Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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fibroblast growth factor 2(FGF2) fibroblast growth factor 2(FGF2) Related Genes Homo sapiens
CHROMOSOME 4,
CYTOBAND 4q26-q27,
ENSEMBL_GENE_ID ENSG00000138685,
GENERIF_SUMMARY Significant association with poor survival by bFGF., Snake venom disintegrin significantly suppresses basic fibroblast growth factor-induced human umbilical vein endothelial cell proliferation, but has little effect on normal growth of the cell., Expression of basic fibroblast growth factor (bFGF) was significantly associated with increased microvessel density in cutaneous melanomas, b-FGF serum levels were significantly higher in patients with chronic myeloproliferative disorders., bFGF up-regulated UPA in both normal and dystrophic myoblasts., Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells, Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway, HTLV-I-transformed T cells, but not HTLV-I-negative CD4(+) T cells, secrete biologically active forms of VEGF and bFGF and induce angiogenesis in vitro., stress-induced release from endothelial cells mediated by integrin alpha v beta 3, plasma basic fibroblast growth factor may have a role in progression of multiple myleoma, level spontaneously secreted by patient CLL B-cells quantified; consistently secreted in all patient samples., REVIEW, FGF2 binds to heparin-derived oligosaccharides and stimulates phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts., Basic fibroblast growth factor may control proteolysis and fibrinolysis in vessel walls by inducing plasminogen activator inhibitor-1 expression in vascular endothelium., possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts, role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction, Biological activity of substrate-bound basic fibroblast growth factor (FGF2), FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway., bFGF and aFGF may suppress endothelial-dependent monocyte recruitment and thus have an anti-inflammatory action during angiogenesis in chronic inflammation but inhibit the immunoinflammatory tumor defense mechanism, Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis., expression associated with poor outcome in non-Hodgkin lymphoma, FGF2 has a role in controlling normal and premature cranial ossification in humans [review], results show that Hensen's node and FGFs induce ectopic expression of cardiac lineage markers, and that FGF and TGFbeta family members can modulate early development of the heart, Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia., FGF-2 is a novel modulator of Lef/Tcf-beta-catenin signaling in endothelial cells, BFGF may sensitively regulate local bone resorption and remodeling through direct and indirect mechanisms that promote angiogenesis and OC recruitment, formation, differentiation, and activated bone pit resorption., This protein has a modulating control of the differentiation of human osteosarcoma cells., Data show that FGF/FGFR signaling stimulates the DNA-binding and transcriptional activities of Runx2 as well as its expression, and these are largely regulated by the PKC pathway., FGF2 and VEGF release by platelets support cell survival and cell growth of vascular endothelium cells in coculture., FGF2 is inhibited by glypican 3 in hepatocellular carcinoma cells, EphA2 does not inhibit endothelial cell survival, migration, sprouting, and corneal angiogenesis induced by this protein., The determination of bFGF will be helpful in estimating the size of infarct lesion at acute stage of cerebral infarction., Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma, bFGF has a stimulating role in lymphangiogenesis, umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass, Fibroblast growth factor-2-induced signaling is mediated through lipid raft-associated fibroblast growth factor receptor substrate 2, IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma., VEGF, but not bFGF, was associated with higher tumor grading of NHL and high-grade transformation of low-grade lymphoma., reduction of neointimal hyperplasia was observed in autologous vein grafts treated by Sendai virus human-fibroblast growth factor 2; these grafts demonstrated significant restoration of endothelium-dependent vasorelaxation, IL-1beta, TNF-alpha, TGF-beta, and bFGF are involved in bone remodeling regulation, acting as local effectors, possibly under the control of PTH., expression system is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint, focal sequences of cell surface heparin/heparan sulphate-like glycosaminoglycans from smooth muscle cells and bovine aortic endothelial cells govern, at least in part, the differential activity of FGF2 on these two cell types, FGF-2, but not VEGF, upregulated the mRNA levels for hTERT and for the hTERT gene transactivation factor Sp1. This restores telomerase activity and maintains the replicative capacity of endothelial cells., FGF-2 was expressed in most human leukemia and lymphoma cell lines tested, but only a small amount was released into the media. It may play a role in apoptosis regulation and pathogenesis., pituitary tumor transforming gene and fibroblast growth factor-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer, TSH stimulates FGFR1 but not FGF-2 expression and PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators so increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis., Alpha-2 macroglobulin and this protein interact at specific binding sites, involving different FGF-2 sequences., pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates, FGF2-stimulated cranial suture closure requires the Erk pathway and activator protein 1, FGF-2-overexpressing melanocytes exhibited marked proliferation, upwards migration, cluster formation and type IV collagen expression within the epidermal compartment, simulating early radial growth phase melanoma, Serum levels of both bFGF and TGF-beta1 were found to be significantly higher in chronic lymphocytic leukemia. Significantly higher in patients with progressive disease., The determination of the FGF-2 5'-ATR RNA secondary structure by enzymatic and chemical probing experiments showed that the FGF-2 IRES contained two stem-loop regions and a G quartet motif that constitute novel structural determinants of IRES function., plasmic degradation of fibrinogen modulates the activity and binding of FGF-2 that involves a site near the carboxyl terminus of the gamma chain, when FGF-2 was incorporated into fibrin, vascular endothelial cell proliferation was increased 6.5 -fold, equal to growth on a fibrin surface with FGF-2 continually present in the medium, role of Egr-1 (early growth response-1)in FGF-2 dependent neovascularization, tumor angiogenesis and tumor growth, FGF-2 clearly enhances cell survival of corneal endothelium after storage at 4 degrees C. Potential future application of FGF-2 as adjuvant to corneal preservation media in order to better maintain endothelial viability during corneal storage., Addition of serum to serum-starved cells rapidly induced intracellular FGF-2 clustering under the plasma membrane and into granules that colocalized with patches of the cell membrane with typical features of shed vesicle membranes., 5 residues (Phe95, Ser100, Asn102, Arg107, and Arg109) from FGF-2 into the corresponding sites in the third cassette of FGF-1 imparted high-affinity binding with dissociation constants (Kd) of 5.3 nM and 8.6 nM, compared to 1.3 nM for wild-type FGF-2., Plasma VEGF and bFGF are elevated in patients with liver cirrhosis depending on age and are predictors of outcome., bFGF adds trabecular bone mass through increasing trabecular number and trabecular connectivity., Data repropose bFGF as a noninvasive diagnostic tool for breast cancer., Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis., increased fibroblast growth factor-2 expression and decreased stromal cell compartment turnover in the diabetic placenta might be a compensatory mechanism in response to the altered physiologic milieu of maternal diabetes on placental function, Recombinant human IGF-2 and IGF-1 synergistically increase the numbers of rat oligodendrocyte progenitor cells recruited into S phase; FGF-2 decreases the levels of cdk inhibitor p27(Kip1) associated with cyclin E-cyclin dependent kinase 2., Fibroblast growth factor (FGF) 2 dramatically enhances the association of FGF receptor (FGFR) 1 with heparin and leads to proposal of a model for the stepwise assembly of a ternary FGF-FGFR-heparan sulfate proteoglycan complex on the plasma membrane., The proangiogenic action of thyroxine is MAPK dependent and mediated by FGF2., Decreased levels of bfgf in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma, lamellipodial protrusion in smooth muscle cells can be regulated by waves of Rac1 activation, corresponding to the sequential presentation of FGF-2 and remodeled collagen., Pulsed electromagnetic field augment angiogenesis primarily by stimulating endothelial transcription and release of FGF-2, inducing paracrine and autocrine changes in the surrounding tissue., Results confirmed basic fibroblast growth factor (bFGF) expression in human adult ovarian cortex, and in the isolated follicles a down-regulation of bFGF mRNA was evident as small follicles develop., upregulation of telomerase activity by FGF-2 plays a functional role in preventing the early onset of senescence, A bipartite nuclear localization signal (NLS) was uncovered near the C-terminus of FGF2. The NLS also contains signals controlling the nucleolar localization of FGF2., These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells., This study demonstrates that Chlamydia pneumoniae activates endothelial cells to produce bFGF, a growth factor which is linked to the development of atherosclerotic plaques., fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1., No significantly elevated bFGF levels were found in veins draining tumours compared with arterial samples in a patient population, suggesting that serum bFGF levels might also be derived from other sources besides the tumour, fibroblast growth factor 2 signaling is regulated by IRS-4 and ShcA, Basic fibroblast growth factor has the ability to induce the trans-differentiation into hepatic lineage cells from bone marrow cells., bFGF in plasma and bone marrow stromal cells in idiopathic thrombocytopenic purpura cases are decreased, whereas the production of bFGF remains unchanged., Overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF, two major cytokines in mesangioproliferative nephritis(MN). Caveolin-1 expression vector is potential therapy for MN., HNRNPA1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA, These results provide new evidence for the possible involvement of FGF-2 in the regulation of HA production and its appreciable roles in not only homeostasis but also regeneration of periodontal tissues., chitosan could potentiate FGF-2 activity by protecting it from inactivations by the interaction between FGF-2 and chitosan molecules, The IL-6-mediated bFGF upregulation is through activation of JAK/STAT3 and PI3-Kinase/Akt pathways., The bFGF expression was evaluated in myomas obtained after surgery., bFGF is endogenously positioned to be involved in ongoing neurogenesis in the adult hippocampus., Data show that Npn-1 can potentiate the growth-stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins., opposite effects of Noggin and bFGF for the neural tube development, PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells, A role for FGF2 in cell survival and proliferation of lymphoid and myeloid tumor cells., estrogen-dependent vascular endothelial growth factor (VEGF), especially VEGF165, and basic fibroblast growth factor(bFGF) might work on growth via angiogenesis in the human placenta throughout all trimesters of gestation, Authors show that recombinant human FGF-2 alters osteoblastic expression of bone morphogenetic protein-2 and Msx-2 in vitro to favor cellular differentiation and osteoinduction., essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1., bFGF, but not VEGF, may havea role in systemic hypoxia and anemia in solid tumor patients, analysis of complexes of FGF-2 and regioselectively desulfated heparin in aqueous solutions, Pituitary tumor-transforming gene-1 is up-regulated in human uterine leiomyomas and that the positive feedback loop between PTTG-1 and basic fibroblast growth factor may be pivotal in the growth of leiomyoma cells., Recombinant human FGF-2 signaling enhances the intrinsic osteogenic potential by selectively expanding committed chick embryo osteogenic cell populations as well as inversely regulating bone morphogenetic protein 2 (BMP-2) and noggin gene expression., combination of noggin and basic fibroblast growth factor was sufficient to maintain the prolonged growth of human embryonic stem cells, High expression of Hsulf-1 occurs in the stromal elements as well as in the tumor cells in pancreatic cancer and interferes with heparin-binding growth factor signaling, hrbFGF significantly increased Ki-67-positive cells in colonic epithelium of normal mice and up-regulated gene expression of COX-2, TGF-beta, MUC2, ITF, and VEGF in colon. Rectal administration of bFGF might be treatment for inflammatory bowel disease., finding of FGF2 and EGR1 upregulation in endothelial cell microvascular channels within organising thrombus, Hepatocyte growth factor released FGF-2 in the matrix but did not induce FGF-2 expression in external auditory canal cholesteatoma., FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways, bFGF and GLUT1 play important roles in the carcinogenesis and progression of ovarian epithelial carcinoma., bFGF and vascular endothelial growth factor contribute to a significant proportion of the survival stimulating activity, abnormally sulfated heparan sulfate in Hurler multipotent progenitor cells perturb critical FGF-2-FGFR1-HS interactions, resulting in defective FGF-2-induced proliferation and survival of Hurler multipotent progenitor cells., bFGF was found to bind more strongly to heparin-Sepharose than endostatin, the latter, but not the former, displaced protamine from heparin in solution, which supports the notion that endostatin can compete with bFGF for binding to heparan sulfate, the MAPK and two PLC pathways are required for FGF-2 to stimulate RGC neurite extension in vitro, but the response of axons to FGF-2 applied asymmetrically to the growth cone depended only on the PLC pathways, Expression of b-FGF may be associated with promotion of angiogenesis and a good prognostic factor in squamous cell carcinoma of the esophagus., Results suggest that the release of bFGF following cell death contributes to enhanced chemosensitivity in Non-Small-Cell Lung Carcinoma (NSCLC) cell lines., Not the expression of bFGF in the primary tumour but in its invasion front reflects the aggressiveness of RCC, hereby indicating a different biological potential within both areas., TGF-beta1/bFGF and ET-1 have different roles in graft fibrosis in heart failure patients, bFGF inhibited IR-induced p53 accumulation to some extent in most of these samples and by more than 50% in seven samples from seven patients with chronic lymphocytic leukemia, Significantly higher expression of TGFbeta1 and bFGF, although lower expression of core protein on the concave side, suggesting possible etiological factor or secondary change in development of adolescent idiopathic scoliosis., Using a placental explant model in a fibrin matrix, wtFGF-2 resulted in 2.6-fold more growth over control, and FGF2 binding (to fibrin) mutants increased growth 3.3 -fold. Vessel outgrowth with a nonbinding FGF2 mutant was minimal, comparable to control., The expression of basic fibroblast growth factor (bFGF) and its receptors FGFR-2, FGFR-3, and FGFR-4 in human ovaries suggests that bFGF might have a role in early folliculogenesis., The reciprocal modulating effects of FGF2 and TGFbeta1 on each other's receptors make the GM-490 cell line a new model for investigating the relationship between these growth factors and their receptors in autocrine loops., 18-kDa FGF-2 directly regulates rRNA transcription., Fibroblast growth factor 2 (FGF2) regulates rRNA transcription, in part, by localizing to rRNA genes and directly interacting with the upstream binding factor (UBF), an architectural transcription factor, in the nucleolus., FGF-2 has a role in esophageal cancer recurrence and mortality, existence of an HIF-1alpha-bFGF amplification pathway that mediates survival and sprouting of endothelial cells under hypoxic conditions., excessive release of bFGF from the cartilage matrix during injury, with loading, or in arthritis could contribute to increased proliferation and reduced anabolic activity in articular cartilage, Adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro., MM-LDL and HDL have opposite effects on aortic SMCs, Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane, Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C., These experiments show for the first time that overexpression of basic fibroblast growth factor (bFGF) in developing rodent kidneys can induce the formation of renal cysts in vivo., could play an important role in the pathogenesis of chronic apical periodontitis and periapical cysts, Overexpression of bFGF in skin of patients with systemic sclerosis along with normal serum levels suggests that bFGF probably acts in an autocrine or paracrine manner in fibrogenesis., bFGF expression upregulates CD13 expression in human melanoma cells and results in enhanced invasive capacity and metastatic behaviour of human melanoma cells., A novel mechanotransduction model is proposed in this review that supports a key regulatory role for bFGF in articular cartilage turnover, and highlights its importance as a mechanotransducer., altered HSPGs contribute to enhanced signaling of FGF-2 via FGFR1c in gliomas with glypican-1 playing a significant role in this mitogenic pathway, Study found that a dyad symmetry element (DSE) in the fibroblast growth factor-2 gene promoter exhibited different promoter activities; in HepG2 cells it did, while in U87MG cells it did not, exhibit repressive activity., there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region, analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors, abnormal expression in cartilage of Kashin-Beck disease, VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia, BFGF Is able to increase the migratory activity of Mesenchymal Stem Cells through activation of the Akt/protein kinase B (PKB) pathway., Clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells., heparanase modifies FGF2 binding, signaling, and angiogenesis in metastatic melanoma cells, Data suggest that the relative concentrations of Anosmin-1 and FGF-2 modulate the migration of oligodendrocyte precursors during development through their interaction with FGFR1., Seminal plasma and PGE(2) can similarly activate FGF2 expression and EP2 receptor signalling in endometrial adenocarcinoma cells., Immunohistochemical expression of bFGF in tumors was confirmed by real-time polymerase chain reaction., Data suggest role for FGFF2 in ductal integrity during mammary carcinogenesis, with loss of expression corresponding to loss of ductal structure., The mRNA levels of BFGF were significantly produced by the megakaryocytes may be associated with the etiology of bone marrow fibrosis in AMM., The serum level of bFGF in patients with exacerbation of chronic cor pulmonale is significantly increased., data show that growth plate perlecan binds to FGF-2 by its heparan sulfate chains but can only deliver FGF-2 to FGF receptors when its chondroitin sulfate chains are removed, The expression of collagen type II and TGF-beta1, bFGF in adolescent idiopathic scoliosis was similar to congenital scoliosis., FGF-2 transgene plays an important role in the establishment of the proper number of dopaminergic neurons and a normal sized substantia nigra during development., The bFGF expression in the endothelial cells of juvenile nasopharyngeal angiofibroma and hemangioma was positive., Intracytoplasmic sperm injection patients with serum progesterone above 0.9 ng/ml have elevated serum concentrations of basic fibroblast growth factor., Real-Time-PCR showed that TGFbeta1 expression is auto-inductive, whereas FGF2 is auto-repressive. The bioavailability of TGFbeta1 regulated by FGF2 may represent part of a negative feedback mechanism controlling stromal growth, differentiation and ECM., Inhibition of BFGF with neutralizing antibodies reduced pro-inflammatory gene expression., role for PGF(2alpha)-FP receptor interaction in modulating FGF2 expression and signaling using an endometrial adenocarcinoma cell line, Data Show bFGF was expressed in regenerative hepatocytes, but not in fibroblasts, suggesting its role in promoting oxidative stress produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis., Chromatin compaction and cell death by high molecular weight FGF2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria., Overexpression of the 18 kDa basic fibroblast growth factor protein can promote autocrine melanoma cell growth and paracrine-driven angiogenesis., In cartilage, FGF did not significantly affect ROS levels or antioxidant enzyme activity, These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression., study of cellular mechanisms underlying Apert phenotype, by analyzing effects of FGF2 in cultures of Apert periosteal fibroblasts carrying the FGFR2 Pro253Arg mutation, FGF2 has a role in tumor angiogenesis associated with haematological malignancies [review], Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells, Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis., The expression of hTERT, maspin and bFGF correlate to each other, and associate with the malignant degree of glioma., expression not different in endometriosis, The secretion of VEGF and bFGF in myelodysplastic syndrome patients is elevated and the serum levels of VEGF and bFGF are related to the classification and prognosis in MDS., TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and is mediated in part through a TbetaRII/Smad3-dependent upregulation of FGF-2 expression and release., FGF2 may contribute to the synaptic reorganization after noise damage; it may protect and/or aid recovery of synapses after overstimulation., bFGF augments hypoxia induced VEGF release in breast cancer cells mainly through the PI3K pathway and partly depending on HIF-1 activity., FGF-2 release from the lens capsule by matrix metallopeptidase 2 is essential to lens epithelial cell viability and survival, Provide useful information for understanding mechanisms of angiogenesis induced by bFGF and important data for validating a mathematical model of angiogenesis., BFGF activates the MAPK and NFkappaB pathways that converge on ELK1 to control production of MMP13 by articular chondrocytes., bFGF may promote obviously the healing of orbital implant exposure, particularly it can be the first choice for the treatment of mild degree exposure., Fibrin gel-immobiized VEGFA and BFGF efficiently stimulate angiogenesis in the AV loop model., alpha-Tocopheryl succinate disrupts angiogenesis mediated by malignant mesothelioma cells by inhibiting FGF2 paracrine signalling, bFGF does not directly act on p38 nor on the mRNA expression levels of activin receptors but inhibit activin A activation of p38 upstream of p38 in K562 cells., Exogenous human FGF-2 increased endogenous FGF-2 promoter activity and protein levels in ovine pulmonary arterial smooth muscle cells., endogenously synthesized fibrinogen promotes the growth of lung and prostate cancer cells through interaction with FGF-2., Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2), activen A expression is induced by wounding in an FGF-2- and NF-kappaB-dependent manner, Study demonstrates that the fibroblast growth factor-2 binding site of thrombospondin-1 is located in the type III repeats., Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of proliferative diabetic retinopathy., IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis., We propose FGF-2 negative feedback as potentially important in microvascular remodelling. This is consistent with the absence of a secretory signal sequence in FGF-2, as well as canalicular fragmentation, which is unique to endothelial apoptosis., Developed a mathematical model to numerically simulate angiogenesis induced by basic fibroblast growth factor (bFGF) in the corneal pocket assay., Basic fibroblast growth factor regulates expression of heparan sulfate in human periodontal ligament ce, the involvement of FGFR-1 through FGF2 in eliciting PGE(2) angiogenic responses, The expression levels of endostatin, VEGF and FGF-2 in laryngeal squamous cell carcinoma are obviously higher than those in para-carcinoma and normal laryngeal tissues., Local controlled release of bFGF from the stent-graft significantly accelerated the proliferation of new intimal tissue between the aorta and the stent-graft and within the graft materials., REVIEW, bFGF is a mitogen for the rapidly dividing cells (olfactory neuronal precursors and olfactory ensheathing cells), and also a survival factor for both slowly and rapidly dividing cells of the olfactory mucosa., FGF2 was among the genes differentially expressed in an in vivo-in vivo comparison between unfused and prematurely fused calvarial tissue., In vitro, primary effusion lymphoma -induced angiogenesis is dependent on VEGF and VEGF receptors. However, although PEL cells produce VEGF and bFGF transcripts, they only secrete VEGF in vitro, Support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability., Our data first suggest that JNK participates in bFGF-mediated surface cadherin downregulation. Loss of surface cadherins may affect the cell-cell interaction between