MASS), indicating MMP-2 is involved in development of MASS and is produced by scleral fibroblasts under influence of tumor cells and/or tumor-infiltrating macrophages., megsin indirectly links to MMP2 activation via the inhibition of plasmin enzymatic activity, SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3., The expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in a verrucous proliferative leukoplakia sample, was investigated., Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium., The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients., proMMP-2 activation involves MT1-MMP dimerization, PKC inhibitors blocked phagocytosis by retinal pigment epithelial (RPE)cells. Human RPE-cell line showed reduced secretion of MMP-2, although MMP-9 secretion by PKC activation was conserved in both cell types., Data suggest that KiSS-1 suppresses the motility and invasive ability of renal cell carcinoma cells which possess hOT7T175 with either a negative expression or very low expression level of KiSS-1 through, at least in part, the down-regulation of MMP-2., In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9., There was significant correlation between immunohistochemical staining for MMP-2 & clinical condition of medullary thyroid carcinoma patients & correlation between state of apparent cure compared to persistence of MTC after thyroid surgery., Results describe the relationship between protein expression of VEGF-C, MMP-2 and lymph node metastasis in papillary thyroid cancer., Dengue Virus-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection., Plasma levels of MMP-2 and MMP-9 are increased in obese patients which may reflect abnormal extracellular matrix metabolism., Increased MMP-2 expression is associated with differentiated thyroid carcinoma., Pathologic findings demonstrated that the intensity of MMP2 staining in cancerous tissues was associated significantly with histological types, distant metastasis, and Nevin stages of gallbladder carcinomas., MMP2 transcription activity is significantly upregulated along with neuron and glial cell apoptosis following spinal cord injury in transgenic mice., Curcumin can suppress Tca8113 invasion and migration by reducing the activities of MMP-2 and MMP-9., Formation of adenomyosis does not result from altered invasiveness of endometrial stromal cells, but may result in elevation of MMP-2 and TIMP-1., serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in chronic kidney disease patients, Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2., The MMP2 gene does not play a crucial role in conferring risk for nasal polyps in a Taiwanese population., Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear, This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor., a link between RhoA, JNK, c-Jun, and MMP2 activity that is functionally involved in the reduction in osteosarcoma cell invasion by the statin. This suggests a novel strategy targeting RhoA-JNK-c-Jun signaling to reduce osteosarcoma cell tumorigenesis., 3,4,5-trihydroxybenzaldehyde from Geum japonicum has inhibition effect on MMP-2 and MMP-9 activities in smooth muscle cells, The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues., Low circulating levels of ProMMP-2 are associated with bladder cancer., Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM., Our findings suggest an important, previously unrecognized role for MMP-2 during myelination in the peripheral nervous system., MMP-2 activity is associated with treatment failure in childhood acute lymphoblastic leukemia, Estrogen and progeterone upregulate MT1-MMP/MMP-2 and alter cell migration in vascular smooth cells., This study suggest that carriage of the (-1575G/A, -1306C/T) allele may influence the MS disease process through MMP-2 serum level production., Significantly higher matrix metallopeptidase 2 expression is associated with prostate cancer., Level of plasma MMP-9 and MMP-9, increased plasma activity of MMP-2 in women with metabolic syndrome is important because they fit in with an early stage of cardiovascular disease, Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression., COX-2 and MMP-2 expression was increased in nasopharyngeal carcinoma, and was positively correlated with lymph node metastasis., The structural changes in the venous wall in addition to the increased expression of MMP-2, MMP-9 and MMP-13 in venous aneurysms suggests a possible causal role for these MMPs in their pathogenesis., H(2)O(2) induced cell death and fibronectin mRNA expression, but decreased the amount of MMP-2 mRNA., results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2, The data indicates that the decidual microenvironment may exert the key control for trophoblast cell invasion mainly through influencing MMP-2 expression., Serous and mucinous ovarian tumors express different profiles of MMP-2., RECK is cleaved by MMP-2 and MMP-7 and competitively inhibits MMP-7-catalyzed cleavage of fibronectin, uterine decidua possesses protease activity in situ and in vitro and uterine natural killer cells are a major source of MMP-2 and TIMP-2, The positive expression of MMP-2 can be used to estimate the metastatic potential of cervical squamous carcinoma., MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis can be markers of acute rejection after liver transplantation., Platelet-derived microparticles promote prostate tumor invasiveness, at least in part by stimulation of MMP-2 production, Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis, On the basis of linked-function analysis, we demonstrated that collagen binding domain of MMP2 tuned the cleavage of collagen IV by MMP9, presumably by inducing a ligand-linked structural change on the type IV collagen., The role of MMP-2 and the signaling pathway involved in EGF-promoted invasion by human pancreatic cancer cells PANC-1 was investigated., In prostate cancer patients with tumors of a higher stage (pT3), a polymorphic allele in the MMP2 gene was more frequent than in patients with lower tumor stage, metastasis and survival of patients with bladder are mediated, at least in part, by matrix metalloproteinase-2, role in the pathogenesis of inguinal hernia, Porphyromonas gingivalis could induce human gingival fibroblasts to over-express MMP1 and MMP2, and fimA genotypes of Pg may be related to this pathogenicity., The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis., MMP-2 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls., Results describe the levels of matrix metalloproteinases 2 and 9 in human scar tissue., Data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway., Mechanisms other than COX-2 and MMP-2 may contribute to the promotion of angiogenesis in patients with adenomyosis or endometrial polyps, Data show that dominant-negative transforming growth factor beta type II receptor decreases matrix metalloproteinase 2 in hepatic stellate cells, and upregulates SKI-like oncogene, which antagonizes TGF-beta signaling., Expression of MMP-2 in esophageal squamous cell carcinomas was higher than in eophageal epithelium, and higher in the advanced stage; MMP-2 plays an important role in tumor invasion and metastasis of ESCCs., Increased PRL1 expression results in activation of Src and ERK1/2, which stimulates MMP2 and MMP9 production, leading to increased cell migration and invasion., Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., The proteolytically active matrix-metalloproteinase (MMP)-2 is upregulated and as an early regulator of ovarian cancer metastasis., TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in Renal clear cell carcinoma patients., As(2)O(3) inhibits expressions of COX-2, MMP-2 and MMP-9 in K562 and SGC7901 cells., selective COX-2 inhibition suppresses the invasion activity of OSCC cells via down-regulation of an MMP-2-activating mechanism involving TIMP-2 and production of the MMP-2 protein by an interaction between cancer cells and stromal fibroblasts, Results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas., Activated protein C resulted in MMP-13 activation in cartilage cultures, and it was associated with increased MMP-2 and MMP-9 activity., Enhanced expressions of MMP-2 and -9, VEGF, and increased microvessel density in endometrial hyperplasia may play important roles in the pathogenesis of women with anovulatory dysfunctional uterine bleeding., The RNA interference approach towards MMP-2 may be an effective therapeutic strategy for the clinical management of pancreatic tumors., Results describe the effect of histamine on cell adhesion and expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 in human tumorigenic and non-tumorigenic mammary cell lines., Tiotropium bromide suppressed MMP2 production by cultured lung fibroblasts., Low Levels of MMP-2 due to epigenetic silencing is associated with invasiveness in cancer., Tn-C deposition into the extracellular matrix requires participation of active MMP-2 and stromal fibroblasts, Evaluated MMP-2 and -9, along with their inhibitors TIMP-1 and -2, in pre-eclamptic women compared with normotensive pregnancy and non-pregnant women.Results confirm that MMP-2 and TIMP-1 values are significantly higher in preeclampsia., MMP-2 polymorphisms are associated with systolic heart failure risk in Han Chinese, Tissue transglutaminase-2 and matrix metalloproteinase-2 expression are significantly correlated in vivo, in peritoneal xenografts and in human ovarian tumors., MMPs play an important role in carcinogenesis of biliary cancers, Combined hyperlipidemic patients have increased levels of prothrombotic and microinflammatory parameters and higher levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 than control subjects., MMP-2 rs17859821 A allele was associated with better prognosis of systolic heart failure in the northern Han Chinese population., Statin therapy did not alter serum MMP-2 in patients with abdominal aortic aneurysms., these results suggest that Ang II mediates an increase in MMP 2 activity in macrovascular endothelial cells through signal transduction pathways dependent on PI3K and Src-family tyrosine kinases activation, as well as JNK and FAK phosphorylation., MMP-1 and MMP-2 are major factors involved in the invasion of endometrium into the peritoneum and in vascularization of endometriosis., Obese children and adolescents had higher circulating MMP-8 concentrations, lower plasma TIMP-1 concentrations, and higher MMP-8/TIMP-1 ratios than non obese controls., promoter gene polymorphism is associated with psoriasis, Studies do not support a role for BSP in promoting metastasis through interactions with pro-MMP-2., Our study revealed increased immunoexpression of MMP-2, MMP-9 and TIMP-2 in acute cellular rejection of renal allografts, found increased MMP-2 expression in cells lacking TSC1/TSC2 compared with their respective controls, Progesterone reduces PR and SP4 binding to the MMP-2 promoter, thereby suppressing transcription, These results together indicate that MMP-2 activity can be promoted in keloid fibroblasts between collagen bundles, matrix metalloproteinase-2 expression in stromal cells can be a high-risk indicator for recurrence in patients with stage II colon cancer, Expression of MMP2 in RCC cells was suppressed by Ror2 knockdown, placing Ror2 as a mediator of MMP2 regulation in RCC and a potential regulator of extracellular matrix remodeling., Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2., these findings support a role for MMP-2 genetic variation in breast cancer susceptibility., Key collagen binding site residues in the three fibronectin type II-like modules of MMP-2 have been localized and functionally confirmed by nuclear magnetic resonance mapping., Patients with coronary heart disease showed increased levels of MMP2 and MMP9., MMP2 expression higher in scar tissue than control, The staining intensity score of E-cadherin=3, matrix a metalloproteinase-7<1, and matrix metalloproteinase-9>or=2 can be used as the diagnostic criteria for hepatocellular adenoma, Protein expression levels of lipocalin-2 are upregulated in visceral adipose tissue of obese subjects along with increased activity of matrix metalloproteinase-2 and matrix metalloproteinase-9/ lipocalin-2 complex., LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, curcumin has anti-metastatic potential resulting in inhibition of MMP-2 and -9 in human lung cancer A549 cells., The expression of MMP-2 and MMP-9 were closely related with destruction of the ossicular chain in cholesteatoma., The MMP-2 polymorphism was significantly associated with protection against lung cancer., MMP2 -1360C>T and +649C>T variants are not risk factors for abdominal aortic aneurysms., we found no significant differences of CSF, serum or skin concentrations of MMP-2 in amyotrophic lateral sclerosis (ALS) patients as compared to controls, suggesting it is not the link between ALS neuronal degeneration and skin alterations, hypoxia reduces MMP-2 activation and subsequent invasion of human cardiac myofibroblasts by reducing membrane expression of MT1-MMP and may delay healing after myocardial infarction, FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for oral cavity squamous cell carcinoma treatment., MMP2 was found in epidermal and dermal ests of maligant cells and in atypical melanocytes along the hair follicles in lentigo maligna melanoma, indicating its involvement in tumor invasion., High expression of matrix metalloproteinase-2 was less significant for the invasive potential and prognosis of colorectal tumors., Data show there was a significant correlation between the level of TGF-[beta]1 and the levels of MMP-2 and TIMP-2 immunostainings in pancreatic ductal epithelium., The migration of bone marrow (BM) mesenchymal stromal cells was the result of the variable level of MMP/TIMP in response to inflammatory stimuli., Higher active MMP-2 is associated with colorectal cancer., Data show that mortality was significantly associated with adiponectin, resistin, PIIINP, MMP-2, TIMP-1, and serum creatinine., Functional polymorphisms in matrix metalloproteinases might play roles in developing esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high incidence region of North China., High matrix metallopeptidase 2 is associated with breast cancer., Data suggest an involvement of matrix metalloproteinases 2 and 9 in pseudoxanthoma elasticum pathology., Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion., Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin., Factor Xa and thrombin regulate MMP-2 enzymatic activity through its activation and degradation., Plasma Hg concentration is positively associated with both pro-MMP-9/TIMP-1 and pro-MMP-2/TIMP-2., High expression of MMP-2 is associated with malignant and invasive skin squamous cell carcinoma growth., Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease., Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., Up-regulation of MMP-2 and MMP-9 is one of the mechanisms by which Skp2 promotes lung cancer cell invasion., approximate 40% of plasma specimens from healthy individuals had detectable levels of the MMP-2, SNPs in MMP1, MMP2, MMP7 and MMP12 have roles in response to chemotherapy in lung cancer, We report two siblings affected with a novel mutation in matrix metalloproteinase 2 gene and discuss their clinical and radiographic findings., IL-1beta increased MMP-2 activity and transcription of human cardiac fibroblasts via iNOS-NO pathway., Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4., strong correlation between MMP-2 activation and elastic fiber disorganization, stiffness, calcification, and vasomotor dysfunction in the arterial vasculature in dialyzed chronic kidney disease patients, Higher amniotic fluid MMP-2 and TIMP-2 levels are found in women who eventually develop preeclampsia., present study showed that the MMP-2 -1306CC genotype increased the risk of developing acute myocardial infarction, Of MMP-2/TIMP-2/MMP-14 complex, high expression of MMP-2, TIMP-2 & MMP-14 mRNA may contribute to local invasiveness of ameloblastoma; local invasive capacity of ameloblastoma more likely related to high transcription levels of TIMP-2 and MMP-14, These preliminary data demonstrate the expression of metalloproteinase 2 and 9 proteins in the placentas of uncomplicated pregnancies., Data show that ehe expression level of uPA and MMP-2 was not associated with the grade of CIN lesions., The mRNA expression of MMPs and TIMPs was significantly higher in stroma than in epithelium of salivary gland pleomorphic adenomas., up-regulation of Notch1 expression also reduced the migration of Hep-2 cells, which was closely associated with down-regulation of MMP-2 and MMP-9., RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells., WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2., Orthodontic force regulates levels of secreted MMP2 in periodontal ligament fibroblast cultures., Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases., MMP-2 and MMP-3 are directly linked to Abeta in the brain and a dysfunction may influence the processing of Abeta., Immunoexpression of metalloproteinase-2 does not correlate with recurrence, mortality, relapse-free survival, survival, degree of cell differentiation, or staging of colorectal cancer., expression of MMP-2 and TIMP-1 was found to be higher in lung cancer patients. Finally, we claim that determination of MMP-9 enzyme levels and expression of MMP-2 and -9 and TIMP-1 can be used as a marker in lung cancer., Expression and activity of MMP-2 was enhanced by the IkappaBalpha siRNA in human ciliary muscle cells through the activation of the NF-kappaB signaling pathway., EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway., in the proliferative phase of hemangioma, MMP-2 may promote over-proliferation of endothelial cells, MMP-2 transcriptional regulation by EGF in invasive trophoblasts is mediated through several transcription factors including p53, AP-2alpha and -gamma, C/EBPepsilon and -lambda and SP-1. p53 mediates both basic and EGF-induced MMP-2 transcription., Estradiol inhibits MMP-2 expression via the ER and the MAPK pathway in rat cardiac fibroblasts and in a human fibroblast cell line, Cleaved high molecular weight kininogen inhibits tube forming capacity of endothelial progenitor cells by suppression of MMP-2 activation., evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR, Increased