Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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DAVID Functional Annotation Table
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integrin subunit beta 1(ITGB1) integrin subunit beta 1(ITGB1) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10p11.2,
ENSEMBL_GENE_ID ENSG00000150093,
GENERIF_SUMMARY the linkage between beta1 integrin and actin may be differentially regulated by its tyrosine and serine/threonine phosphorylation in normal and cancerous breast cells., Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling, Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction, both VEGF-induced PI 3-kinase activation and beta(1) integrin-mediated binding to fibronectin are required for the recruitment and activation of PKC alpha., Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines., Although cytoplasmic splice variants do not change the ligand-specificity of a beta 1 integrin, this review explains how clustering of different splice variants triggers signaling pathways that lead to a different cellular response., beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican, These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells., Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, Data demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins such as CD151 are palmitoylated, and that palmitoylation is not required for cd151-alpha3beta1 integrin association., Activated Notch4 inhibits angiogenesis, role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding, mechanical stress to the beta1-integrin subunit in osteoblasts revealed that cyclic forces of 1 Hz were more effective to stimulate the cellular calcium response than continuous load, beta1 and beta2 integrins activate different signalling pathways in monocytes., Inv-induced cell death was mediated via beta1-integrins since Inv bound to the beta1-integrin subunit (CD29), anti-beta(1)-integrin antibodies blocked Inv-induced cell death and Inv-induced cell death was absent in two beta1-integrin- cell lines., Beta1 integrin triggering affects leukemic cell line sensitivity to natural killer cells, Evidence for distinctive signaling of CD82- and beta1 integrin-mediated costimulation at the transcriptional level of IL-2 gene., There is a desensitization of IL-8-mediated p42/p44 MAPK signaling in response to ligation of the alpha5beta1 integrin in PMNL. There may be an interplay between integrin and chemokine signaling during PMNL migration through the extracellular matrix., Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines, Ionizing radiation strongly induced the expression of functional beta1-integrin and ILK in the two lung cancer cell lines, A549 and SKMES1., mediates adhesion of osteosarcoma to the core region of thrombospondin 1 (alpha 4 beta 1 integrin), role in regulating beta 1 integrin-dependent leukocyte adhesion, results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, VLA4 integrin activation by chemokines requires cholesterol, role of Rap1 GTPase for Mn(2+)- and antibody-induced VLA-4-mediated cell adhesion [VLA-4], Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., Data show that, in vitro, under physiological conditions, CD98 is constitutively associated with beta1 integrins regardless of activation status., Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, data suggest that overexpression of beta 1-integrin confers resistance to apoptosis in hepatoma cells via a MAP kinase dependent pathway, regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47, role in mediating pro-angiogenic activity of CYR61, beta1 integrin engagement is required for bombesin-dependent pro-MMP-9 activation in prostatic cancer cells, initial adhesion of endometrial cells to mesothelium is not mediated by beta1 integrins but attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins, molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes, findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought, Temporal gene expression profile of precursor B leukemia cells induced by ITGB1 identifies pathways regulating B-cell survival., results are consistent with an essential role for beta(1) integrins in maintenance of cardiomyocyte viability and interaction with extracellular matrix, Data show that the expression of the PAINS-13 epitope depends on CD9 association with alpha(6)beta(1) integrin., Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., beta1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by its gC1q domain, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1, integrin beta1 cytoplasmic peptides self-associate; role in beta1 integrin clustering and formation of focal adhesions, beta(1) integrin has a role in the syndecan-4 pathway for cell spreading, along with PKCalpha and RhoA, Overexpression of AKT2/protein kinase Bbeta leads to up-regulation, increased invasion, and metastasis of human breast and ovarian cancer cells., that the expression of beta(1C) integrin, a very efficient inhibitor of cell proliferation, may be modulated by the maternal microenvironment and may play a fundamental role in mediating trophoblast outgrowth and migration during pregnancy., Results establish, for the first time, mutation as a mechanism by which integrins can contribute to neoplasia., Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, beta1 integrin has a role in selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, determination of crystal structure in complex with an antibody Fab fragment, Data show that NADPH oxidase activation production of reactive oxygen species are involved in the increase of alpha2beta1-integrin plasma membrane expression in Caco-2 cells stimulated with type IV collagen., endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., expression of beta1 integrin subunit is responsible for differentiation-associated changes in cells behavior in terminally differentiated oral keratinocytes, capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation., adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated in platelets, identification of binding site in gamma C-domain of fibrinogen, Decidual beta1 integrin and FAK participate in this final step of implantation., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alpha 6 beta 1 binds to CCN1, Alpha4beta1 integrin has a role in cell adhesion, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, cells overexpressing beta 1-integrin exhibited increased proliferation in response to hepatocyte growth factor., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., identify intracellular signals involved in integrin BETA1-initiated internalization of S. aureus, in beta-thalassemic patients, significant reduction of CD49d, CD29 and CD71 antigen expression was found in peripheral blood nucleated red cells, upon treatment with phorbol esters, K562 cells become adherent and permissive for parvovirus B19 entry, which is mediated by alpha 5 beta 1 integrins, but only in their high-affinity conformation, alpha6beta1 integrins have roles as thrombospondin receptors in microvascular and large vessel endothelial cells, Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit., S-phase delay induced by overexpression of integrin beta1 subunit caused by decrease of protein kinase B phosphorylation and subsequent increases of p21(cip1) and p27(kip1) proteins. May be involved in unoccupied alpha5beta1 because of lack of ligands., Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin., In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels., The beta1-integrin-ligand disengagement resulted in capillary disruption and stimulated p38 MAPK and extracellular signal-regulated kinase activity., beta1 integrin/FAK-mediated signaling on osteoblasts could be involved in ICAM-1- and RANKL-dependent osteoclast maturation, results suggest that beta1 integrin is a common receptor for AfaD invasins and that additional AfaD-type-specific receptors exist, The structural conformation of this protein, complexed wigh integrin alpha5, complexed with fibronectin, is examined, Reduced beta1 integrin-mediated cell adhesion of HME cells to the substratum during mitosis may be induced by beta1 integrin phosphorylation at threonines 788-789 and its reduced ability to link with the actin cytoskeleton., role in ganglioside GM3 blocking of epidermal growth factor receptor, following priming of human neutrophils with lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha), addition of formyl-Met-Leu-Phe (fMLP) results in a "stimulated", sepsis-like, four- to fivefold rise in CD49d expression, the failure of beta1 integrin dephosphorylation at threonines 788 and 789 may be due to a significant reduction in the PP2A-A expression in tumor cells, integrin beta1 interacts with galectin 1, Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin., human platelet deposition on collagen depends on the concerted interplay of several receptors, Data demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of putative pancreatic progenitors on Netrin-1., ligand-binding specificities of integrin alpha3beta1 and alpha6beta1, Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., alpha3beta1 integrin binding to laminin-5 depends on its proteolytic processing, beta1C integrin splice variant is