endothelial cells and facilitate angiogenesis., Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1, FGF-2 expression in malformations of cortical development reflects incomplete differentiation and maturation of dysplastic cells, Sox2-expressing MSCs showed consistent proliferation and osteogenic capability in culture media containing bFGF, bFGF differently changes intracellular signals in ECs depending whether it is applied under microgravity or normal gravity conditions, in angiogenesis,FGF-2(fibroblast growth factor 2)-mediated enhancement of Placental growth factor (PGF) expression was dependent on Vascular endothelial growth factor function, AT genotype of the 553 T/A polymorphism was associated with PDR in Caucasians with type 2 diabetes., potent mitogenic signaling results from heparin-mediated trans-dimerization of FGF2, consistent with the asymmetric model of ternary complex formation, bFGF immunoreactivity was found to be increased in fibroblasts and in endothelial cells in early oral submucous fibrosis cases, while the expression of bFGF in stroma increased notably in advanced fibrosis., identified activin-mediated transforming growth factor (TGF)-beta signaling, platelet-derived growth factor (PDGF) signaling and fibroblast growth factor (FGF) signaling as the key pathways involved in MSC differentiation, vascular endothelial growth factor A and fibroblast growth factor 2 have effects on chemotaxis and chemokinesis, VEGF-A and FGF-2 mRNA levels were higher in the outer definitive zone of fetal adrenal gland than in the fetal zone., a transient interaction with PI(4,5)P(2) associated with the inner leaflet of plasma membranes represents the initial step of the unconventional secretory pathway of FGF-2, Document a role for FGF-2 and PDGF-BB in the temporal regulation of coronary artery stem formation and growth of the coronary arterial tree., The findings suggest interactive and sequential roles for FGF2 and NT3 on cochlear ganglion development, beta(2)GPI inhibits VEGF and bFGF-induced proliferation, migration and papillary-like tubule formation of HUVECs, The expression of Livin was positively correlated with the expression of bFGF in laryngeal squamous cell carcinoma., bFGF has an effect on the proliferation of human adenoid cystic carcinoma ACC-2 cells, ATP-binding on fibroblast growth factor 2 partially overlaps with the heparin-binding domain, Nucleostemin expression in cardiomyocytes is induced by fibroblast growth factor-2 and accumulates in response to Pim-1 kinase activity., A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer., Results reveal that platelet-derived growth factor-B-activated fibroblasts play a key role in the recruitment/migration and differentiation of mesenchymal stem cells and implicate a bFGF- and CXCL5-dependent mechanism in mediating these effects., Measuring PDGFA, bFGF, and HIF1a expression may contribute to a better understanding of the prognosis of patients with pancreatic cancer., bFGF-eluting stents are effective for accelerating organization of the thoracic aneurysm cavity and developing neointima., The delivery of bFGF was employed to stimulate proliferation and survival of primary intestinal smooth muscle cells., FGF-2 delivery from self-assembling nanofibers facilitated islet transplantation in diabetic mice., mitogenic properties of FGF-2 were maintained when SOX9 was co-overexpressed and concomitant with an increase in the production of proteoglycans and type-II collagen, subconfluent pulmonary artery smooth muscle cells express predominantly S1P2 and S1P3 receptors; S1P1 receptor mRNA levels are significantly up-regulated following bFGF treatment, Report inhibitory effects of biodegradable gelatin hydrogel sponge impregnated with bFGF on the progression of experimental abdominal aortic aneurysms., Secreted proteoglycans directly mediate human embryonic stem cell-basic fibroblast growth factor 2 interactions critical for proliferation, bFGF can play an important role in modulating plasticity and neuronal fate of human neural stem cells, Myometrium conversion into leiomyoma and an increase in its mass is accompanied by a significant increase in aFGF gene expression., bFGF, FGFR1, and FGFR2 are frequently overexpressed in squamous cell carcinoma and adenocarcinoma of the lung and may have a role in neoplasm pathogenesis, HMW FGF-2 inhibits tumor growth in glioma cells by acting on cell-cycle progression and protein translation., TGF-beta(transforming growth factor beta1), PDGF-AB (platelet derived growth factor AB) and bFGF (basic TGF-beta, PDGF-AB and bFGF) concentrations in subacromial space were higher than in the serum, FGF-b immunoreactivity in cytotrophoblasts and capillary endothelium of chorionic villi of preeclamptic subjects increased., Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice., Differences in potency or other unknown factors contribute to whether subsets of FGF-like autoantibodies from breast cancer sera exhibit long-lasting neurotrophic and neuroprotective effects or an early neurotrophic effect followed by late neuron death., E22Q and WT peptides suppressed FGF-2 expression while E22G had barely any effect. Phosphorylation of the FGF-2 receptor, FGFR-1, and the survival signal Akt were abolished by E22Q and WT peptides, but not by E22G, FGF-2 is a new substrate of PRMT5., At the early stage of tumor growth bFGF expression play important roles in the regulation of angiogenesis, tumorigenicity and subsequent metastases of human bladder cancer., FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS., These data further suggest an integral role for visfatin-FGF-2 signaling axis in modulating endothelial angiogenesis., These findings showed that HDAC inhibition antagonized FGF2 and IL-1beta induced MMP expression in articular chondrocytes., In this review, while other cell types express basal levels of plasma cell membrane glycoprotein PC-1, FGF2 only induces PC-1 expression in osteoblast related cells., Construction and characterization of a novel superantigen fusion protein, These data suggest that APO can enhance the biosynthesis and release of FGF-2 through the activation of the MZF-1 transcription factor in striatal astrocytes., Endothelial FGF2 is overproduced in pulmonary hypertension[PH] and contributes to pulmonary hyperplasia, identifying FGF2 as a potential agents against PH. potential new treatment against, Low plasma bFGF may be a marker for the presence of anti-endothelial cell autoantibodies that may contribute to the need for laser photocoagulation treatment in adult men with advanced type 2 diabetes mellitus., a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas, NMR results identified the amino-acid residues involved in the direct interaction of CXCL4 (47-70) with FGF-2., The role of FGF2 in high glucose-altered molecular signaling in pathogenesis of diabetic renal disease was studied in renal biopsy samples and cultured fibroblasts., endogenous bFGF affects the expression of angiogenin in HeLa cells., FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells., overexpression mediated by the recombinant plasmid accelerated periodontal regeneration, High tumor cell FGF2 expression is associated with non-small cell lung cancer., knockdown of RGS14 inhibited both nerve growth factor- and basic fibrobast growth factor-mediated neuronal differentiation of PC12 cells, HDAC5 represses angiogenic genes, such as FGF2 and Slit2, which causally contribute to capillary-like sprouting of endothelial cells., High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell FGF2 production or proliferation., Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer., that FGF-2 induces differentiation of neuroblastoma cells via activation of a complex gene expression program enabling modulation of cell cycle, transcription factors, and suppression of the cancer phenotype., Stimulation of VEGF protein secretion by bFGF overexpression in human melanoma cells is regulated by activation of PI-3K and p38 MAPK., engineering neural progenitors to overexpress FGF-2 may be a suitable strategy to improve the integration of grafted neural progenitor cells with the host vasculature thereby generating neurovascular clusters with a neurogenic potential for brain repair., Data suggest the feasibility of modifying BMSC with nonviral delivery systems for bFGF expression., HGF and bFGF mRNA expression can be used as useful parameters to evaluate the prognosis of gastric cancer., FGF2 induces expression of a wide repertoire of inflammation-related genes in endothelial cells, e.g. pro-inflammatory cytokines/chemokines & their receptors, endothelial cell adhesion molecules, & prostaglandin pathway components. Review., analysis of FGF-2 stimulation of RANK ligand expression in Paget's disease of bone, this is the first study investigating the association of antidepressant response and intolerance with FGF2 variants., the novel TIMP-free MMP-9/FGF-2/FGFR-2 pathway in proMMP-9-induced angiogenesis in a mammalian setting., hypoxia induces up-regulation of VEGF (vascular endothelial growth factor) and bFGF(basic fibroblast growth factor) in Adipose-derived stem cells and enhances wound healing, Fibroblast growth factor-2 regulates the stability of nuclear bodies., NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway., endogenous bFGF may not only negatively regulate the angiogenin expression but also contribute to the overall cell proliferation in H7402 human hepatoma cells, Repeated low-dose drug administration (metronomic therapy) of ibandronate has certain anti-angiogenic properties by inhibiting the stimulatory effects of bFGF., bFGF and EGF have a role in optimizing the proliferative capacity of cryopreserved human adipose-derived stromal/stem cells, binding of anosmin-1 to FGFR1 and heparin can play a dual role in assembly and activity of the ternary FGFR1.FGF2.heparin complex., Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathway., DNA dependent protein kinase suppression with the compound NU7026 or with siRNA induced basal endothelial cell proliferation as well as enhanced FGF-2 dependent proliferation., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., caspase-mediated anoikis inhibition is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells, FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells, Suggest a broader gut endodermal patterning activity of FGF2 in embryonic stem cells that corresponds to what has previously been advocated for FGF4, implying a functional switch from FGF4 to FGF2 during evolution., Hypoxia promotes FGF2- and VEGF-stimulated cell proliferation without further activation of the PI3K/AKT1 and MEK1/2/ERK1/2 pathways, respectively., These results suggest that positive feedback regulation of bFGF and IGFs leads to proliferation of hUCB-MSCs., Polymorphisms in the promoter region of the basic fibroblast growth factor is not associated with myocardial infarction in a Slovene population with type 2 diabetes., overexpression of HMW FGF2 increases FGF23/FGFR/KLOTHO signaling to down-regulate NPT2a, causing P(i) wasting, osteomalacia, and decreased bone mineral density, The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas., The expression of OPN protein and mRNA was up-regulated by FGF-2 in A549 cells., VEGF and/or bFGF (10 ng/mL) application influenced the accumulation of proteins in supernatants more profoundly under 1 gravity than under simulated microgravity., bFGF regulates ERK oscillations in premalignant but not malignant JB6 cells, 15(S)-HETE-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2., thrombospondin-1 mimics are fibroblast growth factor-2 inhibitors, FGF2 high molecular weight (HMW) isoforms have a role in the development of cardiac ischemia-reperfusion injury, Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells, high expression of VEGF and bFGF indicate that both contribute in the angiogenesis of endometrial cancer., The increased gene expressions of bFGF, alpha-SMA and PCNA in atrium during atrial fibrillation may contribute to atrial fibrosis by promoting fibroblast proliferation., TRAIL induction involves FGF-2, Sp1-phosphorylation and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury., Data show that fibroblast growth factor-2 is regulated by an endogenous antisense RNA and by argonaute-2., Three of four angiogenic factors, VEGF, b-FGF and IGF-I, are higher concentration in human milk which collected from preterm mothers than those of terms., Increased plasma basic fibroblast growth factor immunoreactivity may be a novel risk marker for coronary heart disease occurrence in adult men with advanced type 2 diabetes mellitus., adipose tissue-derived stem cells have the capacity to differentiate into capillary structures and bFGF plays a critical role in this process., Tec kinase has a crucial role in regulating FGF2 secretion under various physiological conditions, SOCS-3 is a novel modulator of FGF-2-regulated cellular events in prostate cancer., stimulates bone sialoprotein transcription in MCF7 human breast cancer cells by targeting the AP1 and CRE2 elements in the human bone sialoprotein gene promoter, peripheral and local serum levels of bFGF in patients with hemangiomas and vascular malformations, long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2, FGF2 induction of NOS3 expression is mainly mediated by AP-1-dependent transcription involving JunB and Fra1 up-regulation via sustained ERK2/1 activation in endothelial cells, A novel NF-kappaB-mediated pathway linking bFGF with iNOS and MMP-9 expression is associated with carotid plaque vulnerability., Elevated levels of VEGF and bFGF may activate the process of neoangiogenesis, which may lead to increased perfusion and an improvement in tissue oxygenation in COPD patients, The FGF2 754C/G polymorphism is associated with a risk of developing endometriosis and adenomyosis in north Chinese women., Specific FGF-2 receptors were found in the malignant epithelial but not in the benign myo-epithelial cells of salivary gland carcinoma ex-pleomorphic adenoma, indicating a paracrine role for benign myoepithelial cell-derived FGF-2., bFGF has a role in growth of human primary prostatic stromal cells, A novel TERT-bFGF axis accelerates the inactivation of p53 and consequent increase of resistance to DNA-damage response., investigation of role of bFGF in invasiveness of ovarian cancer, Decreased expression of VEGF and bFGF can inhibit the invasion and proliferation of pancreatic cancer cells., FGF2 helps to maintain genomic integrity in stem cells by activating stress-induced DNA repair., demonstrate here that galectin-3 is a mediator of vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-mediated angiogenic response., Provide evidence of Notch1-dependent endothelial FGF-2 induction by visfatin and of Notch1 activation in visfatin-stimulated endothelial angiogenesis., There were a positive correlation between the proliferation and aggressiveness of B-cell non-Hodgkin's lymphoma as measured with Ki67 and both VEGF and b-FGF., FGF-2 activated the migration of MPDL22 cells and phosphorylation of phosphatidylinositol 3-kinase (PI3K) and akt., BFGF activates MEK/ERK cell signaling pathway and stimulates the proliferation of primordial germ cells., Authors found a linear relationship between the expression of FGF2 and the level of HMGA2 overexpression as well as the tumor size, and that stimulation of myometrial tissue by a strong inducer of HMGA2, leads to an increase of FGF2 expression., Cell-cycle analysis following siRNA-mediated knockdown of NUDT6 or FGF2 indicate that both factors are involved in control of transition through the G and G boundaries, affecting cell-cycle progression, proliferation, and apoptosis., The overexpression of bFGF and underexpression of PTEN are closely related to the invasion and growth of cervical carcinoma., FGF2 overproduction contributes in an autocrine manner to the altered endothelial phenotype characteristic of idiopathic pulmonary arterial hypertension., investigation of role of FGF2 secretion by vascular endothelial cells during trophoblast invasion under cell hypoxia as a model of placentation under physiological stress (a model for role of FGF2 in cellular events leading to preeclampsia), There were no significant changes in bFGF in response to high intensity exercise or high-volume training., bFGF has a role in growth and maintenance of human embryonic stem cells, Fibroblast growth factor-2 promotes mitral valve interstitial cell wound repair, at least in part, through the TGF-beta/Smad2/3 signaling pathway., Data show that HSulf-1 depletion in breast cancer cells resulted in an increased and sustained bFGF2 (basic fibroblast growth factor) signaling and promoted cell migration and invasion under hypoxic conditions., recombinant human bFGF protein induced matrix metalloproteinase-1 , plasminogen activator inhibitor-1, and cathepsin L expression in skeletal muscle cells, basic fibroblast growth factor may be involved in the mechanisms controlling dental pulp stem cell fate decisions, FGF-2 upregulation in neurons and balloon cells is an important feature common to tuberous sclerosis and focal cortical dysplasia (FCD) with balloon cells, Transmyocardial revascularization with a bFGF-incorporated degradable stent improved global left ventricular function and attenuated left ventricular remodeling., role of the NRE of HS in FGF2 signaling and favor the formation of the symmetrical architecture on short NS domains., Examines the potential of recombinant cytokines, particularly basic fibroblast growth factor (bFGF, FGF-2) to promote periodontal tissue regeneration, and discusses the present and future outlook of FGF-2 therapy in periodontal treatment [review], Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death., Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells., amitriptyline-induced FGFR activation might occur by the MMP-dependent shedding of FGFR ligands, such as FGF-2, thus resulting in GDNF production, Findings suggest that there is a cooperation mechanism between basic fibroblast growth factor and angiogenin in A375 cells, and the cooperation mechanism affects the progress of tumor cell proliferation and angiogenesis., changes in endogenous FGF-2 levels contribute to FGF-1's early adipogenic effects and highlight the complexity of the paracrine interplay between FGFs within human adipose tissue, JNK/SAPK signal pathway plays an important role in regulating bFGF-mediated angiogenesis in HUVECs, FGF signaling coordinately regulates mineralization-related genes in the osteoblast lineage and that ERK signaling is essential for Dmp1 expression and osteocyte differentiation., report demonstrates that engineered porous coral constructs using bFGF gene-transfected human BMSCs may be a feasible option for surgical transplantation in TMJ repair, The effects of the small molecular inhibitors of VEGF receptor 2 and other tyrosine kinases on pro-angiogenic responses through VEGF-A and basic fibroblast growth factor are reported., ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway., This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from Non-gastrointestinal stromal tumor soft-tissue sarcomas patients., survivin, through upregulation of VEGF and bFGF, plays an essential role during glioma angiogenesis, High BFGF is associated with colorectal cancer., The mRNA expression of VEGF and bFGF, the protein expression of VEGF, bFGF, and ES and microvessel density (MVD) are increased both in the uraemic predialysis and peritoneal dialysis patients., Endothelial caveolin-1 functions as a platform for regulating FGF2-induced angiogenesis through spatiotemporally compartmentalizing FGFR1 and the AKT1 and ERK1/2 signaling modules., Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling., FGFR1 is the major mediator with the degenerative potential in the presence of FGF-2 in human adult articular chondrocytes, Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells., FGFR3c, critical for bone development, elicit a similar response to Fgf1 and Fgf2 at low, but not at high, concentrations; results demonstrate the versatility of FGFR3c response to fgf1 and fgf2 and highlight the complexity in fgf signaling., Mean serum values of b-FGF were significantly higher in multiple myeloma compared with controls & with increasing disease stage. A complex network of cytokines induces bone marrow neovascularization in MM., The expressions of VEGF, bFGF, and BMP-2 mRNAs decline in traumatic and nontraumatic avascular necrosis of femoral head., Levels of FGF2 and FGFR1 in saliva and serum from patients with salivary gland tumors were significantly higher than those from healthy control subjects suggesting their potential use as cancer biomarkers., The extracellular matrix of benign myoepithelial cells induces the increase in fibroblast growth factor 2 expression., a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription., Chlamydia trachomatis elementary bodies bind to FGF2, which facilitates bacterial binding. FGF2 promotes internalization of EBs via FGFR. C. trachomatis stimulates FGF2 transcription, production, and release to facilitate additional rounds of infection., Rates of expression of b-FGF in osteosarcoma and osteochondroma were 76.7% and 43.3% respectively. There was no correlation between b-FGF and endostatin expression in the osteosarcoma group., The results of this study proposed that FGF-2 and Anosmin-1 are markers for the histopathological type and the level of inflammation of multiple sclerosis lesions, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., the serum VEGF and bFGF level can be used as indicators of AL efficacy, and are correlation with the prognosis of children with AL., polySia-NCAM might be involved in the regulation of FGF2-FGF receptor signaling through the direct binding of FGF2 in a manner distinct from heparan sulfate., Report increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma., Report bFGF nasal spray improves rat memory impairments induced by co-injection of beta-amyloid and ibotenic acid into the bilateral hippocampus., The combined blockade of the signaling pathways of several growth factors, including Fgf2, might be useful in controlling the aggressiveness of osteosarcoma., The results provide evidence for gene interactions among BDNF, FGF2, and VEGFA in stroke outcome, In vivo stimulation of BT-474 cell growth by progesterone is associated with down-regulation of FGF-2., Heparanase can induce angiogenesis to promote tumor growth by releasing bFGF and VEGF in nasopharyngeal angiofibroma., TSG-6 reverts the inhibitory effects exerted by PTX3 on FGF2-mediated angiogenesis through competition of FGF2/PTX3 interaction., The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased., FGF2 genetic variants are unlikely to influence susceptibility to myopia., found that increased Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin protein, the delivery to the injury region of the therapeutic genes vegf and fgf2 reduced cavitation, restrained the processes of secondary degeneration and supported the number of myelinated fibers in the injured spinal cord., Tested feasibility of using bioprinting for cartilage engineering. Bioprinted samples treated with FGF-2/TGF-beta1 had the best chondrogenic properties among all groups., FGF-2-deficient mutant superoxide dismutase (SOD)1 mice show a significant delay in disease onset and less impaired motor performance in comparison to mutant SOD1 mice with normal FGF-2 levels., FGF2 delivery to human adipose-derived stem cells transplantation sites enhances their long-term angiogenic efficacy transplanted into ischemic tissues., VEGF and bFGF may participate in the pathogenesis of inflammatory pericardial disease, Transduction with FGF-2 encoding lentiviral vectors resulted in overexpression of the respective isoform in all tested cell populations., Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion., FGF2 was found to mediate DNA repair in epidermoid carcinoma cells, The extracellular signals of NGF and bFGF induced neuron differentiation of human endometrial stem cells., Phosphate-independent effects of high-molecular weight (HMW) isoforms in vitro may be directly mediated in part via FGF23 and HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro., FGF2 was significantly higher in the metastatic vs. the non-metastatic urothelial cell carcinoma of the urinary bladder., Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor., Data suggest that FGF2 is involved in regulation of Sertoli cell function; CREB (cAMP responsive element binding protein) phosphorylation in cultured rat Sertoli cells appears to be up-regulated by human FGF2 or interleukin-1beta., An inhibition study of bFGF receptor demonstrated that the improvement of cell proliferation resulted from the role of bFGF released from the CPCs., In the tumor microenvironment, the reciprocal interplay between FGF-2 and VEGF-C collaboratively stimulated tumor growth, angiogenesis, intratumoral lymphangiogenesis, and metastasis., BFGF is upregulated in POEMS syndrome. It could not be ruled out that this increase was due to feedback of elevated VEGF levels., Fibroblast growth factor 2 stimulates FGFR-2 expression, resulting in decreased TWIST1 expression and increased Runx2, alkaline phosphastase and osteopontin expression., This work reveals an anti-angiogenic role of STAT1 activation that acts in Tie2-R849W-expressing endothelial cells to impair VEGF-A-mediated STAT3 signaling, bFGF production, and smooth muscle cell recruitment., These findings suggest human serum, FGF-2 and TGF-beta3 as possible candidates to support biological treatment strategies of AF defects., High basic fibroblast growth factor is associated with renal cell carcinoma progression., Delivery of the therapeutic genes VEGF and FGF2 to the damaged region and their expression in cell