matrix metalloproteinase 2 expression is associated with soft tissue sarcoma., cytokines and inhibitors have an up- or down-regulatory effect on MMP-2 and MMP-9 expression in lung cancer and malignant mesothelioma, Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation., Data show that P-cadherin overexpression in breast cancer cells with wild-type E-cadherin promotes cell invasion, motility, and induces the secretion of MMP-1 and MMP-2, which then lead to P-cadherin ectodomain cleavage., Findings suggest an important role for MMP-2 in transformation mediated by HMGA1 in large-cell, undifferentiated lung carcinoma and support the development of strategies to target this pathway in selected tumors., de-N-acetyl GM3 activates matrix metalloproteinase-2 in melanoma cell lines, High MMP2 is associated with cutaneous malignant melanoma., results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Ets-2 and p53 mediate cAMP- induced trophoblast invasiveness, through regulation of MMP-2., STK15 Phe31Ile and MMP-2 -735C/T polymorphisms might be the genetic susceptibility factors for esophageal cancer in the Mongolian population., ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB, Higher levels of TIMP-2 were found in the gingival crevicular fluid of chronic periodontitis patients compared with controls, and these markers decreased 3 months after periodontal therapy., Low or no RECK expression and increased MMP-2 expression may be associated with negative clinical findings in ameloblastoma, changed level of matrix metalloproteinases, especially that of MMP-2 in serum, may be of value for detection of cardiac involvement in Emery-Dreyfuss muscular dystrophy patients, especially in those patients with no evident subjective cardiac symptoms, a possible relationship between the entity of morphological disorganization of the oral mucosa in different pathologies and the increase of MMP-2 and MMP-9 expression., The expressions of MMP-2 and MMP-9 were positively correlated with CD147 expression in breast cancer., Acute high glucose stimulation down-regulates the expressions of MMP-2 and EMMPRIN at RNA and protein levels in the endothelial cells., Cav1 might regulate MMP2 and MMP9 activity through Erk-activated signal pathway, Galpha12/13 upregulate matrix metalloproteinase-2 via p53 promoting human breast cell invasion., Data demonstrat that two major apoptotic pathways in ECs, caspases and p38 MAPK (p38), differently affect endothelial cell behavior as well as matrix metalloproteinase-2 expression., Data demonstrate that EMMPRIN expression increases in the human left ventricle after acute myocardial infarction (AMI), and that expression of MMP-2 and MMP-9 are correlated with EMMPRIN expression in AMI., Results show that the treatment of THP-1 cells with CRP enhances the expression of MMPs and TIMP-1, 2, and 9 genes significantly, and that this upregulation is attenuated by atorvastatin, Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis., In a large cohort of European Caucasian systemic sclerosis (SSc) patients, MMP2, MMP9, and MMP14 genes are not involved in the genetic background of SSc., Elevated serum activities of MMP-2 and -9 are associated with dramatically increased restenosis rates after PCI with implantation of drug-eluting stents., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9., No relationship was found in Chinese Han patients with hypertensive heart disease between the presence of the MMP-2 -1306C>T and -735C>T polymorphism and atrial fibrillation., HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP-2 promoter., The study shows a novel mechanism for antiproliferative effects of PKD1, a protein of emerging translational interest in several human cancers, through increased production of MMP-2 and MMP-9 in cancer cells., Thrombin enhances the migration of chondrosarcoma cells by increasing MMP-2 and MMP-13 expression through the PAR/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Study confirms an altered MMP2 expression in subjects with chronic C hepatitis and such alterations can contribute to development of liver fibrosis., role of osteopontin (OPN) in prostate cancer PC-3 cells; study demonstrated OPN knockdown could downregulate MMP-2 and MMP-9; IKK-2 may play a crucial role in OPN-induced MMP-2 and MMP-9 expressions via NF-kappaB-mediated signaling pathways, regulates the expression of MMP-2 and MMP-9, which increases the invasion ability of MCF-7 cells through the Ras/MAPK signaling pathway., PTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma. The expression of PTEN and MMP-2 correlates with the malignance and the aggression of thymoma., secretion of MMP-2 proform increased significantly in cells subjected to 4 h of hypoxia followed by 4 or 24 h of reoxygenation., Findings indicate that Twist1 induces HCC invasion via increased activity in MMPs, specifically in MMP2 and MMP9, leading to poor clinical prognoses., Matrix Metalloproteinase-2 gene variants are strongly associated with patient's functional disability at three months after stroke onset., results presented here strongly suggest that MMP-2 interacts with alpha(IIb)beta(3) to regulate the shedding of CD40L exposed on the surfaces of activated human platelets, An impaired MMP2/TIMP2 ratio might be involved in the decreased levels of circulating TRAIL observed after acute myocardial infarct., The substrate degradomes of two closely related matrix metalloproteinases, MMP-2 (gelatinase A) and MMP-9 (gelatinase B), in fibroblast secreted proteins, were compared., Interpretation of differential expression of MMP2 between gastric cancer and normal tissue is difficult to establish., AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis, MMP2 promoter polymorphisms was associated with lower susceptibility to lung cancer, Functional polymorphism in the promoter region of the MMP-2 and MMP-9 genes plays a certain role in the development of acute coronary events., emodin, aloe-emodin and rhein inhibit the protein levels and activities of matrix MMP-2 but not gene expression of MMP-2; they do inhibit gene expression of MMP-9 and migration and invasion of human tongue cancer SCC-4 cells, Matrix metalloproteinase (MMP-9 and MMP-2) gene polymorphisms influence allograft survival in renal transplant recipients., expression of CD147 was positively correlated with matrix metalloproteinase-2, Ki-67 labeling index, or both in invasive pituitary adenomas (P< .01 and P< .01, respectively)., overexpression/downexpression of ZNF580 leads to the enhancement/decrease of MMP2 and VEGF expression as well as the migration and proliferation endothelial cells., Systematic review/meta-analysis suggesting that MMP-2 expression is of poor prognostic significance for survival in patients with non-small cell lung cancer., inhibition of MMP-2 activity (proprotein convertases) activity results in decreased invasiveness of primary human melanoma cells despite their altered p53, CDKN2A and N-Ras genes, Data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway., The four functional SNPs in the MMP1, -2, and -3 promoter regions do not play critical roles in the development of high myopia in the Japanese population, After dsRNA stimulation expression of MMP-2 mRNA did not change in human nasal polyp epithelial cells., Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions., The present article studied the expression of CD147 on neutrophils and its potential role in neutrophil chemotaxis, MMPs production and the invasiveness of fibroblast-like synoviocytes., Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147., Matrix metalloproteinase-2 and -9 contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues., Statistically significant genetic associations of ocular refraction to polymorphisms near MMP1 and within MMP2 were identified in the AMISH but not among the ASHK families., A positive correlation was found between the expressions of HIF-1alpha and MMP-2 in degenerative intervertebral discs., MMP-2 and MMP-9 increased significantly in chronic subdural hematoma as compared with those in subdural effusion., The abnormal expression levels of RECK and MMP-2 may play an important role in carcinogenesis of esophageal squamous carcinoma., Data show that gene expression rates of MMP-2 and TIMP-1 were higher in ONFH biopsies whereas TIMP-2 and MMP-9 gene expression was not significantly altered., MMP-2 activity is decreased in the urine of patients with benign prostate hyperplasia compared to cancer., TGF-beta, leading the tissue invasion mediated by MMP-2, is a strong promoter of tumor progression., The aim of the present study was to determine glomerular immunoexpression of MMP-2 and MMP-9 in IgA nephropathy and Schoenlein-Henoch nephritis., The promoter polymorphisms associated with Pseudoxanthoma elasticum may lead to increased MMP2 expression and thereby contribute to the elevated proteolytic activity observed in PXE, opioids have an effect on matrix metalloproteinase-2 and -9 secretion and mRNA levels in MCF-7 breast cancer cell line, MMP-2 release and activation differentially degrades Abeta species, delaying their toxicity for endothelial cells., MMP-2 activity is associated with increase in MT2-MMP expression and with lymph node metastasis., a proportional significance of genetic polymorphisms in MMP-2 and MMP-9 genes in black and whitel subjects, MMPs are critical targets of diallyl disulfide-induced anti-invasiveness in human prostate cancer LNCaP cells., No significant differences were observed in MMP-2 frequencies/plasma levels between myocardial infarction patients and controls., The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression., The detected polymorphism in matrix metalloproteinase-2 gene was not associated with clinical response to cell therapy., High expression of MMP-2 and IGF-1 proteins is significantly correlated with the invasion and metastasis of gastric carcinoma., CD147 and MMP-2 play a role in invasion and metastasis of laryngeal carcinoma. Increased levels of MMP-2 and MMP-9 are induced by CD147 in laryngeal tumor cells., Inhibition of the PMA-Induced Expressions of MMP-2, MMP-9 and Cell Invasion, Migration via an Inactivation of the FAK/ERK Signaling Pathway by a-Mangostin, Visfatin enhanced the expression and activity of MMP-2 and MMP-9 in human monocytes via activating NF-kappaB signaling pathway., MMP-2 and MMP-9 in conjunction with VEGF-C, promote lymphangiogenesis and lymph node metastasis of breast cancer., An increase in MMP-2 mRNA and a decrease in TIMP-2 mRNA expression in uterosacral ligament are related to uterine prolapse in women without urinary incontinence., c-Cbl promotes glioma invasion through up-regulation of MMP2., Significantly higher venous levels of MMP-2 were associated with hemodialysis arteriovenous fistula maturation., Endothelin-1 is a lymphangiogenic mediator. Endothelin-1 induces MMP-2 and MMP-9 in lymphatic endothelial cells., 39% less extracellular MMP2 was measured from knockdown cells identifying one mechanism by which calpain 2 mediates glioblastoma cell invasion., No significant differences in either genotype distributions or allelic frequencies of MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R were found between patients with POAG and control subjects., The results obtained, therefore, rule out the existence of a negative correlation between ERK1/2 activation and MMP2 activity., metalloproteinase MMP-2 and MMP-9 -to-E-cadherin ratio has an effect on lymphangiogenesis and lymph node metastasis in prostate cancer, The association of polymorphism frequencies of MMP-2 C1306T and MMP-2 plasma enzyme activity in lung cancer patients, was investigated., Data show that a regulatory loop involving an opposing relationship between RKIP and the NF-kappaB pathway may control the level of MMP expression and cell invasion., Data show that mRNA expression of MMP-2 was only detectable in BL-28/0 and BL-13/0 bladder cancer cell lines., Low molecular-weight fucoidan increased in vitro human umbilical cell migration and decreased vascular smooth muscle cell migration in rats., Short-term use of statins is not associated in reducing levels of MMP 2 in areas of low and peak wall stress in patients with abdominal aortic aneurysms., High MMP2 is associated with peritoneal injury., TGF-beta1 induces dramatic elevation of MMP-2 activities and the MMP-2/tissue inhibitors of metalloproteinases ratio., Immunocytochemistry also revealed protein expression for MMP-2, 3, 8, 9 and 10 in cultured HUVEC., A positive correlation of serum MMP-2 with interleukin-1beta was observed with progressive-phase Guillain-Barre syndrome., extracellular Hsp90alpha promotes angiogenesis in an MMP-2-dependent manner., These results reveal a new mechanism by which beta3Gn-T8 can regulate MMP-2 and TIMP-2., results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma., our findings associate MMP-2 with glomerular injury as well as interstitial fibrosis and tubular atrophy observed in patients with chronic humeral kidney graft rejection., Thrombin-dependent MMP-2 activity is regulated by heparan sulfate, MMP-2 localizes to titin at the Z-disk region of the cardiac sarcomere and contributes to titin degradation in myocardial ischemia/reperfusion injury., Nicotinamide N-methyltransferase has a crucial role in cellular invasion via activating PI3K/Akt/SP1/MMP-2 pathway in clear cell renal cell carcinoma (ccRCC)., Restoration of MMP-2 expression in the Slug-silenced bladder cancer cells resulted in an increased cell angiogenesis., Expression of matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in papillary thyroid cancer, Data show there was a direct correlation between the degree of DSPP-silencing and suppression of MMP-2, MMP-3 and MMP-9., OPN enhanced hepatocellular carcinoma cells invasion through interaction with its receptor CD44v6 and increased MMP-2 and uPA expressions., These findings show that CK19 and MMP-2 expression may be beneficial in predicting lymph node metastasis in hepatocellular carcinoma and survival., The content of matrix metalloproteinases (MMP) -2, -7, and -9 was signifi cantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer., The present investigation is the first report to detect an association between MMP2 promoter polymorphisms and CAD with or without MI history in the Turkish population, Release of metalloproteases-2 and -9 is blocked after silencing of the kinin B1 receptor with a siRNA., the multifactor interactions among polymorphisms in MMP-2, FASL and FAS are associated with gastric cardia adenocarcinoma., MMP-2 expression thus appears to confer enhanced vascular proliferation particularly at the brain-tumor interface., reduced content of MMP-2 in ovarian cancer tissue compared to benign tumors were demonstrated by enzyme immunoassay. After preoperation chemotherapy the level of MMP-2 increased, Specific suppression of osteopontin also inhibited matrix metalloproteinase 2 (MMP-2) and urokinase-type plasminogen activator (uPA) expression in HCCLM6 cells., plays an important role in invasion and metastasis in squamous cell carcionoma of the tongue, results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 expression and enhance ovarian cancer cell invasion, MMP-2 inhibitor suppressed the Wnt-5a-dependent invasion of U251 cells, MMP2 and MMP3 genes do not correlate with a genetic risk of coronary restenosis after successful percutaneous coronary intervention., The increased MMP levels in our MG patients...suggest that MMP2, MMP3 and MMP9 play a role in the development of myastenia gravis, two SNPs on matrix metallopeptidase 2 gene and one SNP on tumor necrosis factor-alpha gene, are marginally associated with intracranial aneurysm in male- and female-specific manner, Phytic acid modulates MMP-2 gene expression in colon cancer cells at the transcriptional level in a way dependent on its concentration and time of interaction., The effect of estradiol on prostate cancer cell invasiveness via upregulation of MMP2 via a paracrine mechanism is reported., Specific single-nucleotide polymorphism in TIMP2 and MMP2/9 appeared to be associated with tumorigenesis and biological behavior in colorectal cancer., The expression of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin., Ursolic acid downregulated the expressions of MMP-2 and MMP-9 in ovarian carcinoma cells., Akt-dependent mechanisms of interference with motility/invasion of human glioblastoma cells, Resistin-stimulated vascular smooth muscle cell migration was associated with increased MMP expression, which was dependent on PKCepsilon activation., The findings suggest that matrix metalloproteinase 2 polymorphisms affect hypertension-induced left ventricular remodelling., The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. It is suggected BAG3 binds to MMP2 to positively regulate the process of cell invasion., MMP-2 is differentially expressed in central and peripheral regions of gliomas, A prognostic index in skin melanoma through the combination of matrix metalloproteinase-2, Ki67, and p53., MMP2 polymorphism is not associated with breast cancer., CD147 and MMP-2 were co-localized in spermatogonia, spermatocytes and round spermatids in mouse testis, while in human testis, they were co-localized in spermatocytes and round spermatids., mechanical injury, HIF-1alpha and inflammatory factors collectively induce increased MMP-2 production in anterior cruciate ligament fibroblasts, Des-gamma-carboxyl prothrombin stimulates HCC growth and promotes HCC metastasis by increasing the activity of MMP-2 and MMP-9 through activation of the ERK1/2 MAPK signalling pathway, Regions of aberrant DNA methylation which were consistent with alteration of TGM-2, MMP-2, and CD24 transcript and protein expression., There was no association between the genotypes of the MMP2, VEGF and HIF1A SNP and clinicopathological parameters of colorectal cancer., Overexpression of MMP-2 and MMP-9 are often associated with increased invasive metastatic potential of colorectal adenocarcinoma., Data show that MMP-2-conditioned dendritic cells primed naive CD4(+) T cells to differentiate into an inflammatory T(H)2 phenotype through OX40L expression and inhibition of IL-12p70 production., Results showed that exposure of human monocyte U937 to Nano-Ni caused dose- and time- dependent increase in MMP-2 and MMP-9 mRNA expression and pro-MMP-2 and