transcriptionally regulated in human prostate adenocarcinoma, integrin alpha4beta1 is induced by p53 and has a role in B-cell chronic lymphocytic leukemia drug resistance, Key role of the regulation of beta 1C integrin expression in the pathogenesis of endometrial proliferative diseases, results suggest that a direct interaction occurs between the Adenovirus penton base protein and the integrin receptor alpha3beta1 in vitro and in vivo, results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes, alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, Data show that stimulation-dependent recycling of integrin beta1 is regulated by ARF6 and Rab11, and also requires the actin cytoskeleton in an ARF6-dependent manner., results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling, Alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis., beta1 integrin maturation and transport to the cell surface is regulated by low density lipoprotein receptor-related protein-1, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta I-like and alpha I domain activation involves structurally analogous alpha7-helix axial displacements., beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis., EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions, findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells, Overexpression of integrin beta(1)modifies the response of I(Ca)to beta-adrenergic receptor stimulation., conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation, very late antigen-4 affinity is modulated by shear, alpha2beta1 integrin has a role in endorepellin-induced endothelial cell disassembly of actin cytoskeleton and focal adhesions, role in chemotaxis in conjuction with plasmin, Increases in IGF-IR decrease beta1 integrin expression, and enhance cell migration in neuroblastoma cells., alpha2beta1 integrin and GPVI regulate stress fiber formation in megakarocytes, the primary actin structures needed for cell contraction, Calu-1 lung cancer cells use primarily a beta1-integrin-mediated intracellular tyrosine phosphorylation phenomenon as the key regulatory mechanism for its binding advantage to Coll IV matrix., alpha 3 beta 1 integrin is necessary and sufficient for maximal keratinocyte survival on laminin-5, alpha4beta1 integrin on sickle reticulocytes is a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides., cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin, ILK regulates alpha 2 beta 1 in HEL cells, is activated in platelets and associates with beta 1-integrins, integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., 16K expression inhibits beta(1) integrin surface expression and spreading on matrix by a novel mechanism that results in reduced levels of functional beta(1) integrin, alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis, The integrin, beta 1 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes, Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., Activation of PI3K following beta1-integrin engagement on human CD34+ cells results in subsequent phosphorylation of PYK2, and is required for the recruitment of the PI3K/PYK2 complex to beta1-integrins at the cell surface., Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of hepatocellular carcinoma cells to laminin., demonstrates a cooperative role between alpha5beta1 and alpha4beta1 integrins and suggests that interactions between the Hep II domain and alpha4beta1 integrin could modulate the strength of cytoskeleton-mediated processes in the trabecular meshwork, ICAM-1 molecules interacted only with group B Streptococcus(GBS)-III liquor 90356 strain while beta1 integrin interacted with GBS-III liquor 90356 and GBS-V blood 90186 invasive strains, VEGF-C and VEGF-D are ligands for the integrin alpha9beta1, The expressive fluorescent intensity of integrinbeta(1) in G(1) phase SMMC-7721 cells was depressed more significantly than the values of S phase., analysis of transcriptional regulation of beta1 integrin expression in endometrium and endometrial neoplasms, Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Results indicate that CD151 association modulates the ligand-binding activity of integrin alpha3beta1 through stabilizing its activated conformation not only with purified proteins but also in a physiological context., JAM1 regulates epithelial cell morphology and beta1 integrin expression by modulating activity of the small GTPase Rap1., Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., integrin beta1 function is modulated by CD98 in polarized epithelial cells, VEGF and alpha4beta1 integrin have roles in chemokine-induced motility on and through endothelium in chronic lymphocytic leukemia cells but not in normal B lymphocytes, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, Interacts with vimentin, but this association is lost after prolonged adhesion of endothelial cells to collagen., Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation., Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway, activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion, KSHV gB can activate VEGFR-3 on the microvascular endothelium and modulate endothelial cell migration and proliferation via an interaction between the alpha3beta1 integrin and the VEGFR-3 receptor, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, matrix-derived mechanical forces sensed by beta1 integrin are capable of modulating ILK activity which regulates fibroblast viability via an Akt-dependent mechanism, alpha3beta1 integrin binding results in a suppression of the interleukin-1 signaling pathway leading to the activation of NF-(kappa)B, alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density, FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, analysis of platelet glycoprotein I(b)alpha and integrin alpha2beta1 polymorphisms in diverse populations, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, Expression pattern of integrin subunits in the human fetal pancreas (8-20 weeks fetal age) and the relevance of beta1 integrin function for insulin gene expression and islet cell survival., PDGFR-dependent cell detachment is induced by S1P via inhibition of beta1 integrin in HEK293 cells, Three intracytoplasmic motifs of the tail of VLA-4 beta 1 subunit differentially regulate VLA-4-mediated adhesive functions under static adhesion and shear flow conditions., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1, the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, phenotypic conversion and reversion of bladder cancer cells is controlled by a glycosynapse 3 microdomain through GM3-mediated interaction of alpha3beta1 integrin with CD9, Results provide evidence for a novel species of beta1 integrin on the cell surface, which does not appear to be associated with any alpha chain., alpha2beta1 and signaling via autocrine mediators facilitate and amplify the GPVI procoagulant activity of fibrillar and non-fibrillar collagens, IFN-gamma attenuates epithelial wound closure by microtubule-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of focal adhesion complexes and cell migration., mapping of the N-glycosylation sites on the beta1 integrin to better understand the potential effects of differential sialylation on integrin structure/function, The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells., Cells deficient in beta1 integrin can bind human ADAM12 via beta3 integrin., the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia, suggests beta1-integrins as critical regulators of cell survival after radiation-induced genotoxic injury, beta 1 integrin has roles in cell adhesion and migration in development and metastasis [review], beta1 integrin is critical for the alveolar morphogenesis of a glandular epithelium and for maintenance of its differentiated function, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, isolated beta1 cytoplasmic domain expression induces caspase-independent detachment of viable endothelial cells and that death is secondary to detachment (i.e. anoikis), Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain, Our data show that alpha3beta1 integrin function may be altered by glycosylation, that both subunits contribute to these changes, and glycosylation may be considered a newly found mechanism in the regulation of integrin function., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., Platelets, by binding via P-selectin to PSGL-1 on monocytes, induce up-regulation and activation of beta1 and beta2integrins and increased adhesion of monocytes to activated endothelium., The Integrin beta1 thrombogenic polymorphism and FcgammaRIIA expression could play a role in platelet sensitivity to collagen in type 2 diabetes., The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., decreased podocyte expression of alpha3beta1 integrins is closely related with podocyte depletion, glomerular sclerosis, and daily protein loss in patients with primary focal glomerulosclerosis, facilitates reovirus internalization and suggest that viral entry occurs by interactions of reovirus virions with independent attachment and entry receptors on the cell surface., IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., This study supports matrix-induced clustering of alpha3beta1 integrin promotes uPAR/alpha3beta1 interaction; potentiating