carriers stimulates vascularization and post-traumatic spinal cord regeneration., The ASM cell differentiation promoted by TGF-beta is antagonized by FGF-2., Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer., FGF2 binds to LYVE-1 with a higher affinity than any other known LYVE-1-binding molecules, such as hyaluronan or PDGF-BB. Glycosylation of LYVE-1 is important for FGF2 binding., Correlative Hsp47 expression in fibroblasts with bFGF in inflammatory cells may contribute to stromal fibrosis and obstruction in colorectal carcinoma, Expression levels of VEGF and bFGF are significantly decreased in pressure ulcer wounds at stage III-IV., FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression., Il-1beta enhances cell migration through AP-1 and NF-kappaB pathway-dependent FGF2 expression in human corneal endothelial cells., No significant relationships were observed for bFGF polymorphism and susceptibility to B cell chronic lymphocytic leukemia, a novel mechanism for hypoxia-induced FGF2 and VEGFA through HIF1alpha-mediated inhibition of miR-503, Fibroblast growth factor 2 (FGF-2) strengthens the endothelial cell blood-brain barrier function by increased occludin and ZO-1 expression., FGFR2 rs1219648 variant is more strongly associated with breast cancer risk in estrogen-only hormone users, Nck plays a pivotal role in integrating FGF-2 and endoplasmic reticulum (ER) stress signals to counteract the ER stress deleterious effect on cancer cell survival., studied the functional consequences of HSulf-2 activity on fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities, high expression in uterine leiomyoma, correlated with T-cadherin, results indicate that FGF2 increases BSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human BSP gene., FGF2 -FGFR1 activation through an autocrine loop is a novel mechanism of acquired resistance to EGFR-tyrosine kinase inhibitors., The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients., Up-regulated cten modulates cell migration induced by FGF2., A novel role for FGF2 in regulating PDGFRA expression in a subset of gliomas with younger age at disease onset and longer patient survival regardless of the morphological diagnosis., These findings indicate that bFGF could rapidly activate the protein kinase B activities, enhance the expression of survivin and the proliferation of hepatocellular carcinoma cells via the PI3K pathway., All stem cell lines were expanded with fibroblast growth factor-2., Tumor cell expression of FGF-2 proved to be an independent prognostic factor for LRC and OS. This factor can help personalize treatment and stratify patients in future trials., Cell population growth indices were higher for those in FGF-2 supplemented media., The biomarker profile comprised of NGAL, FGF-2, and EGF increased the specificity to detect acute kidney injury in critically ill children, Defective placental maturation is associated with an imbalance of expression of bFGF and prokineticin (PK) receptor 2., Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF., EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1., These data suggest that the upregulation of either IL-8 or bFGF is closely related to the transition from liver cirrhosis into HCC., Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data suggest that the enhanced cell growth was likely due to the electrical stimulation up-regulated secretion of FGF-1 and FGF-2., show that these classical mitogenic pathways do not mediate the cytostatic activity of FGF2, P = 0.095) and healthy individuals (0.37 versus 0.19, OR = 2.51, P = 0.038). These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL., Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia., Intrapleural administration of sustained-release basic fibroblast growth factor induced lung regeneration in rats with elastase-induced pulmonary emphysema., Mechanistic insights into the S100B-FGF2 complex interface and cell-based assay studies involving mutants led us to conclude the novel role of S100B in FGF2 mediated FGFR1 receptor inactivation., Transcriptome analysis comparing control adult human fibroblasts with FGF2-treated fibroblasts identified functional groups of genes that reflect transcriptional changes potentially contributing to their regeneration competence., expression of Mll-Ell in myeloid progenitor cells resulted in autocrine production of Fgf2 and Fgf2-dependent cytokine hypersensitivity., study has identified an upregulation of a proangiogenic signature in bevacizumab-refractory Head and Neck Squamous Cell Carcinoma tumors that converges on ERK signaling to upregulate FGF2, which then mediates evasion of anti-VEGF therapy., Metastatic melanoma patients who achieve FGF-2 suppression are more likely than those who do not to have a response or stable disease., FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels., Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma., TbetaRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TbetaRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK., bFGF mRNA is significantly overexpressed in acute colonic diverticulitis compared to ileocolonic Crohn's disease., In mesenchymal stem cells from aplastic anemia patients, FGF2 gene expression was downregulated. Within the patients' bone marrow, low FGF2 expression was validated both in mononuclear cells and in the extracellular fluid., APE1-small interfering RNA significantly inhibited tumor angiogenesis by downregulating in vitro expression of FGF2 and FGFR3., High serum FGF2 levels are associated with gastric and gastroesophageal junction cancers., FGF2 overexpression is associated with triple-negative breast cancer., elevated extracellular concentration of ONOO- produces an upregulation of the angiogenic factors VEGF, hypoxic-inducible factor-alpha (HIF-1alpha), and BFGF in a human corneal limbal epithelial (HCLE) cell line., Identification of critical factors needed for reprogramming may allow for nonviral, chemically defined derivation of human-induced multipotent cells that can be maintained by exogenous FGF2., FGF2 transcriptionally stimulated the expression of miR-149 independently of its host gene, We found that transforming growth factor-beta, in contrast to fibroblast growth factor-2 and interleukin-6, promotes human pulmonary pericyte differentiation into contractile smooth muscle-like cells., The results of bisulfite genomic DNA sequencing showed that in HCAECs treated with oxLDL, the GC-rich promoter of FGF2 was heavily methylated at cytosine residues, whereas cotreatment with anti-MDA markedly reduced oxLDL-induced FGF2 promoter methylation, Nuclear targeting of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion., The results presented here indicate that histone acetylation and additional chromatin modifiers are important in determining the relative levels of FGF2 and NUDT6., interplay between hCG and bFGF occurred by activation of the p44/42 MAPK signaling pathway, osteogenic induction by the sequential delivery of BMP-2 followed by FGF-2 from core-shell microspheres was even worse than that from microspheres loaded with BMP-2 in both core and shell, although comparable to the cases of parallel delivery of dual GFs, suggest that FGF2 inhibits osteoblast mineralization by limiting the capacity of matrix vesicles., The paracrine effect of USCs or USCs-FGF2 induced improvement of erectile function in type 2 diabetic rats by recruiting resident cells and increasing the endothelial expression and contents of smooth muscle., FGF2 enhances formation of HIF-1 nuclear complexes via ERK pathway., These data suggested that Epac1 in melanoma cells regulates melanoma progression via the HS-FGF2-mediated cell-cell communication., Overexpression of FGF-2 and SMA is associated with local recurrence and reduced recurrence-free survival after definitive CRT for esophageal squamous cell carcinoma, Serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder were significantly higher than those in healthy controls, Hi-FGF-2 represents a substantial fraction of FGF-2 in human cardiac (atrial) tissue., bFGF mRNA expression did not vary between chronic diverticulitis and Crohn's disease., MT1-MMP controls FGF-2 signaling by a proteolytic mechanism that decreases the cell's biological response to FGF-2, FGF2 acts as a protective growth factor after lung epithelial injury, and call into question the role of FGF2 as a profibrotic growth factor in vivo., ower serum FGF-2 levels contribute to the pathophysiology of major depressive disorder and that FGF-2 may be used as a peripheral biological marker, this is the first study to demonstrate that bFGF can induce EMT via AKT/GSK-3beta/Snail signaling pathway in prostate cancer cells., FGF-2 facilitated the collagen-producing potency of hBMSCs both in vitro and in vivo, rendering them more suitable for use in collagen regeneration in the clinical field., These studies demonstrate a feedback loop between Klotho depletion and FGF2 activation in renal fibrosis., miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2., High bFGF levels are associated with gynecologic cancer., hBM MSC can be coaxed to differentiate efficiently into dopaminergic neurons in the presence of a very simple media cocktail containing only one main inducer like FGF2, TSP-1 cooperates with FGF-2 and VEGF/VEGFR-1 in determining melanoma invasion and metastasis, as part of a Slug-independent motility program., we propose FGF2 to be a useful prognostic biomarker for proneural glioma patients, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., Gelatin sponges impregnated with more than 100 mug/cm(3) b-FGF incorporating beta-TCP with chondrocytes (10x10(6) cells/cm(3)) can fabricate engineered cartilage at 4 weeks after implantation., with increasing protein concentrations, FGF2 monomers make contacts with each other and form dimers or higher order oligomers. FGF2 purified with ion-exchange chromatography did not show similar perturbation indicating that self-association of FGF2, Knockdown of BAG3 also significantly suppressed motion and invasion of HK2 cells mediated by FGF-2, Alternate protein isoforms arise through the use of AUG and non-AUG (CUG) translation initiation codons., Enforced expression of FGF2 partially reversed the inhibition of cell proliferation., FGF2 overexpression is associated with aggressive pathologic features and worse outcomes after radical cystectomy for squamous cell carcinoma, Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1., The nuclear odyssey of FGF-2 is reflected by nuclear dynamics, localization to nuclear bodies such as nucleoli, binding to chromatin and engagement in various protein interactions. [review], Results support the idea that human striatal precursor cells possess the machinery for their adaptation to hypoxic conditions and that neurotrophic factors, such as FGF2 and ET-1, may sustain neurogenesis and long-term survival, Endostar might exert its anti-tumor effect via suppressing b-FGF-induced angiogenesis and b-FGF-activated MAPK signaling pathway., Report no correlation between serum FGF2 and renal parenchymal scar or grade of reflux nephropathy., JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2., bFGF promotes VEGF expression in chondrosarcoma via c-Src/p38 signal cascade, promoting endothelial progenitor cell-primed angiogenesis., Data show that, depending of its concentration, FGF2 can be either a positive or negative factor of adipogenesis by regulating the ERK signaling pathway providing a mechanistic basis for FGF2 roles in adipogenesis and development of fat tissues., The data suggest that breath condensate of patients with pulmonary hypertension is characterized by increased levels of the angiogenic factors angiogenin, VEGF and bFGF as well as TNF-alpha, but not IL-8., Data suggest that plasma levels of FGF2 are up-regulated and levels of VEGFA (vascular endothelial growth factor A) are down-regulated in type 2 diabetes mellitus (T2DM) patients with diabetic foot (DF) as compared to T2DM patients but without DF., miR-203 inhibits of renal cancer cell proliferation, migration and invasion by post-transcriptionally targeting FGF2., The FGF2-binding peptide derivative P32 has improved stability, is relatively safe, and may have therapeutic potential in FGF2-driven gastric cancer., the main physiological effect of bFGF on myoblast migration is chemokinesis; changes in the surrounding ECM, resulting from aging and/or disease may impact muscle regeneration by altering myoblast migration and proliferation, Macrophage-secreted FGF-2 suppresses M. avium proliferation through various ways including cytokine production, enhancement of phagocytosis as well as oxygen/nitrogen metabolism., This study reveals a novel role for the ERK5-MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts., Some valve interstitial cell and some valve endothelial cells expressed FGF2 in valve tissue and this expression was increased in calcified valves., FGF2 nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells, bFGF Promotes the Migration of Human Dermal Fibroblasts under Diabetic Conditions through Reactive Oxygen Species Production via the PI3K/Akt-Rac1- JNK Pathways., these multifaceted effects of FGF-2 promote new tissue formation at the early regeneration phase., FGF2, considered to be primarily catabolic in articular cartilage, is not downregulated as ARGS concentration declines over time since injury, FGF-2 affects the mRNA and protein expression of Runx2, but not the osteocalcin protein level., These studies identify nuclear bFGF as a protein in a subset of TN breast cancers that likely contributes to drug resistance following standard chemotherapy treatment., LTBP-2 is a potent inhibitor of FGF-2 that may influence FGF-2 bioactivity during wound repair particularly in fibrotic tissues., circulating FGF-2 induces intestinal hemorrhage in mice treated with pentosan polysulfate., Basic fibroblast growth factor (bFGF) recapitulated the effects of the conditioned medium in inducing re-expression of cancer stem cells markers and increasing neurosphere formation ability of differentiated glioblastoma multiforme cells, FGF2 directly affects not only the biological properties of endothelial progenitor cells but also the expression pattern and secretion of numerous chemocytokines to regulate angiogenesis., miR503 significantly decreased the migration and invasion ability of the osteosarcoma cells, which may be mediated by the inhibition of fibroblast growth factor 2., Serum CEA, SCCA and bFGF joint detection improved detection sensitivity in lung cancer and had important reference value for pathological type deduction., ASC proliferation was enhanced by hypoxia. HIF-1a activation, FGF-2 production, and the ERK1/2 and Akt pathway were involved in this regulatory mechanism., Expression of FGF-2, FGFR-2 and FGFR-3 was upregulated in patients with potentially malignant oral lesions serving as biomarkers of malignant transformation to oral squamous cell carcinoma., Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts., The present study is the first to thoroughly assess the enhancement of neural differentiation of bone marrow mesenchymal stem cells following transfection with bFGF and NGF., determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients, FGF specifies hepatic fate at least in large part by inducing expression of NKD1 to transiently suppress the canonical WNT pathway., FGF2 monoclonal antibody inhibited angiogenesis in HUVEC cell cultures., Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf., these data demonstrate that FGF-2 priming enhances the angiogenic potential of SHED through the secretion of both HGF and VEGF., BFGF overexpression is a potential indicator of worse prognosis for patients with operable non-small- and small- cell lung carcinomas. (Meta-analysis), FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity, Four FGF2 isoforms result from alternative translation initiation from an AUG and 3 non-AUG (CUG) start codons., A new FGF2 isoform results from the use of a non-AUG (CUG) translation initiation codon.,
OFFICIAL_GENE_SYMBOL FGF2,
SP_COMMENT function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors., miscellaneous:This protein binds heparin more strongly than does aFGF., PTM:Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing., sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon., similarity:Belongs to the heparin-binding growth factors family., subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2., tissue specificity:Expressed in granulosa and cumulus cells.,
fibronectin 1(FN1) fibronectin 1(FN1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q34,
ENSEMBL_GENE_ID ENSG00000115414,
GENERIF_SUMMARY Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium, We show a novel alternative pathway of apoptosis that is regulated by the alternatively spliced V region and high-affinity heparin-binding domain of fibronectin, Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride, Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading., Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus; multivariate analysis showed that plasma fibronectin levels were not an independent predictor of LV thrombus formation., Low density lipoprotein receptor-related protein (LRP) functions as a catabolic receptor for Fn, Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11)., differential role of u-PA and t-PA as inducers of fibronectin mRNA, investigation of the role of direct contact with stroma and the ECM protein fibronectin in the preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors, Adhesion of hairy cells to fibronectin inhibits interferon-alpha-induced apoptosis., fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility, Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., proximal tubular cell fibronectin production induced by oleate-complexed recombinant human serum albumin was mediated via protein kinase C activation, These data indicate that fibronectin polymerization is a critical regulator of extracellular matrix organization and stability., familial combined hyperlipidemia plasma stimulated secretion of several distinct hepatic proteins, among which fibronectin was identified, FN may be partly involved in the increase in SPARC (secreted protein, acidic and rich in cysteine) glycoprotein expression by TGF-beta 1 in human periodontal ligament (HPL) cells., REVIEW, Streptococcus pyogenes isolates were able to recruit collagen type IV via surface-bound fibronectin; fibronectin-mediated collagen recruitment represents a novel aggregation, colonization and immune evasion mechanism of S. pyogenes, FN may have a role in the pathogenesis of papillary thyroid carcinoma, all six modules of the gelatin-binding domain contribute to the interaction with gelatin either directly by contacting the ligand or indirectly through module-module interactions, differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the Sturge-Weber syndrome (sws) normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS., Fibronectin secretion by renal fibroblasts was increased upon exposure to high glucose, but with delayed kinetics compared to TGF-beta1-induced fibronectin., Pathogenic bacteria, Staphylococcus aureus and Streptococcus pyogenes, attach to human fibronectin through a tandem beta-zipper, AngRem104 is a novel human gene potentially involved in regulation of fibronectin induced by AngII in human mesangial cells., An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases., an additional marker of malignant potential of thyroid nodular lesions (oncofetal fibronectin), levels of fibronectin in the extracellular matrix are regulated by uPAR and integrin receptors, FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis., Fibronectin plus TNF-alpha stabilizes granulocyte macrophage-colony-stimulating factor (GM-CSF) mRNA, increases GM-CSF secretion, and prolongs in vitro eosinophil survival., Abundant expression of fibronectin is a major feature of leukemic dendritic cells differentiated from patients with acute myeloid leukemia, the aggrecanase activity of ADAMTS4 is inhibited by fibronectin through interaction with their C-terminal domains, crystal structure of the 2F1(3)F1 module pair, human fibronectin binding to streptococcus requires specific recognition of sequential F1 modules, Adding 110-120 kDa fibronectin fragments to normal blood replicated changes in monocyte CD49e, CD62L, CD11b, & CD86 seen in vivo in HIV-1 patients. FNf caused monocytes to release proteinase-3. Monocyte behavior in HIV-1 patients may be affected by FNf., Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., fibronectin concentration significantly elevated in ovarian cancer patients with recurrent disease compared with ovarian cancer patients without recurrence, demonstrate that integrins alpha(5)beta(1) and alpha(v)beta(3) support fibronectin-dependent platelet adhesion and the generation of filopodia but that, in contrast to the integrin alpha(IIb)beta(3), are unable to promote formation of lamellipodia, Site-directed mutagenesis of amino acids coordinating Ca2+ drastically decreased the binding of C-reactive protein to fibronectin (Fn), indicating that the Ca2+ -binding site indeed formed the Fn-binding site., Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, integrin-dependent function of the ninth and tenth FIII domains of human fibronectin depends on interdomain tilt angle, adhesion of uveal melanoma cells to the extracellular matrix proteins fibronectin, type IV collagen and laminin might confer resistance to the chemotherapeutic agent cisplatin, The heparin II domain of fibronectin mediated the incorporation of paxillin into focal adhesions., Fibronectin enhances IL-1 beta-dependent airway smooth muscle cell secretory responses through a beta 1 integrin-dependent mechanism., SGK1 activation has a role in oncofetal fibronectin expression, Fibronectin and ezrin were upregulated in primary laryngeal carcinoma., Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis., FN modulates thyroid cancer cell adhesiveness and, at least in part, mediates vitamin D actions on neoplastic cell growth., The relative amounts of the 60, 90 and 100 kDa FN fragments were 2-3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group, suggesting that seminal plasma FN fragments may contribute to fertilization., FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, Chemical shift differences between the fibronectin glycoforms have revealed an intimate interaction between one N-linked sugar and the polypeptide that is critical for gelatin binding., Over-expression of oncofetal fibronectin is associated with thyroid carcinoma, binding with C terminus of apolipoprotein [a], These results provide evidence for an additional level of control of fibronectin deposition through cell interactions with the local microenvironment., the role of the extra domain A (EDA) and type III connecting segment (IIICS) of fibronectin in fiber assembly, topographical distribution and proteolytic cleavage, Results show fibronectin plays a role in the regulation of hematopoiesis by binding to FLRG and follistatin., platelet fibronectin may have a role in progression of coronary artery disease, The expression of FN protein was higher in cortex cataract than in nuclear cataract., Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, Results indicate that the adhesion mechanism by embryonal fibronectin may be involved in human blastocyst implantation., constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP, review goes over roles of fibronectin in platelet functions with a focus on fibronectin assembly within developing platelet thrombi., Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., IL-1, FN, and FN-derivatives have interrelated roles in determining biomaterial-modulated macrophage function [review], The role of the matricryptic site of the fibronectin terminal repeat III1 in cell proliferation and growth is reported., Review highlights the role of fibronectin as a key orchestrator for the assembly of multiple extracellular matrix proteins., Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP., the FN1 alpha-helix is involved in an Ig5-FN1 interaction that is critical for the correct positioning of Ig5 N-glycans for polysialylation, analysis of L-isoaspartate formation and gain of function in fibronectin, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., Downregulated expression of migration-inducing FN-isoforms in contrast to unchanged FN receptor expression may contribute to the observed alterations of Crohn's disease colonic lamina propria fibroblasts migration., Our results indicate that Src maintains fibronectin matrix at the cell surface through its effect on integrin activity and paxillin phosphorylation., fibronectin does not have an obvious role in development or progression of coronary artery disease, epithelial fibronectin suppression is not only involved with malignancy, but can also occur with benign processes that involve leukocyte migration, local presence of endogenous Tlr4 ligand Fibronectin EDA is not associated with in an unstable plaque phenotype in humans, Interaction of fibronectin carboxy-terminal regions with the fibrin alpha C chain occurs through two types of binding sites, one with high affinity and another one with much lower affinity, both of which play a role during hemostasis and wound healing., Smad 7 transfection reduces the expression of COL1A2 mRNA and the synthesis of type I collagen, but has no effect on fibronectin mRNA expression., ED-B fibronectin expression is closely associated with inflammation in atherosclerosis., The IIICS region of FN is a novel zinc-binding module., Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production, MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the risk of lymphoma development in