Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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fibronectin 1(FN1) fibronectin 1(FN1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q34,
ENSEMBL_GENE_ID ENSG00000115414,
GENERIF_SUMMARY Binding of fibronectin by Trichomonas vaginalis is influenced by iron and calcium, We show a novel alternative pathway of apoptosis that is regulated by the alternatively spliced V region and high-affinity heparin-binding domain of fibronectin, Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride, Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading., Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus; multivariate analysis showed that plasma fibronectin levels were not an independent predictor of LV thrombus formation., Low density lipoprotein receptor-related protein (LRP) functions as a catabolic receptor for Fn, Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11)., differential role of u-PA and t-PA as inducers of fibronectin mRNA, investigation of the role of direct contact with stroma and the ECM protein fibronectin in the preservation of normal but not chronic myelogenous leukemia primitive hematopoietic progenitors, Adhesion of hairy cells to fibronectin inhibits interferon-alpha-induced apoptosis., fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility, Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2., proximal tubular cell fibronectin production induced by oleate-complexed recombinant human serum albumin was mediated via protein kinase C activation, These data indicate that fibronectin polymerization is a critical regulator of extracellular matrix organization and stability., familial combined hyperlipidemia plasma stimulated secretion of several distinct hepatic proteins, among which fibronectin was identified, FN may be partly involved in the increase in SPARC (secreted protein, acidic and rich in cysteine) glycoprotein expression by TGF-beta 1 in human periodontal ligament (HPL) cells., REVIEW, Streptococcus pyogenes isolates were able to recruit collagen type IV via surface-bound fibronectin; fibronectin-mediated collagen recruitment represents a novel aggregation, colonization and immune evasion mechanism of S. pyogenes, FN may have a role in the pathogenesis of papillary thyroid carcinoma, all six modules of the gelatin-binding domain contribute to the interaction with gelatin either directly by contacting the ligand or indirectly through module-module interactions, differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the Sturge-Weber syndrome (sws) normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS., Fibronectin secretion by renal fibroblasts was increased upon exposure to high glucose, but with delayed kinetics compared to TGF-beta1-induced fibronectin., Pathogenic bacteria, Staphylococcus aureus and Streptococcus pyogenes, attach to human fibronectin through a tandem beta-zipper, AngRem104 is a novel human gene potentially involved in regulation of fibronectin induced by AngII in human mesangial cells., An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases., an additional marker of malignant potential of thyroid nodular lesions (oncofetal fibronectin), levels of fibronectin in the extracellular matrix are regulated by uPAR and integrin receptors, FN and IGFBP-5 bind to each other, and this binding negatively regulates the ligand-dependent action of IGFBP-5 by triggering IGFBP-5 proteolysis., Fibronectin plus TNF-alpha stabilizes granulocyte macrophage-colony-stimulating factor (GM-CSF) mRNA, increases GM-CSF secretion, and prolongs in vitro eosinophil survival., Abundant expression of fibronectin is a major feature of leukemic dendritic cells differentiated from patients with acute myeloid leukemia, the aggrecanase activity of ADAMTS4 is inhibited by fibronectin through interaction with their C-terminal domains, crystal structure of the 2F1(3)F1 module pair, human fibronectin binding to streptococcus requires specific recognition of sequential F1 modules, Adding 110-120 kDa fibronectin fragments to normal blood replicated changes in monocyte CD49e, CD62L, CD11b, & CD86 seen in vivo in HIV-1 patients. FNf caused monocytes to release proteinase-3. Monocyte behavior in HIV-1 patients may be affected by FNf., Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., fibronectin concentration significantly elevated in ovarian cancer patients with recurrent disease compared with ovarian cancer patients without recurrence, demonstrate that integrins alpha(5)beta(1) and alpha(v)beta(3) support fibronectin-dependent platelet adhesion and the generation of filopodia but that, in contrast to the integrin alpha(IIb)beta(3), are unable to promote formation of lamellipodia, Site-directed mutagenesis of amino acids coordinating Ca2+ drastically decreased the binding of C-reactive protein to fibronectin (Fn), indicating that the Ca2+ -binding site indeed formed the Fn-binding site., Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, integrin-dependent function of the ninth and tenth FIII domains of human fibronectin depends on interdomain tilt angle, adhesion of uveal melanoma cells to the extracellular matrix proteins fibronectin, type IV collagen and laminin might confer resistance to the chemotherapeutic agent cisplatin, The heparin II domain of fibronectin mediated the incorporation of paxillin into focal adhesions., Fibronectin enhances IL-1 beta-dependent airway smooth muscle cell secretory responses through a beta 1 integrin-dependent mechanism., SGK1 activation has a role in oncofetal fibronectin expression, Fibronectin and ezrin were upregulated in primary laryngeal carcinoma., Fibronectin 1 and RAB10 show elevated expression in uninvolved psoriatic epidermis., FN modulates thyroid cancer cell adhesiveness and, at least in part, mediates vitamin D actions on neoplastic cell growth., The relative amounts of the 60, 90 and 100 kDa FN fragments were 2-3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group, suggesting that seminal plasma FN fragments may contribute to fertilization., FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, Chemical shift differences between the fibronectin glycoforms have revealed an intimate interaction between one N-linked sugar and the polypeptide that is critical for gelatin binding., Over-expression of oncofetal fibronectin is associated with thyroid carcinoma, binding with C terminus of apolipoprotein [a], These results provide evidence for an additional level of control of fibronectin deposition through cell interactions with the local microenvironment., the role of the extra domain A (EDA) and type III connecting segment (IIICS) of fibronectin in fiber assembly, topographical distribution and proteolytic cleavage, Results show fibronectin plays a role in the regulation of hematopoiesis by binding to FLRG and follistatin., platelet fibronectin may have a role in progression of coronary artery disease, The expression of FN protein was higher in cortex cataract than in nuclear cataract., Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, Results indicate that the adhesion mechanism by embryonal fibronectin may be involved in human blastocyst implantation., constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP, review goes over roles of fibronectin in platelet functions with a focus on fibronectin assembly within developing platelet thrombi., Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., IL-1, FN, and FN-derivatives have interrelated roles in determining biomaterial-modulated macrophage function [review], The role of the matricryptic site of the fibronectin terminal repeat III1 in cell proliferation and growth is reported., Review highlights the role of fibronectin as a key orchestrator for the assembly of multiple extracellular matrix proteins., Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP., the FN1 alpha-helix is involved in an Ig5-FN1 interaction that is critical for the correct positioning of Ig5 N-glycans for polysialylation, analysis of L-isoaspartate formation and gain of function in fibronectin, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., Downregulated expression of migration-inducing FN-isoforms in contrast to unchanged FN receptor expression may contribute to the observed alterations of Crohn's disease colonic lamina propria fibroblasts migration., Our results indicate that Src maintains fibronectin matrix at the cell surface through its effect on integrin activity and paxillin phosphorylation., fibronectin does not have an obvious role in development or progression of coronary artery disease, epithelial fibronectin suppression is not only involved with malignancy, but can also occur with benign processes that involve leukocyte migration, local presence of endogenous Tlr4 ligand Fibronectin EDA is not associated with in an unstable plaque phenotype in humans, Interaction of fibronectin carboxy-terminal regions with the fibrin alpha C chain occurs through two types of binding sites, one with high affinity and another one with much lower affinity, both of which play a role during hemostasis and wound healing., Smad 7 transfection reduces the expression of COL1A2 mRNA and the synthesis of type I collagen, but has no effect on fibronectin mRNA expression., ED-B fibronectin expression is closely associated with inflammation in atherosclerosis., The IIICS region of FN is a novel zinc-binding module., Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production, MspI and HaeIIIb FN gene polymorphisms may be clinically relevant to define the risk of lymphoma development in MCsn., TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., Fibrinogen has a role in controlling human platelet fibronectin internalization and cell-surface retention, study concludes that increased platelet fibronectin may partially contribute to platelet aggregation in patients with coronary artery disease, Expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC., These findings provide evidence that mutations in fibronectin, induce anoikis in human squamous cell carcinoma cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK., high molecular weight hyaluronan suppresses HBFN-f-activated NF-kappaB in rheumatoid arthritis chondrocytes, Results show that neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2)is co-expressed with migration stimulating factor (MSF or FN1) by keratinocytes and acts as a functional inhibitor of MSF., expression of the alternatively spliced extra-domain A (EDA) of fibronectin in the neovasculature of metastases and primary tumors of human cancer patients was shown, TSG-6 is a high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells, These data provide the first evidence that IL-18 and FN stimulate each other's expression., These results suggest that fibrinogen and fibronectin facilitate the adherence of Paracoccidioides brasiliensis conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system., dominant mutations in FN1 accounted for 40% of cases of Glomerulopathy with fibronectin (FN) deposits in our study group, These results are consistent with the hypothesis that ScpB binds to a motif created by the juxtaposition of multiple Fn molecules., The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin., Filtering bleb scarring is associated with an abundant expression of TGF-beta receptors in activated fibroblasts and the deposition of the fibrogenic ED-A fibronectin splice-variant., MMP-2 enhanced peritoneal adhesion of ovarian cancer cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments, KLK7 is able to cleave fibronectin in a time-dependent manner, but not laminin., Increased production of a fibronectin isoform containing the oncofetal domain and its release in the circulation in patients with primary biliary cirrhosis is at least partially responsible for the decrease in bone formation., Results advance a new model wherein Fn polymerization serves as a structural scaffolding that displays adhesive ligands on a mechanically ideal substratum for promoting neovessel development., A link between fibronectin expression and epithelial cell growth during development and oncogenesis in the mammary gland., Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., Inflammation-induced modulation of FN-isoform production is involved in the alterations of migratory potential of CLPF isolated from CD mucosa., elevated plasma fibronectin levels are associated with venous thromboembolism (VTE) especially in males, and extend the potential association between biomarkers and risk factors for arterial atherothrombosis and VTE, four crystal structures that together comprise the structures of two complete high-affinity binding repeats for Fn from FnBPA and FnBPB, each in complex with four of the N-terminal modules of Fn, Plasma fibronectin level is increased in patients with severe coronary artery disease, namely, those who have at least one critically stenosed coronary vessel, compared to patients with normal coronary arteries., analysis of fibronectin expression in benign hyperplasia and cancer of the prostate, These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Genotyping for HaeIIIb fibronectin gene polymorphisms may be clinically relevant to define the predisposition to the major clinical manifestations in mixed cryoglobulinemic syndrome., a new mechanism of fibroblast activation, which is initiated by interaction of fibronectin with its integrin receptors., MAGE A3 is a functional integrator of diverse signals, including FGFR2 and FN, to modulate cancer progression., Caveolin-1 plays a dual role in the fibronectin assembly regulated by uPAR signaling., The simultaneous positivity for thyroid specific factor TTF-1 and onfFN suggest they might represent putative thyroid cancer stem-like cells., analysis of the unfolding of the tenth type-III repeat of human fibronectin, Dynamic mechanical forces could regulate the expression of collagen type I and fibronectin mRNA in periodontal ligament fibroblasts., Mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and FNI(9)., enhanced capacity of fibronectin-adherent HL60 cells to differentiate into macrophages in response to PMA., The 320-kDa and 280-kDa FN forms as well as FN fragments appeared in the pleural effusion and plasma of patients suffering from lung inflammation or cancer in significantly higher relative amounts in both lung cancer groups than in the inflammation., relative amount of EDA-FN in synovial fluid, but not in plasma samples, was significantly lower in the early RA group than in established and late RA. In contrast, its level did not correlate with the CRP concentration, The risk of pneumoconiosis increases in workers with the FN (MspICC or HaeIIIb AA) genotype after exposure to dust. Workers both carrying FN (HaeIIIb AA) and (MspICC) genotypes are more susceptible to pneumoconiosis., role for fibronectin in collagen proteolysis and tissue remodeling, Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30., These results established a novel in vitro dynamic BBB model. We also demonstrated the dependence of leukocyte-endothelial interactions in this model on alpha4 integrins and FN-CS1., Human umbilical vein endothelial cells showed dose-dependent upregulation of fibronectin mRNA exposed to various D-glucose levels., Borrelia burgdorferi virulence factor BBK32 induces the formation of Fn aggregates that are indistinguishable from those formed by anastellin., isoforms of a group B streptococcus-secreted component named Fib displayed differential binding capacities for fibronectin, fibrinogen, and C4BP, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., fibronectin might be a critical molecule produced by T(H)1 cells involved in pathogen eradication., the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., LigB was shown to bind to the N-terminal domain of fibronectin., HindIII polymorphism of the FN1 gene is highly associated with calcium oxalate stone disease, FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases., Serum fibronectin concentration in patients with hemorrhagic fever with renal syndrome (HFRS) was increased with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity., higher expression in the fetal skin than in adult skin, AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., Exposure to high glucose and overexpression AR increase the expression of fibronectin., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., the third FN type III repeat (FnIII3) and several fragments containing the repeat promote cell spreading and migration of human dermal fibroblasts (HDFs), whereas the fourth repeat (FnIII4) did not., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., Data show that the expression of collagen types I, III and fibronectin was significantly higher in pancreatic cancer, and the expression of collagen type IV, laminin and vitronectin was significantly lower in pancreatic cancer., vaginal fetal fibronectin not changed by vaginal ultrasound, Upregulation of fibronectin-1 protects Dicer knockdown HEK293T cells against apoptosis., findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., Increase in urinary fibronectin is associated with bladder tumor., The identification of a fibronectin-binding domain in ameloblastin might permit interesting applications for dental implantology., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., iso-DGR sequences spontaneously converted from NGR are cryptic and do not mediate the interaction of the 70K region of FN with the cell surface during FN assembly, Mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human cancer cells., Data demonstrated that the inclusion of the alternatively spliced angiogenesis-associated ED-B leads to the unmasking of the FNIII 8 B-C loop that is cryptic in FN molecules lacking ED-B., Exposure to ethanol drastically enhances the adhesion of cultured breast cancer cells to fibronectin and increases the expression of focal adhesions., Fibronectin promotes paxillin (tyr118) phosphorylation and invasiveness of AGS cells., An increased expression of fibronectin and tenascin-C mRNA in association to histological damage and in valvular heart disease compared to coronary artery disease could be shown., Fibronectin may modulate the directional migration of corneal epithelial cells, The expression of Col I, Col IV and Fn was closely related to tumor invasion, the regional lymph node metastasis and other pathological features in laryngeal squamous cell carcinoma., our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells., Steric hindrance determines the motogenic activity of MSF and Fn, and that both molecules contain cryptic bioactive fragments., in the presence of laminin and fibronectin, DC maintain a 'more immature' phenotype and express higher levels of key endocytic receptors, and become better endocytic cells, but possess superior ability to induce antigen-specific T cell differentiation., Oncofetal fibronectin transcripts are highly abundant in the peripheral blood of patients with papillary thyroid carcinoma., Elevated urinary fibronectin was identified as an independent factor predicting kidney function deterioration., Data show that metastatic outgrowth is associated with activation of the transforming growth factor-beta signaling pathway and concerted up-regulation of POSTN, FN1, COL-I, and VCAN genes., plays role in bronchial smooth muscle cells migration in the process of airway remodeling, Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac activation by mGBP-2., Data show that occupancy of EPCR by protein C switches signaling specificity so that activation of PAR-1 by thrombin inhibits TNF-alpha-mediated synthesis of IL-6 and IL-8 and down-regulates TGF-beta-mediated expression of collagen type 4 and fibronectin., MSF is a novel marker associated with the M2 stage of macrophage polarization expressed by tumor-conditioned macrophages; MSF may contribute to macrophage-mediated promotion of cancer cell invasion and metastasis., high molecular weight of HA suppressed the FN-f-activated p38 via ICAM-1 and the CD44 in RA chondrocytes, Migration Stimulating Factor, a truncated form of fibronectin that promotes the migration of many cell types, inhibits AKT activity in human fibroblasts, data indicate that higher levels of EDB isoform and FN-f are associated with intervertebral disc degeneration; this shift in alternative splicing may reflect an attempt of tissue repair and remodeling, FN induces MMP-9 in HEp-2 cells mainly by involving integrin receptor alpha5beta1 and involves activation of multiple signaling pathways which independently or in "cross-talk" to each other finally leads to the transactivation of the MMP-9 gene., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, Fetal fibronectin as a predictor of spontaneous preterm birth., Data show that FN III12-14 is a highly promiscuous ligand for GFs and also holds great potential in clinical healing applications., FN upregulates osteoclast activity despite inhibiting osteoclast formation and that these effects involve NO and IL-1beta signaling., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., Tenascin-C contains cryptic sites which can control tissue levels of fibrillar fibronectin either by preventing de novo fibril assembly or reducing levels of deposited fibronectin., In the plasma group, the mean N-terminal FN domain immunoreactivity was about one fourth that of the cell-binding and C-terminal domains, whereas in cerebrospinal fluid they were nearly equal., The findings that fibroblast survival is dependent on FN-growth factor binding domains underscore the critical importance of pericellular matrix for cell survival, CTGF cooperates with FN in enhancing the attachment and migration of corneal epithelial cells., Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion., IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin, High FN1 mRNA expression is associated with renal cell cancer., rhFNHN29 and rhFNHC36 inhibit adhesion and invasion of liver cancer cells, syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides, study suggests that FN and tissue transglutaminase (TG2) facilitate the metastatic activity of A431 tumor cells, and this may be partly attributed to TG2 enhancement of the association of FN and beta integrin, These results highlight a crucial role for caveolin-1 in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins., Megakaryocyte adhesion to type I collagen promotes inhibits pro-platelet formation through the release of cFN to the plasma membrane. This regulatory mechanism is dependent on the engagement of FN receptors and on transglutaminase FXIII-A activity., autocrine soluble fibronectin of osteosarcoma MG-63 cells may be involved in cell shape maintaining, Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve., FN upregulation of cGMP-dependent protein kinase (PKG-I) protein content is due to increased mRNA expression via augmented transcriptional activity of the PKG-I promoter region., Cav1.2 calcium channel association with alpha5beta1-integrin depends on adhesion to fibronectin; interactions between alpha5beta1-integrin and fibronectin modulate L-type calcium channel entry., Fetal fibronectin may be used as a primary screening tool for prediction of preterm birth in asymptomatic high-risk women., Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP., Danshensu can protect from oxidative stress through inhibiting the expression of FN and Col-I induced by high glucose., Kindlin-2 regulates podocyte adhesion and fibronectin deposition through interactions with phosphoinositides and integrin b1 and b3., Data show that ITP-79 modulated binding of TG2 to fibronectin., LigB could facilitate leptospirosis transmission by binding fibronectin and fibrinogen, Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression., Increase expression of sialic fibronectin correlates with lymph node metastasis of thyroid malignant neoplasmas., This work provides a broad overview of matrix remodeling at the cell-material interface, establishing correlations between surface chemistry, fibronectin adsorption, cell adhesion and signaling, matrix reorganization and degradation., We conclude that TGF-beta1 may both switch on and switch off migration stimulating factor (MSF) expression in a manner critically determined by the nature of the matrix substratum, Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage, Data show that the urinary messenger RNA (mRNA) levels of alpha-smooth muscle actin (alpha-SMA), fibronectin, and matrix metalloproteinase-9 (MMP-9) were significantly higher in the diabetic nephropathy (DN) group, and mRNA levels increased with DN progression., Structural and functional analysis of the tandem beta-zipper interaction of a Streptococcal protein with human fibronectin, Results show that higher body temperature within the first 24 h from stroke onset is associated with HT in acute ischaemic stroke untreated with rtPA, independently of biomarkers of BBB disruption, such as MMP-9 and cFn., The adhesive properties and thickness of the UspA1 layer at the cell surface varies on addition of either fibronectin or CEACAM1., miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line., the extent of molecular unfolding that contributes to Fn fiber extension, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted AGS cell migration was due to the up-regulation of fibronectin., Fibronectin matrix assembly suppresses dispersal of glioblastoma cells, Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier, Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein, first step in such infections is a bond that forms between fibronectin-binding protein (FnBP) on Staphylococcus aureus and host proteins, such as fibronectin (Fn), that coat the surface of implants in vivo., Data indicate that anti-citrullinated fibronectin peptide antibodies are associated with HLA-DRB1 shared epitope alleles., Allosteric loss of constraining interactions among (1-5)FNI, (10)FNIII, and (12-14)FNIII likely enables assembly of FN into extracellular fibrils., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, these findings provide evidence that extra domain A of fibronectin could play a role in tumor-induced lymphangiogenesis via upregulating autocrine secretion of VEGF-C in colorectal cancer, which is associated with the PI3K/Akt-dependent pathway., Study demonstrated that fibronectin inhibition and neutralization by specific antibody prevented significantly the adhesion of A. baumannii to human lung epithelial cells (A549 cells)., study concludes that increased serotonylation of fibronectin occurs in pulmonary hypertension, Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin, High expression of fibronectin is associated with esophageal squamous cell carcinoma., Data suggest that fibronectin 1 (FN1) is a promising biomarker candidate for clear cell renal cell carcinoma (RCC)., Genistein attenuates advanced glycation end product-induced expression of fibronectin and connective tissue growth factor, Collagens regulate the EDA(+)-FN-ECM organisation at transcriptional and post-transcriptional level and activate the alpha5beta1-FAK complexes., Gene expression profiles showed that FN1 was up-regulated in epidermolysis bullosa subtypes., Reduced expression of two specific integrin subunits, alpha 5 andalpha V, resulted in the inability of MG63 cells to deposit fibronectin into their extracellular matrix, influenza A Virus entry with a alpha2,6-linked sialic acid binding preference requires host fibronectin, MMP-2 cleaves fibronectin into small fragments to enhance the adhesion and migration of human melanoma cells mediated by alphavbeta3 integrin., FN1 assembly and the lung colonization of suspended CL1-5 cells were inhibited when endogenous A1AT protein was knocked down using siRNA., MSF functions in the metabolic remodeling of the tumor microenvironment., Studies indicate that progenitor endothelial cells (ECs), endothelial colony-forming cells (ECFCs), deposit collagen IV, fibronectin, and laminin., our results suggest that plasma PTPalpha and fibronectin may be associated with opisthorchiasis., Data indicate that fibronectin mRNA and protein levels were significantly down-regulated following the upregulation of serine protease HTRA1., Serum oncofetal fibronectin mRNA in differentiated thyroid carcinoma cannot identify those with metastatic disease., FN1 and ITGA4 are potential oral squamous cell carcinoma biomarkers for tongue/mouth floor and edentulous ridge., Data indicate that rheumatoid synovial fibroblasts have impaired adhesion and spreading on citrullinated fibronectin, but focal matrix degradation is unaffected by citrullinated fibronectin., We confirm WNT4, CDKN2BAS and FN1 as the first identified common loci for endometriosis., An algorithm based on fetal FN for management of preterm labor (PTL) does not reduce evaluation times for triage, hospital admissions or preterm deliveries., Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression in the U87 glioblastoma cell line, Authors hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of Toxoplasma gondii replication during toxoplasmic encephalitis., Lactobacillus iners AB-1 displays a mechanism of vaginal persistence to human fibronectin, with implications for human reproductive health., Authors report that group A Streptococcus biofilm formation is mediated by the Scl1 interaction with extra domain A-containing cellular form of fibronectin., Data indicate that citrullinated fibronectin (cFn) plays a potential pathophysiologic role in rheumatoid arthritis (RA) by inhibiting apoptosis and increasing proinflammatory cytokine secretion of fibroblast-like synoviocytes (FLSs)., Data indicate that four different Anticalins all show low nanomolar affinities for fibronectin (Fn) extra-domain B (ED-B)., MOMCs were obtained on the fibronectin., Differences in stromal cell ability to induce angiogenesis are a result of differences in the secretion of fibronectin., genome-wide association study of population in Northern Belgium, Data indicate that endopeptidase O (PepO) is a ubiquitously expressed plasminogen- and fibronectin-binding protein, which plays role in pneumococcal invasion of host cells and aids in immune evasion., The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8., Treated neutrophils aggregate on fibronectin (Fn)-coated wells and exhibit an exaggerated cell aggregation phenotype on wells coated with Fn plus beta-glucan., The metabolism of glucose through hexosamine biosynthetic pathway promotes O-glycosylation of the oncofetal form of FN during epithelial-mesenchymal transition modulating tumorogenesis., fibronectin is a key factor in human serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture., Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis., High glucose and AGEs can up-regulate the expressions of ROS and fibronectin in human mesangial cells by activating transcriptional co-activator p300., Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN)., Collagen association stabilizes a distinct monomeric fibronectin gelatin-binding domain conformation in solution., Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer., The predicted 23-residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with the tenth FN type III domain., We identified 31 interactors from plasma, of which only seven were previously known to interact with fibronectin, Data indicate tht mRNA expression of elastin, procollagen I type I, fibronectin, Col1alpha1, and TIMP-1 had a significant increase after bicyclic[1,2,3]triazoles plus UVA treatment, while the MMP-1 decreased, compared with the UVA irradiated group., We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, MSF expression was upregulated in NSCLC tumors and promoted migration and invasion in A549 cells., study highlights that ascites-derived fibronectin and vitronectin exhibit different properties depending on the ascites, Four members from clusters of the miR-200 family (miR-200a/-200b/-429 and miR-200c/-141), epithelial-mesenchymal transition could potentially play a role in the pathogenesis of pterygium., Low extra domain A fibronectin expression is associated with bacterial meningitis., The SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells, The presence of VN on the material surfaces enhanced cell-mediated FN reorganization and secretion., Data suggest that determination of the fibronectin content can serve as a prognostic biomarker for breast and prostate cancers and possibly other cancers., Together these results show that FN produced by the tumor cells has a role in glioblastoma multiforme pathophysiology and they provide insights into the implications that targeting FN interactions may have for combating this dreaded disease., profile of fibronectin fragmentation and alterations of fibronectin domain immunoreactivities in seminal plasma may influence their engagement in the fertilisation process, First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for gestational diabetes., We demonstrate that the high FN content of the endometrium matrix, and not specifically the EDA domain, supports trophoblast invasion by showing that forced incorporation of plasma FN (EDA-) promotes efficient trophoblast invasion, Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy., Perturbing the mesenchymal regulators, platelet-derived growth factor (PDGF) receptors or fibronectin, reverts mesenchymal stromal/stem cells (MSCs) toward mesodermal progenitors with endothelial potential., cFN isoform expression in the TM ECM may be a novel pathologic mechanism involved in the TM changes associated with glaucoma., expression of miR-206 and its target gene, fn 1, may contribute to the progression of bronchopulmonary dysplasia, Fibrillins require the complete gelatin-binding region of fibronectin for interactions., Fibronectin is upregulated in a subset of nasopharyngeal carcinomas , and its increased immunoexpression significantly correlated with advanced features, justifying the potentiality of fibronectin as a theragnostic biomaker of nasopharyngeal carcinomas ., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., the dual antibody approach utilizes commercially available antibodies and simple immunohistochemistry, thus making it accessible to a wide range of scientists interested in fibronectin mechanobiology, Oncofetal fibronectin levels are potentially useful as a biomarker for urothelial inflammation and repair., Eppin and Fn bind to each other in human semen and on human ejaculated spermatozoa., Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens., Identify FN1(high)MITF(low) cell type in melanoma associated with ischemic necrosis, and propose these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment., This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in Duchenne muscular dystrophy patients., Serum C4b, FN, and PEPD are associated with the pathological changes of pulmonary tuberculosis., Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5., Data indicate that ibrinogen binding to Staphylococcus aureus fibronectin-binding protein A (FnBPA) is sterically regulated by fibronectin binding., Most of these motifs are located on the F1 and F3 faces of the Hap passenger domain structure, suggesting that the F1 and F3 faces may be responsible for the Hap passenger domain-fibronectin interaction., Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition, We proved that the CD157-fibronectin interaction occurs with living cells, where it elicits CD157-mediated cell responses., MMF could inhibit MCP-1 expression and the secretion of FN, indicating that it may delay the progression of glomerulosclerosis and interstitial fibrosis in diabetic nephropathy to ultimately achieve protective effects on the kidney., Data indicate the expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in cardiac tissue from heart transplant recipients., The mean level of cellular fibronectin expression in cases with liver fibrosis was significantly higher than the corresponding level in cases with liver cirrhosis., rFN/CDHs may induce hMSCs differentiation into osteoblasts and PLGA/collagen nanofibers loaded with rFN/CDHs have potential in bone tissue engineering., The AT heterozygote in FN-1 (rs940739A/T) was found to be significantly associated with knee osteoarthritis in 2 case-control studies. FN-1 rs6725958C/A was significant only if both studies were combined., Results found that the majority of colorectal cancer cases with depressed tumors had a higher frequency of elevated FN1 expression., High fibronectin expression is associated with thyroid papillary carcinoma follicular variant., the possible regulatory effect of fibronectin peptides in liver fibrosis was further supported by the ability of these peptides to induce metalloprotease-9 (MMP-9) expression in human monocytes., homophilic fibronectin binding peptides might have novel applications in the field of tissue regeneration as tools to regulate neovascularization via VEGF signaling, serum levels of both fibronectin and vitronectin may be the diagnostic markers in melanoma patients, but not markers of prognosis, Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells., Study tested the role of the histone acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon; these data suggest that histone acetylation could be one of the mechanisms how promoter and promoter binding proteins influence alternative splicing., Data indicate that the IL-33/ST2 protein pathway may promote airway remodeling in asthma through activating HLF-1 fibroblast to over-express fibronectin 1 (FN1) and type 1 collagen (Col1)., fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis, These results have indicated that the cysteine proteinase of Trypanosoma cruzi metacyclic forms, through its fibronectin-degrading activity, is implicated in host cell invasion., PEDF inhibited breast cancer cell migration and invasion by down-regulating fibronectin, Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour., Data indicate that the interaction between the alpha4beta1 integrin and the EDA domain of fibronectin helps to drive tissue fibrosis by promoting a contractile phenotype and an increase in fibronectin synthesis and deposition., The expression of terminal sugars on milk FN is different from that of plasma FN of the lactating mother and is associated with milk maturation., Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells., Fibronectin gene expression has a potential role in the pathogenesis of keloid., Genetic induction of fibronectin by HER2 triggers cell adhesion and invasion capacities., Our results indicate that invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which process includes decrease and partial replacement of fibronectin and collagens by a laminin-rich matrix, we describe a new type of hybrid molecules including 10th type III human fibronectin domain (10Fn3) - one of the alternative scaffold proteins which can be used for the construction of antibody mimics with various binding specificity, Serum fibronectin was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. Fibronectin increased with nephropathy severity., Fn Msp iv polymorphism appeared to be associated with diabetic nephropathy susceptibility., Serum- and CSF-FN levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis., These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway., Data show that the amount of the the extra domain-B (EDB) splice variant of fibronectin (FN) produced by endothelial cells increases with matrix stiffness., The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, An observed increase in PLD activity was mediated through boosting the binding of PLD with dynamin which in turn facilitated fibronectin-induced cell spreading., Asthmatic human bronchial epithelial cells are intrinsically primed to produce more fibronectin, which when deposited into the extracellular matrix, is capable of driving remodeling and inflammation., The pathogenic H5N1 and H7N9 influenza virus variants cause more severe deregulation of NRF2 and fibronectin in host epithelial cells than the less pathogenic H1N1 variant., Study determined the structure of third type III domain, 3FN3 using nuclear magnetic resonance spectroscopy, and investigated its stability, folding, and unfolding., polymorphisms in rs6725958, rs10202709, and rs35343655 of the Fn gene had no obvious effect on the susceptibility to the development of calcium oxalate stones in the Uighur population, residing in the Xinjiang region of China., Fibronectin binding to heparan sulfate mediates exosome-cell interactions in Myeloma., the correlation between placental DNAm of INHBA/FN1 and maternal serum INHA/FN1 levels indicate that DNAm may be a useful tool to identify novel biomarkers for adverse pregnancy outcomes in some cases., that strong FN1 promoter activity drives inappropriate expression of the biologically active portion of EGF, These results suggest novel functions of endogenous FN involved in immune evasion and maintenance of hepatitis b virus replication.,
OFFICIAL_GENE_SYMBOL FN1,
OMIM_DISEASE Glomerulopathy with fibronectin deposits 2, Plasma fibronectin deficiency,
SP_COMMENT alternative products:Additional isoforms seem to exist, developmental stage:Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age., disease:Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life., function:Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth., online information:Fibronectin entry, PTM:Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)., PTM:It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated., PTM:Sulfated., similarity:Contains 12 fibronectin type-I domains., similarity:Contains 16 fibronectin type-III domains., similarity:Contains 2 fibronectin type-II domains., subunit:Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7., tissue specificity:Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.,
heparan sulfate proteoglycan 2(HSPG2) heparan sulfate proteoglycan 2(HSPG2) Related Genes Homo sapiens
CHROMOSOME 1,
CYTOBAND 1p36.1-p34,
ENSEMBL_GENE_ID ENSG00000142798,