cellular signal transduction pathways culminating in activation of uPA expression and enhanced uPA-dependent invasive behavior., EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization, urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, Beta1-integrin subunit is identified as a new gastrin-regulated gene in human pancreatic cancer cells., Data indicate that integrin beta1 plays a major and complex role in osteoblastic differentiation modulated by either surface microarchitecture or 1alpha,25(OH)2D3., RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR., Slug regulates integrin alpha3, beta1, and beta4 expression and cell proliferation in human epidermal keratinocytes, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, Data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells., These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells., Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer., The formation of dendrites is shown to require the interaction between the beta1-integrin (CD29) on the surface of the DCs and fibronectin in the extracellular matrix., Data show that the integrin beta1 repertoire in renal cell carcinoma is different from normal proximal tubule cells, and that valproic acid acts on all investigated integrin subtypes to restore the receptor pattern typical for non-malignant cells., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, This is the first demonstration that the integrin beta1 tail can regulate centrosome function, the assembly of the mitotic spindle, and cytokinesis., Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies., Salivary progenitor epithelial cell survival is beta 1 integrin-dependent., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, Results show that alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells., results indicate that exported alpha-toxin inhibits the adhesion and internalization of S. aureus by interfering with integrin-mediated pathogen-host cell interactions., integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, comparison of DOCK2 and Vav1 involvement in CXCL12-promoted Rac activation and alpha4beta1-dependent human T cell adhesion indicated a more prominent role of Vav1 than DOCK2, IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry, Primary human mesenchymal stem cells are able to induce self-renewing divisions of hematopoietic progenitor cellsby a beta(1)-integrin-dependent mechanism., Results show that coculture with ECs enhances VSMC adhesion and spreading by up-regulating beta(1)-integrin expression and activating the PI3K/Akt pathway. Interaction between ECs and VSMCs serves a role in vascular homeostasis and remodeling., decrease of beta(1)D-integrin & FAK in ischemic cardiomyopathy; loss of beta(1)Dintegrin-FAK-complex in ICM paralleled by reduced AKT activity supporting in vitro data showing role of intact integrin function in anti-apoptotic signaling & cell survival, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, IL4-induced FBGC are characterized by the expression of alphaMbeta2, alphaXbeta2, alpha5beta1, alphaVbeta1, alpha2beta1, and alpha3beta1, which indicates potential interactions with fragments of C3, fibrin(ogen), fibronectin, Factor X, and vitronectin, alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells, Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner., The integrin activation level, assessed by binding of soluble collagen to the alpha2beta1 integrin, was reduced upon cell treatment with DT. The TS2/16, an anti-beta1 activating monoclonal antibody was able to rescue DT-treated cells from apoptosis., High affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells., These experiments identify a new compound that can interfere with biological processes by inhibiting microdomain formation and also identify beta1 integrin as a potential mediator of signaling by GSLs., Lubrol-RAFTs probably represent the platform for tumor-promoting ephrin-B2-integrin-beta1 interaction, which could become an interesting target for future antitumoral therapies, integrin beta1 has a role in inhibiting cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway, both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, These results suggest that engagement of beta1 integrins on systemic lupus erythematosus T cells could induce FAK-mediated signaling and subsequent CD40L expression and proliferation., These results indicate that binding of the alpha3beta1 integrin results in a suppression in the activation of the IL-1 induced intracellular signaling pathway from JNK to AP-1., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest an important role of integrin alpha2beta1, alpha3beta1, and alpha5beta1 in the architectural characteristics of ameloblastomas and adenomatoid odentogenic tumor, In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression., Data show that in bullous pemphigoid, expression of beta1 was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., This study identifies alpha2 beta1 integrin as an important regulatory pathway of IFN-gamma expression and provides novel insights into the signaling mechanisms of integrin costimulation in T cells., The VCAM-1/very late activation antigen 4 adhesive system critically mediates endothelial progenitor cell adhesion to cultured rheumatoid arthritis fibroblasts and to rheumatoid arthritis synovial tissue, LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, support a model in which KAI1/CD82 attenuates the maturation of the beta1 integrin precursor and thereby suppresses cell migration, T-cadherin may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in squamous cell carcinoma by regulating surface level of beta1 integrin, talin 1 is a versatile VLA-4 affinity regulator implicated in both spontaneous and chemokine-triggered rapid adhesions to VCAM-1., results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment, No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy., Beta1 and alpha3 integrins are functionally important receptors for type 1 pili-expressing bacteria within the urinary tract and possibly at other sites within the host., CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells, Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation., CXCR4 contributes to renal carcinoma cells (RCC) dissemination and may provide a novel link between CXCL12 expression and integrin beta1 triggered RCC adhesion to the vascular wall and subendothelial matrix components, Np-1 confers a growth and survival advantage to pancreas cancer cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness., The process of dynamic integrin regulation may be an important part in tumour cell migration strategy, switching the cells from being adhesive to becoming motile and invasive., identification of alpha3beta1 as the predominant integrin and laminin receptor in glioma cells, and as a brain invasion-mediating integrin, IGF-I receptor and beta1-integrin signaling may play an important role in protective effect of hyaluronic acid on interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, TGF-beta2 promoted human lens epithelial cell adhesion and migration in vitro. Integrin beta1 and integrin-mediated signaling are necessary for TGF-beta2-promoted adhesion and migration in human lens epithelial cells., The expression of beta1-integrin was found to be significantly reduced in photoaged skin and ratios of the expressions of involucrin to beta1-integrin were increased 2.6-fold only in elderly subjects., These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal., These results strongly suggest that enhanced expression of alpha3beta1 integrin on hepatocellular carcinoma cells is directly involved in their malignant phenotypes such as invasion and metastasis., The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an extracellular matrix-dependent and integrin-mediated manner., These data demonstrate that activation of Epac1 increases integrin activity and integrin-dependent homing functions of progenitor cells., tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation., results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion, Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells., Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins., The physiologically relevant organ culture assay employed here is a potential research tool for exploring whether targeted stimulation of beta1 integrin-mediated signalling is a suitable candidate for human hair loss management., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin., Integrin beta1 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., Integrin beta 1 transgene is involved in the phagocytosis of certain bacteria, including group B streptococcus and Staphylococcus aureus, and critically regulates phagosome maturation through Rac expression., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., Beta1 integrin/Fak/Src signaling translates into integrated mediating functions of p38b activation and regulation of Bcl-2 homologs by PI3-K/Akt-1 and MEK/Erk, consequently determining their requirement (or not) for survival., B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44., H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin-JNK pathway, HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, Hypersialylated