MCsn., TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., Fibrinogen has a role in controlling human platelet fibronectin internalization and cell-surface retention, study concludes that increased platelet fibronectin may partially contribute to platelet aggregation in patients with coronary artery disease, Expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC., These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., high molecular weight hyaluronan suppresses HBFN-f-activated NF-kappaB in rheumatoid arthritis chondrocytes, Results show that neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2)is co-expressed with migration stimulating factor (MSF or FN1) by keratinocytes and acts as a functional inhibitor of MSF., expression of the alternatively spliced extra-domain A (EDA) of fibronectin in the neovasculature of metastases and primary tumors of human cancer patients was shown, TSG-6 is a high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells, These data provide the first evidence that IL-18 and FN stimulate each other's expression., These results suggest that fibrinogen and fibronectin facilitate the adherence of Paracoccidioides brasiliensis conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system., dominant mutations in FN1 accounted for 40% of cases of Glomerulopathy with fibronectin (FN) deposits in our study group, These results are consistent with the hypothesis that ScpB binds to a motif created by the juxtaposition of multiple Fn molecules., The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin., Filtering bleb scarring is associated with an abundant expression of TGF-beta receptors in activated fibroblasts and the deposition of the fibrogenic ED-A fibronectin splice-variant., MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, KLK7 is able to cleave fibronectin in a time-dependent manner, but not laminin., Increased production of a fibronectin isoform containing the oncofetal domain and its release in the circulation in patients with primary biliary cirrhosis is at least partially responsible for the decrease in bone formation., Results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development., A link between fibronectin expression and epithelial cell growth during development and oncogenesis in the mammary gland., Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., Inflammation-induced modulation of FN-isoform production is involved in the alterations of migratory potential of CLPF isolated from CD mucosa., elevated plasma fibronectin levels are associated with venous thromboembolism (VTE) especially in males, and extend the potential association between biomarkers and risk factors for arterial atherothrombosis and VTE, four crystal structures that together comprise the structures of two complete high-affinity binding repeats for Fn from FnBPA and FnBPB, each in complex with four of the N-terminal modules of Fn, Plasma fibronectin level is increased in patients with severe coronary artery disease, namely, those who have at least one critically stenosed coronary vessel, compared to patients with normal coronary arteries., analysis of fibronectin expression in benign hyperplasia and cancer of the prostate, These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Genotyping for HaeIIIb fibronectin gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in mixed cryoglobulinemic syndrome., a new mechanism of fibroblast activation, which is initiated by interaction of fibronectin with its integrin receptors., MAGE A3 is a functional integrator of diverse signals, including FGFR2 and FN, to modulate cancer progression., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., The simultaneous positivity for thyroid specific factor TTF-1 and onfFN suggest they might represent putative thyroid cancer stem-like cells., analysis of the unfolding of the tenth type-III repeat of human fibronectin, Dynamic mechanical forces could regulate the expression of collagen type I and fibronectin mRNA in periodontal ligament fibroblasts., Mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and FNI(9)., enhanced capacity of fibronectin-adherent HL60 cells to differentiate into macrophages in response to PMA., The 320-kDa and 280-kDa FN forms as well as FN fragments appeared in the pleural effusion and plasma of patients suffering from lung inflammation or cancer in significantly higher relative amounts in both lung cancer groups than in the inflammation., relative amount of EDA-FN in synovial fluid, but not in plasma samples, was significantly lower in the early RA group than in established and late RA. In contrast, its level did not correlate with the CRP concentration, The risk of pneumoconiosis increases in workers with the FN (MspICC or HaeIIIb AA) genotype after exposure to dust. Workers both carrying FN (HaeIIIb AA) and (MspICC) genotypes are more susceptible to pneumoconiosis., role for fibronectin in collagen proteolysis and tissue remodeling, Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30., These results established a novel in vitro dynamic BBB model. We also demonstrated the dependence of leukocyte-endothelial interactions in this model on alpha4 integrins and FN-CS1., Human umbilical vein endothelial cells showed dose-dependent upregulation of fibronectin mRNA exposed to various D-glucose levels., Borrelia burgdorferi virulence factor BBK32 induces the formation of Fn aggregates that are indistinguishable from those formed by anastellin., isoforms of a group B streptococcus-secreted component named Fib displayed differential binding capacities for fibronectin, fibrinogen, and C4BP, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., fibronectin might be a critical molecule produced by T(H)1 cells involved in pathogen eradication., the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., LigB was shown to bind to the N-terminal domain of fibronectin., HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease, FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases., Serum fibronectin concentration in patients with hemorrhagic fever with renal syndrome (HFRS) was increased with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity., higher expression in the fetal skin than in adult skin, AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., Exposure to high glucose and overexpression AR increase the expression of fibronectin., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., the third FN type III repeat (FnIII3) and several fragments containing the repeat promote cell spreading and migration of human dermal fibroblasts (HDFs), whereas the fourth repeat (FnIII4) did not., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., vaginal fetal fibronectin not changed by vaginal ultrasound, Upregulation of fibronectin-1 protects Dicer knockdown HEK293T cells against apoptosis., findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., Increase in urinary fibronectin is associated with bladder tumor., The identification of a fibronectin-binding domain in ameloblastin might permit interesting applications for dental implantology., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., iso-DGR sequences spontaneously converted from NGR are cryptic and do not mediate the interaction of the 70K region of FN with the cell surface during FN assembly, Mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human cancer cells., Data demonstrated that the inclusion of the alternatively spliced angiogenesis-associated ED-B leads to the unmasking of the FNIII 8 B-C loop that is cryptic in FN molecules lacking ED-B., Exposure to ethanol drastically enhances the adhesion of cultured breast cancer cells to fibronectin and increases the expression of focal adhesions., Fibronectin promotes paxillin (tyr118) phosphorylation and invasiveness of AGS cells., An increased expression of fibronectin and tenascin-C mRNA in association to histological damage and in valvular heart disease compared to coronary artery disease could be shown., Fibronectin may modulate the directional migration of corneal epithelial cells, The expression of Col I, Col IV and Fn was closely related to tumor invasion, the regional lymph node metastasis and other pathological features in laryngeal squamous cell carcinoma., our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells., Steric hindrance determines the motogenic activity of MSF and Fn, and that both molecules contain cryptic bioactive fragments., in the presence of laminin and fibronectin, DC maintain a 'more immature' phenotype and express higher levels of key endocytic receptors, and become better endocytic cells, but possess superior ability to induce antigen-specific T cell differentiation., Oncofetal fibronectin transcripts are highly abundant in the peripheral blood of patients with papillary thyroid carcinoma., Elevated urinary fibronectin was identified as an independent factor predicting kidney function deterioration., Data show that metastatic outgrowth is associated with activation of the transforming growth factor-beta signaling pathway and concerted up-regulation of POSTN, FN1, COL-I, and VCAN genes., plays role in bronchial smooth muscle cells migration in the process of airway remodeling, Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac activation by mGBP-2., Data show that occupancy of EPCR by protein C switches signaling specificity so that activation of PAR-1 by thrombin inhibits TNF-alpha-mediated synthesis of IL-6 and IL-8 and down-regulates TGF-beta-mediated expression of collagen type 4 and fibronectin., MSF is a novel marker associated with the M2 stage of macrophage polarization expressed by tumor-conditioned macrophages; MSF may contribute to macrophage-mediated promotion of cancer cell invasion and metastasis., high molecular weight of HA suppressed the FN-f-activated p38 via ICAM-1 and the CD44 in RA chondrocytes, Migration Stimulating Factor, a truncated form of fibronectin that promotes the migration of many cell types, inhibits AKT activity in human fibroblasts, data indicate that higher levels of EDB isoform and FN-f are associated with intervertebral disc degeneration; this shift in alternative splicing may reflect an attempt of tissue repair and remodeling, FN induces MMP-9 in HEp-2 cells mainly by involving integrin receptor alpha5beta1 and involves activation of multiple signaling pathways which independently or in "cross-talk" to each other finally leads to the transactivation of the MMP-9 gene., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, Fetal fibronectin as a predictor of spontaneous preterm birth., Data show that FN III12-14 is a highly promiscuous ligand for GFs and also holds great potential in clinical healing applications., FN upregulates osteoclast activity despite inhibiting osteoclast formation and that these effects involve NO and IL-1beta signaling., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., Tenascin-C contains cryptic sites which can control tissue levels of fibrillar fibronectin either by preventing de novo fibril assembly or reducing levels of deposited fibronectin., In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal., The findings that fibroblast survival is dependent on FN-growth factor binding domains underscore the critical importance of pericellular matrix for cell survival, CTGF cooperates with FN in enhancing the attachment and migration of corneal epithelial cells., Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion., IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin, High FN1 mRNA expression is associated with renal cell cancer., rhFNHN29 and rhFNHC36 inhibit adhesion and invasion of liver cancer cells, syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides, study suggests that FN and tissue transglutaminase (TG2) facilitate the metastatic activity of A431 tumor cells, and this may be partly attributed to TG2 enhancement of the association of FN and beta integrin, These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins., Megakaryocyte adhesion to type I collagen promotes inhibits pro-platelet formation through the release of cFN to the plasma membrane. This regulatory mechanism is dependent on the engagement of FN receptors and on transglutaminase FXIII-A activity., autocrine soluble fibronectin of osteosarcoma MG-63 cells may be involved in cell shape maintaining, Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve., FN upregulation of cGMP-dependent protein kinase (PKG-I) protein content is due to increased mRNA expression via augmented transcriptional activity of the PKG-I promoter region., Cav1.2 calcium channel association with alpha5beta1-integrin depends on adhesion to fibronectin; interactions between alpha5beta1-integrin and fibronectin modulate L-type calcium channel entry., Fetal fibronectin may be used as a primary screening tool for prediction of preterm birth in asymptomatic high-risk women., Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP., Danshensu can protect from oxidative stress through inhibiting the expression of FN and Col-I induced by high glucose., Kindlin-2 regulates podocyte adhesion and fibronectin deposition through interactions with phosphoinositides and integrin b1 and b3., Data show that ITP-79 modulated binding of TG2 to fibronectin., LigB could facilitate leptospirosis transmission by binding fibronectin and fibrinogen, Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression., Increase expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas., This work provides a broad overview of matrix remodeling at the cell-material interface, establishing correlations between surface chemistry, fibronectin adsorption, cell adhesion and signaling, matrix reorganization and degradation., We conclude that TGF-beta1 may both switch on and switch off migration stimulating factor (MSF) expression in a manner critically determined by the nature of the matrix substratum, Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage, Data show that the urinary messenger RNA (mRNA) levels of alpha-smooth muscle actin (alpha-SMA), fibronectin, and matrix metalloproteinase-9 (MMP-9) were significantly higher in the diabetic nephropathy (DN) group, and mRNA levels increased with DN progression., Structural and functional analysis of the tandem beta-zipper interaction of a Streptococcal protein with human fibronectin, Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn., The adhesive properties and thickness of the UspA1 layer at the cell surface varies on addition of either fibronectin or CEACAM1., miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line., the extent of molecular unfolding that contributes to Fn fiber extension, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted AGS cell migration was due to the up-regulation of fibronectin., Fibronectin matrix assembly suppresses dispersal of glioblastoma cells, Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier, Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein, first step in such infections is a bond that forms between fibronectin-binding protein (FnBP) on Staphylococcus aureus and host proteins, such as fibronectin (Fn), that coat the surface of implants in vivo., Data indicate that anti-citrullinated fibronectin peptide antibodies are associated with HLA-DRB1 shared epitope alleles., Allosteric loss of constraining interactions among (1-5)FNI, (10)FNIII, and (12-14)FNIII likely enables assembly of FN into extracellular fibrils., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, these findings provide evidence that extra domain A of fibronectin could play a role in tumor-induced lymphangiogenesis via upregulating autocrine secretion of VEGF-C in colorectal cancer, which is associated with the PI3K/Akt-dependent pathway., Study demonstrated that fibronectin inhibition and neutralization by specific antibody prevented significantly the adhesion of A. baumannii to human lung epithelial cells (A549 cells)., study concludes that increased serotonylation of fibronectin occurs in pulmonary hypertension, Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin, High expression of fibronectin is associated with esophageal squamous cell carcinoma., Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC)., Genistein attenuates advanced glycation end product-induced expression of fibronectin and connective tissue growth factor, Collagens regulate the EDA(+)-FN-ECM organisation at transcriptional and post-transcriptional level and activate the alpha5beta1-FAK complexes., Gene expression profiles showed that FN1 was up-regulated in epidermolysis bullosa subtypes., Reduced expression of two specific integrin subunits, alpha 5 andalpha V, resulted in the inability of MG63 cells to deposit fibronectin into their extracellular matrix, influenza A Virus entry with a alpha2,6-linked sialic acid binding preference requires host fibronectin, MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., FN1 assembly and the lung colonization of suspended CL1-5 cells were inhibited when endogenous A1AT protein was knocked down using siRNA., MSF functions in the metabolic remodeling of the tumor microenvironment., Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin., our results suggest that plasma PTPalpha and fibronectin may be associated with opisthorchiasis., Data indicate that fibronectin mRNA and protein levels were significantly down-regulated following the upregulation of serine protease HTRA1., Serum oncofetal fibronectin mRNA in differentiated thyroid carcinoma cannot identify those with metastatic disease., FN1 and ITGA4 are potential oral squamous cell carcinoma biomarkers for tongue/mouth floor and edentulous ridge., Data indicate that rheumatoid synovial fibroblasts have impaired adhesion and spreading on citrullinated fibronectin, but focal matrix degradation is unaffected by citrullinated fibronectin., We confirm WNT4, CDKN2BAS and FN1 as the first identified common loci for endometriosis., An algorithm based on fetal FN for management of preterm labor (PTL) does not reduce evaluation times for triage, hospital admissions or preterm deliveries., Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression in the U87 glioblastoma cell line, Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., Lactobacillus iners AB-1 displays a mechanism of vaginal persistence to human fibronectin, with implications for human reproductive health., Authors report that group A Streptococcus biofilm formation is mediated by the Scl1 interaction with extra domain A-containing cellular form of fibronectin., Data indicate that citrullinated fibronectin (cFn) plays a potential pathophysiologic role in rheumatoid arthritis (RA) by inhibiting apoptosis and increasing proinflammatory cytokine secretion of fibroblast-like synoviocytes (FLSs)., Data indicate that four different Anticalins all show low nanomolar affinities for fibronectin (Fn) extra-domain B (ED-B)., MOMCs were obtained on the fibronectin., Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of fibronectin., genome-wide association study of population in Northern Belgium, Data indicate that endopeptidase O (PepO) is a ubiquitously expressed plasminogen- and fibronectin-binding protein, which plays role in pneumococcal invasion of host cells and aids in immune evasion., The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8., Treated neutrophils aggregate on fibronectin (Fn)-coated wells and exhibit an exaggerated cell aggregation phenotype on wells coated with Fn plus beta-glucan., The metabolism of glucose through hexosamine biosynthetic pathway promotes O-glycosylation of the oncofetal form of FN during epithelial-mesenchymal transition modulating tumorogenesis., fibronectin is a key factor in human serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture., Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis., High glucose and AGEs can up-regulate the expressions of ROS and fibronectin in human mesangial cells by activating transcriptional co-activator p300., Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN)., Collagen association stabilizes a distinct monomeric fibronectin gelatin-binding domain conformation in solution., Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer., The predicted 23-residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with the tenth FN type III domain., We identified 31 interactors from plasma, of which only seven were previously known to interact with fibronectin, Data indicate tht mRNA expression of elastin, procollagen I type I, fibronectin, Col1alpha1, and TIMP-1 had a significant increase after bicyclic[1,2,3]triazoles plus UVA treatment, while the MMP-1 decreased, compared with the UVA irradiated group., We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, MSF expression was upregulated in NSCLC tumors and promoted migration and invasion in A549 cells., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, Four members from clusters of the miR-200 family (miR-200a/-200b/-429 and miR-200c/-141), epithelial-mesenchymal transition could potentially play a role in the pathogenesis of pterygium., Low extra domain A fibronectin expression is associated with bacterial meningitis., The SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Data suggest that determination of the fibronectin content can serve as a prognostic biomarker for breast and prostate cancers and possibly other cancers., Together these results show that FN produced by the tumor cells has a role in glioblastoma multiforme pathophysiology and they provide insights into the implications that targeting FN interactions may have for combating this dreaded disease., profile of fibronectin fragmentation and alterations of fibronectin domain immunoreactivities in seminal plasma may influence their engagement in the fertilisation process, First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for gestational diabetes., We demonstrate that the high FN content of the endometrium matrix, and not specifically the EDA domain, supports trophoblast invasion by showing that forced incorporation of plasma FN (EDA-) promotes efficient trophoblast invasion, Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy., Perturbing the mesenchymal regulators, platelet-derived growth factor (PDGF) receptors or fibronectin, reverts mesenchymal stromal/stem cells (MSCs) toward mesodermal progenitors with endothelial potential., cFN isoform expression in the TM ECM may be a novel pathologic mechanism involved in the TM changes associated with glaucoma., expression of miR-206 and its target gene, fn 1, may contribute to the progression of bronchopulmonary dysplasia, Fibrillins require the complete gelatin-binding region of fibronectin for interactions., Fibronectin is upregulated in a subset of nasopharyngeal carcinomas , and its increased immunoexpression significantly correlated with advanced features, justifying the potentiality of fibronectin as a theragnostic biomaker of nasopharyngeal carcinomas ., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., the dual antibody approach utilizes commercially available antibodies and simple immunohistochemistry, thus making it accessible to a wide range of scientists interested in fibronectin mechanobiology, Oncofetal fibronectin levels are potentially useful as a biomarker for urothelial inflammation and repair., Eppin and Fn bind to each other in human semen and on human ejaculated spermatozoa., Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens., Identify FN1(high)MITF(low) cell type in melanoma associated with ischemic necrosis, and propose these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment., This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in Duchenne muscular dystrophy patients., Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis., Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5., Data indicate that ibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA) is sterically regulated by fibronectin binding., Most of these motifs are located on the F1 and F3 faces of the Hap passenger domain structure, suggesting that the F1 and F3 faces may be responsible for the Hap passenger domain-fibronectin interaction., Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition, We proved that the CD157-fibronectin interaction occurs with living cells, where it elicits CD157-mediated cell responses., MMF could inhibit MCP-1 expression and the secretion of FN, indicating that it may delay the progression of glomerulosclerosis and interstitial fibrosis in diabetic nephropathy to ultimately achieve protective effects on the kidney., Data indicate the expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in cardiac tissue from heart transplant recipients., The mean level of cellular fibronectin expression in cases with liver fibrosis was significantly higher than the corresponding level in cases with liver cirrhosis., rFN/CDHs may induce hMSCs differentiation into osteoblasts and PLGA/collagen nanofibers loaded with rFN/CDHs have potential in bone tissue engineering., The AT heterozygote in FN-1 (rs940739A/T) was found to be significantly associated with knee osteoarthritis in 2 case-control studies. FN-1 rs6725958C/A was significant only if both studies were combined., Results found that the majority of colorectal cancer cases with depressed tumors had a higher frequency of elevated FN1 expression., High fibronectin expression is associated with thyroid papillary carcinoma follicular variant., the possible regulatory effect of fibronectin peptides in liver fibrosis was further supported by the ability of these peptides to induce metalloprotease-9 (MMP-9) expression in human monocytes., homophilic fibronectin binding peptides might have novel applications in the field of tissue regeneration as tools to regulate neovascularization via VEGF signaling, serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells., Study tested the role of the histone acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon; these data suggest that histone acetylation could be one of the mechanisms how promoter and promoter binding proteins influence alternative splicing., Data indicate that the IL-33/ST2 protein pathway may promote airway remodeling in asthma through activating HLF-1 fibroblast to over-express fibronectin 1 (FN1) and type 1 collagen (Col1)., fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis, These results have indicated that the cysteine proteinase of Trypanosoma cruzi metacyclic forms, through its fibronectin-degrading activity, is implicated in host cell invasion., PEDF inhibited breast cancer cell migration and invasion by down-regulating fibronectin, Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour., Data indicate that the interaction between the alpha4beta1 integrin and the EDA domain of fibronectin helps to drive tissue fibrosis by promoting a contractile phenotype and an increase in fibronectin synthesis and deposition., The expression of terminal sugars on milk FN is different from that of plasma FN of the lactating mother and is associated with milk maturation., Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells., Fibronectin gene expression has a potential role in the pathogenesis of keloid., Genetic induction of fibronectin by HER2 triggers cell adhesion and invasion capacities., Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin and collagens by a laminin-rich matrix, we describe a new type of hybrid molecules including 10th type III human fibronectin domain (10Fn3) - one of the alternative scaffold proteins which can be used for the construction of antibody mimics with various binding specificity, Serum fibronectin was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. Fibronectin increased with nephropathy severity., Fn Msp iv polymorphism appeared to be associated with diabetic nephropathy susceptibility., Serum- and CSF-FN levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis., These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway., Data show that the amount of the the extra domain-B (EDB) splice variant of fibronectin (FN) produced by endothelial cells increases with matrix stiffness., The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, An observed increase in PLD activity was mediated through boosting the binding of PLD with dynamin which in turn facilitated fibronectin-induced cell spreading., Asthmatic human bronchial epithelial cells are intrinsically primed to produce more fibronectin, which when deposited into the extracellular matrix, is capable of driving remodeling and inflammation., The pathogenic H5N1 and H7N9 influenza virus variants cause more severe deregulation of NRF2 and fibronectin in host epithelial cells than the less pathogenic H1N1 variant., Study determined the structure of third type III domain, 3FN3 using nuclear magnetic resonance spectroscopy, and investigated its stability, folding, and unfolding., polymorphisms in rs6725958, rs10202709, and rs35343655 of the Fn gene had no obvious effect on the susceptibility to the development of calcium oxalate stones in the Uighur population, residing in the Xinjiang region of China., Fibronectin binding to heparan sulfate mediates exosome-cell interactions in Myeloma., the correlation between placental DNAm of INHBA/FN1 and maternal serum INHA/FN1 levels indicate that DNAm may be a useful tool to identify novel biomarkers for adverse pregnancy outcomes in some cases., that strong FN1 promoter activity drives inappropriate expression of the biologically active portion of EGF, These results suggest novel functions of endogenous FN involved in immune evasion and maintenance of hepatitis b virus replication.,