GENERIF_SUMMARY Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia, Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy., Identification of integrin alpha(M)beta(2) as an adhesion receptor on human peripheral blood monocytes for Cyr61 and connective tissue growth factor, CTGF/Hcs24 produced in the hypertrophic region may act on chondrocytes in the proliferative and maturative zone via some heparan sulfate proteoglycan, such as perlecan., progranulin/perlecan interactions have a role in the fine regulation of tumor angiogenesis, expression of perlecan, but not other HSPGs, is dramatically down-regulated in human umbilical vein endothelial cells (HUVECs) treated with antiangiogenic cleaved and latent forms of antithrombin but not with the native form., HSPG2 A allele may possess an additive risk effect in APOE epsilon 4 carriers in a Finnish population with Alzheimer's disease., results demonstrate that extracellular matrix perlecan is a degradative target of heparanase (HPSE-1), increased expression associated with Cyclosporin A-induced gingival overgrowth, Hyperglycemia-induced structural changes in perlecan may result in a subendothelial matrix that is more favorable to retention of monocytes., findings show no evidence for association between HSPG2 intron 6 BamHI polymorphism and Alzheimer's disease in a Jewish population, and no interactive effect was found with the known risk factor apolipoprotein E (APOE) epsilon4., Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin, We conclude that the perlecan mediates Tat uptake and is required for HIV-1 LTR-directed transactivation in WiDr cells., High affinity interactions between fibrillin-1 and perlecan were found by kinetic binding studies with dissociation constants in the low nanomolar range., The gene expression of perlecan is partially suppressed by antiangiogenic forms of antithrombin., Results describe perlecan purified from HEK-293 cells substituted with heparan sulphate, chondroitin sulphate and keratan sulphate; first to report perlecan containing keratan sulphate, perlecan regulates both the survival and terminal differentiation steps of keratinocytes, Perlecan is an essential extracellular matrix component involved in growth responses of metastatic prostate cancer cells to heparin-binding growth factors deposited in local and metastatic microenvironment, WARP forms macromolecular structures that interact with perlecan to contribute to the assembly and/or maintenance of "permanent" cartilage structures during development and in mature cartilages, The expression level of perlecan and perlecan mRNA significantly increased in Hep-2 cells as compared with normal cells., Reduction of perlecan mRNA-expression and protein deposition in human atherosclerosis, which in part explains the low levels of heparan sulfate in this disease., perlecan secreted by VEGF165-stimulated endothelial cells may be involved in the regulation of cellular behavior during angiogenesis, perlecan is a prominent pericellular proteoglycan differently expressed in fetal, postnatal, and mature hyaline cartilage, The HSPG2 BamH I polymorphism C/A of intron 6 may not represent an additional genetic risk factor for late-onset AD., the angiostatic effects of endorepellin in vivo are mediated by a specific interaction of endorepellin with the alpha2beta1 integrin receptor., Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis., TT genotype showed significantly increased risk for urolithiasis than TG and GG genotypes., Examine association between perlecan SNPs and intracranial aneurysms in Japanese cohort., the angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association, The perlecan was prominently immunolocalised in the cartilaginous vertebral body rudiments and to a lesser extent within the foetal intervertebral disc., These data highlight the potential role of perlecan oxidation, and consequent deregulation of cell function, in vascular injuries by myeloperoxidase-derived hypochlorous and hypobromous acids., Endorepellin caused a widespread reduction in phosphorylation of key receptors involved in angiogenesis & a concurrent increase in phosphatase activity in endothelial cells & tumor xenografts., there might be no association between perlecan gene polymorphism and spinal muscular atrophy type I disease., in contrast to IA, HSPG2 and CSPG2 do not associate with AAA., These findings suggest that the HSPG2 gene is involved in neuroleptic-induced tardive dyskinesia (TD) and higher expression of HSPG2, probably even after antipsychotic treatment, and may be associated with TD susceptibility., perlecan plays an indispensible role in endothelial cell proliferation and acts through a mechanism that involves subcellular localization of p27., FGF2 and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan which modulate the growth factor activities, perlecan followed virtually identical immunolocalisation pattern to type II collagen in foetal joint tissue, but a slightly divergent pattern in adult tissues; evidence indicates perlecan is a marker of chondrogenic cells in prenatal cartilages, Domain V of perlecan, a known alpha2 integrin ligand, inhibits brain amyloid-beta neurotoxicity in an alpha2 integrin-dependent manner., Ameloblastoma cells proliferate and are differentiated by capturing perlecan differentially with alpha-dystroglycan and integrin beta1, respectively, endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic activity, association of the HSPG2 intronic SNP, rs2445142, with tardive dyskinesia susceptibility was demonstrated., TGF-beta(1)-induced perlecan deposition may enhance attachment of migrating airway smooth muscle cells (ASMC) in vivo and thus may be a mechanism for ASMC layer hypertrophy in chronic obstructive pulmonary disease, The perlecan fragment LG3 is a novel regulator of obliterative remodeling associated with allograft vascular rejection., activity mediated release of LG3/endorepellin into the circulation may represent a biological mechanism for the known inverse association between physical activity and cancer risk/survival, The C-terminal fragment of the extracellular matrix component perlecan (domain V, DV) has been shown to be increased in arteriovenous malformation of the brain., Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways, Report immunolocalization of fibrillin-1/perlecan in human fetal intervertebral disc., we suggest that the LG3 fragment of endorepellin could be associated with IgA nephropathy severity and might be related to pathogenesis of IgA nephropathy ., This study shows for the first time that mast cells secrete and process the extracellular proteoglycan perlecan into fragments containing the endorepellin C-terminal region that regulate angiogenesis and matrix turnover., Based on genetic analysis of patients with BA and zebrafish, GPC1 appears to be a BA susceptibility gene. These findings also support a role for Hedgehog signaling in the pathogenesis of BA, Endorepellin binds through its proximal LG1/2 domains to VEGFR2 and inhibit VEGFA-dependent endothelial migration., role for perlecan in chondrogenic and osteogenic events which drive discal development and ossification of the vertebral bodies., The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2)., [review] Perlecan domain V reached the infarcted brain tissue and peri-infarct brain regions because a transient middle cerebral artery occlusion model allowed for vascular reperfusion to the stroked brain region after 1 h of experimental occlusion., No association has been found between polymorphisms of rs251124 and rs3767137 loci of CSPG2 and HSPG2 genes and intracranial aneurysm in the selected population., Urinary perlecan laminin G-like 3 peptide and Ig kappa light chains were decreased in IgA nephropathy., endorepellin glycoforms may be highly specific and sensitive biomarkers for the differentiation of mucinous from nonmucinous pancreatic cysts., Data suggest that cancer cell-derived exosomes use heparan sulfate proteoglycans (HSPGs) for their internalization and functional activity, which significantly extends the emerging role of HSPGs as key receptors of macromolecular cargo., this study hypothesizes the transcriptional control of the HSPG2 gene in mast cells to synthesize these transcripts supports their stimulatory and specific role in wound healing and tissue regeneration., Perlecan synthesized by smooth muscle cells differs from that synthesized by endothelial cells by possessing different signaling capabilities and thus differential modulation of cell adhesion, proliferation and growth factor signaling., The perlecan is the primary ECM molecule comprising intraepithelial stroma of the junctional epithelium, in which leukocytes may migrate on ECM scaffolds in intercellular space toward the surface of the gingival sulci or pockets., We conclude that enzymatic processing of perlecan in the BM or territorial matrix by MMP-7 as occurs in the invasive tumor microenvironment acts as a molecular switch to alter PCa cell behavior and favor cell dispersion and invasiveness., Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis., Rare variants in the HSPG2 gene potentially contribute to the idiopathic scoliosis phenotype in a subset of patients with idiopathic scoliosis, Knockdown of agrin and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin., As five of the seven missense mutations in Schwartz-Jampel syndrome affect domain III of perlecan, domain III is likely to be essential for secretion of perlecan into the extracellular space.,
OFFICIAL_GENE_SYMBOL HSPG2,
OMIM_DISEASE Dyssegmental dysplasia, Silverman-Handmaker type, Schwartz-Jampel syndrome, type 1,
SP_COMMENT disease:Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH) [MIM:224410]. The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage., disease:Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1) [MIM:255800]; a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses., function:This protein is an integral component of basement membranes. It is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. It serves as an attachment substrate for cells., online information:Perlecan entry, PTM:N- and O-glycosylated; contains three heparan sulfate chains., similarity:Contains 1 SEA domain., similarity:Contains 11 laminin EGF-like domains., similarity:Contains 22 Ig-like C2-type (immunoglobulin-like) domains., similarity:Contains 3 laminin G-like domains., similarity:Contains 3 laminin IV type A domains., similarity:Contains 4 EGF-like domains., similarity:Contains 4 LDL-receptor class A domains., subunit:Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1., tissue specificity:Found in the basement membranes.,
integrin subunit alpha 2(ITGA2) integrin subunit alpha 2(ITGA2) Related Genes Homo sapiens
CHROMOSOME 5,
CYTOBAND 5q23-q31,
ENSEMBL_GENE_ID ENSG00000164171,
GENERIF_SUMMARY Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines., Reduction in integrin alpha 2 is related to changes seen during immortalization and malignant progression, The C807T polymorphism of integrin alpha2 gene in Suzhou Han population was different from that observed in other populations., Trimucytin, a collagen-like snake venom protein, activates platelets independent of I-domain within alpha2 subunit of alpha2beta1 integrin., the rGPIa/IIa-collagen interaction dominates the adhesion of rGPIa/IIa-Ib alpha-liposomes to the collagen surface at low shear rates; the rGPIa/IIa-collagen and rGPIb alpha-VWF interactions synergistically support liposome adhesion at high shear rates., Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., initial adhesion of endometrial cells to mesothelium is not mediated by alpha(2)beta(1)integrin, findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought, role of the GP Ia C807T/G873A polymorphism as a risk factor for thrombosis in Behcet disease, R-Ras promotes focal adhesion formation by signaling to FAK and p130(Cas) through a novel mechanism that differs from but synergizes with the alpha2beta1 integrin., genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy, twins developed ischaemic strokes and were shown to be homozygous for the alpha2 807T allele, linkage with extracellular signal-regulated kinase is functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells, Data show that NADPH oxidase activation production of reactive oxygen species are involved in the increase of alpha2beta1-integrin plasma membrane expression in Caco-2 cells stimulated with type IV collagen., role of polymorphisms in cardiovascular thrombotic disease [review], signaling through both constitutively expressed alpha2 integrin and Matrigel-induced alpha3 integrin expression is required to acquire a differentiated phenotype in Caco-2 cells., capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation., adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated in platelets, results of a case-control study involving 180 stroke patients and 172 controls do not support a role for the integrin alpha2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke, Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit., role in inhibiting Fas-mediated apoptosis in T-lymphocytes, There were significant differences in the distribution of T and C alleles between myocardial infarction and control groups., human platelet deposition on collagen depends on the concerted interplay of several receptors, results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling, Since the platelet alpha2 C807T gene polymorphism is associated with alpha2beta1 receptor density on the platelet surface, the level of alpha2beta1 on platelets may be an additional factor affecting Glanzmann's thromboasthenia clinical expression., virus attachment to alpha(2) integrin on the cell surface was found to result in integrin clustering, which can give rise to signaling and facilitate the initiation of the viral entry, VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis., alpha2beta1 integrin has a role in endorepellin-induced endothelial cell disassembly of actin cytoskeleton and focal adhesions, alpha2beta1 integrin and GPVI regulate stress fiber formation in megakarocytes, the primary actin structures needed for cell contraction, alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides., ILK regulates alpha 2 beta 1 in HEL cells, is activated in platelets and associates with beta 1-integrins, the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., alpha2807TT genotype of the platelet membrane integrin alpha2beta1 is associated with premature onset of early fetal loss. It appears that this risk factor does not induce the pathomechanism, but modulates the course of fetal loss, Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction., Alpha2beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin; while alpha2beta1 is also an important transducer for type I collagen., Binds to vimentin, but this association is lost after prolonged adhesion of endothelial cells to collagen., individual effect of each polymorphism located either in the coding or promoter sequence of the alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density, analysis of platelet glycoprotein I(b)alpha and integrin alpha2beta1 polymorphisms in diverse populations, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1, the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, alpha2beta1 and signaling via autocrine mediators facilitate and amplify the GPVI procoagulant activity of fibrillar and non-fibrillar collagens, Integrin alpha-2 gene polymorphisms is associated with breast cancer, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, Our results did not show the causative relationship between the existence of platelets GP Ia mutations and venous system thrombosis in the women in labor., Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., The Platelet surface integrin, alpha 2-collagen interaction is an early step associated with platelet adhesion and activation and plays an important role in arterial thrombosis., Common polymorphism (C807/T807), affecting the GPIa gene expression, in the development of oral cancer., malignant phenotype of pancreatic cancer on type I collagen is mediated specifically by the alpha2beta1 integrin, the Pro33 isoform of purified integrin alphaIIbbeta3 has increased fibrinogen and prothrombin binding, Genetic polymorphism C807T of platelet glycoprotein Ia increases the risk for premature myocardial infarction. It is also an independent predictor for the release of sCD40L during acute MI and persists 1 year after event., Acquisition of multiple antitumor drugs was accompanied by a drastically reduced expression of alpha2beta1 in the adenocarcinoma cells., This meta-analysis does not support an association between the C807T polymorphism of ITAG2 gene and stroke., The ectopic expression of TM4SF5 in Cos7 cells reduced integrin signaling under serum-containing conditions, but increased integrin signaling upon serum-free replating on substrates., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies., Results show that alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells., Our findings support the view that C807T polymorphism of the GPla gene is not a significant risk factor for CAD, either alone or in combination with other major cardiovascular risk factors., results demonstrate differential modes of regulation of Dok1 and Dok2 in platelets, and raise the possibility that Dok2 plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3, C807T/G873A polymorphisms, but not T837C, are associated with higher platelet reactivity and residual platelet activity after treatment with anti-platelet agents, glycoprotein Ia 807C/T and 873G/A dimorphisms were not shown as risk factors for VTE, activated EGF receptor transiently modulates integrin alpha2 cell surface expression and stimulates integrin alpha2 trafficking via caveolae/raft-mediated endocytosis, pancretic cancer cells attach to 3D type I collagen scaffolds in an alpha2beta1-specific manner, Adhesion of breast cancer cells through the VLA integrins alpha2beta1 and alpha5beta1 was significantly reduced by an apoptosis-inducing natural triterpenoid, dehydrothyrsiferol (DT), when studied on low amounts of extracellular matrix., both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, study indicates that the GPIa 807 C/T polymorphism does not represent a risk factor for Buerger's disease itself, but could be associated with premature onset of this disorder in predisposed individuals, findings suggest an important role of integrin alpha2beta1, alpha3beta1, and alpha5beta1 in the architectural characteristics of ameloblastomas and adenomatoid odentogenic tumor, genetic variability within ITGA2 may confer risk for ischemic stroke independent of conventional risk factors., LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, There is no indication that the presence of 807C/T polymorphism is present in platelet glycoprotein Ia gene and a risk factor for retinal vein occlusion., CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells, thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2., analysis of Src and C-terminal Src kinase interactions in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton, Our results do not support an independent association between the 807C/T polymorphism and stroke of undetermined etiology., The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an extracellular matrix-dependent and integrin-mediated manner., Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were found to be associated with the symptoms and recurrence of ischemic stroke., Platelet membrane glycoprotein Ia variations may have an important impact on aspirin resistance., Initiation of the signal requires two collagen receptors, alpha2beta1 integrin and discoidin domain receptor (DDR). Each receptor propagates signals through separate pathways that converge to up-regulate N-cadherin., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, collagen and a jararhagin-derived disintegrin peptide competitively bind to the integrin alpha2-I domain, alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes, The data suggest that phosphoenolpyruvate -dependent decrease of collagen biosynthesis in cultured human skin fibroblasts may undergo through depression of alpha(2)beta(1) integrin and IGF-IR signaling., Integrin alpha2beta1 may promote migration and invasion of neuroblastoma cells., These results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of enterotoxin function and rotavirus pathogenesis, further distinguishing this viral virulence factor from other microbial enterotoxins., 807C/T polymorphism of glycoprotein Ia (GPIa) gene were associated with higher risk of ischaemic stroke in atrial fibrillation, Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., SEMA3A suppression of tumor cell migration is dependent on alpha2beta1, the expression of which is stimulated in breast tumor cells by an autocrine SEMA3A pathway., analysis of distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens., ITGA2 807C>T polymorphism may be associated with reduced colorectal cancer risk., NO targets activation-dependent adhesion mediated by alpha(2)beta(1), possibly by reducing bioavailability of platelet-derived ADP, but has no effect on activation-independent adhesion mediated by GPVI, analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1, The increase in human platelet antigen, HPA-5b allelic frequency in Hepatitis C infection may indicate a possible association between HCV infection and HPAs., alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., Increased expression of integrin alpha2 and the increased response to TGF-beta1 of hereditary gingival fibromatosis (HGF) fibroblasts may be related to the excessive collagen deposition in HGF patients., Nox1 knockdown led to a loss of directional migration which takes place through a RhoA-dependent alpha2/alpha3 integrin switch., nucleotide substitution at position 2235 induces a Q716H amino acid change in the GPIa mature protein that causes Fetal/neonatal alloimmune thrombocytopenia., alpha2-integrin expression and Rho kinase activity are regulated by protein kinase signaling cascades upon activation of alpha7 nicotinic receptor, A GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation., Altogether these data suggest that integrins alpha2 and alpha v beta 3 do not play a major role in the rotavirus entry process., a central role for alpha2beta1 integrin in experimental and developmental angiogenesis, AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression., genetic polymorphisms in ITGA2 and P2RY1 combine with plasma VWF, In a Croatian population, the HPA-5 allele frequencies are 5a-0.895 and 5b-0.105., TM4SF5 in hepatocytes negatively regulates integrin alpha2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin alpha2 during cell spreading on and migration through collagen I environment, SHP-1 coprecipitates with integrin alpha2. A novel functional interaction between the integrin alpha2 subunit and SHP-1 is described., TGF-beta-mediated up-regulation of the expression of the integrin subunits alpha(2) and alpha(6) is mainly mediated in MSC by Smad2., in its entry strategy human echovirus 1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor, Collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and this effect is mediated by the interaction of collagen with integrin alpha2beta1., provide the first proof that talin binding is sufficient to activate and extend membrane-embedded integrin alphaIIbbeta3, thereby resolving numerous controversies and enabling molecular analysis of reconstructed integrin signaling., Data suggest that integrin alpha(2)beta(1), glycoprotein Ib and vWf interactions with collagen I and III contribute to platelet adhesion under high shear flow., the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes, Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function., Measurement of thrombus height after specific receptor blockade or use of altered proportions of peptides indicates a signaling rather than adhesive role for glycoprotein VI, and primarily adhesive roles for both alpha(2)beta(1) and the VWF axis, Androgens increased INT alpha1 and alpha2 subunits in tubuloepithelial cells and in healthy labial salivary glands., Single-nucleotide polymorphism in ITGA2 is associated with coronary atherosclerosis., a mutation in alphaIIbbeta3 integrin may have a role in Glanzmann thrombasthenia [case report], The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., alpha2beta1 integrin may be a major regulatory molecule in Th17 cell functions., The extracellular matrix rigidity affects the osteogenic outcome of mesenchymal stem cells through mechanotransduction events that are mediated by alpha(2)-integrin., Domain V of perlecan, a known alpha2 integrin ligand, inhibits brain amyloid-beta neurotoxicity in an alpha2 integrin-dependent manner., Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions., alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival, Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population., molecular forces of the alpha2beta1 integrin-collagen interaction, Expression of laminin beta1 and integrin alpha2 is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy., in endothelial cells, ligation of alpha2beta1 and alpha6beta1 integrins induces the Notch pathway, and we disclose a novel role of basement membrane proteins in the processes controlling tip vs stalk cell selection, Single nucleotide polymorphisms of integrin alpha-2 gene is not associated with colorectal cancer., PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis, endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic activity, Findings do not support the influence of the IRGA2807T allele in the development of retinopathy in type 2 diabetes., A vicinal thiol-containing population of alphaIIbbeta3 provides redox sensitive sites for regulation of alphaIIbbeta3., Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1., data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88, Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces., Rapid initiation of collagen-induced platelet aggregation may be associated with the platelet membrane GPIa T807 allele, which may be important in unstable angina pectoris pathogenesis., Data suggest that the ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer., CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands, Single-nucleotide polymorphisms in ITAG2 is associated with chronic kidney disease in Type 2 diabetes., Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase)., The disturbance of alpha2beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation., Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., Inflammation can up-regulate the expressions of Integrin alpha2beta1 and CD133 in benign prostatic hyperplasia tissue., Platelets bearing even one minor allele of integrin alpha2 534K show attenuated adhesion to decorin but not to collagen I., a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route, study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells, This evidence indicates that host cell ITGA2 might be involved in interacting with Cryptosporidium during infection., Data suggest that monoclonal antibody J19 is a potentially powerful tool for both studies on alpha(4)beta(7) activation mechanism and development of novel therapeutics targeting the activated lymphocyte expressing high affinity alpha(4)beta(7)., Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin., Patients with idiopathic sudden sensorineural hearing loss had a higher prevalence of the 807T thrombophilic polymorphism of ITGA2. There was a significant correlation between the 807TT homozygous genotype and a low probability of recovery., Collagen receptors alpha(1)beta(1) and alpha(2)beta(1) integrins are involved in transmigration of peripheral blood eosinophils, but not mononuclear cells through human microvascular endothelial cells monolayer, Integrin alpha2 is identified to be a novel EZH2 target by chromatin immunoprecipitation and short hairpin RNA analysis., Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation., findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population, study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation, data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone., An integrin alpha2 C807T polymorphism is associated with an increased risk of P. vivax-induced severe thrombocytopenia., Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation., HPA-5 typing discrepancy reveals an Ile503Leu substitution in platelet GPIa (alpha2 integrin)., PRL-3 plays a critical role in ovarian cancer tumorigenicity and maintaining the malignant phenotype. PRL-3 may inhibit c-fos transcriptional regulation of integrin alpha2 signaling., show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function, results suggest integrin alpha2 promotes osteoblast proliferation, study reports a functional and structural characterisation of the alpha2 I domain E318W mutant; E318W I domain A interacts with 2 collagen chains similar to wild-type I domain (high-affinity mode; E318W I domain B makes favorable interactions with only one collagen chain (low-affinity mode), Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT., Integrin alpha2beta1 and integrin alpha3beta1 suppress anoikis in undifferentiated cells., The Integrin alpha2 2 gene C807T polymorphism may be a susceptible predictor of the risk of ischemic stroke., glycoprotein Ia C807T polymorphism is associated with idiopathic sudden hearing loss., Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive., ITGA2 +807 gene polymorphism is not associated with susceptibility to CsA-induced GO., These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways., The alphaII b tail sequences distal of GFFKR participate in talin-mediated inside-out alphaII b beta3 activation through its steric clashes with beta3 -bound talin, It plays a role in regulation of leukocyte migration to a site of inflammation., The alpha2beta1 integrin mediates T-acute lymphoblastic leukemia cell migration through collagen in ERK and p38 MAPKs-dependent manner, Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543, ITGA2 is downregulated 39-fold by silencing of laeverin in trophoblasts, reducing cell migration and invasion., diabetic retinopathy is associated with ITGA2 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension., Carbohydrate-to-carbohydrate interactions between alpha2,3-linked sialic acids on alpha2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells., A highly bone metastatic RANKL-overexpressing prostate cancer cell line, LNCaP(RANKL)used as a model to study increased adhesion of prostate cancer (PCa) cells to collagens and found 3-D suspension culture and in vivo PCa tumor growth restore AR through downregulation of AP-4, enhancing integrin alpha2 expression and adhesion to ColI which is rich in bone matrices., This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1., EZH2-silenced cells the signaling activity of the de-repressed ITGalpha2 is able to increase cofilin phosphorylation, which in turn reduces cell migration., CD34 and CD49b are cell surface markers that can be used to enrich a subpopulation of leiomyoma cells possessing stem/progenitor cell properties., Polymorphism of HPA- 5 is probably a risk factor for carotid atherosclerosis complicating T2DM., HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I., Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship, Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer., The Glycoprotein Ia C807T polymorphism might be a risk factor for the development and relapse of Acute Coronary Syndrome, blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow, Integrin alpha 2 and alpha 4 Yxxphi motifs interact with the endocytic clathrin adaptor, AP2 complex., PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs., Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b and LAG-3 (CD223) on CD14(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.,
OFFICIAL_GENE_SYMBOL ITGA2,
OMIM_DISEASE Glycoprotein Ia deficiency,
SP_COMMENT domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage., function:Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix., polymorphism:Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD)., similarity:Belongs to the integrin alpha chain family., similarity:Contains 1 VWFA domain., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.,
integrin subunit alpha 5(ITGA5) integrin subunit alpha 5(ITGA5) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q11-q13,
ENSEMBL_GENE_ID ENSG00000161638,
GENERIF_SUMMARY alternative pathway of pro-alpha(v) processing involving MT1-MMP, The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits., role in mediating adhesion and migration of activated cycling CD34+ hematopoietic progenitor cells onto fibronectin, Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast, Central role of alpha5beta1 integrin in vascular development in mouse embryos and embryoid bodies., TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression, The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro., results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., B. pertussis FHA up-regulates ICAM-1 expression on respiratory epithelial cells through interaction of its RGD site with host cell VLA-5 integrin, and that PT impairs this response, Elevated expression of IL-8 (and not PTHrP) by MDA-MET cells is a phenotypic change that may be related to their enhanced ability to metastasize to the skeleton., integrin alpha5beta1 extracellular domain controls rhoA activity, Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, identification of binding site in gamma C-domain of fibrinogen, alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, The structural conformation of this protein, complexed wigh integrin beta1, complexed with fibronectin, is examined., Disulfide bonding patterns of the integrin alpha 5 chain are demonstrated; new insights into a second bond between the heavy and light chains of alpha 5 are described., Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Role of alpha4, alpha5, and alphav integrin receptors--which are central to mediating interactions with these domains of FN--in regulating ssquamous cell carcinoma migration., findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, Data show that squamous cell carcinoma cells escape suspension-induced, p53-mediated anoikis by forming multicellular aggregates that use fibronectin survival signals mediated by integrin alpha(v) and focal adhesion kinase., integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., The integrin, alpha 5 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., the alpha5 integrin subunit has a role in the induction of apoptosis triggered by FGFR2 activation in osteoblasts, and a Cbl-dependent mechanism is involved in the coordinated regulation of cell apoptosis induced by alpha5 integrin degradation, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, alpha3, alpha5, and alpha6 beta1 integrins are expressed in ductal cells at 8 weeks, before glucagon- and insulin-immunoreactive cells bud off in fetal pancrea., ITGA5 mediates engraftment of GCSF-mobilized stem cells., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, one mechanism by which IGFBP2 activates IGFBP2-induced cell mobility is through its interaction with integrin alpha5 and this interaction is specifically mediated through the RGD domain on IGFBP2, binding of CXCL12 to its receptor leads to enhanced expression of alpha5 and beta3 integrins, Alpha5beta1 (VLA-5) integrin is a major galectin-1-glycosylated counterreceptor involved in immune developmental synapse formation., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, activities for cell spreading and migration for the alpha5 subunit carrying only three potential N-glycosylation sites (3-5 sites) on the beta-propeller were comparable with those of the wild type, integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, These findings suggest that interaction with fibronectin through integrin alpha5 plays an important role in human extravillous trophoblast invasion., surface micron-scale topography modulates alpha(5)beta(1) integrin binding and FAK activation, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, Interaction of alpha-toxin with alpha5beta1-integrin and overproduction of TNF-alpha may contribute to destruction of epithelial cells during S. aureus infection., Modulation of cell adhesion is a normal physiological action of PTHrP, mediated by increasing integrin gene transcription., This study identified the beta1 integrins on primary smooth muscle cells that fibulin-5 interacts with, and showed that failure of fibulin-5 to activate these receptors limits cell spreading, migration and proliferation., OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest possible participation of alpha5beta1 integrin in the mechanism of local invasion of ameloblastomas, KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta, There is low expression of the proteins and mRNA of ME491/CD63 and integrin alpha5 in ovarian cancer. The lower the pathological differentiation is, the more significant the loss of expression is and the more likely metastasis is., Protein expression of ITGA5 decreased at labour and expression of these molecules was also observed in primary cultured human uterine SMCs., Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Integrin alpha5 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., analysis of important residues within the central turn motifs present in the cytoplasmic tails of integrin alphaIIb and alphaV subunits, data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin., Both integrins, v3 and v5, are involved in the glioma cell radioresistance through the integrin-linked kinase (ILK) and the small GTPase RhoB, at least by regulating the radiation-induced mitotic cell death., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell, The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., TM4SF5 facilitates angiogenesis of neighboring endothelial cells through VEGF induction, mediated by cooperation between TM4SF5 and integrin alpha(5) of epithelial cells, findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III., This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, inhibition of the alpha5beta1 integrin reduces lymphangiogenesis in inflamed airways after M. pulmonis infection, The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, Erythroid differentiation stimulated by hemin was greatly enhanced when K562 cells were induced to adhere to Fibronectin by activating VLA-5 with TNIIIA2, a peptide derived from tenascin-C., H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., These results suggest that alpha(5)-integrin up-regulation induced by E-cadherin loss under hypoxia has a crucial role in regulating the migration of extravillous trophoblast cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., Induction of alpha5-integrin expression is a key determinant by which inhibitors of TGFbeta type-I receptor kinase and VEGF synergistically promote angiogenesis., upregulated expression in lung adenocarcinoma cells following bacterial infection, new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., These findings not only reveal that ITGA5 is required for osteoblast differentiation of adult human mesenchymal stromal cells (hMSCs) but also provide a targeted strategy using ITGA5 agonists to promote the osteogenic capacity of hMSCs., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., This study demonstrates that an important antiinflammatory aspect of glucocorticoids is regulating the expression and function of alpha5 integrin., 17beta-estradiol enhances alpha(5) integrin subunit gene expression through ERalpha-Sp1 interaction and reduces cell motility and invasion of ERalpha-positive breast cancer cells., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1, Transfection of the alpha1,2-fucosyltransferase gene into ovarian carcinoma-derived cells brought about elevated expression of integrin alpha5beta1 with Le(Y)., Integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim., EGF may influence proliferative vitreoretinopathy by promoting integrin-alpha(5) expression and subsequent proliferation and migration of retinal pigment epithelial cells., in the presence of alphavbeta3-integrin Rac1 is not required for tumor angiogenesis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction., Interaction between IGFBP2 and integrin alpha5 accelerates cell adhesion, and this, in turn, enhances JNK-mediated glioma cell migration., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Downregulation of ITGA5 is associated with multiple myeloma., Findings indicated the diverse roles of ITGA5 expression in breast cancer cells., The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., We propose that alpha(5)beta(1) integrin, which is associated with cholesterol-rich microdomains at the host cell surface, is required for NOD1 recognition of peptidoglycan and subsequent induction of NF-kappaB-dependent responses to H. pylori., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., investigation of role of ITGA5 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 calcium channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., RNA interference-mediated knockdown of CD49e (alpha5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion., Integrin 5 1 facilitates cancer cell invasion through enhanced contractile forces, In cultured intervertebral disc cells, fibronectin fragment increased the expression of MMP9,MMP13m alpha 5 and beta1 integrin via the alpha5beta1 integrin receptor., Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., S100A4 protects gastric cancer cells from anoikis by regulation of alphav and alpha5 integrin expression, which sheds a novel light for the role of S100A4 in cancer metastasis, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, The expression of the alpha5 gene in human uveal melanoma cell lines, was characterized., elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., The endoproteolytic cleavage of alphav subunits is necessary for alphavbeta5/beta6 integrin to control alpha2beta1 function and could thus play an essential role in colon cancer cell migration., Data suggest that colorectal cancer (CRC)-derived integrin alphavbeta6 is involved in the establishment of tumor immune tolerance in local tissues., growth defects in mesenchymal stromal cells in myelodysplastic syndromes were significantly correlated with decreases in CD44 adhesion molecules and CD49e., study here indicated that integrin alphaVbeta3 had lower affinity when the ADMIDAS was mutated, WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Rv2468c engaged integrin VLA-5 (alpha5beta1) on CD4+ T cells through its FN-like RGD motif GRDGSPK., alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1., ZEB2 was found to activate integrin alpha5 and vimentin promoters by interacting with and activating transcription factor Sp1, suggesting that cooperation between ZEB2 and Sp1 represents a novel mechanism of mesenchymal gene activation during