pro-MMP-9 activity., Doxycycline reduced MMP-2 from MEFs and decreased active-MMP-2 from LAM cells., MMP2, TIPM2, and TIMP3 genes were not associated with high myopia in this Chinese sample and hence are unlikely to play a major role in the genetic susceptibility to high myopia., MMP-2 concentrations were lower in the plasma of patients with inguinal hernia and abdominal aortic aneurysm than controls., differences in histological features between nasal polyposis and chronic rhinosinusitis might be related to the expression of MMP-1, MMP-2, MMP-8 and their tissue inhibitor-2, Data indicate that the balance between MMPs and TIMPs in women with PCOS is altered, probably due to androgen excess found in these women., results indicated that WISP-1 enhances the migration of chondrosarcoma cells by increasing MMP-2 expression through the alpha5beta1 integrin receptor, FAK, MEK, ERK, p65 and NF-kappaB signal transduction pathway, MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of subcortical ischemic vascular disease., data demonstrate, for the first time, that DDR1 mediates MMP-2 and -9 secretions and invasion induced by native type IV collagen in MDA-MB-231 breast cancer cells, Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., The results showed that MMP-2 was significantly higher in the cases with vulnerable atherosclerotic plaque than in the cases with stable plaque., Results indicate the better usefulness of TIMP-2 than MMP-2 in the diagnosis of colorectal cancer, especially in combined use with classic tumor marker of CRC, e.g. carcinoembryonic antigen., A significant association of MMP-2 (-1306C/T) polymorphism with glioblastoma multiforme was not found, suggesting that MMP-2 (-1306C/T) polymorphism is not associated with increased GBM susceptibility., MMP2 levels are elevated in patients who experience atrial fibrillation recurrence after ablation., Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways, Both MMP-2 and MMP-9 were associated with the leukocyte count in pre hemodialysis group., The aim of this study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed., G-CSF-induced MMP-2 upregulation and invasive phenotype is mediated by Rac1., results suggest the greater importance of serum MMP-2 than of the classical tumor markers CEA and CA 19-9 in the diagnosis of gastric cancer, MMP1 and MMP2 may be useful biomarkers that can help stratify patients at higher risk of developing recurrence in colorectal cancer, and guide individualized treatment decisions to achieve better outcomes., Metastasis formation upon up-regulation of full length-L1CAM correlated with increased invasive potential and elevated Matrix metalloproteinase (MMP)-2 and -9 expression and activity., Matrix metalloproteinase-2 in preoperative serum is independent prognostic markers in patients with colorectal cancer, Serum MMP-9 level is a better marker than serum MMP-2 in predicting the breast cancer development and progression., Data show that suppression of microglial MMP-2 secretion by M tuberculosis-infected monocytes involves the pro-inflammatory mediators TNF-alpha, p38 MAP kinase and NFkappaB in addition to a novel caspase 8-dependent pathway., Results show that silibinin decreased MMP-2, MMP-9, u-PA, p-p38, and p-Erk1/2 expressions in a concentration-dependent manner., Expressions of LOX and MMP-2 in gastric cancer tissues are significantly higher than that in pericancerous tissues, and are also higher in gastric cancer with lymph node metastasis., There was no significant effect of MMP2 polymorphisms on mRNA expression., Knockdown of AURKA inhibits the growth and invasiveness of this LSCC cell line both in vitro and in vivo. These effects may partially result from the reduced expression of FAK and MMP-2., Coexpression of MMP-2/MMP-9 correlated significantly with tumor size in breast cancer., The allele frequency of MMP2 rs243865 was not associated with the development of gastric cancer or its lymph node metastases. Epistasis between PARP1 rs1136410 & MMP2 rs243865 increased the risk of LNM of GC., Serum levels of MMP-2/TIMP-2 were significantly higher in patients with matured arteriovenous fistulas vs levels in those that failed., The effects of rosuvastatin in reducing MMP-2 and MMP-9, which might stabilize the atherosclerotic plaques, are dose-dependent., There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues., MMP2 showed an increase in amniotic fluid of Down syndrome pregnancies., HABP1 enhanced melanoma cell migration, leading to MMP-2 activation and tumor growth., Although MMP-2 positivity was observed in 2 malignant cases, CD44 positivity was not associated with malignancy criteria in solitary fibrous tumors, Fluid shear stress in the tumor microenvironment may explain reduced glioma invasion through modulation of cell motility and MMP levels., The MAPK signaling pathway is a potential key intracellular modulator of Ang II-induced increase in MMP-2 activity and MMP-14 and BSG protein expression., Data show CCL23 stimulates chemotaxis of human THP-1 monocytes and enhances release of MMP-2, and suggest it plays a role in atherogenesis., The expression of COX-2, MMP-2 and VEGF in colorectal cancer plays a synergistic promoting effect on the malignant biological behavior of tumors., In conclusion, MMP-2 expression was related with worse overall and disease-free survival and could be considered as a potential marker of poor prognosis., Soluble endoglin may participate in the genesis of preeclampsia by affecting the invasive ability of cytotrophoblasts through regulation of the expression of MMP-2 and MMP-9., Results show that SLPI promotes the metastasis of SNU638 gastric cancer cells by increasing MMP-2 and MMP-9 expression through Elk-1 signaling, indicating its role as a signaling molecule not a protease inhibitor., This is the first report of a change in MMP-2 activity in Alzheimer's disease plasma and these findings may provide some insight into Alzheimer's disease pathogenesis, human leukemic Jurkat, U937 and Molt-4 cells display gene activity with different degrees, MMP-2 expression within and around amyloid-beta compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding., Findings show that the combination of intratumoral HIF-1alpha, VEGF, and MMP-2 may be useful as a molecular prediction model for LNM., Tumor MMP-2 high expression was not significantly correlated with poorer outcome in stage IA non-small cell lung cancer., meta-analysis showed evidence that MMP2 -1306T allele may be a protective factor for digestive cancer risk as well as a low-penetrance susceptibility digestive cancer biomarker, basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium, Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras., Two strongly linked snps in MMP9 showed significant associations with subarachnoid hemorrhage in men, MMP-2 genotype of donor and recipient is an independent risk factor for the development of nonanastomotic biliary stricures after orthotopic liver transplantation., AEG-1 plays a crucial role in osteosarcoma progression through upregulation of MMP-2, activated platelets may be a major source of MMP-1 and to a minor extent MMP-2, in peripheral blood., IL-17A could upregulate MMP2 and MMP9 expression via NF-kappaB signaling activation., results suggested that hypoxia might inhibit the invasive capacity and MMP2 activation of extravillous trophoblast cells in the early first trimester of pregnancy., Expression and activity of MMP-2 are strongly increased after exposure of human saphenous vein grafts to arterial hemodynamic conditions., Results suggest that decreased E-cadherin and increased MMP-2 may be associated with the capacity of GCSCs to metastasize., Our data suggested that variant allele of MMP2 1306C > T was associated with high risk of tumor recurrence and reduced recurrence free survival in superficial bladder cancer patients, results suggest that the MMP2 C(-1306)T polymorphism interacts with Hg exposure and affects MMP-2 and MMP-2/TIMP-2 levels; this interaction may increase the risk of developing diseases in subjects with the C allele, The crystal structure of the catalytic domain of MMP-2 in complex with APP-IP, was determined., Unlike in their adult counterpart, the expression of matrix metalloproteinase 2 or the loss of HLA class II antigens does not discriminate between benign and malignant tumors in children., The C-terminal domain of TIMP-2 inhibits cell surface activation of proMMP-2., overexpression of serum response factor in hepatocellular carcinoma may play an important role in tumor cell migration and invasion through upregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, Data suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS., Data show that CC and DW increased MMP-2 and MT1-MMP expression., Data show that kahweol inhibits HUVEC MMP-2 and urokinase involved in angiogenesis., The MMP2 -1306C/T promoter polymorphism is associated with nasopharyngeal carcinoma risk, and this association is especially noteworthy in heavy smokers., study demonstrates the potential utility of urinary MMP-2 and MMP-9 to differentiate between ovarian cancer patients with normal CA125 levels and controls, fibulin-3 negatively modulates the invasiveness of lung cancer cells via regulation of MMP-7 and MMP-2 and its expression is regulated by hypermethylation of the promoter region, MMP-2 levels may be of value in understanding the pathogenesis and progression of alcoholic cirrhosis, Recombinant human osteopontin up-regulates MMP-2 through the SDF-1alpha/CXCR4 axis., CD147 and MMP-2 expression is correlated with the invasion and metastasis of squamous cell carcinoma and adenocarcinoma of the lungs, Report activity of MMP2/9 and TIMP-1 in electromagnetic field-exposed THP-1 cells., mRNA and protein levels of MMP-2 in hypoxic cells increased in both anterior cruciate ligament (ACL) and medial collateral ligament cells, however, in ACL pro-MMP-2 was converted into a more active form, This is the first study to show that endogenous nitric oxide formation correlates negatively with the circulating levels of both MMP-2 and MMP-9 in black subjects, These data testify to the important role of metalloproteinases 2 and 9 in extracellular interaction and proliferation activity in thymus aging., Data show that SNPs in the MMP-2 and -9 promoter region may be associated with susceptibility to and neck squamous cell carcinoma not in oral submucous fibrosis., study identified urotensin-II and NOX4 as new activators of FoxO3a, and MMP2 as a novel target gene of FoxO3a, and showed that activation of FoxO3a by this pathway promotes vascular growth, Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer.(, analysis of secretory dynamics of MMP-2 and the specific sites for polarized distribution of MMP-2 on the cell surface, Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9., Down-regulation of Notch1 could be an effective approach for inhibition of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the inhibition of invasion and metastasis., The results suggest that the main proteolytic cascade, MMP-2/MMP-13/MT1-MMP is involved in osteoblast differentiation through mechanical forces., A significant inverse relationship between miR-29a and total MMP-2 was identified in the thoracic aortic aneurysm specimens., Matrix metalloproteinase-2 promoter gene polymorphisms are associated with non-Hodgkin's lymphoma., MMP-2 might be a prognostic marker in ascites of advanced gastric patients with disseminated metastasis., The role of MMP-2 expression in the prognosis of invasive ductal carcinoma of the breast is rather limited., no significant association was observed between MMP-2 polymorphisms and treatment efficacy, including response rate, clinical benefit, progression-free survival, and overall survival., MMP2 and neutral sphingomyelinase-2 play a role in vasculopathy triggered by a humoral immune response in transplants., Zoledronic acid can inhibit the in vitro proliferation and invasion of HNE1 cell through suppressing the secretion of VEGF and suppressing MMP2 and MMP9 activity., NDRG2 contributed to an increase in the ratio of matrix metalloproteinase 2 (MMP2) to tissue inhibitor of matrix metalloproteinase 2, Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis, There was no association of MMP2 polymorphism and occurrence and development of gastric cancer., COX-2 and MMP-2 produced from human brain endothelial cells facilitate the extravasation of breast cancer cells across the BBB, an increase in the immunodistribution of MMP-2 and -9 and TIMP-1 and -2 in lichen sclerous compared to normal vulvar skin was observed., ADAM17 contributes to androgen-independent prostate cancer cell invasion by shedding of EGFR ligand TGF-alpha, which subsequently activates the EGFR-MEK-ERK signaling pathway, leading finally to overexpression of MMP-2 and MMP-9., Failed to demonstrate any prognostic relevance of MMP2 levels in advanced epithelial ovarian neoplasms., Abnormal expressions of MMP-2 and TIMP-1 can promote the development of renal fibrosis in chronic active antibody-mediated renal graft rejection., Paroxysmal atrial fibrillation (AF) was associated with higher MMP-2 levels compared to permanent AF., Human cardiomyocytes express an MMP-2 splice variant which entirely lacks the signal sequence., AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9., Data show that Tissue factor (TF) down-regulation diminished matrix metalloproteinases MMP-2 and MMP-9 expression and promoted reversion to suspension growth., No correlation was found between pinopodes development stage and MMP2 expressions in endometrium, It is concluded that MMP-2 may be involved in ADM resistance dependent on ERK1/2 signal pathway, suggesting interference in ERK1/2 may be a new method of targeted therapy for tumor resistance., Between two of the tested metalloproteinases (MMP-2 and MMP-11) only MMP-2 appears to have prognostic significance in early forms of breast cancer, and its strong expression is associated with shorter survival., This study demonistrated that Expression of MMP-2 was significantly more extensive in mesenchymal than in glial tumor areas., These findings suggest that corticotropin-releasing hormone might induce invasion and migration by upregulating MMP-2 and MMP-9 in endometrial cancer., HDAC inhibitor trichostatin A (TSA) increased the expression of TIMP-1 and TIMP-3 while decreased MMP-2, MMP-9 and uPA and have an inhibitory effect on trophoblast invasion., MMP-2 genotypes or haplotypes modify MMP-2 levels in end-stage kidney disease patients. The T allele for the C-735T polymorphism and the C-T haplotype were associated with higher MMP-2 levels (p < 0.05), whereas the C-1306T had no effects., close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues of uterine leiomyomas., results are the first to demonstrate that triple-helical peptides are suitable for highly specific in vivo detection of tumor-related MMP-2 and MMP-9 activity, Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosus patients., Pregnant women with pre-eclampsia had higher plasma MMP-2 and TIMP-2 concentrations than healthy pregnant women. MMP-2 genotypes and haplotypes were associated with significant alterations in plasma MMP-2 and TIMP-2 concentrations in preeclampsia., Activated MMP-2 in hyperostotic lesions may change the physiological metabolism of the skull bone, thus playing an important role in hyperostosis formation., Blocking the FAK signaling pathway can reduce the activity of MMP-2 and -9 in corneal epithelium treated with TNF-alpha., study concludes that MMP-14 (via its ability to activate proMMP-2) and MMP-2 are key proteases in collagen contraction mediated by fibroblasts in Dupuytren's disease patients., the possible role of MMP-2/alpha5beta1 interaction in the regulation of alpha5beta1-mediated IL-6/Stat3 signaling activation, findings suggested MMP2 variants as a predictor of PCa progression risk among North Indian men, expression correlates with severity of chronic rhinosinusitis with nasal polyposis, Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2, the present study shows for the first time that MMP-2 and -9 give a main contribution to estrogen's neuroprotective effect., MMP2 -735 C/T and MMP9 -1562 C/T functional gene polymorphisms might be associated with an increased risk of idiopathic recurrent spontaneous abortion in women., Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of Behcet Disease, while MMP-9-1562*C/*C may promote the disease., that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner., The MMP2 -735 T/T genotype was statistically significantly associated with a decreased survival in non-small cell lung cancer (NSCLC), The highly significant correlation between VEGF and MMP-2 suggests a connection between both mechanisms in the progression of gastric cancer., High MMP-2 is associated with colorectal cancer., New mechanistic insight into how lymphatic endothelial cells negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis., Notch1, MMP-2 and MMP-9 are closely correlated with the progression and prognosis of malignant gliomas. Notch1 may participate in the expression regulation of MMP-2 and MMP-9., COUP-TFII negatively regulates osteoblast differentiation via interaction with Runx2, and during the differentiation state, BMP2-induced Runx2 represses COUP-TFII expression and promotes osteoblast differentiation., A novel N-terminal truncated intracellular isoform of MMP-2 is induced by oxidative stress., Serum vascular endothelial growth factor (VEGF)-D is significantly elevated in patients with lymphangioleiomyomatosis and is a better diagnostic marker than matrix metalloproteinase (MMP)-2, MMP-9 and ACE., Nox1 was overexpressed in all melanoma cell lines examined, and enhanced cell invasion by MMP-2 upregulation and EMT induction, Variations in MMP2 are associated with periapical lesion formation in individuals with untreated deep carious lesions., These results suggested that the inhibition on proMMP-2 expression by Liquiritigenin may be through suppression on PI3K/Akt signaling pathway, which in turn led to the inhibition of lung adenocarcinoma A549 cells migration., These data show that overexpression of Aurora-A contributes to the malignancy development of ESCC by enhancing tumor cell invasion as well as MMP-2 activity and expression, COX-2 increased the expression of MT1-MMP, which in