OFFICIAL_GENE_SYMBOL FN1,
OMIM_DISEASE Glomerulopathy with fibronectin deposits 2, Plasma fibronectin deficiency,
SP_COMMENT alternative products:Additional isoforms seem to exist, developmental stage:Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age., disease:Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life., function:Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth., online information:Fibronectin entry, PTM:Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)., PTM:It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated., PTM:Sulfated., similarity:Contains 12 fibronectin type-I domains., similarity:Contains 16 fibronectin type-III domains., similarity:Contains 2 fibronectin type-II domains., subunit:Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7., tissue specificity:Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.,
integrin subunit alpha 5(ITGA5) integrin subunit alpha 5(ITGA5) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q11-q13,
ENSEMBL_GENE_ID ENSG00000161638,
GENERIF_SUMMARY alternative pathway of pro-alpha(v) processing involving MT1-MMP, The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits., role in mediating adhesion and migration of activated cycling CD34+ hematopoietic progenitor cells onto fibronectin, Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast, Central role of alpha5beta1 integrin in vascular development in mouse embryos and embryoid bodies., TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression, The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro., results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., B. pertussis FHA up-regulates ICAM-1 expression on respiratory epithelial cells through interaction of its RGD site with host cell VLA-5 integrin, and that PT impairs this response, Elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton., integrin alpha5beta1 extracellular domain controls rhoA activity, Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, identification of binding site in gamma C-domain of fibrinogen, alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, The structural conformation of this protein, complexed wigh integrin beta1, complexed with fibronectin, is examined., Disulfide bonding patterns of the integrin alpha 5 chain are demonstrated; new insights into a second bond between the heavy and light chains of alpha 5 are described., Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., The integrin, alpha 5 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., the alpha5 integrin subunit has a role in the induction of apoptosis triggered by FGFR2 activation in osteoblasts, and a Cbl-dependent mechanism is involved in the coordinated regulation of cell apoptosis induced by alpha5 integrin degradation, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, alpha3, alpha5, and alpha6 beta1 integrins are expressed in ductal cells at 8 weeks, before glucagon- and insulin-immunoreactive cells bud off in fetal pancrea., ITGA5 mediates engraftment of GCSF-mobilized stem cells., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, one mechanism by which IGFBP2 activates IGFBP2-induced cell mobility is through its interaction with integrin alpha5 and this interaction is specifically mediated through the RGD domain on IGFBP2, binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins, Alpha5beta1 (VLA-5) integrin is a major galectin-1-glycosylated counterreceptor involved in immune developmental synapse formation., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, activities for cell spreading and migration for the alpha5 subunit carrying only three potential N-glycosylation sites (3-5 sites) on the beta-propeller were comparable with those of the wild type, integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., surface micron-scale topography modulates alpha(5)beta(1) integrin binding and FAK activation, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Interaction of alpha-toxin with alpha5beta1-integrin and overproduction of TNF-alpha may contribute to destruction of epithelial cells during S. aureus infection., Modulation of cell adhesion is a normal physiological action of PTHrP, mediated by increasing integrin gene transcription., This study identified the beta1 integrins on primary smooth muscle cells that fibulin-5 interacts with, and showed that failure of fibulin-5 to activate these receptors limits cell spreading, migration and proliferation., OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest possible participation of alpha5beta1 integrin in the mechanism of local invasion of ameloblastomas, KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta, There is low expression of the proteins and mRNA of ME491/CD63 and integrin alpha5 in ovarian cancer. The lower the pathological differentiation is, the more significant the loss of expression is and the more likely metastasis is., Protein expression of ITGA5 decreased at labour and expression of these molecules was also observed in primary cultured human uterine SMCs., Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Integrin alpha5 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., analysis of important residues within the central turn motifs present in the cytoplasmic tails of integrin alphaIIb and alphaV subunits, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin., Both integrins, v3 and v5, are involved in the glioma cell radioresistance through the integrin-linked kinase (ILK) and the small GTPase RhoB, at least by regulating the radiation-induced mitotic cell death., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell, The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., TM4SF5 facilitates angiogenesis of neighboring endothelial cells through VEGF induction, mediated by cooperation between TM4SF5 and integrin alpha(5) of epithelial cells, findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III., This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, inhibition of the alpha5beta1 integrin reduces lymphangiogenesis in inflamed airways after M. pulmonis infection, The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., These results suggest that alpha(5)-integrin up-regulation induced by E-cadherin loss under hypoxia has a crucial role in regulating the migration of extravillous trophoblast cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., Induction of alpha5-integrin expression is a key determinant by which inhibitors of TGFbeta type-I receptor kinase and VEGF synergistically promote angiogenesis., upregulated expression in lung adenocarcinoma cells following bacterial infection, new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., These findings not only reveal that ITGA5 is required for osteoblast differentiation of adult human mesenchymal stromal cells (hMSCs) but also provide a targeted strategy using ITGA5 agonists to promote the osteogenic capacity of hMSCs., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., This study demonstrates that an important antiinflammatory aspect of glucocorticoids is regulating the expression and function of alpha5 integrin., 17beta-estradiol enhances alpha(5) integrin subunit gene expression through ERalpha-Sp1 interaction and reduces cell motility and invasion of ERalpha-positive breast cancer cells., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1, Transfection of the alpha1,2-fucosyltransferase gene into ovarian carcinoma-derived cells brought about elevated expression of integrin alpha5beta1 with Le(Y)., Integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim., EGF may influence proliferative vitreoretinopathy by promoting integrin-alpha(5) expression and subsequent proliferation and migration of retinal pigment epithelial cells., in the presence of alphavbeta3-integrin Rac1 is not required for tumor angiogenesis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction., Interaction between IGFBP2 and integrin alpha5 accelerates cell adhesion, and this, in turn, enhances JNK-mediated glioma cell migration., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Downregulation of ITGA5 is associated with multiple myeloma., Findings indicated the diverse roles of ITGA5 expression in breast cancer cells., The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., We propose that alpha(5)beta(1) integrin, which is associated with cholesterol-rich microdomains at the host cell surface, is required for NOD1 recognition of peptidoglycan and subsequent induction of NF-kappaB-dependent responses to H. pylori., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., investigation of role of ITGA5 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 calcium channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., RNA interference-mediated knockdown of CD49e (alpha5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion., Integrin 5 1 facilitates cancer cell invasion through enhanced contractile forces, In cultured intervertebral disc cells, fibronectin fragment increased the expression of MMP9,MMP13m alpha 5 and beta1 integrin via the alpha5beta1 integrin receptor., Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, The expression of the alpha5 gene in human uveal melanoma cell lines, was characterized., elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., The endoproteolytic cleavage of alphav subunits is necessary for alphavbeta5/beta6 integrin to control alpha2beta1 function and could thus play an essential role in colon cancer cell migration., Data suggest that colorectal cancer (CRC)-derived integrin alphavbeta6 is involved in the establishment of tumor immune tolerance in local tissues., growth defects in mesenchymal stromal cells in myelodysplastic syndromes were significantly correlated with decreases in CD44 adhesion molecules and CD49e., study here indicated that integrin alphaVbeta3 had lower affinity when the ADMIDAS was mutated, WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Rv2468c engaged integrin VLA-5 (alpha5beta1) on CD4+ T cells through its FN-like RGD motif GRDGSPK., alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1., ZEB2 was found to activate integrin alpha5 and vimentin promoters by interacting with and activating transcription factor Sp1, suggesting that cooperation between ZEB2 and Sp1 represents a novel mechanism of mesenchymal gene activation during epithelial-mesenchymal transition, uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, betaig-h3 co-localized with integrin alpha5beta1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule., Specific adhesion of megakaryoblasts to fibronectin via both alpha5- and alpha4-integrin molecules and phorbol 12-myristate 13-acetate (PMA) is essential for pro-platelet-like formation of megakaryocytes., Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., PKCalpha constitutes a crucial component of the integrin alphav-mediated pathway(s) that promote p53 relocalization and melanoma survival., Tauroursodeoxycholic acid induces in perfused rat liver and human HepG2 cells the rapid appearance of the active conformation of the beta subunit of alpha5beta1 integrins, followed by an activating phosphorylation of extracellular signal-regulated kinases., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., Co-expression of c-Met and Integrin alpha5beta1 has mechanical significance in the early stages of human gastric cardia adenocarcinoma., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., miR-148b controls malignancy by coordinating a novel pathway involving over 130 genes and, in particular, it directly targets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110alpha, and NRAS, as well as CSF1, High Integrin alpha5beta1 expression is associated with metastasis of colorectal cancer., Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., Calreticulin, integrin-alpha5, and TGF-beta1 expression was increased in atrial tissue in patients with AF and was related to AF type, suggesting that calreticulin is involved in the pathogenesis of AF in VHD patients., The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells., These findings support a direct role for Survivin in melanoma metastasis, which requires alpha5 integrin and suggest that inhibitors of alpha5 integrin may be useful in combating this process, Data indicate that nuclear integrin alphav monomer in T4-exposed cells, but not integrin beta3, bound to promoters of specific genes that have important roles in cancer cells., MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, the identification of ITGA5 -E2/3 splice variant as potential novel adverse prognostic marker for low-risk AML, We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, loss of BRM epigenetically induces C/EBPbeta transcription, which then directly induces alpha5 integrin transcription to promote the malignant behavior of mammary epithelial cells, 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Integrin alpha5beta1 overexpression is associated with lymph node metastasis and vascular invasion in cervical cancer., our results identify a novel regulatory pathway involving the interplay between ZO-1, alpha5-integrin and PKCepsilon in the late stages of mammalian cell division., High integrin alphaVbeta6 expression is associated with liver metastasis in colorectal cancer., Herpes simplex virus gH/gL sufficed to elicit type I IFN and NF-kappaB activation via alphavbeta3 integrin in epithelial and neuronal cell lines., these results establish that GP IIb/IIIa and alphavbeta3 integrins are essential mediators of shear flow-induced cancer cell mechanotransduction, Integrin alpha5-FAK signaling pathway controls the proliferation of bladder smooth muscle cells in response to cyclic hydrodynamic pressure., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach., Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., RhoC facilitates tumor cell invasion and promotes subsequent metastasis, in part, by enhancing integrin alpha5beta1 trafficking, We have demonstrated for the first time a new molecular pathway that connects TMPRSS4 and integrin alpha5 through miR-205 to regulate cancer cell invasion and metastasis, Overexpression of integrin alpha v is closely associated with metastasis and progression of nasopharyngeal carcinoma., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, phenotype of mice with alpha5-erythroid deletions was similar to controls, especially after stress. These outcomes seem to reconcile divergent prior views on the role of alpha5-integrin in erythropoiesis., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., In the presence of both 9-cis-retinoic acid and troglitazone, cell surface alpha5 subunit expression was restored to levels comparable to vehicle treatment alone., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., Data show that thyroid hormones induce mitogen-activated protein kinase (MAPK) via integrin alphavbeta3 in bone marrow-derived cells from multiple myeloma (MM)., demonstrate that alpha5 integrin turnover is dependent on fibronectin matrix assembly, Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., Data indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Mesodermal expression of integrin alpha5beta1 regulates neural crest development and cardiovascular morphogenesis., Data indicate that influenza A virus H1N1 infection activated alphavbeta6 integrin-dependent transforming growth factor beta (TGFbeta) activity in immortalized bronchial epithelial cells (iHBEC)., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2, Data indicate that alpha5 integrin (ITGA5) is a functional target of miroRNA miR-26a-induced anoikis in hepatocellular carcinoma (HCC) cells., Twist1 and AP-1 cooperatively upregulate integrin alpha5 expression to induce invasion and the epithelial-mesenchymal transition.Twist1 expression positively correlates with integrin alpha5 expression in human colorectal cancers., we detected higher activity of AKT (p = 0.011) and FAK (p = 0.054), higher integrin alpha5 expression (p = 0.052) and lower PTEN expression in primary cells from patients with bone metastasis compared to nonmetastasizing cells., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Integrin alphanubeta6-mediated MMP-9 secretion facilitates pericellular matrix degradation at high cell density, promoting invasive growth of colonic neoplasms., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway., Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Collagens considerably suppressed alpha5 gene expression in CECs, suggesting that during wound, Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1., Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer, The present study has revealed an integrin- and membrane lipid raft-dependent mechanotransduction mechanism by which atheroprone flow causes endothelial dysfunction., integrin alpha5 might play important roles in the progression of esophageal squamous cell carcinoma, knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased,
OFFICIAL_GENE_SYMBOL ITGA5,
SP_COMMENT function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
integrin subunit beta 1(ITGB1) integrin subunit beta 1(ITGB1) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10p11.2,
ENSEMBL_GENE_ID ENSG00000150093,
GENERIF_SUMMARY the linkage between beta1 integrin and actin may be differentially regulated by its tyrosine and serine/threonine phosphorylation in normal and cancerous breast cells., Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling, Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction, both VEGF-induced PI 3-kinase activation and beta(1) integrin-mediated binding to fibronectin are required for the recruitment and activation of PKC alpha., Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines., Although cytoplasmic splice variants do not change the ligand-specificity of a beta 1 integrin, this review explains how clustering of different splice variants triggers signaling pathways that lead to a different cellular response., beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican, These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells., Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, Data demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins such as CD151 are palmitoylated, and that palmitoylation is not required for cd151-alpha3beta1 integrin association., Activated Notch4 inhibits angiogenesis, role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding, mechanical stress to the beta1-integrin subunit in osteoblasts revealed that cyclic forces of 1 Hz were more effective to stimulate the cellular calcium response than continuous load, beta1 and beta2 integrins activate different signalling pathways in monocytes., Inv-induced cell death was mediated via beta1-integrins since Inv bound to the beta1-integrin subunit (CD29), anti-beta(1)-integrin antibodies blocked Inv-induced cell death and Inv-induced cell death was absent in two beta1-integrin- cell lines., Beta1 integrin triggering affects leukemic cell line sensitivity to natural killer cells, Evidence for distinctive signaling of CD82- and beta1 integrin-mediated costimulation at the transcriptional level of IL-2 gene., There is a desensitization of IL-8-mediated p42/p44 MAPK signaling in response to ligation of the alpha5beta1 integrin in PMNL. There may be an interplay between integrin and chemokine signaling during PMNL migration through the extracellular matrix., Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines, Ionizing radiation strongly induced the expression of functional beta1-integrin and ILK in the two lung cancer cell lines, A549 and SKMES1., mediates adhesion of osteosarcoma to the core region of thrombospondin 1 (alpha 4 beta 1 integrin), role in regulating beta 1 integrin-dependent leukocyte adhesion, results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, VLA4 integrin activation by chemokines requires cholesterol, role of Rap1 GTPase for Mn(2+)- and antibody-induced VLA-4-mediated cell adhesion [VLA-4], Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., Data show that, in vitro, under physiological conditions, CD98 is constitutively associated with beta1 integrins regardless of activation status., Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, data suggest that overexpression of beta 1-integrin confers resistance to apoptosis in hepatoma cells via a MAP kinase dependent pathway, regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47, role in mediating pro-angiogenic activity of CYR61, beta1 integrin engagement is required for bombesin-dependent pro-MMP-9 activation in prostatic cancer cells, initial adhesion of endometrial cells to mesothelium is not mediated by beta1 integrins but attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins, molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes, findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought, Temporal gene expression profile of precursor B leukemia cells induced by ITGB1 identifies pathways regulating B-cell survival., results are consistent with an essential role for beta(1) integrins in maintenance of cardiomyocyte viability and interaction with extracellular matrix, Data show that the expression of the PAINS-13 epitope depends on CD9 association with alpha(6)beta(1) integrin., Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., beta1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by its gC1q domain, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1, integrin beta1 cytoplasmic peptides self-associate; role in beta1 integrin clustering and formation of focal adhesions, beta(1) integrin has a role in the syndecan-4 pathway for cell spreading, along with PKCalpha and RhoA, Overexpression of AKT2/protein kinase Bbeta leads to up-regulation, increased invasion, and metastasis of human breast and ovarian cancer cells., that the expression of beta(1C) integrin, a very efficient inhibitor of cell proliferation, may be modulated by the maternal microenvironment and may play a fundamental role in mediating trophoblast outgrowth and migration during pregnancy., Results establish, for the first time, mutation as a mechanism by which integrins can contribute to