epithelial-mesenchymal transition, uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., show further that MYC represses transcription of both subunits of alphavbeta3 integrin, and that exogenous expression of beta3 integrin in human breast cancer cells, betaig-h3 co-localized with integrin alpha5beta1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule., Specific adhesion of megakaryoblasts to fibronectin via both alpha5- and alpha4-integrin molecules and phorbol 12-myristate 13-acetate (PMA) is essential for pro-platelet-like formation of megakaryocytes., Data indicate the role of CYR61 and alpha(V)beta5 integrin as proteins that cooperate to mediate cancer cell migration., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., PKCalpha constitutes a crucial component of the integrin alphav-mediated pathway(s) that promote p53 relocalization and melanoma survival., Tauroursodeoxycholic acid induces in perfused rat liver and human HepG2 cells the rapid appearance of the active conformation of the beta subunit of alpha5beta1 integrins, followed by an activating phosphorylation of extracellular signal-regulated kinases., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., Co-expression of c-Met and Integrin alpha5beta1 has mechanical significance in the early stages of human gastric cardia adenocarcinoma., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., miR-148b controls malignancy by coordinating a novel pathway involving over 130 genes and, in particular, it directly targets players of the integrin signaling, such as ITGA5, ROCK1, PIK3CA/p110alpha, and NRAS, as well as CSF1, High Integrin alpha5beta1 expression is associated with metastasis of colorectal cancer., Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., Calreticulin, integrin-alpha5, and TGF-beta1 expression was increased in atrial tissue in patients with AF and was related to AF type, suggesting that calreticulin is involved in the pathogenesis of AF in VHD patients., The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells., These findings support a direct role for Survivin in melanoma metastasis, which requires alpha5 integrin and suggest that inhibitors of alpha5 integrin may be useful in combating this process, Data indicate that nuclear integrin alphav monomer in T4-exposed cells, but not integrin beta3, bound to promoters of specific genes that have important roles in cancer cells., MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, the identification of ITGA5 -E2/3 splice variant as potential novel adverse prognostic marker for low-risk AML, We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma, loss of BRM epigenetically induces C/EBPbeta transcription, which then directly induces alpha5 integrin transcription to promote the malignant behavior of mammary epithelial cells, 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Integrin alpha5beta1 overexpression is associated with lymph node metastasis and vascular invasion in cervical cancer., our results identify a novel regulatory pathway involving the interplay between ZO-1, alpha5-integrin and PKCepsilon in the late stages of mammalian cell division., High integrin alphaVbeta6 expression is associated with liver metastasis in colorectal cancer., Herpes simplex virus gH/gL sufficed to elicit type I IFN and NF-kappaB activation via alphavbeta3 integrin in epithelial and neuronal cell lines., these results establish that GP IIb/IIIa and alphavbeta3 integrins are essential mediators of shear flow-induced cancer cell mechanotransduction, Integrin alpha5-FAK signaling pathway controls the proliferation of bladder smooth muscle cells in response to cyclic hydrodynamic pressure., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data show the molecular model of the complex of activated protein C (APC) with alphaVbeta3 integrin obtained by protein-protein docking approach., Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., RhoC facilitates tumor cell invasion and promotes subsequent metastasis, in part, by enhancing integrin alpha5beta1 trafficking, We have demonstrated for the first time a new molecular pathway that connects TMPRSS4 and integrin alpha5 through miR-205 to regulate cancer cell invasion and metastasis, Overexpression of integrin alpha v is closely associated with metastasis and progression of nasopharyngeal carcinoma., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, phenotype of mice with alpha5-erythroid deletions was similar to controls, especially after stress. These outcomes seem to reconcile divergent prior views on the role of alpha5-integrin in erythropoiesis., CCN2 and inflammatory cytokines form a functional negative feedback loop in NP cells involving interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins that may be important in the pathogenesis of disc disease, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., In the presence of both 9-cis-retinoic acid and troglitazone, cell surface alpha5 subunit expression was restored to levels comparable to vehicle treatment alone., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., Data show that thyroid hormones induce mitogen-activated protein kinase (MAPK) via integrin alphavbeta3 in bone marrow-derived cells from multiple myeloma (MM)., demonstrate that alpha5 integrin turnover is dependent on fibronectin matrix assembly, Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., Data indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Mesodermal expression of integrin alpha5beta1 regulates neural crest development and cardiovascular morphogenesis., Data indicate that influenza A virus H1N1 infection activated alphavbeta6 integrin-dependent transforming growth factor beta (TGFbeta) activity in immortalized bronchial epithelial cells (iHBEC)., PAI-1 inhibits activation of VEGFR-2 by VEGF by disrupting a vitronectin-dependent proangiogenic binding interaction involving alphaVbeta3 and VEGFR-2, Data indicate that alpha5 integrin (ITGA5) is a functional target of miroRNA miR-26a-induced anoikis in hepatocellular carcinoma (HCC) cells., Twist1 and AP-1 cooperatively upregulate integrin alpha5 expression to induce invasion and the epithelial-mesenchymal transition.Twist1 expression positively correlates with integrin alpha5 expression in human colorectal cancers., we detected higher activity of AKT (p = 0.011) and FAK (p = 0.054), higher integrin alpha5 expression (p = 0.052) and lower PTEN expression in primary cells from patients with bone metastasis compared to nonmetastasizing cells., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Integrin alphanubeta6-mediated MMP-9 secretion facilitates pericellular matrix degradation at high cell density, promoting invasive growth of colonic neoplasms., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway., Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Collagens considerably suppressed alpha5 gene expression in CECs, suggesting that during wound, Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1., Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer, The present study has revealed an integrin- and membrane lipid raft-dependent mechanotransduction mechanism by which atheroprone flow causes endothelial dysfunction., integrin alpha5 might play important roles in the progression of esophageal squamous cell carcinoma, knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased,
OFFICIAL_GENE_SYMBOL ITGA5,
SP_COMMENT function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
integrin subunit beta 1(ITGB1) integrin subunit beta 1(ITGB1) Related Genes Homo sapiens
CHROMOSOME 10,
CYTOBAND 10p11.2,
ENSEMBL_GENE_ID ENSG00000150093,
GENERIF_SUMMARY the linkage between beta1 integrin and actin may be differentially regulated by its tyrosine and serine/threonine phosphorylation in normal and cancerous breast cells., Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling, Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction, both VEGF-induced PI 3-kinase activation and beta(1) integrin-mediated binding to fibronectin are required for the recruitment and activation of PKC alpha., Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines., Although cytoplasmic splice variants do not change the ligand-specificity of a beta 1 integrin, this review explains how clustering of different splice variants triggers signaling pathways that lead to a different cellular response., beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican, These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells., Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain, Data demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins such as CD151 are palmitoylated, and that palmitoylation is not required for cd151-alpha3beta1 integrin association., Activated Notch4 inhibits angiogenesis, role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding, mechanical stress to the beta1-integrin subunit in osteoblasts revealed that cyclic forces of 1 Hz were more effective to stimulate the cellular calcium response than continuous load, beta1 and beta2 integrins activate different signalling pathways in monocytes., Inv-induced cell death was mediated via beta1-integrins since Inv bound to the beta1-integrin subunit (CD29), anti-beta(1)-integrin antibodies blocked Inv-induced cell death and Inv-induced cell death was absent in two beta1-integrin- cell lines., Beta1 integrin triggering affects leukemic cell line sensitivity to natural killer cells, Evidence for distinctive signaling of CD82- and beta1 integrin-mediated costimulation at the transcriptional level of IL-2 gene., There is a desensitization of IL-8-mediated p42/p44 MAPK signaling in response to ligation of the alpha5beta1 integrin in PMNL. There may be an interplay between integrin and chemokine signaling during PMNL migration through the extracellular matrix., Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines, Ionizing radiation strongly induced the expression of functional beta1-integrin and ILK in the two lung cancer cell lines, A549 and SKMES1., mediates adhesion of osteosarcoma to the core region of thrombospondin 1 (alpha 4 beta 1 integrin), role in regulating beta 1 integrin-dependent leukocyte adhesion, results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation, VLA4 integrin activation by chemokines requires cholesterol, role of Rap1 GTPase for Mn(2+)- and antibody-induced VLA-4-mediated cell adhesion [VLA-4], Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance., Data show that, in vitro, under physiological conditions, CD98 is constitutively associated with beta1 integrins regardless of activation status., Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., ITGB1 activated by ERK1/2, p38 MAPK after hypoxia, data suggest that overexpression of beta 1-integrin confers resistance to apoptosis in hepatoma cells via a MAP kinase dependent pathway, regulation of alpha4beta1 integrin function in melanoma cells and T cells by ligands of CD47, role in mediating pro-angiogenic activity of CYR61, beta1 integrin engagement is required for bombesin-dependent pro-MMP-9 activation in prostatic cancer cells, initial adhesion of endometrial cells to mesothelium is not mediated by beta1 integrins but attachment to collagen IV and collagen I, which are present in the submesothelial extracellular matrix, is mediated by beta1 integrins, molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes, findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought, Temporal gene expression profile of precursor B leukemia cells induced by ITGB1 identifies pathways regulating B-cell survival., results are consistent with an essential role for beta(1) integrins in maintenance of cardiomyocyte viability and interaction with extracellular matrix, Data show that the expression of the PAINS-13 epitope depends on CD9 association with alpha(6)beta(1) integrin., Data show a novel mechanism by which ECM regulates membrane-type 1 matrix metalloproteinase (MT1-MMP) association with beta1 or alphavbeta3 integrins, thus modulating its internalization, activity, and function on human endothelial cells., beta1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by its gC1q domain, integrin alpha5beta1-mediated control of the levels of integrin alphaVbeta3 is important for the distribution of focal contacts, the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1, integrin beta1 cytoplasmic peptides self-associate; role in beta1 integrin clustering and formation of focal adhesions, beta(1) integrin has a role in the syndecan-4 pathway for cell spreading, along with PKCalpha and RhoA, Overexpression of AKT2/protein kinase Bbeta leads to up-regulation, increased invasion, and metastasis of human breast and ovarian cancer cells., that the expression of beta(1C) integrin, a very efficient inhibitor of cell proliferation, may be modulated by the maternal microenvironment and may play a fundamental role in mediating trophoblast outgrowth and migration during pregnancy., Results establish, for the first time, mutation as a mechanism by which integrins can contribute to neoplasia., Alterations in alpha5beta1 levels induced by TGF-beta are mediated at least in part through the induction of CTGF in glomerular mesangium, beta1 integrin has a role in selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A, thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylation was blocked by the antibodies to integrins alpha 5 beta 1 and alpha v beta 3, directly linking their migration and signaling components, determination of crystal structure in complex with an antibody Fab fragment, Data show that NADPH oxidase activation production of reactive oxygen species are involved in the increase of alpha2beta1-integrin plasma membrane expression in Caco-2 cells stimulated with type IV collagen., endostatin competes with fibronectin/RGD cyclic peptide to bind alpha 5 beta 1 integrin, This study revealed detailed topography of integrins in malignant tumours derived from intercalated acinar segment of salivary gland which might be useful their diagnosis , especially of fine-needle aspiration products or from incisional biopsy., expression of beta1 integrin subunit is responsible for differentiation-associated changes in cells behavior in terminally differentiated oral keratinocytes, capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation., adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated in platelets, identification of binding site in gamma C-domain of fibrinogen, Decidual beta1 integrin and FAK participate in this final step of implantation., alpha 5 beta 1 and alpha v beta 3 are both important but cell-specific fibrillin-1 receptors, integrin alpha 6 beta 1 binds to CCN1, Alpha4beta1 integrin has a role in cell adhesion, VEGFR-1 secreted by endothelial cells interacts with the alpha 5 beta 1 integrin, visualized the head region of integrin alpha 5 beta 1 in an inactive (Ca2+-occupied) state, and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences, cells overexpressing beta 1-integrin exhibited increased proliferation in response to hepatocyte growth factor., AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients., identify intracellular signals involved in integrin BETA1-initiated internalization of S. aureus, in beta-thalassemic patients, significant reduction of CD49d, CD29 and CD71 antigen expression was found in peripheral blood nucleated red cells, upon treatment with phorbol esters, K562 cells become adherent and permissive for parvovirus B19 entry, which is mediated by alpha 5 beta 1 integrins, but only in their high-affinity conformation, alpha6beta1 integrins have roles as thrombospondin receptors in microvascular and large vessel endothelial cells, Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunit., S-phase delay induced by overexpression of integrin beta1 subunit caused by decrease of protein kinase B phosphorylation and subsequent increases of p21(cip1) and p27(kip1) proteins. May be involved in unoccupied alpha5beta1 because of lack of ligands., Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin., In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels., The beta1-integrin-ligand disengagement resulted in capillary disruption and stimulated p38 MAPK and extracellular signal-regulated kinase activity., beta1 integrin/FAK-mediated signaling on osteoblasts could be involved in ICAM-1- and RANKL-dependent osteoclast maturation, results suggest that beta1 integrin is a common receptor for AfaD invasins and that additional AfaD-type-specific receptors exist, The structural conformation of this protein, complexed wigh integrin alpha5, complexed with fibronectin, is examined, Reduced beta1 integrin-mediated cell adhesion of HME cells to the substratum during mitosis may be induced by beta1 integrin phosphorylation at threonines 788-789 and its reduced ability to link with the actin cytoskeleton., role in ganglioside GM3 blocking of epidermal growth factor receptor, following priming of human neutrophils with lipopolysaccharide or tumor necrosis factor alpha (TNF-alpha), addition of formyl-Met-Leu-Phe (fMLP) results in a "stimulated", sepsis-like, four- to fivefold rise in CD49d expression, the failure of beta1 integrin dephosphorylation at threonines 788 and 789 may be due to a significant reduction in the PP2A-A expression in tumor cells, integrin beta1 interacts with galectin 1, Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin., human platelet deposition on collagen depends on the concerted interplay of several receptors, Data demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of putative pancreatic progenitors on Netrin-1., ligand-binding specificities of integrin alpha3beta1 and alpha6beta1, Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo., alpha3beta1 integrin binding to laminin-5 depends on its proteolytic processing, beta1C integrin splice variant is transcriptionally regulated in human prostate adenocarcinoma, integrin alpha4beta1 is induced by p53 and has a role in B-cell chronic lymphocytic leukemia drug resistance, Key role of the regulation of beta 1C integrin expression in the pathogenesis of endometrial proliferative diseases, results suggest that a direct interaction occurs between the Adenovirus penton base protein and the integrin receptor alpha3beta1 in vitro and in vivo, results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes, alpha3beta1, alpha4beta1 and alphaVbeta1 integrins may play an important role in the implantation process, Data show that stimulation-dependent recycling of integrin beta1 is regulated by ARF6 and Rab11, and also requires the actin cytoskeleton in an ARF6-dependent manner., results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling, Alpha4beta1 is an important endothelial cell receptor for mediating motility and proliferative responses to thrombospondins and for modulation of angiogenesis., beta1 integrin maturation and transport to the cell surface is regulated by low density lipoprotein receptor-related protein-1, alpha(v)beta(1) supports fetal beta-cell migration and could play an important role in early motile processes required for islet neogenesis, Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells, beta I-like and alpha I domain activation involves structurally analogous alpha7-helix axial displacements., beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin, Data suggest that the early arrest of tumor cells in the pulmonary vasculature through interaction of alpha3beta1 integrin with laminin-5 in exposed basement membrane provides a basis for cell arrest during pulmonary metastasis., EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions, findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation., The marked decrease in integrin alpha5beta1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of smooth muscle cells, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells, Overexpression of integrin beta(1)modifies the response of I(Ca)to beta-adrenergic receptor stimulation., conformational activation of VLA-4 by inside-out signaling is independent of and additive to reduction-regulated integrin activation, very late antigen-4 affinity is modulated by shear, alpha2beta1 integrin has a role in endorepellin-induced endothelial cell disassembly of actin cytoskeleton and focal adhesions, role in chemotaxis in conjuction with plasmin, Increases in IGF-IR decrease beta1 integrin expression, and enhance cell migration in neuroblastoma cells., alpha2beta1 integrin and GPVI regulate stress fiber formation in megakarocytes, the primary actin structures needed for cell contraction, Calu-1 lung cancer cells use primarily a beta1-integrin-mediated intracellular tyrosine phosphorylation phenomenon as the key regulatory mechanism for its binding advantage to Coll IV matrix., alpha 3 beta 1 integrin is necessary and sufficient for maximal keratinocyte survival on laminin-5, alpha4beta1 integrin on sickle reticulocytes is a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides., cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin, ILK regulates alpha 2 beta 1 in HEL cells, is activated in platelets and associates with beta 1-integrins, integrin alpha5beta1 participates in the activation of both VEGFR-3 and its downstream PI3 kinase/Akt signaling pathway, which is essential for fibronectin-mediated lymphatic endothelial cell survival and proliferation., 16K expression inhibits beta(1) integrin surface expression and spreading on matrix by a novel mechanism that results in reduced levels of functional beta(1) integrin, alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis, The integrin, beta 1 was expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor., caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes, Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen, Data demonstrate that type I collagen synergistically enhances platelet-derived growth factor (PDGF)-induced smooth muscle cell proliferation through Src-dependent crosstalk between the alpha2beta1 integrin and the PDGF receptor beta., Activation of PI3K following beta1-integrin engagement on human CD34+ cells results in subsequent phosphorylation of PYK2, and is required for the recruitment of the PI3K/PYK2 complex to beta1-integrins at the cell surface., Integrin beta1 subunit was an important constituent receptor subunit for mediating chemotactic pseudopod protrusion of hepatocellular carcinoma cells to laminin., demonstrates a cooperative role between alpha5beta1 and alpha4beta1 integrins and suggests that interactions between the Hep II domain and alpha4beta1 integrin could modulate the strength of cytoskeleton-mediated processes in the trabecular meshwork, ICAM-1 molecules interacted only with group B Streptococcus(GBS)-III liquor 90356 strain while beta1 integrin interacted with GBS-III liquor 90356 and GBS-V blood 90186 invasive strains, VEGF-C and VEGF-D are ligands for the integrin alpha9beta1, The expressive fluorescent intensity of integrinbeta(1) in G(1) phase SMMC-7721 cells was depressed more significantly than the values of S phase., analysis of transcriptional regulation of beta1 integrin expression in endometrium and endometrial neoplasms, Data show that the recombinant Scl protein p176 promotes adhesion and spreading of human lung fibroblast cells through an alpha2beta1 integrin-mediated interaction., BMP-2 upregulates the expression of alphavbeta integrins, and these integrins, in turn, play a critical role in BMP-2 function in osteoblasts, Results indicate that CD151 association modulates the ligand-binding activity of integrin alpha3beta1 through stabilizing its activated conformation not only with purified proteins but also in a physiological context., JAM1 regulates epithelial cell morphology and beta1 integrin expression by modulating activity of the small GTPase Rap1., Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands., Alpha5beta1 integrin is required for up-regulation of IL-1 beta-dependent airway smooth muscle secretory responses by fibronectin., integrin beta1 function is modulated by CD98 in polarized epithelial cells, VEGF and alpha4beta1 integrin have roles in chemokine-induced motility on and through endothelium in chronic lymphocytic leukemia cells but not in normal B lymphocytes, Alpha5beta1-mediated adhesion of Ntera2 neuronal cells to fibronectin decreased apoptosis in response to serum withdrawal., integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, Interacts with vimentin, but this association is lost after prolonged adhesion of endothelial cells to collagen., Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation., Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway, activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion, KSHV gB can activate VEGFR-3 on the microvascular endothelium and modulate endothelial cell migration and proliferation via an interaction between the alpha3beta1 integrin and the VEGFR-3 receptor, findings suggest that only some P. aeruginosa strains can target Fn and their natural receptors alpha5beta1 integrins for adherence to A549 cells, matrix-derived mechanical forces sensed by beta1 integrin are capable of modulating ILK activity which regulates fibroblast viability via an Akt-dependent mechanism, alpha3beta1 integrin binding results in a suppression of the interleukin-1 signaling pathway leading to the activation of NF-(kappa)B, alpha2 gene may act in combination to modulate variations in platelets alpha2beta1 receptor density, FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways, analysis of platelet glycoprotein I(b)alpha and integrin alpha2beta1 polymorphisms in diverse populations, platelet membrane integrins alpha IIb(beta)3 (HPA-1b/Pl) and alpha2(beta)1 (alpha807TT) polymorphisms may have a role in premature myocardial infarction, Expression pattern of integrin subunits in the human fetal pancreas (8-20 weeks fetal age) and the relevance of beta1 integrin function for insulin gene expression and islet cell survival., PDGFR-dependent cell detachment is induced by S1P via inhibition of beta1 integrin in HEK293 cells, Three intracytoplasmic motifs of the tail of VLA-4 beta 1 subunit differentially regulate VLA-4-mediated adhesive functions under static adhesion and shear flow conditions., integrin alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 binding to osteopontin is controlled by specific structural motifs that are recognized by extracellular proteases, analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1, the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, phenotypic conversion and reversion of bladder cancer cells is controlled by a glycosynapse 3 microdomain through GM3-mediated interaction of alpha3beta1 integrin with CD9, Results provide evidence for a novel species of beta1 integrin on the cell surface, which does not appear to be associated with any alpha chain., alpha2beta1 and signaling via autocrine mediators facilitate and amplify the GPVI procoagulant activity of fibrillar and non-fibrillar collagens, IFN-gamma attenuates epithelial wound closure by microtubule-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of focal adhesion complexes and cell migration., mapping of the N-glycosylation sites on the beta1 integrin to better understand the potential effects of differential sialylation on integrin structure/function, The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells., Cells deficient in beta1 integrin can bind human ADAM12 via beta3 integrin., the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia, suggests beta1-integrins as critical regulators of cell survival after radiation-induced genotoxic injury, beta 1 integrin has roles in cell adhesion and migration in development and metastasis [review], beta1 integrin is critical for the alveolar morphogenesis of a glandular epithelium and for maintenance of its differentiated function, Outside-in signaling through integrin alpha2beta1 triggered inside-out activation of integrin alphaIIbbeta3 and promoted fibrinogen binding. (alpha2beta1 AND integrin alphaIIbbeta3, isolated beta1 cytoplasmic domain expression induces caspase-independent detachment of viable endothelial cells and that death is secondary to detachment (i.e. anoikis), Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain, Our data show that alpha3beta1 integrin function may be altered by glycosylation, that both subunits contribute to these changes, and glycosylation may be considered a newly found mechanism in the regulation of integrin function., Expression of integrins alphavbeta1, alphavbeta3, and alphavbeta5 in cerebral arteriovenous malformations and cavernous malformations. (Integrins alphavbeta1, alphavbeta3, and alphavbeta5), Results suggest that loss of E-cadherin function is linked to regulation of cell-cell and cell-matrix adhesion, based in part on cell surface expression of alpha2, alpha3 and beta1 integrins., Platelets, by binding via P-selectin to PSGL-1 on monocytes, induce up-regulation and activation of beta1 and beta2integrins and increased adhesion of monocytes to activated endothelium., The Integrin beta1 thrombogenic polymorphism and FcgammaRIIA expression could play a role in platelet sensitivity to collagen in type 2 diabetes., The integrin receptors of tenascin (TN) and fibronectin (FN) may be involved in cell processes such as growth, adhesion, migration and apoptosis., These results indicate that the alpha2beta1 and alphaVbeta1 integrin signaling pathway may be critical components of neurodegeneration in Alzheimer's disease., CCN2/CTGF enhances chondrocyte adhesion to FN through direct interaction of its C-terminal CT domain with FN, and alpha5beta1 is involved in this adhesion., decreased podocyte expression of alpha3beta1 integrins is closely related with podocyte depletion, glomerular sclerosis, and daily protein loss in patients with primary focal glomerulosclerosis, facilitates reovirus internalization and suggest that viral entry occurs by interactions of reovirus virions with independent attachment and entry receptors on the cell surface., IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer., This study supports matrix-induced clustering of alpha3beta1 integrin promotes uPAR/alpha3beta1 interaction; potentiating cellular signal transduction pathways culminating in activation of uPA expression and enhanced uPA-dependent invasive behavior., EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization, urokinase plasminogen receptor domain III controls a functional association with alpha5beta1 integrin and tumor growth, Beta1-integrin subunit is identified as a new gastrin-regulated gene in human pancreatic cancer cells., Data indicate that integrin beta1 plays a major and complex role in osteoblastic differentiation modulated by either surface microarchitecture or 1alpha,25(OH)2D3., RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR., Slug regulates integrin alpha3, beta1, and beta4 expression and cell proliferation in human epidermal keratinocytes, integrin alpha3beta1 is a receptor for the alpha3NC1 domain and transdominantly inhibits integrin alphavbeta3 activation, Data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells., These results are consistent with the conclusion that the anti-tumor activity of angiocidin arises from its ability to ligate collagen and alpha2beta1 on endothelial cells and tumor cells., Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer., The formation of dendrites is shown to require the interaction between the beta1-integrin (CD29) on the surface of the DCs and fibronectin in the extracellular matrix., Data show that the integrin beta1 repertoire in renal cell carcinoma is different from normal proximal tubule cells, and that valproic acid acts on all investigated integrin subtypes to restore the receptor pattern typical for non-malignant cells., extracellular matrix fragments produced by apoptotic EC initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/SFK (Src and Fyn)/phosphatidylinositol 3-kinase (PI3K)-dependent pathway, This is the first demonstration that the integrin beta1 tail can regulate centrosome function, the assembly of the mitotic spindle, and cytokinesis., Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies., Salivary progenitor epithelial cell survival is beta 1 integrin-dependent., This is the first report of direct binding of a Mycobacterium tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function, the internalization of AAV2 in mammalian cells might follow a "click-to-fit" mechanism that involves the cooperative binding of heparan sulfate and alpha5beta1 integrin by the AAV2 capsids, Results show that alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells., results indicate that exported alpha-toxin inhibits the adhesion and internalization of S. aureus by interfering with integrin-mediated pathogen-host cell interactions., integrin alpha5beta1 plays a pivotal role in the hypotonic stress-induced but not in the lysophosphatidic acid-induced responses, comparison of DOCK2 and Vav1 involvement in CXCL12-promoted Rac activation and alpha4beta1-dependent human T cell adhesion indicated a more prominent role of Vav1 than DOCK2, IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry, Primary human mesenchymal stem cells are able to induce self-renewing divisions of hematopoietic progenitor cellsby a beta(1)-integrin-dependent mechanism., Results show that coculture with ECs enhances VSMC adhesion and spreading by up-regulating beta(1)-integrin expression and activating the PI3K/Akt pathway. Interaction between ECs and VSMCs serves a role in vascular homeostasis and remodeling., decrease of beta(1)D-integrin & FAK in ischemic cardiomyopathy; loss of beta(1)Dintegrin-FAK-complex in ICM paralleled by reduced AKT activity supporting in vitro data showing role of intact integrin function in anti-apoptotic signaling & cell survival, CEA-mediated signaling involves clustering of CEA and co-clustering and activation of the alpha5beta1 and associated specific signaling elements on the internal surfaces of membrane microdomains, integrins alpha5beta1 and alphaV are inhibited by lebectin and lebecetin snake venom lectins, IL4-induced FBGC are characterized by the expression of alphaMbeta2, alphaXbeta2, alpha5beta1, alphaVbeta1, alpha2beta1, and alpha3beta1, which indicates potential interactions with fragments of C3, fibrin(ogen), fibronectin, Factor X, and vitronectin, alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells, Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner., The integrin activation level, assessed by binding of soluble collagen to the alpha2beta1 integrin, was reduced upon cell treatment with DT. The TS2/16, an anti-beta1 activating monoclonal antibody was able to rescue DT-treated cells from apoptosis., High affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells., These experiments identify a new compound that can interfere with biological processes by inhibiting microdomain formation and also identify beta1 integrin as a potential mediator of signaling by GSLs., Lubrol-RAFTs probably represent the platform for tumor-promoting ephrin-B2-integrin-beta1 interaction, which could become an interesting target for future antitumoral therapies, integrin beta1 has a role in inhibiting cell proliferation by preventing the Skp2-dependent degradation of p27(Kip1) via PI3K pathway, both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, These results suggest that engagement of beta1 integrins on systemic lupus erythematosus T cells could induce FAK-mediated signaling and subsequent CD40L expression and proliferation., These results indicate that binding of the alpha3beta1 integrin results in a suppression in the activation of the IL-1 induced intracellular signaling pathway from JNK to AP-1., Integrin alpha5beta1 is critical for the chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2, and this induction is ligand dependent., findings suggest an important role of integrin alpha2beta1, alpha3beta1, and alpha5beta1 in the architectural characteristics of ameloblastomas and adenomatoid odentogenic tumor, In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression., Data show that in bullous pemphigoid, expression of beta1 was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis., This study identifies alpha2 beta1 integrin as an important regulatory pathway of IFN-gamma expression and provides novel insights into the signaling mechanisms of integrin costimulation in T cells., The VCAM-1/very late activation antigen 4 adhesive system critically mediates endothelial progenitor cell adhesion to cultured rheumatoid arthritis fibroblasts and to rheumatoid arthritis synovial tissue, LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins, support a model in which KAI1/CD82 attenuates the maturation of the beta1 integrin precursor and thereby suppresses cell migration, T-cadherin may modulate cell-matrix adhesion in basal keratinocytes as well as invasive potency in squamous cell carcinoma by regulating surface level of beta1 integrin, talin 1 is a versatile VLA-4 affinity regulator implicated in both spontaneous and chemokine-triggered rapid adhesions to VCAM-1., results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment, No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy., Beta1 and alpha3 integrins are functionally important receptors for type 1 pili-expressing bacteria within the urinary tract and possibly at other sites within the host., CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells, Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway., beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation., CXCR4 contributes to renal carcinoma cells (RCC) dissemination and may provide a novel link between CXCL12 expression and integrin beta1 triggered RCC adhesion to the vascular wall and subendothelial matrix components, Np-1 confers a growth and survival advantage to pancreas cancer cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness., The process of dynamic integrin regulation may be an important part in tumour cell migration strategy, switching the cells from being adhesive to becoming motile and invasive., identification of alpha3beta1 as the predominant integrin and laminin receptor in glioma cells, and as a brain invasion-mediating integrin, IGF-I receptor and beta1-integrin signaling may play an important role in protective effect of hyaluronic acid on interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, TGF-beta2 promoted human lens epithelial cell adhesion and migration in vitro. Integrin beta1 and integrin-mediated signaling are necessary for TGF-beta2-promoted adhesion and migration in human lens epithelial cells., The expression of beta1-integrin was found to be significantly reduced in photoaged skin and ratios of the expressions of involucrin to beta1-integrin were increased 2.6-fold only in elderly subjects., These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal., These results strongly suggest that enhanced expression of alpha3beta1 integrin on hepatocellular carcinoma cells is directly involved in their malignant phenotypes such as invasion and metastasis., The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an extracellular matrix-dependent and integrin-mediated manner., These data demonstrate that activation of Epac1 increases integrin activity and integrin-dependent homing functions of progenitor cells., tPA induces LRP-1 tyrosine phosphorylation, which in turn facilitates the LRP-1-mediated recruitment of beta1 integrin and downstream ILK signaling, thereby leading to myofibroblast activation., results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion, Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells., Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins., The physiologically relevant organ culture assay employed here is a potential research tool for exploring whether targeted stimulation of beta1 integrin-mediated signalling is a suitable candidate for human hair loss management., Through interactions with alpha5beta1 integrin and thrombospondin, CD47/IAP may modulate chondrocyte responses to mechanical signals. (Integrin, alpha5beta1), Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin., Integrin beta1 subunit plays a significant role in TGF-beta1-induced fibronectin deposition on human airway smooth muscle., Integrin beta 1 transgene is involved in the phagocytosis of certain bacteria, including group B streptococcus and Staphylococcus aureus, and critically regulates phagosome maturation through Rac expression., The shear-induced G(2)/M arrest and corresponding changes in G(2)/M regulatory protein expression and activity were mediated by alpha(v)beta(3) and beta(1) integrins through bone morphogenetic protein receptor type IA-specific Smad1 and Smad5., Beta1 integrin/Fak/Src signaling translates into integrated mediating functions of p38b activation and regulation of Bcl-2 homologs by PI3-K/Akt-1 and MEK/Erk, consequently determining their requirement (or not) for survival., B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44., H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin-JNK pathway, HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, Hypersialylated beta1 integrin is endogenously expressed in human astrocytoma cell lines., Show a critical role of PKCdelta in the regulation of renal carcinoma cell migration, which seems to be caused by affecting the expression and activity of beta1 integrins and focal adhesion kinase., data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins, alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes, key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines., Lumican induces cell migration by activating ERK 1/2 signaling and ERK 1/2 stimulates expression of integrin beta1., The data suggest that phosphoenolpyruvate -dependent decrease of collagen biosynthesis in cultured human skin fibroblasts may undergo through depression of alpha(2)beta(1) integrin and IGF-IR signaling., CD151 regulates integrin alpha3beta1 functions in two independent aspects, TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation[review], Osteoblast-derived BMP-2 act through Akt and ERK, which in turn activates IKK alpha/beta and NF-kappaB, resulting in the activations of beta1 and beta 3 integrins and contributing the migration of prostate cancer cells., VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients, study reports that T cell costimulation by the integrin VLA-4 (alpha4beta1) required SLP-76 domains implicated in microcluster assembly, Integrin alpha2beta1 may promote migration and invasion of neuroblastoma