turn activates MMP-2, the release of pro-inflammatory TNF-alpha, MMP-9, and MMP-2 was higher in cells exposed to oxidized high density lipoproteins (HDL) than those exposed to native HDL, noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells, The increased expression of MMP2 plays a crucial role in the development of several human malignancies, including esophageal cancer., VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2., Enhanced stromal MMP-2 expression in in situ and invasive squamous cell carcinoma relative actinic keratosis suggests role in disease progression., Grp78 knockdown inhibited ECM degradation and the decreased activity and expression of MMP-2, Inhibition of MMP-2 by doxycycline delays the progression of Marfan syndrome., cysteine-rich angiogenic inducer 61 may promote trophoblast cell migration and invasion through upregulation of NUR77 protein leading to the increase of matrix metalloproteinase 2(MMP2) release and the downregulation of tissue inhibitor of MMP2 expression, Our experimental data suggest a novel regulatory mechanism for pro-MMP-2 activation that is modulated through homodimerization of MMP-2., We detected reduced plasma levels of zinc and MMP-2, and enhanced plasma levels of SOD in patients with keratoconus compared with the healthy subjects., Data show that angiotensin II through activation of AT1 receptors can stimulate the expression of MMP-2, MMP-13 and VEGF, but not MMP-13, in B16F10 melanoma cells., MMP2 plays a critical role in TGFbeta2-mediated matrix contraction. MMP2 inhibition provides a novel strategy for the treatment of PCO and potentially other fibrotic disorders., This study suggests that genetic variants in MMP-2,7,9 and TIMP-2genes are associated with higher susceptibility of gallbladder cancer., Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10., finding of increased plasma activity of matrix metallopeptidase 2 in overweight/obese women, associated with menopausal status, is important given that it fits in with an early stage of cardiovascular disease, Platelets do not possess the transcriptional activity of a gene encoding MMP-2., MMP-2 is involved in the granulocyte-colony stimulating factor stimulation of trans-stromal migration of hematopoietic cells., hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK activation in pancreatic cancer, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Strong MMP2 staining is associated with worse survival of melanoma patients., MMP-2 polymorphisms do not affect the susceptibility to hypertensive disorders of pregnancy, nor do polymorphisms affect the responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy., SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell., basal lamina type IV collagen alpha chains, matrix metalloproteinases-2 and -9 expressions are expressed in oral dysplasia and invasive carcinoma, Data suggest that lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of MMP-2 and urokinase-type plasminogen activator via vascular endothelial growth factor receptor 2 signaling., Low MMP-2 plasma levels are associated with intracranial location of cerebral atherosclerosis., Serum MMP-2 and PAPP-A were independent correlates of proteinuria, albumin, and other examined parameters in patients with chronic kidney disease., The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction., Roles for MMP-2 and TIMP-2 in both thyroid development and malignant transformation., Glut-1 may regulate MMP-2 and MT1-MMP expression in laryngeal carcinoma., MMP-2 over-expression is a poor prognostic factor for survival in patients with colorectal cancer., This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis., MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., fluid shear stress involved in PDL remodeling via regulating MMP-1, 2 and TIMP-1, 2 expression. ERK regulated fluid shear stress induced MMP-1 expression and P38 play a role in fluid shear stress induced MMP-2 upregulation., MMP-2 and MMP-9 downregulation in gallic acid treated K562 cells are mediated through suppression of JNK1-mediated c-Jun/ATF-2 and Akt/ERK-mediated c-Jun/c-Fos pathways, respectively., MMP2 mutations can result in osteolytic disorders., LOX, MMP-2, and MMP-9 may have a synergistic role in promoting invasion and metastasis of breast cancer., MMP-2, MMP-9 and TIMP-2, TIMP-1 may play an important role in the development, progression, invasion and metastasis of non-melanoma skin cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., High MMP2 expression is associated with follicular thyroid carcinoma., Data suggest that OSM enhances invasion activities of extravillous trophoblasts during placentation through increased enzyme activity of MMP-2 (primarily) and MMP-9 (to some extent)., with the exception of MMP-2, this study confirms the importance of MMPs in development of preeclampsi, currently available evidence supports the conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians, High MMP2 expression is associated with hepatocellular carcinoma invasion., Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways., patients with cardioembolic stroke had significantly higher MMP-2 concentrations in comparison to all other stroke subtypes, synergetic pathways of IL-17A and hypoxia might contribute to the migration and invasion of rheumatoid arthritis synoviocytes by up regulating the expression of MMP2 and MMP9 by activation of the NF-kappaB/HIF-1alpha pathway, MMP2 expression in tumor infiltrating CD3 lymphocytes is not associated with endometrial cancer., This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer., gene polymorphism is associated with advanced-stage endometriosis in Korean women, Data show that knockdown of CD147 inhibited MMP-2 activity of GnT-V-overexpressing cells, indicating that aberrant beta1,6-branches on CD147 is crucial for the induction of MMPs (matrix metalloproteinases) in SMMC-7721 cells., Data indicate that calpain-1 plays a pivotal role in matrix metalloproteinase 2 (MMP2) activation and extracellular matrix remodeling, including fibrosis and vascular calcification., Temocaprilat bound to the MMP-2 active centre., SIRT1 is an important regulator of MMP2 expression, activity, and prostate cancer cell invasion., the CC genotype for C(-735)T polymorphism and the CC haplotype were associated with higher plasma MMP-2 concentrations in MA group., Abnormal expression of MMP-2 and TIMP-1 might play roles in the development of renal fibrosis in chronic antibody-mediated renal graft rejection., study investigated the role of uPA, PAI-1, MMP-2, and TIMP-2 in formation of self-assembled network in the 2D co-ulture of bone marrow stromal cells and HUVECs; data showed that uPA played an important role in network formation, while the process appears independent on TIMP-2 but involved MMP-2, MMP-1, MMP-2 and MMP-9 were significantly more expressed in nasal polyps than in controls., After exposure to hypoxia, HIF-1alpha protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1alpha mRNA showed no significant change, Report up-regulation of MMP-2 in hidradenitis suppurativa., Variants in MMP1 through MMP10 and MMP2 regions seem to affect population variation in ocular refraction in environmental conditions less favorable for myopia development., No difference was found among groups for serum MMP2 for Takayasu arteritis., Degradation of ColIV was closely related to increased MMP-2 and MMP-9 expression; MMP-9 have more important function than MMP-2 during the cancer development, Data suggest that MMP2 and MMP9 have dual roles in Trypanosoma cruzi infection of placental chorionic villi; these enzymes may be partially responsible for invasion of extracellular matrix and may be part of local placental antiparasitic mechanism., alpha-Tomatine inhibited 12-O-tetradecanoylphorbol-13-acetate-induced expressions of MMP-2 and MMP-9 in MCF-7 cells., Mere15 inhibits tumor growth via both pro-apoptotic and antimetastasis pathways by reducing MMP2/9 expression., In patients with NASH, gene expression of MMP2, a protein associated with liver fibrosis, was enhanced in the liver tissue and serum levels of MMP2 were increased, indicating the initiation of liver fibrosis in this subpopulation, Heavy smoking noticeably increases native MMP2 and MMP9 gene expression in the SV before CABG., The expression of Twist1 has a close relationship with MMP-2 in endometrial endometrioid adenocarcinoma., Presented data suggest an implication of MMP-1 polymorphisms in the laryngeal carcinoma susceptibility. The presence of the MMP-1 2G allele seemed to be associated with increased risk for the disease., NK1R is a potential regulator of human glioma cell migration by the up-regulation of MMP-2 and MT1-MMP, Advanced pelvic endometriosis severity is related to higher serum MMP-2 levels but does not influence follicular MMP-2 or MMP-9 levels in periovulatory follicles obtained from stimulated cycles., MMP-2 overexpression is associated with poorer overall and progression-free survival in patients with CRC., Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., miR-200b enhances matrix metallopeptidase 2 (MMP2) activity by downregulating TIMP2 expression in endometrial adenocarcinoma HEC-1A cells, our findings have identified inhibition of MMP-2 and -14 expression and MMP-dependent migration as a novel mechanism by which angiostatin inhibits angiogenesis under pathological-like conditions., expression of MMP2 protein was inhibited by knockdown of MACC1 protein expression in hepatocellular carcinoma cells, blood pressure is associated with circulating MMP-2, the CC genotype for the C(-1306)T polymorphism was more common subjects with higher MMP-2 concentrations, the CT genotype and the T allele for the C(-735)T polymorphism are less common in obesity., Interaction between PAK4 and MMP-2 regulated anoikis, cell migration and invasion in glioma., There was no significant difference in MMP-9 and MMP-2 expressions between recurrent and nonrecurrent nasal polyps., these findings demonstrate that normal and tumor prostate cell lines express MMP2 activity when in contact with extracellular matrix components or blood plasma proteins such as fibronectin, The aim of the present study was to investigate the diagnostic significance of MMP-2 and TIMP-2 serum levels in esophageal cancer patients in relation to clinico-pathological features of cancer., The aim of this study is to demonstrate a relationship between MMP-2 secretion and activation and changes of glutathione/oxidized glutathione ratio in intestinal subepithelial myofibroblasts., We conclude that MnSOD may promote tumor aggressiveness via upregulation of the FoxM1-MMP2 axis, and that MnSOD expression can independently predict survival and relapse in patients with resected lung adenocarcinoma., p53, MMP-2 and MMP-9 can be used for the histological grading of oral Squamous cell carcinoma and its differentiation from Verrucous carcinoma, analysis revealed that MDR1 expression in lymph node was not correlated with MMP-2 expression in lymph node, number of metastasized lymph nodes and tumor size, our study suggests that evaluation of beta-catenin and MMP-2 expression may have potential in diagnosis and progression in patients with non-small cell lung cancer., Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9., MMP2-1306 C/T polymorphism decreased lung cancer risk in Asians., elevated levels of matrix metalloproteinase 9 and matrix metalloproteinase 2/tissue inhibitor of matrix metalloproteinase-2 complex may play a role in spontaneous termination of pregnancy, MMP-2 secretion is decreased in multiple myeloma after treatment with anti-angiogenic agents, expression correlates with clinical stage in non-small cell lung cancer, HPV 16 E6 up-regulates pro-angiogenic MMP-2 and MMP-9 through inducing IL-8 expression in lung cancer cells., TGF-beta1 induced injured ACL to express more MMPs than injured MCL fibroblasts (up to 2.33-fold in MMP-1, 2.45-fold in MMP-2, 1.89-fold in MMP-3 and 1.50-fold in MMP-12), A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women, Low MMP2 levels are associated with grade 3 breast tumors., MMP2 is responsible for high myopia in these Han Chinese subjects and hence is unlikely to be important in the genetic predisposition to high myopia., The role of MMP-2 in the regulation of SDF-1/CXCR4 signaling-mediated angiogenesis in endothelial cells., the evaluation of MMP2 in thyroid Papillary thyroid carcinoma appears to be of some benefit to the prediction of tumor behavior while Caspase-3 as a marker of prediction seems to be of no use., MMP-9 and MMP-2 are highly expressed by myeloma cells., The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma., Report MMP2 activity in chronic pancreatitis and pancreatic adenocarcinoma., High stromal MMP 2 expression were identified as a significant determinant for endometrial cancer recurrence, while epithelial MMP 2 expression and epithelial and stromal MMP 9 expression were not., analysis of a highly selective and strong protein inhibitor against matrix metalloproteinase-2, Placental MMP2 and MMP3 levels are higher in women delivering preterm as compared with term and may favor degradation of extracellular matrix in the placenta during preterm labor., hCGbeta induced cell motility via promoting ERK1/2 phosphorylation and MMP-2 upregulation in human prostate cancer DU145 cells., MMP-2 is upregulated in brain microvascular endothelial cells following induction of basement membrane hypertrophy by advanced glycation end-products., The expression of pro-invasive gene matrix metalloproteinases 2 is also reduced by miR-22 expression., Decreases in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes increase the risk for lung cancer., PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells., liver chimerism in MMP-2 was found to be significantly associated with the development of acute cellular rejection after orthotopic liver transplantation., Hypomethylating drug 5-azadC and histone deacetylase inhibitor trichostatin A induced modulations in higher order chromatin organization and in MMP-9 and MMP-2 expression in human HT1080 fibrosarcoma cells., Simvastatin and rosuvastatin significantly and dose-dependently reduced RAS protein, MMP-2/9 and NF-kappaB-p65 expression in tumor cells., role of SPARC, MMP-2 and MMP-9 in intracranial aneurysms, MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants are unlikely to have a major role in age-related macular degeneration risk susceptibility., the inhibitory effect of TSA on cancer invasion is mediated through the suppression of HDAC2 expression, and the reduction of MMP-2 and MMP-9 expression induced by HDAC2 may be involved in the anti-invasive effect of TSA, Increases in circulating MMP-2 are associated with poor oocyte and embryo development in women with endometriosis undergoing in vitro fertilization., This pilot study first reveals a link between increased levels of circulating gelatinases (MMP2 and MMP9) and polypoidal choroidal vasculopathy but not age-related macular degeneration., Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression., Daidzein, R- and S-equol inhibit the invasion of MDA-MB-231 human breast cancer cells in part via the down-regulation of MMP-2 expression, with equipotent effects observed for the parent isoflavone daidzein and the equol enantiomers., Increased MMP2 expression was found in nasopharyngeal carcinoma. In lymph node metastatic NPC, NPC cells had a higher rate of MMP-2 expression in tumor metastases than in the primary tumor., Positive correlations of MMP1, TIMP1 and 2 with pancreatic tumor diameter (CP) were observed, and MMP2 with the duration of surgery and blood loss, MMP-2 EPHA2 signaling contributed to tumor growth and vasculogenic mimicry of gallbladder carcinomas., MMP-2 positivity in tumor cells is associated with worse survival in patients with gynecological cancers., FRET sensors fabricated through physical adsorption, the as prepared ones via covalent binding are significantly more stable under physiological conditions, enabling their detection of MMP-2 with high sensitivity (detection limit, the MMP2-1306 C>T polymorphism is associated with the risk of HNC, as is the MMP3-1171 5A>6A polymorphism specifically in some subgroups. However, the MMP9-1562 C>T polymorphism is not associated with HNC risk., Interstitial collagenase, gelatinases A and B and their endogenous inhibitors in squamous cell cervical carcinomas, Although extracellular galectin-3 accumulates due to the decrease in MMP-2 activity, galectin-3 signaling events are blocked due to an impaired interaction with 4F2hc, inducing an increased degradation of beta-catenin., The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas., MMP-2 -1306C > T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed., MMP-2 plasma levels are significantly increased in metabolic syndrome., Uterine leiomyosarcoma showed strong bands corresponding to inactive and active MMP-9 and a faint band corresponding to MMP-9 dimer induced with PMA treatment, but no MMP-2 band., Data indicate that a 2-week course of antibiotics and corticosteroids effectively improves the uterine environment underlying recurrent implantation failure (RIF) by reducing MMPs MMP2 and MMP9 activity., The levels of MMP2, MMP9, TIMP1, and TIMP2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those with benign thyroid disease and healthy volunteers., The MMP-1,2 levels were statistically higher in epitheliocytes, macrophages and capillaries endotheliocytes in all instances not depend on the sex and correlate with mucosa disease activity, IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2, Up-regulation of both MMP-2 and CD44v6 is significantly correlated with the development of lateral cervical lymph node metastasis in patients with papillary thyroid carcinoma., The PAK5-Egr1-MMP2 signaling pathway is a critical regulator of cell migration and invasion in lung cancer cells., MMP1 [4 single nucleotide polymorphisms (SNPs)] and MMP2 (2 SNPs) were associated with breast cancer overall., enzyme activity assays confirmed increased MMP-1, -2, and -3 activity in cancer myofibroblasts, and cancer cell migration assays indicated stimulation by MMP-1, -2, and -3 in cancer-associated myofibroblast media., Glycosylation of teh extracellular domain of EMMPRIN is a prerequisite for efficient MMP-2 production., Our data