neoplasia., Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, beta1 integrin has a role in selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, determination of crystal structure in complex with an antibody Fab fragment, Data show that NADPH oxidase activation production of reactive oxygen species are involved in the increase of alpha2beta1-integrin plasma membrane expression in Caco-2 cells stimulated with type IV collagen., endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., expression of beta1 integrin subunit is responsible for differentiation-associated changes in cells behavior in terminally differentiated oral keratinocytes, capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation., adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated in platelets, identification of binding site in gamma C-domain of fibrinogen, Decidual beta1 integrin and FAK participate in this final step of implantation., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alpha 6 beta 1 binds to CCN1, Alpha4beta1 integrin has a role in cell adhesion, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, cells overexpressing beta 1-integrin exhibited increased proliferation in response to hepatocyte growth factor., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., identify intracellular signals involved in integrin BETA1-initiated internalization of S. aureus, in beta-thalassemic patients, significant reduction of CD49d, CD29 and CD71 antigen expression was found in peripheral blood nucleated red cells, upon treatment with phorbol esters, K562 cells become adherent and permissive for parvovirus B19 entry, which is mediated by alpha 5 beta 1 integrins, but only in their high-affinity conformation, alpha6beta1 integrins have roles as thrombospondin receptors in microvascular and large vessel endothelial cells, Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit., S-phase delay induced by overexpression of integrin beta1 subunit caused by decrease of protein kinase B phosphorylation and subsequent increases of p21(cip1) and p27(kip1) proteins. May be involved in unoccupied alpha5beta1 because of lack of ligands., Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin., In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels., The beta1-integrin-ligand disengagement resulted in capillary disruption and stimulated p38 MAPK and extracellular signal-regulated kinase activity., beta1 integrin/FAK-mediated signaling on osteoblasts could be involved in ICAM-1- and RANKL-dependent osteoclast maturation, results suggest that beta1 integrin is a common receptor for AfaD invasins and that additional AfaD-type-specific receptors exist, The structural conformation of this protein, complexed wigh integrin alpha5, complexed with fibronectin, is examined, Reduced beta1 integrin-mediated cell adhesion of HME cells to the substratum during mitosis may be induced by beta1 integrin phosphorylation at threonines 788-789 and its reduced ability to link with the actin cytoskeleton., role in ganglioside GM3 blocking of epidermal growth factor receptor, following priming of human neutrophils with lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha), addition of formyl-Met-Leu-Phe (fMLP) results in a "stimulated", sepsis-like, four- to fivefold rise in CD49d expression, the failure of beta1 integrin dephosphorylation at threonines 788 and 789 may be due to a significant reduction in the PP2A-A expression in tumor cells, integrin beta1 interacts with galectin 1, Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin., human platelet deposition on collagen depends on the concerted interplay of several receptors, Data demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of putative pancreatic progenitors on Netrin-1., ligand-binding specificities of integrin alpha3beta1 and alpha6beta1, Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., alpha3beta1 integrin binding to laminin-5 depends on its proteolytic processing, beta1C integrin splice variant is transcriptionally regulated in human prostate adenocarcinoma, integrin alpha4beta1 is induced by p53 and has a role in B-cell chronic lymphocytic leukemia drug resistance, Key role of the regulation of beta 1C integrin expression in the pathogenesis of endometrial proliferative diseases, results suggest that a direct interaction occurs between the Adenovirus penton base protein and the integrin receptor alpha3beta1 in vitro and in vivo, results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes, alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, Data show that stimulation-dependent recycling of integrin beta1 is regulated by ARF6 and Rab11, and also requires the actin cytoskeleton in an ARF6-dependent manner., results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling, Alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis., beta1 integrin maturation and transport to the cell surface is regulated by low density lipoprotein receptor-related protein-1, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta I-like and alpha I domain activation involves structurally analogous alpha7-helix axial displacements., beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis., EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions, findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells, Overexpression of integrin beta(1)modifies the response of I(Ca)to beta-adrenergic receptor stimulation., conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation, very late antigen-4 affinity is modulated by shear, alpha2beta1 integrin has a role in endorepellin-induced endothelial cell disassembly of actin cytoskeleton and focal adhesions, role in chemotaxis in conjuction with plasmin, Increases in IGF-IR decrease beta1 integrin expression, and enhance cell migration in neuroblastoma cells., alpha2beta1 integrin and GPVI regulate stress fiber formation in megakarocytes, the primary actin structures needed for cell contraction, Calu-1 lung cancer cells use primarily a beta1-integrin-mediated intracellular tyrosine phosphorylation phenomenon as the key regulatory mechanism for its binding advantage to Coll IV matrix., alpha 3 beta 1 integrin is necessary and sufficient for maximal keratinocyte survival on laminin-5, alpha4beta1 integrin on sickle reticulocytes is a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides., cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin, ILK regulates alpha 2 beta 1 in HEL cells, is activated in platelets and associates with beta 1-integrins, integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., 16K expression inhibits beta(1) integrin surface expression and spreading on matrix by a novel mechanism that results in reduced levels of functional beta(1) integrin, alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis, The integrin, beta 1 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes, Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., Activation of PI3K following beta1-integrin engagement on human CD34+ cells results in subsequent phosphorylation of PYK2, and is required for the recruitment of the PI3K/PYK2 complex to beta1-integrins at the cell surface., Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of hepatocellular carcinoma cells to laminin., demonstrates a cooperative role between alpha5beta1 and alpha4beta1 integrins and suggests that interactions between the Hep II domain and alpha4beta1 integrin could modulate the strength of cytoskeleton-mediated processes in the trabecular meshwork, ICAM-1 molecules interacted only with group B Streptococcus(GBS)-III liquor 90356 strain while beta1 integrin interacted with GBS-III liquor 90356 and GBS-V blood 90186 invasive strains, VEGF-C and VEGF-D are ligands for the integrin alpha9beta1, The expressive fluorescent intensity of integrinbeta(1) in G(1) phase SMMC-7721 cells was depressed more significantly than the values of S phase., analysis of transcriptional regulation of beta1 integrin expression in endometrium and endometrial neoplasms, Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Results indicate that CD151 association modulates the ligand-binding activity of integrin alpha3beta1 through stabilizing its activated conformation not only with purified proteins but also in a physiological context., JAM1 regulates epithelial cell morphology and beta1 integrin expression by modulating activity of the small GTPase Rap1., Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., integrin beta1 function is modulated by CD98 in polarized epithelial cells, VEGF and alpha4beta1 integrin have roles in chemokine-induced motility on and through endothelium in chronic lymphocytic leukemia cells but not in normal B lymphocytes, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, Interacts with vimentin, but this association is lost after prolonged adhesion of endothelial cells to collagen., Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation., Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway, activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion, KSHV gB can activate VEGFR-3 on the microvascular endothelium and modulate endothelial cell migration and proliferation via an interaction between the alpha3beta1 integrin and the VEGFR-3 receptor, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, matrix-derived mechanical forces sensed by beta1 integrin are capable of modulating ILK activity which regulates fibroblast viability via an Akt-dependent mechanism, alpha3beta1 integrin binding results in a suppression of the interleukin-1 signaling pathway leading to the activation of NF-(kappa)B, alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density, FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, analysis of platelet glycoprotein I(b)alpha and integrin alpha2beta1 polymorphisms in diverse populations, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, Expression pattern of integrin subunits in the human fetal pancreas (8-20 weeks fetal age) and the relevance of beta1 integrin function for insulin gene expression and islet cell survival., PDGFR-dependent cell detachment is induced by S1P via inhibition of beta1 integrin in HEK293 cells, Three intracytoplasmic motifs of the tail of VLA-4 beta 1 subunit differentially regulate VLA-4-mediated adhesive functions under static adhesion and shear flow conditions., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1, the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, phenotypic conversion and reversion of bladder cancer cells is controlled by a glycosynapse 3 microdomain through GM3-mediated interaction of alpha3beta1 integrin with CD9, Results provide evidence for a novel species of beta1 integrin on the cell surface, which does not appear to be associated with any alpha chain., alpha2beta1 and signaling via autocrine mediators facilitate and amplify the GPVI procoagulant activity of fibrillar and non-fibrillar collagens, IFN-gamma attenuates epithelial wound closure by microtubule-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of focal adhesion complexes and cell migration., mapping of the N-glycosylation sites on the beta1 integrin to better understand the potential effects of differential sialylation on integrin structure/function, The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells., Cells deficient in beta1 integrin can bind human ADAM12 via beta3 integrin., the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia, suggests beta1-integrins as critical regulators of cell survival after radiation-induced genotoxic injury, beta 1 integrin has roles in cell adhesion and migration in development and metastasis [review], beta1 integrin is critical for the alveolar morphogenesis of a glandular epithelium and for maintenance of its differentiated function, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, isolated beta1 cytoplasmic domain expression induces caspase-independent detachment of viable endothelial cells and that death is secondary to detachment (i.e. anoikis), Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain, Our data show that alpha3beta1 integrin function may be altered by glycosylation, that both subunits contribute to these changes, and glycosylation may be considered a newly found mechanism in the regulation of integrin function., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., Platelets, by binding via P-selectin to PSGL-1 on monocytes, induce up-regulation and activation of beta1 and beta2integrins and increased adhesion of monocytes to activated endothelium., The Integrin beta1 thrombogenic polymorphism and FcgammaRIIA expression could play a role in platelet sensitivity to collagen in type 2 diabetes., The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., decreased podocyte expression of alpha3beta1 integrins is closely related with podocyte depletion, glomerular sclerosis, and daily protein loss in patients with primary focal glomerulosclerosis, facilitates reovirus internalization and suggest that viral entry occurs by interactions of reovirus virions with independent attachment and entry receptors on the cell surface., IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., This study supports matrix-induced clustering of alpha3beta1 integrin promotes uPAR/alpha3beta1 interaction; potentiating cellular signal transduction pathways culminating in activation of uPA expression and enhanced uPA-dependent invasive behavior., EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization, urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, Beta1-integrin subunit is identified as a new gastrin-regulated gene in human pancreatic cancer cells., Data indicate that integrin beta1 plays a major and complex role in osteoblastic differentiation modulated by either surface microarchitecture or 1alpha,25(OH)2D3., RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR., Slug regulates integrin alpha3, beta1, and beta4 expression and cell proliferation in human epidermal keratinocytes, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, Data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells., These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells., Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer., The formation of dendrites is shown to require the interaction between the beta1-integrin (CD29) on the surface of the DCs and fibronectin in the extracellular matrix., Data show that the integrin beta1 repertoire in renal cell carcinoma is different from normal proximal tubule cells, and that valproic acid acts on all investigated integrin subtypes to restore the receptor pattern typical for non-malignant cells., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, This is the first demonstration that the integrin beta1 tail can regulate centrosome function, the assembly of the mitotic spindle, and cytokinesis., Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies., Salivary progenitor epithelial cell survival is beta 1 integrin-dependent., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, Results show that alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells., results indicate that exported alpha-toxin inhibits the adhesion and internalization of S. aureus by interfering with integrin-mediated pathogen-host cell interactions., integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, comparison of DOCK2 and Vav1 involvement in CXCL12-promoted Rac activation and alpha4beta1-dependent human T cell adhesion indicated a more prominent role of Vav1 than DOCK2, IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry, Primary human mesenchymal stem cells are able to induce self-renewing divisions of hematopoietic progenitor cellsby a beta(1)-integrin-dependent mechanism., Results show that coculture with ECs enhances VSMC adhesion and spreading by up-regulating beta(1)-integrin expression and activating the PI3K/Akt pathway. Interaction between ECs and VSMCs serves a role in vascular homeostasis and remodeling., decrease of beta(1)D-integrin & FAK in ischemic cardiomyopathy; loss of beta(1)Dintegrin-FAK-complex in ICM paralleled by reduced AKT activity supporting in vitro data showing role of intact integrin function in anti-apoptotic signaling & cell survival, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, IL4-induced FBGC are characterized by the expression of alphaMbeta2, alphaXbeta2, alpha5beta1, alphaVbeta1, alpha2beta1, and alpha3beta1, which indicates potential interactions with fragments of C3, fibrin(ogen), fibronectin, Factor X, and vitronectin, alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells, Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner., The integrin activation level, assessed by binding of soluble collagen to the alpha2beta1 integrin, was reduced upon cell treatment with DT. The TS2/16, an anti-beta1 activating monoclonal antibody was able to rescue DT-treated cells from apoptosis., High affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells., These experiments identify a new compound that can interfere with biological processes by inhibiting microdomain formation and also identify beta1 integrin as a potential mediator of signaling by GSLs., Lubrol-RAFTs probably represent the platform for tumor-promoting ephrin-B2-integrin-beta1 interaction, which could become an interesting target for future antitumoral therapies, integrin beta1 has a role in inhibiting cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway, both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, These results suggest that engagement of beta1 integrins on systemic lupus erythematosus T cells could induce FAK-mediated signaling and subsequent CD40L expression and proliferation., These results indicate that binding of the alpha3beta1 integrin results in a suppression in the activation of the IL-1 induced intracellular signaling pathway from JNK to AP-1., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest an important role of integrin alpha2beta1, alpha3beta1, and alpha5beta1 in the architectural characteristics of ameloblastomas and adenomatoid odentogenic tumor, In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression., Data show that in bullous pemphigoid, expression of beta1 was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., This study identifies alpha2 beta1 integrin as an important regulatory pathway of IFN-gamma expression and provides novel insights into the signaling mechanisms of integrin costimulation in T cells., The VCAM-1/very late activation antigen 4 adhesive system critically mediates endothelial progenitor cell adhesion to cultured rheumatoid arthritis fibroblasts and to rheumatoid arthritis synovial tissue, LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, support a model in which KAI1/CD82 attenuates the maturation of the beta1 integrin precursor and thereby suppresses cell migration, T-cadherin may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in squamous cell carcinoma by regulating surface level of beta1 integrin, talin 1 is a versatile VLA-4 affinity regulator implicated in both spontaneous and chemokine-triggered rapid adhesions to VCAM-1., results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment, No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy., Beta1 and alpha3 integrins are functionally important receptors for type 1 pili-expressing bacteria within the urinary tract and possibly at other sites within the host., CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells, Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation., CXCR4 contributes to renal carcinoma cells (RCC) dissemination and may provide a novel link between CXCL12 expression and integrin beta1 triggered RCC adhesion to the vascular wall and subendothelial matrix components, Np-1 confers a growth and survival advantage to pancreas cancer cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness., The process of dynamic integrin regulation may be an important part in tumour cell migration strategy, switching the cells from being adhesive to becoming motile and invasive., identification of alpha3beta1 as the predominant integrin and laminin receptor in glioma cells, and as a brain invasion-mediating integrin, IGF-I receptor and beta1-integrin signaling may play an important role in protective effect of hyaluronic acid on interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, TGF-beta2 promoted human lens epithelial cell adhesion and migration in vitro. Integrin beta1 and integrin-mediated signaling are necessary for TGF-beta2-promoted adhesion and migration in human lens epithelial cells., The expression of beta1-integrin was found to be significantly reduced in photoaged skin and ratios of the expressions of involucrin to beta1-integrin were increased 2.6-fold only in elderly subjects., These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal., These results strongly suggest that enhanced expression of alpha3beta1 integrin on hepatocellular carcinoma cells is directly involved in their malignant phenotypes such as invasion and metastasis., The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an extracellular matrix-dependent and integrin-mediated manner., These data demonstrate that activation of Epac1 increases integrin activity and integrin-dependent homing functions of progenitor cells., tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation., results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion, Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells., Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins., The physiologically relevant organ culture assay employed here is a potential research tool for exploring whether targeted stimulation of beta1 integrin-mediated signalling is a suitable candidate for human hair loss management., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin., Integrin beta1 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., Integrin beta 1 transgene is involved in the phagocytosis of certain bacteria, including group B streptococcus and Staphylococcus aureus, and critically regulates phagosome maturation through Rac expression., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., Beta1 integrin/Fak/Src signaling translates into integrated mediating functions of p38b activation and regulation of Bcl-2 homologs by PI3-K/Akt-1 and MEK/Erk, consequently determining their requirement (or not) for survival., B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44., H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin-JNK pathway, HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, Hypersialylated beta1 integrin is endogenously expressed in human astrocytoma cell lines., Show a critical role of PKCdelta in the regulation of renal carcinoma cell migration, which seems to be caused by affecting the expression and activity of beta1 integrins and focal adhesion kinase., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes, key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., The data suggest that phosphoenolpyruvate -dependent decrease of collagen biosynthesis in cultured human skin fibroblasts may undergo through depression of alpha(2)beta(1) integrin and IGF-IR signaling., CD151 regulates integrin alpha3beta1 functions in two independent aspects, TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation[review], Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients, study reports that T cell costimulation by the integrin VLA-4 (alpha4beta1) required SLP-76 domains implicated in microcluster assembly, Integrin alpha2beta1 may promote migration and invasion of neuroblastoma cells., Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., These results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of enterotoxin function and rotavirus pathogenesis, further distinguishing this viral virulence factor from other microbial enterotoxins., The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., LPS or peritoneal dialysis effluent stimulated the adherence of T cells to mesothelial cells, a process mediated by the integrins alpha6beta1 and alpha4beta1, Chemotherapy-induced overexpression of integrin b1 in some multiple myeloma patients upregulates LRP expression in bone marrow cells, inducing antineoplastic drug resistance., Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis ., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, gal-3 binds directly and preferentially to unsialylated, as compared with alpha2-6-sialylated, beta1 integrins, EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Results suggest that HAb18G/CD147 enhances the invasion and metastatic potentials of human hepatoma cells via integrin alpha3beta1-mediated FAK-paxillin and FAKPI3K-Ca(2+) signal pathways., Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., The mRNA levels of integrin beta1 and ILK protein were significantly higher in laryngeal carcinoma than in the surrounding tissue and vocal cord polyps., These data data suggest that, in migrating intestinal epithelial cells, beta(1)-integrin is internalized via a dynamin-dependent lipid raft-mediated pathway., Preferential downregulation of beta1-integrin expression on progenitor cells can reduce the tethering forces to BM components, thus facilitating their egress to the peripheral circulation during an allergic inflammatory response., SEMA3A suppression of tumor cell migration is dependent on alpha2beta1, the expression of which is stimulated in breast tumor cells by an autocrine SEMA3A pathway., tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges., analysis of distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens., These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The integrin beta1-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas., VLA-4, a heterodimer of CD49d and CD29, is the most important adhesion molecule for cell-adhesion-mediated drug resistance in multiple myeloma cells., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins, Our