beta1 integrin is endogenously expressed in human astrocytoma cell lines., Show a critical role of PKCdelta in the regulation of renal carcinoma cell migration, which seems to be caused by affecting the expression and activity of beta1 integrins and focal adhesion kinase., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes, key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., The data suggest that phosphoenolpyruvate -dependent decrease of collagen biosynthesis in cultured human skin fibroblasts may undergo through depression of alpha(2)beta(1) integrin and IGF-IR signaling., CD151 regulates integrin alpha3beta1 functions in two independent aspects, TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation[review], Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients, study reports that T cell costimulation by the integrin VLA-4 (alpha4beta1) required SLP-76 domains implicated in microcluster assembly, Integrin alpha2beta1 may promote migration and invasion of neuroblastoma cells., Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., These results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of enterotoxin function and rotavirus pathogenesis, further distinguishing this viral virulence factor from other microbial enterotoxins., The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., LPS or peritoneal dialysis effluent stimulated the adherence of T cells to mesothelial cells, a process mediated by the integrins alpha6beta1 and alpha4beta1, Chemotherapy-induced overexpression of integrin b1 in some multiple myeloma patients upregulates LRP expression in bone marrow cells, inducing antineoplastic drug resistance., Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis ., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, gal-3 binds directly and preferentially to unsialylated, as compared with alpha2-6-sialylated, beta1 integrins, EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Results suggest that HAb18G/CD147 enhances the invasion and metastatic potentials of human hepatoma cells via integrin alpha3beta1-mediated FAK-paxillin and FAKPI3K-Ca(2+) signal pathways., Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., The mRNA levels of integrin beta1 and ILK protein were significantly higher in laryngeal carcinoma than in the surrounding tissue and vocal cord polyps., These data data suggest that, in migrating intestinal epithelial cells, beta(1)-integrin is internalized via a dynamin-dependent lipid raft-mediated pathway., Preferential downregulation of beta1-integrin expression on progenitor cells can reduce the tethering forces to BM components, thus facilitating their egress to the peripheral circulation during an allergic inflammatory response., SEMA3A suppression of tumor cell migration is dependent on alpha2beta1, the expression of which is stimulated in breast tumor cells by an autocrine SEMA3A pathway., tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges., analysis of distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens., These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The integrin beta1-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas., VLA-4, a heterodimer of CD49d and CD29, is the most important adhesion molecule for cell-adhesion-mediated drug resistance in multiple myeloma cells., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins, Our results argue for the involvement of galectin-1 in the PKCepsilon/vimentin-controlled trafficking of integrin-beta1, Overexpression of GluR1 positively correlated with glioma cell adhesion to type I and type IV collagen which was decreased in cells with blocking antibodies to beta1 integrin, NO targets activation-dependent adhesion mediated by alpha(2)beta(1), possibly by reducing bioavailability of platelet-derived ADP, but has no effect on activation-independent adhesion mediated by GPVI, analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1, The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789., overexpression of ITGB1 may be related to resistance to chemotherapy in esophageal squamous cell carcinoma, These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth., Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a "vicious cycle" between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction., Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state., Suggest that the specific interaction of MCT4 with beta(1)-integrin may regulate cell migration through modulation of focal adhesions., mechanisms by which TF induces estrogen receptor alpha expression in breast cancer involve both PAR2 and beta(1)-integrin, Integrin-beta1 was overexpressed in oral leukoplakia, and may correlate to the proliferation of the dysplasia cells., TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., Functional live-cell imaging demonstrates that ITGB1 promotes type IV collagen degradation by breast and prostate cancer cells., alpha 3, alpha 6A, and beta 1 integrin expression in cancer cells at the invasive front are related to the mode of invasion and prognosis in oral squamous cell carcinoma, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Results suggest that prostaglandin E2 mainly induces the activation of beta(1)-integrins via the EP(2) receptor in human coronary arterial endothelial cells., Stress application to activated beta1 integrins increases Galphas recruitment and activates these large G proteins within focal adhesions, JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration., findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, Expression of a genetic variant in the I-like domain of beta1 integrins does not affect normal epidermal homeostasis, but increases skin tumor susceptibility and influences tumor type in transgenice mice., High levels of VLA-4 is associated with mantle cell lymphoma., Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects, These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function, This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp., Cdc42 activity is impaired in beta1 integrin-deficient T cells that form conjugates with antigen-presenting cells but is partially restored in the context of an antigen-specific synapse., Data showed that tumor-associated matrices induced PI3K and beta1-integrin dependent Akt/PKB activity in MDA-MB-231 cells., These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence., Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN., Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin., TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling., alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization, Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, Compared with open surgery, laparoscopy-assisted radical gastrectomy is not associated with a greater effect on the expression of ICAM-1 and integrin beta(1) in peritoneal mesothelial cells., These findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, These findings support a role for FLNa-beta1 integrin as a mechanosensitive complex that bidirectionally senses the tension of the matrix and, in turn, regulates cellular contractility and response to this matrix tension., decreased expression on allograft T cells of healthy bone marrow donors following Granulocyte colony-stimulating factor pretransplant conditioning, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, The presence of the alpha11 integrin chain during early corneal development and the enhanced expression in scarred keratoconus corneas indicates that integrin chain is likely to play an important role in collagen deposition during corneal development, In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., these results highlight for the first time the considerable role of the integrin alpha6beta1 in glioma progression., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche, Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., A GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation., is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1], Interactions between type I collagen and beta1 integrins augment apoB secretion by Caco-2 cells., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes, a central role for alpha2beta1 integrin in experimental and developmental angiogenesis, upregulated expression in lung adenocarcinoma cells following bacterial infection, Musashi-1 and beta1-integrin may be involved in human colorectal tumor carcinogenesis and progression., ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway., AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression., Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations., new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., Among laminin-binding integrins, mast cells express alpha3beta1 (but not alpha6beta1, alpha7beta1, or alpha6beta4) integrins., Gal-3 promotes epithelial cell migration by cross-linking MGAT5-modified complex N-glycans on alpha3beta1 integrin., Integrins alpha3beta1 and alpha6beta1 are important cell surface receptors that mediate the chemotaxis of hepatocelluar carcinoma cells toward laminin., Integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 to mediate tumor invasion and metastatic processes., Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP, ERbeta affects integrin expression and clustering