suggest that gene polymorphisms of MMP-2 may have a protective role in the progression of primary open-angle glaucoma in a Polish population., Suggest that miR-491 is involved in metastasis of hepatocellular carcinoma by blocking epithelial to mesenchymal transition and decreasing MMP2/9 levels., RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells., Positive expression rate of MMP-2 in gastric cancer tissues was 44.35%, negative in normal gastric tissues., This study suggests an effective link between MMP-2 and HLA-G1 shedding., These data illustrate the complex interaction between the substratum and PRL/PAK1 signaling in human breast cancer cells and suggest a pivotal role for PRL-dependent PAK1 tyrosyl phosphorylation in MMP secretion., The cold chloroform extract of Lansium domesticum appeared to contain anticancer active compounds against KB cells because of its high anti-proliferative and MMP-2 inhibition activities., Androgen blockade decreases serum PSA by eliminating HER-2 negative prostate cancer cells., Highest concentration of MMP-2 was found in patients with unresectable pancreatic cancer., Distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia predict that this enzyme determines the presence of multi-organ failure of the connective tissue., Dihydrotestosterone levels differentially affected the expression of regulatory isoforms responsible for the activation and inhibition of MMP-2., MMP2-1306C/T, but not TIMP2G-418C, gene variants are a risk factor for the development of retinal vein occlusion., increased expression of MMP-2 metalloproteinases is responsible for disturbed equilibrium of the metalloproteinase/tissue inhibitors system and as a consequence, for destabilization of atherosclerotic plaque and occurrence of the acute coronary syndrome, we use real-time PCR and Western blotting to demonstrate for the first time that MMP-2 expression is regulated by MT1-MMP in human endothelial cells, Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2,-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 cells., the shRNA-mediated inhibition of Bmi-1 reduced the invasiveness of two HCC cell lines in vitro by downregulating the expression and activities of matrix metalloproteinase (MMP)-2 and MMP-9 and vascular endothelial growth factor (VEGF)., Matrix metalloproteinase-2 C to T-1306 gene promoter polymorphism in primary sclerosing cholangitis is an independent risk factor for disease severity as reflected by the need for transplantation or disease progression leading to mortality., Data suggest active form of vitamin D, 1,25-dihydroxy-vitamin D3, down-regulates expression of MMP2 and MMP9 in uterine fibroid/neoplastic cells; 1,25(OH)2-D3 inhibits activities of MMP2/MMP9 via up-regulation of TIMP1/2 (tissue inhibitors of MMPs)., Data suggest that expression of CXCL6 (granulocyte chemotactic protein 2) in trophoblasts is up-regulated during pregnancy placentation; CXCL6 expression inhibits trophoblast cell migration and invasion by down-regulating activity of MMP2., human brain microvascular endothelial cells switch to a proinflammatory state by means of an enhanced production of MMP-2, attenuated release of TIMP-1, and unaffected production of TIMP-2, PTEN and MMP-2 immunoexpression in ectopic endometrial foci cannot be used to identify women with an increased risk of neoplastic transformation., S100A4 plays a crucial role in proliferation and migratory, invasive processes in human renal cell cancer by a mechanism involving activation of NF-kB-bcl-2 and NF-kB-MMP-2 pathway, data imply that MMP-2 and MMP-9 activities may play a role in the pathogenesis of ventricular septal defect, polymorphism of MMP2 may be associated with the risk and severity of lumbar disc degeneration in the Chinese Han population, Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2., Estrogen increased the expression of VEGF, and thus activate ERK1/2 pathway to induce MMP-2/9 expression., MMP2 was upregulated in osteosarcoma., HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis, U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer, Rab40b mediates trafficking of MMP2/9 during invadopodia formation and metastasis of breast cancer cells., Both cathepsin L and matrix metalloprotease-2 showed correlation with some of the clinicopathological parameters in pancreatic cancer but only cathepsin L expression in tumor epithelium predicted a poor prognosis for the disease., Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma., Circulating MMP-2, -3 and -9 are independently associated with kidney disease progression in non-diabetic chronic kidney disease patients and add incremental predictive power to conventional risk factors., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, The study investigated CD147 and MMP-2 expression in epidermis of cutaneous squamous lesions, Dephosphorylation of MMP-2 affects the conformational structure of the enzyme., These studies provide direct evidence that targeting MMP-2 will effectively protect against collagen and occludin loss and HT after ischemia and reperfusion., osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression., AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma., The MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population., Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety., the present study provided strong evidence to suggest that the MMP-2 rs243865 C/T polymorphism may be associated with reduced risk of AS. Further studies are needed to confirm the results of this preliminary study., Letter, These observations suggest a crosstalk between monocytes and human renal mesangial cells via the interaction of MMP2 and fractalkine., MMP2/TIMP2 and MMP9/TIMP1 immunoreactivity was extremely heterogeneous within the analyzed group of secondary liver tumors., Only MMP-9 Rs3918242 (C->T) single nucleotide polymorphism was found to play a significant role in the development of AMD, and the effect was more pronounced at the age of less than 65 years., CD147 promotes melanoma progression through hypoxia-induced MMP2 activation., The present study evaluated the serum levels of specific metalloproteinases (MMP-2 and MMP-9) and investigated the gene TGFBR in 28 patients with aortic valve disease associated with ascending aortic dilatation., An association between MMP-2 and RAS cannot be ruled out but we could not find strong evidence to support it, while an association of the TIMP-1 gene with RAS was ruled out based on our results., These data indicate that amsacrine induces MMP-2/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability in human leukemia cells., MMP-2 regulates human platelet activation through hydrolysis of talin, The strong expression of MMP-2 accompanied by reduced immunostaining of both TIMPs is associated with the development of the SV graft disease and unfavorable Coronary Artery Bypass Grafting outcomes, Data from model complexes of MMP-2 and triple-helix peptide fragments of COL2A1 (collagen, type II, alpha 1) suggest that the triple helix is distorted to allow the accommodation of an individual peptide chain within the MMP active site., Signal enhancement of silicon nanowire-based biosensor for detection of matrix metalloproteinase-2 using DNA-Au nanoparticle complexes., MMP2 could promote the migration and invasion of BC cells., Expression of MMP2 and MMP3 mRNA was significantly lower in NRD1-knockdown TE5 cells., MMP-2 and sLe(x) were negative prognostic markers for survival in these head and neck squamous cell carcinoma patients., Our results show that cytokines, mitogens and inducers show variable upregulation of U2OS osteosarcoma and RD rhabdomyosarcoma MMP-2 and -9 secretion., Common sequence variants and haplotype of MMP2 (-1575 G>A and -168 G>T) might be a genetic risk for the development of Metabolic Syndrome X in the North Indian population., which showed that MMP2 was higher in oral squamous cell carcinoma cancer tissues than adjacent tissues, autocrine secretion of MMP-2/9 by brain microvascular endothelial cells induced by humoral factors, other than IgG, in sera obtained from neuromyelitis optica patients potentially increases blood-brain barrier permeability, The serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects., KLF4 protein expression was inversely correlated with MMP2., Matrix metalloproteinase-2 (-1306 c>t) promoter polymorphism is associated with the risk of colorectal cancer., the lack of Gly-Asp-Lys clusters may diminish potential MMP-2 and MMP-9 collagenolytic activity. The present study indicates that MMPs have interactions spanning the P23-P23' subsites of collagenous substrates., The highest levels of MMP-2 and MMP-9 activities are found in the basal plate and extravillous trophoblast cells in women with undifferentiated connective tissue dysplasia., In right colon adenocarcinoma tumors, MMP2, p53, and beta-catenin gene expressions were higher than when compared to left colon., Amyloid-beta can regulate the proinflammatory state of human macrophages by inducing MMP-2/MMP-9/cathepsin S levels and by reducing TGF-beta1 secretion., Different expression of MMP-2 and MMP-9 regarding differential hormonal receptor expression could indicate distinct mechanisms of their regulation in breast neoplasms., The expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 1 (TIMP1), interleukin 6 (IL-6), and interleukin 15 (IL-15)., Higher serum MMP-2 levels and MMP-2/TIMP-2 ratio could predict poor prognosis after TACE, suggesting prognostic role of these biomarkers in HCC., The expression of protein and mRNA of MMP9 and E-cadherin following treatment with PGE2 were suppressed and increased by celecoxib, respectively; however, MMP2 showed no change in A549 cell., TIMP-2 seems to be a predictor of gastric tumor progression, especially for nodal involvement, whereas serum MMP-2 might be useful as an independent prognostic factor of patients' survival., The alphavbeta6 effect on bone loss is due to upregulation of soluble MMP2., POU5F1 enhances the invasiveness of cancer stem-like cells in lung adenocarcinoma by upregulation of MMP-2 expression., Finasteride significantly downregulated MMP2 and MMP9 activities in RWPE-1 and PC3 cells and MMP2 in DU145 cells., These data highlight a novel MT1-MMP/MMP2/RAC1 signaling axis in melanoma., results suggest that the MMP-2-1306 C/T and MMP-9-1562 C/T polymorphisms are significantly associated with bladder cancer susceptibility, and no associations were found between MMP-9-1562 C/T polymorphism and bladder cancer susceptibility, MMP-2 and TIMP-2 might play a role in the process of colorectal cancer invasion and metastasis, Id4 has a role in suppressing MMP2-mediated invasion of glioblastoma-derived cells by direct inactivation of Twist1 function, Serum and to a larger extent sputum MMP-2 appear to be potential noninvasive markers for detecting lung cancer., In acute ischemic stroke patients, MMP-2 levels are associated with the pre-existing burden of white matter hyperintensity., Elevated serum MMP2 levels in firefighters after the World Trade Center attack increase the odds of resistance to lung injury., MMP2 over-expression enhanced the MICA shedding, indicating that MMP2 was involved in the renal-cell-carcinoma-associated proteolytic release of soluble MICA, which facilitated the tumor immune escape., Matrix metalloproteinase-9 overexpression is associated with colon cancer., Matrix metalloproteinases (MMP)--MMP-1,-2,-9 and its endogenous activity regulators in transformed by E7 oncogene HPV16 and HPV18 cervical carcinoma cell lines, Thus the high MMP-2/MMP-9 ratio (> or = 1.8) may be associated with unfavorable course of AML., the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma, Expression of MMP-2 during ovarian follicular development was identified., Atherosclerotic plaques exert a prothrombotic effect by potentiating platelet activation due to their content of MMP-2; an elevated MMP-2 activity in plaques is associated with a higher rate of subsequent ischaemic cerebrovascular events., The resulting fusion protein was then used to target pancreatic cancer cells (PANC-1) in vitro. M-CTX-Fc decreased MMP-2 release into the media of PANC-1 cells in a dose-dependent manner, Spearman correlation analysis revealed that HIF-2alpha and MMP-2 expressions were significantly correlated (r = 0.990; P = 0.041)., High expression of matrix metalloproteinase 2 is associated with squamous cell carcinoma of the vulva., findings support an unrecognized interplay between ANG, ERK1/2 and MMP2 that can impact tumor growth and progression., Activation of endothelial MMP-2 by MMP-9 contained in neutrophil extracellular traps (NETs) is an important player in endothelial dysfunction. Aberrant NET formation plays pathogenic roles in systemic lupus erythematosus., Data indicate that silencing of alpha-fetoprotein led to an increased apoptosis, which was associated with a decreased expression of vascular endothelial growth factor, vascular endothelial growth factor receptor 2, matrix metalloproteinases-2/9., Concomitant increase in the expression of both MMP-2 and TIMP-2 in oral leukoplakia suggests that the activation of MMP-2 is dependent on TIMP-2 acting as a cofactor., Data suggested that IL-6 mainly promotes the cell migration and invasion of Nasopharyngeal carcinoma cells; the effect of IL-6 on cell migration and invasion may be mediated through regulation of the expression of MMP-2 and MMP-9., Icaritin suppresses the proliferation of SaOS2 human osteosarcoma cells by increasing apoptosis and downregulating MMP2/9 expression., Heterogeneity among serum MMP-2 and MMP-9 isoforms and their charge variants was found in sera of multiple sclerosis patients., The variant alleles of MMP2 -735C/T and MMP2 -1306C/T can be considered as molecular risk factors for B-NHL among Egyptians., Mutation in the matrix metalloproteinase 2 gene is associated with Torg Syndrome., Activation of Toll-like receptor-9 promotes cellular migration via up-regulating MMP-2 expression in oral squamous cell carcinoma., In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis., Evaluation of the microvessel density and the expression of MMP2 and MMP9 and TTF1 in the different subtypes of lung adenocarcinoma in Tunisia, MMP-2, MMP-9, and E-cadherin are expressed in the endometrium of infertile patients during the receptive phase of the natural menstrual cycle. However, there is no correlation between the expression of these molecules and the clinical IVF outcomes., we conclude that SOX2 promotes migration and invasion of laryngeal cancer cells by inducing MMP-2 via the PI3K/Akt/mTOR pathway, Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB., Spearman's rank tests showed that MMP-2/9 activities in cardiac tissue obtained before CPB were positively correlated with postoperative cTnT serum levels, This co-targeting strategy relies on the interaction of MMP-2 with integrin a(v)b(3), which are known to associate via the hemopexin domain of MMP-2, The possible role of MMP-9 and MMP-2 on the expression of soluble CD154 (sCD154) and membrane-bound isoform of the CD154 in Iranian multiple sclerosis patients, was examined., Poly(I, That expressed considerable amount of MMP-2 and MMP-9., probe activation for a MMP-2/9 responsive radiolabeled ACPP probe occurred already in the vasculature early after systemic administration, followed by nonspecific uptake in subcutaneous tumors that is comparable for high and low MMP-expressing tumors, Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas, Comparison of proMMP-2 and prognostic factors revealed a statistically significant correlation between proMMP-2 and age in patients with histologic grade I tumors for invasive ductal breast cancer., By reducing MMP-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways., expression of stromal MMP-2 alone, as well as coexpression of stromal MMP-2 with tumoural MMP-2 or -9, correlates significantly with prognostic predictors in breast cancer patients, data suggested that cellular cholesterol regulated ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell., expression of MMP-2 and MMP-9 proteins increased with the degree of extra-gastrointestinal stromal tumor metastasis risk., CGP may inhibit migration and invasion in HT1080 cells through the urokinase plasminogen activator (uPA)-uPA receptor signaling pathways to inhibit MMP-2 and MMP-9., MMP-2 gene expression was significantly increased in the secondhand smoke and active smoking groups, Study shows that beta3GnT8 is involved in the regulation of CD147 N-glycosylation and further influences MMP-2 expression in tumor cells suggesting that it may play an important role in the CD147 signaling as an upstream modulator of MMP-2 in tumor cells., local levels of MMP-2, an important factor for AAA development, were increased in current smoking AAA patients., Our results suggest that MMP-2 expression may contribute to the distinct invasive patterns seen in squamous cell and basal cell skin neoplasms., upregulation of MMP-2 and MMP-9 and downregulation of TIMP-1, is one of the mechanisms by which Skp2 promotes cell invasion of human renal cancer cells, The extracellular domain of soluble CD147 enhances the secretion of MMP-2 from hepatocellular carcinoma cells., MMP-2 -1306C>T polymorphism is not associated with breast cancer susceptibility., MMP2 polymorphisms are associated with colorectal cancer susceptibility., UV radiation emitted by the solar simulator was able to stimulate the cells from extracellular matrix in in vitro culture to TGF-beta production, MMP-2 and MMP-9 expressions and their mRNAs., Letter, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experiments., naringenin is capable of inhibiting bladder cancer cell migration through the downregulation of the AKT and MMP2 pathways, The MMP-2 levels in the fertilized oocyte group(208.2 +/- 31.6 ng/mL) were higher than those in the nonfertilized oocyte group, our finding suggests that both MMP-2 and MMP-9 expressed by synoviocytes as well as certain infiltrating immune cells role figure importantly in the angiogenesis in rheumatoid arthritis progression., Spinal cord injury patients who were physically active had lower plasma levels of MMP2., MMP-2 degraded Titin fragment in serum is related to induction of skeletal muscle atrophy., Overexpression of MMP2 is associated with ameloblastoma., Serum matrix metallopeptidase 