Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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fibronectin 1(FN1) fibronectin 1(FN1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q34,
ENSEMBL_GENE_ID ENSG00000115414,
GENERIF_SUMMARY Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium, We show a novel alternative pathway of apoptosis that is regulated by the alternatively spliced V region and high-affinity heparin-binding domain of fibronectin, Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride, Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading., Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus; multivariate analysis showed that plasma fibronectin levels were not an independent predictor of LV thrombus formation., Low density lipoprotein receptor-related protein (LRP) functions as a catabolic receptor for Fn, Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11)., differential role of u-PA and t-PA as inducers of fibronectin mRNA, investigation of the role of direct contact with stroma and the ECM protein fibronectin in the preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors, Adhesion of hairy cells to fibronectin inhibits interferon-alpha-induced apoptosis., fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility, Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., proximal tubular cell fibronectin production induced by oleate-complexed recombinant human serum albumin was mediated via protein kinase C activation, These data indicate that fibronectin polymerization is a critical regulator of extracellular matrix organization and stability., familial combined hyperlipidemia plasma stimulated secretion of several distinct hepatic proteins, among which fibronectin was identified, FN may be partly involved in the increase in SPARC (secreted protein, acidic and rich in cysteine) glycoprotein expression by TGF-beta 1 in human periodontal ligament (HPL) cells., REVIEW, Streptococcus pyogenes isolates were able to recruit collagen type IV via surface-bound fibronectin; fibronectin-mediated collagen recruitment represents a novel aggregation, colonization and immune evasion mechanism of S. pyogenes, FN may have a role in the pathogenesis of papillary thyroid carcinoma, all six modules of the gelatin-binding domain contribute to the interaction with gelatin either directly by contacting the ligand or indirectly through module-module interactions, differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the Sturge-Weber syndrome (sws) normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS., Fibronectin secretion by renal fibroblasts was increased upon exposure to high glucose, but with delayed kinetics compared to TGF-beta1-induced fibronectin., Pathogenic bacteria, Staphylococcus aureus and Streptococcus pyogenes, attach to human fibronectin through a tandem beta-zipper, AngRem104 is a novel human gene potentially involved in regulation of fibronectin induced by AngII in human mesangial cells., An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases., an additional marker of malignant potential of thyroid nodular lesions (oncofetal fibronectin), levels of fibronectin in the extracellular matrix are regulated by uPAR and integrin receptors, FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis., Fibronectin plus TNF-alpha stabilizes granulocyte macrophage-colony-stimulating factor (GM-CSF) mRNA, increases GM-CSF secretion, and prolongs in vitro eosinophil survival., Abundant expression of fibronectin is a major feature of leukemic dendritic cells differentiated from patients with acute myeloid leukemia, the aggrecanase activity of ADAMTS4 is inhibited by fibronectin through interaction with their C-terminal domains, crystal structure of the 2F1(3)F1 module pair, human fibronectin binding to streptococcus requires specific recognition of sequential F1 modules, Adding 110-120 kDa fibronectin fragments to normal blood replicated changes in monocyte CD49e, CD62L, CD11b, & CD86 seen in vivo in HIV-1 patients. FNf caused monocytes to release proteinase-3. Monocyte behavior in HIV-1 patients may be affected by FNf., Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., fibronectin concentration significantly elevated in ovarian cancer patients with recurrent disease compared with ovarian cancer patients without recurrence, demonstrate that integrins alpha(5)beta(1) and alpha(v)beta(3) support fibronectin-dependent platelet adhesion and the generation of filopodia but that, in contrast to the integrin alpha(IIb)beta(3), are unable to promote formation of lamellipodia, Site-directed mutagenesis of amino acids coordinating Ca2+ drastically decreased the binding of C-reactive protein to fibronectin (Fn), indicating that the Ca2+ -binding site indeed formed the Fn-binding site., Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, integrin-dependent function of the ninth and tenth FIII domains of human fibronectin depends on interdomain tilt angle, adhesion of uveal melanoma cells to the extracellular matrix proteins fibronectin, type IV collagen and laminin might confer resistance to the chemotherapeutic agent cisplatin, The heparin II domain of fibronectin mediated the incorporation of paxillin into focal adhesions., Fibronectin enhances IL-1 beta-dependent airway smooth muscle cell secretory responses through a beta 1 integrin-dependent mechanism., SGK1 activation has a role in oncofetal fibronectin expression, Fibronectin and ezrin were upregulated in primary laryngeal carcinoma., Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis., FN modulates thyroid cancer cell adhesiveness and, at least in part, mediates vitamin D actions on neoplastic cell growth., The relative amounts of the 60, 90 and 100 kDa FN fragments were 2-3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group, suggesting that seminal plasma FN fragments may contribute to fertilization., FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, Chemical shift differences between the fibronectin glycoforms have revealed an intimate interaction between one N-linked sugar and the polypeptide that is critical for gelatin binding., Over-expression of oncofetal fibronectin is associated with thyroid carcinoma, binding with C terminus of apolipoprotein [a], These results provide evidence for an additional level of control of fibronectin deposition through cell interactions with the local microenvironment., the role of the extra domain A (EDA) and type III connecting segment (IIICS) of fibronectin in fiber assembly, topographical distribution and proteolytic cleavage, Results show fibronectin plays a role in the regulation of hematopoiesis by binding to FLRG and follistatin., platelet fibronectin may have a role in progression of coronary artery disease, The expression of FN protein was higher in cortex cataract than in nuclear cataract., Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, Results indicate that the adhesion mechanism by embryonal fibronectin may be involved in human blastocyst implantation., constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP, review goes over roles of fibronectin in platelet functions with a focus on fibronectin assembly within developing platelet thrombi., Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., IL-1, FN, and FN-derivatives have interrelated roles in determining biomaterial-modulated macrophage function [review], The role of the matricryptic site of the fibronectin terminal repeat III1 in cell proliferation and growth is reported., Review highlights the role of fibronectin as a key orchestrator for the assembly of multiple extracellular matrix proteins., Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP., the FN1 alpha-helix is involved in an Ig5-FN1 interaction that is critical for the correct positioning of Ig5 N-glycans for polysialylation, analysis of L-isoaspartate formation and gain of function in fibronectin, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., Downregulated expression of migration-inducing FN-isoforms in contrast to unchanged FN receptor expression may contribute to the observed alterations of Crohn's disease colonic lamina propria fibroblasts migration., Our results indicate that Src maintains fibronectin matrix at the cell surface through its effect on integrin activity and paxillin phosphorylation., fibronectin does not have an obvious role in development or progression of coronary artery disease, epithelial fibronectin suppression is not only involved with malignancy, but can also occur with benign processes that involve leukocyte migration, local presence of endogenous Tlr4 ligand Fibronectin EDA is not associated with in an unstable plaque phenotype in humans, Interaction of fibronectin carboxy-terminal regions with the fibrin alpha C chain occurs through two types of binding sites, one with high affinity and another one with much lower affinity, both of which play a role during hemostasis and wound healing., Smad 7 transfection reduces the expression of COL1A2 mRNA and the synthesis of type I collagen, but has no effect on fibronectin mRNA expression., ED-B fibronectin expression is closely associated with inflammation in atherosclerosis., The IIICS region of FN is a novel zinc-binding module., Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production, MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the risk of lymphoma development in MCsn., TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., Fibrinogen has a role in controlling human platelet fibronectin internalization and cell-surface retention, study concludes that increased platelet fibronectin may partially contribute to platelet aggregation in patients with coronary artery disease, Expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC., These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., high molecular weight hyaluronan suppresses HBFN-f-activated NF-kappaB in rheumatoid arthritis chondrocytes, Results show that neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2)is co-expressed with migration stimulating factor (MSF or FN1) by keratinocytes and acts as a functional inhibitor of MSF., expression of the alternatively spliced extra-domain A (EDA) of fibronectin in the neovasculature of metastases and primary tumors of human cancer patients was shown, TSG-6 is a high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells, These data provide the first evidence that IL-18 and FN stimulate each other's expression., These results suggest that fibrinogen and fibronectin facilitate the adherence of Paracoccidioides brasiliensis conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system., dominant mutations in FN1 accounted for 40% of cases of Glomerulopathy with fibronectin (FN) deposits in our study group, These results are consistent with the hypothesis that ScpB binds to a motif created by the juxtaposition of multiple Fn molecules., The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin., Filtering bleb scarring is associated with an abundant expression of TGF-beta receptors in activated fibroblasts and the deposition of the fibrogenic ED-A fibronectin splice-variant., MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, KLK7 is able to cleave fibronectin in a time-dependent manner, but not laminin., Increased production of a fibronectin isoform containing the oncofetal domain and its release in the circulation in patients with primary biliary cirrhosis is at least partially responsible for the decrease in bone formation., Results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development., A link between fibronectin expression and epithelial cell growth during development and oncogenesis in the mammary gland., Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., Inflammation-induced modulation of FN-isoform production is involved in the alterations of migratory potential of CLPF isolated from CD mucosa., elevated plasma fibronectin levels are associated with venous thromboembolism (VTE) especially in males, and extend the potential association between biomarkers and risk factors for arterial atherothrombosis and VTE, four crystal structures that together comprise the structures of two complete high-affinity binding repeats for Fn from FnBPA and FnBPB, each in complex with four of the N-terminal modules of Fn, Plasma fibronectin level is increased in patients with severe coronary artery disease, namely, those who have at least one critically stenosed coronary vessel, compared to patients with normal coronary arteries., analysis of fibronectin expression in benign hyperplasia and cancer of the prostate, These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Genotyping for HaeIIIb fibronectin gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in mixed cryoglobulinemic syndrome., a new mechanism of fibroblast activation, which is initiated by interaction of fibronectin with its integrin receptors., MAGE A3 is a functional integrator of diverse signals, including FGFR2 and FN, to modulate cancer progression., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., The simultaneous positivity for thyroid specific factor TTF-1 and onfFN suggest they might represent putative thyroid cancer stem-like cells., analysis of the unfolding of the tenth type-III repeat of human fibronectin, Dynamic mechanical forces could regulate the expression of collagen type I and fibronectin mRNA in periodontal ligament fibroblasts., Mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and FNI(9)., enhanced capacity of fibronectin-adherent HL60 cells to differentiate into macrophages in response to PMA., The 320-kDa and 280-kDa FN forms as well as FN fragments appeared in the pleural effusion and plasma of patients suffering from lung inflammation or cancer in significantly higher relative amounts in both lung cancer groups than in the inflammation., relative amount of EDA-FN in synovial fluid, but not in plasma samples, was significantly lower in the early RA group than in established and late RA. In contrast, its level did not correlate with the CRP concentration, The risk of pneumoconiosis increases in workers with the FN (MspICC or HaeIIIb AA) genotype after exposure to dust. Workers both carrying FN (HaeIIIb AA) and (MspICC) genotypes are more susceptible to pneumoconiosis., role for fibronectin in collagen proteolysis and tissue remodeling, Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30., These results established a novel in vitro dynamic BBB model. We also demonstrated the dependence of leukocyte-endothelial interactions in this model on alpha4 integrins and FN-CS1., Human umbilical vein endothelial cells showed dose-dependent upregulation of fibronectin mRNA exposed to various D-glucose levels., Borrelia burgdorferi virulence factor BBK32 induces the formation of Fn aggregates that are indistinguishable from those formed by anastellin., isoforms of a group B streptococcus-secreted component named Fib displayed differential binding capacities for fibronectin, fibrinogen, and C4BP, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., fibronectin might be a critical molecule produced by T(H)1 cells involved in pathogen eradication., the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., LigB was shown to bind to the N-terminal domain of fibronectin., HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease, FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases., Serum fibronectin concentration in patients with hemorrhagic fever with renal syndrome (HFRS) was increased with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity., higher expression in the fetal skin than in adult skin, AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., Exposure to high glucose and overexpression AR increase the expression of fibronectin., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., the third FN type III repeat (FnIII3) and several fragments containing the repeat promote cell spreading and migration of human dermal fibroblasts (HDFs), whereas the fourth repeat (FnIII4) did not., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., vaginal fetal fibronectin not changed by vaginal ultrasound, Upregulation of fibronectin-1 protects Dicer knockdown HEK293T cells against apoptosis., findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., Increase in urinary fibronectin is associated with bladder tumor., The identification of a fibronectin-binding domain in ameloblastin might permit interesting applications for dental implantology., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., iso-DGR sequences spontaneously converted from NGR are cryptic and do not mediate the interaction of the 70K region of FN with the cell surface during FN assembly, Mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human cancer cells., Data demonstrated that the inclusion of the alternatively spliced angiogenesis-associated ED-B leads to the unmasking of the FNIII 8 B-C loop that is cryptic in FN molecules lacking ED-B., Exposure to ethanol drastically enhances the adhesion of cultured breast cancer cells to fibronectin and increases the expression of focal adhesions., Fibronectin promotes paxillin (tyr118) phosphorylation and invasiveness of AGS cells., An increased expression of fibronectin and tenascin-C mRNA in association to histological damage and in valvular heart disease compared to coronary artery disease could be shown., Fibronectin may modulate the directional migration of corneal epithelial cells, The expression of Col I, Col IV and Fn was closely related to tumor invasion, the regional lymph node metastasis and other pathological features in laryngeal squamous cell carcinoma., our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells., Steric hindrance determines the motogenic activity of MSF and Fn, and that both molecules contain cryptic bioactive fragments., in the presence of laminin and fibronectin, DC maintain a 'more immature' phenotype and express higher levels of key endocytic receptors, and become better endocytic cells, but possess superior ability to induce antigen-specific T cell differentiation., Oncofetal fibronectin transcripts are highly abundant in the peripheral blood of patients with papillary thyroid carcinoma., Elevated urinary fibronectin was identified as an independent factor predicting kidney function deterioration., Data show that metastatic outgrowth is associated with activation of the transforming growth factor-beta signaling pathway and concerted up-regulation of POSTN, FN1, COL-I, and VCAN genes., plays role in bronchial smooth muscle cells migration in the process of airway remodeling, Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac activation by mGBP-2., Data show that occupancy of EPCR by protein C switches signaling specificity so that activation of PAR-1 by thrombin inhibits TNF-alpha-mediated synthesis of IL-6 and IL-8 and down-regulates TGF-beta-mediated expression of collagen type 4 and fibronectin., MSF is a novel marker associated with the M2 stage of macrophage polarization expressed by tumor-conditioned macrophages; MSF may contribute to macrophage-mediated promotion of cancer cell invasion and metastasis., high molecular weight of HA suppressed the FN-f-activated p38 via ICAM-1 and the CD44 in RA chondrocytes, Migration Stimulating Factor, a truncated form of fibronectin that promotes the migration of many cell types, inhibits AKT activity in human fibroblasts, data indicate that higher levels of EDB isoform and FN-f are associated with intervertebral disc degeneration; this shift in alternative splicing may reflect an attempt of tissue repair and remodeling, FN induces MMP-9 in HEp-2 cells mainly by involving integrin receptor alpha5beta1 and involves activation of multiple signaling pathways which independently or in "cross-talk" to each other finally leads to the transactivation of the MMP-9 gene., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, Fetal fibronectin as a predictor of spontaneous preterm birth., Data show that FN III12-14 is a highly promiscuous ligand for GFs and also holds great potential in clinical healing applications., FN upregulates osteoclast activity despite inhibiting osteoclast formation and that these effects involve NO and IL-1beta signaling., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., Tenascin-C contains cryptic sites which can control tissue levels of fibrillar fibronectin either by preventing de novo fibril assembly or reducing levels of deposited fibronectin., In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal., The findings that fibroblast survival is dependent on FN-growth factor binding domains underscore the critical importance of pericellular matrix for cell survival, CTGF cooperates with FN in enhancing the attachment and migration of corneal epithelial cells., Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion., IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin, High FN1 mRNA expression is associated with renal cell cancer., rhFNHN29 and rhFNHC36 inhibit adhesion and invasion of liver cancer cells, syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides, study suggests that FN and tissue transglutaminase (TG2) facilitate the metastatic activity of A431 tumor cells, and this may be partly attributed to TG2 enhancement of the association of FN and beta integrin, These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins., Megakaryocyte adhesion to type I collagen promotes inhibits pro-platelet formation through the release of cFN to the plasma membrane. This regulatory mechanism is dependent on the engagement of FN receptors and on transglutaminase FXIII-A activity., autocrine soluble fibronectin of osteosarcoma MG-63 cells may be involved in cell shape maintaining, Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve., FN upregulation of cGMP-dependent protein kinase (PKG-I) protein content is due to increased mRNA expression via augmented transcriptional activity of the PKG-I promoter region., Cav1.2 calcium channel association with alpha5beta1-integrin depends on adhesion to fibronectin; interactions between alpha5beta1-integrin and fibronectin modulate L-type calcium channel entry., Fetal fibronectin may be used as a primary screening tool for prediction of preterm birth in asymptomatic high-risk women., Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP., Danshensu can protect from oxidative stress through inhibiting the expression of FN and Col-I induced by high glucose., Kindlin-2 regulates podocyte adhesion and fibronectin deposition through interactions with phosphoinositides and integrin b1 and b3., Data show that ITP-79 modulated binding of TG2 to fibronectin., LigB could facilitate leptospirosis transmission by binding fibronectin and fibrinogen, Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression., Increase expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas., This work provides a broad overview of matrix remodeling at the cell-material interface, establishing correlations between surface chemistry, fibronectin adsorption, cell adhesion and signaling, matrix reorganization and degradation., We conclude that TGF-beta1 may both switch on and switch off migration stimulating factor (MSF) expression in a manner critically determined by the nature of the matrix substratum, Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage, Data show that the urinary messenger RNA (mRNA) levels of alpha-smooth muscle actin (alpha-SMA), fibronectin, and matrix metalloproteinase-9 (MMP-9) were significantly higher in the diabetic nephropathy (DN) group, and mRNA levels increased with DN progression., Structural and functional analysis of the tandem beta-zipper interaction of a Streptococcal protein with human fibronectin, Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn., The adhesive properties and thickness of the UspA1 layer at the cell surface varies on addition of either fibronectin or CEACAM1., miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line., the extent of molecular unfolding that contributes to Fn fiber extension, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted AGS cell migration was due to the up-regulation of fibronectin., Fibronectin matrix assembly suppresses dispersal of glioblastoma cells, Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier, Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein, first step in such infections is a bond that forms between fibronectin-binding protein (FnBP) on Staphylococcus aureus and host proteins, such as fibronectin (Fn), that coat the surface of implants in vivo., Data indicate that anti-citrullinated fibronectin peptide antibodies are associated with HLA-DRB1 shared epitope alleles., Allosteric loss of constraining interactions among (1-5)FNI, (10)FNIII, and (12-14)FNIII likely enables assembly of FN into extracellular fibrils., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, these findings provide evidence that extra domain A of fibronectin could play a role in tumor-induced lymphangiogenesis via upregulating autocrine secretion of VEGF-C in colorectal cancer, which is associated with the PI3K/Akt-dependent pathway., Study demonstrated that fibronectin inhibition and neutralization by specific antibody prevented significantly the adhesion of A. baumannii to human lung epithelial cells (A549 cells)., study concludes that increased serotonylation of fibronectin occurs in pulmonary hypertension, Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin, High expression of fibronectin is associated with esophageal squamous cell carcinoma., Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC)., Genistein attenuates advanced glycation end product-induced expression of fibronectin and connective tissue growth factor, Collagens regulate the EDA(+)-FN-ECM organisation at transcriptional and post-transcriptional level and activate the alpha5beta1-FAK complexes., Gene expression profiles showed that FN1 was up-regulated in epidermolysis bullosa subtypes., Reduced expression of two specific integrin subunits, alpha 5 andalpha V, resulted in the inability of MG63 cells to deposit fibronectin into their extracellular matrix, influenza A Virus entry with a alpha2,6-linked sialic acid binding preference requires host fibronectin, MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., FN1 assembly and the lung colonization of suspended CL1-5 cells were inhibited when endogenous A1AT protein was knocked down using siRNA., MSF functions in the metabolic remodeling of the tumor microenvironment., Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin., our results suggest that plasma PTPalpha and fibronectin may be associated with opisthorchiasis., Data indicate that fibronectin mRNA and protein levels were significantly down-regulated following the upregulation of serine protease HTRA1., Serum oncofetal fibronectin mRNA in differentiated thyroid carcinoma cannot identify those with metastatic disease., FN1 and ITGA4 are potential oral squamous cell carcinoma biomarkers for tongue/mouth floor and edentulous ridge., Data indicate that rheumatoid synovial fibroblasts have impaired adhesion and spreading on citrullinated fibronectin, but focal matrix degradation is unaffected by citrullinated fibronectin., We confirm WNT4, CDKN2BAS and FN1 as the first identified common loci for endometriosis., An algorithm based on fetal FN for management of preterm labor (PTL) does not reduce evaluation times for triage, hospital admissions or preterm deliveries., Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression in the U87 glioblastoma cell line, Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., Lactobacillus iners AB-1 displays a mechanism of vaginal persistence to human fibronectin, with implications for human reproductive health., Authors report that group A Streptococcus biofilm formation is mediated by the Scl1 interaction with extra domain A-containing cellular form of fibronectin., Data indicate that citrullinated fibronectin (cFn) plays a potential pathophysiologic role in rheumatoid arthritis (RA) by inhibiting apoptosis and increasing proinflammatory cytokine secretion of fibroblast-like synoviocytes (FLSs)., Data indicate that four different Anticalins all show low nanomolar affinities for fibronectin (Fn) extra-domain B (ED-B)., MOMCs were obtained on the fibronectin., Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of fibronectin., genome-wide association study of population in Northern Belgium, Data indicate that endopeptidase O (PepO) is a ubiquitously expressed plasminogen- and fibronectin-binding protein, which plays role in pneumococcal invasion of host cells and aids in immune evasion., The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8., Treated neutrophils aggregate on fibronectin (Fn)-coated wells and exhibit an exaggerated cell aggregation phenotype on wells coated with Fn plus beta-glucan., The metabolism of glucose through hexosamine biosynthetic pathway promotes O-glycosylation of the oncofetal form of FN during epithelial-mesenchymal transition modulating tumorogenesis., fibronectin is a key factor in human serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture., Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis., High glucose and AGEs can up-regulate the expressions of ROS and fibronectin in human mesangial cells by activating transcriptional co-activator p300., Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN)., Collagen association stabilizes a distinct monomeric fibronectin gelatin-binding domain conformation in solution., Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer., The predicted 23-residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with the tenth FN type III domain., We identified 31 interactors from plasma, of which only seven were previously known to interact with fibronectin, Data indicate tht mRNA expression of elastin, procollagen I type I, fibronectin, Col1alpha1, and TIMP-1 had a significant increase after bicyclic[1,2,3]triazoles plus UVA treatment, while the MMP-1 decreased, compared with the UVA irradiated group., We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, MSF expression was upregulated in NSCLC tumors and promoted migration and invasion in A549 cells., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, Four members from clusters of the miR-200 family (miR-200a/-200b/-429 and miR-200c/-141), epithelial-mesenchymal transition could potentially play a role in the pathogenesis of pterygium., Low extra domain A fibronectin expression is associated with bacterial meningitis., The SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Data suggest that determination of the fibronectin content can serve as a prognostic biomarker for breast and prostate cancers and possibly other cancers., Together these results show that FN produced by the tumor cells has a role in glioblastoma multiforme pathophysiology and they provide insights into the implications that targeting FN interactions may have for combating this dreaded disease., profile of fibronectin fragmentation and alterations of fibronectin domain immunoreactivities in seminal plasma may influence their engagement in the fertilisation process, First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for gestational diabetes., We demonstrate that the high FN content of the endometrium matrix, and not specifically the EDA domain, supports trophoblast invasion by showing that forced incorporation of plasma FN (EDA-) promotes efficient trophoblast invasion, Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy., Perturbing the mesenchymal regulators, platelet-derived growth factor (PDGF) receptors or fibronectin, reverts mesenchymal stromal/stem cells (MSCs) toward mesodermal progenitors with endothelial potential., cFN isoform expression in the TM ECM may be a novel pathologic mechanism involved in the TM changes associated with glaucoma., expression of miR-206 and its target gene, fn 1, may contribute to the progression of bronchopulmonary dysplasia, Fibrillins require the complete gelatin-binding region of fibronectin for interactions., Fibronectin is upregulated in a subset of nasopharyngeal carcinomas , and its increased immunoexpression significantly correlated with advanced features, justifying the potentiality of fibronectin as a theragnostic biomaker of nasopharyngeal carcinomas ., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., the dual antibody approach utilizes commercially available antibodies and simple immunohistochemistry, thus making it accessible to a wide range of scientists interested in fibronectin mechanobiology, Oncofetal fibronectin levels are potentially useful as a biomarker for urothelial inflammation and repair., Eppin and Fn bind to each other in human semen and on human ejaculated spermatozoa., Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens., Identify FN1(high)MITF(low) cell type in melanoma associated with ischemic necrosis, and propose these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment., This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in Duchenne muscular dystrophy patients., Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis., Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5., Data indicate that ibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA) is sterically regulated by fibronectin binding., Most of these motifs are located on the F1 and F3 faces of the Hap passenger domain structure, suggesting that the F1 and F3 faces may be responsible for the Hap passenger domain-fibronectin interaction., Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition, We proved that the CD157-fibronectin interaction occurs with living cells, where it elicits CD157-mediated cell responses., MMF could inhibit MCP-1 expression and the secretion of FN, indicating that it may delay the progression of glomerulosclerosis and interstitial fibrosis in diabetic nephropathy to ultimately achieve protective effects on the kidney., Data indicate the expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in cardiac tissue from heart transplant recipients., The mean level of cellular fibronectin expression in cases with liver fibrosis was significantly higher than the corresponding level in cases with liver cirrhosis., rFN/CDHs may induce hMSCs differentiation into osteoblasts and PLGA/collagen nanofibers loaded with rFN/CDHs have potential in bone tissue engineering., The AT heterozygote in FN-1 (rs940739A/T) was found to be significantly associated with knee osteoarthritis in 2 case-control studies. FN-1 rs6725958C/A was significant only if both studies were combined., Results found that the majority of colorectal cancer cases with depressed tumors had a higher frequency of elevated FN1 expression., High fibronectin expression is associated with thyroid papillary carcinoma follicular variant., the possible regulatory effect of fibronectin peptides in liver fibrosis was further supported by the ability of these peptides to induce metalloprotease-9 (MMP-9) expression in human monocytes., homophilic fibronectin binding peptides might have novel applications in the field of tissue regeneration as tools to regulate neovascularization via VEGF signaling, serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells., Study tested the role of the histone acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon; these data suggest that histone acetylation could be one of the mechanisms how promoter and promoter binding proteins influence alternative splicing., Data indicate that the IL-33/ST2 protein pathway may promote airway remodeling in asthma through activating HLF-1 fibroblast to over-express fibronectin 1 (FN1) and type 1 collagen (Col1)., fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis, These results have indicated that the cysteine proteinase of Trypanosoma cruzi metacyclic forms, through its fibronectin-degrading activity, is implicated in host cell invasion., PEDF inhibited breast cancer cell migration and invasion by down-regulating fibronectin, Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour., Data indicate that the interaction between the alpha4beta1 integrin and the EDA domain of fibronectin helps to drive tissue fibrosis by promoting a contractile phenotype and an increase in fibronectin synthesis and deposition., The expression of terminal sugars on milk FN is different from that of plasma FN of the lactating mother and is associated with milk maturation., Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells., Fibronectin gene expression has a potential role in the pathogenesis of keloid., Genetic induction of fibronectin by HER2 triggers cell adhesion and invasion capacities., Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin and collagens by a laminin-rich matrix, we describe a new type of hybrid molecules including 10th type III human fibronectin domain (10Fn3) - one of the alternative scaffold proteins which can be used for the construction of antibody mimics with various binding specificity, Serum fibronectin was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. Fibronectin increased with nephropathy severity., Fn Msp iv polymorphism appeared to be associated with diabetic nephropathy susceptibility., Serum- and CSF-FN levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis., These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway., Data show that the amount of the the extra domain-B (EDB) splice variant of fibronectin (FN) produced by endothelial cells increases with matrix stiffness., The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, An observed increase in PLD activity was mediated through boosting the binding of PLD with dynamin which in turn facilitated fibronectin-induced cell spreading., Asthmatic human bronchial epithelial cells are intrinsically primed to produce more fibronectin, which when deposited into the extracellular matrix, is capable of driving remodeling and inflammation., The pathogenic H5N1 and H7N9 influenza virus variants cause more severe deregulation of NRF2 and fibronectin in host epithelial cells than the less pathogenic H1N1 variant., Study determined the structure of third type III domain, 3FN3 using nuclear magnetic resonance spectroscopy, and investigated its stability, folding, and unfolding., polymorphisms in rs6725958, rs10202709, and rs35343655 of the Fn gene had no obvious effect on the susceptibility to the development of calcium oxalate stones in the Uighur population, residing in the Xinjiang region of China., Fibronectin binding to heparan sulfate mediates exosome-cell interactions in Myeloma., the correlation between placental DNAm of INHBA/FN1 and maternal serum INHA/FN1 levels indicate that DNAm may be a useful tool to identify novel biomarkers for adverse pregnancy outcomes in some cases., that strong FN1 promoter activity drives inappropriate expression of the biologically active portion of EGF, These results suggest novel functions of endogenous FN involved in immune evasion and maintenance of hepatitis b virus replication.,
OFFICIAL_GENE_SYMBOL FN1,
OMIM_DISEASE Glomerulopathy with fibronectin deposits 2, Plasma fibronectin deficiency,
SP_COMMENT alternative products:Additional isoforms seem to exist, developmental stage:Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age., disease:Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life., function:Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth., online information:Fibronectin entry, PTM:Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)., PTM:It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated., PTM:Sulfated., similarity:Contains 12 fibronectin type-I domains., similarity:Contains 16 fibronectin type-III domains., similarity:Contains 2 fibronectin type-II domains., subunit:Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7., tissue specificity:Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.,
hepatocyte growth factor(HGF) hepatocyte growth factor(HGF) Related Genes Homo sapiens
CHROMOSOME 7,
CYTOBAND 7q21.1,
ENSEMBL_GENE_ID ENSG00000019991,