and consequently modulates adhesion and migration of breast cancer cells., although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Detecting intracellular Erk1/2 phosphorylation and IL-2 and IFN-g production, study confirmed that multiple signals, including VLA-4 engagement, are necessary for maximal T-cell activation beyond that induced via the TCR and CD28., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads., Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., beta(1)-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients, Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., in its entry strategy human echovirus 1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor, results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Targeting of integrin beta1 and kinesin 2alpha by microRNA 183., Induced integrin alpha5 and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest., Collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and this effect is mediated by the interaction of collagen with integrin alpha2beta1., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., These results suggest that both gangliosides and beta1-integrin are required for maintenance of caveolae and plasma membrane domains., conserved NPXY and TT motifs play important roles in the tissue-specific function of integrin, Data suggest that integrin alpha(2)beta(1), glycoprotein Ib and vWf interactions with collagen I and III contribute to platelet adhesion under high shear flow., DSCs-expressed CD82 up-regulates the expression of TIMP1 in an autocrine manner and inhibits the invasiveness of human first-trimester trophoblast cells partly through the integrinbeta1/MAPK/MAPK3/1 signaling pathway, Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1., Increased uPAR expression promotes alpha(3)beta(1) integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors., the binding of filamin A to vimentin and protein kinase C epsilon is an essential regulatory step for the trafficking and activation of beta1 integrins and cell spreading on collagen, Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Data show that the L-plastin/integrin complex is regulated by mu-calpain cleavage and is not directly dissociated by calcium., Integrins may initiate the cellular response of osteocytes to dynamic fluid flow and may serve as mechanosensitive molecules in bone., The results demonstrate definitely that major quaternary rearrangements of beta1-integrin subunits occur in adherent cells and that conversion from a bent to extended form takes place at focal adhesions., Pancreatic beta cell mesenchymal transition and decline in insulin gene expression are induced by elements of the ECM, by b1-integrin ligation, and by signaling via Src, JNK, and ERK., The expression of Integrin beta1 decreases when the differentiation level of squamous cell carcinoma cells increase., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., Indicate that the integrin beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures., Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function., Inhibition of integrin beta1 reduced the adhesion forces of trophoblast cells to type I rat collagen or endothelial cells., Measurement of thrombus height after specific receptor blockade or use of altered proportions of peptides indicates a signaling rather than adhesive role for glycoprotein VI, and primarily adhesive roles for both alpha(2)beta(1) and the VWF axis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, The results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix., Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways., alpha4beta1-mediated tumor lymphangiogenesis promotes metastasis, Activation of ss1-integrin in human umbiilical vein endothelial cells (HUVEC) is specifically affected by depletion of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)., The authors identify beta(1) integrin, which is expressed by naive B cells of distinct lymphoid origin and by memory B cells from nasal mucosa-associated lymphoid tissue, as a mediator of increased susceptibility to infection by Epstein-Barr virus., Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion., up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions, Integrin beta 1 may play an important role in the development of hepatic fibrosis, hepatic cirrhosis and hepatocellular carcinoma., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Prostate tissue-derived CD133+ cells exhibited a high level of expression of beta1 integrin, The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., Inhibition of beta1 integrin function rescued proliferation and cyclin E1 expression as well as c-Myc expression and Rb phosphorylation., when beta(1)A is unligated, beta(1)B is responsible for "integrin-mediated death" in human keratinocytes, Recombinant or microparticle-associated tissue factor stimulate endothelial cell proliferation through activation of the ERK 1/2 pathway, mediated through a novel mechanism requiring the interaction of exogenous TF with cell surface beta1-integrin., Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration., Eight different anti-integrin beta1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed., Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, decreasing beta1 chain causes alphavbeta3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity., Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis., The HCMV gB-DLD protein bound to fibroblasts in a specific, dose-dependent and saturable manner that required the expression of an intact beta1 integrin ectodomain., alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, Findings argue strongly that beta1-integrin can both potentiate CMG2-mediated endocytosis and serve independently as a low-affinity PA receptor., plays a key role in the pathogenesis of pustulosis Palmaris et Plantaris, Calcium regulates integrin beta1 activity and expression and cell migration of HaCaT cells., Inhibition of beta1 integrin expression by DNAzyme to beta1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro., The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration., our data indicate that CCR7 regulate cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck, SIRPalpha facilitates cross-talk between the prolactin receptor (PRLr) and beta1 integrin and provides a basis for extracellular matrix regulation of PRLr action in breast cancer., Data confirmed reduced CD9 expression in MDS CD34+ and bone marrow mononuclear cells., U937 macrophage responses to the TLR2 ligand, Pam3CSK4, are dependent upon integrin alpha3beta1., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., Data show that coculture of ALL cells with MSCs induced on the lymphoblast plasma membrane the expression of a signaling complex formed by hERG1, the beta(1)-integrin subunit, and the chemokine receptor CXCR4., Data suggest that up-regulation of integrin beta1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2., Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction., the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells, Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression., Both wild-type and internal tandem duplication (ITD)-FLT3 proteins co-immunoprecipitated with beta1 integrin and Pyk2 indicating the signal crosstalk between FLT3, beta1 integrin and Pyk2., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions., Structural diversity in integrin/talin interactions., alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival, ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, investigation of role of ITGB1 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors., Data show that interactions between beta1 integrin and ErbB4 occur in a spatiotemporally-regulated manner, and such interaction contributes to the integrin-dependent cell migration., Ameloblastoma cells proliferate and are differentiated by capturing perlecan differentially with alpha-dystroglycan and integrin beta1, respectively, expression of VLA-4 in PBMC of hemorrhagic fever with renal syndrome (HFRS) patients at different stages were higher than normal controls, except recovery stage; VLA-4 might play an important role in the immunopathological lesions of HFRS, These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways., High expression levels of CD151 and alpha6 promote invasiveness of HCC cells. Either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC., Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells., kindlin-2 promotes integrin b1 and b3 activation., expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection., The extra nuclear AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. Assembly of this ternary complex may control organ development and prostate cancer metastasis., Data suggest that integrin alpha6beta1 is an important cell surface receptor that mediates the adhesion of the SMMC-7721 hepatocellular carcinoma cell line to type IV collagen., stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream beta1 integrin function, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., High integrin beta 1 is associated with invasive lobular cancer in comparison with other breast tumor types., a novel mechanism by which beta1 integrin regulates matrix metalloproteinase-10 