2 was identified as relevant baseline biomarker of Sunitinib activity in advanced Renal Cell Carcinoma., Data indicate that the mRNA and protein expressions of extracellular signal-regulated kinase 1/2 (ERK1/2) and and matrix metalloproteinases MMP-2 and MMP-9 were significantly decreased by baicalein., MMP-2 level was significantly lower in patients with bone tumors than in controls., STAT3 and MMP-2 have a role in the diagnosis of colon adenocarcinoma and the detection of the degree of differentiation, a-Solanine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), High MMP2 protein expression is associated with pancreatic ductal adenocarcinoma., PPARdelta-mediated modulation of MMP-2 secretion and elastin expression may contribute to the maintenance of skin integrity by inhibiting ROS generation, Ectopic expression of MMP2 rescued miR-130b-suppressed cell migration and invasion., The present study suggested EGCG at nontoxic levels could inhibit migration of melanoma cells via downregulation of activities of secreted MMP-2 through the inhibition of the ERK1/2 phosphorylation, Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation., The results indicated that SNS and EGCG caused a dose-dependent decline in the activity, transcription and translation of MMP-2 after treatment with SNS and EGCG, while AA was only able to inhibit the activity at maximum doses, HP1b negatively regulates MMP2 expression in a transcriptional level and prevents MMP2 activation through reducing the expression of MT1MMP., Taken together, our findings suggest that AEG-1 plays a crucial role in the aggressiveness of osteosarcoma via the JNK/c-Jun/MMP-2 pathway., fibronectin was able to induce MMP2 expression by 30% decrease in its promoter methylation, EGF aids in the production of MMP-2, which favors the dissolution of the basement membrane, contributing to cell migration and tumor progression., found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression, Data suggest that intracellular S100A8/A9 contributes to the cancer cell phenotype by modulating matrix metallopeptidase 2 (MMP-2) expression and activity to regulate cell migration and mobility., G-CSF increases MMP-2 activity and VEGF secretion in Swan 71 cells (trophoblasts) through activation of PI3K/Akt and Erk signaling pathways., upregulation of MMP2 rescued the decreased migration and invasion induced by the knockdown of Rock2, whereas the knockdown of MMP2 decreased Rock2-enhanced hepatocellular carcinoma migration and invasion, The authors' results support the importance of MMPs and their tissue inhibitors in meningioma pathogenesis., The roles of MMP-2 in cardiac injury and repair. [Review], the proliferation of HBSMCs induced by stretch was resulted from the stretch-induced MMPs expression and release., These results suggested that PFIO could suppress the invasion and migration of human lung carcinoma by reducing the expression levels and activity of MMP-2 and MMP-9 via suppression of MAPKs, PI3K/AKT, and NF-kappaB signaling pathways., Data indicate matrix metalloproteinase 2 (MMP2) homozygous missense mutation in exon 8 c.1228G>C (p.G410R)., TIMP-2 -418 GC + CC and MMP-2 -1575GA/-1306CC genotypes could be genetic predisposing factors for moyamoya development., MMP-2, MMP-9, MMP-7 and TIMP-2 were upregulated in primary spontaneous pneumothorax lesions., In cases of preeclampsia, the least expression of MMP-2 and MMP-9 is recorded in IC and MGCs in the complete absence of intravascular cytotrophoblast, MMP-2 expression correlates with tumor thickness in melanoma and is an independent predictive factor for lymph node involvement., High serum and tissue levels of MMP2 were associated with lymph node metastasis and tumor staging in breast cancer., LOX may play a role in the metastasis of non-small cell lung cancer by promoting MMP2/MMP9 expression., MMP-2 is increased and TIMP-1 decreased in thoracic aortic aneurysms with bicuspid aortic valve., The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation., resistin promotes chondrosarcoma metastasis and MMP-2 expression through activation of the AMPK/p38 signaling pathway and down-regulation of miR-519d expression, we concluded that NCTD enhances TIMP2 antitumor and antiVM activities in gallbladder cancers through downregulating MMP2 and MT1MMP., Stat3, phosphorylated Stat3, and MMP2 were overexpressed in esophageal squamous cell carcinoma (ESCC) and associated with invasion of ESCC. Stat3 up-regulated expression of MMP2 in ESCC through directly binding to the MMP2 promoter., The MMP-2/TIMP-2 expression ratio has a higher prognostic value than the separate expressions of MMP-2 and TIMP-2., MMP-2, MMP-9, TIMP-1, and TIMP-2 may have important roles in the development and progression of MFH., VEGF-alpha, MMP-2 and MMP-9 may play a role in colorectal tumorigenesis, Results demonstrated that the p38 MAP kinase signaling pathway is essential for MMP-9 but not MMP-2 upregulation in pericytes in response to TGF-beta1 stimulation, MMP-2 polarizes T cells toward type 2 responses in vivo, in a TLR2-dependent manner., a possible coordinated role of VEGF-A and MMP-2 during uterine leiomyomas growth and angiogenesis with potential prognostic significance, MMP-2 -1306C>T polymorphism is associated with primary ovarian insufficiency in Korean women. Lower serum E2 levels were detected in healthy women with the MMP-2 -1575GA+AA/MMP-2 -1306CT+TT and MMP-2 -1306CT+TT/MMP-9 2678GG combination genotypes., Cleaved CD147 plays a pivotal role in stimulating fibroblasts to induce Matrix Metalloproteinase 2 activity., Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak2 and Stat3 pathway, Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9, we found that miR-373 and -520c down-regulated the activities of MMP2 in various cancer cell lines but simultaneously up-regulated the expression of MMP9 gene only in HT1080 cells, In prostate cancer cells, alphavBeta6 is required for upregulation of MMP2., Upregulation of EZH2, MMP2 and TIMP2 expression was correlated with metastasis of RCC to bone tissues ex vivo and in vitro., MMP-2 is necessary for fibronectin matrix disruption and dispersal of human fibroblast cell clusters., WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential., the most significant MMP-2...fTHP-5 interactions at the catalytic and noncatalytic domains are also analyzed to gather some clues about the role of the different domains during collagenolysis., Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of MMP-2 and subsequent metastatic ability in human osteosarcomas., Cyclic stretch significantly induced ESC secretion of CXCL8 and CXCL1 and neutrophil chemotaxis. Stretch also increased MMP-1, MMP-2, and MMP-3 activity, activin A secretion, and activity in ESC., High MMP2 expression is associated with lung cancer., IHC staining showed higher TR4 level, more macrophage infiltration, lower TIMP-1 and stronger MMP2/MMP9 in tumor tissues., Ara-C enhances the invasiveness of gastric cancer cells by expression of CD-147 /MMP-2 and MMP-9 via the ERK signaling pathway., these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases, Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2., Increased Pak4 expression can lead to development of adenomyosis by enhancing the invasiveness of endometrial cells through regulation of MMP-2 and -9 activities., inhibiting heat shock transcription factor 1, which links temperature and peripheral clock-gene oscillations, inhibited MMP-9 but not MMP-2 temperature-driven MMP cycling., Our results suggest that the presence of the variant allele in the promoter of MMP-2 or TIMP-2 may be a protective factor for the development of breast cancer., The expression level of GOLPH3 is correlated with metastasis and prognosis in NSCLC, and GOLPH3 mediates metastasis by regulating the protein levels of MMP-2 and MMP-9 in vitro., TIMP1 downregulates MMP-2 activity and inhibits the degradation of occluding in Caco-2 intestinal cells, Data suggest that changes in DNA methylation in trophoblasts regulate (1) cell mobility/placentation, (2) expression of claudin-4 (CLDN4) and 4-fucosyltransferase (FUT4), and (3) matrix metalloproteinase (MMP2 and MMP9) activity., Data indicate that the enzymatic activity of MMP-2 and MMP-9 on dystroglycan plays a significant role in muscular dystrophies and also in physiological processes taking place in the central and peripheral nervous system. [review], ENaC could mediate trophoblast cells invasion ability through regulating expression and activity of matrix metalloproteinase-2., AR knockdown led to substantial reductions in matrix metalloproteinase 2 (MMP2) and p-AKT levels in Esophageal squamous cell carcinoma cell lines, but no significant change in AKT and MMP9 expression, High MMP2 expression is associated with invasion and promotion of metastasis in melanoma., MMP-2 -735 C allele is a risk factor for breast cancer., Matrix metalloproteinase-2 -1306 C>T gene polymorphism is associated with reduced risk of cancer., To examine the relationships among BAG3, miR-29b and MMP2 in endometrioid adenocarcinoma cells., High serum mmp2 levels are associated with Squamous cell carcinoma., Reactive oxygen species increase the activity/levels of gelatinolytic matrix metalloproteinases, and stimulate cytokine secretion in human periodontal ligament fibroblast., MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA., our findings suggested that the differential expression of MMP-2 and TFPI-2 have a negative correlation in pancreatic carcinoma, japonicus was able to inhibit the expression of MMP-2 and MMP-9 and suppress the transcription and translocation of iNOS and COX-2 by directly inhibiting the activation of NF-kappaB and the phosphorylation of the MAPK pathway, There was no association between the expression of metallopeptidase-2 or tissue inhibitor of metalloprotease 2 and death or progression, MMP-2 is a direct target of miR-519d-3p., A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M., MMP-2 protein and ECM1 gene are useful preoperative markers for defining malignancy in suspicious thyroid nodules, Results showed that expression of MMP-2 was associated with poor survival and lymph node metastasis. [meta-analysis], western blot analysis showed that ophiopogonin-D inhibited the expression and secretion of matrix metalloproteinase-9 (MMP-9), but not that of MMP-2., For gingiva samples from chronic periodontitis patients treated with antibiotics, MMP-2 positive reaction was restricted to deep epithelial layers and few cells of the connective tissue. No significant difference was observed for TIMP-2 expression., Neutralization of MMP activity by antibodies to MMP2/9, broad-spectrum MMP inhibitor or selective gelatinase inhibitor resulted in significant suppression of HGF-induced EMT and cell migration/invasion., D90 significantly inhibited the invasion and metastasis of OSCC cells by decreasing the expression of sp1 and increasing the expression of RECK to suppress the expression and activity of MMP-2 and MMP-9., recombinant human (rh) MMP-2 and MMP-9 were incubated with Abeta40 and Abeta42, and the resulting proteolytic fragments were assessed via immunoprecipitation and quantitative mass spectrometry, Results show that low levels of MMP-2 expression in gastric tumor and stromal compartments were significantly associated with poor prognosis., MMP2 -1306 TT carriers had a decreased incidence of esophageal cancer., Results indicate that VEGFR2 -906, COX-2 -1195 and MMP-2 -1306 variants and their combinations may signi fi cantly in fl uence clinical outcome in inoperable non-small cell lung cancer patients treated with radiotherapy with or without chemotherapy., EFEMP1 might indirectly enhance the expression of MMP-2, providing a potential explanation for the role of AEG-1 in metastasis. NF-kappaB pathways might be one of the effective ways which EFEMP1 was induced by AEG-1., type 2 diabetes (T2DM) patients carrying the T allele of MMP-2 C(-1306)T polymorphism have a significantly reduced risk of cardiovascular disease; the C(-1306)T polymorphism is associated with susceptibility to stroke in T2DM patients, PinX1 negatively regulated ccRCC metastasis and the expression of MMP-2 and NF-kappaB-p65, High MMP2 expression is associated with renal fibrosis in lupus nephritis., both populations exert distinct proteolytic activities, being the IL-10-stimulated macrophages the most efficient in inducing matrix metalloprotease (MMP)-2 and MMP-9 activities., PM10 from commercial zone up-regulated the activity of metalloproteases MMP-2 and MMP-9 and disrupted E-cadherin/beta-catenin expression after 48 h of exposure., data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including macrophages, Tissue array analysis suggests role for MMP2 in regulating the occurrence of glioma and disease progression., Results demonstrate that miR-29b serves as a tumor metastasis suppressor, which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression., In asthma, MMP-1 and MMP-2 mediate IL-13-induced suppression of ELN expression in airway fibroblasts., MMP2 was correlated with diastolic dysfunction in new-onset heart failure outpatients., Lipid raft-associated processes, such as PP2A and MMP-2 activation, participate in PCB153-induced disruption of occludin function in brain endothelial barrier., results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha, Both MMP9 rs3918242 and MMP2 rs243865 are associated with risk of NAFLD., MMP-2 expression was higher in retinoblastoma than in normal retina; undifferentiated tissues had higher positive expression than differentiated tissues (not statistically significant); higher positive expression was detected in invasive optic nerves., According to this work it seems likely that product release is the rate-limiting step in MMP-2 catalysis., Treatment with propofol efficiently reduced MMP2 protein expression levels, and overexpression of miR218 also decreased MMP2 protein expression levels., SFN inhibited invasion by activating ERK1/2 to upregulate E-cadherin and downregulate CD44v6, thereby reducing MMP-2 expression and activity. E-cadherin is an invasion inhibitor, while CD44v6 and MMP-2 are invasion promoters, MMP2 mRNA is degraded in pancreatic tumor cells following treatment with PP2A inhibitors., The results suggest that AQP1 may facilitate lung cancer cell proliferation and migration in an MMP-2 and-9-dependent manner., The findings of this study suggested that the MMP-2-1306 T/C polymorphism is a direct risk factor for ischemic leukoaraiosis., MMP-2 plays an essential role in leptin-induced migration and invasion. Leptin increased the mRNA and protein expression and enzyme activity of MMP-2 in 11Z and 12Z endometriotic cells by an ObR-dependent JAK2/STAT3 signaling pathway., Metformin suppressed OS MG63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (MMP2) and MMP9, the results showed that Dicer protein ablation leads to increased cell invasion, higher levels of matrix metalloproteinase-2, and decreased levels of key miRNAs shown to inhibit invasion, we report the novel concept that miR-20b exerts a suppressive effect on both cell cycle-modulated proliferation and MMP-2-mediated migration and invasion in bladder cancer EJ cells., These results indicate that our hydrophilic extract from P. oceanica might be a source of new pharmacological natural products for treatment or prevention of several diseases related to an altered MMP-2 and MMP-9 expression., E6-HPV16/E7-HPV16 promoted the activity of MT1-MMP and MMP-2/9, contributing to the migration of cervical cells and neoplasm invasiveness., A positive association for VEGF-D and an inverse association for MMP-2 were observed in patients with positive lymph node status at the time of radical cystectomy in urothelial carcinoma of the bladder., Plasma MMP-2 level may be a useful diagnostic marker for monitoring hepatic fibrogenesis in patients with disease of different aetiologies., WM130 could inhibit cell proliferation, invasion, migration and induced apoptosis in HCC cells by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways., Findings suggested that MMP-9 and MMP-2 overexpression might indicate a higher risk of poor prognosis in breast cancer. [meta-analysis], This study demonstrated that the MMP-2 -1575G/A polymorphism led to a 5-year-earlier age of disease onset in MS patients with ON as a first symptom (p=0.009)., PPARgamma activation can activate PTEN expression, thereby suppressing the expression of MMP2 and hence inhibiting the invasion and metastasis of pancreatic cancer cells., For the MMP2 -1306 C/T polymorphism, there was a negative association with the T allele for bladder cancer in the Asian population, In summary, our results showed that negative HCRP-1 expression is an independent prognostic factor for RCC patients., Data suggest that activin A up-regulates SNAIL expression via ALK4/ACVR1B-induced SMAD signaling in trophoblast cells; elevated SNAIL contributes to up-regulation of MMP2 expression which plays key role in promoting trophoblast cell invasion., Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications., There is no significant difference between different genotypes of matrix metalloproteinase 2 polymorphism and risk of developing Prostate Cancer, The level of MMP-2 in follicular fluid was a reliable marker of oocyte maturation in in vitro fertilization., two distinct MMP-2 isoforms are associated with tubular injury in delayed kidney graft function, Data show that higher plasma levels of matrixmetalloproteinases 2/9 (MMP-2/MMP-9), osteopontin (OPN) and interleukin-6 (IL-6) were observed in Non-Hodgkin lymphomas (NHL) patients compared to controls., The inhibitory effect of nuclear HDAC6 on invasion of NSCLC was mediated by the deacetylation of the p65 subunit of nuclear factor-kappaB, which decreased its DNA-binding activity to the MMP2 promoter, leading to the downregulation of MMP2 expression., An important role of MMP2 in connective tissue remodeling (proteolytic degradation) during the early period of postinfarction reparative regeneration., The highest number of strong immunoreactivity to MMP-2 in the ameloblast region was found in the plexiform variant., Intensive vascular networks formed by HUVECs were associated with hAMSCs or BMMSCs and related to MMP2 and MMP9., PKD2 is a core factor in the formation of this multiprotein complex at the TGN