GENERIF_SUMMARY hepatocyte growth factor Downregulates E-cadherin and Desmoglein 1 during melanoma development, Hepatocyte growth factor, Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway., Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos., Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer, Polymorphonuclear neutrophils are a source of hepatocyte growth factor in patients with severe alcoholic hepatitis., Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription., Unlike other growth factors, HGF did not show any activity on the fibrinolytic system in both normal and dystrophic myoblasts., regulation of production, subcellular localization and molecular form in neutrophils, play important roles in lung development, lung inflammation, and repair., role in inhibiting anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B, a diagnostic marker of thrombus formation in patients with cerebral infarction., A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping., HGF/SF decreased transendothelial resistance (TER) and increased paracellular permeability in human vascular endothelial cells, HGF in combination with vitamin D3 may have an autocrine and/or paracrine effect on the osteogenic maturation of bone marrow stromal cells, as well as on bone repair and remodeling., These results suggest that hepatocyte growth factor and interleukin-6 upregulate each other's receptors, and thus cooperatively enhance tissue invasion., Data show that thymosin beta4 was differentially expressed in HGF-treated HUVECs compared with control., HGF and HGFR have an alternative role activating the via STAT3 transdution and operating on placental tissues, overall in organogenesis alteration conditions, The serum level of HGF represents the degree of the carcinogenic state in the liver of patients with C-viral chronic hepatitis and cirrhosis., Overexpression of HGF/c-met appears to be a biological feedback response to the fibrotic process of systemic sclerosis., HGF induces a strong and transient tyrosine phosphorylation of c-Cbl, resulting in an increased association with Fyn, Lyn, PI-3K, and CrkL., aberrant signaling involvement in rhabdomyosarcomagenesis, plasma kallikrein and FXIa activate pro-HGF in vitro, NK4-transfected clone showed significant inhibition of pancreatic tumor progression in both the orthotopic implantation and liver metastasis models, Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration., HGF may stimulate the progression and growth of tumor cells in vivo by induction of Cox-2, Increased expression of HGF and KGF by buccal mucosal fibroblasts may partly be responsible for the faster wound healing with less scar formation in the oral cavity compared with normal skin., HGF, but not VEGF, serum levels in the coronary circulation correlated with left ventricular remodeling, suggesting HGF interaction in the wound-healing process associated with inflammation after AMI, in human tumor cells, HGF and M-CSF stimulate osteopontin production (which is subsequently used as a substrate for cell adhesion), The production of this factor in kidney increases after unilateral nephrectomy., immunoexpression of hepatocyte growth factor and c-Met in the eutopic endometrium of patients with pelvic endometrioisis is possibly useful to predict greater activity of the ectopic endometrium, These results argue for growth factor-dependent hepatocellular carcinoma development and provide novel and combined prognosis markers after HCC surgery., In the presence of keratinocytes, fibroblasts from buccal mucosa, periodontal ligament, & skin increased increased HGF and KGF production 2-3 times. This may influence the proliferation & migration of junctional epithelium and affect periodontal disease., The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma., Tetranectin binds to this protein and TTPA., Post-myocardial infarction human HGF gene therapy improved LV remodeling and dysfunction through hypertrophy of cardiomyocytes, infarct wall thickening, preservation of vessels, and antifibrosis in a mouse model, Autocrine and paracrine support of HGF-c-Met system attenuates degeneration of anterior horn cells in amyotrophic lateral sclerosis. Disruption of neuronal HGF-c-Met system at advanced stage accelerates cellular degeneration and cell death., HGF and VEGF modulate the expression of cell adhesion and migration molecules and induce proliferation in endothelial cells, which may contribute to chronic hepatitis C-associated liver angiogenesis., stimulates eNOS activity by a PI3K/Akt-dependent phosphorylation in a Ca(2+)-sensitive manner in vascular endothelial cells, HGF increased the invasive potential of prostate cancer cells probably through enhancement of cell motility and the production of MMPs and u-PA, Hepatocyte growth factor may be a mediator of heparin-induced osteoporosis., HGF found in articular cartilage is produced by osteoblasts, diffuses into the cartilage, and may be implicated in the osteoarthritic process., Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells, Amyloid beta-protein expression and secretion are regulated via activation of ERK1/2 by HGF in cells transfected with APP751., N-terminal domain of HGF inhibits angiogenesis not by disrupting the HGF/c-met interaction but rather by interfering with the endothelial glycosaminoglycans., HGF, SDF-1, and MMP-9 have roles in stress-induced human CD34+ stem cell recruitment to the liver, results show that HGF suppresses TGF-beta1-mediated renal interstitial myofibroblastic activation; and this action of HGF is likely related to a mitogen-activated protein kinase-dependent blockade of Smad nuclear translocation, After acceleration of regenerative response by HGF, subsequent elevation of TGF-beta1 synergistically controls graft size, regulating uncontrolled proliferation of hepatocytes., hepatocyte growth factor and c-Met/HGF receptor have roles in prostate neoplasm progression, HGF/SF-met signaling may up-regulate oncogenes, signal transduction genes, apoptosis-related genes, metastasis related genes, and down-regulate a number of genes., hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses compared to uncomplicated pregnancies, HGF is modulated by stanninocalcin 1 and has roles in wound healing, tissue regeneration, and angiogenesis, DFNB39, a recessive form of sensorineural hearing impairment, maps to chromosome 7q11.22-q21.12, Retroviral ribozyme transgenes targeting HGF/SF in fibroblasts or its receptor cMET in mammary cancer cells can reduce the growth of mammary cancer and associated angiogenesis by inhibiting paracrine stromal-tumor cell interactions., c-Met and HGF-SF have roles in the growth and progression of human and canine osteosarcoma, Mediates angiogenesis in cultured cancer cells by regulating the expression of hepatocyte growth factor and thrombospondin 1., regulation of expression is affected by stat3 activation, the role of HGF in basement membrane formation during wound healing by immortalized alveolar type II epithelial cells, Serum HGF levels did not change significantly after adult-to-adult living donor liver transplantation with right lobe graft., higher levels in vitreous body of people with proliferative retinopathy in vitrectomy, Densisty of HGF in hepatic allograft biopsy specimens compared with those from a control group of healthy patients., Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis., Relationship of intercellular adhesion molecule-3 and hepatocyte growth factor with amyloidosis A in chronic renal-failure patients.There was no significant difference regarding the level of positivity for hepatocyte growth factor., HGF/Met system is involved in the pathogenesis of endometriosis by promoting stromal cell proliferation and invasion of shed endometria and endometrial lesions via autocrine and paracrine pathways., Shc is a critical angiogenic switch for VEGF production downstream from the HGF and ErbB2 RTKs., Decreased HGF may be related to vascular endothelial cell damage in the development of pregnancy induced hypertension., Quantitative-histogram scores of HGF in cuboidal or columnar cells surrounding red lesions showed statistically significant correlation with accumulation of macrophage in cells; no similar correlation was demonstrated for black lesions., two convergent proinvasive agents secreted by myofibroblasts, namely hepatocyte growth factor and the TGF-beta-upregulated extracellular matrix glycoprotein tenascin-C, are each necessary though not sufficient for neoplasm invasion, HGF polymorphism may be a candidate susceptibility loci that affects the progression of carotid atherosclerosis in japanese population., a decrease of insulin-like growth factor 1 along with an increase of hepatocyte growth factor may reflect an underlying biological process that influences cognitive decline as well as carotid atherosclerosis in the elderly, Theca cell-derived HGF may be capable of stimulating the proliferation of granulosa cells and suppressing progesterone synthesis via an activating MAPK pathway., Increased levels of HGF in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma, C/A polymorphism in intron 13 of the HGF gene is associated with susceptibility to essential hypertension in lean or female subjects., The HGF/c-met signaling system may have an important role in hMSC recruitment sites of tissue regeneration., autocrine/paracrine role of HGF in glial cell responses during proliferative vitreoretinal disorders as well as in retinal neovascularization, by stimulating of VEGF release, elevated plasma levels in systemic inflammatory response syndrome and bacterial infections, hepatocyte growth factor (HGF) activation is catalyzed by multiple myeloma cells secreting the serine protease HGF-activator, early spreading responses to HGF may partly relate to increased paxillin availability for incorporation into, and turnover within, dynamic cytoskeletal/membrane complexes whose rapid and transient adhesion to the matrix drives migration., both Met and HGF are overexpressed in papillary thyroid carcinomas, catalase and hepatocyte growth factor have roles in ceramide-induced apoptosis, Increased serum HGF concentrations correlate with the presence of thrombi in patients with acute coronary syndrome, acute aortic dissection, and pulmonary thromboembolism., Results indicate that hepatocyte growth factor plays a role in regulating dendritic morphology in the developing cerebral cortex., A positive correlation between platelet count in liver cirrhosis and serum level of thrombopoietin and hepatocyte growth factor was observed., By regulating HIF-1 activity and specific gene expression downstream, NF-kappaB may influence the survival threshold, with an impact on the fate of carcinoma cells after prolonged hepatocyte growth factor treatment., HGF and IL-1ra adhesion-dependent release from human blood granulocytes and monocytes involves plasma IgG, complement C3 and beta2 integrin, may have an important role in cyclosporin-induced gingival overgrowth, Mitogenic effects of HGF on hepatocytes may be accompanied by undesired cholangiogenesis and angiogenesis, Hepatocyte growth factor/scatter factor-mediates activation of Met and consequent downstream signaling in the glycosaminoglycan metabolism., Transfected HGF is expressed in hepatic cells and has the activity of promoting cell division and protecting hepatic cells against poisoning., HGF plays an important role in hepatocyte proliferation but contrary to in vitro results, HGF does not play a major role for the progression of hepatocarcinoma cells in vivo., Semiquantitative analysis of HGF mRNA expression between decidua basalis and decidua parietalis showed no statistically significant difference., The autocrine mechanism between over-expressed c-Met and HGF/SF in malignant tumors is part of the process of pleural metastatic spread., Administration of rh-HGF before storage improved cardiac function after prolonged myocardial preservation by preventing apoptosis through c-Met/HGF receptor. May be promising strategy for prolonged heart graft preservation., HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves, The beneficial effect of HGF in chronic renal disease is attributable, at least in part, to a direct anti-inflammatory action, likely via NF-kappaB, on tubular epithelial cells., Exogenous hHGF reduced rat lung expression levels of endothelin-1 & transforming growth factor-beta, pulmonary artery medial wall thickening, and the total collagen deposition in the lung., Correlation between the vitreal levels of scatter factor and VCAM-1 was observed in diabetic patients., This study revealed that HGF is densely found in the carotid fork, and its CSF level is markedly elevated in moyamoya disease, suggesting that HGF may be a key protein for pathogenesis of moyamoya disease., HGF specifically induced the expression of Smad transcriptional co-repressor SnoN but not Ski and TG-interacting factor at both mRNA and protein levels in kidney cells, Suppressed intestinal mRNA expression of T-helper 1 cytokines. Total and CD4-positive T cells, neutrophils, and myloperoxidase activity in intestinal epithelium were diminished by HGF gene transfer, which also prevented weight loss and improved survival., The HGF has a role of signal in colon tumorigenesis that is associated to progression of adenoma into carcinoma., is produced by peritoneal macrophages and is possibly involved in the growth of endometriosis, HGF induces fibronectin expression and its extracellular assembly on the surface of melanoma cells through activation of mitogen-activated protein (MAP) kinase pathway, and induction and transcriptional activation of Early growth response-1 (Egr-1)., Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane, in chronic skin ulcers, decreased biological activity of endogenous HGF and overexpression of c-met may have roles in fibrosis and delayed recovery, Hepatocyte growth factor(HGF/SF)facilitates intercellular communication between the epithelial carcinoma and surrounding stromal tissue during metastatic invasion through interaction with its proto-oncogenic receptor, Met, found on carcinoma cells., HGF/MET signalling protects Plasmodium sporozoite-infected host cells from apoptosis., HGF electrogene therapy would prevent liver from radiation-induced liver damage by preventing apoptosis and down-regulation of TGF-beta1., all-trans-retinoic acid augments the induction of HGF production caused by increased intracellular cAMP, inhibition of RANTES expression is mediated by activation of PI3K-Akt-GSK3beta pathway, a novel activity of HGF-the stimulation of NO production-which occurs via eNOS phosphorylation that may in turn be mediated by cross-talk between the PI3K/Akt and MAPK pathways, HGF/SF released FGF-2 in the matrix but did not induce FGF-2 expression in external auditory canal cholesteatoma., Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice, TGF-beta1 inhibits hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cells, HGF is involved in the development and/or progression of gastric carcinoma through an autocrine mechanism, IL-6 and TNFalpha are involved in the production of HGF by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism, results reveal a signaling pathway for G1 arrest induced by HGF, hepatocyte growth factor has a role in acute myeloid leukemia, It is concluded that level and duration of MAPK activation by Met receptor are crucial for the induction of a full HGF-dependent mitogenic and invasive program in KS cells., Hepatocyte growth factor promotes lymphatic vessel formation and function., Circulating HGF may counteract thrombogenesis by negatively modulating platelet functions., HGF modulates endothelial K+ channels causing an activation of the eNOS; the increase of nitric oxide is necessary for the phosphorylation of the MAPK inducing the proliferation of HUCVEC., This article reviews the published evidence of the roles hepatocyte growth factor/scatter factor plays in prostate cancer progression., Significantly higher serum HGF level is associated with esophageal squamous cell carcinomas, expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema; hepatocyte growth factor mRNA correlates with severity of airflow obstruction in smokers, Recombinant human HGF accelerates the regeneration of severely damaged livers, a situation in which the proliferation of mature hepatocytes is impaired., XIAP expression in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling, The crystal structure of the beta-chain of HGF was studied., A potential physiological pathway for inactivation of HGF and generation of NK4-like antagonists., The presence of HGF receptors in the processus vaginalis is consistent with a role for HGF in triggering epithelial-mesenchymal transformation during inguinal hernia closure, Overexpression of the hepatocyte growth factor gene results in liver defects in Agille syndrome, p70S6K activation induces expression of MMP-9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells, The consistent expression of HGF and c-met during the perinatal period supports a physiological role for HGF in human lung development., HGF has pivotal role for functional recovery after cerebral infarction through neuritogenesis, improved microcirculation, and prevention of gliosis. Evidence for feasibility of gene therapy in chronic stage of cerebral infarction., Upon injury, skin keratinocytes might produce biologically active HGF in an autocrine fashion. This HGF might have different structural and/or biological properties from HGF produced by mesenchymal cells., Liver cancer patients had a significantly higher level of serum hepatocyte growth factor than normal controls, Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, where they play a role in tissue repair/regeneration., HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition., HGF orchestrates several biochemical pathways, which allow cell survival under cell stress conditions encountered during tumor progression, overccoming the death signal of sustained p38 MAPK activation., A specific upregulation of HGF synthesis by Oncostatin M supports the suggestion that oncostatin M may participate in lung repair through HGF production., As discussed in this review, receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration., Granulocytes transport HGF in peripheral blood to injured sites caused by blood coagulation, where HGF may promote tissue repair., This is the first study reporting the association of an HGF gene polymorphism with high myopia., progenitor cells are potent sources of VEGF, HGF, and IGF-I, Promotes survival of RPE(rertinal pigment epithelium) cells and retinal neurons, the inhibition of production of HGF by visible light, especially by blue light, may enhance the phototoxic effects of visible light on the RPE and retinal neurons., HGF/SF has a role in increasing tumor blood volume, Serum HGF levels were higher in non-alcoholic steatohepatitis patients than in the controls, These results suggest that the sustained phosphorylation of Gab1 through Crk in response to HGF contributes to the prominent activation of Rac1., HGF gene transfection inhibited T helper 2 immune responses and reduced lupus nephritis, autoimmune sialoadenitis, and cholangitis in chronic GVHD mice. HGF may be novel strategy for treatment of SLE, Sjogren's syndrome, and primary biliary cirrhosis., neurons treated with hepatocyte HGF increased expression of the N-methyl-D-aspartate receptor NR2B subunit, calcium/calmodulin-dependent protein kinase II, and GluR1 subunit of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor, These findings suggest that HGF has potent and direct anti-inflammatory effects on the basis of suppression of NF-kappaB activation and downstream endothelial inflammation., HGF-mediated PAI-1 production may provide a novel link between atherothrombosis and metabolic derangements. Targeting HGF signaling pathway may modulate the thrombotic risk in high-risk patients., Mimp expression reduces hepatocyte growth factor/scatter factor-induced proliferation and scattering by attenuating and altering the downstream signaling of met proto-oncogene., HGF stimulation led to increased agar colony formation of esophageal adenocarcinoma., Novel c-Akt-regulated genes contributing to Scatter factor-mediated antineoplastic drug resistance., Serum levels of HGF/SF are associated with the clinical course of metastatic breast cancer patients with liver metastases., HGF induces genes favoring growth and is mitogenic when HepG2 cells are plated under low density; however, the opposite occurs under high density, In angiographically silent cardiac allograft vasculopathy, circulating HGF may have a protective effect on vascular endothelium and thus attenuate the severity of intimal hyperplasia., HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells, glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk, Expression of nephrin mRNA as well as nephrin promoter activity was suppressed by a putative dedifferentiation factor of podocytes, hepatocyte growth factor., HGF may facilitate osteophyte development by promoting MCP-1-mediated entry of monocytes/macrophages into the osteoarthritis-affected joint and/or by stimulating macrophage-derived growth factors, HGF secreted by subepithelial fibroblasts contributes to human bronchial epithelial cell differentiation., HGF stimulation of c-Met-overexpressing H69 small cell lung cancer cells (40 ng/ml, 15 min) resulted in an increase of reactive oxygen species, although serine proteases and HGF have quite distinct functions in proteolysis and Met signal transduction, respectively, they share a similar activation mechanism, These results indicate that cytokines and PGE(2) may indirectly mediate epithelial cell proliferation via the regulation of HGF in bronchial stromal cells and that HGF plays a crucial role in proinflammatory cytokine-induced proliferation., Salivary HGF measured at baseline may predict future alveolar bone loss., HGF measured during the early posttransplant period might be a useful parameter for early detection of acute renal allograft rejection, HGF has a role in the IL-1-induced chemokine response of epithelial cells in inflamed mucosal tissues., HGF appears best suited for stimulating production of hyaluronic acid and elastin, which may be essential for normal superficial lamina propria restoration., HGF can directly or indirectly stimulate lymphangiogenesis and contribute to lymphatic metastasis in gastric cancer., Imbalance in c-Met expression between tumour and surrounding normal tissue is associated with aggressive ductal carcinoma in situ phenotype. c-Met and HGF/SF may contribute to tumour development by different means than those controlled by Her2/neu., Upregulation of hepatocyte growth factor plays a role in skin homeostasis after UV irradiation., Reduced levels of HGF are present in African Americans with systemic sclerosis., CREB activation, in concert with Sp1, constitutes a molecular switch that confers the cell type-specific induction of SnoN in response to HGF stimulation, HGF signaling process from Gab1 to PI3K is negatively regulated by PKC-betaII, and its loss is critical for melanoma cells to gain invasive potential., No significant SNP or haplotypic associations were observed for TGFbeta1 or hepatocyte growth factor in autism, CD44 is an important regulator of HGF/c-Met-mediated in vitro and in vivo barrier enhancement, a process with essential involvement of Tiam1, Rac1, dynamin 2, and cortactin., Irradiation enhanced HGF secretion in all 3 tested glioma cell lines (up to 7 times basal levels), Data suggest that HGF-induced effects in some mesothelioma cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway, HGF and IL-6 levels in combination with prostate volume were shown to be useful parameters for prostate cancer screening in patients with gray-zone PSA levels., Transduced adipose-derived stem/stromal cells secrete more than 80% less hepatocyte growth factor, which leads to a reduced ability to promote survival, proliferation, and migration of mature and progenitor endothelial cells in vitro., In lung fibroblasts from white SSc patients, HGF down-regulates the accumulation of CTGF via MAPK/MMP-1 and NF-kappaB signaling pathways, whereas collagen down-regulation is mediated mainly by a MAPK/MMP-1-dependent pathway., Recombinant human hepatocyte growth factor suppresses collagen type II-induced T cell priming in mouse spleen and diminishes the severity and incidence of experimental arthritis with up-regulation of IL-10 and suppression of IL-17., These data indicate that HGF may play a role in cell proliferation processes occurring in thyroid glands affected by HT, probably under the regulation of the lymphoid infiltrate., The neuroprotection of HGF depend on ERK1/2 pathway, and, to a lesser extent, PI-3K/Akt pathway., human breast cells are a uniquely permissive environment for HGF transactivation by Src/Stat3 which may allow for the inappropriate activation of HGF transcription during the early stages of breast transformation, This study provides data confirming the role of HGF in wound healing. We have also demonstrated the aberrant expression of the HGF receptor cMet and activation inhibitors (HAI-1 and HAI-2) in chronic wounds., High expression of human hepatocyte growth factor (HGF) is observed in myocardium through intracoronary gene transfection; HGF can improve mobilization of CD117+/c-Met+ stem cells into ischemic myocardium., HGF and c-MET are potential orchestrators of invasive growth in head and neck squamous cell carcinoma [review], This study was designed to investigate the roles of HGF/c-Met in tumor progression and metastasis in HepG2 and Hep3B hepatoma cell lines, These results suggest that coupling of Grb2 to Gab1 mediates the hepatocyte growth factor-induced strong activation of the ERK pathway, which is required for the inhibition of HepG2 cell proliferation., ERK activation with some other pathway(s), activated through the HGF receptor, are required to up-regulate p16 and p21 expression, that of p21 contributes to suppression of Cdk2 activity leading to inhibition of proliferation of HGF-treated HepG2 cells., HGF expression level in lymphocytes after liver transplantation may yield valuable information for evaluation of early graft function., Co-expression of HGF and c-Met in gastric cancer may promote the progression of gastric cancer., These results demonstrated that VPA inhibited two critical processes of tumor-stromal interaction, induction of fibroblastic HGF production and HGF-induced invasion of HepG2 cells., In medulloblastoma, HGF induces cell cycle progression, cell proliferation, apoptosis and increase in cell size in a c-Myc-dependent manner., HGF/c-Met were expressed in serum-starved ARPE-19 cells., IL-1beta is a main bronchoalveolar lavage fluid mediator involved in HGF secretion, which is mediated through a PGE(2)/COX-2-dependent mechanism., the ratio of HGF/TGF-beta1 may play a role in transient nephromegaly in children with Kawasaki disease, Might induce cisplatin resistance via c-Met to activate focal adhesion kinase and down-regulate apoptosis-inducing factor expression., Locally overexpressing hepatocyte growth factor prevents post-ischemic heart failure by inhibition of apoptosis via calcineurin-mediated pathway and angiogenesis, Stimulating human glioblastoma cells with recombinant HGF induces biologically relevant EGFR activation., we speculate that immediate increase of portal pressure, reflecting sinusoidal tensile/shear stress, accelerates liver regeneration through immediate induction of IL-6 and HGF., The constitutive production of HGF by UCSRalpha/HGF-transfected RPMCs can improve peritoneal fibrosis resulting in an increase in peritoneal ultrafiltration volume., results provide evidence that putative genetic factors involved in regulation of HGF variation contribute also significantly to variation of the obesity and blood pressure, NK1 variants have no detectable agonistic activity on, behave as bona fide receptor antagonists by blocking cell migration and DNA synthesis in target cells and have strong prospects as therapeutics for human cancer., Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC., Hepatocyte growth factor-mediated migration of myeloma cells was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins., Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer., These results support a model whereby hepatocyte growth factor-stimulated cell migration also requires a cofilin phosphorylation step that is mediated by PAK4., maleic acid indirectly induced HGF expression from human dermal fibroblasts through activation of ERK and JNK; de novo protein synthesis is required for maleic acid-induced upregulation of HGF mRNA., analysis of the hepatocyte growth factor-binding site in the immunoglobulin-like region of Met, the HGF variants have the potential to become pharmaceutical drugs in the treatment of human, ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in vitro., HGF gene transfer in myocardial infarction caused a near complete recovery of ejection fraction and improved the radial and circumferential ventricular strain., identification of HGF/MET mutations in primary lymphedema, lymphedema/lymphangiectasia, and breast cancer-associated secondary lymphedema suggests that the HGF/MET pathway is causal or alters susceptibility for a broad range of lymphedema phenotypes, assessment of binding of HGF to antibodies, receptors, and the basement membrane and identified binding interactions that are indispensable for the biological activity of HGF, the HGF/c-MET axis has a role in guiding stem cells toward brain injury, the activated form of HGFA is present at high levels in serum and bone marrow of myeloma patients, thus providing a necessary prerequisite for the activation of HGF., Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha, Hepatocyte growth factor inhibits VEGF-FOXO1-dependent gene expression in endothelial cells., A direct role for HGF in the invasive phenotype and motility of nasopharyngeal cancer cells was shown., analysis of HGF-stimulated cell scattering, HGF and c-Met have roles in growth of aggressive adult T-cell leukemia/lymphoma cells, HGF and EGF can interfere with CD95-mediated apoptosis and the action of cytotoxic T-cells through multiple mechanisms in human hepatocytes, transgene expression by transplanted mesenchymal stromal cells, in combination with granulocyte colony-stimulating factor administration, results in a synergistic therapeutic benefit in a rat model of miocardial infarction, Steric hindrance of the interaction between HGF beta domain binding to Met is sufficient for inhibiting full-length HGF-dependent Met signaling and cell migration., Stabilization of HGF mRNA by hypoxia is mediated, at least in part, by HIF-1., enhances trail-induced apoptosis in human medulloblastoma cells by up-regulating DR5, Preoperative plasma level of Hepatocyte growth factor/scatter factor is an independent predictor of prostate cancer metastasis to lymph nodes and disease recurrence after surgery, Carcinoembryogenic antigen-related cell adhesion molecule (CEACAM)-1 and the urokinase plasminogen activator (uPA)/uPA-receptor (uPAR) pathway were identified as possible mediators in HGF-induced keratinocyte migration., the proangiogenetic potential of growth factors may account for accelerated tumour growth when residual tumour cells are exposed to high levels of VEGF165 and HGF, TGFbeta1 and hepatocyte growth factor were major mediators of T-cell suppression by MSCs derived from ALL, HD and NHL, Serum levels of active hepatocyte growth factor may be a potential tumor marker for prostate cancer., Hepatocyte growth factor regulates the development of highly pure cultured chief cells from rat stomach by stimulating chief cell proliferation in vitro., as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3., Perinuclear translocation of c-Met is confirmed in hepatocyte growth factor (HGF)-stimulated cells; an increase in the amount of 50 kDa alpha-chain of c-Met is detected in HGF-stimulated cells., The study does not support the association of high myopia with alleles of rs2229336 in TGIF, rs3759223 in lumican, rs1982073 in TGFB1, and rs3735520 in HGF., an unexpected degree of flexibility in the GAG-HGF/SF interface, allowing a single binding site in the protein to accommodate iduronate-containing sequences of variable sulfation pattern and/or density from different GAGs., NmU may be involved in the HGF-c-Met paracrine loop regulating cell migration, invasiveness and dissemination of pancreatic ductal adenocarcinoma., Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes., elevated HGF is associated with insulin resistance and cardiovascular autonomic dysfunction in patients with type 2 diabetes mellitus not receiving insulin treatment, data suggest that hypoxia induces biosynthesis of PGF(2alpha), which then activates HGF and IL-8 expression. The results provide a reasonable explanation of how PGF(2alpha), HGF and IL-8 exert their effects on cancer cell metastasis, A regulatory element (DATE) located upstream from the transcription start site in the HGF promoter acts as a transcriptional repressor and is a target of deletion mutagenesis in human breast cancer, leading to constitutive activation of the HGF promoter., hepatocyte growth factor production is upregulated in human dermal fibroblasts by the extract of bitter melon pulp, circulating HGF demonstrated high heritabilities and a sexual dimorphism, Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor., Expression levels of HGF in circulating lymphocytes are not sufficiently specific to diagnose transitory postsurgical complications such as symptomatic infection after liver transplantation., Determine pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease., An enhanced activation of the signalling was observed when endothelial cells were stimulated by the combination of VEGF-A and HGF., the relatively infrequent expression of HGF and Met in Wilms' tumor tumorigenesis reflects their roles in nephrogenesis, particularly the mesenchymal-to-epithelial transition, rather than a dependence on oncogenic signaling pathways., SMYD3 has a role in regulation of c-Met expression and in cell migration and invasion induced by HGF, High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell HGF production or proliferation., Our findings reveal a novel pathway of HGF processing during skin repair, Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol., HGF-stimulated pathways propagate the anti-fibrotic effects in renal interstitial fibroblasts by repression of ECM production, in addition to down-regulation of various chemokines and members of the CCN family., The expressions of HGF and Hpa in laryngeal squamous cell carcinoma are higher than that in nonmalignant tissues, and correlate with lymph node metastasis, clinical stages and pathological grading., Serum HGF is increased in Hashimoto thyroiditis, especially associated to thyroid nodules, as compared with healthy non-goitrous individuals., Results show that blocking the HGF/c-Met pathway may be clinically useful for the treatment of HNSCC., This study supports a strong association between the mild to moderate myopia group and Hepatocyte growth factor (HGF) single nucleotide polymorphisms (SNPs)and HGF haplotypes., These results indicate that high concentrations of HGF in cerebrobspinal fluid occur in eosinophilic meningitis, and may have a role in protecting against endothelial injury and reducing blood brain barrier dysfunction., Study suggests that AFS cells acquire endothelial cell characteristics when stimulated by growth factors and shear force, and produce angiogenic factors (VEGF, PGF, and hepatocyte growth factor [HGF]) in response to hypoxia., Low-dose simultaneous delivery of adenovirus encoding hepatocyte growth factor and vascular endothelial growth factor in dogs enhances liver proliferation without systemic growth factor elevation., HGF has a direct effect on glioma cell proliferation and invasion. HGF up-regulates SDF-1 and CXCR4 mRNA expression and contributes to cell invasion., Asef and APC function downstream of HGF and PI3-kinase, and play critical roles in growth factor-mediated regulation of cell morphology and migration, Egr-1 might play an important role in the up-regulation of VEGF and IL-8 induced by HGF and contribute to HGF-mediated angiogenesis, which might be promising targets for hepatocellular carcinoma therapy., HGF and bFGF mRNA expression can be used as useful parameters to evaluate the prognosis of gastric cancer., polyphenols from tea decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit hepatocyte growth factor and vascular endothelial growth factor, the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, The expression of HGF, SP1 and VEGF are related to biological behavior of serosa-infiltrative gastric cancer., Overexpression of HGF is associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deletion of Hgf is associated with more general dysplasia., Study reports the results of a mutation screen for the autosomal-recessive nonsyndromic hearing loss locus DFNB39 and and found three mutations clustered in intron 4 and exon 5 in the hepatocyte growth factor gene (HGF)., HGF increased the motogenesis and invasiveness of hepatoblasts, but not of human adult hepatocytes, via phosphorylation of extracellular signal-regulated kinase (ERK) 1/2., HGF is a potent inhibitor of cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 through both autocrine and paracrine Epstein-Barr virus-independent pathways., Knockdown of PAK1 inhibits HGF-stimulated migration and loss of cell-cell junctions in DU145 prostate carcinoma cells, whereas knockdown of PAK2 enhances loss of cell-cell junctions and increases lamellipodium extension but does not affect migration., Hepatocyte growth factor differentially regulates drug transporter expression in hepatocytes., Elevated hepatocyte growth factor is associated with neuroblastoma., novel cross talk occurs between tumor necrosis factor receptor and TGF-alpha/epidermal growth factor receptor in stimulating human bone marrow mesenchymal stem cell hepatocyte growth factor production, Report negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells., a novel signaling pathway inhibits hepatic gluconeogenesis through HGF/AMPK/USF-1/SHP, HGF protects endothelial cells against gamma ray irradiation-induced damage., Induction of UGT1A1 and CYP2B6 by HGF in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity, Using lung adenocarcinoma samples and cell lines derived from lung adenocarcinomas, we demonstrated that the gene copy number for MET in lung adenocarcinoma tissue samples was increased over EGFR, HGF, and PXN and that it correlated with better prognosis, HGF inhibited TGF-beta1 mRNA expression and reduced collagen III secretion., apoptosis initiates chemoattraction of mesenchymal stem cells via the HGF/c-Met axis, thereby linking tissue damage to the recruitment of cells with regenerative potential., HGF is a very early, good marker of myocardial necrosis and a sensitive short- and long-term prognostic factor in acute coronary syndrome., Co-operating with IL-8, HGF might contribute to a poor prognosis of nasopharyngeal carcinoma by inducing angiogenesis through both autocrine and paracrine EBV-independent pathways, HGF is a potential downregulator of TSP-1, through MAPK signaling pathways, leading to the induction of MMP-9 expression and subsequent invasion of SKOV-3 ovarian cancer cells., Demonstrate the potential of trimethylene carbonate-based elastomers combined with an osmotic mechanism to release recombinant HGF., These findings present the HGF gene as the first gene significantly associated with hypermetropia as well as providing evidence of significant association with myopia., Myostatin expression and secretion were significantly upregulated in proliferating satellite cells in response to high concentrations of HGF which may reestablish quiescence., HGF is activated by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA., Results provide evidence that autocrine overactivation of the Met- HGF loop enhances systemic metastases in NSCLC, G-CSF-mediated hematopoietic stem/progenitor cells (HSPC) mobilization occurs in part through the HGF/c-Met axis in HSPC and myeloid cells, eliciting increased production of matrix-degrading enzymes and subsequently facilitating egress of HSPC., Uveal melanomas express HGF, c-Met, EGFR, and IGF-1R, This study suggests that natural variation within HGF is involved in the control of retinal arteriolar diameter and may be important in the pathogenesis of microvascular disease in individuals of Chinese descent., MET activation by its ligand, HGF, also induces drug resistance, High HGF expression was associated with advanced clinical stage, lymph node metastasis in nasopharyngeal carcinoma., High hgf expression is associated with lung adenocarcinoma., Co-treatment with HGF and TGF-beta1 enhances keratinocyte migration, accompanied with reactive oxygen species generation through NADPH oxidase, involving Nox-1 and Nox-4 isozymes., The cross-talk and balance between HGF/c-Met signal pathways are critical and necessary in the development of new therapies for lung cancer., circulating HGF is a potential laboratory marker reflecting coagulation activity and DIC prognosis in non-cancer patients and HGF may play a role in a vicious cycle of hypercoagulability., HGF and c-Met are widely expressed in pituitary adenomas and may have a role in their angiogenesis and tumorigenesis, Study describes a model that stroma-derived HGF and hyaluronan influence androgen receptor and CD44 functions in the secretory epithelia during prostate carcinogenesis., Circulating levels of hepatocyte growth factor are associated with increased risk of incident ischemic stroke, independent of obesity and other cardiovascular risk factors, among postmenopasal women aged 50 to 79 years., Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation, These results indicate that increased serum HGF levels might be a requirement for antidepressant efficacy in patients with panic disorders., HGF levels are associated with the presence of type 2 diabetes in postmenopausal women., TNF-alpha can enhance human MSCs migration and stimulate their production of HGF. These effects are mediated via a specific TNF receptor and signaling pathways., Genetic modifications of both HGF in fibroblasts and its receptor Met in epithelial cells underscore the importance of this pathway in esophageal squamous cell carcinoma invasion and progression., simultaneous expression of HGF/c-met and three trasducers of tyrosine kinase receptors STAT3, PI3K, RHO in both nodular and extranodular tissues were studied by immunohistochemistry in 50 benign thyroid nodules, 25 associated with Hashimoto's thyroiditis, Activated platelet rich plasma contains HGF which inhibits NF-kappaB activity to prevent inflammation., Immunohistochemistry in muscle from polymyositis and dermatomyositis patients revealed that HGF was expressed predominantly on infiltrating mononuclear cells and that muscle cells expressed the receptor c-met., molecular mechanism of the interactions between the oligosaccharides and pleiotrophin, Results indicate that c-Met/HGF pathway may be a potential target for therapeutic intervention for treatment of EOC., These results demonstrate that, in the cell lines that we used, CD44 receptors play no role in the activation of c-Met, neither during Listeria monocytogenes entry via the function of inlB, nor upon HGF activation., Established a Tet-regulated human HGF gene expression system in NRK52E (rat kidney tubular epithelial) cells., these findings reveal a novel pathway for regulating HGF signaling to the Par proteins through Erk-cdGAP, resulting in tight junction disassembly and cell scattering., In patients with chronic rhinosinusitis with nasal polyps, epithelial cells are resistant to Th2-response downregulation by HGF, a moderate expression of HGF in the lamina propria of the human vocal fold and in the basal membrane of the mucosal epithelium, Smad2 loss causes HGF upregulation via loss of Smad2-mediated transcriptional repression and enhanced Smad3/4-mediated transactivation., Transplantation of HGF gene-modified bone marrow stromal cells (MSCs) induces powerful neuroprotection on rabbit spinal cords against ischemia-reperfusion injury and is therapeutically more efficient than transplantation of MSCs only., Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling., results suggest that TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by HAI-1, HGF/c-Met is critical for beta-cell survival by attenuating NF-kappaB signaling and suggest that activation of the HGF/c-Met signaling pathway represents a novel strategy for enhancing beta-cell protection., HGF and IL-11 are upregulated in Polycythemia vera and their overproduction is not a consequence of JAK2V617F, These results suggest that the growth factors HGF and KGF may play a role in enhancing IL-1-stimulated production of IL-8 by epithelial cells during mucosal inflammations., a novel mechanism driving the HGF pathway whereby heparanase stimulates an increase in both HGF expression and syndecan-1 shedding to enhance HGF signaling., HGF-induced inhibition of fibrotic remodeling may occur via multiple direct and indirect mechanisms including the induction of cell survival and proliferation of pulmonary epithelial and endothelial cells, and the reduction of myofibroblast accumulation., HGF and c-Met may play a role in the progression of endometrial cancer, Intramuscular injection of naked HGF plasmid is safe and feasible and can achieve successful improvement of ischemic limbs as sole therapy., the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF, HGF is associated with proteinuria and renal pathological changes in children with Henoch-Schonlein purpura., Taken together, it is suggested that human HGF controls and interacts with the promoter region of the Sub2 gene of Plasmodium falciparum., breast cancer cells could alter the nature of its surrounding fibroblasts to secrete HGF to support its own progression through paracrine signaling., HGF protects podocytes from a loss of nephrin, at least in part, through maintaining synaptopodin in nephritic mice with albuminuria., Plasma levels of HGF predict joint damage in rheumatoid arthritis, and this finding suggests that HGF plays a role in RA joint destruction., Through activating the Dll4-Notch-Hey2 signaling pathway, HGF indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed., Soluble CD30 and Hepatocyte growth factor as predictive markers of antibody-mediated rejection of the kidney allograft., Elevated serum HGF and VEGF levels predict a more aggressive biological behavior in laryngeal squamous cell cancer., Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens., Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue, HGF autocrine signaling is not responsible for EGFR-induced c-Met phosphorylation, Hepatocyte growth factor gene therapy is safe and effective for critical limb ischemia in patients with Buerger's disease., low plasma levels are associated with higher response rate to gefitinib in patients with advanced non-small cell lung cancer, Expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer., HGF promotes the expression of sphingosine-1-phosphate and the invasion ability of pancreatic cancer cells, chronic lymphocytic leukemic cells express a functional hepatocyte growth factor receptor (c-MET) and hepatocyte growth factor enhanced the viability of these cells through STAT3 phosphorylation, A single nucleotide polymorphism in the HGF promoter region may modulate the severity of interstitial lung disease by controlling the transcriptional efficiency of the HGF gene., dose dependently induced tubular structures in human renal proximal tubular epithelial cells cultured in gels, HGF is a strong and independent predictor of mortality in advanced heart failure and, in particular, in ischaemic heart failure., Atorvastatin decreases HGF levels in patients with coronary artery disease, possibly contributing to its beneficial effects., Data show that miR-198 targets c-MET via its 3'UTR, and