cells., Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation, Caveolin-1-dependent beta1 integrin and fibronectin endocytosis plays a critical role in fibronectin matrix turnover., SPARC-mediated mobilization of adipose stromal (stem) cells through its effect on alpha5beta1 integrin complex provides a functional basis for the regulation of white adipose tissue body composition by SPARC., These results indicate that NSP4 interaction with integrin alpha1 and alpha2 is an important component of enterotoxin function and rotavirus pathogenesis, further distinguishing this viral virulence factor from other microbial enterotoxins., The ability of alpha5 beta1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology., Generated high throughput platform to examine interactions of type I collagen receptor alpha(2)beta(1) and fibronectin receptor alpha(5)beta(1) with peptide ligands to evaluate the effects of integrin cross-talk on adhesive responses., LPS or peritoneal dialysis effluent stimulated the adherence of T cells to mesothelial cells, a process mediated by the integrins alpha6beta1 and alpha4beta1, Chemotherapy-induced overexpression of integrin b1 in some multiple myeloma patients upregulates LRP expression in bone marrow cells, inducing antineoplastic drug resistance., Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions., integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, This study demonstrates an important role of the dynamic raft reorganization induced by CD44 clustering in eliciting the matrix-derived survival signal through the CD44-SRC-integrin beta1 axis ., human umbilical vein endothelial cells adhere to immobilized CXCL4 through alphavbeta3 integrin, and also through other integrins, such as alphavbeta5 and alpha5beta1, gal-3 binds directly and preferentially to unsialylated, as compared with alpha2-6-sialylated, beta1 integrins, EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins, Results suggest that HAb18G/CD147 enhances the invasion and metastatic potentials of human hepatoma cells via integrin alpha3beta1-mediated FAK-paxillin and FAKPI3K-Ca(2+) signal pathways., Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling., The mRNA levels of integrin beta1 and ILK protein were significantly higher in laryngeal carcinoma than in the surrounding tissue and vocal cord polyps., These data data suggest that, in migrating intestinal epithelial cells, beta(1)-integrin is internalized via a dynamin-dependent lipid raft-mediated pathway., Preferential downregulation of beta1-integrin expression on progenitor cells can reduce the tethering forces to BM components, thus facilitating their egress to the peripheral circulation during an allergic inflammatory response., SEMA3A suppression of tumor cell migration is dependent on alpha2beta1, the expression of which is stimulated in breast tumor cells by an autocrine SEMA3A pathway., tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges., analysis of distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens., These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., GnT-V is expressed in human extravillous trophoblast and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin., The integrin beta1-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas., VLA-4, a heterodimer of CD49d and CD29, is the most important adhesion molecule for cell-adhesion-mediated drug resistance in multiple myeloma cells., uPAR and beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA in lung cancer cells., ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins, Our results argue for the involvement of galectin-1 in the PKCepsilon/vimentin-controlled trafficking of integrin-beta1, Overexpression of GluR1 positively correlated with glioma cell adhesion to type I and type IV collagen which was decreased in cells with blocking antibodies to beta1 integrin, NO targets activation-dependent adhesion mediated by alpha(2)beta(1), possibly by reducing bioavailability of platelet-derived ADP, but has no effect on activation-independent adhesion mediated by GPVI, analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1, The phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins., Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789., overexpression of ITGB1 may be related to resistance to chemotherapy in esophageal squamous cell carcinoma, These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth., Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a "vicious cycle" between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction., Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state., Suggest that the specific interaction of MCT4 with beta(1)-integrin may regulate cell migration through modulation of focal adhesions., mechanisms by which TF induces estrogen receptor alpha expression in breast cancer involve both PAR2 and beta(1)-integrin, Integrin-beta1 was overexpressed in oral leukoplakia, and may correlate to the proliferation of the dysplasia cells., TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., Functional live-cell imaging demonstrates that ITGB1 promotes type IV collagen degradation by breast and prostate cancer cells., alpha 3, alpha 6A, and beta 1 integrin expression in cancer cells at the invasive front are related to the mode of invasion and prognosis in oral squamous cell carcinoma, data suggest that alphavbeta1 integrin is a functional receptor for hMPV, Results suggest that prostaglandin E2 mainly induces the activation of beta(1)-integrins via the EP(2) receptor in human coronary arterial endothelial cells., Stress application to activated beta1 integrins increases Galphas recruitment and activates these large G proteins within focal adhesions, JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration., findings show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force, Expression of a genetic variant in the I-like domain of beta1 integrins does not affect normal epidermal homeostasis, but increases skin tumor susceptibility and influences tumor type in transgenice mice., High levels of VLA-4 is associated with mantle cell lymphoma., Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects, These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function, This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-extracellular matrix forces., The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp., Cdc42 activity is impaired in beta1 integrin-deficient T cells that form conjugates with antigen-presenting cells but is partially restored in the context of an antigen-specific synapse., Data showed that tumor-associated matrices induced PI3K and beta1-integrin dependent Akt/PKB activity in MDA-MB-231 cells., These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence., Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN., Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin., TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling., alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization, Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1)., alpha(2)-, alpha(3)-, and beta(1)-integrins and E-cadherin expression in normal human lung and bronchopulmonary sequestration and congenital cystic adenomatoid malformation were evaluated using Western blot and immunohistochemistry., Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins, Compared with open surgery, laparoscopy-assisted radical gastrectomy is not associated with a greater effect on the expression of ICAM-1 and integrin beta(1) in peritoneal mesothelial cells., These findings identify a novel role for alpha3beta1 integrin in promoting wound angiogenesis through a mechanism of crosstalk from epidermal to endothelial cells, and they implicate MRP3 in this integrin-dependent crosstalk., Results show that alphavbeta6- and alpha5beta1-integrin-dependent activation of Rac1 was mediated through Eps8., The most potent CysLT(1) ligand, LTD(4), rapidly and significantly up-regulated alpha(4)beta(1) and alpha(5)beta(1) integrin-dependent adhesion of both primitive and committed hematopoietic progenitor cells, These findings support a role for FLNa-beta1 integrin as a mechanosensitive complex that bidirectionally senses the tension of the matrix and, in turn, regulates cellular contractility and response to this matrix tension., decreased expression on allograft T cells of healthy bone marrow donors following Granulocyte colony-stimulating factor pretransplant conditioning, LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor, H. pylori induces the expression of integrin alpha(5) and beta(1) and adhesion of the cells to fibronectin through PAR2 which is induced and may be activated by trypsin in H. pylori-infected gastric epithelial cells., heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts, The presence of the alpha11 integrin chain during early corneal development and the enhanced expression in scarred keratoconus corneas indicates that integrin chain is likely to play an important role in collagen deposition during corneal development, In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism., Data show that overexpression of CAR in human epithelial cells leads to increased basal activation of p44/42 MAPK and of beta1 and beta3 integrins, and that this is required for efficient Ad5 infection., Results describe the measurement of the force-dependent lifetimes of single bonds between a fibronectin fragment and an integrin alpha(5)beta(1)-Fc fusion protein or membrane alpha(5)beta(1)., these results highlight for the first time the considerable role of the integrin alpha6beta1 in glioma progression., Results assess uterine receptivity in women with unexplained infertility using beta1 integrin molecules VLA-4, -5, and -6 within endometrial tissue in comparison with fertile women., The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche, Integrin alpha5beta1 controls invasion of the studied cells via regulation of MMP-2 collagenase expression which can occur either through signaling pathways involving PI-3K, Akt, and Erk protein kinases and the c-Jun., A GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation., is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1], Interactions between type I collagen and beta1 integrins augment apoB secretion by Caco-2 cells., Expression of beta1 and beta3 integrins was detected mainly in basal keratinocytes in dermatitis herpetiformis and bullous pemphigoid., Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes, a central role for alpha2beta1 integrin in experimental and developmental angiogenesis, upregulated expression in lung adenocarcinoma cells following bacterial infection, Musashi-1 and beta1-integrin may be involved in human colorectal tumor carcinogenesis and progression., ECRG2 is involved in the regulation of cell migration/invasion through uPA/uPAR/beta1 integrin pathway., AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression., Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations., new homology model of human integrin alpha5beta1 supports an important function for D3-A3 loop residues Trp157 and Ala158 in the binding of antagonists., Among laminin-binding integrins, mast cells express alpha3beta1 (but not alpha6beta1, alpha7beta1, or alpha6beta4) integrins., Gal-3 promotes epithelial cell migration by cross-linking MGAT5-modified complex N-glycans on alpha3beta1 integrin., Integrins alpha3beta1 and alpha6beta1 are important cell surface receptors that mediate the chemotaxis of hepatocelluar carcinoma cells toward laminin., Integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 to mediate tumor invasion and metastatic processes., Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP, ERbeta affects integrin expression and clustering and consequently modulates adhesion and migration of breast cancer cells., although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration, Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation., Detecting intracellular Erk1/2 phosphorylation and IL-2 and IFN-g production, study confirmed that multiple signals, including VLA-4 engagement, are necessary for maximal T-cell activation beyond that induced via the TCR and CD28., VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival., differentiated placental multipotent mesenchymal stromal cells may contribute to blood vessel formation, and this activity depends on integrin alpha(5)beta(1), Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads., Macroscopic currents from HEK 293 cells expressing murine BK channel alpha-subunits (mSlo) are acutely potentiated following alpha5beta1 integrin activation., beta(1)-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients, Oscillatory shear stress induces osteoblast-like cell proliferation through activation of alpha(v)beta(3) and beta(1) integrins and synergistic interactions of FAK and Shc with PI3K, leading to the modulation of ERK and Akt/mTOR/p70S6K pathways., in its entry strategy human echovirus 1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor, results suggest that PRL-3's roles in motility, invasion, and metastasis in colon cancer are critically controlled by the integrin beta1-ERK1/2-MMP2 signaling, Targeting of integrin beta1 and kinesin 2alpha by microRNA 183., Induced integrin alpha5 and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest., Collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and this effect is mediated by the interaction of collagen with integrin alpha2beta1., Data show that potentiated and sustained adhesion to fibronectin via VLA-4 causally induces apoptosis also in various types of hematopoietic tumor cells., These results suggest that both gangliosides and beta1-integrin are required for maintenance of caveolae and plasma membrane domains., conserved NPXY and TT motifs play important roles in the tissue-specific function of integrin, Data suggest that integrin alpha(2)beta(1), glycoprotein Ib and vWf interactions with collagen I and III contribute to platelet adhesion under high shear flow., DSCs-expressed CD82 up-regulates the expression of TIMP1 in an autocrine manner and inhibits the invasiveness of human first-trimester trophoblast cells partly through the integrinbeta1/MAPK/MAPK3/1 signaling pathway, Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation., Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of integrins alpha5 and beta1., Increased uPAR expression promotes alpha(3)beta(1) integrin association, resulting in increased mitogen-activated protein kinase signaling and transcriptional activation, leading to the formation of more aggressive tongue tumors., the binding of filamin A to vimentin and protein kinase C epsilon is an essential regulatory step for the trafficking and activation of beta1 integrins and cell spreading on collagen, Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway., Data show that the L-plastin/integrin complex is regulated by mu-calpain cleavage and is not directly dissociated by calcium., Integrins may initiate the cellular response of osteocytes to dynamic fluid flow and may serve as mechanosensitive molecules in bone., The results demonstrate definitely that major quaternary rearrangements of beta1-integrin subunits occur in adherent cells and that conversion from a bent to extended form takes place at focal adhesions., Pancreatic beta cell mesenchymal transition and decline in insulin gene expression are induced by elements of the ECM, by b1-integrin ligation, and by signaling via Src, JNK, and ERK., The expression of Integrin beta1 decreases when the differentiation level of squamous cell carcinoma cells increase., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., Indicate that the integrin beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures., Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function., Inhibition of integrin beta1 reduced the adhesion forces of trophoblast cells to type I rat collagen or endothelial cells., Measurement of thrombus height after specific receptor blockade or use of altered proportions of peptides indicates a signaling rather than adhesive role for glycoprotein VI, and primarily adhesive roles for both alpha(2)beta(1) and the VWF axis, upon serum starvation, alpha(5)beta(1) integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta, The results suggest that the production of MMP-9 by MKN1 cells was potentiated by the alpha3beta1 integrin-laminin-5 interaction, which facilitated their invasion via degradation of the matrix., Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways., alpha4beta1-mediated tumor lymphangiogenesis promotes metastasis, Activation of ss1-integrin in human umbiilical vein endothelial cells (HUVEC) is specifically affected by depletion of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)., The authors identify beta(1) integrin, which is expressed by naive B cells of distinct lymphoid origin and by memory B cells from nasal mucosa-associated lymphoid tissue, as a mediator of increased susceptibility to infection by Epstein-Barr virus., Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion., up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions, Integrin beta 1 may play an important role in the development of hepatic fibrosis, hepatic cirrhosis and hepatocellular carcinoma., Data demonstrate that tumor necrosis factor (TNF)alpha activates the integrin alpha(5)beta(1) without altering total expression levels of beta(1) integrin on human umbilical vein endothelial cells., Prostate tissue-derived CD133+ cells exhibited a high level of expression of beta1 integrin, The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage non-small cell lung cancer patients, The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., Inhibition of beta1 integrin function rescued proliferation and cyclin E1 expression as well as c-Myc expression and Rb phosphorylation., when beta(1)A is unligated, beta(1)B is responsible for "integrin-mediated death" in human keratinocytes, Recombinant or microparticle-associated tissue factor stimulate endothelial cell proliferation through activation of the ERK 1/2 pathway, mediated through a novel mechanism requiring the interaction of exogenous TF with cell surface beta1-integrin., Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration., Eight different anti-integrin beta1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed., Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway., in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronectin and degraded in lysosomes, decreasing beta1 chain causes alphavbeta3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity., Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis., The HCMV gB-DLD protein bound to fibroblasts in a specific, dose-dependent and saturable manner that required the expression of an intact beta1 integrin ectodomain., alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance., The interplay between alpha5-integrin and sFn contributes significantly to tissue cohesion and, depending on their level of expression, can mediate a shift from liquid to elastic behavior., airway smooth muscle activation of plasminogen by uPA is accelerated in a collagen-rich environment in which the inhibitory effect of TGF-beta is attenuated in association with greater uPA expression induced via beta1-integrin signaling, Findings argue strongly that beta1-integrin can both potentiate CMG2-mediated endocytosis and serve independently as a low-affinity PA receptor., plays a key role in the pathogenesis of pustulosis Palmaris et Plantaris, Calcium regulates integrin beta1 activity and expression and cell migration of HaCaT cells., Inhibition of beta1 integrin expression by DNAzyme to beta1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro., The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration., our data indicate that CCR7 regulate cell adhesion and migration via beta1 integrin in metastatic squamous cell carcinoma of the head and neck, SIRPalpha facilitates cross-talk between the prolactin receptor (PRLr) and beta1 integrin and provides a basis for extracellular matrix regulation of PRLr action in breast cancer., Data confirmed reduced CD9 expression in MDS CD34+ and bone marrow mononuclear cells., U937 macrophage responses to the TLR2 ligand, Pam3CSK4, are dependent upon integrin alpha3beta1., the CCR7/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1, Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions., Data show E-cadherin molecular dynamics in vivo following perturbation of integrin signaling by inhibiting focal adhesion kinase (FAK) and Src., Data show that coculture of ALL cells with MSCs induced on the lymphoblast plasma membrane the expression of a signaling complex formed by hERG1, the beta(1)-integrin subunit, and the chemokine receptor CXCR4., Data suggest that up-regulation of integrin beta1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2., Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction., the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells, Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression., Both wild-type and internal tandem duplication (ITD)-FLT3 proteins co-immunoprecipitated with beta1 integrin and Pyk2 indicating the signal crosstalk between FLT3, beta1 integrin and Pyk2., Lewis y can influence the biological behavior of a tumor cell as an important composition of integrins alpha5 and beta1 by some signal pathway, such as promoting cell adhesion and migration., fibronectin promotes ovarian cancer invasion and metastasis through an alpha(5)beta(1)-integrin/c-Met/FAK/Src-dependent signaling pathway., Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions., Structural diversity in integrin/talin interactions., alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival, ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, investigation of role of ITGB1 in cancer, Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 channel current in human embryonic kidney cells (HEK293-T) expressing Cav1.2., Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors., Data show that interactions between beta1 integrin and ErbB4 occur in a spatiotemporally-regulated manner, and such interaction contributes to the integrin-dependent cell migration., Ameloblastoma cells proliferate and are differentiated by capturing perlecan differentially with alpha-dystroglycan and integrin beta1, respectively, expression of VLA-4 in PBMC of hemorrhagic fever with renal syndrome (HFRS) patients at different stages were higher than normal controls, except recovery stage; VLA-4 might play an important role in the immunopathological lesions of HFRS, These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways., High expression levels of CD151 and alpha6 promote invasiveness of HCC cells. Either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC., Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells., kindlin-2 promotes integrin b1 and b3 activation., expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype, IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection., The extra nuclear AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. Assembly of this ternary complex may control organ development and prostate cancer metastasis., Data suggest that integrin alpha6beta1 is an important cell surface receptor that mediates the adhesion of the SMMC-7721 hepatocellular carcinoma cell line to type IV collagen., stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream beta1 integrin function, Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation., High integrin beta 1 is associated with invasive lobular cancer in comparison with other breast tumor types., a novel mechanism by which beta1 integrin regulates matrix metalloproteinase-10 expression during lymphatic vessel remodeling, Significant to anoikis-related regulation, the delay in caspase-8 activation was accompanied by the maintenance of FAK Tyr397 phosphorylation, integrin beta1-associated FAK and a FAK/caspase-8 complex., Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of PDGF-BB signals., P-selectin, on eosinophil-associated activated platelets or acquired from plasma or from prior interactions with endothelial cells/platelets, activates eosinophil beta1 integrin, stimulating eosinophil adhesion to VCAM-1 and move to the airway in asthma., a direct interaction between the Oca-family member NadA and human beta1 integrins., in endothelial cells, ligation of alpha2beta1 and alpha6beta1 integrins induces the Notch pathway, and we disclose a novel role of basement membrane proteins in the processes controlling tip vs stalk cell selection, results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy., HOXD1 plays a significant role in endothelial cells functions by regulating the expression of ITGB1., Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing, Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8, Pancreatic stellate cells radioprotect pancreatic cancer cells through beta1-integrin signaling, The effect of SDF-1 on colorectal cancer cell signaling and urokinase-type plasminogen activator (uPA) expression is mediated by the CXCR4/beta1 integrin axis., maspin, uPAR, and beta1 integrin co-immunoprecipitate, suggesting a novel maspin-uPA-uPAR-beta1 integrin mega-complex that regulates mammary epithelial cell adhesion., these findings show that epithelial-mesenchymal transition and its down-regulated expression of E-cad circumvent breast cancer dormancy in part by facilitating beta1 integrin expression necessary for metastatic outgrowth., High serum ITGB1 is associated with gastric cancer., The results showed that overexpression of Id1 enhanced cell migration and increased beta1-integrin expression, In osteoblasts exposed to dexamethasone, ILK expression was slightly increased, whereas there was substantial reduction in that of beta1 integrin., Both DCC and integrin bindings interfere with microtubule binding to myosin X., Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1., data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88, Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces., Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation., beta1 integrin-mediated adhesion is upregulated during T lymphocyte extravasation by activating Galpha subunit-dependent inside-out signaling., MSC migration is controlled by CD73 & CD29, which in turn are regulated by mechanical stimulation of cells, elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin, Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway., Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins., when lung fibroblasts are attached to collagen matrix, the beta1 integrin/Src/PP2A-mediated 4EBP-1 regulatory pathway is activated, Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase)., The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells., Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators., These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration., SHARPIN inhibits the critical switching of beta1-integrins from inactive to active conformations., Data show that CD151 acts as an important player in the progression of HCC in an integrin beta1-dependent manner., In malignant melanoma, CD147/basigin regulates integrin beta1 signaling via the phosphorylation of focal adhesion kinase., There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples., Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles., ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration, Talin1 is required for inside-out activation of integrin beta1 during Bartonella henselae infection., Left ventricular assist device-induced reversed remodeling did not result in significant integrin protein expression, although changes in integrin mRNA expression suggested an adaptation to unloading., WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration., Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells., the integrin beta1 signaling pathway has an important role in regulating the nanofiber-induced fibroblast phenotypic alteration, examined integrin beta(1) , ECAD and rac1 expression in SCLC and analyzed the prognostic value of these markers, a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route, Results demonstrate differential effects of Snail and Slug in pancreatic cancer and identify the interplay between Rho signaling and beta1-integrin that regulates the scattering and migration of Snail- and Slug-expressing pancreatic cancer cells., Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., these data collectively indicate that beta1-integrin-related cell death is closely associated with EMT phenotypes and activation of the p53-p21 pathway is partly involved in the acquisition of resistance to apoptosis induced by beta1-integrin silencing., uPAR is an essential component of the network through which VEGF controls integrin redistribution and endothelial cell migration., study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells, IGFBP2 activates integrin beta1 and downstream invasion pathways. The IGFBP2/integrin/ILK/NF-kappaB network functions as a physiologically active signaling pathway in vivo by driving glioma progression., Recombinant expression plasmid integrin-beta1- shRNA can inhibit the expression of integrin-beta1 gene and suppress the invasion of pancreatic carcinoma cells in vitro significantly., HMGB-1 enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the RAGE receptor/PI3K/Akt/c-Jun/AP-1 signal transduction pathway., integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression, The expression of beta1-integrin in glia is crucial for the proper development of the cerebellar cortex, whereas its expression in granule neurons is dispensable for cerebellar development., Dephosphorylation of FAK upon inhibition of beta integrin resulted in dissociation of a FAK/cortactin protein complex. This, in turn, downregulated JNK signaling and induced cell rounding, leading to radiosensitization., our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis, The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer., analysis of the role of RICTOR in beta1 integrin-mediated cell survival and how receptor-specific mechanisms regulate phosphorylation of AKT at Ser473, Integrin beta1-mediated cellular adhesion to fibronectin confers drug resistance to mitomycin-C on bladder cancer cells. Knockdown of integrin beta1 may abolish the drug resistance phenotype and sensitize bladder cells to mitomycin-C., This study demonstrates that integrin beta1 mediates EGF-induced cell invasion in ovarian cancer., demonstrate with loss-of-function and rescue experiments that CD9 activates and MMP8 inactivates beta1 integrins and that both proteins associate with beta1 integrins in cells, The findings indicated that integrin a6b1 promotes the survival of brain endothelial cells by inhibiting prodeath signaling by TNF-R1, in part by inducing cellular FLICE inhibitory protein expression., Integrin b1/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial cells., cell surface protein disulfide isomerase colocalized with beta1 and beta3 integrins after dengue virus infection, pro-migratory effect of the non-cleaved form of ST6Gal I was dependent on integrin beta1 sialylation, crystal structure of the alpha5beta1 integrin headpiece fragment bound by an allosteric inhibitory antibody was determined at a 2.9-A resolution both in the absence and presence of a ligand peptide containing the Arg-Gly-Asp (RGD) sequence, The number of glycine residues in the PH domain is the key difference underlying the differential actions of cytohesin 2/ARNO and cytohesin 3/GRP1 in cell adhesion, spreading and beta1 integrin recycling., describe the generation of sCD154 mutants that lost their ability to bind CD40 or alphaIIbbeta3 and show that CD154 residues involved in its binding to CD40 or alphaIIbbeta3 are distinct from those implicated in its interaction to alpha5beta1, The live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton., Integrin beta1 mediates vaccinia virus entry through activation of PI3K/Akt signaling., Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways., Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin., beta1 integrins should sense the stimulation of fluid shear stress and thus activate ERK1/2 through activating of FAK., The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome., decreased GnT-V activity due to inflammatory cytokine induction in human monocytes resulted in enchancement of integrin alpha5beta1-dependent monocyte-vascular endothelium adhesion and transmigration, There is no association between platelet collagen receptor polymorphisms GP VI T13254C or GP Ia C807T (alpha2beta1Integrin) and premature acute myocardial infarction in the Iranian population., These data suggest that Dab2-mediated recruitment of EH domain proteins selectively drives the internalization of the Dab2 cargo, integrin b1., Kindlin-2 and talin head do not interact with one another but can bind simultaneously to the integrin beta(3) tail without enhancing or inhibiting the interaction of the other binding partner., The regulation of alpha4beta1-dependent adhesion and migration of myeloma cells by CXCL12-S1P combined activities might have important consequences for myeloma disease progression., alpha5beta1 integrin transgene demonstrates an important angiogenic role by promoting brain endothelial cell proliferation in response to cerebral hypoxia., Host cell kinases, alpha5 and beta1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells., found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit, Periostin had preferential binding to cholangiocarcinoma cells via ITGalpha5beta1 and blocking this receptor by either neutralizing antibody or siRNA could attenuate Periostin-induced invasion., Combination of CD29 and CD44 can be used as markers to enrich cancer stem cells in human squamous cell carcinoma with epithelial-mesenchymal transition., These findings indicate that integrin beta1 has a major impact on HNSCC prognosis through its regulation of metastasis., CD151 links alpha(3)beta(1)/alpha(6)beta(1) integrins to Ras, Rac1, and Cdc42 by promoting the formation of multimolecular complexes in the membrane, which leads to the up-regulation of adhesion-dependent small GTPase activation, Glycogen synthase kinase 3beta inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation., Tauroursodeoxycholic acid can directly activate intrahepatocytic beta integrins, which trigger signal transduction pathways toward choleresis., It was shown that mutations in the integrin beta1 tail NPXY motifs in the kidney produce phenotypes different from those seen in constitutive and skin-specific knock-ins., Provide further evidence that beta1 integrin can be a marker of poor prognosis in breast cancer., MMP-2 amplifies the motility of colon cancer cells, not only by digesting the extracellular matrix components in the vicinity of cancer cells but also by inactivating their major beta1 integrin receptors., Most actinic cheilitis cases showed reduced expression of integrin beta1 and superficially invasive squamous cell carcinoma lacked intergrin beta1 in the invasive front., Endoglin-mediated fibronectin/alpha5beta1 integrin and TGF-beta1 pathway crosstalk switched the respone to TGF-beta1 from a promoter to a suppressor of migration, inhibiting TGF-beta1-mediated apoptosis, and partially mediating developmental angiogenesis in vivo., In astrocytes transfected with a chimeric beta1 subunit, its activation is sufficient to cause centrosome assembly in the absence of cell adhesion., Data indicate that alpha3beta1 and the tetraspanin CD151 directly associate at the front and retracting rear of polarised migrating breast carcinoma cells., while alpha5beta1 integrin cross-linking contributes to the bacillus Calmette-Guerin response, it alone is insufficient to duplicate the full spectrum of bacillus Calmette-Guerin induced changes in urothelial carcinoma cell biology., EGF regulates alpha5beta1 integrin activation state in cancer cell lines through the p90RSK-dependent phosphorylation of filamin A., Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth., Examined the role of beta1 integrin in exocrine pancreatic structure and function. Compared with control pancreata, beta1 integrin-deficient pancreata showed reduced mRNA expression of extracellular matrix (collagen type Ialpha2, fibronectin and laminin) genes., Data show that TIMP-2-mediated inhibition of vascular endothelial cell permeability involves an integrin alpha3beta1-Shp-1-cAMP/protein kinase A-dependent vascular endothelial cadherin cytoskeletal association., Gal-3 expression enhances beta1 integrin-mediated cell adhesion and cell migration., The chemokine domain of fractalkine binds to integrins alpha4beta1 and alphavbeta3., Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation., NEU3 is a key regulator of the beta1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in renal cell carcinomas malignancy., Beta1 integrin is the main target for Cdc42-mediating interaction of cancer cells with endothelial cells and the underlying extracellular matrix, as exogenous beta1 integrin expression was sufficient to rescue the Cdc42-silencing phenotype., Expression of alpha and beta integrin subunits is increased on peripheral blood T cells in patients with asthma, study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation, Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced intracellular phosphorylation signaling, involving focal adhesion kinase-1 (FAK) and PI3 kinase (PI3K)-dependent Akt activation, Mechanotransduction through beta(1)-integrins, FAK and p38 is required for anti-inflammatory effects of steady shear stress., data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone., Data indicate that Slug siRNA suppressed the TGF-beta1-induced integrin alpha3beta1-mediated cell migration ability of squamous cell carcinoma HSC-4 cells., Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation., The role of beta1 integrins and of a beta1 downstream target, c-Jun amino-terminal kinase 1 (JNK1), in regulating radiation-induced apoptosis in prostate cancer was studied., Mechanical regulation of alpha5beta1 integrin-ligand interactions in a molecular mechanism for cell adhesion strengthening by cyclic forces., GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation., osteopontin, LAMB3 and ITGB1 played important roles in the occurrence and metastasis of lung cancer, thus provided important clues to understanding the molecular mechanism of metastasis., beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma., Aberrant expression of E-cadherin and integrin beta-1 is closely related to malignant transformation and hydatidiform mole development., a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported., Data suggest that ITGB1 is critical ligand to enhance cell-extracellular matrix contact force and thus promotes cell proliferation; ITGB1 knockdown affects leiomyomal cell spreading but not adhesion; ITGB1 may function in progression of leiomyoma., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, Timp1 is assembled in a supramolecular complex containing CD63 and beta1-integrins along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway., Integrin beta1 interacts with SPARC in prostate cancer cells and suppresses cell proliferation and migration., provide the first evidence that beta(1) integrin-dependent migratory and metastatic competence of prostate cancer cells is enhanced by Trop-2, The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1., Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation., an important role of AnxA2 in controlling dynamics of beta1 integrin at the cell surface that in turn is required for the active turnover of cell-matrix associations, cell migration, and wound closure., Findings indicate that interactions between beta1-integrin and NF-kappaB p65 were induced in nonmalignant breast epithelial cells, but not in malignant cells, indicating context-specific regulation., Suggest that fibronectin fine tunes LM332-mediated migration by boosting bronchiolar cell adhesion to substrate via integrin alpha3beta1 integrin., High integrin beta 1 expression is associated with radioresistance in astrocytoma., Both CD9/CD81-silenced cells and CD151-silenced cells showed delayed alpha3beta1-dependent cell spreading on laminin-332., Integrin beta-1(+) and p75NTR(+) cells play an important role in wound healing process, MIA protein is present in non-segmental vitiligo skin and may cause the detachment of melanocytes; its target is integrin alpha5beta1, which determines the breaking and/or weakening of connections among melanocytes and basal membrane, lipid raft integrity was required for beta1 integrin-mediated initial spreading of melanoma A375 cells on fibronectin., The data suggest that integrin beta1 is a potential biomarker for lymph node metastasis and prognosis of lung adenocarcinoma and integrin beta1 upregulation may play an important role in the pathogenesis of lung adenocarcinoma., These results showed evidence of Borrelia burgdorferi BB0172 localization in the outer membrane, the orientation of the vWFA domain to the extracellular environment, and its function as a metal ion-dependent integrin-binding protein., A specific association between alpha4beta1 and CD81, CD82 and CD151 was demonstrated and antibodies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1., Novel nonproteolytic signaling pathway initiated by single chain urokinase and mediated by domain 2 of uPAR, beta1-integrins, and VEGF receptor 2 leads to angiogenesis., changes in p38 mitogen-activated protein kinase expression together with recycling of adhesion receptors from the endosome leads to endothelial cell adhesion., These results suggest that the phosphatidylinositol 3-kinase/Akt signaling pathway plays an important role in beta1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells., 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields., Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin beta1 and beta3., beta1-Integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer., These data uncover a potential role for PKP2 upstream of beta1 integrin and RhoA in integrating cell-cell and cell-substrate contact signaling in basal keratinocytes., integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion, NG2 knockdown results in loss of beta1 integrin activation in endothelial cells, revealing a mechanism for NG2-dependent cross talk between pericytes and endothelial cells., miR-29c serves as a tumor metastasis suppressor, which suppresses lung cancer cell adhesion to ECM and metastasis by directly inhibiting integrin