expression during lymphatic vessel remodeling, Significant to anoikis-related regulation, the delay in caspase-8 activation was accompanied by the maintenance of FAK Tyr397 phosphorylation, integrin beta1-associated FAK and a FAK/caspase-8 complex., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., P-selectin, on eosinophil-associated activated platelets or acquired from plasma or from prior interactions with endothelial cells/platelets, activates eosinophil beta1 integrin, stimulating eosinophil adhesion to VCAM-1 and move to the airway in asthma., a direct interaction between the Oca-family member NadA and human beta1 integrins., in endothelial cells, ligation of alpha2beta1 and alpha6beta1 integrins induces the Notch pathway, and we disclose a novel role of basement membrane proteins in the processes controlling tip vs stalk cell selection, results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy., HOXD1 plays a significant role in endothelial cells functions by regulating the expression of ITGB1., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8, Pancreatic stellate cells radioprotect pancreatic cancer cells through beta1-integrin signaling, The effect of SDF-1 on colorectal cancer cell signaling and urokinase-type plasminogen activator (uPA) expression is mediated by the CXCR4/beta1 integrin axis., maspin, uPAR, and beta1 integrin co-immunoprecipitate, suggesting a novel maspin-uPA-uPAR-beta1 integrin mega-complex that regulates mammary epithelial cell adhesion., these findings show that epithelial-mesenchymal transition and its down-regulated expression of E-cad circumvent breast cancer dormancy in part by facilitating beta1 integrin expression necessary for metastatic outgrowth., High serum ITGB1 is associated with gastric cancer., The results showed that overexpression of Id1 enhanced cell migration and increased beta1-integrin expression, In osteoblasts exposed to dexamethasone, ILK expression was slightly increased, whereas there was substantial reduction in that of beta1 integrin., Both DCC and integrin bindings interfere with microtubule binding to myosin X., Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1., data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88, Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces., Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., beta1 integrin-mediated adhesion is upregulated during T lymphocyte extravasation by activating Galpha subunit-dependent inside-out signaling., MSC migration is controlled by CD73 & CD29, which in turn are regulated by mechanical stimulation of cells, elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins., when lung fibroblasts are attached to collagen matrix, the beta1 integrin/Src/PP2A-mediated 4EBP-1 regulatory pathway is activated, Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase)., The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells., Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators., These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration., SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations., Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner., In malignant melanoma, CD147/basigin regulates integrin beta1 signaling via the phosphorylation of focal adhesion kinase., There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration, Talin1 is required for inside-out activation of integrin beta1 during Bartonella henselae infection., Left ventricular assist device-induced reversed remodeling did not result in significant integrin protein expression, although changes in integrin mRNA expression suggested an adaptation to unloading., WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells., the integrin beta1 signaling pathway has an important role in regulating the nanofiber-induced fibroblast phenotypic alteration, examined integrin beta(1) , ECAD and rac1 expression in SCLC and analyzed the prognostic value of these markers, a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route, Results demonstrate differential effects of Snail and Slug in pancreatic cancer and identify the interplay between Rho signaling and beta1-integrin that regulates the scattering and migration of Snail- and Slug-expressing pancreatic cancer cells., Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., these data collectively indicate that beta1-integrin-related cell death is closely associated with EMT phenotypes and activation of the p53-p21 pathway is partly involved in the acquisition of resistance to apoptosis induced by beta1-integrin silencing., uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells, IGFBP2 activates integrin beta1 and downstream invasion pathways. The IGFBP2/integrin/ILK/NF-kappaB network functions as a physiologically active signaling pathway in vivo by driving glioma progression., Recombinant expression plasmid integrin-beta1- shRNA can inhibit the expression of integrin-beta1 gene and suppress the invasion of pancreatic carcinoma cells in vitro significantly., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression, The expression of beta1-integrin in glia is crucial for the proper development of the cerebellar cortex, whereas its expression in granule neurons is dispensable for cerebellar development., Dephosphorylation of FAK upon inhibition of beta integrin resulted in dissociation of a FAK/cortactin protein complex. This, in turn, downregulated JNK signaling and induced cell rounding, leading to radiosensitization., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer., analysis of the role of RICTOR in beta1 integrin-mediated cell survival and how receptor-specific mechanisms regulate phosphorylation of AKT at Ser473, Integrin beta1-mediated cellular adhesion to fibronectin confers drug resistance to mitomycin-C on bladder cancer cells. Knockdown of integrin beta1 may abolish the drug resistance phenotype and sensitize bladder cells to mitomycin-C., This study demonstrates that integrin beta1 mediates EGF-induced cell invasion in ovarian cancer., demonstrate with loss-of-function and rescue experiments that CD9 activates and MMP8 inactivates beta1 integrins and that both proteins associate with beta1 integrins in cells, The findings indicated that integrin a6b1 promotes the survival of brain endothelial cells by inhibiting prodeath signaling by TNF-R1, in part by inducing cellular FLICE inhibitory protein expression., Integrin b1/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial cells., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin beta1 sialylation, crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, The number of glycine residues in the PH domain is the key difference underlying the differential actions of cytohesin 2/ARNO and cytohesin 3/GRP1 in cell adhesion, spreading and beta1 integrin recycling., describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, The live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton., Integrin beta1 mediates vaccinia virus entry through activation of PI3K/Akt signaling., Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin., beta1 integrins should sense the stimulation of fluid shear stress and thus activate ERK1/2 through activating of FAK., The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome., decreased GnT-V activity due to inflammatory cytokine induction in human monocytes resulted in enchancement of integrin alpha5beta1-dependent monocyte-vascular endothelium adhesion and transmigration, There is no association between platelet collagen receptor polymorphisms GP VI T13254C or GP Ia C807T (alpha2beta1Integrin) and premature acute myocardial infarction in the Iranian population., These data suggest that Dab2-mediated recruitment of EH domain proteins selectively drives the internalization of the Dab2 cargo, integrin b1., Kindlin-2 and talin head do not interact with one another but can bind simultaneously to the integrin beta(3) tail without enhancing or inhibiting the interaction of the other binding partner., The regulation of alpha4beta1-dependent adhesion and migration of myeloma cells by CXCL12-S1P combined activities might have important consequences for myeloma disease progression., alpha5beta1 integrin transgene demonstrates an important angiogenic role by promoting brain endothelial cell proliferation in response to cerebral hypoxia., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit, Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., Combination of CD29 and CD44 can be used as markers to enrich cancer stem cells in human squamous cell carcinoma with epithelial-mesenchymal transition., These findings indicate that integrin beta1 has a major impact on HNSCC prognosis through its regulation of metastasis., CD151 links alpha(3)beta(1)/alpha(6)beta(1) integrins to Ras, Rac1, and Cdc42 by promoting the formation of multimolecular complexes in the membrane, which leads to the up-regulation of adhesion-dependent small GTPase activation, Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation., Tauroursodeoxycholic acid can directly activate intrahepatocytic beta integrins, which trigger signal transduction pathways toward choleresis., It was shown that mutations in the integrin beta1 tail NPXY motifs in the kidney produce phenotypes different from those seen in constitutive