that forced expression of miR-198 decreased c-MET expression and diminished HGF-induced phosphorylation of p44/42 MAPK., Transendocardial delivery of HGF is safe and may help to preserve microcirculatory perfusion and improve wall motion in a pig model., In a porcine model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/HGF is a practical and effective strategy to reduce pathological cardiac remodeling., PDGFBB and HGF are related to severity of acute pancreatitis, and together with Ang-2 are related to clinical evolution., Our findings highlight the function of the NK1 splice variant of hepatocyte growth factor in non-tumorigenic human prostatic epithelial cells and provide a picture of the signaling pathways triggered by NK1, HGF-positive serum status had a significant and independent negative effect on progression-free survival among patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib and having the wild-type EGFR gene., These data demonstrate that GAB1 is ubiquitinated by CBL and degraded by the proteasome, and plays a role in negative-feedback regulation of HGF/SF-MET signaling., a novel role for Btk in HGF-induced DC inhibition., We demonstrated that the HGF/c-Met pathway induces EMT and inhibition of anoikis in gastric cancer cells. Co-expression of HGF and c-Met has the potential to promote peritoneal dissemination in gastric cancer, suggest that abnormality of the HGF/MET pathway occurs during the course of progression from non-invasive to invasive pulmonary adenocarcinoma, Genetic variation in hepatocyte growth factor (HGF) is associated with primary angle closure glaucoma in the Nepalese population., results suggest that miR-200c and miR-27b downregulated by HGF might play an important role for EMT and ECM degradation with HGF autoactivation followed by enhanced invasive characteristics of squamous cell carcinoma of the head and neck, HGF induces vascular smooth muscle cell osteogenic differentiation via c-Met/Akt/Notch3 signalling, highlighting these pathways as potential targets for intervention of vascular calcification., Elevated cancer cell cMET and stromal HGF expression were significantly associated with a worse prognosis, promotes the proliferation of eccrine sweat gland epithelial cells, which is relative to AKT signal channel and beta-catenin, Taken together, these results implicate genetic variation at the HGF locus with keratoconus susceptibility., Bortezomib can down-regulate HGF mRNA expression and inhibit the migration of bone marrow mesenchymal stem cells in multiple myeloma patients., Immunohistochemical characterization of HGF/C-MET system pathways in benign and malignant histotypes of thyroid nodules., Abnormal expression of HGF and TSP-1 may be related to malignant progression of ovarian cancer and associated in the pathogenesis of ovarian cancer., The expression of ezrin, HGF and/or c-met might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma., Protein engineered variants of hepatocyte growth factor/scatter factor promote proliferation of primary human hepatocytes and in rodent liver., Serum HGF levels may serve as a biomarker for the presence of autocrine tumors and their responsiveness to MET therapeutics., HGF induced functional CXCR4 receptor expression in breast cancer cells. The effect of HGF was specifically mediated by PKCzeta activity., up-regulation of JunB induced by HGF might play an important role in the regulation of cell proliferation and cell invasion through MMP-9 expression., Expression of c-Met is one of the factors that distinguishes normal from malignant plasma cells and indicates that the HGF/c-Met system is activated in multiple myeloma patients., It is suggested that CAFs can promote MCF-7 migration and invasion through HGF in vitro., Perturbations in gene expression of TIMP-1, MMP-1 and HGF were evident in both affected and unaffected skin of the systemic scleroderma patients., HGF is a biomarker and mediator in cardioprotection and cardiovascular regeneration [review], The HGF-beta.mannose receptor complex may provide a new pathway for the enhancement of cell clearance systems, which is associated with resolution of inflammation., Hepatocyte growth factor reduced cardiac fibrosis by inhibiting endothelial-mesenchymal transition and the transformation of fibroblasts into myofibroblasts., HGF strongly and dose dependently induced cell migration. Cell migration was dependent on the two MAP kinase pathways that proceed through MEKERK and p38, respectively, as well as the PI-3 kinase pathway., In a spinocerebellar ataxia type 7 transgenic mouse model, overexpression of HGF attenuates degeneration of Purkinje cells and Bergmann glia., Studies indicate that EGFR signaling in EGFR-mutant lung cancer and hepatocyte growth factor (HGF) ligand-triggered bypass signals (HGF-Met and EGFR ligands-EGFR) must be simultaneously blocked to avoid the resistance., findings suggest that transcriptional activation of LEF1 is a mechanism of cross talk between HGF/c-Met and Wnt/beta-catenin pathways and is essential for HGF-induced tumor invasion, The findings indicate that in vivo exposure to apoptotic cells enhances transcriptional HGF production in bleomycin-stimulated lungs, resulting in attenuation of lung injury and fibrosis., To determine if mutation of HGF/MET pathway genes is a mechanism for pathway dysregulation, conducted a mutational analysis of three key components of this pathway, The HGF/c-Met signaling pathway may be involved in the pathogenesis and progression of colon cancer., The A allele of HGF rs3735520 was associated with longer vitreous chamber depth in a cohort of Chinese patients with myopia., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., In hepatocellular carcinoma cells, up-regulation of HDAC1-3 reduces expression of miR-449, activating hepatocyte growth factor and altering tumor growth., The interaction between HGF and c-Met increases OPN expression in human osteoblasts via the PI3K, Akt, c-Src, c-Jun, and AP-1 signaling pathway., HGF down-regulated c-Met receptor expression, whereas it up-regulated pro- and active/mature forms of ADAM10 and ADAM17 expression, which resulted in enhanced sMet production, HGF alters the subcellular localization of zonula occludens ZO-1, The abnormal expression of FSCN1 and HGF in the inferior turbinate may be closely correlated with nasal inverted papilloma and its malignant process., There was significant correlation among tumor cell-derived HGF, cell proliferation and microvessel proliferation in gliomas. HGF might influence tumor progression by modulating the cell growth, migration and chemoresistance to drugs., Cell-specific expression of hepatocyte growth factor leads to remodeling of the connective tissue within the septal walls of the lung., Results indicate that polymyxin B (PMB)-induced hepatocyte growth factor (HGF) production and proliferation of human dermal fibroblasts and suggest that activation of mitogen-activated protein kinases is involved in the induction of HGF production., stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signalling pathways, and immediate resistance to RAF inhibition in BRAF-mutant melanoma, There was decreased expression of hepatocyte growth factor in CSF cells as well as reduced CSF but not plasma HGF levels in multiple sclerosis patients. Patients with active disease had lower hepatocyte growth factor CSF levels than inactive disease., Data suggest that elevated serum hepatocyte growth factor (HGF) levels were significantly associated with the development of insulin resistance (IR)., Overview of HGF function and effects on epithelial and endothelial cells, proangiogenic effect, and antifibrotic properties. Modulation of HGF may be an attractive target for the treatment of lung fibrosis., levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy, a potential association between the CYP19A1 variants and circulating HGF levels, High GCNs of MET and HGF associate with an increased risk of trastuzumab-based therapy failure in HER2-positive MBC., We conclude that KLF4 upregulation by HGF represents a novel mechanism mediating HGF-induced cell scattering and perhaps other associated events such as cell migration and invasion, Enhanced cell replication through increased KLF6 alternative splicing is a novel growth-promoting pathway of HGF that could contribute to the molecule's mitogenic activity in physiologic liver growth and hepatocellular carcinoma., Data show that that mesenchymal stem cells (MSCs) cultured in hypoxia were superior to those cultured in normoxia in inducing expression of both HGF (hepatocyte growth factor) and VEGF (vascular endothelial growth factor) in the cultured medium., study indicated that JNK and P38 MAPK pathways are required in HGF-induced biological responses in hDPCs, an anti-apoptotic role of caspase-cleaved GAB1 in HGF/SF-MET signaling., HGF regulated Src homology domain 2-containing inositol 5'-phosphatase 2 recruitment to EGFR and inhibited LPS-induced inflammation via EGFR degradation., Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis., Data suggest that HLX1 (H2.0-like homeo box 1) is downstream mediator of HGF-induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development., The binding ability of mouse HGF alpha-chain, or of beta-chain, to human c-Met was lower than that of human HGF., we show for the first time that HGF-induced EGFR tyrosine kinase-inhibition is a very common mechanism in human cancers, Establish a pharmacokinetic model applicable to HGF administration in animals/humans., Met kinetic signature derived from the response to HGF/SF in a cellular model predicts breast cancer patient survival, HGF is upregulated in POEMS syndrome. Elevation of HGF levels is not secondary to VEGF overproduction., Asc-2P increases the proliferation of cultured HCECs through upregulation of HGF production via an HGF/c-Met autocrine loop., The absence of HGF and c-Met polymorphisms in our study groups suggests that polymorphisms in the minimal promoters of these genes are not involved in the pathogenesis of ROP., MET dimerization by the HGF splice variant NK1 may be ligand-mediated with a NK1 dimer at the center of the 2, Targeted HGF gene transfer specifically to alveolar type II epithelial cells decreases bleomycin-induced lung fibrosis and may therefore represent a novel cell-specific gene transfer technology to treat pulmonary fibrosis., The show that restoration of F508del-CFTR PM localization by correctors can be dramatically improved through a novel pathway involving stimulation of signaling by the endogenous small GTPase Rac1 via hepatocyte growth factor (HGF)., High hepatocyte growth factor is associated with renal cell carcinoma progression., S1PR1 and ITGB4 transactivation are rate-limiting events in the transduction of HGF signals via a dynamic c-Met complex resulting in enhanced EC barrier integrity, HGF is important in the repair of the dentine-pulp complex potentially participating in several aspects of wound healing., Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of HGF., Studies indicate that NK4 hepatocyte growth factor fragement inhibits hepatocyte growth factor (HGF)-mediated hepatocyte growth factor receptor MET tyrosine phosphorylation by competing with HGF for binding to MET., NK4 has anti-proliferative and anti-invasive effects in cholanciocarcinoma mediated the HGF/Met pathway., HGF enhances migration of chondrosarcoma cells by increasing matrix metalloproteinase-2 expression through the c-Met receptor/PI3K/Akt/PKCdelta/NF-kappaB signal transduction pathway., HGF-induced Met phosphorylation may be an important mechanism of gefitinib resistance in sensitive non-small cell lung cancer, glioblastoma cells express HGF, which contributes to the attraction of mesenchymal stem cells., Suppression of STAT3 phosphorylation with WP1193 reduced HGF expression in DeltaEGFR-expressing GBM cells., We found that HGF coexpression is a key predictor of response to c-MET inhibition among the examined factors and identified an ERK/JAK/p53 pathway activation signature that differentiates c-MET inhibition in responsive and nonresponsive cells, Hepatocyte growth factor inhibits both activation and tumor-promoting properties of cancer-associated fibroblasts., HGF expression is higher in advanced versus no/limited multiple myeloma lytic bone disease. The full-length HGF variant is specifically up-regulated in LBD. NK1&-2 isoforms are produced at 'background' levels., the hHGF lentiviral vector was successfully generated, and the lentiviral vector was able to safely infect hADSCs with high infection efficiency, thereby producing cells that overexpressed hHGF, HGF transfection suppresses PAH induced by shunt flow through enhanced expression of HGF with subsequent regulation of the concentrations of eNOS and ET-1 secreted by endothelial cells thereby promoting angiogenesis in injured lung tissue., HGF synergized with SDF-1 to cause concentration gradient-directed migration of multiple myeloma cells., HGF and Met may exert functions in the development of Synchronous liver metastasis when concurrent with lymph node metastases but had little influence on SLM without lymph node metastasis, We have shown that elevated cHGF can consistently and reproducibly be measured as a pharmacodynamic biomarker of onartuzumab activity., ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma, HGF rs5745718 and rs17427817 are associated with a decreased risk of primary angle-closure glaucoma in the Chinese Han population., HGF is distinctly regulated at the posttranscriptional level from its antagonist isoform, NK2, via microRNA-199., HGF plays a key role in hepatocellular carcinoma proliferation induced by hepatocellular carcinoma-ancer-associated fibroblasts., HGF and SDF-1 are required for effective mobilization and homing of CD133+ hematopoietic stem cells to the liver after hepatic resection., mesenchymal stem cells derived from human umbilical cord have the ability to differentiate into dopaminergic neurons after transduction with adenoviral vector expressing HGF., GM3 ganglioside promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling., Human macrophages promote epithelial repair through the production of HGF; macrophages from Chrohn's disease (CD) patients have impaired epithelial repair properties owing, at least in part, to defective HGF production., Data indicate that binding between hepatocyte growth factor (HGF)-alhpa and tyrosine kinase MET was disrupted by onartuzumab., increased tumor c-MET and HGF expressions were associated with favorable disease attributes but not with survival., increased blood concentrations of biomarkers VCAM-1, soluble Fas and hepatocyte growth factor, separately and in combination, associate with mortality among the aged and are prognostic markers of death, The levels of GRP, Ets-1, and IL-8 were upregulated in cells treated with HGF in a dose-dependent manner., Overexpressed TNF- alpha and HGF in microenvironment were related to poor differentiation and microvascular invasion of hepatocellular carcinoma (HCC)., a mechanism whereby HSCs modulate the chemoresistance of hepatoma cells, Coordinated and complementary changes in HGF/MET expression occur in epithelium and stroma during progression of pre-invasive basal-like lesions., Data supports the strong immunomodulatory nature of Mesenchymal stromal cells and demonstrate the role of HGF, a mitogenic molecule, in the expansion of myeloid-derived suppressor cells., HGF inhibits apoptosis of pancreatic beta cells., suggests that binding of the HGF variants to the cell surface c-Met resulted in the downregulation of MMP-9, and upregulation of MMP-8 protein expressions might be key molecular signals against proliferation, migration, and invasion of A549 cells, Our results strongly suggest that paracrine HGF-induced activation of MET-mediated signaling pathways plays an important role in the pathogenesis of peritoneal carcinomatosis in scirrhous gastric cancer., While EGF activated Gab1 and Shc equally, within the same concentration range, HGF very potently and almost exclusively activated Gab1, having only a minimal effect on Shc, Despite serum HGF levels were found diagnostic value, serum HGF levels had no prognostic value in patients with Hepatocellular carcinoma, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells., these results demonstrate that HGF/c-Met plays an important role in obesity-associated carcinogenesis., Studies suggest that although serum proto-oncogene proteins c-met (MET) and hepatocyte growth factor (HGF) may serve as predictive biomarkers for MET therapeutics, data do not support their use as pharmacodynamic biomarkers for onartuzumab., miR-26a could suppress tumor angiogenesis of hepatocellular carcinoma (HCC) through HGF-cMet signaling., HGF-incorporated gelatin hydrogel sheet can be a new therapeutic modality for autoimmune myocarditis., In conclusion, HGF may be associated with the prognosis of patients who undergo radical cystectomy, and the HGF DATE may affect the risk and aggressiveness of bladder cancer by altering HGF expression., These findings provide additional evidence of significant association of the HGF gene with Keratoconus., Sustained effect of KGF on cell survival and proliferation could be attributed to its ability to inhibit p53, retinoblastoma, caspases, and p27(kip) functions in apoptosis and cell cycle arrest., Melanoma specimens with extensive clinical annotation failed to validate HGF immunohistochemistry as a predictor of response to BRAF inhibitors., Dock7 mediates serum- and HGF-induced glioblastoma cell invasion., Upregulation of HGF is associated with subclinical central lymph node metastasis in papillary thyroid microcarcinoma., Data show bone marrow-derived mesenchymal stem cells (MSCs) expressing NK4 (N-terminal and the subsequent four kringle domains of hepatocyte growth factor) strongly inhibited proliferation and migration of the pancreatic cancer cell line after co-culture., findings indicated that miR-199a-3p target HGF/c-Met signaling pathway which is crucial for renal cell carcinoma (RCC) development and suggest that miR-199a-3p may serve as a potential target miRNA for RCC therapy, these data provide evidence in support of a significant role for HGF-induced c-Met/PI3k/Akt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial cells., Differential roles for p38alpha and p38beta in the HGF-induced expression of key osteogenic markers., Hgf as an important transactivator of canonical Wnt signaling that is mediated by Met-stimulated, Gsk3-dependent Lrp5/6 phosphorylation, HGFs modulate IL-10 production in monocytes through the ERK1/2 pathway., results suggested that genetic variants in ACAN and MET are associated with HM. Functional roles of ACAN and MET in the development of HM need to be further investigated, HGF and TGF-beta are critical regulators for both tumor-stroma interaction and tumor invasion., induction of HGF synthesis via RNA transferred by microvesicles activating AKT and ERK1/2 signaling is a crucial contributor to the pro-tumor effect, Plasma HGF and EREG levels are associated with resistance to treatment with anti-EGFR antibodies in KRAS wild-type patients with metastatic colorectal cancer., HGF may be a potential prognostic marker in HPV-negative tonsillar squamous cell carcinoma, selected 68 different antibodies that compete with HGF for binding to MET. HGF-competing antibodies recognized 4 distinct hotspots localized in different MET domains, Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia., HGF upregulation contributes to wound repair and epithelial proliferation in macrophages., Data indicate that both hepatocyte growth factor (HGF) and hepatocyte growth factor receptor c-Met are increased after NACT (Neo Adjuvant Chemotherapy)., upregulation of the COX-2/PGE2 and HGF in macrophages following exposure to apoptotic cells represents a mechanism for mediating the anti-inflammatory and antifibrotic consequences of apoptotic cell recognition, The serum VEGF, SIL-2R and HGF contents in 81 patients., Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF and BMP-7., Studies show that IQGAP1 functions as a hub linking HGF-induced signaling to microtubules and actin remodeling via EB1-IQGAP1-cortactin interactions., Single nucleotide polymorphism in HGF (rs5745752) is significantly associated with breast cancer risk., In the presence of high HGF, dual inhibition of c-Met and COX-2 may enhance antitumor effects. This combination may have clinical potential in NSCLCs with high HGF/c-Met expression or epithelial-mesenchymal transition phenotype., Serum hepatocyte growth factor (HGF) was measured and studied in patients with glioma in regards to the response to radiotherapy and disease-free survival., These data demonstrate, that in addition to microtubule-independent Tiam1 activation, HGF engages additional microtubule- and APC-dependent pathway of Asef activation., This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role., results demonstrate a novel MT-dependent mechanism of HGF-induced EC barrier regulation via Rac1/PAK1/stathmin-dependent control of MT dynamics, An autocrine HGF/cMET loop sustains multiple myeloma angiogenesis and represents an appealing new target to potentiate the antiangiogenic management of patients with multiple myeloma., Disruption of deoxyadenosine tract element increased HGF signaling via MET and reduced levels of RIPKI1 and colorectal cancer cell necroptosis., Blood Hepatocyte growth factor did not differ significantly between patients with chronic viral hepatitis C and controls., Hepatocyte growth factor was highly expressed in breast cancer cells and was closely associated with lymph node metastasis, prognosis and sensitivity to chemotherapy., Data show that Ash1l and EZH2 methyltransferases protein expression was significantly elevated in fibrotic liver and decreased in mutant matrix metalloproteinase-9 (mMMP-9) and human hepatocyte growth factor (hHGF) gene transfer treated fibrotic livers., Findings indicate that SHIP2 is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 gene may act in concert with HGF, and likely MAP3K7, mutations to exacerbate lymphatic phenotypes., HGF mediated resistance to alectinib, but not to crizotinib, via the MET signal, that alectinib activated the MET signal in ALK-positive non-small cell lung cancer., expression of HGFalpha or cMet was closely correlated with VEGFC, lymphatic microvessel density and metastases of lymph nodes, indicating HGFalpha, cMet and VEGFC may perform important and collaborative actions in lymphangiogenesis and lymphatic metastasis of primary non-small-cell lung cancer, HGF signaling through c-Met may decrease inflammation in endothelial cells and protect against intracranial aneurysm rupture., these results demonstrate potent anti-inflammatory effects by HGF and delineate a key role of Asef in the mediation of the HGF barrier protective and anti-inflammatory effects., A direct link between expression of HGF and biochemical prostate cancer recurrence after radical prostatectomy., Genetic variation contributes to the interindividual variation in growth factor levels and explains a modest proportion of circulating hepatocyte growth factor, Ang-2, and Tie-2., These results suggested that the expression of the HGF/cMet pathway in gastric cancer may be a potential predictive factor for disease progression., This is the first report that primary cancer-associated colonic fibroblasts activated by HGF play a critical role in mediation of proliferation and invasiveness of human colonic epithelial cancer cells., MACC1 overexpression predicted worse prognosis after liver resection, which was attributed to the repression of HCC cell apoptosis via a molecular mechanism in which MACC1 accelerated the activation of the HGF/c-MET/PI3K/AKT pathway, Data suggest HGF is up-regulated in placenta/amniotic fluid of obese pregnant women as compared to normal-weight women; HGF may stimulate glucose uptake/metabolism, impair fatty acid oxidation, and enhance de novo fatty acid synthesis/esterification., hepatocyte growth factor has a role in differentiation potential of bone marrow-derived mesenchymal stem cells treated with L-ascorbic acid 2-phosphate and fibroblast growth factor-2, Evidence for association was found for both of the tested loci.It was strongest for rs3735520, These results demonstrate that endometrial carcinoma stromal cells stimulate epithelial cell proliferation via the HGF/c-Met/Akt signaling pathway., HGF induction is a crucial contributor to the acceleration of cell dedifferentiation and growth., evidence uncovered essential roles of CRK in invasive bladder cancer through the hepatocyte growth factor/c-Met/CRK feedback loop for epithelial-mesenchymal transition induction, Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Augment Sinonasal Wound Healing., Results show that MET and HGF overexpression were significantly correlated in undifferentiated pleomorphic sarcomas or angiosarcomas suggesting an autocrine activation. These proteins may be potential biomarkers fro these types of sarcoma., HGF produced by hAFSCs exerts a cytoprotective role, inducing an increase in caspase-dependent apoptosis in human immune cells., High HGF (and follistatin) expression in tumor tissue from esophageal cancer patients was associated with poor prognosis., Sequential and timely transfection of hepatocyte growth factor and monocyte chemotactic protein-1 ameliorates hyperkinetic pulmonary artery hypertension in rabbits., HGF level may be a new detection method used for the rapid diagnosis of benign and malignant SPNs., Based upon ethnicity-stratified single-variant association analysis and trans-ethnic meta-analysis of 6201 participants of the Multi-Ethnic Study of Atherosclerosis, discovered 5 common and low-frequency variants, Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling, HGF and TGFbeta1 of bone-metastasis microenvironment acted co-ordinately, influencing non redundant pathways regulated by Twist program or Snail-transcription factor, with reversible MET switch, Increased miR-16 expression promotes liver fibrosis through downregulation of HGF and Smad7 in hepatitis C patients., reduced serum level in kidney stone patients, relative to healthy subjects; no difference in allele frequency, In donors significantly lower levels of IL-6, TNF-alpha, HGF, and TGF-beta were detected in portal blood compared to hepatic vein In patients with cirrhosis there were no significant differences of IL-6, TNF-alpha, and TGF-beta levels between portal and hepatic veins, our work reveals a critical relationship of Cox-2/PGE2 and HGF/MET signaling in promoting glioma cells proliferation, HGF upregulates the expression of DNA methyltransferase 1 (DNMT1) in HEPG2 cells., Intramuscular injection of pUDK-HGF is safe, and may provide symptomatic relief for critical limb ischemia patients., The findings support a role for HGF in regulating both myoblast cell number and terminal differentiation., Data show that monoclonal antibody ARGX-111 inhibits hepatocyte growth factor (HGF)-dependent proto-oncogene protein c-met (MET) activity by competing with HGF for binding to MET., The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion, Direct binding of CD44v6 to HGF and VEGF was demonstrated in pull-down assays, Peptide HGP-1 could disrupt the activation of HGF/MET signaling to influence tumor cell activity., HGF/cMET signaling plays and important role in adrenocortical carcinoma growth and resistance to commonly used treatments., HGF and its receptor, cMET, are antagonized in human lung cancer cells treated with YangZheng XiaoJi, Case Report, study suggests that GPC3 is involved in HCC cell migration and motility through HS chain-mediated cooperation with the HGF/Met pathway, showing how HS targeting has potential therapeutic implications for liver cancer, HGF secreted by ovarian cancer cells induces the mesothelial-to-mesenchymal transition and stimulates the invasion of mesothelial cells. HGF secreted by ovarian cancer cells plays an important role in cancer peritoneal implantation., integrin alpha6beta4 stimulates invasion by promoting autocrine EGFR signaling through transcriptional up-regulation of key EGFR family members and by facilitating HGF-stimulated EGFR ligand secretion, Treatment of silicosis with HGF-expressed autologous bone marrow stromal cells has been reported., The signal transduction mechanisms in a gene interaction network describing hepatocyte growth factor-stimulated cell migration and proliferation from gene-expression measured with microarray, Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation., High serum HGF levels in breast cancer patients are associated with clinically detectable regional node metastasis and, paradoxically, with longer relapse-free survival in stage II/III breast cancer., we suggest that combinatorial therapeutic strategies with HGF and c-Met inhibitors comprise promising candidates for overcoming sorafenib resistance., these data demonstrate that FGF-2 priming enhances the angiogenic potential of SHED through the secretion of both HGF and VEGF., level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism, Pre-osteoblasts stimulate migration of breast cancer cells via the HGF/MET pathway., Report the application of advanced quantitative fluorescence microscopy techniques to study changes in the oligomerization state of the RTK Met in response to stimulation by its endogenous ligand hepatocyte growth factor.,
OFFICIAL_GENE_SYMBOL HGF,
OMIM_DISEASE Deafness, autosomal recessive 39,
SP_COMMENT function:HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity., online information:Hepatocyte growth factor entry, similarity:Belongs to the peptidase S1 family. Plasminogen subfamily., similarity:Contains 1 PAN domain., similarity:Contains 1 peptidase S1 domain., similarity:Contains 4 kringle domains., subunit:Dimer of an alpha chain and a beta chain linked by a disulfide bond.,
integrin subunit alpha 5(ITGA5) integrin subunit alpha 5(ITGA5) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q11-q13,
ENSEMBL_GENE_ID ENSG00000161638,
GENERIF_SUMMARY alternative pathway of pro-alpha(v) processing involving MT1-MMP, The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits., role in mediating adhesion and migration of activated cycling CD34+ hematopoietic progenitor cells onto fibronectin, Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast, Central role of alpha5beta1 integrin in vascular development in mouse embryos and embryoid bodies., TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression, The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro., results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., B. pertussis FHA up-regulates ICAM-1 expression on respiratory epithelial cells through interaction of its RGD site with host cell VLA-5 integrin, and that PT impairs this response, Elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton., integrin alpha5beta1 extracellular domain controls rhoA activity, Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, identification of binding site in gamma C-domain of fibrinogen, alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, The structural conformation of this protein, complexed wigh integrin beta1, complexed with fibronectin, is examined., Disulfide bonding patterns of the integrin alpha 5 chain are demonstrated; new insights into a second bond between the heavy and light chains of alpha 5 are described., Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., The integrin, alpha 5 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., the alpha5 integrin subunit has a role in the induction of apoptosis triggered by FGFR2 activation in osteoblasts, and a Cbl-dependent mechanism is involved in the coordinated regulation of cell apoptosis induced by alpha5 integrin degradation, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, alpha3, alpha5, and alpha6 beta1 integrins are expressed in ductal cells at 8 weeks, before glucagon- and insulin-immunoreactive cells bud off in fetal pancrea., ITGA5 mediates engraftment of GCSF-mobilized stem cells., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, one mechanism by which IGFBP2 activates IGFBP2-induced cell mobility is through its interaction with integrin alpha5 and this interaction is specifically mediated through the RGD domain on IGFBP2, binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins, Alpha5beta1 (VLA-5) integrin is a major galectin-1-glycosylated counterreceptor involved in immune developmental synapse formation., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, activities for cell spreading and migration for the alpha5 subunit carrying only three potential N-glycosylation sites (3-5 sites) on the beta-propeller were comparable with those of the wild type, integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., surface micron-scale topography modulates alpha(5)beta(1) integrin binding and FAK activation, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Interaction of alpha-toxin with alpha5beta1-integrin and overproduction of TNF-alpha may contribute to destruction of epithelial cells during S. aureus infection., Modulation of cell adhesion is a normal physiological action of PTHrP, mediated by increasing integrin gene transcription., This study identified the beta1 integrins on primary smooth muscle cells that fibulin-5 interacts with, and showed that failure of fibulin-5 to activate these receptors limits cell spreading, migration and proliferation., OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest possible participation of alpha5beta1 integrin in the mechanism of local invasion of ameloblastomas, KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta, There is low expression of the proteins and mRNA of ME491/CD63 and integrin alpha5 in ovarian cancer. The lower the pathological differentiation is, the more significant the loss of expression is and the more likely metastasis is., Protein expression of ITGA5 decreased at labour and expression of these molecules was also observed in primary cultured human uterine SMCs., Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Integrin alpha5 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., analysis of important residues within the central turn motifs present in the cytoplasmic tails of integrin alphaIIb and alphaV subunits, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin., Both integrins, v3 and v5, are involved in the glioma cell radioresistance through the integrin-linked kinase (ILK) and the small GTPase RhoB, at least by regulating the radiation-induced mitotic cell death., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell, The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., TM4SF5 facilitates angiogenesis of neighboring endothelial cells through VEGF induction, mediated by cooperation between TM4SF5 and integrin alpha(5) of epithelial cells, findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III., This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, inhibition of the alpha5beta1 integrin reduces lymphangiogenesis in inflamed airways after M. pulmonis infection, The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., These results suggest that alpha(5)-integrin up-regulation induced by E-cadherin loss under hypoxia has a crucial role in regulating the migration of extravillous trophoblast cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., Induction of alpha5-integrin expression is a key determinant by which inhibitors of TGFbeta type-I receptor kinase and VEGF synergistically promote angiogenesis., upregulated expression in lung adenocarcinoma cells following bacterial infection, new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., These findings not only reveal that ITGA5 is required for osteoblast differentiation of adult human mesenchymal stromal cells (hMSCs) but also provide a targeted strategy using ITGA5 agonists to promote the osteogenic capacity of hMSCs., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., This study demonstrates that an important antiinflammatory aspect of glucocorticoids is regulating the expression and function of alpha5 integrin., 17beta-estradiol enhances alpha(5) integrin subunit gene expression through ERalpha-Sp1 interaction and reduces cell motility and invasion of ERalpha-positive breast cancer cells., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1, Transfection of the alpha1,2-fucosyltransferase gene into ovarian carcinoma-derived cells brought about elevated expression of integrin alpha5beta1 with Le(Y)., Integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim., EGF may influence proliferative vitreoretinopathy by promoting integrin-alpha(5) expression and subsequent proliferation and migration of retinal pigment epithelial cells., in the presence of alphavbeta3-integrin Rac1 is not required for tumor angiogenesis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction., Interaction between IGFBP2 and integrin alpha5 accelerates cell adhesion, and this, in turn, enhances JNK-mediated glioma cell migration., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Downregulation of ITGA5 is associated with multiple myeloma., Findings indicated the diverse roles of ITGA5 expression in breast cancer cells., The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., We propose that alpha(5)beta(1) integrin, which is associated with cholesterol-rich microdomains at the host cell surface, is required for NOD1 recognition of peptidoglycan and subsequent induction of NF-kappaB-dependent responses to H. pylori., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., investigation of role of ITGA5 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 calcium channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., RNA interference-mediated knockdown of CD49e (alpha5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion., Integrin 5 1 facilitates cancer cell invasion through enhanced contractile forces, In cultured intervertebral disc cells, fibronectin fragment increased the expression of MMP9,MMP13m alpha 5 and beta1 integrin via the alpha5beta1 integrin receptor., Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, The expression of the alpha5 gene in human uveal melanoma cell lines, was characterized., elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., The endoproteolytic cleavage of alphav subunits is necessary for alphavbeta5/beta6 integrin to control alpha2beta1 function and could thus play an essential role in colon cancer cell migration., Data suggest that colorectal cancer (CRC)-derived integrin alphavbeta6 is involved in the establishment of tumor immune tolerance in local tissues., growth defects in mesenchymal stromal cells in myelodysplastic syndromes were significantly correlated with decreases in CD44 adhesion molecules and CD49e., study here indicated that integrin alphaVbeta3 had lower affinity when the ADMIDAS was mutated, WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Rv2468c engaged integrin VLA-5 (alpha5beta1) on CD4+ T cells through its FN-like RGD motif GRDGSPK., alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1., ZEB2 was found to activate integrin alpha5 and vimentin promoters by interacting with and activating transcription factor Sp1, suggesting that cooperation between ZEB2 and Sp1 represents a novel mechanism of mesenchymal gene activation during epithelial-mesenchymal transition, uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, betaig-h3 co-localized with integrin alpha5beta1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule., Specific adhesion of megakaryoblasts to fibronectin via both alpha5- and alpha4-integrin molecules and phorbol 12-myristate 13-acetate (PMA) is essential for pro-platelet-like formation of megakaryocytes., Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., PKCalpha constitutes a crucial component of the integrin alphav-mediated pathway(s) that promote p53 relocalization and melanoma survival., Tauroursodeoxycholic acid induces in perfused rat liver and human HepG2 cells the rapid appearance of the active conformation of the beta subunit of alpha5beta1 integrins, followed by an activating phosphorylation of extracellular signal-regulated kinases., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., Co-expression of c-Met and Integrin alpha5beta1 has mechanical significance in the early stages of human gastric cardia adenocarcinoma., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., miR-148b controls malignancy by coordinating a novel pathway involving over 130 genes and, in particular, it directly targets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110alpha, and NRAS, as well as CSF1, High Integrin alpha5beta1 expression is associated with metastasis of colorectal cancer., Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., Calreticulin, integrin-alpha5, and TGF-beta1 expression was increased in atrial tissue in patients with AF and was related to AF type, suggesting that calreticulin is involved in the pathogenesis of AF in VHD patients., The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells., These findings support a direct role for Survivin in melanoma metastasis, which requires alpha5 integrin and suggest that inhibitors of alpha5 integrin may be useful in combating this process, Data indicate that nuclear integrin alphav monomer in T4-exposed cells, but not integrin beta3, bound to promoters of specific genes that have important roles in cancer cells., MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, the identification of ITGA5 -E2/3 splice variant as potential novel adverse prognostic marker for low-risk AML, We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, loss of BRM epigenetically induces C/EBPbeta transcription, which then directly induces alpha5 integrin transcription to promote the malignant behavior of mammary epithelial cells, 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Integrin alpha5beta1 overexpression is associated with lymph node metastasis and vascular invasion in cervical cancer., our results identify a novel regulatory pathway involving the interplay between ZO-1, alpha5-integrin and PKCepsilon in the late stages of mammalian cell division., High integrin alphaVbeta6 expression is associated with liver metastasis in colorectal cancer., Herpes simplex virus gH/gL sufficed to elicit type I IFN and NF-kappaB activation via alphavbeta3 integrin in epithelial and neuronal cell lines., these results establish that GP IIb/IIIa and alphavbeta3 integrins are essential mediators of shear flow-induced cancer cell mechanotransduction, Integrin alpha5-FAK signaling pathway controls the proliferation of bladder smooth muscle cells in response to cyclic hydrodynamic pressure., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach., Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., RhoC facilitates tumor cell invasion and promotes subsequent metastasis, in part, by enhancing integrin alpha5beta1 trafficking, We have demonstrated for the first time a new molecular pathway that connects TMPRSS4 and integrin alpha5 through miR-205 to regulate cancer cell invasion and metastasis, Overexpression of integrin alpha v is closely associated with metastasis and progression of nasopharyngeal carcinoma., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, phenotype of mice with alpha5-erythroid deletions was similar to controls, especially after stress. These outcomes seem to reconcile divergent prior views on the role of alpha5-integrin in erythropoiesis., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., In the presence of both 9-cis-retinoic acid and troglitazone, cell surface alpha5 subunit expression was restored to levels comparable to vehicle treatment alone., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., Data show that thyroid hormones induce mitogen-activated protein kinase (MAPK) via integrin alphavbeta3 in bone marrow-derived cells from multiple myeloma (MM)., demonstrate that alpha5 integrin turnover is dependent on fibronectin matrix assembly, Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., Data indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Mesodermal expression of integrin alpha5beta1 regulates neural crest development and cardiovascular morphogenesis., Data indicate that influenza A virus H1N1 infection activated alphavbeta6 integrin-dependent transforming growth factor beta (TGFbeta) activity in immortalized bronchial epithelial cells (iHBEC)., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2, Data indicate that alpha5 integrin (ITGA5) is a functional target of miroRNA miR-26a-induced anoikis in hepatocellular carcinoma (HCC) cells., Twist1 and AP-1 cooperatively upregulate integrin alpha5 expression to induce invasion and the epithelial-mesenchymal transition.Twist1 expression positively correlates with integrin alpha5 expression in human colorectal cancers., we detected higher activity of AKT (p = 0.011) and FAK (p = 0.054), higher integrin alpha5 expression (p = 0.052) and lower PTEN expression in primary cells from patients with bone metastasis compared to nonmetastasizing cells., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Integrin alphanubeta6-mediated MMP-9 secretion facilitates pericellular matrix degradation at high cell density, promoting invasive growth of colonic neoplasms., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway., Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Collagens considerably suppressed alpha5 gene expression in CECs, suggesting that during wound, Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1., Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer, The present study has revealed an integrin- and membrane lipid raft-dependent mechanotransduction mechanism by which atheroprone flow causes endothelial dysfunction., integrin alpha5 might play important roles in the progression of esophageal squamous cell carcinoma, knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased,