beta1 and MMP2 expression, Expression of the VLA-4-stimulating factor sequence may help to predict melanoma prometastatic risk., Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., expression of beta1 integrin in OECM-1 cells is involved in the development of malignant phenotypes of OSCC, Data indicate that all mesenchymal colony clusters displayed a predominant CD44+/CD24- phenotype with decreased HER-2 expression and elevated levels of a beta1-integrin isoform with a high degree of N-glycosylation., CD44v6 and integrin-beta1 mRNA and protein expression in blood may serve as biomarkers for the development and metastasis of pancreatic cancer, Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells., Autophagy regulates cell migration, a central mechanism in cell development, angiogenesis, and tumor progression, by mitigating the cell surface expression of beta1 integrins., MARVELD1 plays a role in pre-mRNA processing of integrin beta1., the alpha1 integrin subunit in Bone marrow-derived mesenchymal stem cells is important for their ability to stimulate vessel morphogenesis., ss1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion., Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury., Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1., Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin., The present study demonstrates miR-134-mediated negative regulation of beta1 integrin that influences cell adhesion to and of mesenchymal stem cells., Data indicate that levels of CXCR4 and VLA-4 did not predict acute lymphoblastic leukemia (ALL) prognosis in children, but Analysis of CXCR4 and VLA-4 levels at diagnosis in adults with ALL can provide useful information on patient prognosis., alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT., The alpha5beta1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of gastric cancer, Data indicate that in dedifferentiating chondrocytes, alpha5beta1 integrin was found to be involved in the induction of type I (COL1A1) and type III procollagen (COL3A1) expression., Data show that nucleolin is a critical lipid-raft-dependent beta1-integrin-interacting protein in A375 melanoma cell spreading and migration on fibronectin., High VLA-4 expression is associated with brain metastasis., data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells., Data indicate that macrophage-derived exosomes regulate integrin beta1-dependent migration of endothelial cells., beta1 integrin signaling in human epithelial progenitor cell, SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin beta1 signaling pathway in hepatocellular carcinoma., beta-1,4-Galactosyltransferase III suppresses beta1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer., beta1 integrin expression represents a reliable prognostic factor regarding the grading of liver metastases of colorectal cancer, Integrin alpha3beta1 mediates regulation of COX2 mRNA stability in human breast cancer cells., ITGB1 enhances epithelial-mesenchymal transition via FAK-AKT signaling pathways., ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases, In high grade malignant tumors (G1), CDH1 and ITGB1 gene expression was the highest, in G2 and G3 tumors the expression of both genes was gradually lowering, mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells, alpha5beta1 and alphav integrins are essential for cell-cell fusion and hMPV infection., the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the b1-integrin/ILK pathway., Data indicate that miR-134 suppressed the invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134., Low integrin beta 1 is associated with migration and invasion of colorectal cancer., Suggest that decreased GM1 in CFTR-silenced cells depresses beta1-integrin signaling, which contributes to the delayed wound repair observed in airway epuithelial cells., Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive., Results indicate that the signaling critical to epithelial-to-mesenchymal transition (EMT) is regulated by the beta6 integrin cytoplasmic domain., Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis., The use of inhibitors to prevent their phosphorylation or ectopic overexpression of dominant-negative IkappaBalpha perturbed ET-1-induced integrin alphaV and integrin beta1 expression., beta1 integrin participates in calreticulin (CRT)-mediated cell adhesion in J82 human bladder cancer cells., These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways., VCAM-1/VLA-4-dependent activation of NF-kappaB has a role in mediating chemoresistance in leukemia cells, the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety, Data suggest that TIMP1 (tissue inhibitor of metalloproteinase-1) acts as chemoattractant for neural stem cells (NSC); TIMP1 enhances NSC adhesion, migration, and cytoskeletal reorganization; these effects are dependent on CD29/CD63 (granulophysin)., Data indicate that alpha5beta1 integrin is recruited to lipid rafts through interactions with urokinase-type plasminogen activator receptor (uPAR)., Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation., the expression of integrin beta1 protein in cervical SCC tissues was significantly higher than that in the normal cervical tissues, and it increased with the clinical stage and the degree of malignancy., ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of colorectal cancer, a Rap1A/beta1 integrin pathway, activated downstream of G-protein-coupled receptor stimulation and RhoA, in glioblastoma cell proliferation., phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that increases metastatic potential of prostate cancer cells., Results suggest that ITGB1 regulates the growth and apoptosis of human colorectal cancer cells., circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323., Suggest that alpha5beta1-mediated cross-talk between fibronectin and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure., our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells., It plays a role in regulation of leukocyte migration to a site of inflammation., These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells., ITGB1 upregulation is involved in tumorigenesis and disease exacerbation by inflammatory cytokines as IL-6, TGF-beta1 and SDF-1, and targeting ITGB1 and the inflammatory modulator is a strategy for therapeutic intervention of ovarian carcinogenesis., abundance of LMTK3 positively correlated with that of the integrin beta1 subunit in breast cancer patient's tumors, Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543, When bound to Y. enterocolitica invasin, alpha5beta1 integrins on intestinal epithelial cells trigger interleukin (IL)-18 secretion through activation of the NLRP3 inflammasome., diabetic retinopathy is associated with ITGB1 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis), PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration., Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer, alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension., C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity., Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1., Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 protein levels in prostate cancer cells, and increased lethality., lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier, Integrin beta1 and VEGF are overexpressed and microvascular density is increased in hypopharyngeal squamous cell carcinomas., Synergy of uPAR mRNA and integrin alpha5beta1 interaction may result in abnormal signal transduction in liver cells and ultimately liver cell abnormal clonal hyperplasia and malignant transformation., This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1., indicate that no anti-tumor activity was observed in anti-alpha5beta1 integrin monoclonal antibody PF-04605412 treatment., angiopoietin-2 Gln362 mediates migration of tumor and endothelial cells through association with alpha5beta1 integrin, Data show that fluvastatin (FLV) attenuated the podocyte injury induced by puromycin aminonucleoside (PAN) and increased the production of beta1 integrin in podocytes., Data indicate that the interaction between S100A6 and integrin beta1, was confirmed by ELISA., Low NAMPT is associated with upregulation of beta1-integrin in breast tumor cells., The stimulatory cues of matrix rigidity were driven by b1 integrin mechano-sensing through FAK (pY397), and were associated with a posttranscriptionally driven rise in b1 integrin expression, This study suggested that PGE2 upregulates beta1-integrin expression and cell migration in HCC cells by activating the PKC/NF-kappaB signaling pathway, CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility., our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling, The carbon monoxide signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand., Baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways., we demonstrate that beta1 integrins have a pivotal role in breast cancer bone colonization using unique tissue-engineered humanized bone models., The cytoplasmic tail of human integrin beta-1 contributes to fibroblast cell adhesion forces., role in stretch-induced renal fibrosis through the activation of c-Src and STAT3 signaling pathways, it is not just inactivation of Fyn that promotes multicellular spheroid formation but this must be coupled with the full length beta6 integrin., integrin alpha8beta1 has a protective role in arterial remodelling and atherosclerosis, These data provide evidence for CD147 as an important determinant of radioresistance via the regulation of integrin beta1 signaling., PCTK1-KAP0-myosin X-integrin beta 1 is a functional module providing a link between ECM and the actin cytoskeleton in the cell-extracellular matrix (ECM)-dependent control of spindle orientation., Data suggest expression of B4GALT3 in placenta is up-regulated in third trimester; overexpression of B4GALT3 suppresses trophoblast migration and enhances glycosylation of ITGB1; stability of ITGB1 may regulate trophoblast invasion in late pregnancy., alpha5beta1 and alphavbeta3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the extracellular matrix., Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts., Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation., Integrin alpha5beta1 was expressed on ligamentum flavum fibroblasts., Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway., a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, an 'in solution' steady state organic fluorophore based quantitative fluorescence resonance energy transfer (FRET) assay to quantify VLA-4/VCAM-1 interaction., Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach., Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway., DPP-4 and integrin beta1 interactions regulate key endothelial cell signal transduction in both physiological and pathological conditions including endothelial mesenchymal transformation., Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis., Hyperhomocysteinemia reduces BM CD34(+)/VEGFR2(+) generation and suppresses CD34(+)/VEGFR2(+) cell mobilization and homing to the injured vessel via beta1-integrin inhibition, which contributes to impaired re-endothelialization and vascular remodeling., The driving role of the tumour microenvironment on CRC dissemination, here detected, and described, strengthens and adds new value to the concept that a5b1 integrin can be an appropriate and relevant therapeutic target for the control of CRC metastases., ITGB1 SNPs might be a prognostic biomarker for CRC., Data suggest that Entamoeba histolytica-macrophage contact triggers recruitment of alpha5beta1 integrin (ITGA5/ITGB1) and NLRP3 into intercellular junction, where ITGA5/ITGB1 undergoes activation by cysteine protease on parasite surface., the association between two genetic polymorphisms located in the VLA4 gene and the risk of multiple sclerosis, was investigated., HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion., CD105 and CD29 immunoexpression in decidua basalis, fetal membrane and placental villi showed significant negative correlations with the maternal age, This paper finds a regulatory role for beta1 integrins in the repair of radiogenic DNA damage via classical non-homologous end joining., IGFBP-2 enhances endothelial progenitor cell adhesion to HUVECs via Integrin alpha5beta1. The RGD motif in the IGFBP-2 C-domain is required for interaction with integrin alpha5beta1., Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-related biological processes, Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship, We propose that PrP modulates beta1 integrin adhesion and migration of monocytes through RhoA-induced actin remodeling mediated by cofilin, and through the regulation of ERM-mediated membrane-cytoskeleton linkage., Data show that the fold changes of very late antigen 5 VLA-5 (integrin alpha-5 beta-1) in CD14+ monocytes were higher than those observed for THP-1 cells., These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness., integrinbeta1, beta2 and beta3 are increased in patients with acute infection, which might explain the increased risk of venous thromboembolism in acute infection patients, studies suggest that the presence and spacing of the RGD and synergy sites modulate integrin alpha3beta1 binding to Fn, Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma., based on the interaction motifs in Sdc1 and Sdc4, called synstatins (SSTN210-240 and SSTN87-131) competitively displace the receptor tyrosine kinase and alpha3beta1 integrin from the syndecan with an IC50 of 100-300 nm, Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo., Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility., HPW-RX40 restores the anoikis sensitivity in the metastatic breast cancer cells by inhibiting integrin beta1 and subsequent FAK activation., blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow, CXCL12/CXCR4 activation by cancer-associated fibroblasts mediated integrin beta1 clustering at the cell surface and promoted the invasive ability of gastric cancer cells, the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion., Human uPAR activation and its association with beta1-integrin are required for PDGF-AB-induced migration., Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes., Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling., establish a paradigm according to which retrograde trafficking, and not endosomal recycling, is the key driver for beta1 integrin function in highly polarized cells, These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane., knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased, Inhibition of integrin beta1 activation on the cortex and disruption of its asymmetric distribution leads to spindle misorientation., G-CSF stimulates beta1 integrin expression and Swan 71 cell migration by activating PI3K and MAPK signaling pathways., GM2 mediats tumor cell migration by interacting with ITGB1 leading to downstream signaling and the phosphorylation of ERK MAP kinases.,
OFFICIAL_GENE_SYMBOL ITGB1,
SP_COMMENT function:Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis., online information:CD29 entry, PTM:The cysteine residues are involved in intrachain disulfide bonds., similarity:Belongs to the integrin beta chain family., similarity:Contains 1 VWFA domain., subcellular location:Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in afew intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells., subunit:Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with RAB21., tissue specificity:Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in peripheral T-cells. Isoform beta-1C is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).,
syndecan 1(SDC1) syndecan 1(SDC1) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2p24.1,
ENSEMBL_GENE_ID ENSG00000115884,
GENERIF_SUMMARY The loss of syndecan-1 expression evident in acantholytic conditions, mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma, Serum levels of soluble syndecan-1 correlated with tumor mass in patients with multiple myeloma., Soluble syndecan-1 promotes growth and dissemination of transplanted human myeloma tumors in vivo in SCID mice implanted with human bones., review of structure, function, cell and tissue distribution, regulation of expression in isoform specific manner by farnesoid X receptor, Cells adherent via syndecan-1 do not spread, but can be induced to spread by Mn(2+), suggesting that activation of a beta(1) or beta(3) integrin partner is required., TNF-alpha and IL-1beta are capable of down-regulating syndecan-1 expression, High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype, shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration, The increased stromal syndecan-1 expression, coupled with its loss from the surface of carcinoma cells, may contribute to tumor cell invasion and the development of metastases, results demonstrate that the laminin alpha3 LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1, the extracellular domain mediates an interaction that is necessary for dynamic cytoskeletal rearrangements whereas an interaction of the transmembrane domain is required for the initial spreading response, results demonstrate that cell-surface syndecan-1 is a degradative target of heparanase (HPSE-1), and syndecan-1 regulates HPSE-1 biological activity, serves as a primary human papillomavirus receptor protein in natural HPV11 infection of keratinocytes., MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface, Growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1., Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases., in hyperinflammatory lesions, ephrinB2 was predominantly expressed in macrophage-like cells and EphB4 in small venules; syntenin and syndecan-1 were up-regulated in EphB4-positive endothelial cells after stimulation with preclustered ephrinB2, syndecan-1 and glypican-1 have roles in progression of ovarian cancer, Altered matrix-dependent signaling due to increased levels of cell surface syndecan-1 may lead to epithelial cell invasion during early stages of tumorigenesis., Concomitant expression of syndecan-1 in both epithelium and stroma may be a predictor of unfavourable prognosis in breast cancer, and in contrast with previous studies, loss of epithelial syndecan-1 was associated with a more favourable prognosis, syndecan-1 is likely to be a critical regulator of many cellular behaviors that depend on activated alpha(v)beta(3) integrins, constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis lipopolysaccharide, osteoprotegerin affects monocyte mi-gration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1., syndecan-1 has a role in progression of invasive breast carcinomas through the remodeling of breast cancer tissue via interaction with other extracellular matrix components, Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC., Stromal syndecan-1 expression is an independent prognostic marker in pancreatic cancer, whereas epithelial syndecan-1 expression predicts better prognosis only in resectable disease., Loss of syndecan-1 plays a role in the growth of G-type cancers of differentiated type gastric cancers at an early stage, Low epithelial syndecan-1 expression was associated with a higher histological grade and a more advanced clinical stage of the colorectal cancer, Malignant glioma cells express all types of syndecans. NF-kappaB participates in the upregulation of the syndecan-1 expression at the transcriptional level, and increased expression of syndecan-1 could associate with thrombospondin-1., stromal fibroblast-derived Sdc1 stimulates breast carcinoma growth and angiogenesis in vivo, shed syndecan-1 or MMP7-syndecan-1 complexes may have roles in tumor progression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, The ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity., Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage immunoproliferative small intestinal disease (IPSID)., CD138 may have a role in progression of nodal diffuse large B cell lymphoma, syndecan-1 may have a role in progression of B-cell chronic lymphocytic leukemia, increase of Syndecan-1 in all tissue compartments and a redistribution from epithelium to stroma may be a characteristic feature for dense breast tissue, syndecan-1 shedding may modulate the pathogenesis of specific microbes, the endocytic path taken by Syn-1 is clathrin-independent and relies upon lipid raft function, Lacritin targets the deglycanated core protein of SDC1 and not HS chains or SDC2 or SDC4. Binding requires partial or complete removal of HS chains by endogenous HPSE. This limits lacritin activity to HPSE release sites as an HPSE 'off/on switch'., Syndecan-1 expression is uniquely influenced by changes in the phase and magnitude of the local stress field., domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility, Heparanase influences expression and shedding of syndecan-1, In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas., Decreased syndecan-1 is asociated with thyroid cancer, upregulation of syndecan-1 may be a critical element for endometrial cancers in maintaining their viability, SDC1 interaction with the LG4/5 domain in kalinin is essential for keratinocyte migration., syndecan-1 regulates keratinocyte proliferation differently during skin development and in healing wounds., Results indicate a lack of association between SDC-1 polymorphisms and risk of squamous cell carcinomas of the cervix., heparan sulfate and syndecan-1, the predominant intestinal epithelial heparan sulfate proteoglycan, are essential in maintaining intestinal epithelial barrier function., syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia, Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1)., aberrant skin expression may be involved in the development of psoriasis, n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate SDC1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect., In vitro reconstructed normal human epidermis expresses differentiation-related proteoglycans (CD44, syndecan-1, desmosealin, and 7C1)., syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma, loss of syndecan-1 epithelial expression was of strong prognostic value in breast carcinomas, Our findings thus suggest that a previously unknown link between integrin alpha2beta1 and syndecan-1 is important in regulating cell adhesion to collagen and in triggering integrin downstream signalling., CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C., Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms., Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma., Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation., syndecan-1 directly contributes to the growth and invasive ability of oral cancer cells, Plasma levels of syndecan-1 increased significantly during coronary artery bypass grafting, with or without the use of cardiopulmonary bypass., Oxidative shedding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that may contribute to pulmonary fibrosis., Proteolytic conversion of Sdc1 from a membrane-bound into a soluble molecule marks a switch from a proliferative to an invasive phenotype, with implications for breast cancer diagnostics and potential glycosaminoglycan-based therapies., Data show that syntenin-1 binds to syndecan-1 and participates in the formation of membrane protrusions, and that syntenin-1 recruitment depends on the dephosphorylation of Tyr-309 located within syndecan-1 PDZ binding domain EFYA., Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation., The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived., Results show that heparanase alters the level of nuclear syndecan-1., The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in ameloblastic carcinomas is in accordance with its higher aggressiveness as compared to the rare desmoplastic and peripheral ameloblastomas., reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma., changes in the pattern expression of syndecan-1 and -2 indicate that both molecules may be involved in the epithelial-mesenchymal transition (EMT) and tumor progression of prostate cancer., syndecan-1 is a co-receptor for APRIL and TACI at the cell surface of MMC, promoting the activation of an APRIL/TACI pathway that induces survival and proliferation in multiple myeloma cells, Results showed that epithelial syndecan-1 expression is reduced as lip carcinogenesis progresses (normal tissue>actinic cheilitis>lip squamous cell carinoma), suggesting that syndecan-1 could be a useful marker of malignant transformation in the lip., Ressutls show that cystic tumors of the pancreas express syndecan-1 and tenascin differently and suggest that low syndecan-1 expression might serve as a predictive factor for malignancy., the effects of syndecan-1 on myeloma survival, growth, and dissemination are due, at least in part, to its positive regulation of tumor-host interactions that generate an environment capable of sustaining robust tumor growth., Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Chronic inflammation and exogenous insulin usage increases the serum syndecan-1 level in type 2 diabetics., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., syndecan-1 might contribute to urothelial carcinoma cell survival and progression, higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus, ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., Sdc1 has a protective effect during experimental colitis., High CD138 serum levels are associated with B-chronic lymphocytic leukemia progression., Data substantiate the existence of a co-adhesion receptor system in tumor cells, whereby Sdc1 functions as a key regulator of cell motility and cell invasion by modulating RhoA and Rac activity., Age-associated study of detailed characterization of circulating CD138-negative and CD138-positive plasma cells sorted by flow cytometry shows a typical plasma cell cytology with no obvious morphological differences., all syndecans can interact with proteins of the actin-associated cytoskeleton--REVIEW, pathway driven by heparanase expression in myeloma cells, Decreased expression of Syndecan-1 mRNA and the increased expression of HPA-1 mRNA can promote the invasion and metastasis of colorectal cancer., Syndecan-1 shed by tumor cells exerts biologic effects distal to the primary tumor and that it participates in driving osteoclastogenesis and the resulting bone destruction., Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer., Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta1 integrin., The presence of a less mature, more resistant CD138-negative myeloma cell fraction within bone marrow microniches might contribute to high incidence of relapse of myeloma patients., Cell biological analysis established that Syndecan1 is a physiological binding partner of Tiam1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration., Expression of syndecan 1 in healthy breast tissue during menstrual cycle., Results suggest a role for syndecan-1 and cathepsins D and K in growth and invasiveness of esophageal squamous cell carcinoma., This study confirms a direct relationship between suprabasal p35 localization together with down-regulation of syndecan-1 immunoexpression and dysplastic changes of oral lichen planus and hence the possibility for malignant transformation., The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma., The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion., multiple regression analysis showed that apolipoprotein A1 was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes, A threshold of greater than six CD138+ metabolically active plasma cells is associated with poor kidney allograft function and survival., Loss of SDC-1 is associated with prostate cancer., couples the insulin-like growth factor-1 receptor to inside-out integrin activation, These results demonstrate that syndecan-1 and syndecan-2 gene silencing by RNA interference reduces HSV-1 entry, plaque formation and facilitates cell survival., SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis, High glucose can decrease the expression of core protein Sydecan-1 and Glypican-1 in cultured human renal glomerular endothelial cells., In benign samples, syndecan-1 was expressed in basal and secretory epithelial cells with basolateral membrane localisation. In prostate cancer samples syndecan 1 was expressed to granular-cytoplasmic localisation., sCD138 may be applicable as a surrogate marker of disease activity., A multiple regression analysis showed that BMI (beta = 0.783, P < 0.000) was a significant predictor of positive syndecan-1 neutrophils in subjects with type 2 diabetes., Extracellular superoxide dismutase protects cardiovascular syndecan-1 from oxidative shedding and prevents from its subsequent induction of fibroblast proliferation., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, In conclusion, CD138 expression may constitute an additional aid in the distinction between WM and SMZL., Findings show significant correlations between MMP-2, -9, and syndecan-1 and hemostatic parameters in hematologic malignancies, in contrast, the MMP inhibitors, TIMP1- and -2, were not correlated with any of the hemostatic parameters., Syndecan-1 is up-regulated in BeWo cells during differentiation and its silencing inhibits syncytialization., CD138 may contribute to the differential diagnosis of renal tumors, syndecan-1 regulates mesenchymal tumor cell adhesion and migration, and different domains have differential effects., Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype, In trauma patients, high circulating syndecan-1, a marker of endothelial glycocalyx degradation, is associated with inflammation, coagulopathy and increased mortality., These data suggest that plasma based resuscitation preserved endothelial syndecan-1 and maintained endothelial integrity., Syndecan-1 mediates hepatic VLDL turnover in humans as well as in mice and shedding might contribute to hypertriglyceridemia in patients with sepsis., a new role for syndecan-1 in HSV-1 pathogenesis, results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., We found increased vascular adhesion protein 1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock, Syndecan-1 expression was increased in tubular epithelial cells in allografts. Increased syndecan-1 in allografts correlated with low proteinuria and serum creatinine, less interstitial inflammation, less tubular atrophy and prolonged graft survival., Syndecan 1 and syndecan 2 are cellular molecules responsible for susceptibility to HTLV-1., Heparan sulfate chains of syndecan-1 regulate ectodomain shedding., Our results demonstrate that syndecan plays a negative role in death receptor-mediated cell death, CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Placental syndecan-1 expression is associated with premature birth and fetal growth., syndecan-1 is a novel target of the oncomiR miR-10b., We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM., Data indicate that immune-magnetic CD138-positive cell sorting significantly increased the percentage of abnormal cells identified in FISH analysis of multiple myeloma (MM) samples., study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization, Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness, the increased expression of syndecan-1 at gene and protein levels is correlated with advanced tumor progression and poor outcome in patients with glioma. Syndecan-1 might serve as a potential prognosis predictor of this dismal tumor., Report demonstrates that syndecan-1 enhances malignancy of a mesenchymal tumour cell line, via induction of syndecan-2 expression., observations suggest that low CD138 expression in multiple myeloma cells relates to poor prognosis, immature phenotype and low sensitivity to lenalidomide, Syndecan-1 alters the dynamic exchange of adhesion complex proteins, which in turn regulates migration speed., Novel processed form of syndecan-1 shed from SCC-9 cells plays a role in cell migration, the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain., Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases., findings demonstrate that 15-LOX-1-mediated metabolism of DHA is required for it to upregulate SDC-1 and trigger the signaling pathway that elicits apoptosis in prostate cancer cells, Data indicate that Syndecan-1 silencing had less powerful effect on the transcriptome compared to overexpression., Syndecan-1, a target of miR-10b, inhibits epithelial endometriotic cell invasiveness through down-regulation of metalloproteinase activity and interleukin-6., Sdc-1 silencing promotes increased MDA-MB-231 cell migration via a beta1-integrin-dependent mechanism., IGF1R coupled with Sdc1 is required for activation of the alphaVbeta3 integrin and for VEGFR2 signalling., The DNA methylome of CD138-positive cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain significance), early, and advanced stages of myeloma, as well as healthy controls, is characterized., SDC1 expression was not different in patients with advanced vs no/limited LBD.A significant positive correlation between gene expression & BM plasma protein levels was observed for SDC1., Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., Elevation of serum SDC1 is associated with Crohn's disease., The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating keratoacanthoma and squamous cell carcinoma, Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., SDC1 expression is associated with N stage and the status of resection margin involvement in squamous cell carcinoma (SCC) of the tonsil., High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis., Our studies demonstrates that SDC1 is the major receptor protein for HCV attachment., results indicate that angiogenesis induced by radiotherapy is associated with an MMP-9-miR-494-SDC1 regulatory loop, Through phenotype analysis, non-HAV-specific antibody-secreting cells are found to be Ki-67lowCD138highCD31highCD38high compared with HAV-specific ASCs., Comparative characteristics of the structure and function for syndecan-1 from animal organisms, Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data indicate that biochemical markers significantly associated with mesothelioma were hyaluronan, N-ERC/mesothelin and syndecan-1., Data indicate that the CD138int follicular B cells were clearly distinct from plasma cells., Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer., Chemotherapy stimulates syndecan-1 shedding, placental expression decreased in pre-eclampsia, independent of labor, gestational age, birthweight centile, SD1 mRNA levels do not differ between resected colon samples of patients with acute colonic diverticulites and ileocolonic Crohn's disease., Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells., Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways, It is concluded that increased SNAIL levels in advanced PC are associated with low expression of syndecan 1, Urinary levels and cellular localization of syndecan-1 are associated with differentiation status of patients with bladder cancer., Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells., Presence of SDC1 in tumor stroma is an independent risk factor for patient survival in bladder cancer, this study revealed a link between miRNA-143 and Syn-1 in the pathogenesis of melanoma., Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection., Expression decreased with the decreasing grades of dysplasia. Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., HO-1, S100A4, and SYND1 expressions have prognostic value in primary non-muscle-invasive bladder cancer (NMIBC)., Syndecan 1 mRNA expression did not vary between chronic diverticulitis and Crohn's disease., In DCIS of different nuclear grades, tissue localization of syndecan-1 is significantly divergent, suggesting a specific effect on biology and progression of DCIS., Increased syndecan-1 expression levels may indicate a high degree of differentiation, an early clinical stage and a favorable prognosis of malignant gastric cardiac adenocarcinoma., Elevated levels of soluble CD138/Sdc-1 in older bladder cancer patients and those with muscular invasion sheds some light on the mechanisms of the disease invasion., Syndecan-1 is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts., syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma., syndecan-1(+) cell syncytia and excess GAG production recapitulate elements of the invertebrate encapsulation reaction, itself dependent on insect transglutaminase and glutaminated early response proteins, Sdc1 is required for HER2-mediated activation of the alpha6beta4 integrin in wound healing assays or tumor cell survival., PKC-mediated syndecan-1 downregulation causes loss of cell invasiveness in melanoma cells under anchorage independency, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., syndecan-1 may have a role as a biological and prognostic marker in patients with triple-positive breast carcinomas, The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes, High Syndecan-1 expression is associated with chemotherapy resistance in colorectal cancer., High expression of SDC1 is associated with dedifferentiated liposarcoma tumorigenesis., Our study indicates that SDC1 expressed by the bone marrow microenvironment is involved in angiogenesis in MM., A significant association between SDC1 and breast cancer was identified., this work has broad implications beyond myeloma because shed syndecan-1 is present in high levels in many tumor types as well as in other disease states., Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer, Serum SDC-1 levels are increased in systemic lupus erythematosus patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN., Syndecan-1 expression is associated with tumor size and EGFR expression in colorectal carcinoma, This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation., our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans, syndecan-1 has a role in glycocalyx shedding and is increased in patients with end-stage liver disease; ischemia-reperfusion injury during OLT further exacerbates glycocalyx shedding, Sdc-1 may act as a modulator of ESC apoptosis and probably invasion depth as a crucial factor for successful pregnancy., The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality., Elevated plasma syndecan-1 levels in renal transplantation patients might be interpreted as repair/survival factor related to loss of tubular and endothelial function in transplanted kidneys., Despite presence of the HPV-receptor syndecan-1 in tongue squamous cell carcinoma (TSCC), HPV prefers the tonsillar environment., miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1., SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma., HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts., stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma, miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation., The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients., Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis., The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment., The detection of syndecan-1 in endometrial cancer of different clinical and histological stages could be of prognostic value in clinical diagnosis.,
SP_COMMENT function:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix., similarity:Belongs to the syndecan proteoglycan family., subunit:Interacts with CDCP1.,
syndecan 4(SDC4) syndecan 4(SDC4) Related Genes Homo sapiens
CHROMOSOME 20,
CYTOBAND 20q12,
ENSEMBL_GENE_ID ENSG00000124145,