and skin-specific knock-ins., Provide further evidence that beta1 integrin can be a marker of poor prognosis in breast cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., Most actinic cheilitis cases showed reduced expression of integrin beta1 and superficially invasive squamous cell carcinoma lacked intergrin beta1 in the invasive front., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., In astrocytes transfected with a chimeric beta1 subunit, its activation is sufficient to cause centrosome assembly in the absence of cell adhesion., Data indicate that alpha3beta1 and the tetraspanin CD151 directly associate at the front and retracting rear of polarised migrating breast carcinoma cells., while alpha5beta1 integrin cross-linking contributes to the bacillus Calmette-Guerin response, it alone is insufficient to duplicate the full spectrum of bacillus Calmette-Guerin induced changes in urothelial carcinoma cell biology., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth., Examined the role of beta1 integrin in exocrine pancreatic structure and function. Compared with control pancreata, beta1 integrin-deficient pancreata showed reduced mRNA expression of extracellular matrix (collagen type Ialpha2, fibronectin and laminin) genes., Data show that TIMP-2-mediated inhibition of vascular endothelial cell permeability involves an integrin alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association., Gal-3 expression enhances beta1 integrin-mediated cell adhesion and cell migration., The chemokine domain of fractalkine binds to integrins alpha4beta1 and alphavbeta3., Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation., NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in renal cell carcinomas malignancy., Beta1 integrin is the main target for Cdc42-mediating interaction of cancer cells with endothelial cells and the underlying extracellular matrix, as exogenous beta1 integrin expression was sufficient to rescue the Cdc42-silencing phenotype., Expression of alpha and beta integrin subunits is increased on peripheral blood T cells in patients with asthma, study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation, Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced intracellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-dependent Akt activation, Mechanotransduction through beta(1)-integrins, FAK and p38 is required for anti-inflammatory effects of steady shear stress., data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone., Data indicate that Slug siRNA suppressed the TGF-beta1-induced integrin alpha3beta1-mediated cell migration ability of squamous cell carcinoma HSC-4 cells., Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation., The role of beta1 integrins and of a beta1 downstream target, c-Jun amino-terminal kinase 1 (JNK1), in regulating radiation-induced apoptosis in prostate cancer was studied., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation., osteopontin, LAMB3 and ITGB1 played important roles in the occurrence and metastasis of lung cancer, thus provided important clues to understanding the molecular mechanism of metastasis., beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma., Aberrant expression of E-cadherin and integrin beta-1 is closely related to malignant transformation and hydatidiform mole development., a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported., Data suggest that ITGB1 is critical ligand to enhance cell-extracellular matrix contact force and thus promotes cell proliferation; ITGB1 knockdown affects leiomyomal cell spreading but not adhesion; ITGB1 may function in progression of leiomyoma., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, Timp1 is assembled in a supramolecular complex containing CD63 and beta1-integrins along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway., Integrin beta1 interacts with SPARC in prostate cancer cells and suppresses cell proliferation and migration., provide the first evidence that beta(1) integrin-dependent migratory and metastatic competence of prostate cancer cells is enhanced by Trop-2, The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1., Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation., an important role of AnxA2 in controlling dynamics of beta1 integrin at the cell surface that in turn is required for the active turnover of cell-matrix associations, cell migration, and wound closure., Findings indicate that interactions between beta1-integrin and NF-kappaB p65 were induced in nonmalignant breast epithelial cells, but not in malignant cells, indicating context-specific regulation., Suggest that fibronectin fine tunes LM332-mediated migration by boosting bronchiolar cell adhesion to substrate via integrin alpha3beta1 integrin., High integrin beta 1 expression is associated with radioresistance in astrocytoma., Both CD9/CD81-silenced cells and CD151-silenced cells showed delayed alpha3beta1-dependent cell spreading on laminin-332., Integrin beta-1(+) and p75NTR(+) cells play an important role in wound healing process, MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, lipid raft integrity was required for beta1 integrin-mediated initial spreading of melanoma A375 cells on fibronectin., The data suggest that integrin beta1 is a potential biomarker for lymph node metastasis and prognosis of lung adenocarcinoma and integrin beta1 upregulation may play an important role in the pathogenesis of lung adenocarcinoma., These results showed evidence of Borrelia burgdorferi BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein., A specific association between alpha4beta1 and CD81, CD82 and CD151 was demonstrated and antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., changes in p38 mitogen-activated protein kinase expression together with recycling of adhesion receptors from the endosome leads to endothelial cell adhesion., These results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in beta1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells., 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., beta1-Integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer., These data uncover a potential role for PKP2 upstream of beta1 integrin and RhoA in integrating cell-cell and cell-substrate contact signaling in basal keratinocytes., integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion, NG2 knockdown results in loss of beta1 integrin activation in endothelial cells, revealing a mechanism for NG2-dependent cross talk between pericytes and endothelial cells., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, Expression of the VLA-4-stimulating factor sequence may help to predict melanoma prometastatic risk., Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., expression of beta1 integrin in OECM-1 cells is involved in the development of malignant phenotypes of OSCC, Data indicate that all mesenchymal colony clusters displayed a predominant CD44+/CD24- phenotype with decreased HER-2 expression and elevated levels of a beta1-integrin isoform with a high degree of N-glycosylation., CD44v6 and integrin-beta1 mRNA and protein expression in blood may serve as biomarkers for the development and metastasis of pancreatic cancer, Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells., Autophagy regulates cell migration, a central mechanism in cell development, angiogenesis, and tumor progression, by mitigating the cell surface expression of beta1 integrins., MARVELD1 plays a role in pre-mRNA processing of integrin beta1., the alpha1 integrin subunit in Bone marrow-derived mesenchymal stem cells is important for their ability to stimulate vessel morphogenesis., ss1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion., Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury., Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., The present study demonstrates miR-134-mediated negative regulation of beta1 integrin that influences cell adhesion to and of mesenchymal stem cells., Data indicate that levels of CXCR4 and VLA-4 did not predict acute lymphoblastic leukemia (ALL) prognosis in children, but Analysis of CXCR4 and VLA-4 levels at diagnosis in adults with ALL can provide useful information on patient prognosis., alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., Data show that nucleolin is a critical lipid-raft-dependent beta1-integrin-interacting protein in A375 melanoma cell spreading and migration on fibronectin., High VLA-4 expression is associated with brain metastasis., data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells., Data indicate that macrophage-derived exosomes regulate integrin beta1-dependent migration of endothelial cells., beta1 integrin signaling in human epithelial progenitor cell, SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin beta1 signaling pathway in hepatocellular carcinoma., beta-1,4-Galactosyltransferase III suppresses beta1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer., beta1 integrin expression represents a reliable prognostic factor regarding the grading of liver metastases of colorectal cancer, Integrin alpha3beta1 mediates regulation of COX2 mRNA stability in human breast cancer cells., ITGB1 enhances epithelial-mesenchymal transition via FAK-AKT signaling