OFFICIAL_GENE_SYMBOL ITGA5,
SP_COMMENT function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
integrin subunit alpha V(ITGAV) integrin subunit alpha V(ITGAV) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q31-q32,
ENSEMBL_GENE_ID ENSG00000138448,
GENERIF_SUMMARY integrin alphavbeta3 is shown to interact with PECAM-1, Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin, Acute hyperglycaemia induces an up-regulation of seven major genes, four of which were not previously reported in the literature. Northern blot analyses, performed on these 4 genes, confirm macroarrays results for alphav, beta4, c-myc, and MUC18., Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI)., They analyzed the expression of these cell surface receptors in nine ovarian cancer cell lines and also in the primary human ovarian surface epithelial cell line (HOSE)., Chemotaxis and chemoinvasion analyses revealed a dose-dependent increase in prostate cancer cell movement induced by osteopontin and a strict dependence of cell invasion on alphavbeta3 integrin function., Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3), Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)., Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins., Acute cellular rejection following human heart transplantation is associated with increased expression, existence of an alpha V integrin/vitronectin connection in hepatocellular carcinoma and suggest that this connection may be an adverse prognostic factor., Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma., integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells, Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells, alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts, phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement, promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2, identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins, induced alpha(v)beta(8) integrin expression mediated Fas-stimulated migration, identification of functional segments within the beta2I-domain, Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif., role in mediating pro-angiogenic activity of CYR61, An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis., in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin, thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin., Overexpression of integrin alphaV promotes human osteosarcoma cell populated collagen lattice contraction and cell movement., activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2, Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, has a role in the early phase of liver metastasis, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, role in regulating cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells, decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures, Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies, tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner, Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development., signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis., Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, These data provide evidence for a functional role for integrin alphavbeta8-mediated activation of transforming growth factor-beta in control of human airway epithelial proliferation in vivo., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone, Disulfide bonding patterns of the integrin alpha V chain are described; the alpha chain displays differences in the disulfide patterns of those bonds near their C-terminal regions linking the heavy and light chains., alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, alphav subunit cleavage is essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47, alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., integrin alpha(v)beta(6) is an RGD-dependent receptor for Coxsackievirus A9 and may be important in natural Coxsackievirus A9 infections, alpha-v integrin signals through JAB1 (Jun activation binding protein 1) to prolong MMP1 production, secondary structure analysis of integrin alphaVbeta3, CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas, Integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling., alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix, The Integrin alphaV receptor is members of the group of the cellular adhesion molecules (CAM), are heterodimeric transmembrane glycoprotein receptors involved in processes such as cell-cell and cell-matrix adhesion, cell migration and signaling., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele, We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution., We conclude that integrin alphavbeta6-dependent MMP-2 and -9 up-regulation is an important feature of increased migration in hypoxic human keratinocytes., Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling., urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, new pair of adhesion molecules, Thy-1 and alphavbeta3, inditified that mediate the interaction of melanoma cells and activated endothelial cells, IGROV1 cells were shown to adhere rapidly on the HUVECs monolayer; adhesion was inhibited by anti-alphav integrin and anti-Vn blocking antibodies, but not by anti-beta1 integrin antibodies, Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3, May contribute to the formation of arteriovenous malformaions in younger patients., melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Alphavbeta6 integrin down-regulates MMP-13 expression in oral squamous cell carcinoma cells., Increased transcripts of activators of TGFB1 (Itgav and Thbs1), and genes that are activated by TGFB1 (Spp1, Timp1, and Tnc) occurs during acute lung injury, Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells., alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy, the RGD-dependent interaction between the P2Y(2)R and alpha(v) integrins is necessary for the P2Y(2)R to activate G(o) and to initiate G(o)-mediated signaling events leading to chemotaxis, Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption, These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., thymosin beta10, but not thymosin beta4, have direct inhibitive effects on endothelial migration and tube formation that might be mediated via downregulation of VEGF, VEGFR-1 and integrin alphaV in HCAECs., While tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and alphavbeta5 maintains the DC's tolerogenic profile., Findings suggest that in melanoma cells the increase in MMP-2 activity, CD44 surface expression, and cell migration is integrin alpha V-dependent., The effects of the EBV nuclear antigen 3C on the activities of Nm23-H1 via GATA-1 and Sp1 are reported., Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells., PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry., S 36578-2 is highly selective for alpha v beta3 and alpha v beta5 integrins and induces detachment, caspase-8 activation, and apoptosis in human umbilical endothelial cells, These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the epithelial-mesenchymal trophic unit (EMTU).[integrin alphavbt=eta6, integrin alphavbeta8], Relevance of betaIG-H3 and alpha v beta3 integrin-interacting motifs as potential therapeutic targets in rheumatoid arthritis., integrin binding loop of Foot-and-mouth disease virus has most likely evolved for binding to alphavbeta6 with a higher affinity than to alphavbeta3 and alphavbeta8, The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells., identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, Mn(2+) promoted convergent changes in integrin alphavbeta6 conformation and Fb structure through activation of ERK/MAPK and MMP-9, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Adhesion of breast cancer cells through the VLA integrins alpha2beta1 and alpha5beta1 was significantly reduced by an apoptosis-inducing natural triterpenoid, dehydrothyrsiferol (DT), when studied on low amounts of extracellular matrix., Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development., Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation, Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion., Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway., The rs3738919-C allele of the ITGAV gene is associated with rheumatoid arthritis in the European Caucasian population, suggesting ITGAV as a new minor susceptibility gene for rheumatoid arthritis., establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy, c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells, These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., Results show that the tyrosine phosphatase protein-tyrosine phosphatase mu dephosphorylated PIPKIgamma and thus canceled the PIPKIgamma-dependent activation of integrin alpha(v)beta(3) by blocking the interaction of integrin alpha(v)beta(3) with talin., the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)., Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules., anti-tumor and anti-metastatic activities of CNTO 95 in breast cancer models and provide insight into the cellular and molecular mechanisms mediating its inhibitory effects on metastasis., Signal transduction pathways underlying the enhanced cell migration reveal that the IGF-I-IGFBP-VN complex stimulates a transient activation of the ERK/MAPK signaling pathway and a sustained activation of the phosphatidylinositide 3-kinase/AKT pathway., uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, Alpha v beta 5, alpha v beta 5 and their ligands Del-1 and L1 play an important role in the process of tumor cells moving from the original place., TGF-beta1 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of chondrosarcoma cells, We used suppression subtractive hybridization (SSH) to study molecular signature of melanoma progression, by showing characteristics of early neoplastic lesions including expression of KISS1, lack of alphavbeta3-integrin and low levels of RHOC., Integrin alphavbeta6 is induced de novo in rodent and human liver fibrosis, where it is expressed on activated bile duct epithelia and (transitional) hepatocytes during fibrosis progression., The role of alpha(v)beta(3) and Fas as the mediators of streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is described., Integrin alpha v beta 3 plays a critical role in the S1P-stimulated chemotactic response of ECs, The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., T(3) and T(4) hormones rapidly stimulate ERK activation in MG-63 cells via integrin alpha(V)beta(3) and that one functional effect of this ERK activation is increased DNA synthesis, Mn(2+) simultaneously modulates the thiol isomerase activity of protein disulfide isomerase that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation, Data show that in preeclamptic pregnancies, histamine does not stimulate expression of integrin alphaVbeta3, as it does in uncomplicated pergnancies., These results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with cytomegalovirus., Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window., results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, There was significant relationship between integrin alpha-v subunit expression and lymphatic metastasis of laryngeal and hypopharyngeal squamous cell carcinoma., ROCK-dependent actomyosin-driven contractility is a critical determinant for the regulation of the interaction between Necl-5 and integrin alpha(V)beta(3)., significant difference in the expression of the beta(3) integrin subunit between primary glioblastomas compared with low-grade gliomas, expression of ITGAV was significantly correlated with differentiation and metastasis of the laryngeal and hypopharyngeal carcinomas; down-regulation of ITGAV gene could inhibit proliferation of Hep-2 cells and induce to its apoptosis., integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, Alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation., osteopontin, integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, Integrin alphavbeta3 is not significantly implicated in the anti-migratory effect of anti-angiogenic urokinase kringle domain, overexpressed in endometrial carcinomas, especially with high grade and in lymph node metastases, ability of ovarian carcinoma cells to bind to peritoneal mesothelium in vitro and strongly suggest that vitronectin and its receptors contribute to this crucial event., SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway., The apo(a) component of Lp(a) signals through integrin alphaVbeta3 to activate endothelial cells., urokinase-derived antagonists of alphavbeta5 integrin activation inhibit migration and invasion of carcinoma cells, These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion., VWF strings bind specifically to integrin alpha(v)beta(3) on human endothelial cells, Analogous to EAE, in subjects with MS, we found increased expression of Opn in DCs and increased expression of the Opn receptors CD44, beta(3), and alpha(v) on T cells., M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., in cutaneous nodular melanomas, necrosis was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin & poor patient outcome, analysis of how the different antiangiogenic potential of resveratrol stereoisomers is related to their different capacity to affect alphavbeta3 integrin function, These data suggest that Coxsackievirus A9 binding to alphaVbeta6 is a high-affinity interaction, which may indicate its importance in clinical infections, pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Data show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK, Src and VE-cadherin, increased cell permeability and decreased cell adhesion in endothelial cells., In neuroendocrine tumors, gene-expression integrin alphaV was highly variable, The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Compound 4, having the DGR retro-sequence, is a low micromolar ligand for the alphavbeta5 integrin., Data demonstrated significantly upregulated integrin-linked kinase as a function of alphavbeta3 in two ovarian cancer cell lines, and proved co-localization at the surface of alphavbeta3-overexpressing adherent cells., These data strongly indicate that KAI1 may suppress ovarian cancer progression by inhibiting integrin alphavbeta3/vitronectin-provoked tumor cell motility and proliferation as important hallmarks of the oncogenic process., Down-regulation of alphav integrin by retroviral delivery of siRNA significantly reduced drug resistance of colon tumor cells & xenografts, indicating that ITGAV plays an important role in MCR to oxaliplatin in colon cancer cells., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., In metastatic brain lesions carrying activated alpha(v)beta(3), VEGF expression is controlled at the post-transcriptional level and involves phosphorylation and inhibition of translational respressor 4E-binding protein (4E-BP1)., Tumors express alpha(v)beta(6) suggest that this probe has significant potential for the in vivo detection of the malignancy., VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of integrin alphavbeta6 expression and activation of ERK., Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3, Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, These data are the first demonstration of conformational coupling of the integrin alphaVbeta3 leg and head domains, and suggest that inside-out activation may involve conformational changes other than the postulated switch to a genu-linear state., upregulated expression in lung adenocarcinoma cells following bacterial infection, Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, Data show that leberagin-C can inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins., This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor., Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Data show that under basal conditions, sphingosine kinase-1, integrin alpha(v)beta(3), and CD31 exist as a heterotrimeric complex which is required in SK-1-mediated endothelial cell survival., Association of ITGAV SNP rs7378919 with rhuematoid arthritis was not replicated in New Zealand or Oxford case control sample sets, alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, suggest that a divalent metal-ion coordination was a common driving force for the formation of both SDV/alpha v beta 3 and RGD/alpha v beta 3 complexes., GPIIb/IIIa and alphavbeta3 integrins are important mediators in the pathology of cervical cancer., VEGFR-2 was significantly upregulated by alpha-v suppression in HUVEC & downregulated in HMVEC at mRNA & protein levels. Suppression of alpha-v can either augment or inhibit VEGFR-2 levels & VEGF-induced proliferation in EC from different vascular beds., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., The angiogenic effects of leptin are mediated by circulating angiogenic cells and involve src kinase dependent phosphorylation of integrin alphavbeta5., Blocking integrin alpha V beta 3 inhibits differentiation and subsequently tumor formation., Reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic brain arteriovenous malformations., Definitive endoderm highly express the integrins alphaV and beta5, which have the ability to bind to vitronectin., Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes., OPN and its receptor integrin alphanubeta3 may be involved in the pathogenesis of preeclampsia., Mast cell-bronchial smooth muscle cell adhesion involved collagen, CD44, and CD51, particularly under inflammatory conditions., Data show that PLT adhesion to HIMEC was ICAM-1, FKN and integrin alpha(v)beta(3) dependent., Expression of integrin alphaVbeta3 on T lymphocytes does not predict its endometrial expression., Results proved the importance of VEGF and integrin alphavbeta3 in the pathogenesis of AML., Ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation., These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions., the Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation are mechanistic consequences of endothelial Ang-2 stimulation, Alpha(V)beta(6), but not alpha(V)beta(3), blocked human parechovirus 1 cellular infectivity., Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression., A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., Integrin alphavbeta3 and Lewis Y, which is contained within it, are expressed in secretory-stage endometrial tissue., Integrin alphavbeta5 is a primary receptor for adenovirus., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., immunohistochemistry of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin as targets for contraceptive approaches or understanding of the pathogenesis of infertility offer little benefit compared with histological dating, demonstrate that alphaVbeta3 ligation results in sustained increases of PI3 kinase/Akt-dependent binding of transcription factor NF-kappaB to DNA., Periostin could be a biochemical marker of the early stromal response associated to breast cancer bone metastasis formation., PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5., Preincubation of macrophages with HMGB1 decreased their ability to engulf apoptotic neutrophils or thymocytes. Soluble alphavbeta3 integrin, but not soluble alphavbeta5 integrin, prevented this inhibition., These results demonstrate that HMGB1 blocks alpha(v)beta(3)-dependent recognition and uptake of apoptotic cells., Data showed that EhPCP5 RGD motif is a ligand for alpha(V)beta(3) integrin-mediated adhesion on colonic cells and represents a novel mechanism to trigger an inflammatory response in the pathogenesis of intestinal amebiasis., Saturation transfer difference NMR was applied to the interaction of the integrin alphavbeta6 with a known peptide ligand and highlights novel contact points between the substrate and target protein, TNF-alpha enhances the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the MEK/ERK/NF-kappaB signal transduction pathway., The mRNA levels of IntegrinalphaV and Integrinbeta8 were significantly higher in LSCC tissues than that in corresponding adjacent normal tissues., Leptin stimulates the migration of human prostate cancer cells via transcriptional up-regulation of alphavbeta3 integrin expression., Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins., TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the alphaVbeta6 integrin, an important regulator of transforming growth factor-beta1 activation., beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection., ITGAV is a genetic determinant for the severe progression of primary biliary cirrhosis in Japanese patients, When polymorphonuclear leukocytes are recruited to tumor cells in a tumor microenvironment, alphaVbeta3 and intercellular adhesion molecule (ICAM)-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circulation., Integrin alphav is the main CAM subunit of uterine leiomyomas that involve angiogenesis, The authors demonstrated that both integrins alphavbeta6 and alphavbeta8 can serve as specific receptors for Epstein-Barr virus gHgL proteins., ITGAV is present in all cortical layers, the striatum and Purkinje cells. It is known to be involved in cortical development, the role of acidic extracellular pH in regulating activation of integrin alpha(v)beta(3)., PET of alphavbeta3-integrin and alphavbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy., data demonstrated that (18)F-fluciclatide detected changes in tumor uptake after acute antiangiogenic therapy markedly earlier than any significant volumetric changes were observable., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., chemokine receptor 7 regulates cell adhesion and migration via integrin alpha v beta 3 in metastatic squamous cell carcinoma of the head and neck, S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Alpha v integrin was expressed at robust levels in tumor cells representing less differentiated, more invasive components of squamous cell carcinomas, Performed molecular dynamics to simulate forced unbending of a complete integrin alpha(v)beta ectodomain in both unliganded and liganded forms., Our findings indicate that alphavbeta5 integrin may be involved in the change that occurs in monolayer-cultured chondrocytes after plating, Direct contact between tumor cells and human epithelial-like stem cells treated with DMBA increased integrin alpha V expression and caused local activation of the transforming growth factor (TGF)-beta1/Smad signaling pathways., Integrin alphavbeta3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors, With increased tension cytoskeletal stress fibers develop that contain alphaSMA and alphavbeta3 integrin that replaces alpha2beta1 integrin, consistent with cell switching from collagen to non-collagen proteins interactions., IL-8 increases integrin alpha V expression and cell motility in human chondrosarcoma cells, Data suggest that lung fibroblast chemokine secretion directs dendritic cell trafficking, in a manner that is critically dependent on alphavbeta8-mediated activation of TGF-beta by fibroblasts., Data showt targeting of alpha(v)-integrin by GLPG0187 can inhibit both de novo formation as well as progression of bone metastases in prostate cancer., The mechanism of decreased cell migration, a prerequisite for metastasis and invasion, due to increased CAR expression may be explained by reduced alphavbeta3 integrin expression., Integrin alpha(nu) beta(3), NTRS1 and PSCA mRNA expression increased with tumorigenic potential, but mRNA expression levels for these proteins do not translate directly to equivalent expression levels of membrane bound protein., Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis., analysis of alpha(nu)beta(3) integrin expression by (64)Cu- and (68)Ga-labeled RGD conjugates, The alphav integrins are an important group of adhesion molecules involved in the migration and invasion of tumour cells., Overexpression of integrin alphav in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis, The authors report that integrin alphavbeta5 can also bind to Epstein-Barr virus gHgL and trigger fusion., alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, an important role of PTTG in regulation of integrins alpha(V) and beta(3) and adhesion-complex proteins leading to induction of EMT, Chromosomal regions of homozygous loss, encompassing the ITGAV and RUNX1 gene, were detected in multiple samples indicating a potential role in the carcinogenesis of esophageal adenocarcinoma., Integrin-alphavbeta3 was upregulated on various therapy-resistant tumor cells through chronic activation of ATM/Chk2-and NFkappaB-mediated pathways, Data show that alphav integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion., Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., MIF enhanced the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the PI3K/Akt/NF-kappaB signal transduction pathway., Disulfide bonds in EGF domains of beta3 affect structure and function of alphaIIbbeta3 and alphavbeta3 integrins in different manner., Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells., Further characterized the intermolecular interactions between alphavbeta3 integrin and hormone analogues. Data reveal T(3) and T(4)ac bind in two different modes, occupying two alternate binding sites on alphavbeta3 integrin., knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Collectively, our results indicate that FAS1 domain protein, in addition to its inhibitory effect on alpha5-beta-3 integrin-mediated angiogenesis, also inhibits VEGF165-induced angiogenesis, In vivo, we found that irradiation combined with alphaV integrin blocking treatment significantly enhanced the radiosensitivity of NPC xenografts, alpha5 endothelial cell-transgenic knockout mice display an attenuated angiogenic response which correlates with delayed endothelial proliferation; primary alpha5KO brain endothelial cells in culture exhibit delayed growth and proliferation., our findings indicate that alphavbeta6 and TGF-beta act in a common tumor suppressor pathway, Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through alphav-integrin membrane translocation, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., CD44 signaling regulates phosphorylation of RUNX2. Localization of RUNX2 in the nucleus requires phosphorylation of Smad-5 by integrin alphavbeta3 signaling., The Protein kinase D (PKD) mediates signals from the platelet-derived growth factor receptor (PDGF-R) to control alphavbeta3 integrin recycling., thioridazine regulates endothelial cell functions that are relevant to angiogenesis through the suppression of the alphavbeta3/FAK/mTOR signaling pathway, Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity., The results demonstrate a non-redundant role for alpha(v)beta(3) in gremlin-induced angiogenesis., observations suggest that the lack of simultaneous binding of metal ions to all three betaI domain sites in alphaVbeta3 is most simply explained as an artifact of crystallization conditions, Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer., Consistent with prediction, docking simulation studies of fractalkine's chemokine domain show direct interaction with integrins alphavbeta3 and alpha4beta1 at very high affinity., overexpression of the ITGAV gene and protein was correlated with an increased risk of perineural invasion in colorectal cancer., propose that alphavbeta3-integrin is considered a class of non-TLR pattern recognition receptors., alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration, RGD peptide plays an important role in the modulation of cell motility and in the perturbation of cell attachment affecting the malignant potential of breast cancer cells via binding to integrin alphavbeta3., CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength, CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways., Integrins alphavbeta3 and alphavbeta5 and their ligands are expressed in distinct and heterogeneous patterns in primary and secondary central nervous system neoplasms., integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma, study demonstrate that binding of integrin alphavbeta5 and alpha defensin 5 have opposite effects on the elastic response of adenovirus type 35, revealing a direct link between virus-host interactions and the mechanical properties of the capsid, alphavbeta8 integrin, via interactions with RhoGDI1, regulates activation of Rho proteins to promote glioblastoma multiforme cell invasiveness., Increased alphavbeta6 integrin expression is associated with poor prognosis and decreased survival in oral squamous cell carcinoma patients., Data indicate that EGFL7 and integrin alphavbeta3 integrin colocalized in vesicular structures in uman umbilical vein endothelial cells (HUVECs)., Our data indicate that expression of [alpha]v[beta]3 in tumor cells and vessels is dependent on tumor grade, and that its expression in tumor cells may have a prognostic impact., the integrin avb6 plays an important role in the fusion of endosome/lysosome in corneal epithelial cells; inhibition of avb6 results in corneal epithelial barrier dysfunction., Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells., Results show that stromal cell-derived factor-1 (SDF-1) enhanced ovarian cancer cell invasion through alphavbeta6 integrin-mediated urokinase-type plasminogen activator (uPA) expression via the p38 MAPK and PI3 K/Akt pathway., Data indicate CCN1 can induce actin reorganization, formation of lamellipodia, and cell migration/invasion through the alphaV integrins/Rac1/ERK signaling axis; these CCN1-dependent activities can be effectively suppressed by monoclonal antibody YM1B., The coupling of extracellular matrices to integrin alphaV is necessary for Glioma initiating cell differentiation., Interaction of vitronectin with integrin alphavbeta3 results in the continued activation of the kinase mTOR., the expression of Lewis y antigen, integrin alphav and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction., PDGFRalpha CD51 cells in fetal bone marrow represent a small subset of CD146 cells expressing Nestin and enriched for mesenchymal stem cell and hematopoietic stem cell niche activities., The alphavbeta5 integrin-FAK-mediated pathway regulates phagocytosis in trabecular meshwork cells and this pathway is inhibited by activation of alphavbeta3 integrins., A switchblade-like movement of the integrin leg is indispensable for the affinity regulation of alphaVbeta3 integrin., We report a protein expression profile in high-grade osteosarcoma associating beta5 integrin, FAK, and GSK3beta that significantly correlates with poor response to neoadjuvant chemotherapy., Interaction between CCL2 and CCR2 enhances migration of prostate cancer cells through an increase in alphavbeta3 integrin production, Real-time imaging of alphav integrin molecular dynamics in human 143B osteosarcoma cells in vitro and in vivo, is reported., The level of OPN expression in lung adenocarcinoma was associated with decreased apoptotic activity of tumor cells, and correlated with alphav integrin expression, particularly in low stage tumors., GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent, upregulation of alphavbeta6 on myoepithelial cells generates a tumor promoter function through TGFbeta upregulation of MMP-9. These data suggest that expression of alphavbeta6 may be used to stratify patients with DCIS., Brain metastases ITGAV expression exhibits considerable heterogeneity according to tumor origin., Complement C3, vitronectin, and apolipoprotein A-I were further confirmed by western blotting, and the results showed that their contents decreased significantly after transient limb ischemia., alphavbeta6- and alphavbeta8-integrins acted independently and are thus interchangeable as receptors for Herpes simplex type 1 virus entry., Results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of rheumatoid arthritis., findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells, [(18)F]Galacto-RGD PET/CT shows specific tracer accumulation in human atherosclerotic carotid plaques, which correlates with alphavbeta3 expression., Inhibition of integrin alphavbeta3 results in significant inhibition of trophoblast attachment., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., High integrin alphaVbeta3 expression is associated with hepatocellular carcinoma., cilengitide can significantly down-regulate ITGAV expression and inhibit cell proliferation in laryngeal cancer cells, it will also to induce cell apoptosis through caspase-3 pathway., Expression of Gli1 and alphavbeta6 inversely correlates in tumours in vivo, and Hh targeting up-regulates TGF-beta1/Smad2/3-dependent alphavbeta6 expression, promoting pro-tumourigenic cell functions in vitro., Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, The use of LIF in combination with alphanubeta3 integrin as biomarkers appears to be superior to integrin testing alone when evaluating endometrial receptivity, primarily because of its earlier pattern of expression during the secretory phase., Overexpression of integrin alphav is associated with advanced T and N stage and as an independent prognostic factor in colorectal carcinoma., In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav., This co-targeting strategy relies on the interaction of MMP-2 with integrin a(v)b(3), which are known to associate via the hemopexin domain of MMP-2, These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3., The increased surface expression of alpha5beta1 integrin, along with the adhesion between the cells and fibronectin, could be inhibited by both ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) kinase inhibitors, Data show that chemokine domain of fractalkine (FKN-CD) can activate alphavbeta3 integrin in the absence of fractalkine receptor CX3CR1, but that this activation requires the direct binding of FKN-CD to alphavbeta3., Studies sugggest that the effect of integrin alphavbeta3 in the whole process of brain function recovery merits further study., Coimmunoprecipitation studies and proximity ligation assays indicated that integrin alphavbeta3 interacts with herpes simplex virus type 2 glycoprotein H (gH)., Herpesvirus 8 attachment and entry are dependent on alphaVbeta3 integrin localized to specific cell surface microdomains., alphavbeta3 was necessary and sufficient for Slug activation, the present study demonstrated that the link between systemic inflammatory markers and the ITGAV-rs3911238 polymorphism allele in Iranian RA patients., Expression of alphav integrin subunits seem to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases., The levels of integrin alpha(nu)beta(3) between normal skin and hypertrophic scar tissues were compared, and integrin alpha(nu)beta(3) was found to be upregulated in hypertrophic scar., overexpression of integrin alphav induces integrin alphavb8 heterodimer formation and the binding of integrin alphavbeta8 to type collagen might enhance the proliferation and invasion of SCC cells via the activation of the MEK/ERK signaling pathway., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., Inhibition of tumor-associated alphavbeta3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo., Low NAMPT is associated with upregulation of alphavbeta3 integrin in breast tumor cells., The importance of interaction between EDIL3 and integrin alphaV., The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion., Exogenous ATX controls breast cancer cell proliferation, invasion, and endothelial cell transmigration via interaction tumor integrin alphaVbeta3., post-treatment of peptides derived from the full-length tail or from the turn motif did not reverse aIIb and aV integrin activation., Unique sites of interaction between alphavbeta6 and uPAR are most likely located in uPAR domains II and III., The identification of integrin alphavbeta6 in a subset of DCIS presents a unique way to stratify patients with DCIS into those who may or may not progress to more serious disease., Integrin alphav promotes the proliferation of the human lung cancer cell line A549 by activating the ERK 1/2 signaling pathway, Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrin alphaVbeta3, integrin alphavbeta1, and integrin alpha4beta1., Integrin alphaVbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells., suggest that the OPN-integrin alphavbeta3 axis is crucial for 5-FU resistance in oral scandalous cell carcinoma, Integrin alphavbeta3 is required for cathepsin B-induced hepatocellular carcinoma progression, Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., high levels of alphavbeta6 integrin may identify a specific endotype of progressive fibrotic lung disease, Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., alphav integrin is required for efficient TGF-beta/Smad signaling and TGF-beta-induced breast cancer cell migration, and for maintaining a mesenchymal phenotype of the breast cancer cells., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with av- and a6-integrin expression, Our results show that the acquisition of metastatic competence by melanoma cells is accompanied by alteration of alphavbeta3 integrin glycosylation and that both avb3 and b1-6-branched sialylated complex-type N-glycans promote metastatic melanoma migration, These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK/Pyk2 signaling pathways., targeting eIF4E in integrin avb6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer., Herpes simplex virus entry is enabled by gH/gL interaction with alphavbeta6- or alphavbeta8-integrin receptors., ERK-mediated transcription regulation of the alphav monomer is regulated by T3. Thyroid hormones are potent alphavbeta3-ligands, driving ovarian cancer cell proliferation., The combined impacts of alphav-integrin and HER2 influence the invasive phenotype of breast cancer cells., These findings suggest that enhanced integrin alphavbeta3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-beta1-induced EMT in mammary epithelial cells., Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.,
OFFICIAL_GENE_SYMBOL ITGAV,
SP_COMMENT function:The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.,
integrin subunit beta 1(ITGB1) integrin subunit beta 1(ITGB1) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10p11.2,
ENSEMBL_GENE_ID ENSG00000150093,