GENERIF_SUMMARY Studies suggest that antithrombin regulates neutrophil migration via effects of its heparin-binding site on cell surface syndecan-4., Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes, Clustering induces redistribution of syndecan-4 core protein into raft membrane domains, Syndecan-4 core protein mediates the effects of fibroblast growth factor (FGF)2 on cell function. PKCalpha activation and PDZ-mediated formation of a serine/threonine phosphatase-containing complex by syndecan-4 are downstream events of FGF2 signaling., SDC4 regulates inositol phospholipid binding and signaling, the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner, Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA, endotoxin-induced adhesion of leukocytes to endothelium can be reversed by ligation of syndecan-4 with antithrombin's heparin-binding site, syndecan-4/CXCR4 complex is likely a functional unit involved in SDF-1 binding, human trabecular meshwork cells express only syndecan-1, and not syndecan-4, at the cell surface, and focal adhesion and stress fiber formation occur independent of syndecan-4, Syndecan-4 has a critical role in thrombin-induced migration and proliferation in human vascular smooth muscle cells, CXCL12 directly binds to syndecan-4 in a glycosaminoglycan-dependent manner, may play important roles in the regulation of inflammatory effects of platelets, Plasmin and thrombin accelerate shedding of syndecan-4 ectodomain, which generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds, the transmembrane domains are sufficient for inducing dimerization and transmembrane domain-induced oligomerization is crucial for syndecan-2 and syndecan-4 functions, The H. pylori- and TLR-induced increase in syndecan-4 mRNA was blocked by the proteosome inhibitor MG-132 suggesting a role for nuclear factor kappaB (NF-kappaB) in the regulation of syndecan-4 gene expression, Syndecan-1 and syndecan-4 may have roles in progression of breast carcinoma, Stress-induced effects on smooth muscle cell syndecan-4 expression and shedding may represent an additional component of proinflammatory, growth-stimulating pathways activated in response to changes in the mechanical microenvironment of the vascular wall., The expression of syndecan-4 protein was significantly enhanced by TNF-alpha in HUVECs., An alternate pathway mediated by the extracellular domains of syndecans-2 and -4 is characterized that is independent of both heparan sulphate and syndecan signaling., These results identify syndecan-4 as a novel receptor for the N-terminus of TSP-1 and suggest that TSP-1 N-terminal pro-angiogenic activity is linked to its capacity of interfering with syndecan-4 functions in the course of cell adhesion., analysis of how a peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4, syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context, syndecan-4 is a critical intrinsic regulator of inflammatory reactions via its effects on OPN function, This study provides evidence for the up-regulation of syndecan-2 and -4 in human primary CD4 T cells during in vitro activation and suggest an inhibitory role for these syndecans in CD4 T cells., TG-FN binding to syndecan-4 activates PKCalpha leading to its association with beta(1) integrin, reinforcement of actin-stress fiber organization, and MAPK pathway activation, None of the SDC4 polymorphisms showed a difference in their allelic distribution between leg ulcer patients and controls. SDC4 may play a role in wound healing, but expression abnormalities in uninvolved dermis may contribute to venous ulcer development., ADAMTS1, involved in angiogenesis and inflammatory processes, cleaves the ectodomain of syndecan-4. This cleavage results in altered distribution of cytoskeleton components, functional loss of adhesion, and gain of migratory capacities., SD-4 is the T-cell ligand of DC-HIL., The present study shows that highly pathogenic H. pylori strains induce syndecan-4 expression, both in human gastric mucosa and in gastric cell lines, in a cag pathogenicity island-dependent manner., Syndecan-4 may be a sensor of tension exerted on the matrix [review], Study indicates that SDC-1 and -4 may be required for HepG2, Hep3B and Huh7 human hepatoma cell migration, invasion or spreading induced by the chemokine., syndecan-4 is specifically induced in type X collagen-producing chondrocytes in osteoarthritis, The down-regulation of syndecan-4, a heparan sulfate proteoglycan, decreased SDF-1/CXCL12-mediated HeLa cell invasion., syndecan 1 and 4 correlate to increased metastatic potential in melanoma patients and are an important component of the Wnt5A autocrine signaling loop, Study identified an overrepresentation of focal amplifications of known (FGFR3, CCND1, MYC, MDM2) and novel candidate genes (MYBL2, YWHAB and SDC4) in stage Ta bladder carcinoma., Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., ADAM17 may therefore be an important regulator of syndecan functions on inflamed lung epithelium., SDC4 promotes cytokinesis in a phosphorylation-dependent manner in MCF-7 breast adenocarcinoma cells. The serine179-phosphorylation and the ectodomain shedding of SDC4 changed periodically in a cell cycle-dependent way., Expression of syndecan 4 in healthy human breast tissue during menstrual cycle., In dendritic cells, lysophosphatidylcholine-induced phosphorylation of SDC4 by PKCdelta results in a functional inactivation of SDC4 and decreases adhesion and motility., Data found that Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4., RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling., syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides., SD-4 bearing distinct heparan sulfate moieties plays a pathogenic role in Sezary syndrome and may be targeted for treatment., Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion, There was a statistical relationship between syndecan-1 presence in high-grade tumors and absence of syndecan-4, whereas syndecan-4 presence in cases positive for estrogen and progesterone receptor associated with syndecan-1 absence, HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production., in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5., Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway, By accruing more syndecan-4 on their surface and also shedding it during Th1 cytokine-driven inflammation, asthmatic airway smooth muscle cells may regulate inflammation and remodeling locally and alter the responsiveness of the airways in asthma., the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4., Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour., studies identify S4 as a regulator of MAPK signaling and address the question of how distinct classes of FGFRs individually contribute to signal transduction in endothelial cells, Syndecan-4 expression and shedding were increased in failing human myocardium., EGFR are the key mediators of SDC-4 expression in MCF-7 cells., TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis, PGE2-induced activation of angiogenesis is mediated via syndecan-4-dependent activation of PKCalpha., NF-kappaB p65 could be a key mediator of syndecan-4 upregulation by TNF-alpha through two binding sites in the SDC4 promoter, but other NF-kappaB-p65 independent pathways might also be involved through transcriptional elongation., syndecan-4 is differentially expressed in seminomas and nonseminomatous germ cell tumours and might be a useful marker., The more upgraded the NYHA grading, the higher level of serum syndecan-4 protein., in healthy discs, SDC4, through its heparan sulfate side chains, contributes to maintenance of the hypoxic tissue niche by controlling baseline expression of Sox9., The cytoplasmic V domain of syndecan-4 made a significant contribution to the cellular uptake of octaarginine, whereas the cytoplasmic C1 and C2 domains were not involved in the process., High glucose modifies TRPC6 channels and ROS production via SDC-4 in human podocytes., Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions., syndecan 4 is the predominant heparan sulfate proteoglycan in the glomerular endothelial cells glycocalyx, Sdc4 is necessary for activation of the integrin during chemokinesis induced by EGF., Dynamic catch of a Thy-1-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium., No association was found with SDC4 and breast cancer., Data indicate that depletion of syndecan 4 (S4) in umbilical vein endothelial cells (HUVECs) using shRNA inhibited flow-induced alignment in vitro, which was rescued by re-expression of S4., Syndecan-4 polymorphisms were associated with essential hypertension, body mass index, and coronary artery disease prevalence in the Tampere adult population cardiovascular risk study., define a role for TG2 activity at the surface of human macrophages in multiple stages of AC clearance and we propose that TG2, in association with heparan sulphates may exert its effect on AC clearance via a mechanism involving the crosslinking of CD44, Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility., results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity., Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4,
SP_COMMENT function:Cell surface proteoglycan that bears heparan sulfate., function:Cell surface proteoglycan., similarity:Belongs to the syndecan proteoglycan family., subunit:Homodimer. Interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS (By similarity). Interacts with SDCBP., tissue specificity:Expressed in epithelial and fibroblastic cells.,
thrombospondin 1(THBS1) thrombospondin 1(THBS1) Related Genes Homo sapiens
CHROMOSOME 15,
CYTOBAND 15q15,
ENSEMBL_GENE_ID ENSG00000137801,
GENERIF_SUMMARY Increased expression is associated with breast tumor metastasis, Immobilized TSP-1, as well as its 70-kDa proteolytic fragment containing the type 1 repeats, enhances IL-6 release from monocytic U937 cells stimulated with phorbol myristate acetate and LPS, whereas it inhibits IL-10 release., Stromally derived TSP-1 upregulates the production of MMP-9 and regulates matrix remodeling of tumor invasion in pancreatic adenocarcinoma, T lymphocytes express thrombospondin-1 (TSP-1). Endogenous TSP-1 is part of an adhesion-dependent mechanism controlling cytoplasmic spreading and migration in T lymphocytes., Thrombin activation leads to the rapid and specific association of a large amount of secreted alpha-granular TSP-1 with the actin cytoskeleton., Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior, level spontaneously secreted by patient CLL B-cells quantified; consistently secreted in all patient samples., mediates adhesion of osteosarcoma to the core region of thrombospondin 1 (alpha 4 beta 1 integrin), structural characterization, Anti-adhesive activity mediated by the N-terminal domain of cell surface calreticulin, Interaction of the TSP1 module of complement component C8 beta subunit with the membrane attack/perforin domain determines the binding specificity of C8 beta toward C8 alpha., All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas) expressed both TSP1 and TSP2 mRNAs. Correlated closely with the expression of ACTH receptor., a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine, capped by disulfide bonds; the front face contains a right-handed spiral, positively charged groove that might be the "recognition" face., thrombospondin-1 plays a role in the up-regulation of MMP-9 expression in gastric cancer., The anti-angiogenic type 1 repeat domains of TSP1 have been biophysically characterized and the disulfide bond connectivity of the peptides determined., Thrombospondin-1 is differently expressed in subcutaneous and visceral fat of obese subjects. The difference in expression between the depots was greater in women than in men., TSP1 is expressed in tumor stroma in colorectal cancer, inhibits tumor angiogenesis and suppresses tumor growth by activating TGF beta-1., Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on this protein., Mutation of p53 gene endows gliomas with an angiogenic phenotype by reducing thrombospondin-1 production as well as enhancing the angiogenesis inducers in the early phase of malignant progression., the migration of retinal pigment cells in epiretinal membranes is modulated by TSP1 and SPARC and thus that these two proteins ultimately may represent therapeutic targets in the management of the membranes., TSP1 is the critical regulator of angiogenesis driven by ras proteins in a genetically defined tumor model., TSP-1-induced inhibition of megakaryocytopoiesis is probably mediated in part by the binding of TSP-1 to CD36 expressed on the megakaryocytic progenitors, interactions among the three structural motifs of the C-terminal region of this protein, Our results suggest that transcriptional inactivation of TSP1 by aberrant DNA methylation of the promoter region may participate partly in stomach carcinogenesis through TSP1 down-regulation., thrombospondin-1 (4N1-1) stimulates platelet aggregation by a novel mechanism involving both an activation-independent agglutination and an activation-dependent, glycoprotein (GP) IIb/IIIa-mediated aggregation which involves GPVI signaling, Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib., Interaction of thrombospondin-1 with its ligand CD47 contributes to the perpetuation of inflammation in rheumatoid synovitis., thrombospondin-1 and thrombospondin-2 have N-terminal regions for binding to alpha6beta1 integrin, TSP1 expression is significantly higher in malignant epithelial sources over normal and benign epithelial sources, but no difference in expression levels is evident between primary tumors with or without metastases., TSP-1 acts as a scavenger for matrix-associated angiogenic factors, affecting their location, bioavailability, and function., thrombospondin-1 has a role in motility and proteolytic activity of oral squamous cell carcinoma cells, Hepatocyte growth factor mediates angiogenesis in cultured cancer cells by regulating the expression of VEGF and this protein., Expression of TSP-1 along with other genes suppresses neuronblastoma tumor growth., DC-derived TSP serves as a previously unappreciated negative regulator contributing to arrest of cytokine production, further supporting its fundamental role in vivo in the active resolution of inflammation and maintenance of steady state., ANG II-induced activation of latent TGF-beta1 in human mesangial cells operates via TSP-1., TSP-1 might mediate AGE-induced distal renal tubule hypertrophy. There are several putative transcription factor binding sites in the TSP-1 promoter, including those for AP-1, CREB, NF-kappaB, SRF, and HSF., results indicate that TSP-1 binding to low density lipoprotein-related protein does not require prior or concomitant interaction with cell surface heparan sulfate proteoglycans but suggest subsequent endocytosis requires high-affinity heparin-binding, functional and structural differences between the Ser-700 and Asn-700 thrombospondin-1 variants, crystal structure of a cell-binding TSP-1 fragment, spanning three T3 repeats and the C-terminal globular domain, reveals a compact assembly, Review, This study showed for the first time that in human umbilical vein endothelial cells (HUVECs), 17beta-E2 transiently down-regulates the expression and secretion of a potent negative regulator of angiogenesis, thrombospondin-1 (TSP-1)., downregulation of TSP-1 up to 18h following ultraviolet b light exposure, No association of the TSP-1 polymorphism with myocardial infarction was found in an ethnic Chinese Han population in Beijing., Increased expression of TSP1 is associated with an aggressive angiogenic phenotype in melanoma., THBS 1 and VEGF are proangiogenic factors that stimulate angiogenesis in hepatocellular carcinoma, beta(1) integrins mediate cell adhesion to the type 1 and type 2 repeats, Data show that the WSXW motif binds the VLAL sequence on both latency-associated peptide and mature TGF-beta, and these interactions are critical for thrombospondin-1-mediated activation of the TGF-beta latent complex., results indicate that transforming growth factor TGFbeta1 treatment may regulate angiogenesis in pituitary cells by initially increasing levels of pro-angiogenic growth factor VEGF-A and then stimulating anti-angiogenic thrombospondin -1 and 2 levels, TSP-1 from activated platelet releasate acts with vitamin D-binding protein to enhance complement 5a-mediated chemotaxis., Ser-700 polymorphism alters a rapidly filled, high affinity Ca2+ -binding site in the first Ca2+ -binding motif in thrombospondin-1 associated with familial premature coronary artery disease, the circulating TSP-1/vascular endothelial growth factor balance is diminished in cancer patients, Able to inhibit or stimulate tumor progression and angiogenesis, as well as affect wound healing, platelet aggregation, and arterial remodeling. Review., TSP-1 located at the border between tumor and stroma as observed in primary prostate tumors may act as a barrier of tumor growth, Endogenous calreticulin binding to the N-terminal domain of endogenous thrombospondin-1 (TSP-1) elicits a motogenic signal to the T cells through the C-terminal domain of TSP-1 and its cell surface receptor integrin-associated protein (CD47)., In human androgen-dependent localized prostate carcinomas, TSP1 expression was inversely correlated with blood vessel density., Thrombospondin 1, which plays a key role in initial immune defense, was found to be the most markedly up-regulated gene in blood after exposure to stents in vitro., thrombin formed at sites of vascular injury increases THBS1 expression into the extracellular matrix via activation of a PAR-1, G(i/o), G(q), EBOX/EGRF-signaling cascade, TSP-1 may contribute to the regulation of neovascularization in the endometrium and gestational tissues., Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium., Constitutive overexpression of TSP-1 may play an important role in autocrine TGF-beta signaling and accumulation of extracellular matrix in scleroderma fibroblasts., thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor, TSP-1 could enhance conversion of latent TGF-beta1 into active TGF-beta1 in a cell-free system. Ox-LDL interacts with TSP-1 and suppresses subsequent TSP-1-dependent TGF-beta activation., an extracellular matrix glycoprotein implicated in the regulation of angiogenesis and tumour development, Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin-like growth factor binding protein 3, Increased TSP1 levels in blood is asociated with non-small cell lung cancer, Results suggest a physiological function of thrombospondin-1 binding to TSG-6 in regulation of hyaluronan metabolism at sites of inflammation., specific amino acids of the C-terminal cytoplasmic tail of CD36 are crucial for the in vitro angiostatic activity of TSP-1, Transcripts for THBS1, an activator of TGF-Beta, increased during acute lung injury in mice, positive- and negative-feedback loops exist between NO and TSP1; limiting TSP1 expression by positive feedback through the ERK mitogen-activated protein kinase pathway may facilitate switching to a proangiogenic state at low doses of NO, Here we reported that the genomic lotus of TSP1 also transcribes a natural antisense transcript (NAT) with an overlapping and reverse complement region against TSP1., A387P in thrombospondin-4 and N700S in thrombospondin-1 polymorphisms perturb calcium binding sites, results demonstrate a potent antagonism between TSP1 and proangiogenic signaling downstream of NO, Thrombospondin 1 is a negatively prognostic factor for survival in resected colorectal liver metastases., Increased glomerular expression of thrombospondin-1 (THBS1), transforming growth factor beta 1 (TGFB1), and connective tissue growth factor (CTGF), occurs from the earliest stage of diabetic nephropathy., Data show that transcriptional control is not involved in the induction of thrombospondin-1 by heat shock., TSP-1 expression was associated with a significantly lower level of microvessel density., acute UV exposure downregulates TSP1 expression via PI3K-Akt activation in human keratinocytes, Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, TSP-1 mRNA is a possible marker for contamination of thyroid-derived fibroblasts., IL-18 plays a key role in thrombospondin-1 expression involving JNK., Correlation of stromal TSP-1 expression with extracellular matrix components fibronectin and tenascin indicate its possible implication in tumour stroma remodeling., Edogenous TSP-1 connects separate cell-surface receptors functionally and regulates T-cell adhesion., apoptotic cell TSP-1, and notably its heparin-binding domain, creates a signalosome in iDCs to improve engulfment and to tolerate engulfed material prior to the interaction with apoptotic cells, Anti-inflammatory extracellular matrix protein thrombospondin-1 promotes the generation of human peripheral regulatory T cells through the ligation of its receptor, CD47., These findings suggest that induction of apoptosis by camptothecin or doxorubicin in FTC-133 cells is greatly dependent by a down-regulation of TSP-1 expression and shed new light on a possible role for TSP-1 in drug resistance., cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1 [review], By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP-1 in spontaneously regressing keratoacanthoma and squamous cell carcinoma, the changes in the expression of these proteins to specific stages of skin carcinogenesis, is defined., thrombospondin-1 signaling has a role in tumor angiogenesis [review], In this review the authors provide mechanistic insight into the signaling pathways used by thrombospondin-1 and CD47 at the cellular and molecular level to prevent nitric oxide signaling through cyclic GMP, thereby exacerbating tissue ischemia., The prognosis was worst in patients with cancers that were VEGFA-positive and THBS1 methylation-positive., TSP-1 expression in choroidal neovascular membranes was upregulated and associated with the retinal pigment epithelium monolayer in early age-related macular degeneration., alpha9beta1 integrin expressed on microvascular endothelial cells interacts with thrombospondin-1, and this interaction is involved in modulation of angiogenesis., identified combined decrease of NFkappaB and increased TSP1 as molecular events underlying the AR anti-tumor activity in vivo, Data show that thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan., Upregulation of thrombospondin-1(TSP-1)in sporadic inclusion body myositis., Thrombospondin 1 induces a unique antiangiogenic response in certain types of vascular cells, blocks the cell cycle, and suppresses angiogenesis in vivo., two mAbs that recognize epitopes that are optimally present when three elements of signature domains of TSP-1 and TSP-2, the EGF-like modules, wire, and the lectin-like module, are in the same protein., EWS/FLI1 has a role in regulating tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins TSP1 and TSP2, TSP-1 expression was detected in 17.5% of the cases with NHL, and is associated with aggressive histology and shorter overall survival., Patients with a truly negative sentinel node (pN0[i-][sn]) frequently have higher expression of TSP-1 that may have inhibited metastatic progression., These results identify syndecan-4 as a novel receptor for the N-terminus of TSP-1 and suggest that TSP-1 N-terminal pro-angiogenic activity is linked to its capacity of interfering with syndecan-4 functions in the course of cell adhesion., Studied four angiogenic gene SNPs (VEGF-1154G/A;VEGF-634G/C;MMP9-1562C/T and TSP1-8831A/G)in combination to the risk of prostate cancer. Results suggest the gene-gene polymorphisms' interaction increased risk of prostate cancer onset & aggressiveness., Study demonstrates that the fibroblast growth factor-2 binding site of thrombospondin-1 is located in the type III repeats., Sudy indicates that TRPC4 loss in renal cell carcinoma (RCC) leads to impaired Ca(2+) intake, misfolding, retrograde transport and diminished secretion of antiangiogenic TSP1, thus enabling angiogenic switch during RCC progression., TSP1 is an important link between adipocytes and macrophage-driven adipose tissue inflammation., Thrombospondin-1 was consistently underexpressed in both the edge and center of uterine fibroids., The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications, The meta-analysis included 6388 (TSP-1), 4930 (TSP-2), and 6978 (TSP-4) cases; none of the polymorphisms was found to be linked with the risk of myocardial infarction., TSP-1 A2210G variant has a dramatically lower prevalence in the Chinese Han population and fail to associate with myocardial infarction., The data document the importance of TSP-1 in promoting MMP-2-mediated cancer cell invasion., indicate connectivity between calcium binding sites in the C-terminal signature domain and the N-modules of thrombospondin-1 that regulates ligand binding and functional activities of the N-modules, trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation., Results suggest focal adhesion kinase is involved in thrombospondin-1-induced vascular smooth muscle cell migration., TSP-1 promotes human follicular thyroid carcinoma cell invasion mainly through up-regulation of the urokinase-dependent activity., the epigenetic inactivation of TSP-1 and RASSF1-A genes is associated with pathological variables and seems to be of prognostic significance in penile cancer., These results suggest that the hypoxia induces the migration of coronary artery smooth muscle cells, and that the migration is elicited by TSP-1 of which induction is fully dependent on the stabilization of HIF-1alpha, in autocrine regulation., a novel role of TSP-1 to inhibit tumor-stroma reaction that could be attributed to the blockage of activated fibroblasts from invading cancer cells., The aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer., although Thrombospondins harboring the Ser allele binds a full complement of calcium ions, repeat 1C is altered, leading to destabilization of surrounding structures, The constitutively active form of AhR induced activation of the thrombospondin-1 gene promoter., The effects of TSP-1 on endothelial cell migration are mediated by TGF-beta1, whereas the effects on fibroblast and tumour cell migration are TGF-beta1-independent., HuR plays an important role in translation of the TSP1 mRNA., a novel role for TSP1 signaling through the calreticulin/LRP1 co-complex in tissue remodeling and fibrotic responses through stimulation of anoikis resistance., recent results dealing with regulation of TSP-1 expression by epidermal growth factor & hepatocyte growth factor; results show TSP-1 can have opposite effects on cell invasion depending upon type of differentiated thyroid carcinoma studied [review], This study demonstrates increased plasma levels of TSP1, which correlated with increased levels of proinflammatory cytokines in plasma of rheumatoid arthritis patients., TSP-1's C-terminal domain opens to interact with the CD-47 receptor, The positive correlation of glomerular p-smad2/3 positivity with proteinuria further supports the importance of the TSP-1/TGF-beta system as a relevant mechanism for progression of type-2 diabetic nephropathy, Data show that calumenin in the presence of calcium binds specifically to thrombospondin-1, but closely-related reticulocalbin does not form a similar complex., Decreased TSP-I expression may explain reduced synaptogenesis and altered hippocampal ultrastucture, both of which may contribute to the pathogenesis of diabetic dementia., This observation highlights the role of TSP-1 in hemorrhagic fever with renal syndrome which might have further prognostic and therapeutic implications., TSP1 may play an important role in antitumor immunity by enhancing recruitment and activation of M1 tumor associated macrophages, which provides an additional selective pressure for loss of TSP1 and TSP2 expression during tumor progression, Positive VEGF expression and negative TSP1 expression were positively correlated with postoperative recurrence of epithelial ovarian cancer., a profound increase in TSP-1 levels and a corresponding increase in PAI-1 activity by insulin in vivo, The present review illustrates the dynamic processes involved in the functional cross-talk between von Willebrand factor and thrombospondin-1, both proteins having properties that are highly controlled by the shear stress in their environment., In this review, the CD47/thrombospondin-1/signal regulatory protein (SIRP)-alpha) inhibitory axis is proposed as an important sensor to maintain homeostasis and regulate innate and adaptive immune responses., TSP-1 on decidual macrophages could influence IL-10 expression as Th2 cytokines. The abnormal expression of TSP-1 could make some women undergo pregnancy loss., These findings suggest a positive role of RRM2 in tumor angiogenesis and growth through regulation of the expression of TSP-1 and VEGF., Three proteins were significantly elevated in PTB cases, Expression of thrombospondin-1 in the dnTbetaRII tumor or treatment with sorafenib or anti-VEGF antibody reduced tumor growth, whereas knockdown of thrombospondin-1 expression resulted in more accelerated growth of OCUM-2MLN tumors than of GFP tumors, The lack of correlation between microvessel density and TSP-1 expression in adenocarcinoma suggests that the mechanism of tumour inhibition by TSP-1 varies according to histological type., did not find any correlation between TSP-1 staining and angiogenesis, platelet counts, platelet activity, and the histological prognostic parameters, Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1., In brains from aged individuals and patients with vascular dementia, thrombospondin 1 was localized to neurons, but was most prominently localized to corpora amylacea., Multivariate analysis showed that high TXR1/low TSP1 expression was an independent prognostic factor for decreased median time to tumor progression (TTP) and median overall survival (mOS)., ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation, [review] The TSP1/transforming growth factor beta/ connective tissue growth factor axis may contribute in the pro-inflammatory and pro-atherogenic state in patients affected with rheumatoid arthritis., TSP-1 is a transcriptional repression target of PRMT6, analysis of interactions among the epidermal growth factor-like modules of thrombospondin-1, Since tumor cell-derived TSP-1 has the potential to promote angiogenesis in the tumor microenvironment, it could be a potential target for breast cancer therapy., Prosaposin functions in a paracrine and endocrine fashion by stimulating the expression of thrombospondin-1 (Tsp-1) in fibroblasts present in both primary tumors and distant organs, doing so in a p53-dependent manner., Upregulation of thrombospondin-1 and angiogenesis is associated with pancreatic cancer metastasis., Disruption of CD47-TSP-1 interactions or preventing the recruitment of DCs to tumors may provide novel approaches to therapy of myeloma bone disease and osteoporosis., CD26 is an endogenous inhibitor of T cell motility through inhibition of TSP-1 expression and chemokines stimulate cell polarity and migration through abrogation of the CD26-dependent inhibition, THBS1, Cyr61 and CTGF were all over-expressed in esophageal squamous cell carcinoma., analysis of stalk module of thrombospondin-1 interactions, These results implicate Id1 and TSP1 as downstream mediators of Epac/Rap1, inhibitory regulators of the angiogenic process, Patients with end-stage heart failure show decreased TSP-1 mRNA levels, which agrees with published results showing lower circulating TSP-1., we were able to show that heparin binding domain (HBD), the N-terminal portion of TSP-1, was cleaved and secreted simultaneously in a caspase- and serine protease- dependent manner, In endometrial stromal cells from endometriosis patients TSP-1 levels were decreased by estradiol and increased by progesterone., TSP-1 is involved in influencing the critical balance between matrix metalloproteinases and their inhibitors, maintaining the controlled degradation of the extracellular matrix needed to support metastasis., Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma., The upregulation of both sst2 and TSP-1 tumor suppressors may function as an early negative feedback to restrain pancreatic carcinogenesis., Data suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter., Positive TSP-1 expression is associated with low malignancy/good prognosis. Protein expression status may help assess tumor malignancy and patient prognosis., Promoter hypermethylation of TSP1 may play an important role in the development of gastric cardia adenocarcinoma and reflect the biological behaviours of GCA., HGF is a potential downregulator of TSP-1, through MAPK signaling pathways, leading to the induction of MMP-9 expression and subsequent invasion of SKOV-3ovarian cancer cells., Data suggest that ions from stainless stell stent corrosion contribute to in-stent restenosis through stimulation of TSP1-dependent TGF-beta activation., thrombospondin-1 mimics are fibroblast growth factor-2 inhibitors, results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments., the platelet content of VEGF-A in cancer patients was significantly increased compared to healthy controls, while thrombospondin-1, CXCL12 and CXCL4 were significantly decreased, stromal TSP1 expression is a prognostic indicator and a new marker of invasiveness in IPMN., high p21waf-1 or tsp-1 mean expression level comprised small-sized, low-grade, node-negative ductal breast carcinomas, epigenetic silencing of TSP1 gene by promoter hypermethylation may play an important role in gastric cardia adenocarcinoma, thymidine phosphorylase has a role in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells, Circulating thrombospondin 1 level did not correlate with clinical benefit in patients receiving cyclophosphamide-based metronomic therapy., critical role in prostate epithelial and stromal growth regulation through angiogenic inhibition and activation of latent TGF-beta, In muscle biopsies from dysferlinopathy patients, TSP-1 expression was increased in muscle fibers but not in biopsies of patientswith other myopathies with inflammation; TSP-1 was seen in some macrophages in all samples analyzed., tasquinimod-induced up-regulation of TSP1 is part of a mechanism involving down-regulation of HIF1alpha and VEGF, which in turn leads to reduced angiogenesis, Thrombospondin-1 is a unique marker to identify in vitro platelet activation when monitoring in vivo processes, Thrombospondin-1 attenuates type I procollagen downregulation in human dermal fibroblasts., Knockdown of B-Raf(V600E) resulted in TSP-1 down-regulation and a reduction of adhesion and migration/invasion of human thyroid cancer cells., ADAMTS1 is an important regulatory factor of angiogenesis and tumor growth in prostate tumors, where modified ADAMTS1 expression resulted in markedly changed blood vessel morphology, possibly related to altered thrombospondin 1 levels., TSP-1 in primary myelofibrosis is likely to be a mediator within a pro-fibrotic environment which discriminates from essential thrombocythemia cases., Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms., ADAMTS13 interacted with the rVWF A1, A2, A3 domains and full-length VWF, while TSP1 also bound to three A domains, especially to A2 and A3 domains., Findings indicate thst Myc-regulatory networks target Tsp-1 via multiple mechanisms in medulloblastoma transformation., Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47, Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression., TSP-1 expression had positive association with VEGF expression, microvessel density (MVD) and TGF-beta expression in gastric cancer., Engineered mutations of TSP1 can directly cause changes in electrostatic energy, van der Waals energy, polar solvation energy, and entropy for interactions of TSP1 with CRT and, thereby, contribute to loss of TSP1 and CRT binding., TSP-1 is a potential biomarker of peripheral arterial disease and endothelial cell progenitor-induced angiogenesis, suggesting that TSP-1 modulation might improve local tissue ischemia in this setting., thrombospondin-1 deficits have a role in astrocyte-mediated spine and synaptic pathology in Down's syndrome, Low TXR1 mRNA levels were associated with higher response rate (RR), longer median progression-free survival (PFS) and median overall survival (mOS), whereas high TSP1 expression was correlated with higher RR, longer PFS and mOS, AU rich elements in the 3'UTR control TSP-1 mRNA stability and that the RNA binding protein AUF1 participates in this control., Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis., glucocorticoids interact directly with glucocorticoid receptors on vascular endothelial cells to inhibit tube-like structure formation in a process involving thrombospondin 1, Using siRNA approach the demonstrated that hepatitis C virus-induced furin and thrombospondin-1 (TSP-1) are involved in the proteolytic activation of TGF-beta1., A novel role for thrombospondin-1 provides a context for its use in the pathobiology and management of cerebral arteriovenous malformation., The translation of this three-dimensional information into a pharmacophore model allowed screening a small molecule databases, identifying three FGF-2-binding, antiangiogenic small molecules, mimetic of TSP-1., inhibition of T cell receptor signaling by thrombospondin-1 is mediated by CD47 and requires its modification at Ser(64)., new role for TSP-1 and CD36 in the activation of the VEGFR-2 signaling pathway that requires Syk, The association of thrombospondin-1 and FRP1 is primarily mediated by the amino-terminal N-module of thrombospondin-1 and the netrin domain of FRP1., Four peptide sequences related to thrombospondin-1B were characterised by HPLC capacity factors, UV, fluorescence, and CD spectra (either in buffer solution or in the presence of lipid vesicles), surface activity, and aggregation., TSP-mediated interaction may initiate cell adhesion by capturing the fast flowing infected red blood cells whereas CD36 functions as the 'holder' for providing stable binding., serum changes of three glycoproteins, galectin-3 binding protein, insulin-like growth factor binding protein 3, and thrombospondin 1, was associated with the development of hepatocellular carcinoma, Connective tissue growth factor and TSP-1 expression are elevated in human heart failure., found no evidence to support a relationship between genetic variations in thrombospondin genes and the occurrence of CHD; genetic variations in THBS1 and THBS2 are weakly involved in the regulation of VWF, Histone hypoacetylation and DNA hypermethylation in the 5' region of THBS1 may explain the inability of lunasin to upregulate this gene in RWPE-2 cells., These studies indicate that TSP1 disrupts the endothelial barrier through EGFR/ErbB2 activation although additional signals are necessary in cells with low receptor expression., Data show that THBS1 was highly expressed at RNA and protein levels in LBW-ECFCs, and silencing THBS1 restored the angiogenic properties of LBW-ECFCs by increasing AKT phosphorylation., Data suggests that the presence of thrombospondin-1 (rs2228262) and thrombospondin-2 (rs8089) variants need not be considered a risk for coronary artery disease or myocardial infarction among South Indians., There are TSP-1 N700S polymorphisms in Chinese Zhejiang Han people, but might not be a risk factor for coronary artery disease., The TSP-1 A2210G polymorphism, which is a risk factor for myocardial infarction, is associated with small for gestational age pregnancies, suggesting that this polymorphism may associate with the risk of vascular disorders across the life course, Proteomic analysis of intra-arterial thrombus secretions reveals a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm., A statistically significant association between homozygous CC of THBS1 rs2292305 T>C and development of highly differentiated carcinoma., results clearly demonstrate that C5a/C5a des Arg needs both D binding protein and TSP-1 for maximal chemotactic activity, potential serological biomarker of breast cancer, Data show that p53 upregulated miR-194 expression in THBS1 retrovirus-transduced HCT116 cells, leading to decreased thrombospondin-1 (TSP-1) levels., transcript levels of UCHL1, COL1A2, THBS1 and TNFRSF10D were inversely correlated with promoter methylation, Nevertheless, despite its potent anti-angiogenic effect, our results suggest that circulating TSP-1 does not play a significant role in the pathogenesis of preeclampsia., Data suggest that intratumor disruption of the hypoxic cycle through thrombospondin 1 (TSP1) silencing will limit tumor invasion., Abnormal expression of HGF and TSP-1 may be related to malignant progression of ovarian cancer and associated in the pathogenesis of ovarian cancer., inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3 by decorin, Mutant 362Asn TSP1 had less than half of the ability of wild-type TSP1 to activate TGF-beta., TSP-1 expression seems to be associated with favorable biological behavior of breast carcinomas, Overexpression of THBS-1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma. THBS-1 may activate latent transforming growth factor-beta1 to stimulate fibroblasts to differentiate into myofibroblasts., Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein in the stromal elements of terminal villi and near villous vessels., New protein synthesis and trafficking through the Golgi are required for protein kinase C alpha-induced CD36 phosphorylation and blocked thrombospondin-1 binding, suggesting that phosphorylation probably occurs intracellularly., Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa., These findings provide evidence that CD148 functions as a receptor for TSP1 and mediates its inhibition of cell growth., The THBS1 single nucleotide polymorphism rs2292305 showed a weak association with the poor concentration symptoms of schizophrenia patients in a dominant model., TSP1 levels are associated with more vaso-occlusive events, hydroxyurea use &lower rates of hemolysis. High TSP1 concentrations may indicate higher risk of the viscosity/vaso-occlusion phenotype of sickle cell disease., Upreg'n of miR-17-92 cluster was seen in MYC-amplified AS compared to AS lacking MYC amplification and controls. Moreover, MYC-amplified ASs were associated with a significantly lower expression of THBS1 than AS without MYC amplification or controls., O-beta-N-acetylglucosaminylation can occur on secreted extracellular matrix proteins, These studies show that TSP1 regulated TGF-beta activity is a critical determinant of osteoblast differentiation., Aortic smooth muscle cell migration and proliferation in response to leptin is significantly inhibited by a TSP-1 blocking antibody, revealing the physiological significance of leptin-TSP-1 crosstalk., The authors propose that GRP-94, EGFR, fibronectin and TSP-1 are involved in the aggregative adherence of enteroaggregative Escherichia coli-T8 to INT-407 cells., Low plasma levels of TSP1 after percutaneous coronary intervention are associated with MACE., ECFC migration and tubulogenesis were stimulated neither by a TSP-HepI peptide with a modified heparin-binding site (S/TSP-HepI) nor when the glycosaminoglycans (GAGs) moieties were removed from the ECFC surface, TSP-1 and TGF-beta1 may play important roles in the progression of prolactinoma, by affecting angiogenesis., THBS1 SNPsrs1478604,rs11070217,rs2618162, rs1134485 & rs2228261 were associated with subclinical carotic atherosclerotic plaque thickness. A potential gene-gene interaction between vWF & THBS1 may associate with irregular plaque., study demonstrated the expression of inhibitor of apoptosis proteins, survivin and Livin and the pro-apoptotic protein TSP-1 in endemic Burkitt lymphoma (BL); no significant difference was found between BL and reactive lymphoid hyperplasia, NOL7 significantly alters TSP-1 expression and may be a master regulator that coordinates the post-transcriptional expression of key signaling factors critical for the regulation of the angiogenic phenotype., Our results demonstrate a HIF-1-dependent up-regulation of CD36 and TSP-1 that mediates the increased phagocytosis of neutrophils by macrophages during hypoxia., thrombospondin-1 regulation in hypoxia proved to be important for ccRCC cell migration and invasion., Pharmacological reversal of methylation silenced TSP1 had functional biological consequences in enhancing angiogenesis inhibition and inducing antitumor effects to decrease murine melanoma growth, Histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1., Rapid secretion of TSP-1 from MDA-MB-231 cells depends on ROCK1 inhibition., these data demonstrate that PRMT6 overexpression is associated with regulation of motility and invasion through up-regulation of TSP-1 and down-regulation of MMPs in human cancer cells., Low TSP1 expression is associated with low response to chemotherapy in non-small cell lung cancer., This study demonstrates that thrombospondin-1 is increased in adipocytes by coculture with macrophages and that the magnitude of the increase is dependent on the polarity of the cocultured macrophage., TSP-1 promotes lymph node metastasis and TSP-1 potentially could be a predictive marker for metastasis., human cytomegalovirus infection induced time-dependent decreases in mRNA and protein expressions of both TSP1 and TSP2 in astrocytes, [review] TSP-1 regulates matrix production and organization, thereby influencing tissue remodelling and promoting the generation of T regulatory cells that control the inflammatory response., THBS1 was elevated in ischemic muscle from peripheral artery disease patients. FoxO1 directly regulates THBS1 within ischemic muscle., Ovarian endometrioma increases TSP-1 in the surrounding ovarian tissues., Bioinformatic and deletion studies identified a 5' region of the TSP-1 promoter repressed by NR4A2 and proangiogenic transcription factors, including NF-kappaB and Ets1/2., We have identified the baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios as potential biomarkers of response in ABCP treated metronomically with Cy+Cel. This finding warrants its confirmation in a higher number of patients., Data indicate that the adhesive alpha-granule proteins fibrinogen and thrombospondin are concentrated in a fibrin polymerization-dependent "cap" on phosphatidylserine-expressing platelets that promotes their incorporation into thrombi., BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors., Anti-miR-182 could be used to restore TSP-1 expression in order to contrast angiogenic and invasive events in CRC, may play a role in the pathophysiology of preeclampsia, Data indicate that glioma cell migration is mediated by Thrombospondin-1 (THBS-1) and TGF-beta2., Inhibition of miR-21 blocks TSP-1-induced vascular smooth muscle cell migration, proliferation, and ERK 1/2 phosphorylation., Vn competes with hTSP-1 for binding to Atl repeats and vice versa. In conclusion, this study identifies the Atl repeats as bacterial adhesive structures interacting with the human glycoproteins hTSP-1 and Vn., Multiple microRNAs regulate thrombospondin 1 expression., TSP-1 inhibited angiogenesis potential of early and late endothelial progenitor cells in vitro. This inhibition may be regulated by TSP-1's interaction with CD47, resulting in down regulation of VEGFR2 phosphorylation., These results suggest that thrombospondin-1 binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase, limits vasodilation, and promotes renal ischemia reperfusion injury., IL-18 may act directly in prostatic hyperplasia pathogenesis by inducing TSP-1 production in prostatic smooth muscle cells via Akt phosphorylation., TSP-1 rs1478604 AA homozygotes may be at increased risk of corneal transplant rejection, especially if they carry the ACA haplotype., Genetic variation in the THBS1 gene results in decreased expression of glycoprotein TSP1 in ocular surface epithelial cells significantly increases the susceptibility to develop chronic ocular surface inflammation after refractive surgery., the TSP-derived 4N1K peptide effects on cell adhesion and integrin activation are independent of CD47, Integrin ligands and CXCL12 stimulated motility and enhanced cell surface expression of LRP1, intact TSP-1 and a 130,000 MW TSP-1 fragment while preventing formation of a de-adhesion-coupled 110 000 MW TSP-1 fragment., Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+dendritic cells., Authors found aberrant THBS1 protein expression in metastatic melanoma tumor biopsies., The critical step in establishing the angiogenic capability of human tumor cells is the repression of a key secreted anti-angiogenic factor, thrombospondin-1 (Tsp-1)., Observations suggest that the TSP-1 -696 C/T polymorphism may contribute to bladder cancer susceptibility in the Chinese population., TSP-1 cooperates with FGF-2 and VEGF/VEGFR-1 in determining melanoma invasion and metastasis, as part of a Slug-independent motility program., data revealed that both common and rare variants of the THBS1 gene are associated with risk for autism, suggesting that THBS1 is a novel susceptible gene for autism, The inhibitory effects of Cr(3+) on TSP-1 were accompanied by significant reductions in O-glycosylation of cytoplasmic and nuclear proteins., Adosine up-regulates TSP-1 production by macrophages, resulting in stimulation of angiogenesis, Th1 and Th2 cytokine responses differentially regulate T-cell expression of TSP-1 and LRP1 and motility., Polymorphism N700S (thrombospondin-1) does not represent a protective or risk factor for acute myocardial infarction in young Mexican individuals, Authors demonstrated that TSP-1 mRNA expression level was significantly upregulated in inflamed periodontitis gingival tissues, We conclude that EPB41L3, RASSF2 and TSP-1 genes are involved in the pathogenesis of diffuse gliomas, conclude that glioma cell-derived TSP1 facilitates the induction of TGF-beta in monocytes, CD133 expression and THBS1 expression were prognostic factors, and a negative relationship between HDAC and THBS1 was observed in advanced gastric cancer., Streptococcus pneumoniae interacts with matricellular human thrombospondin-1 (hTSP-1), facilitating adhesion to and invasion into host cells., TSP1 up regulation might be critically involved in the disease progression with rheumatoid arthritis., Triptolide can down regulates the expression of thrombospondin 1 and TGF-beta-1 in renal tubular cells. This plays a role in the pathogenesis of renal tubular fibrosis., Novel role of TNFalpha in inducing inflammatory stress response in human microvascular endothelial cells through Akt- and P38 MAPK-mediated expression of TSP-1, independent of NFkappaB signaling., The THBS1 N700S polymorphism was associated with coronary artery disease risk., determined if structural differences of the TSPs imparted different effects on vascular smooth muscle cell functions critical to the formation of neointimal hyperplasia, Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke, Serum THBS1 is a useful biological marker of obesity and metabolic syndrome in Japanese subjects, particularly in women. THBS1 may act as a critical circulating factor that couples obesity with metabolic syndrome and diabetes in humans, increased plasma thrombospondin-1 concentrations following ICH are independently associated with injury severity and short-term and long-term clinical outcomes, The anti-angiogenic activity of the native TSP-1 active fragment was maintained in the new TSP-1 mimetics and the results provide a new chemical approach for the design of TSP-1 mimetics., DLL4/Notch1 and BMP9 interdependent signaling induces endothelial cell quiescence via P27KIP1/thrombospondin pathway., In the current study Factor V Leiden, prothrombin G20210A, and thrombospondin-1 polymorphisms showed no association with severity of hepatic fibrosis.,
