Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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A-Raf proto-oncogene, serine/threonine kinase(ARAF) A-Raf proto-oncogene, serine/threonine kinase(ARAF) Related Genes Homo sapiens
CYTOBAND Xp11.4-p11.2,
GENERIF_SUMMARY In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf., A-Raf kinase is negatively regulated by trihydrophobin 1, mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma, A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids., These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions., Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites., hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription., study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK pathway in cells treated with RAF inhibitors; ARAF seems to stabilize BRAF, Ras pathway activation via EGF treatment induced strong binding between B-Raf and C-Raf and a low level of binding between B-Raf and A-Raf., show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 signals in vertebrate embryos by directly inhibiting Smad2 signalling, Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc., The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis., Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration., analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma, Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC., This review discusses the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. [review], A-Raf interacts with MEK1 and activates MEK1 by phosphorylation.,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Binds 2 zinc ions per subunit., function:Involved in the transduction of mitogenic signals from the cell membrane to the nucleus., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily., similarity:Contains 1 phorbol-ester/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., similarity:Contains 1 RBD (Ras-binding) domain., subunit:Interacts with TH1L/NELFD., tissue specificity:Predominantly in urogenital tissues.,