that controls constitutive secretion of matrix metalloproteinase cargo., Data show that evodiamine significantly decreased mRNA and protein levels of matrix metallopeptidase 2 (MMP-2) in the nasopharyngeal carcinoma (NPC) cells, but had little effects on matrix metallopeptidase 9 (MMP-9) mRNA and protein levels., data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB-dependent upregulation of MMP-9 and MMP-2, showed a significant association between the variants of MMP-2 and TIMP-2 promoters and spontaneous intracerebral hemorrhage, the serum levels of MMP-2 and MMP-9 proteins were higher in patients with OA than in controls, while MMP-1 and MMP-9 protein expressions were higher in the synovial joint fluid of patients with osteoarthritis than in controls., This study showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of cardiovascular diseases (CVDs) suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs., targeting EGFR signaling and its downstream molecules contributed to the inhibition of EGFinduced HT29 cell metastasis caused by tetrandrine, eventually leading to a reduction in the mRNA and gelatinase activities of MMP-2 and MMP-9, The blocking of either intracellular ROS or ERK pathway caused the downregulation of MMP-9 and MMP-2 expression., Expression of MMP2 and MMP7 in gastric cancer is not associated with mTOR, MMP9 expression might be related to mTOR signalling in a subset of tumors, The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9., Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells., MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population., The abundance of mutated STIM1 and the MMP-2 expression were higher in native human umbilical vein endothelial cells of patients with gestational hypertension than controls and were significantly correlated with blood pressure., renal cell carcinoma patients with a high MMP-2 expression level exhibit rapid progression of renal cell carcinoma and that high MMP-2 expression level is associated with poor prognosis, TIMP3 was validated as a direct target of miRNA-21 by dual-luciferase reporter assay. Silencing with small interfering RNA against TIMP3 promoted angiogenesis and increased MMP2 and MMP9 expression at the protein level., determined normal concentration ranges for MMP-1, MMP-2, MMP-9, TIMP-1, and ratios of concentrations of MMPs and TIMP-1 (MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-9/TIMP-1) in the amniotic fluid at the first period of labor in physiological pregnancy., The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 and MMP-9 and in some cases the enhanced activity of uPA and ACE, which makes an additional contribution to the increased invasive potential of tumor, MMP2 variants are associated with rheumatoid arthritis in women., Data show that spider venom sphingomyelinase D increased expression/secretion of MMP2, MMP9 and MMP7 which was associated with keratinocyte cell death., Overexpression of MMP2 and EGFR were independent risk factors for mortality in non-small cell lung cancer patients.,
OFFICIAL_GENE_SYMBOL MMP2,
OMIM_DISEASE Multicentric osteolysis, nodulosis, and arthropathy,
SP_COMMENT catalytic activity:Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 4 calcium ions per subunit., disease:Defects in MMP2 are the cause of Torg-Winchester syndrome [MIM:259600]; also called multicentric osteolysis nodulosis and arthropathy (MONA). Torg-Winchester syndrome is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5)., function:In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond., PTM:The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3)., similarity:Belongs to the peptidase M10A family., similarity:Contains 3 fibronectin type-II domains., similarity:Contains 4 hemopexin-like domains., subunit:Ligand for integrin alpha-V/beta-3., tissue specificity:Produced by normal skin fibroblasts.,
syndecan 1(SDC1) syndecan 1(SDC1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2p24.1,
ENSEMBL_GENE_ID ENSG00000115884,
GENERIF_SUMMARY The loss of syndecan-1 expression evident in acantholytic conditions, mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma, Serum levels of soluble syndecan-1 correlated with tumor mass in patients with multiple myeloma., Soluble syndecan-1 promotes growth and dissemination of transplanted human myeloma tumors in vivo in SCID mice implanted with human bones., review of structure, function, cell and tissue distribution, regulation of expression in isoform specific manner by farnesoid X receptor, Cells adherent via syndecan-1 do not spread, but can be induced to spread by Mn(2+), suggesting that activation of a beta(1) or beta(3) integrin partner is required., TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression, High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype, shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration, The increased stromal syndecan-1 expression, coupled with its loss from the surface of carcinoma cells, may contribute to tumor cell invasion and the development of metastases, results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1, the extracellular domain mediates an interaction that is necessary for dynamic cytoskeletal rearrangements whereas an interaction of the transmembrane domain is required for the initial spreading response, results demonstrate that cell-surface syndecan-1 is a degradative target of heparanase (HPSE-1), and syndecan-1 regulates HPSE-1 biological activity, serves as a primary human papillomavirus receptor protein in natural HPV11 infection of keratinocytes., MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface, Growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1., Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases., in hyperinflammatory lesions, ephrinB2 was predominantly expressed in macrophage-like cells and EphB4 in small venules; syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells after stimulation with preclustered ephrinB2, syndecan-1 and glypican-1 have roles in progression of ovarian cancer, Altered matrix-dependent signaling due to increased levels of cell surface syndecan-1 may lead to epithelial cell invasion during early stages of tumorigenesis., Concomitant expression of syndecan-1 in both epithelium and stroma may be a predictor of unfavourable prognosis in breast cancer, and in contrast with previous studies, loss of epithelial syndecan-1 was associated with a more favourable prognosis, syndecan-1 is likely to be a critical regulator of many cellular behaviors that depend on activated alpha(v)beta(3) integrins, constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis lipopolysaccharide, osteoprotegerin affects monocyte mi-gration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1., syndecan-1 has a role in progression of invasive breast carcinomas through the remodeling of breast cancer tissue via interaction with other extracellular matrix components, Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC., Stromal syndecan-1 expression is an independent prognostic marker in pancreatic cancer, whereas epithelial syndecan-1 expression predicts better prognosis only in resectable disease., Loss of syndecan-1 plays a role in the growth of G-type cancers of differentiated type gastric cancers at an early stage, Low epithelial syndecan-1 expression was associated with a higher histological grade and a more advanced clinical stage of the colorectal cancer, Malignant glioma cells express all types of syndecans. NF-kappaB participates in the upregulation of the syndecan-1 expression at the transcriptional level, and increased expression of syndecan-1 could associate with thrombospondin-1., stromal fibroblast-derived Sdc1 stimulates breast carcinoma growth and angiogenesis in vivo, shed syndecan-1 or MMP7-syndecan-1 complexes may have roles in tumor progression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, The ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity., Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage immunoproliferative small intestinal disease (IPSID)., CD138 may have a role in progression of nodal diffuse large B cell lymphoma, syndecan-1 may have a role in progression of B-cell chronic lymphocytic leukemia, increase of Syndecan-1 in all tissue compartments and a redistribution from epithelium to stroma may be a characteristic feature for dense breast tissue, syndecan-1 shedding may modulate the pathogenesis of specific microbes, the endocytic path taken by Syn-1 is clathrin-independent and relies upon lipid raft function, Lacritin targets the deglycanated core protein of SDC1 and not HS chains or SDC2 or SDC4. Binding requires partial or complete removal of HS chains by endogenous HPSE. This limits lacritin activity to HPSE release sites as an HPSE 'off/on switch'., Syndecan-1 expression is uniquely influenced by changes in the phase and magnitude of the local stress field., domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility, Heparanase influences expression and shedding of syndecan-1, In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas., Decreased syndecan-1 is asociated with thyroid cancer, upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability, SDC1 interaction with the LG4/5 domain in kalinin is essential for keratinocyte migration., syndecan-1 regulates keratinocyte proliferation differently during skin development and in healing wounds., Results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix., heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal epithelial barrier function., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., aberrant skin expression may be involved in the development of psoriasis, n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate SDC1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect., In vitro reconstructed normal human epidermis expresses differentiation-related proteoglycans (CD44, syndecan-1, desmosealin, and 7C1)., syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma, loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas, Our findings thus suggest that a previously unknown link between integrin alpha2beta1 and syndecan-1 is important in regulating cell adhesion to collagen and in triggering integrin downstream signalling., CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C., Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms., Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma., Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation., syndecan-1 directly contributes to the growth and invasive ability of oral cancer cells, Plasma levels of syndecan-1 increased significantly during coronary artery bypass grafting, with or without the use of cardiopulmonary bypass., Oxidative shedding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that may contribute to pulmonary fibrosis., Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies., Data show that syntenin-1 binds to syndecan-1 and participates in the formation of membrane protrusions, and that syntenin-1 recruitment depends on the dephosphorylation of Tyr-309 located within syndecan-1 PDZ binding domain EFYA., Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Results show that heparanase alters the level of nuclear syndecan-1., The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in ameloblastic carcinomas is in accordance with its higher aggressiveness as compared to the rare desmoplastic and peripheral ameloblastomas., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., syndecan-1 is a co-receptor for APRIL and TACI at the cell surface of MMC, promoting the activation of an APRIL/TACI pathway that induces survival and proliferation in multiple myeloma cells, Results showed that epithelial syndecan-1 expression is reduced as lip carcinogenesis progresses (normal tissue>actinic cheilitis>lip squamous cell carinoma), suggesting that syndecan-1 could be a useful marker of malignant transformation in the lip., Ressutls show that cystic tumors of the pancreas express syndecan-1 and tenascin differently and suggest that low syndecan-1 expression might serve as a predictive factor for malignancy., the effects of syndecan-1 on myeloma survival, growth, and dissemination are due, at least in part, to its positive regulation of tumor-host interactions that generate an environment capable of sustaining robust tumor growth., Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Chronic inflammation and exogenous insulin usage increases the serum syndecan-1 level in type 2 diabetics., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., syndecan-1 might contribute to urothelial carcinoma cell survival and progression, higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus, ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., Sdc1 has a protective effect during experimental colitis., High CD138 serum levels are associated with B-chronic lymphocytic leukemia progression., Data substantiate the existence of a co-adhesion receptor system in tumor cells, whereby Sdc1 functions as a key regulator of cell motility and cell invasion by modulating RhoA and Rac activity., Age-associated study of detailed characterization of circulating CD138-negative and CD138-positive plasma cells sorted by flow cytometry shows a typical plasma cell cytology with no obvious morphological differences., all syndecans can interact with proteins of the actin-associated cytoskeleton--REVIEW, pathway driven by heparanase expression in myeloma cells, Decreased expression of Syndecan-1 mRNA and the increased expression of HPA-1 mRNA can promote the invasion and metastasis of colorectal cancer., Syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction., Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., The presence of a less mature, more resistant CD138-negative myeloma cell fraction within bone marrow microniches might contribute to high incidence of relapse of myeloma patients., Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Expression of syndecan 1 in healthy breast tissue during menstrual cycle., Results suggest a role for syndecan-1 and cathepsins D and K in growth and invasiveness of esophageal squamous cell carcinoma., This study confirms a direct relationship between suprabasal p35 localization together with down-regulation of syndecan-1 immunoexpression and dysplastic changes of oral lichen planus and hence the possibility for malignant transformation., The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma., The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., multiple regression analysis showed that apolipoprotein A1 was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes, A threshold of greater than six CD138+ metabolically active plasma cells is associated with poor kidney allograft function and survival., Loss of SDC-1 is associated with prostate cancer., couples the insulin-like growth factor-1 receptor to inside-out integrin activation, These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis, High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells., In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation. In prostate cancer samples syndecan 1 was expressed to granular-cytoplasmic localisation., sCD138 may be applicable as a surrogate marker of disease activity., A multiple regression analysis showed that BMI (beta = 0.783, P < 0.000) was a significant predictor of positive syndecan-1 neutrophils in subjects with type 2 diabetes., Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding and prevents from its subsequent induction of fibroblast proliferation., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., Syndecan-1 is up-regulated in BeWo cells during differentiation and its silencing inhibits syncytialization., CD138 may contribute to the differential diagnosis of renal tumors, syndecan-1 regulates mesenchymal tumor cell adhesion and migration, and different domains have differential effects., Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype, In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality., These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity., Syndecan-1 mediates hepatic VLDL turnover in humans as well as in mice and shedding might contribute to hypertriglyceridemia in patients with sepsis., a new role for syndecan-1 in HSV-1 pathogenesis, results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., We found increased vascular adhesion protein 1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock, Syndecan-1 expression was increased in tubular epithelial cells in allografts. Increased syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy and prolonged graft survival., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Heparan sulfate chains of syndecan-1 regulate ectodomain shedding., Our results demonstrate that syndecan plays a negative role in death receptor-mediated cell death, CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Placental syndecan-1 expression is associated with premature birth and fetal growth., syndecan-1 is a novel target of the oncomiR miR-10b., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., Data indicate that immune-magnetic CD138-positive cell sorting significantly increased the percentage of abnormal cells identified in FISH analysis of multiple myeloma (MM) samples., study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness, the increased expression of syndecan-1 at gene and protein levels is correlated with advanced tumor progression and poor outcome in patients with glioma. Syndecan-1 might serve as a potential prognosis predictor of this dismal tumor., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., observations suggest that low CD138 expression in multiple myeloma cells relates to poor prognosis, immature phenotype and low sensitivity to lenalidomide, Syndecan-1 alters the dynamic exchange of adhesion complex proteins, which in turn regulates migration speed., Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration, the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain., Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases., findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells, Data indicate that Syndecan-1 silencing had less powerful effect on the transcriptome compared to overexpression., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., The DNA methylome of CD138-positive cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanced stages of myeloma, as well as healthy controls, is characterized., SDC1 expression was not different in patients with advanced vs no/limited LBD.A significant positive correlation between gene expression & BM plasma protein levels was observed for SDC1., Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., Elevation of serum SDC1 is associated with Crohn's disease., The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating keratoacanthoma and squamous cell carcinoma, Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., SDC1 expression is associated with N stage and the status of resection margin involvement in squamous cell carcinoma (SCC) of the tonsil., High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis., Our studies demonstrates that SDC1 is the major receptor protein for HCV attachment., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, Through phenotype analysis, non-HAV-specific antibody-secreting cells are found to be Ki-67lowCD138highCD31highCD38high compared with HAV-specific ASCs., Comparative characteristics of the structure and function for syndecan-1 from animal organisms, Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data indicate that biochemical markers significantly associated with mesothelioma were hyaluronan, N-ERC/mesothelin and syndecan-1., Data indicate that the CD138int follicular B cells were clearly distinct from plasma cells., Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer., Chemotherapy stimulates syndecan-1 shedding, placental expression decreased in pre-eclampsia, independent of labor, gestational age, birthweight centile, SD1 mRNA levels do not differ between resected colon samples of patients with acute colonic diverticulites and ileocolonic Crohn's disease., Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells., Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways, It is concluded that increased SNAIL levels in advanced PC are associated with low expression of syndecan 1, Urinary levels and cellular localization of syndecan-1 are associated with differentiation status of patients with bladder cancer., Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells., Presence of SDC1 in tumor stroma is an independent risk factor for patient survival in bladder cancer, this study revealed a link between miRNA-143 and Syn-1 in the pathogenesis of melanoma., Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection., Expression decreased with the decreasing grades of dysplasia. Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., HO-1, S100A4, and SYND1 expressions have prognostic value in primary non-muscle-invasive bladder cancer (NMIBC)., Syndecan 1 mRNA expression did not vary between chronic diverticulitis and Crohn's disease., In DCIS of different nuclear grades, tissue localization of syndecan-1 is significantly divergent, suggesting a specific effect on biology and progression of DCIS., Increased syndecan-1 expression levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis of malignant gastric cardiac adenocarcinoma., Elevated levels of soluble CD138/Sdc-1 in older bladder cancer patients and those with muscular invasion sheds some light on the mechanisms of the disease invasion., Syndecan-1 is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts., syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma., syndecan-1(+) cell syncytia and excess GAG production recapitulate elements of the invertebrate encapsulation reaction, itself dependent on insect transglutaminase and glutaminated early response proteins, Sdc1 is required for HER2-mediated activation of the alpha6beta4 integrin in wound healing assays or tumor cell survival., PKC-mediated syndecan-1 downregulation causes loss of cell invasiveness in melanoma cells under anchorage independency, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., syndecan-1 may have a role as a biological and prognostic marker in patients with triple-positive breast carcinomas, The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes, High Syndecan-1 expression is associated with chemotherapy resistance in colorectal cancer., High expression of SDC1 is associated with dedifferentiated liposarcoma tumorigenesis., Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM., A significant association between SDC1 and breast cancer was identified., this work has broad implications beyond myeloma because shed syndecan-1 is present in high levels in many tumor types as well as in other disease states., Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer, Serum SDC-1 levels are increased in systemic lupus erythematosus patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN., Syndecan-1 expression is associated with tumor size and EGFR expression in colorectal carcinoma, This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation., our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans, syndecan-1 has a role in glycocalyx shedding and is increased in patients with end-stage liver disease; ischemia-reperfusion injury during OLT further exacerbates glycocalyx shedding, Sdc-1 may act as a modulator of ESC apoptosis and probably invasion depth as a crucial factor for successful pregnancy., The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality., Elevated plasma syndecan-1 levels in renal transplantation patients might be interpreted as repair/survival factor related to loss of tubular and endothelial function in transplanted kidneys., Despite presence of the HPV-receptor syndecan-1 in tongue squamous cell carcinoma (TSCC), HPV prefers the tonsillar environment., miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1., SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma., HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts., stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma, miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation., The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients., Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis., The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment., The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.,
SP_COMMENT function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix., similarity:Belongs to the syndecan proteoglycan family., subunit:Interacts with CDCP1.,
vitronectin(VTN) vitronectin(VTN) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q11,
ENSEMBL_GENE_ID ENSG00000109072,
GENERIF_SUMMARY studies reveal that vitronectin associates with fibrin during coagulation, and may thereby modulate hemostasis and inflammation, uPA-dependent VSMC adhesion is a function of selective Vn phosphorylation by the ectoprotein kinase CK2, Mapped the fibrin binding sites in vitronectin, Plasminogen activator inhibitor type 1 promotes the self-association of vitronectin into complexes, Snake venom disintegrin, saxatilin, inhibits interaction of human umbilical vein cells to immobilized vitronectin and adhesion of smooth muscle cells to vitronectin as well as vitronectin-induced migration of the SMC cells., the rSMB domain of vitronectin is distinct from the crossed pattern present in most small disulfide bond-rich proteins, demonstrated that the avidity of heparin binding to vitronectin is governed by both the conformational state of the monomer and multimerization of the molecule, Adhesion of hairy cells to vitronectin inhibits interferon-alpha-induced apoptosis., REVIEW, strong vitronectin accumulation in extracellular matrix around some breast cancer cell clusters and in the subendothelial area of some blood vessels, importance of IGFBPs in modulating IGF-I binding to VN and that this binding has functional consequences in cells., Plasma vitronectin level potentially represents a pathogenic factor for atherogenesis and thrombus formation in patients with coronary artery disease., Results indicate that multimeric vitronectin in encapsulating peritoneal sclerosis (EPS)ascites plays a potential role in peritoneal fibrogenesis in EPS., Turnover of soluble vitronectin requires ligation of vitronectin's basic domain and that this binding event can work in trans to regulate vitronectin degradation., VN-potentiated platelet-clot interaction requires VN in the clot and multimeric VN bound to the platelet surface; self-assembly of VTN may provide a physiologically relevant contribution to platelet aggregation on a blood clot., Results describe the three-dimensional structure of an N-terminal fragment comprising the first 51 amino acids from human plasma vitronectin., Human mesenchymal stem cells cultured on purified vitronectin produce a mineralized matrix, and express osteopontin, osteocalcin, collagen I, and alkaline phosphatase., IGF-II, Structural model provides an indication of the disposition of the central domain and C-terminal heparin-binding domains of vitronectin with respect to the N-terminal somatomedin B domain., Through promoting Met-Integrin association, HGF-FN and HGF-VN complexes coordinated and enhanced endothelial cell migration through activation of the PI-3 kinase pathway involving a Ras-dependent mechanism, Vittronectin can enhance epidermal growth factor and basic fibroblast growth factor ) to enhance keratinocyte cell division., examination of the mechanism by which granzyme B cleaves vitronectin, Complexation wiwth serpin peptidase inibitor (PAI-1), with a sedimentation coefficient of 6.5 S, is the key intermediate for the assembly of higher order complexes., IGROV1 cells were shown to adhere rapidly on the HUVECs monolayer; adhesion was inhibited by anti-alphav integrin and anti-Vn blocking antibodies, but not by anti-beta1 integrin antibodies, Binding of vitronectin to outer membrane protein Haemophilus influenzae type b surface fibrils (Hsf) inhibits complement-mediated bactericidal activity and prevents complement-induced cell lysis., Osteogenesis on vitronectin correlated with enhanced focal adhesion formation, the activation of focal adhesion kinase (FAK) and paxillin, and the diminished activation of extracellular signal-regulated kinase (ERK)., PLAUR and the somatomedin B region of VTN direct the localization of UPA to focal adhesions in microvessel endothelial cells., Solution structure of recombinant somatomedin B domain from VN produced in Pichia pastoris is reported., vitronectin without the somatomedin B domain exhibits residual plasminogen activator inhibitor-1-binding activity, Vitronectin and growth factor complexes way have roles in wound healing, MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor., reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor, vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses, analysis of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain, ability of ovarian carcinoma cells to bind to peritoneal mesothelium in vitro and strongly suggest that vitronectin and its receptors contribute to this crucial event., pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., support the beneficial effect of VN on oligodendrocytic differentiation of human embryonic stem cells, These results support a model for PAI-1 binding to vitronectin in which the interaction surface extends beyond the region of PAI-1 occupied by the SMB domain., A vitronectin M381T polymorphism increases risk of hemangioblastoma in patients with VHL gene defect, Low levels of serum vitronectin is associated with febrile phase, hypotensive and oliguric phases in patients with hemorrhagic fever with renal syndrome., Vitronectin mediates a protective role at the bacterial surface by binding to nontypeable Haemophilus influenzae 3655 and reducing membrane attack complex (MAC)-induced hemolysis., Report differences in proteolytic processing of vitronectin and/or high molecular weight kininogen in women who develop preeclampsia., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., Here we show that vitronectin is the component of human serum driving stem cell differentiation through an integrin alpha V beta 3-dependent mechanism., Vitronectin may be an independent predictor of adverse cardiovascular outcomes following acute stenting in acute coronary syndromes., results suggest that in two metastatic cell lines integrin-linked N-oligosaccharides influence the VN adhesion receptor activity and function., expression of vitronectin at the periphery of mesothelial cells and within ovarian cancer cell clusters suggests a potential role for this molecule during intraperitoneal implantation of ovarian cancer cells, Data reveal that multimeric VTNC attenuate Cyr61 binding to immobilized VTNC, while monomeric VTNC was ineffective., This study directly reveals the binding mode between the N-terminal domain of UspA2 Moraxella catarrhalis and the C-terminal part of vitronectin and thus sheds light upon the mechanism of Moraxella catarrhalis-dependent serum resistance., Initial formation of IGROV1 ovarian cancer multicellular aggregates involves vitronectin., Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices, Neisseria meningitidis Opc expressed in acapsulate as well as capsulate bacteria can increase human brain endothelial cell line adhesion and entry by first binding to serum vitronectin, A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., The results provide the first evidence for vitronectin gene expression in urothelial cells., Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis., High serum vitronectin is associated with breast cancer., PAI-2 is capable of inhibiting uPA in the presence of PAI-1, particularly on adherent cells in the presence of vitronectin, A series of truncated vitronectin molecules revealed that the C-terminal domain comprising vitronectin(353-363) harboured the major binding region for Haemophilus influenzae protein E., higgh plasms levels is associated with the risk of metabolic syndrome and type 2 diabetes mellitus, In this study, the authors demonstrate meningococcal interactions with vitronectin via a novel adhesin, Msf (meningococcal surface fibril, previously NhhA or Hsf)., There was no difference in serum vitronectin levels between Behcet's disease patients and control subjects, and there was no statistically significant difference between vitronectin levels in Behcet patients with and without ocular involvement., A strong linkage disequilibrium was found in vitronectin promoter in Chinese with vascular disease., increased expression levels of VN protein and mRNA in placental maternal-fetal interface of EOSP may be involved in adhesion and repair of placental infarct lesions., Importance of vitronectin and its interaction with the urokinase receptor in tumor growth., An isogenic nontypeable Haemophilus influenzae 3655Deltahpf mutant devoid of protein F displayed a reduced binding of vitronectin, and was consequently more sensitive to killing by human serum compared with the wild type., In conclusion, the head domains of UspA2/2H have extensive sequence polymorphism without losing vitronectin-binding capacity promoting a general evasion of the host immune system., The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin., Interaction of vitronectin with integrin alphavbeta3 results in the continued activation of the kinase mTOR., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Authors demonstrate that an evolutionarily conserved rickettsial antigen, Adr1/RC1281, interacts with human vitronectin and is sufficient to mediate resistance to serum killing when expressed at the outer-membrane., Vn competes with hTSP-1 for binding to Atl repeats and vice versa. In conclusion, this study identifies the Atl repeats as bacterial adhesive structures interacting with the human glycoproteins hTSP-1 and Vn., Report role of vitronectin in the regulation of angiogenesis induced by VEGF., Gpm1 in Candida albicans attaches to human endothelial cells and to keratinocytes via the adhesive protein vitronectin, Melanoma cell adhesion to vitronectin is dependent on beta-1,6-branched N-glycans., The mean level of PAI-1 was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin was 83.10% +/- 23.77% (12%-126%) in the tumor group., The VN level may be relevant as a clinical biomarker for adverse cardiovascular outcomes not only in patients with ischemic heart disease undergoing coronary interventions., serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins., VTN plays a significant role in the malignant growth of tumor., Hic interacts with vitronectin and simultaneously with Factor H, and both human proteins may contribute to colonisation and invasive disease caused by serotype 3 pneumococci., A total of 17 site-specific N-glycopeptides were completely identified in all of the three N-glycosylation sites of vitronectin in human plasma, including 12 N-glycopeptides first reported., Vitronectin expression in the airways of subjects with asthma and chronic obstructive pulmonary disease, P. aeruginosa isolates obtained from CF patients significantly bound vitronectin. Porin D was defined as a novel P. aeruginosa vitronectin-receptor, Vitronectin is identified as a common constituent of amyloid deposits in 175 formalin-fixed and paraffin-embedded tissue samples from a large variety of different amyloid diseases., Lpd of P. aeruginosa is a surface exposed moonlighting protein that binds two human terminal pathway inhibitors, vitronectin and clusterin, Ail-expressing Yersinia pestis strains bind vitronectin - a host protein with functions in cell attachment, fibrinolysis and inhibition of the complement system., Bacterial protein-E and host vitronectin play a role in the attachment to bronchial epithelial cells and is also involved in the subsequent intracellular invasion of nontypeable Haemophilus influenzae., High expression of VN in tumor cells independently indicated poor clinical prognosis in patients with osteosarcoma.,
SP_COMMENT domain:The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin., function:Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity., function:Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway., PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both., PTM:N- and O-glycosylated., PTM:Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading., PTM:Sulfated on 2 tyrosine residues., similarity:Contains 1 SMB (somatomedin-B) domain., similarity:Contains 4 hemopexin-like domains., subunit:Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin., tissue specificity:Plasma.,