SP_COMMENT function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3., similarity:Belongs to the thrombospondin family., similarity:Contains 1 TSP C-terminal (TSPC) domain., similarity:Contains 1 TSP N-terminal (TSPN) domain., similarity:Contains 1 VWFC domain., similarity:Contains 3 EGF-like domains., similarity:Contains 3 TSP type-1 domains., similarity:Contains 8 TSP type-3 repeats., subunit:Homotrimer; disulfide-linked.,
transforming growth factor beta 1(TGFB1) transforming growth factor beta 1(TGFB1) Related Genes Homo sapiens
CHROMOSOME 19,
CYTOBAND 19q13.2, 19q13.2|19q13.1,
ENSEMBL_GENE_ID ENSG00000105329,
GENERIF_SUMMARY downregulates expression of integrin alpha6 in lens epithelial cells; gene expression regulation, Association of polymorphisms with genetic susceptibility to osteoporosis, Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis., Transforming growth factor beta-1 stimulates invasivity of hepatic stellate cells by engagement of the cell-associated fibrinolytic system, Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta, PAI-1 gene activation by TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5' proximal promoter., decrease in p21cip1 levels was mediated by a TGFbeta-initiated Ras-dependent, but smad-independent post-transcriptional mechanism, effect on renal function of polymorphism in heart transplant recipients, Human TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells., TGF-beta1 is the predominant isoform in lymphoid organs and regulates autoimmunity and inflammation. Smad proteins 2,3,4,6,& 7 are involved in its signal transduction pathways., The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells., induction in keratinocytes after gamma irradiation, TGFbeta can promote DNA instability through down-regulation of Rad51 and inhibition of DNA repair., Dendritic cells exposed in vitro to TGF-beta1 ameliorate experimental autoimmune myasthenia gravis.TGF-beta1 promotes dendritic cell differentiation and maturation., S. stercoralis patients with HTLV-I showed a high frequency of expression of TGF-beta-1, but those without HTLV-I did not., decreased levels of active TGFb in HIV, and immunosuppresed patients, and in patients with Pneumocystis carinii pneumonia, REVIEW, TGFbeta1-induced parathyroid hormone-related protein(PTHrP)mRNA stability might be, in part, the result of cis-acting sequences within the coding region of the PTHrP mRNA., Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1., common TGF-beta1 polymorphisms are not associated with a risk of developing Dupuytren's disease., TGF-beta 1 expression level can be a risk factor for alcoholic liver disease and might be related to the inflammatory activity and fibrosis of the liver in patients., down-regulated UPA in normal and dystrophic myoblasts; was the only growth factor tested able to exceptionally up-regulate PAI-1, mainly in dystrophic satellite cells; and induced a dose-dependent increase of Matrigel invasion only in dystrophic myoblasts, results suggest the importance of alphaEbeta7 expression by TGF-beta in selective localization of intestinal intraepithelial T lymphocytes, no correlation between the concentration of either isoform of TGFbeta in milk and the corresponding TGFbeta in plasma, production by different populations of erythroid cells derived from human embryonal liver, Transforming growth factor-beta1 enhanced smooth muscle actin expression in TR-PCT1 cells, but this expression was reduced by subsequent treatment with basic fibroblast growth factor., TGF-beta(1) expression was significantly correlated with both hepatic fibrosis and the percentage of portal tracts showing histological abnormalities associated with cystic fibrosis liver disease., TGF beta 1 was able to suppress the expression of Id-1, a helix-loop-helix (HLH) protein, which plays important roles in the inhibition of cell differentiation and growth arrest., TGF-beta1, TGF-beta2 and TGF-beta3 isoforms are produced by chondrosarcomas and could have a potential role as autocrine growth stimulators in these neoplasms, results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women, Signaling transduction induced by PF4 in erythroleukemia cells was compared with that induced by TGFB1, which is also a potent inhibitor of HEL growth., TGF beta1 expression and angiogenesis in colorectal cancer tissue., TGF-beta 1 induces apoptosis of primary cultured bronchiolar epithelial cells via caspase-3 activation and down-regulation of cyclin-dependent kinase inhibitor p21., Direct stimulation of tubular epithelial cells with TGF-beta(1)/epithelial growth factor results in an increased migratory capacity across bovine tubular basement membranes preparations., present in diabetic foot ulcers, induced in cicatricial pemphigoid, TGF-beta polymorphisms do not have a strong influence on disease onset or clinical progression in sarcoidosis and tuberculosis, although this polymorphism might have an effect on the immune response in a tuberculosis host, p38 MAP kinase regulation of AP-2 binding in TGF-beta1-stimulated chondrogenesis of human trabecular bone-derived cells, TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression, No significant variations in the distribution of the genotypes and haplotypes were observed between Alzheimer patients and controls., distribution of intracellular and extracellular expression in human testis and its association with spermatogenesis, HTLV-1 tax represses Smad-mediated TGF-beta signaling., Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads, Angiotensin II induces its promoter activation; has a similarity to hyperglycemia., TGFbeta1 regulates BGN expression and is part of a cell growth regulation pathway, TGF-beta1 gene are not suitable genetic markers of MVP in Taiwan Chinese., TGF-beta1 has a role in activation of endothelial cell apoptosis along with TNF-alpha, Data suggest that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of surfactant protein B gene transcription., Results demonstrate that TGF-beta1 stimulates matrix metalloproteinase-9 production and promoter activity in a process that depends of the activation of the Ras-ERK1,2 MAP kinase pathway., Differential effects of FGF4, EGF and TGFB1 on functional development of stromal layers (progenitor cell-outputs) in acute myeloid leukemia, TGFB1 has a smaller role than TGFB3 in endometrial differentiation, activation of TGF-beta1/Smad2 signaling is associated with airway remodeling in asthma, TGFbeta1 regulates GM-CSF induced human myelopoiesis, This protein increases E. coli K1 adherence, invasion, and transcytosis in cultured human brain microvascular endothelial cells., transforming growth factor-beta1 is closely related to the invasion and metastasis of colorectal cancer, Decrease of TGF-beta1 plasma levels and increase of nitric oxide synthase activity in leukocytes as potential biomarkers of Alzheimer's disease, TGF-beta1 inhibition of COL2A1 gene transcription in articular chondrocytes is mediated by an increase of the Sp3/Sp1 ratio and by the repression of Sp1 transactivating effects on that gene, TGF-beta1 regulates human enhancer of filamentation-1 expression, TGF-beta mediated G1 arrest requires P27, Kip1, in cancer cell line, In this study, the expression of Smad4 protein appeared to be correlated with the depth of invasion of esophageal SCC, Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation., 1,25(OH)(2)D(3) treatment of Caco-2 cells results in activation of latent TGF-beta 1 facilitated by the enhanced expression of IGF-II receptor, TGFbeta1 stimulated epithelial-mesenchymal transition of SiHa cells, indicating a positive role in the invasive transition of tumors., relationship to intragraft messenger RNA expression of angiotensinogen and to chronic allograft nephropathy in kidney transplant patients, expression of mRNA for IL-4, IL-5, TGF-beta1, IFN-gamma in patients with cicatricial pemphigoid, TGF-beta 1 in combination with IL-13 increases production of eotaxin-1 in airway fibroblasts from asthmatic and normal subjects., A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells., MKK3 activation is required for subsequent p38alpha and p38delta MAPK activation and collagen stimulation by TGF-beta1, TGF-beta1 is a potent inducer of HO-1 and examined the signaling pathway by which TGF-beta1 regulates HO-1 expression in human lung epithelial cells, induces TGFBI in pancratic cancer cell lines and in pancreatic cancer cells in vivo, Substance P up-regulates the TGF-beta 1 mRNA expression of human dermal fibroblasts in vitro, Levels of phosphorylated Smad2/3 are sensors of the interplay between effects of retinoic acid and TGF-beta or vitamin D3 on monocytic and granulocytic differentiation of HL-60 cells., HTLV1 Tax inhibits TGF-beta1 signaling by reducing the Smad3 DNA binding activity, children with active celiac disease have an altered expression of TGF-beta1 and TGF-beta3 in the small intestine, involvement of Furin gene regulation in the maturation of TGFB1 in differentiating megakaryoblastic cells, TGF-beta(1) might regulate the TARC-related inflammatory processes, which may be important for understanding the pathogenesis of allergic diseases., the molecular mechanisms by which autocrine TGF-beta may selectively contribute to tumor cell motility, Polymorphism in this gene affects immunosuppression in stable kidney transplantation., Codon 10 and codon 25 polymorphism affect gene expression and protein synthesis in stable renal allograft recipients., The role of TGF-beta1 and -beta3 in generating a high TIFP was investigated in xenografted experimental anaplastic thyroid carcinoma (ATC) derived from the human ATC cell line, decreased ability to modulate Th1 response in mucosal leishmaniasis, LMP1 inhibits transforming growth factor-beta 1-mediated induction of MAPK/p21 in Epstein-barr virus infected gastric epithelial cell line GT38, Urinary TGF-beta1 and Amadori albumin were elevated in patients with micro- or macroalbuminuria, Localization of TGF-beta(1) mRNA and protein within tubular epithelial cells, with its increased urinary excretion in nephrotic syndrome, suggest the activation of these cells by filtered protein towards increased TGF-beta(1) production., Data demonstrate that Egr-1, AP1 and Smad are part components of the transforming growth factor beta signal transduction pathway that regulates PPAR gamma expression., may contribute to a reduction of proteolytic activity of human gingival fibroblasts in Cyclosporin A-induced gingival overgrowth which favors the accumulation of extracellular matrix, Exposure of human skin diploid fibroblasts to repeated subcytotoxic doses of ultraviolet-B induces its mRNA overexpression, cigarette smoke-induced oxidative stress and TGF-beta(1) modulate expression of the cell cycle inhibitor p21(waf1/cip1), TGF beta 1 signaling and stimulation of osteoadherin in human pulpal fibroblasts and in early secretory and mature odontoblasts., investigated TGF-beta 1, -beta 2, and -beta 3 latency-associated peptides (LAP)expression in sound and carious human teeth, An examination of quantitative gene expression of this protein in the renal artery wall of chronically rejected human renal allografts., mutations in the signal peptide and latency-associated peptide of TGF-beta1 facilitate TGF-beta1 signaling, Genetic variation at the TGF-beta 1 locus is unlikely to confer significant susceptibility to advanced diabetic nephropathy in patients with type 1 diabetes mellitus., results indicate that cervical cancer cells affect the amount and the composition of the intratumoral stroma and the tumor infiltrate by the production and secretion of transforming growth factor-beta(1), transforming growth factor-beta (TGF-beta) signaling is modulated by endogenous sphingolipid mediators, TGF-beta signal transduction and mesangial cell fibrogenesis. Review., the role of Smad proteins in TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation, downregulated Notch2 expression in cultured human dental slices, TGF-beta1 up-regulates expression of integrins and fibronectin, an effect that is associated with autophosphorylation/activation of focal adhesion kinase., Data show that high glucose alters endothelial cell growth, apoptosis, and cell cycle progression, but not apoptosis and endoreduplication, via a transforming growth factor-beta1 autocrine pathway., fibroblast transcriptional programming in response to TGF-beta1 during development, oncogenesis, tissue repair, and fibrosis, transforming growth factor-beta1 was produced in follicular and luteal phases and stimulated cell proliferation mainly in leiomyoma cells, Results suggest that the destabilization of interferon-gamma (IFN-gamma) mRNA induced by transforming growth factor beta leads to the inhibition of antiviral activity and IFN-gamma production in interleukin-18-stimulated LNK5E6 cells, TGF-beta1 signaling potentiates renal tubular epithelial cell apoptosis by a Smad-independent, p38 MAP kinase-dependent mechanism., Transforming growth factor beta1 (TGF-beta1) plays a central role in wound healing and fibrosis and has been implicated in the pathogenesis of keloid disease and hypertrophic scar., Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients., Transforming growth factor beta overexpression is associated with advanced stage gallbladder cancer, TGFB1 treatment of ECV304 cells increased bacterial cell adhesion., TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue., by inhibition of cell migration, increased expression of TGF-beta1 after ischemia delays recovery of proximal tubule structure and function., Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome., TGF-beta1 expression in peritoneal fibroblasts was increased by hypoxia and/or TGF-beta1 stimulation, favoring adhesion development., TGF-beta1 inhibited IFN-gamma and TNF-alpha-induced TARC production in HaCaT cells via Smad2/3. Modulation of TGF-beta/Smad signaling pathway may be beneficial for treatment of atopic dermatitis., TGF-beta1 potentiates Abeta production in astrocytes and may enhance the formation of plaques burden in the brain of Alzheimer's disease patients, Hip, lumbar spine and wrist fracture incidence for women with the TGF-beta1 Leu/Leu genotype was not significantly different when compared with that for women with Leu/Pro genotype., Pro10 allele in the TGF-beta(1) gene pathway might contribute to prevalent diseases such as obesity and type 2 diabetes mellitus., expressed in acute respiratory distress syndrome, The C(-1348)-T and T(29)-C polymorphisms were distributed similarly in osteoporotic patients and normal controls, however, the rare genotypes were associated with higher bone mass at the hip., G2 arrest induced by TGF beta1 in the Rb-negative hepatoma cell line and compared with G1 arrest in the Rb-positive hepatoma cell line, Our results suggest that TGF-beta T869C (Leu 10Pro) gene polymorphism is associated with diabetic nephropathy in Chinese., TGFb has a role in stimulating Sp1, which results in up-and down-regulation of UGDH, Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells., THP-1 monocytic cells cultured in the presence of TGFB1 show decreased phagocytosis toward IgG-coated sheep red blood cells, suppressed expression of common gamma-subunit and signaling properties of FcgammaR, and downregulated MCP-1 production., Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells., may be one of the most important factors in the regulation of the [gingival inflammatory} infiltrate and in the production of tissue repair with a stimulation of fibroblasts and endothelial cells, role in genetic susceptibility of tuberculosis, TGF-beta 1 increases glucocorticoid binding and signaling in inflammatory cells through a Smad 2/3- and AP-1-mediated process., TGFbeta transcriptionally regulates tristetraprolin in human T cells, Glucocorticoids significantly inhibited TGF-beta1 and TGF-beta2 production and reduced expression of the up-regulated TGF-beta1 and TGF-beta2 mRNA induced by exogenous TGF-beta1, -beta2, or -beta3, TGF-beta1-controlled reduction in SDF-1 expression influences bone marrow cell migration and adhesion, which could affect the motility of cells trafficking the bone marrow., Certain specific cytokine genotypes for TGF-beta1, IL-10, and TNF-alpha are not associated with chronic allograft dysfunction. Normal kidney with low TGF-beta1 genotype at codon 10 had lower TGF-beta1 mRNA., TGF-beta1 may be involved in activation of cdk inhibitor p21WAF1 in gastric adenocarcinoma, promoter may have a small effect on the modulation of the inflammatory process during periodontitis, An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 and fibronectin., This is a novel mechanism of TGF-beta 1 inhibition requiring early G(1) induction and stabilization of p21 protein, which binds to and inhibits cyclin E-CDK2 and cyclin A-CDK2 kinase activity rather than direct modulation of cyclin or CDK protein levels., transforming growth factor-beta signaling is regulated by protein inhibitor of activated STAT, PIASy through Smad3, TGF-beta and IGF-II in the bone microenvironment coordinately amplify IGF-I bioavailability through controlled IGFBP-4 proteolysis, which may be a means to promote bone formation., TGF-beta1 upregulates VDUP1, gene expression profiling in epidermolysis bullosa acquisita, Transforming growth factor-[beta]1 polymorphism is not a factor associated with the occurrence of ossification of the posterior longitudinal ligament [OPLL], but related to the area of the ossified lesion. The "C" allele might be a risk factor, the R218C mutation increases TGFbeta1 bioactivity and enhances osteoclast formation in vitro, a time-dependent release of TGFB and PDGF-AB occurred at neutral and alkaline pH, but not pH5, 15 min and 12h after platelet activation, suggesting relevance to wound healing, Serum levels of both bFGF and TGF-beta1 were found to be significantly higher in chronic lymphocytic leukemia., TGFbeta1 polymorphisms do not play a role in the pathogenesis of systemic sclerosis, but they may be a risk factor for genetic susceptibility to pulmonary fibrosis., TGF-beta1-mediated collagen I accumulation is associated with cytoskeletal rearrangement and Rho-GTPase signaling, These data provide evidence for a functional role for integrin alphavbeta8-mediated activation of transforming growth factor-beta in control of human airway epithelial proliferation in vivo., the antiproliferative effect of TGFbeta is decreased by epidermal growth factor in primary human ovarian cancer cells, After acceleration of regenerative response by HGF, subsequent elevation of TGF-beta1 synergistically controls graft size, regulating uncontrolled proliferation of hepatocytes., TGF-beta1-mediated MAP kinase activation controls WNT-7A gene expression and Wnt-mediated signaling through the intracellular beta-catenin-TCF pathway, Neutralizing anti-TGF-beta1 antibody reversed the inhibition of keratinocyte proliferation., low serum leptin, high serum TGF-beta1 and sOb-R levels, and elevated urine leptin concentrations were observed at the onset of minimal change nephrotic syndrome, the ligand-binding domain of GR, but not the DNA-binding domain or the N-terminal activation domain, is required for GR-mediated transrepression of TGF-beta transactivation, All three TGF-beta isoforms have fibrogenic effects on renal cells. TGF-beta2 and TGF-beta3 effects may be partially mediated by TGF-beta1. Blockade of all isoforms together may yield best therapeutic effect in reducing renal fibrosis., Polymorphisms in TGF-beta1 influence risk for hemodialysis access failure. By inducing synthesis of extracellular matrix proteins, overproduction of TGF-beta1 may accelerate intimal hyperplasia, resulting in fistula stenosis and subsequent access failure., transforming growth factor-beta signaling is inhibited by interferon gamma through direct interaction of YB-1 with Smad3, Four novel polymorphisms in TGFB1 are found not associated with spinal bone mineral density in postmenopausal Korean women., TGF beta1 regulates cell cycle proteins and may induce multiple independent signals to check the proliferative potential of human trophoblastic cells and allow their functional differentiation, a new function of TGF-beta1, which is to promote undifferentiated keratinocyte amplification, Genetic and immunohistochemical studies convincingly suggest a link between TGF-beta 1 and the pathogenesis of autoimmune-associated congenital heart block., TGF-beta1 in cartilage is active in periods of skeletal immaturity and is closely associated with increases in chondrocyte UDPGD activity, signaling in keratinocytes is regulated by glycosylphosphatidylinositol-anchored proteins, Plasma TGF-beta1 levels of thrombocytopenic neonates were significantly lower than those of healthy nonthrombocytopenic neonates but did not differ significantly from nonthrombocytopenic neonates with similar perinatal risk factors for thrombocytopenia., Biological dressing effect of cultured epidermal sheets(CESs) is mediated by EGF family, TGF-beta, and VEGF., In the confluent state, TGF-beta1 and TGF-beta2 stimulated the cells to progress to the S-phase of the cell cycle through platelet-derived growth factor-B (PDGF-B) chain production and protein kinase C., sumoylation of Smad4 was strongly enhanced by TGF-beta-induced activation of the p38 MAP kinase pathway but not the Smad pathway, DACH1 bound to endogenous NCoR and Smad4 in cultured cells; Smad4 was required for DACH1 repression of TGF-beta induction of Smad signaling, Found in renal artery of kidney allografts in chronic rejection., a signal transduction cascade of the TGF-beta/Smad signaling pathway, which is activated in the GEC, appears to be involved in the development of focal segmental glomerulosclerosis, there is a TGF-beta1-activated pro-survival/anti-apoptotic signaling pathway in mesenchymal cells/fibroblasts, Mortal and early immortal stages of both cell lineages displayed growth reduction upon exposure to TGF-beta1., ANG II-induced activation of latent TGF-beta1 in human mesangial cells operates via TSP-1, effect of restoring the growth-inhibitory autocrine circuit in epithelial cancer cells that have retained sensitivity to growth inhibition by TGF-beta1 but which produce and secrete insufficient amounts of endogenous peptide, TGF-beta 1 also activates the mitochondrial pathway showing Bid-mediated loss of mitochondrial membrane potential and subsequent cytochrome c release associated with the activations of caspase-9 and the effector caspases., TGF-beta1 is a negative regulator of NF-kappaB activation in the gut, transforming growth factor-beta 1 gene polymorphism is associated with prostate cancer and benign prostatic hyperplasia, The physical appearance of endometriotic implants and the severity of dysmenorrhea appear to be related to the expression of TGFbeta1 in nerve fibers., findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors, The worse the cancer cell differentiation and lymph node metastasis, the more over-expression of TGF-beta1., TGF-beta acts as an endogenous, radiation-inducible radioresistance factor in esophageal carcinoma cells, There was increased TGF-beta 1 mRNA expression in the stenotic tissue after clinical ureteropelvic junction obstruction. Alteration of TGF-beta 1 expression may be involved in the pathogenesis of congenital hydronephrosis., TGF-beta and Smad3 mediate beta-hydroxybutyrate-induced cell cycle-dependent growth inhibition in the human proximal tubule (HK-2 cell), Glucose induces an early increase in TGF-beta 1 transcription via activation of p38MAP kinase. In addition, glucose causes a late increase in PDGF-dependent TGF-beta 1 translation by enhancing cellular sensitivity to PDGF., transforming growth factor-beta regulates the Kindler syndrome protein, transcription upregulated directly by Hepatitis C virus core protein in parenchymal cells and suggests a new paradigm for exacerbation of liver fibrosis by HCV infection, Stimulation of vascular endothelial cells with TGF-beta1 induced marked increase in the expression level of HAS2 mRNA and protein., The above results indicate that PKB-Ser-473 and FAK-Tyr phosphorylation stimulated by TGF-beta1 are both dependent on cell adhesion., The combination of high AT and TGF-beta1 producing polymorphisms is associated with advanced hepatic fibrosis in obese patients with non-alcoholic fatty liver disease, findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta, Treatment of premyelinating aggregate rat brain cultures with recombinant human TGF-beta 1 results in greater accumulation of myelin basic proteins and FGF-2 and PDGF-AA production., Endogenous TGF-beta plays an important role in the cell cycle arrest of c-kit(high) but not c-kit(low/-) cells in CD34+ CD38- cells., results indicated that TGF-beta1-promoted cell adhesion and TGF-beta1-induced epithelial-to-mesenchymal transformation might be both responsible for TGF-beta1-enhanced cell migration, ability of TGF-beta1 to polarize the differentiation of HPCs induced by IL-3 towards LC development, although IL-3 DCs were unable to form BGs partly because of their poor ability to induce Langerin, role in urokinase up-regulation and promotion of ovarian tumor invasion, TGF-beta regulates IL-4 signaling by targeting NF-kappaB signaling, Review. the role of the anti-inflammatory cytokine transforming growth factor beta in atherosclerosis, expression values for TGF 1 and its receptors I, II, and III were twice as high in the group of patients with a diagnosis of high-grade lymphomas as in the group of patients diagnosed with low-grade lymphomas, Suppressor function of human CD4+CD25high regulatory T cells involves a TGF-beta 1-dependent mechanism., TGF-beta is transcriptionally repressed by c-Ski protein in esophageal squamous cell carcinoma, TGF-beta(1) expression in bronchial mucosa may play a role in bronchial subepithelial fibrosis in eosinophilic bronchitis (EB) patients., TGF-beta signaling is disturbed by Smad7-Smurf-mediated negative regulation in fibrotic disorders, We demonstrated that TGFbeta1 repressed FGF10 promoter activity in primary prostatic tissue, via a region of the promoter containing an Sp1 binding site., TGF-beta has a role in radiation-induced fibrosis and is inhibited by halofuginone, examination of inactivation in thyroid nodules by gene expression analysis, TGFbeta, which is abundant in the bone matrix, directly induce mononuclear phagocyte osteoclast precursors to differentiate into osteoclastic cells capable of lacunar resorption, inhibitory signals induced by IL-3 on breast cancer blood vessel assembly were abrogated by the addition of the neutralizing TGF beta antibody, a new molecular mechanism linking with up-regulated TGF-beta1 promoter activity, a novel mechanism of control of TGF-beta action that may be important in fibrosis, HIV-infected lymphocytes indirectly contribute to lymph node remodeling by secretion of TGF beta 1, which increases fibronectin synthesis by fibroblasts., TGF-beta function is abrogated in vivo by SCF(beta-TrCP1) which decreases Smad4 stability, TGF-beta1 is highly expressed in hairy cells and is directly involved in the pathogenesis of bone marrow reticulin fibrosis in hairy cell leukemia, Jab1/CSN5 as an adapter that targets Smad7 for degradation, thus releasing Smad7-mediated suppression of TGF-beta1 signaling., TGFbeta and Wnt ligands have roles in regulating differentiation and cell fate determination [review], a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-beta involving Smad3/4, Sp1, Ets1, and CBP/p300, TGF-beta functions as a classic embryonic inducer, initiating a cascade that is controlled by other factors in the cellular environment., polymorphisms in TGF-beta1 have a role in development of breast cancer, HIV infection resulted in a significant increase of plasma TGF-beta(1) concentration compared to healthy individuals (11.4 +/- 6.8 vs. 6.1 +/- 1.5 ng/mL, p < 0.01), suggestive of an immunosuppressive role in HIV pathogenesis., High expression of TGF-beta1 may be involved in the incidence of lung cancer., MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral squamous cell carcinoma, Recombinant human TGF-beta 1 signals through multiple murine intracellular signaling pathways to inhibit T cell expansion., In prostatectomy patients, preoperative plasma levels of TGF-beta(1) and IL-6sR are associated with metastases to regional lymph nodes and disease progression., overexpression of HER2 in nontumorigenic mammary epithelial is permissive for the ability of TGF-beta to induce cell motility and Rac1 activity and HER2 and TGF-beta signaling cooperate in the induction of cellular events associated with tumor progression, coiled coil-induced dimerization of the ectodomains stabilize their interaction with TGF-beta as compared with the monomeric ectodomains, certain pathological condition-induced TGFbeta1 overexpression in the skin may synergize with or induce molecules required for the development of Th1 inflammatory skin disorders, TGF-beta 1 polymorphisms at positions -509, +869 (codon 10), and +915 (codon 25) do not play a dominant role in alcoholic chronic pancreatitis, sustained activation of p44/42 MAPK perhaps forms the stimulatory signal induced by low TGF-beta1, whereas activation of p38 forms the inhibitory pathway, TGF-beta1 inhibited the growth of most nontransformed cells. Many cancer cell lines were insensitive to this effect. It induced Smad2 phosphorylation in the majority of cell lines, including those resistant to TGF-beta1-mediated cell-cycle arrest., The K allele of KLK1 promoter and TT genotype of TGF-beta1 may be a genetic KLK1 -130 GN and -128 G-C, and the susceptibility factor contributing to progressive renal deterioration in Taiwanese primary vesicoureteric reflux children., TGF-beta and IL-2 trigger a cytokine-dependent self-perpetuating loop to sustain specific T regulatory cell suppressive activity., blood TGF-beta 1 has a role in preventing progression of esophageal neoplasms, combined production of the immunosuppressants IL-10 and TGF-beta, as well as coexpression of TGF-beta RI and RII (required for cellular response to TGF-beta), may act to down-modulate host anti-Mycobacterium tuberculosis immunity, increase of serum immunoglobulin A in newborns during 1 month of life was well correlated with levels of both transforming growth factor-beta1 and transforming growth factor-beta2, TGF-beta1 may play a key role in liver fibrogenesis., dual signaling pathways involving TGF-beta1, an antiapoptotic pathway mediated by the Smad pathway involving p21, and an apoptosis-permissive pathway mediated in part by p38 MAPK., transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways require MSK1, Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis, TGFB1 polymorphism may play a role in advanced stage prostate cancer., Endothelial cell vessel assembly requires TGFB1 signaling transduction pathways., TGF-beta1 mRNA and protein are specifically upregulated in carcinoma-associated fibroblasts, some SNP's are associated with chronic obstructive pulmonary disease, identified as being responsible for downregulation of gap junctional intercellular communication via an increase in the level of reactive oxygen species in stromal fibroblasts, AGE- (advanced glycation end-products)& TGF-beta-mediated signals, by converging on STAT5 activation & p21waf expression, may regulate mesangial cell growth., upregulation of MUC4 by TGF-beta is restricted to well-differentiated pancreatic cancer cells, and point out a novel mechanism for TGF-beta as a key molecule in targeting MUC4 overexpression in pancreatic adenocarcinomas., results indicate a new interaction partner for the alpha(v)beta(3) integrin, the TGFbetaIIR, in which TGFbeta1-induced responses are potentiated in the presence alpha(v)beta(3) ligands, incubation of NK cells and LAK cells with TGF-beta1 resulted in dramatic reduction of surface NKG2D expression associated with impaired NK cytotoxicity, TGF-beta1 gene polymorphisms are specifically associated with heavy proteinuria and mesangial cell proliferation in Japanese patients with IgA nephropathy, although they do not confer susceptibility to this disease., TGFbeta1, 2 and 3 mRNA expression correlates with the developmental growth of the prostate, and potentially effect smooth muscle distribution., TGF-beta has a role in activation of the MAP kinase signaling system resulting in cell cycle progression in tumor cell lines, The G/C substitution at codon 25 was associated with an increased risk for prevalent vascular disease, new onset cardiac morbidity, and cardiac mortality in HD patients, and may be a genetic susceptibility factor for the development of atherosclerosis., Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression, The genetic differences in codons 25 and 263 suggest that TGF-beta1 could play an important role in occurrence of clefts of the lip, alveolus, and palate, however, functional experiments will be required to confirm the mechanisms of disturbed development., Patients with RHD have a lower frequency of TGF-beta1 C-509T CC genotype and a higher frequency of T869C T allele, which supports a role for these polymorphisms in determining the risk/protection of RHD in Taiwan Chinese patients, acyl-coenzyme A, part of an autocrine/paracrine system involved in the regulation of COX-2 expression in the distal pulmonary circulation, Patients with Systemic lupus erythematosus (SLE) had lower serum levels of TGF-beta1 compared with controls, cyclic AMP inhibits umbilical vein endothelial cell angiogenesis indued by TGFB1., TGF-beta1 overexpression at early stages of head and neck squamous cell carcinoma formation provides a tumor promoting microenvironment., TGF-beta1 and integrin stimuli interact prior to Smad2 and 3 phosphorylation in the cytoplasm of chondrocytic cells and regulates the expression of ECM components in chondrocytes., TGF-beta1-induced pericellular collagenolysis is controlled by MT1-MMP activity, which is regulated by ERK 1/2- and p38 MAPK-modulated TIMP-2 expression, Differentiated macrophages play protective role in pathophysiology of gout. Macrophage TGFbeta1 is mediator of paracrine suppression during resolution phase of inflammation., TGF-beta and ET-1 have roles in mechanical force generation in keratinocyte-fibroblast co-cultures, and GM-CSF induces myofibroblasts acting indirectly, autocrine TGF-beta regulates the cell cycle through a pathway different from exogenous TGF-beta in the sense that p21 is a more sensitive effector of the TGF-beta signaling pathway, heightened ERK and PKCdelta activity in high ambient glucose conditions interact with the Smad pathway, leading to enhanced responsiveness to TGF-beta1 and increased extracellular matrix production in mesangial cells., TGF-beta1 may play an important role in the process of plaque stabilization., Our results indicate that TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in focal segmental glomerulosclerosis, Polymorphic in pancreatitis., HCV viral proteins interact with the TGF-beta signaling mediator Smad3 and differentially impair TGF-beta/Smad3-mediated transactivation and growth inhibition., involvement of TGFbeta1 in the development of endothelial cell response to high glucose in terms of chondriotin sulfate accumulation and cell binding to hyaluronic acid., Data show that the WSXW motif binds the VLAL sequence on both latency-associated peptide and mature TGF-beta, and these interactions are critical for thrombospondin-1-mediated activation of the TGF-beta latent complex., critical roles for interleukin-4 and IL-12 in regulating 4-1BB effects on TGF-beta1-mediated suppression, An association between T29 -C polymorphisms of TGF-beta1 gene and BMD, bone turnover and fragility fractures were demonstrated in postmenopausal southern Chinese women., C-509T and G-800A polymorphisms are not associated separately or in haplotype combinations with early implant failure, TGF-beta 1 significantly downregulated CFTR mRNA and cAMP-dependent current in nasal polyp cultures; data suggests that chronic inflammation in nasal polyposis downregulates CFTR gene and protein expression, Patients with renal cell carcinoma have enhanced expression of TGFB1 mRNA and protein in tumor samples and increased serum levels of TGFB1., chronic active Epstein-Barr virus infection T-cells are activated to transcribe IFN gamma, IL-10, and TGF beta excessively, and the latter two genes are expressed preferentially in the EBV-infected subsets, TGF-beta(1) stimulation