results argue for the involvement of galectin-1 in the PKCepsilon/vimentin-controlled trafficking of integrin-beta1, Overexpression of GluR1 positively correlated with glioma cell adhesion to type I and type IV collagen which was decreased in cells with blocking antibodies to beta1 integrin, NO targets activation-dependent adhesion mediated by alpha(2)beta(1), possibly by reducing bioavailability of platelet-derived ADP, but has no effect on activation-independent adhesion mediated by GPVI, analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1, The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789., overexpression of ITGB1 may be related to resistance to chemotherapy in esophageal squamous cell carcinoma, These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth., Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a "vicious cycle" between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction., Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state., Suggest that the specific interaction of MCT4 with beta(1)-integrin may regulate cell migration through modulation of focal adhesions., mechanisms by which TF induces estrogen receptor alpha expression in breast cancer involve both PAR2 and beta(1)-integrin, Integrin-beta1 was overexpressed in oral leukoplakia, and may correlate to the proliferation of the dysplasia cells., TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., Functional live-cell imaging demonstrates that ITGB1 promotes type IV collagen degradation by breast and prostate cancer cells., alpha 3, alpha 6A, and beta 1 integrin expression in cancer cells at the invasive front are related to the mode of invasion and prognosis in oral squamous cell carcinoma, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Results suggest that prostaglandin E2 mainly induces the activation of beta(1)-integrins via the EP(2) receptor in human coronary arterial endothelial cells., Stress application to activated beta1 integrins increases Galphas recruitment and activates these large G proteins within focal adhesions, JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration., findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, Expression of a genetic variant in the I-like domain of beta1 integrins does not affect normal epidermal homeostasis, but increases skin tumor susceptibility and influences tumor type in transgenice mice., High levels of VLA-4 is associated with mantle cell lymphoma., Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects, These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function, This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp., Cdc42 activity is impaired in beta1 integrin-deficient T cells that form conjugates with antigen-presenting cells but is partially restored in the context of an antigen-specific synapse., Data showed that tumor-associated matrices induced PI3K and beta1-integrin dependent Akt/PKB activity in MDA-MB-231 cells., These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence., Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN., Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin., TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling., alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization, Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, Compared with open surgery, laparoscopy-assisted radical gastrectomy is not associated with a greater effect on the expression of ICAM-1 and integrin beta(1) in peritoneal mesothelial cells., These findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, These findings support a role for FLNa-beta1 integrin as a mechanosensitive complex that bidirectionally senses the tension of the matrix and, in turn, regulates cellular contractility and response to this matrix tension., decreased expression on allograft T cells of healthy bone marrow donors following Granulocyte colony-stimulating factor pretransplant conditioning, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, The presence of the alpha11 integrin chain during early corneal development and the enhanced expression in scarred keratoconus corneas indicates that integrin chain is likely to play an important role in collagen deposition during corneal development, In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., these results highlight for the first time the considerable role of the integrin alpha6beta1 in glioma progression., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche, Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., A GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation., is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1], Interactions between type I collagen and beta1 integrins augment apoB secretion by Caco-2 cells., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes, a central role for alpha2beta1 integrin in experimental and developmental angiogenesis, upregulated expression in lung adenocarcinoma cells following bacterial infection, Musashi-1 and beta1-integrin may be involved in human colorectal tumor carcinogenesis and progression., ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway., AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression., Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations., new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., Among laminin-binding integrins, mast cells express alpha3beta1 (but not alpha6beta1, alpha7beta1, or alpha6beta4) integrins., Gal-3 promotes epithelial cell migration by cross-linking MGAT5-modified complex N-glycans on alpha3beta1 integrin., Integrins alpha3beta1 and alpha6beta1 are important cell surface receptors that mediate the chemotaxis of hepatocelluar carcinoma cells toward laminin., Integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 to mediate tumor invasion and metastatic processes., Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP, ERbeta affects integrin expression and clustering and consequently modulates adhesion and migration of breast cancer cells., although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Detecting intracellular Erk1/2 phosphorylation and IL-2 and IFN-g production, study confirmed that multiple signals, including VLA-4 engagement, are necessary for maximal T-cell activation beyond that induced via the TCR and CD28., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads., Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., beta(1)-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients, Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., in its entry strategy human echovirus 1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor, results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Targeting of integrin beta1 and kinesin 2alpha by microRNA 183., Induced integrin alpha5 and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest., Collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and this effect is mediated by the interaction of collagen with integrin alpha2beta1., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., These results suggest that both gangliosides and beta1-integrin are required for maintenance of caveolae and plasma membrane domains., conserved NPXY and TT motifs play important roles in the tissue-specific function of integrin, Data suggest that integrin alpha(2)beta(1), glycoprotein Ib and vWf interactions with collagen I and III contribute to platelet adhesion under high shear flow., DSCs-expressed CD82 up-regulates the expression of TIMP1 in an autocrine manner and inhibits the invasiveness of human first-trimester trophoblast cells partly through the integrinbeta1/MAPK/MAPK3/1 signaling pathway, Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1., Increased uPAR expression promotes alpha(3)beta(1) integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors., the binding of filamin A to vimentin and protein kinase C epsilon is an essential regulatory step for the trafficking and activation of beta1 integrins and cell spreading on collagen, Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Data show that the L-plastin/integrin complex is regulated by mu-calpain cleavage and is not directly dissociated by calcium., Integrins may initiate the cellular response of osteocytes to dynamic fluid flow and may serve as mechanosensitive molecules in bone., The results demonstrate definitely that major quaternary rearrangements of beta1-integrin subunits occur in adherent cells and that conversion from a bent to extended form takes place at focal adhesions., Pancreatic beta cell mesenchymal transition and decline in insulin gene expression are induced by elements of the ECM, by b1-integrin ligation, and by signaling via Src, JNK, and ERK., The expression of Integrin beta1 decreases when the differentiation level of squamous cell carcinoma cells increase., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., Indicate that the integrin beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures., Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function., Inhibition of integrin beta1 reduced the adhesion forces of trophoblast cells to type I rat collagen or endothelial cells., Measurement of thrombus height after specific receptor blockade or use of altered proportions of peptides indicates a signaling rather than adhesive role for glycoprotein VI, and primarily adhesive roles for both alpha(2)beta(1) and the VWF axis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, The results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix., Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways., alpha4beta1-mediated tumor lymphangiogenesis promotes metastasis, Activation of ss1-integrin in human umbiilical vein endothelial cells (HUVEC) is specifically affected by depletion of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)., The authors identify beta(1) integrin, which is expressed by naive B cells of distinct lymphoid origin and by memory B cells from nasal mucosa-associated lymphoid tissue, as a mediator of increased susceptibility to infection by Epstein-Barr virus., Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion., up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions, Integrin beta 1 may play an important role in the development of hepatic fibrosis, hepatic cirrhosis and hepatocellular carcinoma., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Prostate tissue-derived CD133+ cells exhibited a high level of expression of beta1 integrin, The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., Inhibition of beta1 integrin function rescued proliferation and cyclin E1 expression as well as c-Myc expression and Rb phosphorylation., when beta(1)A is unligated, beta(1)B is responsible for "integrin-mediated death" in human keratinocytes, Recombinant or microparticle-associated tissue factor stimulate endothelial cell proliferation through activation of the ERK 1/2 pathway, mediated through a novel mechanism requiring the interaction of exogenous TF with cell surface beta1-integrin., Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration., Eight different anti-integrin beta1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed., Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, decreasing beta1 chain causes alphavbeta3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity., Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis., The HCMV gB-DLD protein bound to fibroblasts in a specific, dose-dependent and saturable manner that required the expression of an intact beta1 integrin ectodomain., alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, Findings argue strongly that beta1-integrin can both potentiate CMG2-mediated endocytosis and serve independently as a low-affinity PA receptor., plays a key role in the pathogenesis of pustulosis Palmaris et Plantaris, Calcium regulates integrin beta1 activity and expression and cell migration of HaCaT cells., Inhibition of beta1 integrin expression by DNAzyme to beta1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro., The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration., our data indicate that CCR7 regulate cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck, SIRPalpha facilitates cross-talk between the prolactin receptor (PRLr) and beta1 integrin and provides a basis for extracellular matrix regulation of PRLr action in breast cancer., Data confirmed reduced CD9 expression in MDS CD34+ and bone marrow mononuclear cells., U937 macrophage responses to the TLR2 ligand, Pam3CSK4, are dependent upon integrin alpha3beta1., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., Data show that coculture of ALL cells with MSCs induced on the lymphoblast plasma membrane the expression of a signaling complex formed by hERG1, the beta(1)-integrin subunit, and the chemokine receptor CXCR4., Data suggest that up-regulation of integrin beta1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2., Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction., the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells, Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression., Both wild-type and internal tandem duplication (ITD)-FLT3 proteins co-immunoprecipitated with beta1 integrin and Pyk2 indicating the signal crosstalk between FLT3, beta1 integrin and Pyk2., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions., Structural diversity in integrin/talin interactions., alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival, ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, investigation of role of ITGB1 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors., Data show that interactions between beta1 integrin and ErbB4 occur in a spatiotemporally-regulated manner, and such interaction contributes to the integrin-dependent cell migration., Ameloblastoma cells proliferate and are differentiated by capturing perlecan differentially with alpha-dystroglycan and integrin beta1, respectively, expression of VLA-4 in PBMC of hemorrhagic fever with renal syndrome (HFRS) patients at different stages were higher than normal controls, except recovery stage; VLA-4 might play an important role in the immunopathological lesions of HFRS, These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways., High expression levels of CD151 and alpha6 promote invasiveness of HCC cells. Either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC., Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells., kindlin-2 promotes integrin b1 and b3 activation., expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection., The extra nuclear AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. Assembly of this ternary complex may control organ development and prostate cancer metastasis., Data suggest that integrin alpha6beta1 is an important cell surface receptor that mediates the adhesion of the SMMC-7721 hepatocellular carcinoma cell line to type IV collagen., stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream beta1 integrin function, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., High integrin beta 1 is associated with invasive lobular cancer in comparison with other breast tumor types., a novel mechanism by which beta1 integrin regulates matrix metalloproteinase-10 expression during lymphatic vessel remodeling, Significant to anoikis-related regulation, the delay in caspase-8 activation was accompanied by the maintenance of FAK Tyr397 phosphorylation, integrin beta1-associated FAK and a FAK/caspase-8 complex., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., P-selectin, on eosinophil-associated activated platelets or acquired from plasma or from prior interactions with endothelial cells/platelets, activates eosinophil beta1 integrin, stimulating eosinophil adhesion to VCAM-1 and move to the airway in asthma., a direct interaction between the Oca-family member NadA and human beta1 integrins., in endothelial cells, ligation of alpha2beta1 and alpha6beta1 integrins induces the Notch pathway, and we disclose a novel role of basement membrane proteins in the processes controlling tip vs stalk cell selection, results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy., HOXD1 plays a significant role in endothelial cells functions by regulating the expression of ITGB1., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8, Pancreatic stellate cells radioprotect pancreatic cancer cells through beta1-integrin signaling, The effect of SDF-1 on colorectal cancer cell signaling and urokinase-type plasminogen activator (uPA) expression is mediated by the CXCR4/beta1 integrin axis., maspin, uPAR, and beta1 integrin co-immunoprecipitate, suggesting a novel maspin-uPA-uPAR-beta1 integrin mega-complex that regulates mammary epithelial cell adhesion., these findings show that epithelial-mesenchymal transition and its down-regulated expression of E-cad circumvent breast cancer dormancy in part by facilitating beta1 integrin expression necessary for metastatic outgrowth., High serum ITGB1 is associated with gastric cancer., The results showed that overexpression of Id1 enhanced cell migration and increased beta1-integrin expression, In osteoblasts exposed to dexamethasone, ILK expression was slightly increased, whereas there was substantial reduction in that of beta1 integrin., Both DCC and integrin bindings interfere with microtubule binding to myosin X., Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1., data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88, Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces., Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., beta1 integrin-mediated adhesion is upregulated during T lymphocyte extravasation by activating Galpha subunit-dependent inside-out signaling., MSC migration is controlled by CD73 & CD29, which in turn are regulated by mechanical stimulation of cells, elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins., when lung fibroblasts are attached to collagen matrix, the beta1 integrin/Src/PP2A-mediated 4EBP-1 regulatory pathway is activated, Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase)., The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells., Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators., These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration., SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations., Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner., In malignant melanoma, CD147/basigin regulates integrin beta1 signaling via the phosphorylation of focal adhesion kinase., There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration, Talin1 is required for inside-out activation of integrin beta1 during Bartonella henselae infection., Left ventricular assist device-induced reversed remodeling did not result in significant integrin protein expression, although changes in integrin mRNA expression suggested an adaptation to unloading., WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells., the integrin beta1 signaling pathway has an important role in regulating the nanofiber-induced fibroblast phenotypic alteration, examined integrin beta(1) , ECAD and rac1 expression in SCLC and analyzed the prognostic value of these markers, a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route, Results demonstrate differential effects of Snail and Slug in pancreatic cancer and identify the interplay between Rho signaling and beta1-integrin that regulates the scattering and migration of Snail- and Slug-expressing pancreatic cancer cells., Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., these data collectively indicate that beta1-integrin-related cell death is closely associated with EMT phenotypes and activation of the p53-p21 pathway is partly involved in the acquisition of resistance to apoptosis induced by beta1-integrin silencing., uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells, IGFBP2 activates integrin beta1 and downstream invasion pathways. The IGFBP2/integrin/ILK/NF-kappaB network functions as a physiologically active signaling pathway in vivo by driving glioma progression., Recombinant expression plasmid integrin-beta1- shRNA can inhibit the expression of integrin-beta1 gene and suppress the invasion of pancreatic carcinoma cells in vitro significantly., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression, The expression of beta1-integrin in glia is crucial for the proper development of the cerebellar cortex, whereas its expression in granule neurons is dispensable for cerebellar development., Dephosphorylation of FAK upon inhibition of beta integrin resulted in dissociation of a FAK/cortactin protein complex. This, in turn, downregulated JNK signaling and induced cell rounding, leading to radiosensitization., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer., analysis of the role of RICTOR in beta1 integrin-mediated cell survival and how receptor-specific mechanisms regulate phosphorylation of AKT at Ser473, Integrin beta1-mediated cellular adhesion to fibronectin confers drug resistance to mitomycin-C on bladder cancer cells. Knockdown of integrin beta1 may abolish the drug resistance phenotype and sensitize bladder cells to mitomycin-C., This study demonstrates that integrin beta1 mediates EGF-induced cell invasion in ovarian cancer., demonstrate with loss-of-function and rescue experiments that CD9 activates and MMP8 inactivates beta1 integrins and that both proteins associate with beta1 integrins in cells, The findings indicated that integrin a6b1 promotes the survival of brain endothelial cells by inhibiting prodeath signaling by TNF-R1, in part by inducing cellular FLICE inhibitory protein expression., Integrin b1/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial cells., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin beta1 sialylation, crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, The number of glycine residues in the PH domain is the key difference underlying the differential actions of cytohesin 2/ARNO and cytohesin 3/GRP1 in cell adhesion, spreading and beta1 integrin recycling., describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, The live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton., Integrin beta1 mediates vaccinia virus entry through activation of PI3K/Akt signaling., Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin., beta1 integrins should sense the stimulation of fluid shear stress and thus activate ERK1/2 through activating of FAK., The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome., decreased GnT-V activity due to inflammatory cytokine induction in human monocytes resulted in enchancement of integrin alpha5beta1-dependent monocyte-vascular endothelium adhesion and transmigration, There is no association between platelet collagen receptor polymorphisms GP VI T13254C or GP Ia C807T (alpha2beta1Integrin) and premature acute myocardial infarction in the Iranian population., These data suggest that Dab2-mediated recruitment of EH domain proteins selectively drives the internalization of the Dab2 cargo, integrin b1., Kindlin-2 and talin head do not interact with one another but can bind simultaneously to the integrin beta(3) tail without enhancing or inhibiting the interaction of the other binding partner., The regulation of alpha4beta1-dependent adhesion and migration of myeloma cells by CXCL12-S1P combined activities might have important consequences for myeloma disease progression., alpha5beta1 integrin transgene demonstrates an important angiogenic role by promoting brain endothelial cell proliferation in response to cerebral hypoxia., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit, Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., Combination of CD29 and CD44 can be used as markers to enrich cancer stem cells in human squamous cell carcinoma with epithelial-mesenchymal transition., These findings indicate that integrin beta1 has a major impact on HNSCC prognosis through its regulation of metastasis., CD151 links alpha(3)beta(1)/alpha(6)beta(1) integrins to Ras, Rac1, and Cdc42 by promoting the formation of multimolecular complexes in the membrane, which leads to the up-regulation of adhesion-dependent small GTPase activation, Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation., Tauroursodeoxycholic acid can directly activate intrahepatocytic beta integrins, which trigger signal transduction pathways toward choleresis., It was shown that mutations in the integrin beta1 tail NPXY motifs in the kidney produce phenotypes different from those seen in constitutive and skin-specific knock-ins., Provide further evidence that beta1 integrin can be a marker of poor prognosis in breast cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., Most actinic cheilitis cases showed reduced expression of integrin beta1 and superficially invasive squamous cell carcinoma lacked intergrin beta1 in the invasive front., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., In astrocytes transfected with a chimeric beta1 subunit, its activation is sufficient to cause centrosome assembly in the absence of cell adhesion., Data indicate that alpha3beta1 and the tetraspanin CD151 directly associate at the front and retracting rear of polarised migrating breast carcinoma cells., while alpha5beta1 integrin cross-linking contributes to the bacillus Calmette-Guerin response, it alone is insufficient to duplicate the full spectrum of bacillus Calmette-Guerin induced changes in urothelial carcinoma cell biology., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth., Examined the role of beta1 integrin in exocrine pancreatic structure and function. Compared with control pancreata, beta1 integrin-deficient pancreata showed reduced mRNA expression of extracellular matrix (collagen type Ialpha2, fibronectin and laminin) genes., Data show that TIMP-2-mediated inhibition of vascular endothelial cell permeability involves an integrin alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association., Gal-3 expression enhances beta1 integrin-mediated cell adhesion and cell migration., The chemokine domain of fractalkine binds to integrins alpha4beta1 and alphavbeta3., Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation., NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in renal cell carcinomas malignancy., Beta1 integrin is the main target for Cdc42-mediating interaction of cancer cells with endothelial cells and the underlying extracellular matrix, as exogenous beta1 integrin expression was sufficient to rescue the Cdc42-silencing phenotype., Expression of alpha and beta integrin subunits is increased on peripheral blood T cells in patients with asthma, study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation, Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced intracellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-dependent Akt activation, Mechanotransduction through beta(1)-integrins, FAK and p38 is required for anti-inflammatory effects of steady shear stress., data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone., Data indicate that Slug siRNA suppressed the TGF-beta1-induced integrin alpha3beta1-mediated cell migration ability of squamous cell carcinoma HSC-4 cells., Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation., The role of beta1 integrins and of a beta1 downstream target, c-Jun amino-terminal kinase 1 (JNK1), in regulating radiation-induced apoptosis in prostate cancer was studied., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation., osteopontin, LAMB3 and ITGB1 played important roles in the occurrence and metastasis of lung cancer, thus provided important clues to understanding the molecular mechanism of metastasis., beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma., Aberrant expression of E-cadherin and integrin beta-1 is closely related to malignant transformation and hydatidiform mole development., a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported., Data suggest that ITGB1 is critical ligand to enhance cell-extracellular matrix contact force and thus promotes cell proliferation; ITGB1 knockdown affects leiomyomal cell spreading but not adhesion; ITGB1 may function in progression of leiomyoma., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, Timp1 is assembled in a supramolecular complex containing CD63 and beta1-integrins along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway., Integrin beta1 interacts with SPARC in prostate cancer cells and suppresses cell proliferation and migration., provide the first evidence that beta(1) integrin-dependent migratory and metastatic competence of prostate cancer cells is enhanced by Trop-2, The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1., Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation., an important role of AnxA2 in controlling dynamics of beta1 integrin at the cell surface that in turn is required for the active turnover of cell-matrix associations, cell migration, and wound closure., Findings indicate that interactions between beta1-integrin and NF-kappaB p65 were induced in nonmalignant breast epithelial cells, but not in malignant cells, indicating context-specific regulation., Suggest that fibronectin fine tunes LM332-mediated migration by boosting bronchiolar cell adhesion to substrate via integrin alpha3beta1 integrin., High integrin beta 1 expression is associated with radioresistance in astrocytoma., Both CD9/CD81-silenced cells and CD151-silenced cells showed delayed alpha3beta1-dependent cell spreading on laminin-332., Integrin beta-1(+) and p75NTR(+) cells play an important role in wound healing process, MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, lipid raft integrity was required for beta1 integrin-mediated initial spreading of melanoma A375 cells on fibronectin., The data suggest that integrin beta1 is a potential biomarker for lymph node metastasis and prognosis of lung adenocarcinoma and integrin beta1 upregulation may play an important role in the pathogenesis of lung adenocarcinoma., These results showed evidence of Borrelia burgdorferi BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein., A specific association between alpha4beta1 and CD81, CD82 and CD151 was demonstrated and antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., changes in p38 mitogen-activated protein kinase expression together with recycling of adhesion receptors from the endosome leads to endothelial cell adhesion., These results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in beta1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells., 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., beta1-Integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer., These data uncover a potential role for PKP2 upstream of beta1 integrin and RhoA in integrating cell-cell and cell-substrate contact signaling in basal keratinocytes., integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion, NG2 knockdown results in loss of beta1 integrin activation in endothelial cells, revealing a mechanism for NG2-dependent cross talk between pericytes and endothelial cells., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, Expression of the VLA-4-stimulating factor sequence may help to predict melanoma prometastatic risk., Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., expression of beta1 integrin in OECM-1 cells is involved in the development of malignant phenotypes of OSCC, Data indicate that all mesenchymal colony clusters displayed a predominant CD44+/CD24- phenotype with decreased HER-2 expression and elevated levels of a beta1-integrin isoform with a high degree of N-glycosylation., CD44v6 and integrin-beta1 mRNA and protein expression in blood may serve as biomarkers for the development and metastasis of pancreatic cancer, Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells., Autophagy regulates cell migration, a central mechanism in cell development, angiogenesis, and tumor progression, by mitigating the cell surface expression of beta1 integrins., MARVELD1 plays a role in pre-mRNA processing of integrin beta1., the alpha1 integrin subunit in Bone marrow-derived mesenchymal stem cells is important for their ability to stimulate vessel morphogenesis., ss1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion., Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury., Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., The present study demonstrates miR-134-mediated negative regulation of beta1 integrin that influences cell adhesion to and of mesenchymal stem cells., Data indicate that levels of CXCR4 and VLA-4 did not predict acute lymphoblastic leukemia (ALL) prognosis in children, but Analysis of CXCR4 and VLA-4 levels at diagnosis in adults with ALL can provide useful information on patient prognosis., alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., Data show that nucleolin is a critical lipid-raft-dependent beta1-integrin-interacting protein in A375 melanoma cell spreading and migration on fibronectin., High VLA-4 expression is associated with brain metastasis., data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells., Data indicate that macrophage-derived exosomes regulate integrin beta1-dependent migration of endothelial cells., beta1 integrin signaling in human epithelial progenitor cell, SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin beta1 signaling pathway in hepatocellular carcinoma., beta-1,4-Galactosyltransferase III suppresses beta1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer., beta1 integrin expression represents a reliable prognostic factor regarding the grading of liver metastases of colorectal cancer, Integrin alpha3beta1 mediates regulation of COX2 mRNA stability in human breast cancer cells., ITGB1 enhances epithelial-mesenchymal transition via FAK-AKT signaling pathways., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, In high grade malignant tumors (G1), CDH1 and ITGB1 gene expression was the highest, in G2 and G3 tumors the expression of both genes was gradually lowering, mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the b1-integrin/ILK pathway., Data indicate that miR-134 suppressed the invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134., Low integrin beta 1 is associated with migration and invasion of colorectal cancer., Suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in airway epuithelial cells., Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive., Results indicate that the signaling critical to epithelial-to-mesenchymal transition (EMT) is regulated by the beta6 integrin cytoplasmic domain., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., beta1 integrin participates in calreticulin (CRT)-mediated cell adhesion in J82 human bladder cancer cells., These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways., VCAM-1/VLA-4-dependent activation of NF-kappaB has a role in mediating chemoresistance in leukemia cells, the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety, Data suggest that TIMP1 (tissue inhibitor of metalloproteinase-1) acts as chemoattractant for neural stem cells (NSC); TIMP1 enhances NSC adhesion, migration, and cytoskeletal reorganization; these effects are dependent on CD29/CD63 (granulophysin)., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation., the expression of integrin beta1 protein in cervical SCC tissues was significantly higher than that in the normal cervical tissues, and it increased with the clinical stage and the degree of malignancy., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, a Rap1A/beta1 integrin pathway, activated downstream of G-protein-coupled receptor stimulation and RhoA, in glioblastoma cell proliferation., phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that increases metastatic potential of prostate cancer cells., Results suggest that ITGB1 regulates the growth and apoptosis of human colorectal cancer cells., circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells., It plays a role in regulation of leukocyte migration to a site of inflammation., These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells., ITGB1 upregulation is involved in tumorigenesis and disease exacerbation by inflammatory cytokines as IL-6, TGF-beta1 and SDF-1, and targeting ITGB1 and the inflammatory modulator is a strategy for therapeutic intervention of ovarian carcinogenesis., abundance of LMTK3 positively correlated with that of the integrin beta1 subunit in breast cancer patient's tumors, Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543, When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., diabetic retinopathy is associated with ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension., C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity., Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 protein levels in prostate cancer cells, and increased lethality., lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier, Integrin beta1 and VEGF are overexpressed and microvascular density is increased in hypopharyngeal squamous cell carcinomas., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1., indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Data show that fluvastatin (FLV) attenuated the podocyte injury induced by puromycin aminonucleoside (PAN) and increased the production of beta1 integrin in podocytes., Data indicate that the interaction between S100A6 and integrin beta1, was confirmed by ELISA., Low NAMPT is associated with upregulation of beta1-integrin in breast tumor cells., The stimulatory cues of matrix rigidity were driven by b1 integrin mechano-sensing through FAK (pY397), and were associated with a posttranscriptionally driven rise in b1 integrin expression, This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway, CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility., our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling, The carbon monoxide signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand., Baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways., we demonstrate that beta1 integrins have a pivotal role in breast cancer bone colonization using unique tissue-engineered humanized bone models., The cytoplasmic tail of human integrin beta-1 contributes to fibroblast cell adhesion forces., role in stretch-induced renal fibrosis through the activation of c-Src and STAT3 signaling pathways, it is not just inactivation of Fyn that promotes multicellular spheroid formation but this must be coupled with the full length beta6 integrin., integrin alpha8beta1 has a protective role in arterial remodelling and atherosclerosis, These data provide evidence for CD147 as an important determinant of radioresistance via the regulation of integrin beta1 signaling., PCTK1-KAP0-myosin X-integrin beta 1 is a functional module providing a link between ECM and the actin cytoskeleton in the cell-extracellular matrix (ECM)-dependent control of spindle orientation., Data suggest expression of B4GALT3 in placenta is up-regulated in third trimester; overexpression of B4GALT3 suppresses trophoblast migration and enhances glycosylation of ITGB1; stability of ITGB1 may regulate trophoblast invasion in late pregnancy., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts., Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway., a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, an 'in solution' steady state organic fluorophore based quantitative fluorescence resonance energy transfer (FRET) assay to quantify VLA-4/VCAM-1 interaction., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway., DPP-4 and integrin beta1 interactions regulate key endothelial cell signal transduction in both physiological and pathological conditions including endothelial mesenchymal transformation., Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis., Hyperhomocysteinemia reduces BM CD34(+)/VEGFR2(+) generation and suppresses CD34(+)/VEGFR2(+) cell mobilization and homing to the injured vessel via beta1-integrin inhibition, which contributes to impaired re-endothelialization and vascular remodeling., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., ITGB1 SNPs might be a prognostic biomarker for CRC., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., the association between two genetic polymorphisms located in the VLA4 gene and the risk of multiple sclerosis, was investigated., HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion., CD105 and CD29 immunoexpression in decidua basalis, fetal membrane and placental villi showed significant negative correlations with the maternal age, This paper finds a regulatory role for beta1 integrins in the repair of radiogenic DNA damage via classical non-homologous end joining., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-related biological processes, Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship, We propose that PrP modulates beta1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin, and through the regulation of ERM-mediated membrane-cytoskeleton linkage., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma., based on the interaction motifs in Sdc1 and Sdc4, called synstatins (SSTN210-240 and SSTN87-131) competitively displace the receptor tyrosine kinase and alpha3beta1 integrin from the syndecan with an IC50 of 100-300 nm, Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility., HPW-RX40 restores the anoikis sensitivity in the metastatic breast cancer cells by inhibiting integrin beta1 and subsequent FAK activation., blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow, CXCL12/CXCR4 activation by cancer-associated fibroblasts mediated integrin beta1 clustering at the cell surface and promoted the invasive ability of gastric cancer cells, the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion., Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration., Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes., Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling., establish a paradigm according to which retrograde trafficking, and not endosomal recycling, is the key driver for beta1 integrin function in highly polarized cells, These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane., knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased, Inhibition of integrin beta1 activation on the cortex and disruption of its asymmetric distribution leads to spindle misorientation., G-CSF stimulates beta1 integrin expression and Swan 71 cell migration by activating PI3K and MAPK signaling pathways., GM2 mediats tumor cell migration by interacting with ITGB1 leading to downstream signaling and the phosphorylation of ERK MAP kinases.,
OFFICIAL_GENE_SYMBOL ITGB1,
SP_COMMENT function:Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis., online information:CD29 entry, PTM:The cysteine residues are involved in intrachain disulfide bonds., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subcellular location:Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells., subunit:Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with RAB21., tissue specificity:Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).,
syndecan 4(SDC4) syndecan 4(SDC4) Related Genes Homo sapiens
CHROMOSOME 20,
CYTOBAND 20q12,
ENSEMBL_GENE_ID ENSG00000124145,
GENERIF_SUMMARY Studies suggest that antithrombin regulates neutrophil migration via effects of its heparin-binding site on cell surface syndecan-4., Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes, Clustering induces redistribution of syndecan-4 core protein into raft membrane domains, Syndecan-4 core protein mediates the effects of fibroblast growth factor (FGF)2 on cell function. PKCalpha activation and PDZ-mediated formation of a serine/threonine phosphatase-containing complex by syndecan-4 are downstream events of FGF2 signaling., SDC4 regulates inositol phospholipid binding and signaling, the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner, Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA, endotoxin-induced adhesion of leukocytes to endothelium can be reversed by ligation of syndecan-4 with antithrombin's heparin-binding site, syndecan-4/CXCR4 complex is likely a functional unit involved in SDF-1 binding, human trabecular meshwork cells express only syndecan-1, and not syndecan-4, at the cell surface, and focal adhesion and stress fiber formation occur independent of syndecan-4, Syndecan-4 has a critical role in thrombin-induced migration and proliferation in human vascular smooth muscle cells, CXCL12 directly binds to syndecan-4 in a glycosaminoglycan-dependent manner, may play important roles in the regulation of inflammatory effects of platelets, Plasmin and thrombin accelerate shedding of syndecan-4 ectodomain, which generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds, the transmembrane domains are sufficient for inducing dimerization and transmembrane domain-induced oligomerization is crucial for syndecan-2 and syndecan-4 functions, The H. pylori- and TLR-induced increase in syndecan-4 mRNA was blocked by the proteosome inhibitor MG-132 suggesting a role for nuclear factor kappaB (NF-kappaB) in the regulation of syndecan-4 gene expression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, Stress-induced effects on smooth muscle cell syndecan-4 expression and shedding may represent an additional component of proinflammatory, growth-stimulating pathways activated in response to changes in the mechanical microenvironment of the vascular wall., The expression of syndecan-4 protein was significantly enhanced by TNF-alpha in HUVECs., An alternate pathway mediated by the extracellular domains of syndecans-2 and -4 is characterized that is independent of both heparan sulphate and syndecan signaling., These results identify syndecan-4 as a novel receptor for the N-terminus of TSP-1 and suggest that TSP-1 N-terminal pro-angiogenic activity is linked to its capacity of interfering with syndecan-4 functions in the course of cell adhesion., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, syndecan-4 is a critical intrinsic regulator of inflammatory reactions via its effects on OPN function, This study provides evidence for the up-regulation of syndecan-2 and -4 in human primary CD4 T cells during in vitro activation and suggest an inhibitory role for these syndecans in CD4 T cells., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, None of the SDC4 polymorphisms showed a difference in their allelic distribution between leg ulcer patients and controls. SDC4 may play a role in wound healing, but expression abnormalities in uninvolved dermis may contribute to venous ulcer development., ADAMTS1, involved in angiogenesis and inflammatory processes, cleaves the ectodomain of syndecan-4. This cleavage results in altered distribution of cytoskeleton components, functional loss of adhesion, and gain of migratory capacities., SD-4 is the T-cell ligand of DC-HIL., The present study shows that highly pathogenic H. pylori strains induce syndecan-4 expression, both in human gastric mucosa and in gastric cell lines, in a cag pathogenicity island-dependent manner., Syndecan-4 may be a sensor of tension exerted on the matrix [review], Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan-4 is specifically induced in type X collagen-producing chondrocytes in osteoarthritis, The down-regulation of syndecan-4, a heparan sulfate proteoglycan, decreased SDF-1/CXCL12-mediated HeLa cell invasion., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Study identified an overrepresentation of focal amplifications of known (FGFR3, CCND1, MYC, MDM2) and novel candidate genes (MYBL2, YWHAB and SDC4) in stage Ta bladder carcinoma., Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., SDC4 promotes cytokinesis in a phosphorylation-dependent manner in MCF-7 breast adenocarcinoma cells. The serine179-phosphorylation and the ectodomain shedding of SDC4 changed periodically in a cell cycle-dependent way., Expression of syndecan 4 in healthy human breast tissue during menstrual cycle., In dendritic cells, lysophosphatidylcholine-induced phosphorylation of SDC4 by PKCdelta results in a functional inactivation of SDC4 and decreases adhesion and motility., Data found that Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4., RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling., syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides., SD-4 bearing distinct heparan sulfate moieties plays a pathogenic role in Sezary syndrome and may be targeted for treatment., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production., in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5., Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway, By accruing more syndecan-4 on their surface and also shedding it during Th1 cytokine-driven inflammation, asthmatic airway smooth muscle cells may regulate inflammation and remodeling locally and alter the responsiveness of the airways in asthma., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., studies identify S4 as a regulator of MAPK signaling and address the question of how distinct classes of FGFRs individually contribute to signal transduction in endothelial cells, Syndecan-4 expression and shedding were increased in failing human myocardium., EGFR are the key mediators of SDC-4 expression in MCF-7 cells., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, PGE2-induced activation of angiogenesis is mediated via syndecan-4-dependent activation of PKCalpha., NF-kappaB p65 could be a key mediator of syndecan-4 upregulation by TNF-alpha through two binding sites in the SDC4 promoter, but other NF-kappaB-p65 independent pathways might also be involved through transcriptional elongation., syndecan-4 is differentially expressed in seminomas and nonseminomatous germ cell tumours and might be a useful marker., The more upgraded the NYHA grading, the higher level of serum syndecan-4 protein., in healthy discs, SDC4, through its heparan sulfate side chains, contributes to maintenance of the hypoxic tissue niche by controlling baseline expression of Sox9., The cytoplasmic V domain of syndecan-4 made a significant contribution to the cellular uptake of octaarginine, whereas the cytoplasmic C1 and C2 domains were not involved in the process., High glucose modifies TRPC6 channels and ROS production via SDC-4 in human podocytes., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., syndecan 4 is the predominant heparan sulfate proteoglycan in the glomerular endothelial cells glycocalyx, Sdc4 is necessary for activation of the integrin during chemokinesis induced by EGF., Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium., No association was found with SDC4 and breast cancer., Data indicate that depletion of syndecan 4 (S4) in umbilical vein endothelial cells (HUVECs) using shRNA inhibited flow-induced alignment in vitro, which was rescued by re-expression of S4., Syndecan-4 polymorphisms were associated with essential hypertension, body mass index, and coronary artery disease prevalence in the Tampere adult population cardiovascular risk study., define a role for TG2 activity at the surface of human macrophages in multiple stages of AC clearance and we propose that TG2, in association with heparan sulphates may exert its effect on AC clearance via a mechanism involving the crosslinking of CD44, Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility., results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity., Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4,
SP_COMMENT function:Cell surface proteoglycan that bears heparan sulfate., function:Cell surface proteoglycan., similarity:Belongs to the syndecan proteoglycan family., subunit:Homodimer. Interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS (By similarity). Interacts with SDCBP., tissue specificity:Expressed in epithelial and fibroblastic cells.,