GENERIF_SUMMARY the linkage between beta1 integrin and actin may be differentially regulated by its tyrosine and serine/threonine phosphorylation in normal and cancerous breast cells., Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling, Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction, both VEGF-induced PI 3-kinase activation and beta(1) integrin-mediated binding to fibronectin are required for the recruitment and activation of PKC alpha., Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines., Although cytoplasmic splice variants do not change the ligand-specificity of a beta 1 integrin, this review explains how clustering of different splice variants triggers signaling pathways that lead to a different cellular response., beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican, These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells., Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, Data demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins such as CD151 are palmitoylated, and that palmitoylation is not required for cd151-alpha3beta1 integrin association., Activated Notch4 inhibits angiogenesis, role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding, mechanical stress to the beta1-integrin subunit in osteoblasts revealed that cyclic forces of 1 Hz were more effective to stimulate the cellular calcium response than continuous load, beta1 and beta2 integrins activate different signalling pathways in monocytes., Inv-induced cell death was mediated via beta1-integrins since Inv bound to the beta1-integrin subunit (CD29), anti-beta(1)-integrin antibodies blocked Inv-induced cell death and Inv-induced cell death was absent in two beta1-integrin- cell lines., Beta1 integrin triggering affects leukemic cell line sensitivity to natural killer cells, Evidence for distinctive signaling of CD82- and beta1 integrin-mediated costimulation at the transcriptional level of IL-2 gene., There is a desensitization of IL-8-mediated p42/p44 MAPK signaling in response to ligation of the alpha5beta1 integrin in PMNL. There may be an interplay between integrin and chemokine signaling during PMNL migration through the extracellular matrix., Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines, Ionizing radiation strongly induced the expression of functional beta1-integrin and ILK in the two lung cancer cell lines, A549 and SKMES1., mediates adhesion of osteosarcoma to the core region of thrombospondin 1 (alpha 4 beta 1 integrin), role in regulating beta 1 integrin-dependent leukocyte adhesion, results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, VLA4 integrin activation by chemokines requires cholesterol, role of Rap1 GTPase for Mn(2+)- and antibody-induced VLA-4-mediated cell adhesion [VLA-4], Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., Data show that, in vitro, under physiological conditions, CD98 is constitutively associated with beta1 integrins regardless of activation status., Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, data suggest that overexpression of beta 1-integrin confers resistance to apoptosis in hepatoma cells via a MAP kinase dependent pathway, regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47, role in mediating pro-angiogenic activity of CYR61, beta1 integrin engagement is required for bombesin-dependent pro-MMP-9 activation in prostatic cancer cells, initial adhesion of endometrial cells to mesothelium is not mediated by beta1 integrins but attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins, molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes, findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought, Temporal gene expression profile of precursor B leukemia cells induced by ITGB1 identifies pathways regulating B-cell survival., results are consistent with an essential role for beta(1) integrins in maintenance of cardiomyocyte viability and interaction with extracellular matrix, Data show that the expression of the PAINS-13 epitope depends on CD9 association with alpha(6)beta(1) integrin., Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., beta1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by its gC1q domain, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1, integrin beta1 cytoplasmic peptides self-associate; role in beta1 integrin clustering and formation of focal adhesions, beta(1) integrin has a role in the syndecan-4 pathway for cell spreading, along with PKCalpha and RhoA, Overexpression of AKT2/protein kinase Bbeta leads to up-regulation, increased invasion, and metastasis of human breast and ovarian cancer cells., that the expression of beta(1C) integrin, a very efficient inhibitor of cell proliferation, may be modulated by the maternal microenvironment and may play a fundamental role in mediating trophoblast outgrowth and migration during pregnancy., Results establish, for the first time, mutation as a mechanism by which integrins can contribute to neoplasia., Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, beta1 integrin has a role in selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, determination of crystal structure in complex with an antibody Fab fragment, Data show that NADPH oxidase activation production of reactive oxygen species are involved in the increase of alpha2beta1-integrin plasma membrane expression in Caco-2 cells stimulated with type IV collagen., endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., expression of beta1 integrin subunit is responsible for differentiation-associated changes in cells behavior in terminally differentiated oral keratinocytes, capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation., adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated in platelets, identification of binding site in gamma C-domain of fibrinogen, Decidual beta1 integrin and FAK participate in this final step of implantation., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alpha 6 beta 1 binds to CCN1, Alpha4beta1 integrin has a role in cell adhesion, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, cells overexpressing beta 1-integrin exhibited increased proliferation in response to hepatocyte growth factor., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., identify intracellular signals involved in integrin BETA1-initiated internalization of S. aureus, in beta-thalassemic patients, significant reduction of CD49d, CD29 and CD71 antigen expression was found in peripheral blood nucleated red cells, upon treatment with phorbol esters, K562 cells become adherent and permissive for parvovirus B19 entry, which is mediated by alpha 5 beta 1 integrins, but only in their high-affinity conformation, alpha6beta1 integrins have roles as thrombospondin receptors in microvascular and large vessel endothelial cells, Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit., S-phase delay induced by overexpression of integrin beta1 subunit caused by decrease of protein kinase B phosphorylation and subsequent increases of p21(cip1) and p27(kip1) proteins. May be involved in unoccupied alpha5beta1 because of lack of ligands., Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin., In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels., The beta1-integrin-ligand disengagement resulted in capillary disruption and stimulated p38 MAPK and extracellular signal-regulated kinase activity., beta1 integrin/FAK-mediated signaling on osteoblasts could be involved in ICAM-1- and RANKL-dependent osteoclast maturation, results suggest that beta1 integrin is a common receptor for AfaD invasins and that additional AfaD-type-specific receptors exist, The structural conformation of this protein, complexed wigh integrin alpha5, complexed with fibronectin, is examined, Reduced beta1 integrin-mediated cell adhesion of HME cells to the substratum during mitosis may be induced by beta1 integrin phosphorylation at threonines 788-789 and its reduced ability to link with the actin cytoskeleton., role in ganglioside GM3 blocking of epidermal growth factor receptor, following priming of human neutrophils with lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha), addition of formyl-Met-Leu-Phe (fMLP) results in a "stimulated", sepsis-like, four- to fivefold rise in CD49d expression, the failure of beta1 integrin dephosphorylation at threonines 788 and 789 may be due to a significant reduction in the PP2A-A expression in tumor cells, integrin beta1 interacts with galectin 1, Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin., human platelet deposition on collagen depends on the concerted interplay of several receptors, Data demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of putative pancreatic progenitors on Netrin-1., ligand-binding specificities of integrin alpha3beta1 and alpha6beta1, Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., alpha3beta1 integrin binding to laminin-5 depends on its proteolytic processing, beta1C integrin splice variant is transcriptionally regulated in human prostate adenocarcinoma, integrin alpha4beta1 is induced by p53 and has a role in B-cell chronic lymphocytic leukemia drug resistance, Key role of the regulation of beta 1C integrin expression in the pathogenesis of endometrial proliferative diseases, results suggest that a direct interaction occurs between the Adenovirus penton base protein and the integrin receptor alpha3beta1 in vitro and in vivo, results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes, alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, Data show that stimulation-dependent recycling of integrin beta1 is regulated by ARF6 and Rab11, and also requires the actin cytoskeleton in an ARF6-dependent manner., results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling, Alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis., beta1 integrin maturation and transport to the cell surface is regulated by low density lipoprotein receptor-related protein-1, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta I-like and alpha I domain activation involves structurally analogous alpha7-helix axial displacements., beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis., EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions, findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells, Overexpression of integrin beta(1)modifies the response of I(Ca)to beta-adrenergic receptor stimulation., conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation, very late antigen-4 affinity is modulated by shear, alpha2beta1 integrin has a role in endorepellin-induced endothelial cell disassembly of actin cytoskeleton and focal adhesions, role in chemotaxis in conjuction with plasmin, Increases in IGF-IR decrease beta1 integrin expression, and enhance cell migration in neuroblastoma cells., alpha2beta1 integrin and GPVI regulate stress fiber formation in megakarocytes, the primary actin structures needed for cell contraction, Calu-1 lung cancer cells use primarily a beta1-integrin-mediated intracellular tyrosine phosphorylation phenomenon as the key regulatory mechanism for its binding advantage to Coll IV matrix., alpha 3 beta 1 integrin is necessary and sufficient for maximal keratinocyte survival on laminin-5, alpha4beta1 integrin on sickle reticulocytes is a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides., cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin, ILK regulates alpha 2 beta 1 in HEL cells, is activated in platelets and associates with beta 1-integrins, integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., 16K expression inhibits beta(1) integrin surface expression and spreading on matrix by a novel mechanism that results in reduced levels of functional beta(1) integrin, alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis, The integrin, beta 1 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes, Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., Activation of PI3K following beta1-integrin engagement on human CD34+ cells results in subsequent phosphorylation of PYK2, and is required for the recruitment of the PI3K/PYK2 complex to beta1-integrins at the cell surface., Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of hepatocellular carcinoma cells to laminin., demonstrates a cooperative role between alpha5beta1 and alpha4beta1 integrins and suggests that interactions between the Hep II domain and alpha4beta1 integrin could modulate the strength of cytoskeleton-mediated processes in the trabecular meshwork, ICAM-1 molecules interacted only with group B Streptococcus(GBS)-III liquor 90356 strain while beta1 integrin interacted with GBS-III liquor 90356 and GBS-V blood 90186 invasive strains, VEGF-C and VEGF-D are ligands for the integrin alpha9beta1, The expressive fluorescent intensity of integrinbeta(1) in G(1) phase SMMC-7721 cells was depressed more significantly than the values of S phase., analysis of transcriptional regulation of beta1 integrin expression in endometrium and endometrial neoplasms, Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Results indicate that CD151 association modulates the ligand-binding activity of integrin alpha3beta1 through stabilizing its activated conformation not only with purified proteins but also in a physiological context., JAM1 regulates epithelial cell morphology and beta1 integrin expression by modulating activity of the small GTPase Rap1., Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., integrin beta1 function is modulated by CD98 in polarized epithelial cells, VEGF and alpha4beta1 integrin have roles in chemokine-induced motility on and through endothelium in chronic lymphocytic leukemia cells but not in normal B lymphocytes, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, Interacts with vimentin, but this association is lost after prolonged adhesion of endothelial cells to collagen., Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation., Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway, activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion, KSHV gB can activate VEGFR-3 on the microvascular endothelium and modulate endothelial cell migration and proliferation via an interaction between the alpha3beta1 integrin and the VEGFR-3 receptor, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, matrix-derived mechanical forces sensed by beta1 integrin are capable of modulating ILK activity which regulates fibroblast viability via an Akt-dependent mechanism, alpha3beta1 integrin binding results in a suppression of the interleukin-1 signaling pathway leading to the activation of NF-(kappa)B, alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density, FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, analysis of platelet glycoprotein I(b)alpha and integrin alpha2beta1 polymorphisms in diverse populations, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, Expression pattern of integrin subunits in the human fetal pancreas (8-20 weeks fetal age) and the relevance of beta1 integrin function for insulin gene expression and islet cell survival., PDGFR-dependent cell detachment is induced by S1P via inhibition of beta1 integrin in HEK293 cells, Three intracytoplasmic motifs of the tail of VLA-4 beta 1 subunit differentially regulate VLA-4-mediated adhesive functions under static adhesion and shear flow conditions., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1, the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, phenotypic conversion and reversion of bladder cancer cells is controlled by a glycosynapse 3 microdomain through GM3-mediated interaction of alpha3beta1 integrin with CD9, Results provide evidence for a novel species of beta1 integrin on the cell surface, which does not appear to be associated with any alpha chain., alpha2beta1 and signaling via autocrine mediators facilitate and amplify the GPVI procoagulant activity of fibrillar and non-fibrillar collagens, IFN-gamma attenuates epithelial wound closure by microtubule-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of focal adhesion complexes and cell migration., mapping of the N-glycosylation sites on the beta1 integrin to better understand the potential effects of differential sialylation on integrin structure/function, The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells., Cells deficient in beta1 integrin can bind human ADAM12 via beta3 integrin., the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia, suggests beta1-integrins as critical regulators of cell survival after radiation-induced genotoxic injury, beta 1 integrin has roles in cell adhesion and migration in development and metastasis [review], beta1 integrin is critical for the alveolar morphogenesis of a glandular epithelium and for maintenance of its differentiated function, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, isolated beta1 cytoplasmic domain expression induces caspase-independent detachment of viable endothelial cells and that death is secondary to detachment (i.e. anoikis), Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain, Our data show that alpha3beta1 integrin function may be altered by glycosylation, that both subunits contribute to these changes, and glycosylation may be considered a newly found mechanism in the regulation of integrin function., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., Platelets, by binding via P-selectin to PSGL-1 on monocytes, induce up-regulation and activation of beta1 and beta2integrins and increased adhesion of monocytes to activated endothelium., The Integrin beta1 thrombogenic polymorphism and FcgammaRIIA expression could play a role in platelet sensitivity to collagen in type 2 diabetes., The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., decreased podocyte expression of alpha3beta1 integrins is closely related with podocyte depletion, glomerular sclerosis, and daily protein loss in patients with primary focal glomerulosclerosis, facilitates reovirus internalization and suggest that viral entry occurs by interactions of reovirus virions with independent attachment and entry receptors on the cell surface., IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., This study supports matrix-induced clustering of alpha3beta1 integrin promotes uPAR/alpha3beta1 interaction; potentiating cellular signal transduction pathways culminating in activation of uPA expression and enhanced uPA-dependent invasive behavior., EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization, urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, Beta1-integrin subunit is identified as a new gastrin-regulated gene in human pancreatic cancer cells., Data indicate that integrin beta1 plays a major and complex role in osteoblastic differentiation modulated by either surface microarchitecture or 1alpha,25(OH)2D3., RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR., Slug regulates integrin alpha3, beta1, and beta4 expression and cell proliferation in human epidermal keratinocytes, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, Data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells., These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells., Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer., The formation of dendrites is shown to require the interaction between the beta1-integrin (CD29) on the surface of the DCs and fibronectin in the extracellular matrix., Data show that the integrin beta1 repertoire in renal cell carcinoma is different from normal proximal tubule cells, and that valproic acid acts on all investigated integrin subtypes to restore the receptor pattern typical for non-malignant cells., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, This is the first demonstration that the integrin beta1 tail can regulate centrosome function, the assembly of the mitotic spindle, and cytokinesis., Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies., Salivary progenitor epithelial cell survival is beta 1 integrin-dependent., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, Results show that alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells., results indicate that exported alpha-toxin inhibits the adhesion and internalization of S. aureus by interfering with integrin-mediated pathogen-host cell interactions., integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, comparison of DOCK2 and Vav1 involvement in CXCL12-promoted Rac activation and alpha4beta1-dependent human T cell adhesion indicated a more prominent role of Vav1 than DOCK2, IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry, Primary human mesenchymal stem cells are able to induce self-renewing divisions of hematopoietic progenitor cellsby a beta(1)-integrin-dependent mechanism., Results show that coculture with ECs enhances VSMC adhesion and spreading by up-regulating beta(1)-integrin expression and activating the PI3K/Akt pathway. Interaction between ECs and VSMCs serves a role in vascular homeostasis and remodeling., decrease of beta(1)D-integrin & FAK in ischemic cardiomyopathy; loss of beta(1)Dintegrin-FAK-complex in ICM paralleled by reduced AKT activity supporting in vitro data showing role of intact integrin function in anti-apoptotic signaling & cell survival, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, IL4-induced FBGC are characterized by the expression of alphaMbeta2, alphaXbeta2, alpha5beta1, alphaVbeta1, alpha2beta1, and alpha3beta1, which indicates potential interactions with fragments of C3, fibrin(ogen), fibronectin, Factor X, and vitronectin, alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells, Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner., The integrin activation level, assessed by binding of soluble collagen to the alpha2beta1 integrin, was reduced upon cell treatment with DT. The TS2/16, an anti-beta1 activating monoclonal antibody was able to rescue DT-treated cells from apoptosis., High affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells., These experiments identify a new compound that can interfere with biological processes by inhibiting microdomain formation and also identify beta1 integrin as a potential mediator of signaling by GSLs., Lubrol-RAFTs probably represent the platform for tumor-promoting ephrin-B2-integrin-beta1 interaction, which could become an interesting target for future antitumoral therapies, integrin beta1 has a role in inhibiting cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway, both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, These results suggest that engagement of beta1 integrins on systemic lupus erythematosus T cells could induce FAK-mediated signaling and subsequent CD40L expression and proliferation., These results indicate that binding of the alpha3beta1 integrin results in a suppression in the activation of the IL-1 induced intracellular signaling pathway from JNK to AP-1., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest an important role of integrin alpha2beta1, alpha3beta1, and alpha5beta1 in the architectural characteristics of ameloblastomas and adenomatoid odentogenic tumor, In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression., Data show that in bullous pemphigoid, expression of beta1 was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., This study identifies alpha2 beta1 integrin as an important regulatory pathway of IFN-gamma expression and provides novel insights into the signaling mechanisms of integrin costimulation in T cells., The VCAM-1/very late activation antigen 4 adhesive system critically mediates endothelial progenitor cell adhesion to cultured rheumatoid arthritis fibroblasts and to rheumatoid arthritis synovial tissue, LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, support a model in which KAI1/CD82 attenuates the maturation of the beta1 integrin precursor and thereby suppresses cell migration, T-cadherin may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in squamous cell carcinoma by regulating surface level of beta1 integrin, talin 1 is a versatile VLA-4 affinity regulator implicated in both spontaneous and chemokine-triggered rapid adhesions to VCAM-1., results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment, No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy., Beta1 and alpha3 integrins are functionally important receptors for type 1 pili-expressing bacteria within the urinary tract and possibly at other sites within the host., CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells, Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation., CXCR4 contributes to renal carcinoma cells (RCC) dissemination and may provide a novel link between CXCL12 expression and integrin beta1 triggered RCC adhesion to the vascular wall and subendothelial matrix components, Np-1 confers a growth and survival advantage to pancreas cancer cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness., The process of dynamic integrin regulation may be an important part in tumour cell migration strategy, switching the cells from being adhesive to becoming motile and invasive., identification of alpha3beta1 as the predominant integrin and laminin receptor in glioma cells, and as a brain invasion-mediating integrin, IGF-I receptor and beta1-integrin signaling may play an important role in protective effect of hyaluronic acid on interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, TGF-beta2 promoted human lens epithelial cell adhesion and migration in vitro. Integrin beta1 and integrin-mediated signaling are necessary for TGF-beta2-promoted adhesion and migration in human lens epithelial cells., The expression of beta1-integrin was found to be significantly reduced in photoaged skin and ratios of the expressions of involucrin to beta1-integrin were increased 2.6-fold only in elderly subjects., These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal., These results strongly suggest that enhanced expression of alpha3beta1 integrin on hepatocellular carcinoma cells is directly involved in their malignant phenotypes such as invasion and metastasis., The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an extracellular matrix-dependent and integrin-mediated manner., These data demonstrate that activation of Epac1 increases integrin activity and integrin-dependent homing functions of progenitor cells., tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation., results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion, Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells., Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins., The physiologically relevant organ culture assay employed here is a potential research tool for exploring whether targeted stimulation of beta1 integrin-mediated signalling is a suitable candidate for human hair loss management., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin., Integrin beta1 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., Integrin beta 1 transgene is involved in the phagocytosis of certain bacteria, including group B streptococcus and Staphylococcus aureus, and critically regulates phagosome maturation through Rac expression., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., Beta1 integrin/Fak/Src signaling translates into integrated mediating functions of p38b activation and regulation of Bcl-2 homologs by PI3-K/Akt-1 and MEK/Erk, consequently determining their requirement (or not) for survival., B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44., H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin-JNK pathway, HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, Hypersialylated beta1 integrin is endogenously expressed in human astrocytoma cell lines., Show a critical role of PKCdelta in the regulation of renal carcinoma cell migration, which seems to be caused by affecting the expression and activity of beta1 integrins and focal adhesion kinase., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes, key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., The data suggest that phosphoenolpyruvate -dependent decrease of collagen biosynthesis in cultured human skin fibroblasts may undergo through depression of alpha(2)beta(1) integrin and IGF-IR signaling., CD151 regulates integrin alpha3beta1 functions in two independent aspects, TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation[review], Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients, study reports that T cell costimulation by the integrin VLA-4 (alpha4beta1) required SLP-76 domains implicated in microcluster assembly, Integrin alpha2beta1 may promote migration and invasion of neuroblastoma cells., Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., These results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of enterotoxin function and rotavirus pathogenesis, further distinguishing this viral virulence factor from other microbial enterotoxins., The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., LPS or peritoneal dialysis effluent stimulated the adherence of T cells to mesothelial cells, a process mediated by the integrins alpha6beta1 and alpha4beta1, Chemotherapy-induced overexpression of integrin b1 in some multiple myeloma patients upregulates LRP expression in bone marrow cells, inducing antineoplastic drug resistance., Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis ., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, gal-3 binds directly and preferentially to unsialylated, as compared with alpha2-6-sialylated, beta1 integrins, EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Results suggest that HAb18G/CD147 enhances the invasion and metastatic potentials of human hepatoma cells via integrin alpha3beta1-mediated FAK-paxillin and FAKPI3K-Ca(2+) signal pathways., Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., The mRNA levels of integrin beta1 and ILK protein were significantly higher in laryngeal carcinoma than in the surrounding tissue and vocal cord polyps., These data data suggest that, in migrating intestinal epithelial cells, beta(1)-integrin is internalized via a dynamin-dependent lipid raft-mediated pathway., Preferential downregulation of beta1-integrin expression on progenitor cells can reduce the tethering forces to BM components, thus facilitating their egress to the peripheral circulation during an allergic inflammatory response., SEMA3A suppression of tumor cell migration is dependent on alpha2beta1, the expression of which is stimulated in breast tumor cells by an autocrine SEMA3A pathway., tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges., analysis of distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens., These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The integrin beta1-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas., VLA-4, a heterodimer of CD49d and CD29, is the most important adhesion molecule for cell-adhesion-mediated drug resistance in multiple myeloma cells., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins, Our results argue for the involvement of galectin-1 in the PKCepsilon/vimentin-controlled trafficking of integrin-beta1, Overexpression of GluR1 positively correlated with glioma cell adhesion to type I and type IV collagen which was decreased in cells with blocking antibodies to beta1 integrin, NO targets activation-dependent adhesion mediated by alpha(2)beta(1), possibly by reducing bioavailability of platelet-derived ADP, but has no effect on activation-independent adhesion mediated by GPVI, analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1, The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789., overexpression of ITGB1 may be related to resistance to chemotherapy in esophageal squamous cell carcinoma, These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth., Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a "vicious cycle" between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction., Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state., Suggest that the specific interaction of MCT4 with beta(1)-integrin may regulate cell migration through modulation of focal adhesions., mechanisms by which TF induces estrogen receptor alpha expression in breast cancer involve both PAR2 and beta(1)-integrin, Integrin-beta1 was overexpressed in oral leukoplakia, and may correlate to the proliferation of the dysplasia cells., TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., Functional live-cell imaging demonstrates that ITGB1 promotes type IV collagen degradation by breast and prostate cancer cells., alpha 3, alpha 6A, and beta 1 integrin expression in cancer cells at the invasive front are related to the mode of invasion and prognosis in oral squamous cell carcinoma, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Results suggest that prostaglandin E2 mainly induces the activation of beta(1)-integrins via the EP(2) receptor in human coronary arterial endothelial cells., Stress application to activated beta1 integrins increases Galphas recruitment and activates these large G proteins within focal adhesions, JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration., findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, Expression of a genetic variant in the I-like domain of beta1 integrins does not affect normal epidermal homeostasis, but increases skin tumor susceptibility and influences tumor type in transgenice mice., High levels of VLA-4 is associated with mantle cell lymphoma., Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects, These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function, This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp., Cdc42 activity is impaired in beta1 integrin-deficient T cells that form conjugates with antigen-presenting cells but is partially restored in the context of an antigen-specific synapse., Data showed that tumor-associated matrices induced PI3K and beta1-integrin dependent Akt/PKB activity in MDA-MB-231 cells., These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence., Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN., Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin., TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling., alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization, Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, Compared with open surgery, laparoscopy-assisted radical gastrectomy is not associated with a greater effect on the expression of ICAM-1 and integrin beta(1) in peritoneal mesothelial cells., These findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, These findings support a role for FLNa-beta1 integrin as a mechanosensitive complex that bidirectionally senses the tension of the matrix and, in turn, regulates cellular contractility and response to this matrix tension., decreased expression on allograft T cells of healthy bone marrow donors following Granulocyte colony-stimulating factor pretransplant conditioning, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, The presence of the alpha11 integrin chain during early corneal development and the enhanced expression in scarred keratoconus corneas indicates that integrin chain is likely to play an important role in collagen deposition during corneal development, In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., these results highlight for the first time the considerable role of the integrin alpha6beta1 in glioma progression., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche, Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., A GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation., is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1], Interactions between type I collagen and beta1 integrins augment apoB secretion by Caco-2 cells., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes, a central role for alpha2beta1 integrin in experimental and developmental angiogenesis, upregulated expression in lung adenocarcinoma cells following bacterial infection, Musashi-1 and beta1-integrin may be involved in human colorectal tumor carcinogenesis and progression., ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway., AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression., Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations., new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., Among laminin-binding integrins, mast cells express alpha3beta1 (but not alpha6beta1, alpha7beta1, or alpha6beta4) integrins., Gal-3 promotes epithelial cell migration by cross-linking MGAT5-modified complex N-glycans on alpha3beta1 integrin., Integrins alpha3beta1 and alpha6beta1 are important cell surface receptors that mediate the chemotaxis of hepatocelluar carcinoma cells toward laminin., Integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 to mediate tumor invasion and metastatic processes., Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP, ERbeta affects integrin expression and clustering and consequently modulates adhesion and migration of breast cancer cells., although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Detecting intracellular Erk1/2 phosphorylation and IL-2 and IFN-g production, study confirmed that multiple signals, including VLA-4 engagement, are necessary for maximal T-cell activation beyond that induced via the TCR and CD28., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads., Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., beta(1)-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients, Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., in its entry strategy human echovirus 1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor, results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Targeting of integrin beta1 and kinesin 2alpha by microRNA 183., Induced integrin alpha5 and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest., Collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and this effect is mediated by the interaction of collagen with integrin alpha2beta1., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., These results suggest that both gangliosides and beta1-integrin are required for maintenance of caveolae and plasma membrane domains., conserved NPXY and TT motifs play important roles in the tissue-specific function of integrin, Data suggest that integrin alpha(2)beta(1), glycoprotein Ib and vWf interactions with collagen I and III contribute to platelet adhesion under high shear flow., DSCs-expressed CD82 up-regulates the expression of TIMP1 in an autocrine manner and inhibits the invasiveness of human first-trimester trophoblast cells partly through the integrinbeta1/MAPK/MAPK3/1 signaling pathway, Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1., Increased uPAR expression promotes alpha(3)beta(1) integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors., the binding of filamin A to vimentin and protein kinase C epsilon is an essential regulatory step for the trafficking and activation of beta1 integrins and cell spreading on collagen, Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Data show that the L-plastin/integrin complex is regulated by mu-calpain cleavage and is not directly dissociated by calcium., Integrins may initiate the cellular response of osteocytes to dynamic fluid flow and may serve as mechanosensitive molecules in bone., The results demonstrate definitely that major quaternary rearrangements of beta1-integrin subunits occur in adherent cells and that conversion from a bent to extended form takes place at focal adhesions., Pancreatic beta cell mesenchymal transition and decline in insulin gene expression are induced by elements of the ECM, by b1-integrin ligation, and by signaling via Src, JNK, and ERK., The expression of Integrin beta1 decreases when the differentiation level of squamous cell carcinoma cells increase., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., Indicate that the integrin beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures., Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function., Inhibition of integrin beta1 reduced the adhesion forces of trophoblast cells to type I rat collagen or endothelial cells., Measurement of thrombus height after specific receptor blockade or use of altered proportions of peptides indicates a signaling rather than adhesive role for glycoprotein VI, and primarily adhesive roles for both alpha(2)beta(1) and the VWF axis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, The results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix., Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways., alpha4beta1-mediated tumor lymphangiogenesis promotes metastasis, Activation of ss1-integrin in human umbiilical vein endothelial cells (HUVEC) is specifically affected by depletion of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)., The authors identify beta(1) integrin, which is expressed by naive B cells of distinct lymphoid origin and by memory B cells from nasal mucosa-associated lymphoid tissue, as a mediator of increased susceptibility to infection by Epstein-Barr virus., Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion., up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions, Integrin beta 1 may play an important role in the development of hepatic fibrosis, hepatic cirrhosis and hepatocellular carcinoma., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Prostate tissue-derived CD133+ cells exhibited a high level of expression of beta1 integrin, The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., Inhibition of beta1 integrin function rescued proliferation and cyclin E1 expression as well as c-Myc expression and Rb phosphorylation., when beta(1)A is unligated, beta(1)B is responsible for "integrin-mediated death" in human keratinocytes, Recombinant or microparticle-associated tissue factor stimulate endothelial cell proliferation through activation of the ERK 1/2 pathway, mediated through a novel mechanism requiring the interaction of exogenous TF with cell surface beta1-integrin., Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration., Eight different anti-integrin beta1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed., Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, decreasing beta1 chain causes alphavbeta3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity., Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis., The HCMV gB-DLD protein bound to fibroblasts in a specific, dose-dependent and saturable manner that required the expression of an intact beta1 integrin ectodomain., alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, Findings argue strongly that beta1-integrin can both potentiate CMG2-mediated endocytosis and serve independently as a low-affinity PA receptor., plays a key role in the pathogenesis of pustulosis Palmaris et Plantaris, Calcium regulates integrin beta1 activity and expression and cell migration of HaCaT cells., Inhibition of beta1 integrin expression by DNAzyme to beta1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro., The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration., our data indicate that CCR7 regulate cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck, SIRPalpha facilitates cross-talk between the prolactin receptor (PRLr) and beta1 integrin and provides a basis for extracellular matrix regulation of PRLr action in breast cancer., Data confirmed reduced CD9 expression in MDS CD34+ and bone marrow mononuclear cells., U937 macrophage responses to the TLR2 ligand, Pam3CSK4, are dependent upon integrin alpha3beta1., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., Data show that coculture of ALL cells with MSCs induced on the lymphoblast plasma membrane the expression of a signaling complex formed by hERG1, the beta(1)-integrin subunit, and the chemokine receptor CXCR4., Data suggest that up-regulation of integrin beta1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2., Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction., the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells, Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression., Both wild-type and internal tandem duplication (ITD)-FLT3 proteins co-immunoprecipitated with beta1 integrin and Pyk2 indicating the signal crosstalk between FLT3, beta1 integrin and Pyk2., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions., Structural diversity in integrin/talin interactions., alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival, ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, investigation of role of ITGB1 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors., Data show that interactions between beta1 integrin and ErbB4 occur in a spatiotemporally-regulated manner, and such interaction contributes to the integrin-dependent cell migration., Ameloblastoma cells proliferate and are differentiated by capturing perlecan differentially with alpha-dystroglycan and integrin beta1, respectively, expression of VLA-4 in PBMC of hemorrhagic fever with renal syndrome (HFRS) patients at different stages were higher than normal controls, except recovery stage; VLA-4 might play an important role in the immunopathological lesions of HFRS, These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways., High expression levels of CD151 and alpha6 promote invasiveness of HCC cells. Either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC., Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells., kindlin-2 promotes integrin b1 and b3 activation., expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection., The extra nuclear AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. Assembly of this ternary complex may control organ development and prostate cancer metastasis., Data suggest that integrin alpha6beta1 is an important cell surface receptor that mediates the adhesion of the SMMC-7721 hepatocellular carcinoma cell line to type IV collagen., stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream beta1 integrin function, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., High integrin beta 1 is associated with invasive lobular cancer in comparison with other breast tumor types., a novel mechanism by which beta1 integrin regulates matrix metalloproteinase-10 expression during lymphatic vessel remodeling, Significant to anoikis-related regulation, the delay in caspase-8 activation was accompanied by the maintenance of FAK Tyr397 phosphorylation, integrin beta1-associated FAK and a FAK/caspase-8 complex., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., P-selectin, on eosinophil-associated activated platelets or acquired from plasma or from prior interactions with endothelial cells/platelets, activates eosinophil beta1 integrin, stimulating eosinophil adhesion to VCAM-1 and move to the airway in asthma., a direct interaction between the Oca-family member NadA and human beta1 integrins., in endothelial cells, ligation of alpha2beta1 and alpha6beta1 integrins induces the Notch pathway, and we disclose a novel role of basement membrane proteins in the processes controlling tip vs stalk cell selection, results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy., HOXD1 plays a significant role in endothelial cells functions by regulating the expression of ITGB1., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8, Pancreatic stellate cells radioprotect pancreatic cancer cells through beta1-integrin signaling, The effect of SDF-1 on colorectal cancer cell signaling and urokinase-type plasminogen activator (uPA) expression is mediated by the CXCR4/beta1 integrin axis., maspin, uPAR, and beta1 integrin co-immunoprecipitate, suggesting a novel maspin-uPA-uPAR-beta1 integrin mega-complex that regulates mammary epithelial cell adhesion., these findings show that epithelial-mesenchymal transition and its down-regulated expression of E-cad circumvent breast cancer dormancy in part by facilitating beta1 integrin expression necessary for metastatic outgrowth., High serum ITGB1 is associated with gastric cancer., The results showed that overexpression of Id1 enhanced cell migration and increased beta1-integrin expression, In osteoblasts exposed to dexamethasone, ILK expression was slightly increased, whereas there was substantial reduction in that of beta1 integrin., Both DCC and integrin bindings interfere with microtubule binding to myosin X., Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1., data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88, Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces., Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., beta1 integrin-mediated adhesion is upregulated during T lymphocyte extravasation by activating Galpha subunit-dependent inside-out signaling., MSC migration is controlled by CD73 & CD29, which in turn are regulated by mechanical stimulation of cells, elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins., when lung fibroblasts are attached to collagen matrix, the beta1 integrin/Src/PP2A-mediated 4EBP-1 regulatory pathway is activated, Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase)., The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells., Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators., These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration., SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations., Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner., In malignant melanoma, CD147/basigin regulates integrin beta1 signaling via the phosphorylation of focal adhesion kinase., There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration, Talin1 is required for inside-out activation of integrin beta1 during Bartonella henselae infection., Left ventricular assist device-induced reversed remodeling did not result in significant integrin protein expression, although changes in integrin mRNA expression suggested an adaptation to unloading., WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells., the integrin beta1 signaling pathway has an important role in regulating the nanofiber-induced fibroblast phenotypic alteration, examined integrin beta(1) , ECAD and rac1 expression in SCLC and analyzed the prognostic value of these markers, a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route, Results demonstrate differential effects of Snail and Slug in pancreatic cancer and identify the interplay between Rho signaling and beta1-integrin that regulates the scattering and migration of Snail- and Slug-expressing pancreatic cancer cells., Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., these data collectively indicate that beta1-integrin-related cell death is closely associated with EMT phenotypes and activation of the p53-p21 pathway is partly involved in the acquisition of resistance to apoptosis induced by beta1-integrin silencing., uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells, IGFBP2 activates integrin beta1 and downstream invasion pathways. The IGFBP2/integrin/ILK/NF-kappaB network functions as a physiologically active signaling pathway in vivo by driving glioma progression., Recombinant expression plasmid integrin-beta1- shRNA can inhibit the expression of integrin-beta1 gene and suppress the invasion of pancreatic carcinoma cells in vitro significantly., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression, The expression of beta1-integrin in glia is crucial for the proper development of the cerebellar cortex, whereas its expression in granule neurons is dispensable for cerebellar development., Dephosphorylation of FAK upon inhibition of beta integrin resulted in dissociation of a FAK/cortactin protein complex. This, in turn, downregulated JNK signaling and induced cell rounding, leading to radiosensitization., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer., analysis of the role of RICTOR in beta1 integrin-mediated cell survival and how receptor-specific mechanisms regulate phosphorylation of AKT at Ser473, Integrin beta1-mediated cellular adhesion to fibronectin confers drug resistance to mitomycin-C on bladder cancer cells. Knockdown of integrin beta1 may abolish the drug resistance phenotype and sensitize bladder cells to mitomycin-C., This study demonstrates that integrin beta1 mediates EGF-induced cell invasion in ovarian cancer., demonstrate with loss-of-function and rescue experiments that CD9 activates and MMP8 inactivates beta1 integrins and that both proteins associate with beta1 integrins in cells, The findings indicated that integrin a6b1 promotes the survival of brain endothelial cells by inhibiting prodeath signaling by TNF-R1, in part by inducing cellular FLICE inhibitory protein expression., Integrin b1/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial cells., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin beta1 sialylation, crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, The number of glycine residues in the PH domain is the key difference underlying the differential actions of cytohesin 2/ARNO and cytohesin 3/GRP1 in cell adhesion, spreading and beta1 integrin recycling., describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, The live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton., Integrin beta1 mediates vaccinia virus entry through activation of PI3K/Akt signaling., Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin., beta1 integrins should sense the stimulation of fluid shear stress and thus activate ERK1/2 through activating of FAK., The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome., decreased GnT-V activity due to inflammatory cytokine induction in human monocytes resulted in enchancement of integrin alpha5beta1-dependent monocyte-vascular endothelium adhesion and transmigration, There is no association between platelet collagen receptor polymorphisms GP VI T13254C or GP Ia C807T (alpha2beta1Integrin) and premature acute myocardial infarction in the Iranian population., These data suggest that Dab2-mediated recruitment of EH domain proteins selectively drives the internalization of the Dab2 cargo, integrin b1., Kindlin-2 and talin head do not interact with one another but can bind simultaneously to the integrin beta(3) tail without enhancing or inhibiting the interaction of the other binding partner., The regulation of alpha4beta1-dependent adhesion and migration of myeloma cells by CXCL12-S1P combined activities might have important consequences for myeloma disease progression., alpha5beta1 integrin transgene demonstrates an important angiogenic role by promoting brain endothelial cell proliferation in response to cerebral hypoxia., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit, Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., Combination of CD29 and CD44 can be used as markers to enrich cancer stem cells in human squamous cell carcinoma with epithelial-mesenchymal transition., These findings indicate that integrin beta1 has a major impact on HNSCC prognosis through its regulation of metastasis., CD151 links alpha(3)beta(1)/alpha(6)beta(1) integrins to Ras, Rac1, and Cdc42 by promoting the formation of multimolecular complexes in the membrane, which leads to the up-regulation of adhesion-dependent small GTPase activation, Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation., Tauroursodeoxycholic acid can directly activate intrahepatocytic beta integrins, which trigger signal transduction pathways toward choleresis., It was shown that mutations in the integrin beta1 tail NPXY motifs in the kidney produce phenotypes different from those seen in constitutive and skin-specific knock-ins., Provide further evidence that beta1 integrin can be a marker of poor prognosis in breast cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., Most actinic cheilitis cases showed reduced expression of integrin beta1 and superficially invasive squamous cell carcinoma lacked intergrin beta1 in the invasive front., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., In astrocytes transfected with a chimeric beta1 subunit, its activation is sufficient to cause centrosome assembly in the absence of cell adhesion., Data indicate that alpha3beta1 and the tetraspanin CD151 directly associate at the front and retracting rear of polarised migrating breast carcinoma cells., while alpha5beta1 integrin cross-linking contributes to the bacillus Calmette-Guerin response, it alone is insufficient to duplicate the full spectrum of bacillus Calmette-Guerin induced changes in urothelial carcinoma cell biology., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth., Examined the role of beta1 integrin in exocrine pancreatic structure and function. Compared with control pancreata, beta1 integrin-deficient pancreata showed reduced mRNA expression of extracellular matrix (collagen type Ialpha2, fibronectin and laminin) genes., Data show that TIMP-2-mediated inhibition of vascular endothelial cell permeability involves an integrin alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association., Gal-3 expression enhances beta1 integrin-mediated cell adhesion and cell migration., The chemokine domain of fractalkine binds to integrins alpha4beta1 and alphavbeta3., Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation., NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in renal cell carcinomas malignancy., Beta1 integrin is the main target for Cdc42-mediating interaction of cancer cells with endothelial cells and the underlying extracellular matrix, as exogenous beta1 integrin expression was sufficient to rescue the Cdc42-silencing phenotype., Expression of alpha and beta integrin subunits is increased on peripheral blood T cells in patients with asthma, study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation, Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced intracellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-dependent Akt activation, Mechanotransduction through beta(1)-integrins, FAK and p38 is required for anti-inflammatory effects of steady shear stress., data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone., Data indicate that Slug siRNA suppressed the TGF-beta1-induced integrin alpha3beta1-mediated cell migration ability of squamous cell carcinoma HSC-4 cells., Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation., The role of beta1 integrins and of a beta1 downstream target, c-Jun amino-terminal kinase 1 (JNK1), in regulating radiation-induced apoptosis in prostate cancer was studied., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation., osteopontin, LAMB3 and ITGB1 played important roles in the occurrence and metastasis of lung cancer, thus provided important clues to understanding the molecular mechanism of metastasis., beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma., Aberrant expression of E-cadherin and integrin beta-1 is closely related to malignant transformation and hydatidiform mole development., a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported., Data suggest that ITGB1 is critical ligand to enhance cell-extracellular matrix contact force and thus promotes cell proliferation; ITGB1 knockdown affects leiomyomal cell spreading but not adhesion; ITGB1 may function in progression of leiomyoma., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, Timp1 is assembled in a supramolecular complex containing CD63 and beta1-integrins along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway., Integrin beta1 interacts with SPARC in prostate cancer cells and suppresses cell proliferation and migration., provide the first evidence that beta(1) integrin-dependent migratory and metastatic competence of prostate cancer cells is enhanced by Trop-2, The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1., Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation., an important role of AnxA2 in controlling dynamics of beta1 integrin at the cell surface that in turn is required for the active turnover of cell-matrix associations, cell migration, and wound closure., Findings indicate that interactions between beta1-integrin and NF-kappaB p65 were induced in nonmalignant breast epithelial cells, but not in malignant cells, indicating context-specific regulation., Suggest that fibronectin fine tunes LM332-mediated migration by boosting bronchiolar cell adhesion to substrate via integrin alpha3beta1 integrin., High integrin beta 1 expression is associated with radioresistance in astrocytoma., Both CD9/CD81-silenced cells and CD151-silenced cells showed delayed alpha3beta1-dependent cell spreading on laminin-332., Integrin beta-1(+) and p75NTR(+) cells play an important role in wound healing process, MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, lipid raft integrity was required for beta1 integrin-mediated initial spreading of melanoma A375 cells on fibronectin., The data suggest that integrin beta1 is a potential biomarker for lymph node metastasis and prognosis of lung adenocarcinoma and integrin beta1 upregulation may play an important role in the pathogenesis of lung adenocarcinoma., These results showed evidence of Borrelia burgdorferi BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein., A specific association between alpha4beta1 and CD81, CD82 and CD151 was demonstrated and antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., changes in p38 mitogen-activated protein kinase expression together with recycling of adhesion receptors from the endosome leads to endothelial cell adhesion., These results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in beta1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells., 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., beta1-Integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer., These data uncover a potential role for PKP2 upstream of beta1 integrin and RhoA in integrating cell-cell and cell-substrate contact signaling in basal keratinocytes., integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion, NG2 knockdown results in loss of beta1 integrin activation in endothelial cells, revealing a mechanism for NG2-dependent cross talk between pericytes and endothelial cells., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, Expression of the VLA-4-stimulating factor sequence may help to predict melanoma prometastatic risk., Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., expression of beta1 integrin in OECM-1 cells is involved in the development of malignant phenotypes of OSCC, Data indicate that all mesenchymal colony clusters displayed a predominant CD44+/CD24- phenotype with decreased HER-2 expression and elevated levels of a beta1-integrin isoform with a high degree of N-glycosylation., CD44v6 and integrin-beta1 mRNA and protein expression in blood may serve as biomarkers for the development and metastasis of pancreatic cancer, Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells., Autophagy regulates cell migration, a central mechanism in cell development, angiogenesis, and tumor progression, by mitigating the cell surface expression of beta1 integrins., MARVELD1 plays a role in pre-mRNA processing of integrin beta1., the alpha1 integrin subunit in Bone marrow-derived mesenchymal stem cells is important for their ability to stimulate vessel morphogenesis., ss1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion., Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury., Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., The present study demonstrates miR-134-mediated negative regulation of beta1 integrin that influences cell adhesion to and of mesenchymal stem cells., Data indicate that levels of CXCR4 and VLA-4 did not predict acute lymphoblastic leukemia (ALL) prognosis in children, but Analysis of CXCR4 and VLA-4 levels at diagnosis in adults with ALL can provide useful information on patient prognosis., alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., Data show that nucleolin is a critical lipid-raft-dependent beta1-integrin-interacting protein in A375 melanoma cell spreading and migration on fibronectin., High VLA-4 expression is associated with brain metastasis., data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells., Data indicate that macrophage-derived exosomes regulate integrin beta1-dependent migration of endothelial cells., beta1 integrin signaling in human epithelial progenitor cell, SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin beta1 signaling pathway in hepatocellular carcinoma., beta-1,4-Galactosyltransferase III suppresses beta1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer., beta1 integrin expression represents a reliable prognostic factor regarding the grading of liver metastases of colorectal cancer, Integrin alpha3beta1 mediates regulation of COX2 mRNA stability in human breast cancer cells., ITGB1 enhances epithelial-mesenchymal transition via FAK-AKT signaling pathways., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, In high grade malignant tumors (G1), CDH1 and ITGB1 gene expression was the highest, in G2 and G3 tumors the expression of both genes was gradually lowering, mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the b1-integrin/ILK pathway., Data indicate that miR-134 suppressed the invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134., Low integrin beta 1 is associated with migration and invasion of colorectal cancer., Suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in airway epuithelial cells., Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive., Results indicate that the signaling critical to epithelial-to-mesenchymal transition (EMT) is regulated by the beta6 integrin cytoplasmic domain., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., beta1 integrin participates in calreticulin (CRT)-mediated cell adhesion in J82 human bladder cancer cells., These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways., VCAM-1/VLA-4-dependent activation of NF-kappaB has a role in mediating chemoresistance in leukemia cells, the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety, Data suggest that TIMP1 (tissue inhibitor of metalloproteinase-1) acts as chemoattractant for neural stem cells (NSC); TIMP1 enhances NSC adhesion, migration, and cytoskeletal reorganization; these effects are dependent on CD29/CD63 (granulophysin)., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation., the expression of integrin beta1 protein in cervical SCC tissues was significantly higher than that in the normal cervical tissues, and it increased with the clinical stage and the degree of malignancy., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, a Rap1A/beta1 integrin pathway, activated downstream of G-protein-coupled receptor stimulation and RhoA, in glioblastoma cell proliferation., phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that increases metastatic potential of prostate cancer cells., Results suggest that ITGB1 regulates the growth and apoptosis of human colorectal cancer cells., circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells., It plays a role in regulation of leukocyte migration to a site of inflammation., These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells., ITGB1 upregulation is involved in tumorigenesis and disease exacerbation by inflammatory cytokines as IL-6, TGF-beta1 and SDF-1, and targeting ITGB1 and the inflammatory modulator is a strategy for therapeutic intervention of ovarian carcinogenesis., abundance of LMTK3 positively correlated with that of the integrin beta1 subunit in breast cancer patient's tumors, Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543, When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., diabetic retinopathy is associated with ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension., C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity., Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 protein levels in prostate cancer cells, and increased lethality., lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier, Integrin beta1 and VEGF are overexpressed and microvascular density is increased in hypopharyngeal squamous cell carcinomas., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1., indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Data show that fluvastatin (FLV) attenuated the podocyte injury induced by puromycin aminonucleoside (PAN) and increased the production of beta1 integrin in podocytes., Data indicate that the interaction between S100A6 and integrin beta1, was confirmed by ELISA., Low NAMPT is associated with upregulation of beta1-integrin in breast tumor cells., The stimulatory cues of matrix rigidity were driven by b1 integrin mechano-sensing through FAK (pY397), and were associated with a posttranscriptionally driven rise in b1 integrin expression, This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway, CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility., our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling, The carbon monoxide signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand., Baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways., we demonstrate that beta1 integrins have a pivotal role in breast cancer bone colonization using unique tissue-engineered humanized bone models., The cytoplasmic tail of human integrin beta-1 contributes to fibroblast cell adhesion forces., role in stretch-induced renal fibrosis through the activation of c-Src and STAT3 signaling pathways, it is not just inactivation of Fyn that promotes multicellular spheroid formation but this must be coupled with the full length beta6 integrin., integrin alpha8beta1 has a protective role in arterial remodelling and atherosclerosis, These data provide evidence for CD147 as an important determinant of radioresistance via the regulation of integrin beta1 signaling., PCTK1-KAP0-myosin X-integrin beta 1 is a functional module providing a link between ECM and the actin cytoskeleton in the cell-extracellular matrix (ECM)-dependent control of spindle orientation., Data suggest expression of B4GALT3 in placenta is up-regulated in third trimester; overexpression of B4GALT3 suppresses trophoblast migration and enhances glycosylation of ITGB1; stability of ITGB1 may regulate trophoblast invasion in late pregnancy., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts., Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway., a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, an 'in solution' steady state organic fluorophore based quantitative fluorescence resonance energy transfer (FRET) assay to quantify VLA-4/VCAM-1 interaction., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway., DPP-4 and integrin beta1 interactions regulate key endothelial cell signal transduction in both physiological and pathological conditions including endothelial mesenchymal transformation., Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis., Hyperhomocysteinemia reduces BM CD34(+)/VEGFR2(+) generation and suppresses CD34(+)/VEGFR2(+) cell mobilization and homing to the injured vessel via beta1-integrin inhibition, which contributes to impaired re-endothelialization and vascular remodeling., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., ITGB1 SNPs might be a prognostic biomarker for CRC., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., the association between two genetic polymorphisms located in the VLA4 gene and the risk of multiple sclerosis, was investigated., HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion., CD105 and CD29 immunoexpression in decidua basalis, fetal membrane and placental villi showed significant negative correlations with the maternal age, This paper finds a regulatory role for beta1 integrins in the repair of radiogenic DNA damage via classical non-homologous end joining., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-related biological processes, Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship, We propose that PrP modulates beta1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin, and through the regulation of ERM-mediated membrane-cytoskeleton linkage., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma., based on the interaction motifs in Sdc1 and Sdc4, called synstatins (SSTN210-240 and SSTN87-131) competitively displace the receptor tyrosine kinase and alpha3beta1 integrin from the syndecan with an IC50 of 100-300 nm, Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility., HPW-RX40 restores the anoikis sensitivity in the metastatic breast cancer cells by inhibiting integrin beta1 and subsequent FAK activation., blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow, CXCL12/CXCR4 activation by cancer-associated fibroblasts mediated integrin beta1 clustering at the cell surface and promoted the invasive ability of gastric cancer cells, the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion., Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration., Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes., Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling., establish a paradigm according to which retrograde trafficking, and not endosomal recycling, is the key driver for beta1 integrin function in highly polarized cells, These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane., knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased, Inhibition of integrin beta1 activation on the cortex and disruption of its asymmetric distribution leads to spindle misorientation., G-CSF stimulates beta1 integrin expression and Swan 71 cell migration by activating PI3K and MAPK signaling pathways., GM2 mediats tumor cell migration by interacting with ITGB1 leading to downstream signaling and the phosphorylation of ERK MAP kinases.,
OFFICIAL_GENE_SYMBOL ITGB1,
SP_COMMENT function:Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis., online information:CD29 entry, PTM:The cysteine residues are involved in intrachain disulfide bonds., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subcellular location:Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells., subunit:Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with RAB21., tissue specificity:Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).,
integrin subunit beta 3(ITGB3) integrin subunit beta 3(ITGB3) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q21.32,
ENSEMBL_GENE_ID ENSG00000259207, ENSG00000259753,
GENERIF_SUMMARY Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF., Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity., A naturally occurring point mutation in the beta3 integrin MIDAS-like domain affects differently alphavbeta3 and alphaIIIbbeta3 receptor function., Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3, Review. Alpha(v)beta3 integrins are involved in vascular repair processes. The challenge is to develop a therapeutic agent that will prove effective in reducing restenosis in humans following percutaneous coronary intervention (PCI)., GPIIb-IIIa complexes are not in an activated conformational state after dissociation of abciximab unless there is an additional source of activation., beta3-Integrin expression was directly up-regulated by HOXA10 in the endometrium, location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron, A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia prevents GPIIbIIIa from binding fibrinogen when platelets are activated., Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions (Integrin alpha-v beta-3), Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton, Del1 mediates vascular smooth muscle cell adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)., Immunohistochemical analysis of human tumor sections from several organs showed a heterogeneus distribution of CD61 in metastatic cases from colon and breast carcinoma. However, no staining was found in metastasis from melanoma., Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton (integrin alpha(IIb)beta(3)), Site-directed mutagenesis of residues on the top surface of the integrin beta3 I-domain that contains a putative ligand binding site identified D158 and N215 as novel residues critical for ligand binding., Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins., A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia, collagen receptor glycoprotein VI and alphaIIbbeta3 trigger distinct patterns of receptor signalling in platelets, leading to tyrosine phosphorylation of PLCgamma2 (integrin alphaiibbeta3), Integrin alpha IIbbeta 3 has agonist-specific activation states and causes intrasubunit and intersubunit allosteric effects, Two different beta3 cysteine substitutions alter alphaIIb beta3 maturation and result in Glanzmann thrombasthenia., Integrin-linked kinase transiently associates with and phosphorylates beta3, regulating platelet integrin alphaIIb beta3 in a PI3-kinase dependent manner, Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma., integrin alphaVbeta3 expression is reduced when ROR alpha is activated in prostate cancer cells, Integrin alphavbeta3. Expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells, Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes., Role for beta3 integrins in human melanoma growth and survival., alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts, regulation of integrin function by CD47 ligands, phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) engagement, promotion of integrin alpha Vbeta 3-dependent endothelial cell adhesion by PGE2, co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium, Data show clearly that integrin alpha(v)beta(3) interacts with the latency-associated peptide (LAPbeta1 and 3) RGD motif., role in mediating pro-angiogenic activity of CYR61, An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis., in patients with endometriosis a significant negative correlation was observed between luminal expression of eNOS and alpha(v)beta(3) integrin and between glandular expression of eNOS and luminal expression of alpha(v)beta(3) integrin, thrombin interacts with alphavbeta3 as demonstrated by direct binding of alphavbeta3 protein to immobilized thrombin., a 17-amino acid sequence is identified as a common epitope for antibodies associated with quinine-induced immune thrombocytopenia, activation state of alphaVbeta3 integrin is an important regulator of the duration of insulin-like growth factor I receptor phosphorylation and this regulation is mediated through changes in the subcellular localization of SHP-2, Ligand binding promotes the entropy-driven oligomerization of this protein, Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., role of Pro33 polymorphism in enhanced activation of mitogen-activated protein kinase and myosin light chain kinase, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, Integrin alphaiibbeta3 plays a role in signal transduction that leads to a defect in leukocyte adhesion, has a role in the early phase of liver metastasis, possible association between the GPIIb/IIIa PIA1/A2 polymorphism and the occurrence of cryptogenic stroke in young patients, data suggest that despite partial disruption of calf-1 or calf-2 domain by mutation in Glanzmann thrombasthenia, glycoprotein IIb/IIIa complex is formed but its transport from the endoplasmic reticulum is impaired, Review. A signal is initiated at the cytoplasmic tail to transform the extracellular domain of alphaIIbbeta3 into a functional receptor for fibrinogen or von Willebrand factor to support platelet aggregation & thrombus formation., thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, decreased expression of endometrial integrin alphavbeta3 suggests that functional, but not morphological, endometrial defect may be one of the causes for the patients with unexplained infertility and recurrent IVF-ET failures, Alphavbeta3 integrin expression and pinopode formation in human endometrium are processes closely related to endometrial maturation; unlikely as targets for contraceptive approaches or fertility-promoting strategies, Intercellular calcium communication is primarily mediated by a signaling mechanism operating between this protein, ITGA2B and the adenosine diphosphate purinergic receptor P2Y12., tumstatin binds to alpha v beta 3 integrin in a vitronectin/fibronectin/RGD cyclic peptide independent manner, in megakaryocytes turbulence induces Rap1 activation that controls alphaIIbbeta3-mediated cell adhesion, role of polymorphisms in cardiovascular thrombotic disease [review], Data suggest that this alphavbeta3 binding to alpha5-laminins is involved in the regulation of cellular responses to growth factors known to be involved in epithelial and endothelial development., This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., binding of thrombin to GPIbalpha induces fibrin binding to resting alphaIIbbeta3 leading to fibrin-dependent platelet aggregation and clot retraction, that can be selectively inhibited by alphaIIbbeta3 antagonists, results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation; results also suggest a structural basis for the coincidence of integrin activation and clustering, the extracellular Ig domain of IAP(CD47), when bound to thrombospondin, interacts with integrin alphaIIbbeta3 and can change alphaIIbbeta3 in a high affinity state without the requirement of intracellular signaling, signaling through JAM-1 and alphavbeta3 is necessary for bFGF-induced angiogenesis., Data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals., alphavbeta3 expression in LNCaP (beta3-LNCaP) prostate cancer cells causes increased cdc2 mRNA levels as evaluated by gene expression analysis, and increased cdc2 protein and kinase activity levels, identification of binding site in gamma C-domain of fibrinogen, alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, Low concentrations of agonists resulted in enhanced platelet aggregation in subjects with the GNB3 CC-genotype compared to carriers of a 825T-allele., relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation, analyzed the possible cooperation effect between the PlA2 allele (GPIIIa) and LL genotype (SLC6A4) in the development of myocardial infarction, high prevalence of the HPA-1b allele of beta3 in Glanzmann thrombasthenia, integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, Individuals homozygous for the Leu33Pro polymorphism of the beta3 integrin subunit have an increased cancer risk., Glycoprotein IIb/IIIa has a role in platelet-activating factor-induced platelet activation with protein kinase C activity, the 749EATSTFT756N and 755TNITYRG762T regions of beta3 contribute to the regulation of alphaIIbbeta3 anchorage to the cytoskeleton and platelet spreading to an adhesive surface, beta3 integrin has a role in causing structural rearrangements of the 10-23 DNAzyme, predictions of hydrophilicity, surface accessibility and antigenicity and the three dimensional structure of the beta(3) integrin correlate with autoantibody binding to a recombinant GPIIIa peptide 'B' containing residues 468-691., increased expression of the alpha(v)beta(3) integrin during breast cancer progression can make tumor cells more responsive to malignancy-promoting ligands such as OPN and result in increased tumor cell aggressiveness., the E749ATSTFTN756 region of the beta3-tail stabilizes the binding of soluble and surface-bound ligand to integrin alphaIIbbeta3 via a mechanism that involves the phosphorylation of FAK, integrin alpha(v)beta3 has an important role in bone metabolism and angiogenesis, and in controlling growth of metastatic prostate cancer cells in the bone, proteins regulated by CBFA2 are required for inside-out signal transduction-dependent activation of GPIIb-IIIa, results invoke a model whereby Src is primed for activation by direct interaction with an integrin beta tail, and integrin clustering stabilizes activated Src by inducing intermolecular autophosphorylation, The mutation at the position 29 107 of intron 10, G-->T, in the beta3 genomic DNA was found to induce an aberrant splicing and to be responsible for Glanzmann's thrombasthenia in this patient, activation of the beta subunit I-like domain of integrin beta3 is analogous to that of the alpha subunit I domain, Cysteine residues in the epidermal growth factor domains of the beta3 subunit are important for the ligand binding activity of the integrin alphaIIbbeta3 complex., CD47-alpha(v)beta(3) interactions that lead to integrin clustering are detergent resistant and do not require cholesterol or the transmembrane region of CD47, alphavbeta3 integrin has a role in regulating proliferation and apoptosis of hepatic stellate cells, in the absence of GPIbalpha or following inhibition of thrombin binding to GPIbalpha, there is a reduction in the thrombin-induced calcium flux, beta3 cleavage and micro -calpain activation., analysis of the three-dimensional model of integrin alphaIIbbeta3, APOC3, LPL and GpIIIa genes were found to be associated with BP levels. The contributions of these genes, although modest, are consistent with the polygenic nature of blood pressure levels., integrin alpha(IIb)beta3 adhesive function is regulated by platelet FXIII and calpain, This review discusses the major role played by glycoprotein IIb/IIIa (GPIIb/IIIa) in the regulation of platelet adhesion and aggregation during hemostasis., alpha IIb beta 3 signaling in platelets is regulated by SHIP1 and Lyn kinase, GpIIIa gene polymorphism as a risk factor for stroke caused by large vessel disease in males., results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect, For HPA-1 gene polymorphism, only the HPA-1a/a (PlA1/A1) genotype was observed in Korean population cardiac patients, secondary structure analysis of integrin alphaVbeta3, The HPA-1b (PlA2) allele significantly protected against subarachnoid hemorrhage., analysis of F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa in human platelets, Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor., beta3 integrins play important roles during transendothelial migration of PC3 cells while interacting with the matrix underneath the endothelium. These interactions are independent of the ability to cluster beta3 integrins into focal adhesions., CEACAM1 and alpha(v)beta(3) integrin are functionally interconnected with respect to the invasive growth of melanomas, PlA1/A2 polymorphism of platelet glycoprotein IIIa (GPIIIa) has is not implicated in the pathogenesis of type 2 diabetes., A novel 465T-->C (S123P) mutation in exon 3 interfered with the platelet aggregation in a manner similar to Glanzmann's thrombasthenia., Inheritance of the integrin beta3 Leu33Pro polymorphism may increase the breast cancer risk by age 45 in the German population., a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia, The Integrin beta3 receptor is expressed on almost all cells originating from the mesenchyme and seem to mediate several biological processes, including adhesion of osteoblasts to the bone matrix., Mu-calpain is activated in human endometrial cells during hypoxia and that subsequent cleavage of the integrin beta3 cytoplasmic domain may give some adverse effects to the function of human endometrium, Pyk2 is a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskele, there is a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion, integrin alphaIIbbeta3 has a role in mechanotransduction for shear activation of platelets, alphaIIb-mediated outside-in signaling resulting in TxA(2) production and granule secretion is negatively regulated by a sequence of residues in the membrane distal beta3 cytoplasmic domain sequence RKEFAKFEEER., association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene, Of the 22 Glanzmann thrombasthenia patients studied, mutations were detected in 12 individuals. Of these, 11 were novel mutations., We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution., This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens., dephosphorylation events play a role via serine/threonine phosphatases during the integrin outside-in signaling mechanism, and the Leu(33) --> Pro polymorphism regulates this process, Epidermal growth factor receptor and alphavbeta3 work together as coreceptors for Human cytomegalovirus entry and signaling., variation in ITGB3 in addition to Leu33Pro could contribute to susceptibility to cardiovacular disease and serotonin in a sex-specific manner, Results support the hypothesis that carriers of the GP IIIa PlA2 allele might have an increased risk for acute coronary syndrome in Hungarian population., SHPS-1 negatively regulates platelet function via CD47, especially alpha(IIb)beta(3)-mediated outside-in signaling, TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B, an apparently silent beta3 mutation results in aberrant splicing and reduced beta3 mRNA and may play a causative role in Type I Glanzmann thrombasthenia, electron tomography analysis of the three-dimensional structure of integrin alphaIIbbeta3 in the active state, PI3-K and calcium oscillation are synergistically operated and form a positive-feedback regulation in integrin alpha(IIb)beta3-mediated outside-in signaling, Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3, reactive oxygen species produced in platelets significantly affected alphaIIbbeta3 integrin activation, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Highest expression of alphavbeta3 integrin is associated with metastatic potential of osteosarcoma cells by enhancing the ability of the cells to migrate specifically to the lung, the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets, GPVI and integrin alphaIIb beta3 have roles in signaling during platelet adhesion and platelet aggregation [review], Data show that alpha(v)beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src-dependent manner, and this activation is required for motogenic activity of Tat in endothelial cells., ITGbeta3 subunit cytoplasmic domains require membrane anchorage and the NPXY motif to recruit to adhesion complexes, Data show that protein-tyrosine phosphatase (PTP)-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 integrin signaling in platelets., Glycoprotein IIIa allele has been found in many studies to associate with risk of thrombosis., alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy, The 177-184 sequence of beta3 is necessary for vitronectin binding to alphaVbeta3., Cells overexpressing beta3 integrin can bind human ADAM12 via beta3 integrin., PI3K and granular released ADP in coordinating the feedback regulations in integrin alpha(IIb)beta3-mediated platelet activation, beta3 knockout mice transfused with wild-type platelets generated specific anti-beta3 antibodies which were able to induce thrombocytopenia in wild-type mice., ITGB3 gene polymorphisms is associated with breast cancer, Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer., analysis of platelet integrin alphaIIbbeta3 structure and function (review), the beta3 integrin gene is the direct target of NFAT1 in osteoclast formation, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, three beta-propeller mutations do not affect the production of pro-alpha(IIb), its ability to complex with beta3, or its stability, but do cause variable defects in transport of pro-alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi, Our results did not show the causative relationship between the existence of platelets GP IIIa mutations and venous system thrombosis in the women in labor., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption, The endometrial expression of beta3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation., Inhibition of alphaIIbbeta3 activation by NAD(P)H oxidase inhibitors and superoxide scavengers was independent of NO/cGMP signaling demonstrating a direct role of platelet NAD(P)H oxidase-generated ROS for integrin alphaIIbbeta3 activation., T cells from kidney allograft recipients can express significant amounts of alpha-beta 3 integrin (CD41/CD61., These results establish the beta3 gene as a direct target of NFATc1 in RANKL-dependent osteoclast formation., Increase in the affinity of alphaIIb beta3-mediated cell adhesion through binding to calcium- and integrin-binding protein following agonist stimulation is impaired in patients because of mutations., the Pro33 isoform of purified integrin alphaIIbbeta3 has increased fibrinogen and prothrombin binding, P-selectin expression, but not activated GPIIb/IIIa, is enhanced in ADP-activated platelets in the inflammatory stage of Takayasu's arteritis. SELP may play a significant role in the inflammatory and thrombotic responses associated with intractable TA, Results describe the multifunctional behavior of integrins, including integrin beta 3, based on their modification potential at hydroxyl groups of amino acids as a source of interplay., while