pathways., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, In high grade malignant tumors (G1), CDH1 and ITGB1 gene expression was the highest, in G2 and G3 tumors the expression of both genes was gradually lowering, mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the b1-integrin/ILK pathway., Data indicate that miR-134 suppressed the invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134., Low integrin beta 1 is associated with migration and invasion of colorectal cancer., Suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in airway epuithelial cells., Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive., Results indicate that the signaling critical to epithelial-to-mesenchymal transition (EMT) is regulated by the beta6 integrin cytoplasmic domain., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., beta1 integrin participates in calreticulin (CRT)-mediated cell adhesion in J82 human bladder cancer cells., These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways., VCAM-1/VLA-4-dependent activation of NF-kappaB has a role in mediating chemoresistance in leukemia cells, the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety, Data suggest that TIMP1 (tissue inhibitor of metalloproteinase-1) acts as chemoattractant for neural stem cells (NSC); TIMP1 enhances NSC adhesion, migration, and cytoskeletal reorganization; these effects are dependent on CD29/CD63 (granulophysin)., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation., the expression of integrin beta1 protein in cervical SCC tissues was significantly higher than that in the normal cervical tissues, and it increased with the clinical stage and the degree of malignancy., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, a Rap1A/beta1 integrin pathway, activated downstream of G-protein-coupled receptor stimulation and RhoA, in glioblastoma cell proliferation., phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that increases metastatic potential of prostate cancer cells., Results suggest that ITGB1 regulates the growth and apoptosis of human colorectal cancer cells., circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells., It plays a role in regulation of leukocyte migration to a site of inflammation., These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells., ITGB1 upregulation is involved in tumorigenesis and disease exacerbation by inflammatory cytokines as IL-6, TGF-beta1 and SDF-1, and targeting ITGB1 and the inflammatory modulator is a strategy for therapeutic intervention of ovarian carcinogenesis., abundance of LMTK3 positively correlated with that of the integrin beta1 subunit in breast cancer patient's tumors, Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543, When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., diabetic retinopathy is associated with ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension., C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity., Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 protein levels in prostate cancer cells, and increased lethality., lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier, Integrin beta1 and VEGF are overexpressed and microvascular density is increased in hypopharyngeal squamous cell carcinomas., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1., indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Data show that fluvastatin (FLV) attenuated the podocyte injury induced by puromycin aminonucleoside (PAN) and increased the production of beta1 integrin in podocytes., Data indicate that the interaction between S100A6 and integrin beta1, was confirmed by ELISA., Low NAMPT is associated with upregulation of beta1-integrin in breast tumor cells., The stimulatory cues of matrix rigidity were driven by b1 integrin mechano-sensing through FAK (pY397), and were associated with a posttranscriptionally driven rise in b1 integrin expression, This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway, CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility., our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling, The carbon monoxide signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand., Baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways., we demonstrate that beta1 integrins have a pivotal role in breast cancer bone colonization using unique tissue-engineered humanized bone models., The cytoplasmic tail of human integrin beta-1 contributes to fibroblast cell adhesion forces., role in stretch-induced renal fibrosis through the activation of c-Src and STAT3 signaling pathways, it is not just inactivation of Fyn that promotes multicellular spheroid formation but this must be coupled with the full length beta6 integrin., integrin alpha8beta1 has a protective role in arterial remodelling and atherosclerosis, These data provide evidence for CD147 as an important determinant of radioresistance via the regulation of integrin beta1 signaling., PCTK1-KAP0-myosin X-integrin beta 1 is a functional module providing a link between ECM and the actin cytoskeleton in the cell-extracellular matrix (ECM)-dependent control of spindle orientation., Data suggest expression of B4GALT3 in placenta is up-regulated in third trimester; overexpression of B4GALT3 suppresses trophoblast migration and enhances glycosylation of ITGB1; stability of ITGB1 may regulate trophoblast invasion in late pregnancy., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts., Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway., a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, an 'in solution' steady state organic fluorophore based quantitative fluorescence resonance energy transfer (FRET) assay to quantify VLA-4/VCAM-1 interaction., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway., DPP-4 and integrin beta1 interactions regulate key endothelial cell signal transduction in both physiological and pathological conditions including endothelial mesenchymal transformation., Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis., Hyperhomocysteinemia reduces BM CD34(+)/VEGFR2(+) generation and suppresses CD34(+)/VEGFR2(+) cell mobilization and homing to the injured vessel via beta1-integrin inhibition, which contributes to impaired re-endothelialization and vascular remodeling., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., ITGB1 SNPs might be a prognostic biomarker for CRC., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., the association between two genetic polymorphisms located in the VLA4 gene and the risk of multiple sclerosis, was investigated., HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion., CD105 and CD29 immunoexpression in decidua basalis, fetal membrane and placental villi showed significant negative correlations with the maternal age, This paper finds a regulatory role for beta1 integrins in the repair of radiogenic DNA damage via classical non-homologous end joining., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-related biological processes, Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship, We propose that PrP modulates beta1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin, and through the regulation of ERM-mediated membrane-cytoskeleton linkage., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma., based on the interaction motifs in Sdc1 and Sdc4, called synstatins (SSTN210-240 and SSTN87-131) competitively displace the receptor tyrosine kinase and alpha3beta1 integrin from the syndecan with an IC50 of 100-300 nm, Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility., HPW-RX40 restores the anoikis sensitivity in the metastatic breast cancer cells by inhibiting integrin beta1 and subsequent FAK activation., blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow, CXCL12/CXCR4 activation by cancer-associated fibroblasts mediated integrin beta1 clustering at the cell surface and promoted the invasive ability of gastric cancer cells, the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion., Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration., Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes., Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling., establish a paradigm according to which retrograde trafficking, and not endosomal recycling, is the key driver for beta1 integrin function in highly polarized cells, These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane., knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased, Inhibition of integrin beta1 activation on the cortex and disruption of its asymmetric distribution leads to spindle misorientation., G-CSF stimulates beta1 integrin expression and Swan 71 cell migration by activating PI3K and MAPK signaling pathways., GM2 mediats tumor cell migration by interacting with ITGB1 leading to downstream signaling and the phosphorylation of ERK MAP kinases.,
OFFICIAL_GENE_SYMBOL ITGB1,
SP_COMMENT function:Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis., online information:CD29 entry, PTM:The cysteine residues are involved in intrachain disulfide bonds., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subcellular location:Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells., subunit:Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with RAB21., tissue specificity:Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).,