the C-terminal region of the alpha(IIb) tail minimally influences alpha(IIb)beta(3) activation, the C-terminal region of the beta(3) tail is critically involved, Data showed that ITGB3 and SLC6A4 expression levels are correlated., analysis of metal-binding sites in the integrin beta3 A-domain, we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018)., integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins, binding of resveratrol to integrin alphaVbeta3, principally to the beta3 monomer, is essential for transduction of the stilbene signal into p53-dependent apoptosis of breast cancer cells., PET Molecular imaging of alpha(v)beta3 expression with [18F]Galacto-RGD in humans correlates with alpha(v)beta3 expression as determined by immunohistochemistry., Results suggest that shear stress directly modulates alpha(IIb)beta(3) function and that the shear-induced signaling contributes to regulation of platelet aggregation by directing the release of constraining cytoskeletal elements from the beta(3)-tail., beta3 integrin alters TGF-beta signaling in mammary epithelial cells via Src-mediated TbetaR-II tyrosine phosphorylation, which significantly enhanced the ability of TGF-beta to induce epithelial to mesenchymal transition and invasion., interactions between alphaIIbbeta3 & ligands echistatin & fibrinogen's gamma-module; studies differentiate priming ligands, which bind to resting receptor & perturb its conformation, from regulated ligands, where binding-site remodeling must first occur, analysis of platelet integrin alphaIIbbeta3 mutations that may play a role in Glanzmann thrombasthenia, Protein kinase C delta is positively regulated by platelet alpha IIb beta 3 outside-in signaling in platelet function., Tyrosine phosphorylation of beta3 promotes integrin outside-in signaling, by which the timing and location of calpain cleavage of integrins are dynamically regulated., N-cadherin and beta3 integrin expression correlates with progression to advanced-stage melanoma., platelet alphaIIbbeta3 is activated by an exogenous peptide corresponding to the transmembrane domain of alphaIIb, The transition from a locally invasive phenotype to a metastatic phenotype may be primed by the elevated expression of alpha(v)beta(3) receptors in prostate cancer cells., Cell surface expression of alphavbeta5 resulted in an attenuation of alphavbeta3-mediated migration on vitronectin, results demonstrate differential modes of regulation of Dok1 and Dok2 in platelets, and raise the possibility that Dok2 plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3, Transduction of beta3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to denatured collagen (gelatin)., identifies integrin alphaVbeta6 as a novel cellular receptor for fibrillin-1 with a K(d) of approximately 0.45 mum, type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells, beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed, SLC6A4 and ITGB3 gene interactions have roles in autism etiology and in serotonin level determination, The ITGB3_Leu33Pro polymorphism may potentially increase the risk of ovarian cancer in Polish women with an inherited BRCA1 mutation., Inhibition of integrin alphavbeta3 leads to abrogation of migration of HSC stimulated with PDGF-BB and to an antifibrogenic gene expression pattern., Individuals homozygous for the integrin beta3 Leu33Pro polymorphism have a two-fold risk of hip fracture, mainly confined to postmenopausal women., T cells epitopes on Glycoprotein IIIa., data suggest that the Pl(A2) polymorphism is a genetic determinant of ischemic stroke in a selected high-risk hypertensive population, the surface density of fibrinogen affects alpha II b beta 3-mediated platelet signaling, adhesion, and spreading, All patients with ISSNHL should undergo a comprehensive hematologic investigation of inherited and acquired prothrombotic factors, including platelet and V Leiden mutations, to identify a subset of patients at high risk of recurrent HL., in patients with stable coronary artery disease, an increased platelet reactivity after exercise, is specifically associated with an increased expression of platelet GP IIb/IIIa receptor, No association between GpIIIa polymorphism with either type 2 diabetes or ST elevation acute myocardial infarction., Prostate cancer cells expressing fully functional but not dysregulated alphavbeta3 integrin are able to control their own adherence and migration to bone matrix, functions that facilitate tumor growth and control bone lesion development., This is the first demonstration that NO directly regulates integrin beta(3) phosphorylation., Discussion of recent developments in elucidating the mechanism of integrin activation, with particular focus on the platelet integrin alphaIIbbeta3, is provided in this review, activation of ITGB3 transcription required a HoxA10 domain that was not identical to the "hexapeptide" that mediates interaction of Hox and Pbx proteins, Necl-5 has a critical role in integrin alphavbeta3 clustering and focal complex formation, integrins alphaLbeta2 and alphaIIbbeta3 are activated by mutation of a conserved asparagine in the I-like domain, OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin., Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion., Data show that in bullous pemphigoid, beta3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, Results suggest that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway., Significant associations between single nucleotide polymorphisms in ITGB3 and asthma, wheezing, and IgE levels suggest an early role for this gene in the development of asthma and allergy., Glycoprotein IIIa (GPIIIa, platelet antigen A1 and A2) polymorphisms that contribute to resistance or augmented response to aspirin are rare in the Chinese population., HPA-3b homozygotes have a tendency to develop ST segment elevation myocardial infarction instead of non-ST segment elevation infarction or unstable angina in acute coronary syndrome., Expression of the human ITGB3 subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and cell proliferation., separation of transmembrane domains is required for integrin outside-in signal transduction, establishes alphavbeta3 integrin as one key component of the transendothelial migration process of tumor cells, and as a potential target for anti-metastatic therapy, Regions of alpha(IIb) and beta(3) cytoplasmic tails, together with membrane segments of the subunits, contact each other to form a complex which restrains the integrin in a resting state. It is unclasping of this complex that induces integrin activation., c-Src controls functional association between integrin alphav-beta3 and VEGFR-2 via integrin beta3 phosphorylation., The PIA2 allele did not alter the beneficial effect of statins on blood coagulation., Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils, preliminary findings show that the HPA-6 A/B genotype is a risk factor for autoimmune thrombocytopenia in systemic lupus erythematosus, The proapoptotic ITGB3 cytoplasmic domain is rarely mutated in common human cancers and may not play an important role in the development of the cancers., Endometrial integrin beta3 and LIF expressions in the peri-implantation phase were significantly lower in stimulated cycles (including both moderate and high responders) compared to natural controls., Structural rearrangements undergone by integrin alpha(IIb)beta(3) after platelet activation were tested., effects of EDTA on GPIIb-IIIa dissociation and loss of adhesive functions are largely but not completely reve, macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells, analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton, Our findings show that A2/A2 homozygosity is associated with an increased risk of visual loss due to anterior ischemic optic neuritis in giant cell arteritis., Truncated beta3 may act as an anti-integrin and play a crucial role in cell migration, which is an important process in tumor invasion and metastasis., platelet glycoprotein IIb-IIIa number (evaluated as maximal binding of (125)I-labelled antibody CRC64) varied from 40.5 to 80.8 x 10(3) per platelet with no significant influence of platelet glycoprotein III a(GP IIIa) genotype., Fourteen of the antibodies reacted with a 29-kDa GPIIIa fragment comprising only the GPIIIa hybrid and plextrin-semaphorin-integrin homology domains, The specificity-determining loop was removed from the betaA domain & the mutations for HPA-4b,& -8,-6, -7, -10,-11,& -16bw antigens were introduced. The structural basis for their reactions with HPA-4 & HPA-bw antibodies was determined., oxidant systems external to platelets did not activate GP IIb/IIIa receptors while increased intra-platelet iron was associated with appearance of cytosolic oxidizing species and with GP IIb/IIIa receptor activation, The precise nature of the integrin beta 3 domains involved in the HPA-1a epitopes was studied by creating 8 soluble peptides & modeling their structures & interations with HPA-1a antibodies. Residues outside the PSI and hybrid domains are required., The ITGB3 GCC-Pro33 haplotype was associated with enhanced vWF activity, which may indicate ITGB3 haplotype influences endothelial function., the studies demonstrate that Vbeta3 is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)., a structural change in the conformation of anti-GPIIIa49-66 antibody contributes to its binding to the beta3 integrin and subsequent antibody-induced platelet fragmentation and aggregate dissolution, Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were found to be associated with the symptoms and recurrence of ischemic stroke., Report observed that alphav-beta3 integrins and Focal Adhesion Protein-Tyrosine Kinases co-localize and that fibrillin filament attachment sites to endothelial cells merge with these molecules., Novel ancestral mutation found in a cluster of Jordanian Glanzmann thrombasthenia patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3., Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma, uPAR is required to activate alphavbeta3 integrin in podocytes, promoting cell motility and activation of the small GTPases Cdc42 and Rac1, platelet activation and aggregation is regulated by MMP-2 that specifically interacts with integrin alpha(IIb)beta(3), Upon phosphorylation of Tyr 747 in the beta3 integrin tail, however, Dok1 then binds much more strongly than talin., Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon., the beta3 membrane-proximal and -distal residues cooperatively regulate talin-mediated alpha IIb beta3 activation., Functional and computational studies of the ligand-associated metal binding site of ITGB3 are reported., Data show that integrin beta3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of gastric carcinoma., Tyr178 of beta3 is critical for alphaIIb maturation and macromolecular ligand binding to alphaIIbbeta3, There was a significant association between the PlA2 polymorphism of GPIIIa and the risk of thrombosis in patients with HIT antibodies., tyrosine phosphorylation of GIT1 by Src kinases may regulate cytoskeletal reorganization downstream of alpha(IIb)beta(3) by bringing the Rac guanine nucleotide exchange factor betaPIX to the vicinity of the integrin, data show that the integrin beta 3 262T>C silent mutation is not restricted to a single family, as initially suggested, Thermodynamic data demonstrate that entropy is the dominant factor stabilizing lphaIIbbeta3, Integrin alpha v beta 3 plays a critical role in the S1P-stimulated chemotactic response of ECs., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., T(3) and T(4) hormones rapidly stimulate ERK activation in MG-63 cells via integrin alpha(V)beta(3) and that one functional effect of this ERK activation is increased DNA synthesis, In conclusion, agglucetin, acting as a survival factor, promotes endothelial adhesion and angiogenesis by triggering alphavbeta3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway., The numbers of antibody-binding sites of CD41, CD41a, CD41b, and CD61 on platelets of aplastic anemia patients and in idiopathic thrombocytopenic purpura patients, the numbers of sites for CD41 and CD41a were less than in normal controls., support an unsuspected role of alphaIIbbeta3/serotonin transporter(SERT)associations as well as alphaIIbbeta3 activation in control of SERT activity in vivo, nature of the lipid headgroup affected only the intracellular part of the transmembrane helix, indicating that an asymmetric lipid distribution is not required for studying the beta3 transmembrane segment, Mn(2+) simultaneously modulates the thiol isomerase activity of protein disulfide isomerase that is bound to alpha(V)beta(3) and induces its transition to the ligand-competent state, suggesting an alternative mechanism of integrin regulation, RN181 associates with the platelet-specific integrin alphaIIbbeta3 in human platelets through the conserved alphaIIb cytoplasmic KVGFFKR motif., Protein phosphatase 2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway, This study evaluated whether there was an association between 2 polymorphisms--the platelet glycoprotein (GP) IIIa PlA1/A2 and the endothelial nitric oxide synthase gene and a risk for nonvariceal upper GI bleeding in patients taking low-dose aspirin., Data show that in preeclamptic pregnancies, histamine does not stimulate expression of integrin alphaVbeta3, as it does in uncomplicated pergnancies., Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window., results demonstrate that TGFbeta1 induces alphavbeta3 integrin expression via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway, ROCK-dependent actomyosin-driven contractility is a critical determinant for the regulation of the interaction between Necl-5 and integrin alpha(V)beta(3)., HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Show that the Pl(A1/A2) polymorphism of Gp IIb/IIIa primarily affects the aggregation of platelets to monocytes in males., Data show no dramatic height change upon Mn(2+)-induced activation of membrane-bound integrins when compared with an inactive integrin control group., The results suggest that the intensity levels of platelet CD61 were elevated and associated with clinical phases and disease severity in patients with hemorrhagic fever with renal syndrome, CRP at levels found during episodes of inflammation directly binds to the activated form of alphaIIbbeta3 and inhibits platelet aggregation., integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling, Results identify kindlin-2 as a novel regulator of integrin beta3 activation; it functions as a coactivator., ITGB3 (beta3) DNA from a Va(a)-positive individual were sequenced and a single-nucleotide polymorphism (C622>T) in exon 5, resulting in the replacement of threonine with methionine at residue 195 was identified., Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses, osteopontin, Talin recruitment to alphaIIbbeta3 by RIAM mediates agonist-induced alphaIIbbeta3 activation, with implications for hemostasis and thrombosis., talin IBS2 binds to the same face of the beta3 subunit cytoplasmic helix as the integrin alphaIIb cytoplasmic tail helix, suggesting that IBS2 can only interact with the beta3 subunit following integrin activation., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, Ligand binding to platelet alphaIIbbeta3 induces integrin cytoplasmic domain-dependent phosphorylation of FcgammaRIIa, which then enlists selected components of the immunoreceptor signaling cascade to transmit amplification signals into the cell., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, GPIIIa Pl(A2) allele may be a genetic factor that contributes to the risk of sudden death from myocardial infarction in the absence of known risk factors, The presence of GPIIIa on this circulating trophoblast cellular material could be the source of HPA-1a alloantigen causing primary immunization of susceptible primigravidae, Factor XIII V34L, PAI-1, GPIIIa L33P, MTHFR C677T and MTHFR A1298C frequencies of genetic polymorphisms were found to be significantly higher among patients with idiopathic portal hypertension, the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas., The alphaIIb G236E mutation causes Glanzmann's thrombasthenia by impairing the association with beta3 during biogenesis of the receptor., UV-C appears to activate alphaIIbbeta3 not by affecting intracellular signal transduction, but by reduction of disulfide bonds regulating integrin conformation., SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway., The apo(a) component of Lp(a) signals through integrin alphaVbeta3 to activate endothelial cells., alpha3 integrin, despite its ability to respond to alternate ligands after wounding, does so through a single structure, the filopodia., Splenic macrophages that take up opsonized platelets via FcgammaRI are major APCs for cryptic GPIIb/IIIa peptides, and are central to the maintenance of anti-platelet autoantibody production in ITP patients, This report analyzed the molecular effects of an A>T substitution leading to an amino acid change, D217>V, in the beta3 integrin gene identified in patients with variant Glanzmann Thrombasthenia., four polymorphisms, GPIIIa, TAFI 147Ala>Thr, methylene tetrahydrofolate reductase (MTHFR) 677 C>T, and MTHFR 1298 A>C, showed significant association with Asian-Indian stroke patients below 15 years of age, ITGA2 807C>T polymorphism may be associated with reduced colorectal cancer risk., Mutation of the clasp region of alphav or beta3 results in a constitutively activated integrin, confirming the role of the extracellular clasp in restraining integrin activation., These results demonstrate that integrin alphavbeta3-mediated transcriptional regulation of MMP-9 and TIMP-1 is critical for suppressing the ovarian cancer cell invasion., VWF strings bind specifically to integrin alpha(v)beta(3) on human endothelial cells, alpha(IIb)beta(3) provides a constitutive presence of factor H on platelets; activation of platelets increases platelet-bound factor which perhaps involves other binding sites for factor H on platelets., Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions., The genetic polymorphism glycoprotein IIIa leu33pro was significantly associated with CHD., Analogous to EAE, in subjects with MS, we found increased expression of Opn in DCs and increased expression of the Opn receptors CD44, beta(3), and alpha(v) on T cells., Rationally designed integrin beta3 mutants stabilized in the high affinity conformation., M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR., HPA-1a alloantibodies have a direct effect on endothelial cell spreading and monolayer integrity., in cutaneous nodular melanomas, necrosis was associated with increased tumor thickness, tumor ulceration, vascular invasion, higher tumor proliferation and apoptotic index, increased expression of alphavbeta3 integrin & poor patient outcome, analysis of how the different antiangiogenic potential of resveratrol stereoisomers is related to their different capacity to affect alphavbeta3 integrin function, Integrin beta3, like E-cadherin, may be also a suppressor gene down-regulating invasive features of ovarian cancer cells in SKOV3 cell subclones., Ligation of alpha(IIb)beta(3) by immobilized ligands during platelet adhesion induces a transmembrane conformation change in the integrin, resulting in unclasping of the complex between the membrane-proximal parts of cytoplasmic tails., Transient expression of integrin beta(3) in SMMC-7721 resulted in an enhanced level of apoptosis and suppression of colony formation., pneumococci exploit the vitronectin-alphavbeta3-integrin complex as a cellular receptor for invasion and this integrin-mediated internalization requires the cooperation between the host signalling molecules ILK, PI3K and Akt., data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration, H. pylori ureB antibody could cross-react with human platelet GP IIIa and partly inhibit platelet aggregation. UreB may be a crucial component of H. pylori involved in the pathogenesis of a subset of ITP., Eptifibatide-dependent antibodies engage the integrin beta3 subunit so that FcgammaRIIa and its downstream signaling components become activated, resulting in thrombocytopenia and a predisposition to thrombosis., Beta3 integrin expression within uterine endometrium may have a role in unexplained infertility, Pyk2 is a critical signalling molecule downstream of beta3 integrin tyrosine phosphorylation and mediates Vav1 recruitment to accomplish actin reorganization necessary for adhesion, Data show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK, Src and VE-cadherin, increased cell permeability and decreased cell adhesion in endothelial cells., gene-expression levels of the key angiogenesis molecules VEGF and integrin beta3 were lower in neuroendocrine tumors than in colorectal liver metastases and were highly variable, These results confirm the impact of polymorphism A2 (PLA2) in platelet glycoprotein IIb/IIIa on recurrent spontaneous abortion in the period of 10 to 20 weeks of gestation., Reduced ITGB3 expression is reported in platelets hyposensitive to catecholamines when activated with TRAP., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Glycoprotein IIB/IIIA inhibitor to reduce postpercutaneous coronary intervention myonecrosis and improve coronary flow in diabetics, only indirect evidence of replication (using LD-tagging SNPs) was observed for three genes (PHF11, IL10, and ITGB3)., The structurally unique, highly conserved integrin alphaIIbbeta3 transmembrane complex rationalizes bi-directional signalling and represents the first structure of a heterodimeric TM receptor complex., HPA-3 but not HPA-1 polymorphism may be one of the inherited risk factors associated with the susceptibility of hantavirus infection and the disease severity of HFRS., Three heterozygous mutations were identified in the genes encoding platelet integrin receptor alphaIIbbeta3 in a patient with an ill defined platelet disorder, Data demonstrated significantly upregulated integrin-linked kinase as a function of alphavbeta3 in two ovarian cancer cell lines, and proved co-localization at the surface of alphavbeta3-overexpressing adherent cells., The novel autosomal dominant macrothrombocytopenia associated with platelet dysfunction raises interesting questions about the role of integrin beta(3), and its betaTD domain, in platelet formation and function., The GpIIIa A1/A2 polymorphism is not a risk factor of aneurysmal subarachnoid haemorrhage in a Polish population., The conformational dynamics of the I-like and Hybrid domains from the beta3 integrin headpiece showed that these two helices function in tandem to initiate large-scale, interdomain conformational transition apparent in integrin activation and signaling., Data show that intermediate filament recruitment to focal adhesions in endothelial cells requires beta3 integrin, plectin and the microtubule cytoskeleton, and is dependent on microtubule motors., The results suggest that Greek carriers of the HPA-1b allele with hypertension may be at increased risk for developing end-stage renal disease., These data strongly indicate that KAI1 may suppress ovarian cancer progression by inhibiting integrin alphavbeta3/vitronectin-provoked tumor cell motility and proliferation as important hallmarks of the oncogenic process., mutations in platelet GlyIIIaA1/A2 were found in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease, The regulation of EC junctional integrity involves the coordinated and dynamic modification of localization and activity of junctional stabilizers such as the integrin beta(3) and the destabilizer, JAM-C., Activating effect of PLAA1/A2 polymorphism of GPIIIa gene and 677T/T polymorphism of MTHFR gene on morphofunctional state of platelets is proved., Comparison of frequencies of genotypes of polymorphism A1/A2 of GPIIb/IIIa gene in combined sample of population and group with SCD revealed in SCD group lowering of portion of A2/A2 homozygotes, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., GPIIIa PlA2 polymorphism was frequent (27.5%), but the homozygous variant was very infrequent (0.5%). The presence of PLA2 had no influence on peri-procedural or one-year clinical outcomes., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Multiple approaches converged on the same structure of the resting integrin's transmembrane heterodimer, and this conformation likely reflects the integrin's native structure., High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism, In metastatic brain lesions carrying activated alpha(v)beta(3), VEGF expression is controlled at the post-transcriptional level and involves phosphorylation and inhibition of translational respressor 4E-binding protein (4E-BP1)., Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis., High expression of integrin beta3 and OPN in ectopic endometrium of adenomyosis may cause endometriotic lesions., the SLC6A4 and ITGB3 gene interaction may have a role in autism, inhibition of integrin beta3 in radioresistant pancreatic cancer cells could enhance adenovirus-mediated gene therapy., Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3, review focuses on the structure and function of the beta3 integrins, in particular alphaIIbbeta3, with reference to other integrins where relevant.[review], Integrin beta3 interacts with Galectin-3 in regulating endometrial cell adhesion., Altogether these data suggest that integrins alpha2 and alpha v beta 3 do not play a major role in the rotavirus entry process., Emphasizing the postulated role of myeloma cells in multiple myeloma bone disease; their osteoclast-like activity is regulated, at least in vitro, by the beta(3) subunit of the integrin., Results demonstrated that the growth inhibition of HEC1A cells by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., 22 novel mutations were identified in 45 unrelated Glanzmann thrombasthenia patients. Analysis of family members showed heterozygous mutations in all families, Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, These data are the first demonstration of conformational coupling of the integrin alphaVbeta3 leg and head domains, and suggest that inside-out activation may involve conformational changes other than the postulated switch to a genu-linear state., Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, initial activation-independent platelet adhesion to VWF via GPIb is resistant to NO, however, NO inhibits GPIb-mediated activation of alpha(IIb)beta(3) and MLC leading to reduced platelet spreading and aggregation., In a Croatian population, the gene frequencies of the HPA-1 alleles are 1a-0.854 & 1b-0.146., The authors demonstrate that the F0 domain of kindlin-1 is required for the ability of kindlin-1 to support talin-induced alphaIIbbeta3 integrin activation and for the localization of kindlin-1 to focal adhesions., while a point mutation in the clasp interface modestly activates alphaIIb beta3, additional mutations in the transmembrane interface have a synergistic effect, leading to extensive integrin activation, Data show that leberagin-C can inhibit the adhesion of melanoma tumour cells on fibrinogen and fibronectin, by interfering with the function of alphavbeta3 and, to a lesser extent, with alphavbeta6 and alpha5beta1 integrins., This study shows that alpha(v)beta(3)-integrin expression on tumor cells actually slows tumor progression and acts as a tumor suppressor., Data show that under basal conditions, sphingosine kinase-1, integrin alpha(v)beta(3), and CD31 exist as a heterotrimeric complex which is required in SK-1-mediated endothelial cell survival., BCL-6-transfected breast cancer cell lines expressed significantly higher levels of CXCR4, Itgbeta-3 and FLT-1., An A-to-C SNP at Nt 487 in exon 3 (lysine-to-glutamine substitution at position 137) & a G-to-A SNP at Nt 1960 of exon 11 (glutamic acid-to-lysine substitution at position 628) were associated with neonatal alloimmune thrombocytopenia., alphav beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2, Results describe the role of the membrane distal region of human beta(3) integrin cytoplasmic tail in platelet aggregation, secretion, alpha(IIb)beta(3) activation and fibrinogen binding., The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers., suggest that a divalent metal-ion coordination was a common driving force for the formation of both SDV/alpha v beta 3 and RGD/alpha v beta 3 complexes., GPIIb/IIIa and alphavbeta3 integrins are important mediators in the pathology of cervical cancer., Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., Oxidatively modified fibrinogen showed less binding activity than native fibrinogen to GpIIb/IIIa coated micro beads and human platelets whereas slightly higher binding capacity to ADP induced stimulated platelets, Patients with VWD carrying defective alleles of ITGB3 (1565T/C) showed milder phenotypes than expected., Data suggest a role for GPIIbIIIa integrin in caspase-3 activation induced by these platelet agonists., These data provide a mechanism for enhancement of platelet activity by alpha(IIb)beta(3) inhibitors, but also reveal a potentially important signaling pathway operating from the integrin to GPVI signaling., analysis of ITGA2B and ITGB3 mRNA splicing, expression, and structure-function relationship in Glanzmann thrombasthenia, Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes., provide the first proof that talin binding is sufficient to activate and extend membrane-embedded integrin alphaIIbbeta3, thereby resolving numerous controversies and enabling molecular analysis of reconstructed integrin signaling., study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA, the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes, Variant type Glanzmann thrombasthenia caused by homozygous p.724R>X mutation in beta3 integrin., In CAD patients receiving daily low dose of aspirin, there is a significant and independent association between the expression of GPIIIa PlA1 allele and the occurrence of persistent platelet hyperactivity detected with PFA-100, Here, the authors determined that pathogenic hantaviruses bind to quiescent platelets via a beta(3) integrin-dependent mechanism., The ITGB3 Leu33Pro amino acid substitution seems to be unrelated to the development of oxaliplatin-induced peripheral neuropathy, but it appears to be related to its severity., results presented here strongly suggest that MMP-2 interacts with alpha(IIb)beta(3) to regulate the shedding of CD40L exposed on the surfaces of activated human platelets, Results proved the importance of VEGF and integrin alphavbeta3 in the pathogenesis of AML., the interaction between Trp110 of alphaIIb and Arg261 of beta3 is critical for alphaIIbbeta3 integrity and outside-in signaling-related functions, in the presence of alphavbeta3-integrin Rac1 is not required for tumor angiogenesis, analysis of the effect of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3, GPIIIA gene (PI a allele) polymorphism efects on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease., Study helps define the pathophysiology of two rare ITGB3 mutations giving rise to GT, and describe the first patient with a qualitative alphaIIbbeta3 deficiency with both inhibitory and partially activating amino acid substitutions on the beta3 subunit., Demonstrate associations between ischemic stroke functional outcome and 2 COX-2 variants (rs20417 and rs5275) and a GPIIIa variant (rs5918)., These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions., a mutation in alphaIIbbeta3 integrin may have a role in Glanzmann thrombasthenia [case report], the Tie2/alphavbeta3 integrin association-induced integrin internalization and degradation are mechanistic consequences of endothelial Ang-2 stimulation, Frequency of glycoprotein IIIa gene variants that cause HPA-1 genotyping discrepancies., Alpha(V)beta(6), but not alpha(V)beta(3), blocked human parechovirus 1 cellular infectivity., The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, structure and mechanism of action of seems to depend on discrete transitions and to be more tightly coupled to the local environment than previously thought, [REVIEW] structure for the IIbbeta3 cytosolic domain heterodimer as it might exist in resting IIbbeta3 and protein interactions provide a background for understanding the pathogenesis of genetic bleeding disorder, A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin alphavbeta3 but had diminished cell adhesion and spreading function in vivo., Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin alphaIIbbeta3 to fibrinogen., immunohistochemistry of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin as targets for contraceptive approaches or understanding of the pathogenesis of infertility offer little benefit compared with histological dating, We have determined crystal structures of the alpha(IIb)beta(3) headpiece in the absence of ligand, Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation., Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain., glycoprotein IIIa PlA1/PlA1 genotype carriers have a significantly increased risks of acute vascular ischemic events associated with a poor prognosis at 1 year., The alphaIIbbeta3 deficiency of the proband was caused by two compound ITGA2B mutations, which were first reported in Chinese Glanzmann thrombasthenia patients., These results demonstrate that HMGB1 blocks alpha(v)beta(3)-dependent recognition and uptake of apoptotic cells., two orthogonal events regulate integrin alphaIIbbeta3's interactions with fibrinogen, Data showed that EhPCP5 RGD motif is a ligand for alpha(V)beta(3) integrin-mediated adhesion on colonic cells and represents a novel mechanism to trigger an inflammatory response in the pathogenesis of intestinal amebiasis., genetic polymorphism is associated with an increased risk of cardiovascular adverse events, TNF-alpha enhances the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the MEK/ERK/NF-kappaB signal transduction pathway., Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design., Leptin stimulates the migration of human prostate cancer cells via transcriptional up-regulation of alphavbeta3 integrin expression., our results collectively support the hypothesis that alphavbeta3 integrin has dual actions depending on the cell environment, and provide additional evidence on the role of integrins in pancreatic cancer, findings indicate that Glycoprotein IIIa leu33pro polymorphism is associated with early, spontaneous miscarriage., Data suggest that the GPIIIa and FcgammaRIIa platelet receptor polymorphisms do not influence S. aureus-platelet interactions in vitro or the clinical course of infective endocarditis., Streptococcus gordonii binding to the alpha(IIb)beta(3)/FcgammaRIIa integrin/ITAM signaling complex results in platelet activation that likely contributes to the thrombotic complications of infective endocarditis., Expression of integrin beta3 and its ligand tenascin-3 decrease the expression of uPA through p38MaPK in breast neoplasms., There was a significant association between a common ITGB3 haplotype and autism spectrum disorder., Role of integrin beta 3 polymorphisms in embryo implantation and placentation., case report of anterior ischemic neuropathy in Crohn's disease with homozygous C677T genetic polymorphism and GPIIIa variant, When polymorphonuclear leukocytes are recruited to tumor cells in a tumor microenvironment, alphaVbeta3 and intercellular adhesion molecule (ICAM)-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circulation., Data show that the alphaIIb cytoplasmic domain is largely disordered, but it interacts with and influences the conformation of the beta3 cytoplasmic domain., ITGB3 is known to be expressed on the surface of astrocyte cells in the brain. It has been shown to play a role in various developmental processes, These data provide important quantitative and qualitative characteristics of alphaIIbbeta3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow., The ITGB3 1565T/C polymorphism was found to be negatively, associated with RPL., the role of acidic extracellular pH in regulating activation of integrin alpha(v)beta(3)., kindlin-2 promotes integrin b1 and b3 activation., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., Suggest that individuals with Leu33Pro polymorphism of the GPIIIa glycoprotein may be predisposed to increased risk of atherosclerotic plaque rupture., Single nucleotide polymorphisms of integrin beta-3 gene is not associated with colorectal cancer., GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role., TLR2/+596 genotype may influence the association between ITGB3 single nucleotide polymrophisms and mold sensitization in adults with asthma., IL-8 increases integrin beta 3 expression and cell motility in human chondrosarcoma cells, these studies suggest that ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer., alpha(v)beta(3) integrin has dual actions depending on the cell environment., A vicinal thiol-containing population of alphaIIbbeta3 provides redox sensitive sites for regulation of alphaIIbbeta3., Only the threonine 410 gets dephosphorylated, possibly in an integrin aIIbb3-dependent manner, beta3-integrin has an essential effect on tumor cell proliferation and progression, and may be a potential therapeutic target for the prevention of skeletal metastases of lung cancer., analysis of alpha(nu)beta(3) integrin expression by (64)Cu- and (68)Ga-labeled RGD conjugates, The PlA1/A2 polymorphism of the GpIIIa gene was associated with deep vein thrombosis in our Italian Behcet disease patients, but does not seem to increase the risk of DVT due to factor V Leiden or prothrombin gene G20210A mutations., Intact alphaIIbbeta3 integrin is extended after activation, We now look at the repertoire of ITGA2B and ITGB3 gene defects, reexamine the relationship between phenotype and genotype, and review integrin structure in the many variant forms., BMP-7 may exert anti-invasive actions by inhibiting TGF-beta-induced expression of integrin beta(3)., designed mutations at interface between alphaIIb-subunit thigh domain and beta3-subunit I-EGF2 domain to determine effect of this interface during integrin inside-out activation and outside-in signaling, alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Direct intracoronary bolus injection resulted in a more pronounced local inhibition of platelet function and a higher degree of GP IIb/IIIa receptor occupancy as compared to standard intravenous bolus injection., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., This case-control study identified 3 genes (CYP2C19, ABCB1, and ITGB3) and 2 clopidogrel-related factors (loading dose and proton pump inhibitors) that were independently associated with early stent thrombosis, we show that while wild-type kindlin-2 is capable of promoting integrin alpha2b/beta3 activation, Integrin-alphavbeta3 was upregulated on various therapy-resistant tumor cells through chronic activation of ATM/Chk2-and NFkappaB-mediated pathways, study here indicated that integrin alphaVbeta3 had lower affinity when the ADMIDAS was mutated, Studies indicate that mutations increase the activation state of alphaIIbbeta3 and interfere with megakaryocytopoiesis., the point mutation in the EGF-4 domain of beta(3) integrin is responsible for the formation of the Sec(a) platelet alloantigen and affects receptor function, Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., A mutation in the beta3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of alphaIIb beta3 to an active state., alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1., MIF enhanced the migration of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the PI3K/Akt/NF-kappaB signal transduction pathway., KSHV induction of integrin beta3 is likely to be important for Kaposi's Sarcoma tumor formation, Recurrent mutations of ITGB3 is associated with Glanzmann thrombasthenia., Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age., Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa., Disulfide bonds in EGF domains of beta3 affect structure and function of alphaIIbbeta3 and alphavbeta3 integrins in different manner., signalling through increased NEDD9 levels requires integrin beta3 signalling, which leads to elevated phosphorylation of integrin beta3, Hantaan virus infection upregulated the expression of integrin beta3 and VEGFR2., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, In patients with DES, who require cessation of clopidogrel before surgery, bridging with GP IIb/IIIa inhibitors appears effective in preventing adverse cardiac outcomes but may be associated with bleeding in patients undergoing cardiac surgery., The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes., identified alphaIIbbeta3 integrin as a functional galectin-1 receptor in platelets, kindlins do not promote initial talin recruitment to alphaIIbbeta3, suggesting that they co-activate integrin through a mechanism independent of recruitment, describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, the role of gene polymorphism in both the thrombotic and fibrinolytic pathways in young Mexican individuals with STEAMI and suggest a synergistic effect between PIA2 and 4G allele., Disease duration of atopic myelitis is reflected in significantly higher GP IIb/IIIa values than in controls and involves the sensory system, with increased platelet aggregative function., Low concentration sclerosants activated platelets and released microparticles but inhibited platelet aggregation due to suppression of GPIIb/IIIa activation., results suggest that in some focal segmental glomerulosclerosis patients, disruption of the podocyte cytoskeleton and beta3 integrin-mediated podocyte attachment are driven by the TNFalpha pathway., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, We propose a new inside-out activation mechanism for integrin alpha(IIb)beta(3) and by inference, all of the integrins in their native cellular environment., The talin binding to the integrin beta3 transmembrane domain(TMD) alters the topology of the TMD, resulting in integrin activation., Loss of Integrin alphaIIbbeta3 is associated with Glanzmann's thrombasthenia., Expression of ITGB3 and leukemia inhibitory factor (LIF) in the peri-implantation endometrium does not change in women with unexplained recurrent pregnancy loss., These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality., study found in Mexican mestizo patients, the platelet GP IIIa PL(A1/A2) gene polymorphism does not lead to the sticky platelet syndrome phenotype, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., A similar genotype prevalence of ITGB3 was found in idiopathic sudden sensorineural hearing loss patients and controls. The PLA1/A2 polymorphism was also not associated with recovery., The findings confirm previous reports that low-avidity HPA-1a antibodies can cause neonatal alloimmune thrombocytopenia but show that the presence of such an antibody does not predict that an infant will be affected., thioridazine regulates endothelial cell functions that are relevant to angiogenesis through the suppression of the alphavbeta3/FAK/mTOR signaling pathway, Agonist stimulation, talin-1, and kindlin-3 are crucial for alpha(IIb)beta(3) activation in a human megakaryoblastic cell line, CMK., Overexpression of osteopontin, alphavbeta3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer., Contrary to suggestions from previous studies, fractalkine chemokine domain binds directly to integrins alphavbeta3 abd alpha4beta1 at a very high affinity., propose that alphavbeta3-integrin is considered a class of non-TLR pattern recognition receptors., alphavbeta3 integrin and nucleolin interact to regulate endothelial and glioma cell migration, RGD peptide plays an important role in the modulation of cell motility and in the perturbation of cell attachment affecting the malignant potential of breast cancer cells via binding to integrin alphavbeta3., The A2A2 genotype of the glycoprotein IIIa polymorphism was not associated with MI risk in Caucasians with type 2 diabetes., PPP1C isoforms have distinct contribution to the outside-in alphaIIbbeta3 signalling-dependent functions in HEK293 alphaIIbbeta3 cells., CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength, These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen., An independent impact of PL A1/A2 polymorphism on risk of stillbirth development is not be yet established but additive role of the polymorphism in combination with other thrombophilic factors should be considered., Integrins alphavbeta3 and alphavbeta5 and their ligands are expressed in distinct and heterogeneous patterns in primary and secondary central nervous system neoplasms., the PI3 kinase/Rap1 pathway is intrinsically impaired in platelets from JAK2V617F-positive essential thrombocythemia patients, resulting in diminished thrombin and thrombopoietin-mediated integrin alpha(IIb)beta(3) activation, These results suggest that alphavbeta3-IGF1 interaction, not alphavbeta3-extracellular matrix interaction, is essential for IGF signaling., Results show that mutation in integrin beta3 contributes to thrombocytopenia through gain of function mechanisms, carriage of e2/e3/e4 for polymorphism of the apoE gene, does not influence on predisposition to the longevity., The activation capacity of integrin alphaIIbbeta3 integrin was diminished in myelodysplastic syndrome platelets., The PlA2-allele of the gene encoding platelet glycoprotein-IIIa has been found to be associated with short-term cognitive dysfunction after cardiac surgery., Data indicate that EGFL7 and integrin alphavbeta3 integrin colocalized in vesicular structures in uman umbilical vein endothelial cells (HUVECs)., Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation., Results revealed that rs3809865 was significantly associated with asthma due to its effect on the binding of hsa-mir-124 to ITGB3., show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function, dRP is a novel autocrine amplifier of platelet activity, which acts on platelet redox levels and modulates integrin alphaIIbbeta3, A dual mechanism of alphaIIb-beta3 inactivation via calpain(-2) cleavage of integrin-associated proteins and via TMEM16F-dependent phospholipid scrambling with an assistant role of mPTP formation., A single disulfide bond disruption in the beta3 integrin subunit promotes thiol/disulfide exchange, in a molecular dynamics study., The study concludes that the association between PLA1/A2 polymorphism of the GPIIIa gene and the tendency to inherit migraine with aura appears significant., Integrin alphaIIbbeta3 was fully activated, independent of the morphological state of human platelets., This review focuses on the biology of integrin alphaIIbbeta3, the major membrane protein on blood platelets., results of the present study indicate likely involvement of ITGB3 and TPH2 in the pathophysiology of ASD in the Indian population., Data indicate that nuclear integrin alphav monomer in T4-exposed cells, but not integrin beta3, bound to promoters of specific genes that have important roles in cancer cells., the expression of Lewis y antigen, integrin alphav and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors., Exposure of smooth muscle cells to apo(a) in migration assays induced a potent, concentration-dependent chemorepulsion that was RhoA and integrin alphaVbeta3-dependent, but transforming growth factor beta-independent., Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction., Itgb3 is dispensable for normal hematopoiesis but is required for leukemogenesis., Review/Meta-analysis, A switchblade-like movement of the integrin leg is indispensable for the affinity regulation of alphaVbeta3 integrin., Interaction between CCL2 and CCR2 enhances migration of prostate cancer cells through an increase in alphavbeta3 integrin production, Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., Meta-analysis showed that ITGB3 SNPs are associated with age at onset in schizophrenia., study provides evidence that (99m)Tc-RGD-4CK is a promising agent for noninvasive determination of alphabeta3 integrin status and therapy monitoring in BAC, Results show a constitutive interaction between Src kinase and beta3 integrin through its SH3 domain and the phosphorylation of tyrosine in beta3 prevents this interaction., Studies indicate that Glanzmann thrombasthenia (GT) is caused by quantitative or qualitative deficiencies of alphaIIbbeta3, an integrin coded by the ITGA2B and ITGB3 genes., Spry4 overexpression resulted in decreased integrin beta3 protein levels in a post-transcriptional manner in part by modulating its tyrosine phosphorylation by c-Src. Spry4 knockdown increased integrin beta3 protein levels and tyrosine phosphorylation., ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells., Patients with the ACE DD genotype plus 1 or 2 unfavorable genotypes, the AT1R No-AA, the GPIIIa No-a1a1 or a combination of both, have twice higher the risk of MACE during their clinical follow-up., PA2 allele represents a risk factor for ST elevation myocardial infarction in young Mexican individuals but not for idiopathic ischemic stroke, ITGB3 expression is significantly lower in the endometrium of adenomyosis patients than in controls, GIC lines and their derived differentiated cultures expressed CD95 on the cell surface and were sensitive towards APO010-mediated cell death to a variable extent, Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation., HOXA10-PCAF association impairs embryo implantation by inhibiting ITGB3 protein expression in endometrial epithelial cells., These results demonstrate that serine/threonine phosphatases, probably PP2A, regulate both inside-out and outside-in mechanisms of signal transduction and clot retraction through Platelet Glycoprotein GPIIb-IIIa Complex in human platelets., Herpes simplex virus gH/gL sufficed to elicit type I IFN and NF-kappaB activation via alphavbeta3 integrin in epithelial and neuronal cell lines., Data indicate that mutations in alphaIIbbeta3 integrins decreased ligand binding and adhesion., Our data indicate an important role for the region that links the distal calf-2 and beta-tail domains to their respective transmembrane (TM) domains in transmitting the conformational changes in the TM domains associated with inside-out activation., Direct binding of Galpha13 to integrin beta3 mediates outside-in signaling and thrombus formation., these results establish that GP IIb/IIIa and alphavbeta3 integrins are essential mediators of shear flow-induced cancer cell mechanotransduction, The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.Kindlins have little direct effect on alphaIIbbeta3 integrin monomer affinity., Gene expression analysis in CHO cells reveals that the ITGB3 P189S mutation stabilizes alphavbeta3 despite preventing alphaIIbbeta3 expression., Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach., among patients undergoing elective percutaneous coronary intervention, the polymorphism Leu33Pro of platelet glycoprotein IIIa is associated with increased risk of periprocedural myocardial infarction only in diabetic patients, Swing-out of the beta3 hybrid domain is required for alphaIIbbeta3 integrin priming and normal cytoskeletal reorganization., [(18)F]Galacto-RGD PET/CT shows specific tracer accumulation in human atherosclerotic carotid plaques, which correlates with alphavbeta3 expression., PLA polymorphism of platelet integrin receptor, GpIIIa glycoprotein, (PLA polymorphism of the ITGB3 gene) is associated with the risk of myocardial infarction and CHD especially in young subjects., the study revealed no association between the risk of clopidogrel resistance and the presence of polymorphic variants of platelet receptor genes P2RY12 and GpIIIa., MiR-320a down-regulation mediates bladder carcinoma invasion by targeting ITGB3., Data indicate the role of vinculin in inducing the talin mediated integrin activation., It is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects., Among patients undergoing percutaneous coronary intervention for acute coronary syndromes, the polymorphism Leu33Pro of platelet glycoprotein IIIa is not associated with increased risk of periprocedural myocardial infarction., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding., SNP polymorphism of GP IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele)cannot be regarded as a risk factor for coronary or carotid atherosclerosis., Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa complex transmembrane/C-terminal domains and talin-1 in cell membrane environment during platelet activation., The use of LIF in combination with alphanubeta3 integrin as biomarkers appears to be superior to integrin testing alone when evaluating endometrial receptivity, primarily because of its earlier pattern of expression during the secretory phase., genetic polymorphism of the GP IIIa gene was associated with aspirin resistance in a very elderly Chinese population, Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, Data show that chemokine domain of fractalkine (FKN-CD) can activate alphavbeta3 integrin in the absence of fractalkine receptor CX3CR1, but that this activation requires the direct binding of FKN-CD to alphavbeta3., The alphaII b tail sequences distal of GFFKR participate in talin-mediated inside-out alphaII b beta3 activation through its steric clashes with beta3 -bound talin, Intermolecular transmembrane domain interactions activate integrin alphaIIbbeta3., It plays a role in regulation of leukocyte migration to a site of inflammation., A novel soluble integrin beta 3 variant in the plasma of acute myeloid leukemia patients is described., Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells., Studies sugggest that the effect of integrin alphavbeta3 in the whole process of brain function recovery merits further study., Coimmunoprecipitation studies and proximity ligation assays indicated that integrin alphavbeta3 interacts with herpes simplex virus type 2 glycoprotein H (gH)., Data suggest that endometrial levels of ITGB3 are down-regulated in women with unexplained recurrent pregnancy loss as compared to women with normal fertility during mid-secretory phase., knockdown of miR-378a increased the expression of its target proteins, vimentin, and beta3 integrin, which accelerated fibroblast migration and differentiation in vitro and enhanced wound healing in vivo., ITGB3 is downregulated 5-fold by silencing of laeverin in trophoblasts, reducing cell migration and invasion., These findings offer an explanation for the variable occupancy of the metal ion at LIMBS in alphaVbeta3 structures in the absence of ligand and provide new insights into the mechanisms of integrin regulation., diabetic retinopathy is associated with ITGA2/ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), The data presented here appears to demonstrate an increased risk of myocardial infarction in carriers of the PlA1/A2 polymorphism of glycoprotein IIIa, with an association that becomes stronger as age decreases., The totality of published data supports the hypothesis that carriage of the PlA2 polymorphism of GPIIIa is a risk factor for ischaemic strokes, and specifically those of cardioembolic and large vessel origin, Unlike the L33P substitution, the L33V transition would not affect the structure flexibility of the beta3 knee, and consequently the functions of alplhaIIbb3, High Integrin alpha3beta1 expression is associated with bladder cancer., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, Data show that thyroid hormones induce mitogen-activated protein kinase (MAPK) via integrin alphavbeta3 in bone marrow-derived cells from multiple myeloma (MM)., Herpesvirus 8 attachment and entry are dependent on alphaVbeta3 integrin localized to specific cell surface microdomains., Studied expression heterogeneity of ITGB3 and BCL-2 in lung adenocarcinoma tissue and adenocarcinoma cell line., In human breast cancer cells, alphavbeta3 was necessary and sufficient for Slug activation, Expression of the alphavbeta 3 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases, 33Leu --> Pro substitution of GPIIIa does not influence the prevalence and extent of angiographically defined coronary artery disease in general population, although apparently playing a role among younger patients., Suggest a role for cyclin D1b as a possible mediator of alphavbeta3 transcription to promote breast tumor metastasis., Although our positive results are not definitive, they suggest small effect associations of the ITGB3 gene with both ASD diagnosis and symptoms of echolalia, The methylation levels in the promoter regions of OPN and integrin beta3 genes in the vascular smooth muscle cells of varicose veins are reduced and the protein expression of OPN and integrin beta3 are increased, compared with normal veins., Report novel ITGB3 mutations causing Glanzmann thrombasthenia., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2., Conclude that tumour, rather than stromal, beta3 expression is essential and is required early for efficient spontaneous breast cancer metastasis to bone and soft tissues., Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events., ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population., Prevalence of alleles of polymorphic variants Leu33Pro and Leu66Arg gene ITGB3 among inhabitants of Siberia.The highest frequency of abnormal PLA2 allele (22.1%) and the PLA2/PLA2 genotype (8.8%) was observed among women, who had miscarried., suggest that the OPN-integrin alphavbeta3 axis is crucial for 5-FU resistance in oral squamous cell carcinoma, Integrin 3 modulates cell migration in an MMP2-dependent manner., Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3., These data identify a role of kindlin-3 phosphorylation in integrin b3 activation and provide a basis for functional differences between kindlin-3 and the two other kindlin paralogs., Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol relative to zwitterionic lipids in a headgroup structure-dependent manner., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., polymorphisms in human ITGB3 may contribute to the differential responsiveness of select patients to SSRIs., This observation suggests partitioning of the activated fibrinogen bound alphaIIbbeta3 into cholesterol rich domains is not responsible for the integrin clustering observed., Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., Cells with beta3-betaTD_del or beta3-C560R mutations had abnormal cytoplasmic extensions on immobilized fibrinogen or Von Willebrand factor. The active conformation of alphaIIbbeta3 can induce cytoskeletal rearrangements that lead to impaired proplatelet formation., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., beta 3 -Integrin inhibits LPS-induced autophagy in cardiomyocytes., Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B) and 68 novel missense variants in integrin beta 3 (ITGB3)., these results highlight ECO/siITGB3 nanoparticles as a promising therapeutic regimen to combat Triple-negative breast cancer, These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK/Pyk2 signaling pathways., MiR-320a inhibits metastasis in salivary Adenoid cystic carcinoma by targeting ITGB3 and may serve as a therapeutic target and prognostic marker in salivary cancers., results demonstrate that beta3 integrin expression depends on the source of the fibroblast and that its expression inhibits alphaSMA expression (and thus the myofibroblast phenotype)., IL-8 activates the PI3K/Akt pathway, which in turn activates NF-kappaB, resulting in the upregulation of integrin beta3 expression and increased invasion of estrogen receptor-negative breast cancer cells., ITGB3 expression increased with matrix rigidity. Blocking Ibeta3 reduced Gli2 and PTHrP expression. Ibeta3 co-localized with TGF-beta RII on rigid but not compliant films., Integrin alphanubeta6-mediated MMP-9 secretion facilitates pericellular matrix degradation at high cell density, promoting invasive growth of colonic neoplasms., T4, but not T3, controls integrin's outside-in signaling by phosphorylating tyrosine 759 in the beta3 subunit. ERK-mediated transcription regulation of the b3 monomer is regulated by T3 and T4which are alphavbeta3-ligands driving ovarian cancer cell proliferation ., GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively)., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, Data show that immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins., Ibrutinib causes GPVI and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding., Up-regulation of integrin beta3 is associated with endometrial cancer., Activated but ligand-free integrins exist mainly in the compact conformation, whereas fibrin-bound alphaIIbbeta3 predominantly exists in a fully extended, headpiece open conformation., Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1., Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit., Our data provide evidence that ADAM23 plays a role in suppression of cancer cell progression through interaction with aVb3 integrin, and suggest that downregulation of ADAM23 in SP cells may contribute toward providing a cancer stem cell phenotype, ITGB3 c.1476G>A mutation decrease the transcription level and affect GPIIIa synthesis and CD61 antigen expression., CD61-overexpressing human umbilical cord mesenchymal stem cell, which had turned into primordial germ-like cells-like cells, could be further differentiated into male germ-like cells., Monomeric fibrin displayed a higher probability of interacting with Integrin alphaIIb beta 3 and a greater binding strength., The frequencies of the rare alleles of CCR2, ITGB3, and 3'UTR of c-fms in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH is more frequent,
OFFICIAL_GENE_SYMBOL ITGB3,
OMIM_DISEASE Bleeding disorder, platelet-type, 16, autosomal dominant, Glanzmann thrombasthenia, Myocardial infarction, susceptibility to, Purpura, posttransfusion, Thrombocytopenia, neonatal alloimmune,
SP_COMMENT disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors., function:Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., online information:The Singapore human mutation and polymorphism database, polymorphism:Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP)., polymorphism:Position 433 is associated with platelet-specific alloantigen MO. MO(-) has Pro-433 and MO(+) has Ala-433. MO(+) is involved in NAIT., polymorphism:Position 515 is associated with platelet-specific alloantigen CA/TU. CA(-)/TU(-) has Arg-515 and CA(+)/TU(+) has Gln-515. CA(+) is involved in NAIT., polymorphism:Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59., polymorphism:Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)(-) has Arg-662 and SR(A)(+) has Cys-662., PTM:Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subunit:Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat., tissue specificity:Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.,
integrin subunit beta 5(ITGB5) integrin subunit beta 5(ITGB5) Related Genes Homo sapiens
CHROMOSOME 3,
CYTOBAND 3q21.2,
ENSEMBL_GENE_ID ENSG00000082781,
GENERIF_SUMMARY Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis., identification of a new alphavbeta5 integrin-interacting motif that is highly conserved in the fas-1 domains of many proteins suggesting that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins, alphav subunit cleavage is essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration, Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor., urokinase receptor-derived SRSRY peptide regulates cross-talk between fMLP and vitronectin receptors, different beta5 integrins, integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), While tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and alphavbeta5 maintains the DC's tolerogenic profile., Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, Cell surface expression of alphavbeta5 resulted in an attenuation of alphavbeta3-mediated migration on vitronectin, Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis., Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell, human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, urokinase-derived antagonists of alphavbeta5 integrin activation inhibit migration and invasion of carcinoma cells, The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Compound 4, having the DGR retro-sequence, is a low micromolar ligand for the alphavbeta5 integrin., Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., The angiogenic effects of leptin are mediated by circulating angiogenic cells and involve src kinase dependent phosphorylation of integrin alphavbeta5., Definitive endoderm highly express the integrins alphaV and beta5, which have the ability to bind to vitronectin., Ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation., The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells., Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells., p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration, Integrin alphavbeta5 is a primary receptor for adenovirus., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5., beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection., CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway., alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells, Letter, Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis., High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer., knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors, Active MMP-2 regulates VEGF-A in melanoma cells on a transcriptional level via an integrin alphavbeta5/phosphoinositide-3-kinase-dependent pathway., Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration., Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells, These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins alphavbeta3/alphavbeta5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity., Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity., CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways., integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma, study demonstrate that binding of integrin alphavbeta5 and alpha defensin 5 have opposite effects on the elastic response of adenovirus type 35, revealing a direct link between virus-host interactions and the mechanical properties of the capsid, Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells., BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB., molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools., The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes., Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta., Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin., findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells, we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone, Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1, FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma., Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration, Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes, FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1, ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population, Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway.,
OFFICIAL_GENE_SYMBOL ITGB5,
SP_COMMENT function:Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 PSI domain., similarity:Contains 1 VWFA domain., subunit:Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.,
syndecan 1(SDC1) syndecan 1(SDC1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2p24.1,
ENSEMBL_GENE_ID ENSG00000115884,
GENERIF_SUMMARY The loss of syndecan-1 expression evident in acantholytic conditions, mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma, Serum levels of soluble syndecan-1 correlated with tumor mass in patients with multiple myeloma., Soluble syndecan-1 promotes growth and dissemination of transplanted human myeloma tumors in vivo in SCID mice implanted with human bones., review of structure, function, cell and tissue distribution, regulation of expression in isoform specific manner by farnesoid X receptor, Cells adherent via syndecan-1 do not spread, but can be induced to spread by Mn(2+), suggesting that activation of a beta(1) or beta(3) integrin partner is required., TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression, High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype, shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration, The increased stromal syndecan-1 expression, coupled with its loss from the surface of carcinoma cells, may contribute to tumor cell invasion and the development of metastases, results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1, the extracellular domain mediates an interaction that is necessary for dynamic cytoskeletal rearrangements whereas an interaction of the transmembrane domain is required for the initial spreading response, results demonstrate that cell-surface syndecan-1 is a degradative target of heparanase (HPSE-1), and syndecan-1 regulates HPSE-1 biological activity, serves as a primary human papillomavirus receptor protein in natural HPV11 infection of keratinocytes., MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface, Growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1., Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases., in hyperinflammatory lesions, ephrinB2 was predominantly expressed in macrophage-like cells and EphB4 in small venules; syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells after stimulation with preclustered ephrinB2, syndecan-1 and glypican-1 have roles in progression of ovarian cancer, Altered matrix-dependent signaling due to increased levels of cell surface syndecan-1 may lead to epithelial cell invasion during early stages of tumorigenesis., Concomitant expression of syndecan-1 in both epithelium and stroma may be a predictor of unfavourable prognosis in breast cancer, and in contrast with previous studies, loss of epithelial syndecan-1 was associated with a more favourable prognosis, syndecan-1 is likely to be a critical regulator of many cellular behaviors that depend on activated alpha(v)beta(3) integrins, constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis lipopolysaccharide, osteoprotegerin affects monocyte mi-gration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1., syndecan-1 has a role in progression of invasive breast carcinomas through the remodeling of breast cancer tissue via interaction with other extracellular matrix components, Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC., Stromal syndecan-1 expression is an independent prognostic marker in pancreatic cancer, whereas epithelial syndecan-1 expression predicts better prognosis only in resectable disease., Loss of syndecan-1 plays a role in the growth of G-type cancers of differentiated type gastric cancers at an early stage, Low epithelial syndecan-1 expression was associated with a higher histological grade and a more advanced clinical stage of the colorectal cancer, Malignant glioma cells express all types of syndecans. NF-kappaB participates in the upregulation of the syndecan-1 expression at the transcriptional level, and increased expression of syndecan-1 could associate with thrombospondin-1., stromal fibroblast-derived Sdc1 stimulates breast carcinoma growth and angiogenesis in vivo, shed syndecan-1 or MMP7-syndecan-1 complexes may have roles in tumor progression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, The ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity., Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage immunoproliferative small intestinal disease (IPSID)., CD138 may have a role in progression of nodal diffuse large B cell lymphoma, syndecan-1 may have a role in progression of B-cell chronic lymphocytic leukemia, increase of Syndecan-1 in all tissue compartments and a redistribution from epithelium to stroma may be a characteristic feature for dense breast tissue, syndecan-1 shedding may modulate the pathogenesis of specific microbes, the endocytic path taken by Syn-1 is clathrin-independent and relies upon lipid raft function, Lacritin targets the deglycanated core protein of SDC1 and not HS chains or SDC2 or SDC4. Binding requires partial or complete removal of HS chains by endogenous HPSE. This limits lacritin activity to HPSE release sites as an HPSE 'off/on switch'., Syndecan-1 expression is uniquely influenced by changes in the phase and magnitude of the local stress field., domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility, Heparanase influences expression and shedding of syndecan-1, In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas., Decreased syndecan-1 is asociated with thyroid cancer, upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability, SDC1 interaction with the LG4/5 domain in kalinin is essential for keratinocyte migration., syndecan-1 regulates keratinocyte proliferation differently during skin development and in healing wounds., Results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix., heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal epithelial barrier function., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., aberrant skin expression may be involved in the development of psoriasis, n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate SDC1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect., In vitro reconstructed normal human epidermis expresses differentiation-related proteoglycans (CD44, syndecan-1, desmosealin, and 7C1)., syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma, loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas, Our findings thus suggest that a previously unknown link between integrin alpha2beta1 and syndecan-1 is important in regulating cell adhesion to collagen and in triggering integrin downstream signalling., CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C., Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms., Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma., Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation., syndecan-1 directly contributes to the growth and invasive ability of oral cancer cells, Plasma levels of syndecan-1 increased significantly during coronary artery bypass grafting, with or without the use of cardiopulmonary bypass., Oxidative shedding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that may contribute to pulmonary fibrosis., Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies., Data show that syntenin-1 binds to syndecan-1 and participates in the formation of membrane protrusions, and that syntenin-1 recruitment depends on the dephosphorylation of Tyr-309 located within syndecan-1 PDZ binding domain EFYA., Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Results show that heparanase alters the level of nuclear syndecan-1., The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in ameloblastic carcinomas is in accordance with its higher aggressiveness as compared to the rare desmoplastic and peripheral ameloblastomas., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., syndecan-1 is a co-receptor for APRIL and TACI at the cell surface of MMC, promoting the activation of an APRIL/TACI pathway that induces survival and proliferation in multiple myeloma cells, Results showed that epithelial syndecan-1 expression is reduced as lip carcinogenesis progresses (normal tissue>actinic cheilitis>lip squamous cell carinoma), suggesting that syndecan-1 could be a useful marker of malignant transformation in the lip., Ressutls show that cystic tumors of the pancreas express syndecan-1 and tenascin differently and suggest that low syndecan-1 expression might serve as a predictive factor for malignancy., the effects of syndecan-1 on myeloma survival, growth, and dissemination are due, at least in part, to its positive regulation of tumor-host interactions that generate an environment capable of sustaining robust tumor growth., Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Chronic inflammation and exogenous insulin usage increases the serum syndecan-1 level in type 2 diabetics., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., syndecan-1 might contribute to urothelial carcinoma cell survival and progression, higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus, ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., Sdc1 has a protective effect during experimental colitis., High CD138 serum levels are associated with B-chronic lymphocytic leukemia progression., Data substantiate the existence of a co-adhesion receptor system in tumor cells, whereby Sdc1 functions as a key regulator of cell motility and cell invasion by modulating RhoA and Rac activity., Age-associated study of detailed characterization of circulating CD138-negative and CD138-positive plasma cells sorted by flow cytometry shows a typical plasma cell cytology with no obvious morphological differences., all syndecans can interact with proteins of the actin-associated cytoskeleton--REVIEW, pathway driven by heparanase expression in myeloma cells, Decreased expression of Syndecan-1 mRNA and the increased expression of HPA-1 mRNA can promote the invasion and metastasis of colorectal cancer., Syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction., Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., The presence of a less mature, more resistant CD138-negative myeloma cell fraction within bone marrow microniches might contribute to high incidence of relapse of myeloma patients., Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Expression of syndecan 1 in healthy breast tissue during menstrual cycle., Results suggest a role for syndecan-1 and cathepsins D and K in growth and invasiveness of esophageal squamous cell carcinoma., This study confirms a direct relationship between suprabasal p35 localization together with down-regulation of syndecan-1 immunoexpression and dysplastic changes of oral lichen planus and hence the possibility for malignant transformation., The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma., The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., multiple regression analysis showed that apolipoprotein A1 was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes, A threshold of greater than six CD138+ metabolically active plasma cells is associated with poor kidney allograft function and survival., Loss of SDC-1 is associated with prostate cancer., couples the insulin-like growth factor-1 receptor to inside-out integrin activation, These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis, High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells., In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation. In prostate cancer samples syndecan 1 was expressed to granular-cytoplasmic localisation., sCD138 may be applicable as a surrogate marker of disease activity., A multiple regression analysis showed that BMI (beta = 0.783, P < 0.000) was a significant predictor of positive syndecan-1 neutrophils in subjects with type 2 diabetes., Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding and prevents from its subsequent induction of fibroblast proliferation., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., Syndecan-1 is up-regulated in BeWo cells during differentiation and its silencing inhibits syncytialization., CD138 may contribute to the differential diagnosis of renal tumors, syndecan-1 regulates mesenchymal tumor cell adhesion and migration, and different domains have differential effects., Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype, In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality., These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity., Syndecan-1 mediates hepatic VLDL turnover in humans as well as in mice and shedding might contribute to hypertriglyceridemia in patients with sepsis., a new role for syndecan-1 in HSV-1 pathogenesis, results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., We found increased vascular adhesion protein 1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock, Syndecan-1 expression was increased in tubular epithelial cells in allografts. Increased syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy and prolonged graft survival., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Heparan sulfate chains of syndecan-1 regulate ectodomain shedding., Our results demonstrate that syndecan plays a negative role in death receptor-mediated cell death, CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Placental syndecan-1 expression is associated with premature birth and fetal growth., syndecan-1 is a novel target of the oncomiR miR-10b., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., Data indicate that immune-magnetic CD138-positive cell sorting significantly increased the percentage of abnormal cells identified in FISH analysis of multiple myeloma (MM) samples., study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness, the increased expression of syndecan-1 at gene and protein levels is correlated with advanced tumor progression and poor outcome in patients with glioma. Syndecan-1 might serve as a potential prognosis predictor of this dismal tumor., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., observations suggest that low CD138 expression in multiple myeloma cells relates to poor prognosis, immature phenotype and low sensitivity to lenalidomide, Syndecan-1 alters the dynamic exchange of adhesion complex proteins, which in turn regulates migration speed., Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration, the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain., Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases., findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells, Data indicate that Syndecan-1 silencing had less powerful effect on the transcriptome compared to overexpression., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., The DNA methylome of CD138-positive cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanced stages of myeloma, as well as healthy controls, is characterized., SDC1 expression was not different in patients with advanced vs no/limited LBD.A significant positive correlation between gene expression & BM plasma protein levels was observed for SDC1., Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., Elevation of serum SDC1 is associated with Crohn's disease., The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating keratoacanthoma and squamous cell carcinoma, Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., SDC1 expression is associated with N stage and the status of resection margin involvement in squamous cell carcinoma (SCC) of the tonsil., High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis., Our studies demonstrates that SDC1 is the major receptor protein for HCV attachment., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, Through phenotype analysis, non-HAV-specific antibody-secreting cells are found to be Ki-67lowCD138highCD31highCD38high compared with HAV-specific ASCs., Comparative characteristics of the structure and function for syndecan-1 from animal organisms, Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data indicate that biochemical markers significantly associated with mesothelioma were hyaluronan, N-ERC/mesothelin and syndecan-1., Data indicate that the CD138int follicular B cells were clearly distinct from plasma cells., Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer., Chemotherapy stimulates syndecan-1 shedding, placental expression decreased in pre-eclampsia, independent of labor, gestational age, birthweight centile, SD1 mRNA levels do not differ between resected colon samples of patients with acute colonic diverticulites and ileocolonic Crohn's disease., Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells., Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways, It is concluded that increased SNAIL levels in advanced PC are associated with low expression of syndecan 1, Urinary levels and cellular localization of syndecan-1 are associated with differentiation status of patients with bladder cancer., Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells., Presence of SDC1 in tumor stroma is an independent risk factor for patient survival in bladder cancer, this study revealed a link between miRNA-143 and Syn-1 in the pathogenesis of melanoma., Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection., Expression decreased with the decreasing grades of dysplasia. Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., HO-1, S100A4, and SYND1 expressions have prognostic value in primary non-muscle-invasive bladder cancer (NMIBC)., Syndecan 1 mRNA expression did not vary between chronic diverticulitis and Crohn's disease., In DCIS of different nuclear grades, tissue localization of syndecan-1 is significantly divergent, suggesting a specific effect on biology and progression of DCIS., Increased syndecan-1 expression levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis of malignant gastric cardiac adenocarcinoma., Elevated levels of soluble CD138/Sdc-1 in older bladder cancer patients and those with muscular invasion sheds some light on the mechanisms of the disease invasion., Syndecan-1 is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts., syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma., syndecan-1(+) cell syncytia and excess GAG production recapitulate elements of the invertebrate encapsulation reaction, itself dependent on insect transglutaminase and glutaminated early response proteins, Sdc1 is required for HER2-mediated activation of the alpha6beta4 integrin in wound healing assays or tumor cell survival., PKC-mediated syndecan-1 downregulation causes loss of cell invasiveness in melanoma cells under anchorage independency, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., syndecan-1 may have a role as a biological and prognostic marker in patients with triple-positive breast carcinomas, The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes, High Syndecan-1 expression is associated with chemotherapy resistance in colorectal cancer., High expression of SDC1 is associated with dedifferentiated liposarcoma tumorigenesis., Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM., A significant association between SDC1 and breast cancer was identified., this work has broad implications beyond myeloma because shed syndecan-1 is present in high levels in many tumor types as well as in other disease states., Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer, Serum SDC-1 levels are increased in systemic lupus erythematosus patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN., Syndecan-1 expression is associated with tumor size and EGFR expression in colorectal carcinoma, This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation., our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans, syndecan-1 has a role in glycocalyx shedding and is increased in patients with end-stage liver disease; ischemia-reperfusion injury during OLT further exacerbates glycocalyx shedding, Sdc-1 may act as a modulator of ESC apoptosis and probably invasion depth as a crucial factor for successful pregnancy., The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality., Elevated plasma syndecan-1 levels in renal transplantation patients might be interpreted as repair/survival factor related to loss of tubular and endothelial function in transplanted kidneys., Despite presence of the HPV-receptor syndecan-1 in tongue squamous cell carcinoma (TSCC), HPV prefers the tonsillar environment., miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1., SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma., HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts., stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma, miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation., The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients., Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis., The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment., The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.,
SP_COMMENT function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix., similarity:Belongs to the syndecan proteoglycan family., subunit:Interacts with CDCP1.,