of human biglycan mRNA expression relies on increased transcription of the biglycan gene, and is mediated by members of the Sp1 family of transcription factors., FcepsilonRI+ on dendritic cells is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases., TGF-beta 1-stimulated CTGF expression is mediated by mechanisms involving ERK and JNK pathways and is downregulated by IL-4 and IL-13 through modulation of Smad and ERK signals., may play an important role in the metastatic proclivity of selected tumor types, The TGFB1 T+869C (Leu10Pro) gene polymorphism is associated with multiple sclerosis susceptibility, especially in males., disruption of signaling by interfering with the recruitment of CREB-binding protein into transcription initiation complexes on TGF-beta-responsive elements, TGF-beta is not involved in early phase growth inhibition by 1alpha,25(OH)(2)D(3), VEGF attenuates TGF-beta action in the human endothelial cell, specifically at the level of transcription of PAI-1 gene and Smad2/3 phosphorylation, Bikunin neither decreased expression of TGF-beta receptors (TbetaRI and TbetaRII) in cancer cells nor altered the specific binding of 125I TGF-beta1 to the cells., inhibition of transforming growth factor-beta activation is required for stimulation of vascular smooth muscle cell proliferation and migration by apolipoprotein(a), Extracellular matrix ECM production can be stimulated independently by hypoxia and TGF beta 1., key dependence of the fibrogenic actions of CTGF on TGF-beta in kidney, Blocking TGF-beta may have important hemodynamic effects that are relevant to treating diabetic nephropathy., TGF-beta1 gene polymorphisms is associated with renal allograft rejection, Genetic variation of the TGF-beta1 gene may affect longevity; haplotype combination (G -800/C -509/C 869/C 915) was notably lower in centenarians than in younger individuals, TNF-alpha stimulation of PTC in the presence of BMP-7 failed to increase monocyte-dependent TGF-beta1 stimulatio, No significant differences were observed in the genotype distribution of the three TGF-beta1 polymorphisms between patients and controls., TGF-beta1 polymorphisms are associated with end-stage renal disease, particularly in patients with associated clinical cardiovascular disease, and could be useful as genetic markers of chronic renal disease and higher cardiovascular risk., induced by R5 HIV-1 infection of fetal thymic organ culture (FOTC) which in turn induced CCR5 expression, H-ras and TGF-beta signal pathways interact with each other in MCF10A human breast cells may provide an insight into molecular mechanisms for contribution of TGF-beta to a malignant progression of breast cancer in collaboration with activated H-ras, caspase-3 is crucial for the differentiation of bone marrow stromal stem cells by influencing TGF-beta/Smad2 pathway and cell cycle progression, negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer, the leiomyoma and myometrial smooth muscle cells molecular environment is targeted by the autocrine/paracrine action of TGF-beta, TGF-beta1 affects both proliferation and apoptosis of gastric cancer cells through the regulation of p15 and p21, and induces transient expression of Smad 7 as a negative feedback modulation of TGF-beta1 signal., internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells, TGF-beta1 blocks the NF-kappaB activation and cytokine release that is stimulated by ligands for TLRs 2, 4, and 5, Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression, Daxx suppresses Smad4-mediated transcriptional activity by direct interaction with the sumoylated Smad4 and has a role in regulating transforming growth factor beta signaling, TGFbeta1 can induce increased expression of both SPARC and type I collagen. Specific inhibition of SPARC led to decreased expression of type I collagen and attenuated the profibrotic effect of TGFbeta1 in cultured normal human fibroblasts., TGFbeta produced by keratinocytes contribute to selectively downregulate CD1d expression on intraepidermal-resident Langerhans cells, Langerhans cells may resist activation by human papillomavirus-like particles in normal epithelium abundant in TGF-beta, but not in situations in which TGF-beta concentrations are reduced, Adrenomedullin can attenuate TGF-beta1-mediated renal tubulointerstitial extracellular matrix turnover via an antagonistic mechanism of inhibitory Smad6 in TGF-beta1-elicited signaling., A role for TGF-beta1 in UVB-induced premature senescence in skin fibroblasts., Ca(2+) entry mode operation of the Na(+)/Ca(2+) exchanger is required for des-Arg(10)-kallidin- and TGF-beta1-stimulated fibrogenesis and participates in the maintenance of the myofibroblast phenotype, Inflammatory cytokine different from TGF-beta1 may differently orchestrate cell fate in AAT and smoking-related emphysema types., the level of Smad6s can alter the level of TGF-beta and the subsequent induction of PAI-1 via a FoxD1 transcription site, Hepatic progenitor cells are resistant to the proliferative and apoptotic effects of TGFb1, Compared to normal population, the frequencies of genotypes producing high TGF-beta1 protein were higher in IgAN patients, and patients with genotypes showed a poor renal survival rate., augmented in gingival crevicular fluid of smokers with chronic periodontitis, TGFbeta1/Smad3 suppresses BRCA1-dependent DNA repair in response to a DNA damaging agent, Continuous secretion of TGFB1 by cell-mediated gene therapy maintains chondrocyte redifferentiation., implicated in the deposition of excessive extracellular matrix in the vessel wall, contributing to atheromatic plaque, the genetic polymorphism in codon 10 of the TGF-beta1 gene may play a role in hepatocellular carcinoma development in patients with chronic hepatitis B infection., results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC, examined the signal transduction pathways by which TGF-beta induces hyaluronan synthesis in normal orbital fibroblasts, orbital fibroblasts from patients with Graves' ophthalmopathy, and abdominal fibroblasts, a specific cross-talk between TGF-beta1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells, it is reported in this study that TGF-beta induces binding of HTLV virions and expression of glucose transporter type 1 in primary CD4(+) T lymphocytes that remain quiescent, Through adenoviral gene transfer technology, we describe a novel mouse model of colitis and implicate TGF-beta1 in the pathogenesis of obstructive intestinal fibrosis., Smad7-mediated inhibition of NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation., TGF-beta1 polymorphism may determine the progression of joint distraction in rheumatoid arthritis patients., TGF-beta signaling suppresses nuclear export of Smad4 by chromosome region maintenance 1 and targets Smad4 into the nucleus; mutations in Smad4 that affect its interaction with Smad2 or Smad3 impair nuclear accumulation of Smad4 in response to TGF-beta, TGF-beta1 polymorphisms are associated with fibrosis progression in Caucasians chronically infected with hepatitis C., Functionally relevant genetic variants of the TGF-beta1 gene are not associated with nonalcoholic chronic pancreatitis., TGF-beta 1 polymorphism may modify individual susceptibility to breast cancer in premenopausal Korean women, Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition, Transforming growth factors beta (TGF-betas) are multifunctional cytokines that modulate cell growth, differentiation and apoptosis, Cerebral glucose utilization is reduced preferentially in transgenic mice overexpressing TGF-beta 1 and showing Alzheimer's disease-like cerebrovascular abnormalities., Glucose-mediated transforming growth factor-beta1 release in human mesothelial cells is endothelin independent., Results demonstrate that transforming growth factor-beta induces endothelin-1 expression by a functional cooperation between Smads and activator protein-1 through activation of the Smad signaling pathway., TGF-beta 1 suppresses not only the acquisition but also expression of effector function on memory CD8 T cells and tumor-infiltrating lymphocytes reactive against melanoma and can hinder the therapeutic benefits of cancer vaccination and immunotherapy., TGF-beta/Smad3 signaling is required for hypoxia-mediated inhibition of adipocyte differentiation in marrow stromal cells, TGF-beta1 concentration may predict the development of kidney graft fibrosis., TGFbeta1 transfected smooth muscle cells conditional medium produced significantly more endothelial colonies (P<0.05). The adhesion force between endothelial progenitor cells and smooth muscle cells in TGFbeta1 group was higher than control., The activation of c-Src by TGF-beta1 is EGFR dependent and is required for full Akt phosphorylation and cell survival, Findings suggest that the TGF-beta1 gene polymorphism does not predispose to the development of refractory anemia, but may affect disease progression., Recombinant human TGF-beta 1 inhibits priming phase IFN-gamma expression in part through inhibition of Stat4 expression, but inhibits Th1 effector phase IFN-gamma expression through inhibition of T-bet expression., TGF-beta1 gene therapy blocks islet destructive autoimmunity, facilitates islet regeneration, and cures diabetes in diabetic NOD mice., Tsc-22 modulates the TGF-beta-dependant signaling pathway, Might play significant role in physiology of trabecular meshwork and contribute to pathological changes of this tissue in certain forms of glaucoma., Human TGF-beta2 but not human TGF-beta1, or -beta3 promotes cardiac myocyte differentiation from mouse ES cells., Insensitivity to TGF-beta in some prostate cancer cells is due to promoter methylation in TbetaRs, TGF-beta1 inhibits hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cells, TGF-beta 1 could make a difference regarding prognosis and prediction in breast cancer patients if it were evaluated in relation to the status of the tumor markers estrogen receptor and epidermal growth factor receptor 2 (HER-2), Blood levels increased in acute viral hepatatitis, shich may be connected with the degree of hepatocyte damage., expression and the activity of TGF beta1 signalling components in B cell lymphoma cell lines (e.g. HT 58 cells) and in isolated human peripheral mononuclear cells from healthy individual's and B-CLL patient's blood, Repression of fgf8 might be directly or indirectly involved in this transcriptional control by TGF-beta., in a model system, TGF beta-1 released from activated platelets contributes to the hemostatic imbalance at the sinusoidal endothelium in patients with hepatic VOD by increase of endothelial cell PAI-1 production and TF expression., The high expressions of TGF-beta1 and TGFbR1 play important roles in spontaneous abortion., results of this study indicate that IFN-gamma may contribute to the development of type 2 diabetes, based on a combination of molecular and immunological observations, Significant differences between chronic kidney failure(CKF) and controls in allele frequencies of two SNPs, Leu10Pro and C-509T and in haplotype distributions, indicating association with susceptibility to CKF., TGF-beta1 low-production genotypes were associated with an increased odds of disease relapse in breast cancer, AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism, HHT is an angiogenic disorder characterized by an over-expression of VEGF, TGF-beta1 and ALK1, No differnce in haplotype distribution were detected for whites and African Americans for preterm birth and SGA., In this cohort of young healthy Caucasian females, the T allele at position -509 of TGF beta-1 is associated with greater bone mass as measured by calcaneal ultrasound., TFG-beta is an inducer of gremlin expression in diabetic nephropathy., These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis., TGFbeta-1 is a major immunomodulatory component of poststorage leukocyte-depleted blood transfusions., Hypoxia-induced tumor cell tolerance to glucose starvation is caused by hypoxia-induced TGF-beta1 through AMP-activated protein kinase-alpha activation and the Akt/ARK5 system., An inverse relationship is shown for the first time in the ratio between ICAM1-expressing lymphocytes and transforming growth factor (TGF)-beta 1 serum concentrations during the clinical stages of acute rheumatic fever., TGF-beta1 enhances mineralization on implant materials of osteoblast cultures from elderly human subjects, results show that TGFbeta could induce tumoral progression in bladder carcinoma using a paracrine loop, confirming a role for the microenvironment, Transforming growth factor-beta1 (TGF-beta1) plays a critical role in promoting extracellular matrix (ECM) deposition and fibrosis., the signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant, May function as an effect modifier of APOE4 risk; plays a role in Alzheimer's disease pathogenesis, TGF-beta1 expression is related to tumor growth and metastasis in pancreatic adenocarcioma, TGF-beta1/bFGF and ET-1 have different roles in graft fibrosis in heart failure patients, TGF-beta and pro-inflammatory cytokines regulate MEL4B3, a novel mRNA induced in skin tumors, TGF-beta1 dose-dependently repressed Sftpb promoter activity in vitro, and a novel TGF-beta-responsive region in the Sftpb promoter was identified., Folic acid deficiency could result in reduction of TGF-beta1 protein levels and might contribute to formation of defects in the skull bone as observed in mengingocele patients, TGF-beta 1 is involved in the suppressive activity of Leishmania guyanensis-stimulated CD4+ CD25+ T cells from healthy controls, During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of transforming growth factor (TGF)-beta., TGF-beta-induced cell cycle arrest and migration, but not epithelial-mesenchymal transition, are abolished after silencing of Smad4., Significantly higher expression of TGFbeta1 and bFGF, although lower expression of core protein on the concave side, suggesting possible etiological factor or secondary change in development of adolescent idiopathic scoliosis., Association of endometriosis with TGF-B 1-509 gene polymorphism exists. T homozygote and T allele for TGF-B1 are associated with higher susceptibility to endometriosis., Up-regulated expression of TNC in nasal polyp tissues is related to eosinophil-derived TGF-beta1., Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts, TGFB1 regulates a wide variety of biological responses through transcriptional regulation of target genes. Disruption of ELF-1 results in the loss of the Smad4 activation and, therefore, a disruption of the TGF-beta pathway., Data show that leukotriene C4 stimulates airway epithelial cells through a p38 mitogen-activated protein kinase activation mechanism to produce transforming growth factor beta1, which results in fibroblast proliferation., Data show that endothelial cells express CD222 and CD87 in a membrane complex and demonstrate that the association of these two receptors is essential for the release of active TGF-beta., A C to T base change in TGFbeta1 SNP C-509T is associated with a higher risk of allergy., Angiogenesis in keloids is promoted by endogenous TGF-beta1 and VEGF., This study indicates an autocrine mechanism to maintain homeostasis in vivo for fibroblasts and other cell types, which produce TGF-beta1 to limit the fibrogenic response to TGF-beta1 and Bleomycin., This work presents in vivo and in vitro evidences of activation of TGF-beta1 expression by androgen and AR, and implicates the modulation of hepatocarcinogenesis by AR through the regulation of TGF-beta1 expression., Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis., TGF-beta signaling transduction in the kidney can be revealed by gene expression data mining., TGF-beta 1 may promote endometrial tissue repair through the inhibition of the proliferation, expansion, and migration of endometrial stromal cells, and through stimulation of contraction of the collagen gel matrix by these cells., The TGFbeta(1)-induced destabilisation of E-cadherin-mediated cell-cell adhesion involves phosphorylation of beta-catenin, which is regulated by E-cadherin adhesion complex-associated PI3-kinase and PTEN., The reciprocal modulating effects of FGF2 and TGFbeta1 on each other's receptors make the GM-490 cell line a new model for investigating the relationship between these growth factors and their receptors in autocrine loops., stimulates transcriptional activity of LTBP-3 promoter, PU.1 and Id2 modulate lineage options of langerhans cell precursors, downstream of TGF-beta1., TGFbeta stimulates transformation in the proepicardium., STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways, Distinct roles for Smad2 and Smad3 in TGFbeta1-induced CTGF expression and markers of EMT in human PTECs are reported., The release of TGF-beta1 in morbid obesity was primarily by the nonfat cells of human adipose tissue because release by adipocytes was less than 10% of that by the nonfat cells of adipose tissue., integrin-mediated TGFbeta activation is likely to play important roles in tumor growth and metastasis [review], Transforming growth factor-beta stimulates epithelial-mesenchymal transformation and smooth muscle differentiation of epicardial cells., Hyaline cartilage regeneration was studied using chondrocytes and TGFB1-producing chondrocytes., TGF-beta is involved in the physiological loss of gastric epithelial cells by activating apoptosis mediated by Smad7, Bim, and caspase-9, Increased glomerular expression of thrombospondin-1 (THBS1), transforming growth factor beta 1 (TGFB1), and connective tissue growth factor (CTGF), occurs from the earliest stage of diabetic nephropathy., role in persistent fungal pneumonia whereby it contributes to the local control of infection by enhancing macrophage antifungal efficacy through increased lysozyme secretion, A compartison of TGFB/Smad signaling was made between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions., Laminin-5 and TGF-beta1 cooperatively induce epithelial to mesenchymal transition in hepatocellular carcinoma, Review summarizes the role of TGF-beta as a potent ligand that regulates carcinoma, initiation, progression and metastasis through a broad and complex spectrum of interdependent interactions., Tenascin-C and TGF-beta1 were expressed in the majority of high-grade gliomas. Induction of Tenascin-C by TGF-beta1 may be a possibe mechanism for invasion of high-grade gliomas., Review of recent studies shows that insulin-like growth factor (IGF)-I signals cross-talk at multiple levels with various components of the TGF-beta signal pathway which, depending on context, may function either as tumor suppressor or as tumor promoter., Recent evidence in this review support a role for TGF-beta in the induction of tolerance and the control of autoimmune inflammation in the gut., TGF-beta1 in post-transurethral bladder tumor resection urine alters the expression of multiple genes in human transitional cell carcinoma in vitro, Decreased activity of TGFbeta in patients with acute coronary syndromes is at least partly due altered transcriptional activity of genes encoding TGFbeta., Review discusses genetic alterations and epigenetic modifications that occur in the different components of the TGF-beta superfamily signaling pathways in human tumors, and summarizes their correlation with clinical outcome., TGFbeta and interleukin-6 might play pivotal but opposing roles in the host tumor interaction, Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury., TGF-beta1 production and fibrosis require IL-13 signaling through the IL-13alpha2 receptor, involvement of TGFbeta1 through the Smad proteins in fibrotic diseases, signalling pathways induced by ET-1 and TGF-beta1 leading to augmented collagen I production by fibroblasts converge on a similar signalling pathway. Thereby, long-time stimulation by ET-1 resulted in a changed ET-receptor subtype ratio, Our correlative study suggests a role of TGF-beta-1 in early interstitial fibrotic changes in acutely rejected renal allografts, and we hypothesize that endothelin-1 and myofibroblasts pathways may play an important role in this process., transforming growth factor-beta1 overexpression and alteration in E-cadherin/beta-catenin complexes in bladder urothelium might play a crucial role in urinary bladder carcinogenesis in humans exposed to long-term low-dose ionizing radiation, TGFB1 possesses a highly polymorphic, extensive regulatory region that likely impacts the pathogenesis of numerous TGF-beta1 related diseases., The overall effects of TGF-beta1 in the kidney seem to be negative that increased expression of TGF-beta1 promotes interstitial fibrosis and vasculopathy associated with chronic allograft nephropathy., TGF-beta1 mRNA levels distinguish chronic allograft nephropathy patients from long-term transplant patients with stable renal function and varied levels of proteinuria., TGF-beta1 may function as a regulatory factor in fetal allograft survival during pregnancy., TGF-beta1 gene polymorphism may affect the disease progression in patients with myelodysplastic syndrome, TGF-beta1 acts on adjacent stromal cells to turn on Smad signalling that could lead to stromal decidualization., HCV NS5A modulates TGF-beta signaling through interaction with TbetaR-I, the PI3-K pathway negatively regulates TGF-beta/Smad signaling in neuroblastoma cells, These observations, together with the finding that CILP protein binds and inhibits TGF-beta1, suggest that CILP and TGF-beta1 may form a functional feedback loop that controls chondrocyte metabolism., TGF-beta1 increases in vitro airway wound repair via MMP-2 upregulation in respiratory epithelial wound repair., SRC-1 and GRIP-1, act as both corepressors of the glucocorticoid repression of PAI-1 gene transcription, and coactivators of TGFbeta-induced activation of the PAI-1 promoter., Enteric glial cell effects on Caco-2 cell density are significantly reduced by a neutralizing TGF-beta antibody., While high levels of TGF-beta appeared to be associated with protection against periportal fibrosis during chronic schistosomiasis mansoni, the strength of the association was low., Adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro., TGF-beta1 production was stimulated in Group A Streptococcus infected primary human tonsil fibroblasts., Administration of losartan, but not amlodipine, to hypertensive patients improves structural abnormalities and prevents the production of CTGF and TGF-beta in small arteries., GDF15exerts cardioprotective effects whereas TGF-ss1 does the opposite., positive (transforming growth factor beta1) and negative (cigarette smoking extract) regulators appear to influence the USF-E-box interaction and affect P4Halpha(I) expression, Elevated glucose concentrations increased TSP-1 synthesis, which was associated with reduced cell proliferation, increased TGF-beta1 bioactivity, and stimulation of FN synthesis, We propose that one of the mechanisms involved in TIMP-1 downregulation may be through TGF-signaling in chronic immune activation. These studies show a novel extracellular regulatory loop in astrocyte-TIMP-1 regulation., TGF-beta1 polymorphisms and their haplotypes is associated with adenocarcinoma and small cell carcinoma of the lung, TGF-beta is involved in neointimal formation in renal transplants during chronic rejection., Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C., TGF-beta1 signaling regulates IL-8 expression in prostate cancer cells and may contribute to the overexpression of IL-8 in human prostate cancer, new mode of cooperation between the TGF-beta and Wnt signaling pathways suggests a potentially important role for this distinct signaling pathway in the control of self-renewal and differentiation of a specific type of MSCs, Deviation in CD105/TGF-beta ligand complexes suggest that angiogenesis mediated by this complex is not a feature of pancreatitis., We conclude that cell matrix factors act cooperatively with cytokines to induce the expression of the components of the NADPH-oxidase in monocytic progenitor cells., The present review summarises the actual knowledge on the pathogenesis of hepatic fibrogenesis, the role of TGF-beta and its signalling pathways in promoting the fibrogenic response, and the therapeutic modalities., Our results suggest that TGF-beta signalling and subsequent expression of fibrogenesis related proteins in Dupuytren's disease is abrogated by NAC thus providing a basis for a therapeutic strategy in Dupuytren's disease and fibroproliferative disorders., The increase in the PDGF/TGF-beta ratio during uterine leiomyoma growth seems be important in tumour biology, In conclusion, EC death induced by high shear stress and VEGFR blockade leads to the production of factors, in particular TGF-beta1, that activate VSMC proliferation., studies demonstrate a novel role for IL-1alpha in mediating a proliferative response to TGF-beta signaling, analysis of inhibin and transforming growth factor beta-binding sites on betaglycan, tumor-derived TGFbeta-1 induces immunosuppression within sentinel lymph nodes (SLNs) before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes, c-Fos binding at the TGFbeta1 promoter proximal AP-1 site in human colon carcinoma cells is required for TGFbeta1 production by the tumor cells., PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit, In systemic lupus erythematosus, TGF-beta1 activation was linked with increased lymphocyte apoptosis, irreversible organ damage, and disease duration., TGF-beta1 decreased ADAMTS-1 mRNA and protein levels in decidual stromal cell cultures in a concentration- and time-dependent manner., upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in localized scleroderma fibroblasts, Our findings collectively suggest that non-classical secretion of Prx-I is induced by TGF-beta1, which is constitutively activated by furin in A549 cells., While a weak subepithelial proliferation occurs in stent-related stenoses, the dominant factor in late stages of untreated tracheal stenoses seems to be the high-level expression of TGF-beta1 and the deposition of extracellular matrix., Neutrophil derived elastase (NE) upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma., analysis of how the TGFbeta signal is disrupted in cancer [review], EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression, An association between the TGF-beta1 genetic profile and the development of PVR (proliferative vitreoretinopathy) was detected in this study., 'large' molecular weight molecules, the most important of which appears to be TGFbeta(1), make a significant contribution to immunosuppression by human seminal plasma, Gene expression alterations indicate a sophisticated regulation of counteracting tumor necrosis factor-alpha and transforming growth factor-beta cytokine expression in peripheral blood leukocytes after acute myocardial infarction, immunomodulatory pathways in the kidney are specifically dependent on TGF-beta(1), proliferation of Th1 clones are inhibited by TGF-beta1, whereas Th2 cells are not; the sensitivity of individual Th1 clones to TGF-beta1 is linked to the level of activation achieved in culture, Allele T at codon 10 (risk ratio, 6.7; P = 0.02) and an episode of acute rejection before protocol biopsy (risk ratio, 6.2; P = 0.01) were independent predictors of subclinical rejection., levels of TGFbeta-1 and TGFbeta R-2 were increased in the intimal matrices, smooth muscle cells, and macrophages, as well as in endothelial cells of atherosclerotic aorta, Expression is significantly associated with Peyronie's disease and may be a direct cause for its development., role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections, TGFbeta suppresses TERT by Smad3 interactions with c-Myc and the hTERT gene, TGF-beta1 plays a role in the progression of IgA nephropathy., Interleukin (IL)-13 and transforming growth factor-beta1 (TGF-beta(1)) are frequently coexpressed in these responses and are believed to play important roles in the pathogenesis of Th2-induced pathologies., CC homozygote may be at a higher risk of developing high myopia. Varied expression of this gene may contribute to the genetic predisposition to high myopia in Chinese Taiwanese., TGFbeta acts on hypoxia-inducible transcription factor-1alpha (HIF-1alpha) accumulation and activity by increasing HIF-1alpha protein stability, TGF-beta1 regulates COX-2 expression in human mesangial cells through the activation of ERK1/2, p38 MAPK, and PI3K, VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia, These findings suggest that the TGF-beta1 (+915C) polymorphic allele might be associated with chronic periodontitis in the Turkish population., a novel mutation was found to result in the inhibition of translocation of Smad3 protein to the nucleus and a reduction in the activity of Smad3 during TGF-beta-induced transcriptional activation, In summary, results suggest that an autocrine loop of TGF-beta confers resistance to apoptosis after an EMT process in hepatocytes, through the increase in the expression of EGFR ligands., overexpression of VEGF, its receptors flt-1, KDR/flk-1 and TGF-beta interaction may play an important role in the ovarian cancer biology, with potential effects on tumor growth and angiogenesis, These studies demonstrate that induction of fibulin 5 gene expression in lung fibroblasts is mediated via canonical TGF-beta/Smad signaling and requires the PI3-kinase/Akt pathway., in tumor cells becoming resistant to TGF-beta1-mediated growth inhibition, increased induction of the remaining TGF-beta1 pathways by interaction with other antiproliferative molecules, such as 4-hydroxynonenal, could help in inhibiting tumor growth, These results suggest that RACK1 modulates transcription of alpha2(I) collagen by TGF-beta1 through interference with Smad3 binding to the gene promoter., TGFbeta1 is significantly elevated in the cerebrospinal fluid in HIV-1 infected patients., These findings elucidate the function and complex regulation of integrin-mediated activation of TGF-beta within the epithelial-mesenchymal trophic unit (EMTU)., TGFB expression is not affected by hyperhomocysteinaemia either in normal or in high glucose in fibroblasts., These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia., TGF-beta1 mediates a physiologically relevant regulatory mechanism, selective for memory T cells present in the tumor microenvironment and nonmalignant chronic inflammatory tissues, TGF-beta1 overexpression is associated with advanced stage of esophageal adenocarcinoma and implies a negative impact on survival, High serum TGF-beta1 levels may be associated with an increased risk of death from pancreatic cancer., Transforming growth factor beta1 (TGF) seems to be an important stabilizing factor and prevents plaque rupture through the decrease of matrix metalloproteinases (MMPs)., The expression of TGF-beta1 and E-cadherin are correlated with lymph node metastasis in supraglottic larynx squamous cell carcinoma., Altered expression of several genes is responsible for disrupted TGF-beta signaling in ovarian cancer and may be useful as new and novel therapeutic targets for ovarian cancer., increased toxic interactions by TGF-beta1 plus CYP2E1 can occur by a mechanism involving increased production of intracellular ROS and depletion of GSH, resulting in mitochondrial membrane damage and loss of membrane potential, followed by apoptosis, This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production, TGFB1 T+869C gene polymorphism is involved in the susceptibility to duodenal ulcer., Synthesis of TGFbeta-1 and type I TGFbeta-receptor increases over time in recipients developing chronic allograft nephropathy., analysis of the mechanism through which results showed that Human Papillomavirus-16 E6 and E7 increased TGF-beta1 promoter activity in cervical tumor cells, supernatants from HPV-transformed cell cultures contained IL-10 and TGF- beta1., NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling, Korean subjects carrying the Leu/Leu and Pro10Leu sequence variants in and around the promoter and exons of TGFB1 are susceptible to both ischemic stroke and vascular dementia., The mRNA expressions of TGFbeta1 in hMSCs increased with the length of cell culture., In proximal tubular epithelial cells, TGF-beta1 autoinduction requires the coordinated action of independently regulated Smad and non-Smad pathways., Study demonstrates elevated TGF-beta1 levels in women with prior history of gestational diabetes mellitus., TGF-beta1 may play a role in the tissue remodeling processes in allergic rhinitis., TGF-beta1 induced morphologic and molecular expression changes suggestive of epithelial-to-mesenchymal transition in a Barrett's adenocarcinoma cell line. These were reversible by BMP7., TGF-beta "cross-links" the HER2/Vav2/Rac1/Pak1/actin/actinin complex at cell lamellipodia, prolonging Rac1 activation and increasing cell survival and metastasis., aberration of the TGF-beta pathway promotes carcinogenesis of oral squamous cell carcinoma, MCP-1 functions as a chemoattractant to stimulate migration of VSMCs and mesenchymal cells toward ECs, signaling is enhanced by dephosphorylation of linker regions of Smad2 and Smad3, The fibrotic action exerted by TGF-beta1 in the lung is mediated by MAPK activation and by an increased synthesis of the profibrogenic cytokines IL-6 and IL-11; all these effects are prevented by corticosteroids via inhibition of MAPK phosphorylation., In cystic fibrosis, both extremes, highest or lowest TGF-beta 1 production, were associated with impaired lung function, TGF-beta1 stimulates the Gene expression profiles of LX-2 cells in the presence and the absence of rhDecorin., TGF-beta1 activates IL-6 production, and the functional interaction between TGF-beta1 and IL-6 contributes to intrahepatic cholan-giocarcinoma (ICC) cell growth by TGF-beta1., Results reveal potential new signaling pathways and several new genes affected by TGFbeta in epithelial cell differentiation., SHP is a novel co-regulator of Smad3 that regulates TGF-beta signaling, uterine natural killer cell responses to microbial pathogens in the endometrium are regulated by the amount of biologically active TGF-beta present within the human endometrium, TGFbeta1 inhibited the appearance of cell death-inducing DFF-like effector A (CIDE-A) in 2-D gels with Helix pomatia agglutinin-precipitated proteins, cross-talk between TGF-beta1 and Vascular Endothelial Growth Factor(VEGF) signaling converts VEGF/flk-1-activated p38(MAPK) into a proapoptotic signal, Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients., Variants in genes for TGF-beta1 (Leu10>Pro and Arg25>Pro)are not associated with low BMD in postmenopausal Czech Caucasian females., These results suggest a central role for KLF11 in TGFbeta-induced c-myc repression and antiproliferation., This review emphasizes the unique ability of TGF-beta to direct CD4+ T-cell lineage commitment to both proinflammatory T helper 17 (Th17) cells and anti-inflammatory T regulatory cells., This preliminary study is the first to suggest that the TGF-beta1 signal sequence (29T-->C) and IL-6 promoter (-597G-->A)|(-572G-->C) transitions are predictive for the time to onset of aseptic instability after total hip arthroplasty, different patterns of infiltration in desmoid and fibroma tumours are due to changes in extracellular matrix (ECM) components and cell-ECM interactions which can be ascribed to altered TGFbeta(1) mRNA expression and TGFbeta(1) activity, mutations of the amino-acid residues, D55 and E142 of TbetaR-II, resulted in loss of TGF-beta binding and downstream signaling activity, TGFbeta expression is induced by rhinovirus infection in respiratory epithelial cells, The mRNA levels of TGF-beta1 were significantly produced by the megakaryocytes may be associated with the etiology of bone marrow fibrosis in AMM., Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation., The variant alleles of the promoter polymorphisms, TGFB1 C-509T and TGFBR2 G-875A, were associated with a significantly decreased risk of gastric cancer., An inhibition of brain pericyte-derived TGF-beta1 contributes to the occurrence of CsA-induced dysfunction of the blood-brain barrier., These results also indicate that the CSF level assay of TGF-beta1, TbetaR-II and LRG is useful for the diagnosis of patients with INPH, and TGF-beta1, TbetaR-II and LRG may be involved in the pathogenesis of the disease., We found a highly significant association between TGF-beta polymorphisms and calcineurin inhibitors induced end-stage renal failure after heart transplantation., Epac1 inhibits TGFbeta-dependent regulation of cell migration and adhesion through TbetaRI, Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis., TGF-beta1 (codon 25) single-nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied., Disruption of the TGF-beta 1-Smad signaling pathway may lead to the resistance of TGF-beta 1 growth-inhibitory effect on oral squamous cell carcinoma., The expression of collagen type II and TGF-beta1, bFGF in adolescent idiopathic scoliosis was similar to congenital scoliosis., calcineurin-induced reduction of Treg or TGF-beta expression predisposes nontransplanted tissue to inflammation, but indicate that combined immunosuppression hampers Treg development in the intestine., findings show that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-beta-activated Smads; this mechanism promotes TGF-beta cytostasis in human cells, fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype, These results suggest that the +869C allele, responsible for a Leu-->Pro substitution in the signal peptide sequence of the TGF-beta1 protein, may have a predisposing role in the development of colorectal cancer., These results suggest that TGFbeta Smad3-dependent signalling is perturbed in Barrett's carcinogenesis, resulting in failure of growth-arrest., TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation., Both vitreous and TGF-beta signals increased HO-1 expression in retinal pigment epithelial cells via reactive oxygen species., Our study suggests a role of transforming growth factor beta-1 in interstitial fibrotic changes in renal AA and AL amyloidosis., results provide evidence that, at low concentrations, TGF-beta-1 promotes matrix metalloproteinase dependent branching tubulogenesis by mammary epithelial cells in vitro, and suggest that it plays a similar role during mammary gland development in vivo, TGF-beta signaling regulates gut epithelial gene expression by targeting GATA4., High TGFbeta is associated with glioma, up-regulates nerve growth factor in human dental pulp cells, The results indicate that Langerhans cells depend on soluble factors for the maintenance of the differentiated state within epidermis and that TGF-beta1 is a major one of such factors, the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity, common variants in TGFB1 gene do not strongly influence genetic susceptibility to diabetic nephropathy in an Irish Caucasian population, TGF-beta1, together with Notch signaling, functions to arrest epithelial growth., PDK1 negatively regulates TGF-beta-mediated signaling in a PDK1 kinase-dependent manner via a direct physical interaction with Smad proteins, and Smad proteins can act as potential positive regulators of PDK1, Transforming growth factor-beta1 may be a factor in inducing the expression of c-fms in cervical cancer cells., This largest study to date of genetic variation in TGFB1 and asthma and atopy adds to increasing evidence for a role in these disorders., The polymorphism of TGF-beta1 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage., No correlation between disease activity and increased salivary TGF-beta 1 concentration is shown in twenty-eight patients with confirmed diagnosis of Crohn's disease., Persons with osteoporosis have an increased oxidative stress that is not accompanied by changes in TGF-beta 1 levels., Early and sustained increases in matrix stiffness occurred in response to rhTGF-ss1, which could be increased by IL-1beta. It stimulated expression of alpha-SMA, collagens I & III, and CTGF., These data suggest that EGF may be an attractive alternative to TGF-beta1 for engineering fibrin-based connective tissue substitutes with adequate strength and minimal tissue contractility., These results suggest that TGFbeta1-induced FN production in HKC cells is p38 MAP kinase dependent and Smad independent. Targeting p38 MAP kinase may be of therapeutic value in renal fibrosis., The positive expression of TGF-beta1mRNA was 78.75% (33 cases), and was positive correlative to the bone metastasis, TNM stages, MVD in prostate cancer., These data suggest autocrine TGF-beta1 antagonizes BMP signaling through modulation of inducible Smad6 and the activity of BMP specific Smad1/5., analysis of cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways, TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells., TGF-beta1 modified ADP-induced tyrosine phosphorylationof 64-, 80- & 125-kDa proteins depending on incubation time. The modulating effect of TGF-beta1 on platelet aggregation may play a role in pathological states and vascular injury., No association could be found between transforming growth factor-beta1-509 (C/T) promoter gene polymorphism and patients with ulcerative colitis., TGF-beta1 polymorphisms, and their haplotypes are significantly associated with nasopharyngeal carcinoma, Data showed that the frequency of the TGFbeta (G codon 25) allele is 1.00 and no TGFbeta (C codon 25) allele is found., Nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote TGF-beta1-induced proliferation and hypertrophy of human airway smooth muscle, Surface expression of TGF-beta on DCs in association with LAP is one of the mechanisms by which immature DCs limit T cell activation and thus prevent autoimmune responses., TGF-beta (-509)CC genotype may be a protective factor for pneumoconiosis. TGF-beta (+915)GC genotype may be a susceptible factor for pneumoconiosis., findings indicate the Leu10Pro & C-509T polymorphisms may be involved in modulation of expression of TGF-beta1; predisposition to peptic ulcer disease could be linked to particular alleles of this gene, Suppression of hepatitis C virus-specific interferon-gamma-producing peripheral T cells seemed to be primarily mediated by TGF-beta 1, in the setting of HIV coinfection., Real-Time-PCR showed that TGFbeta1 expression is auto-inductive, whereas FGF2 is auto-repressive. FGF2 also induced TGFbeta1 secretion in the absence of increased TGFbeta1 mRNA expression., autocrine TGFbeta signaling can enhance the survival of MCF-7 cells by maintaining the level of active Erk high and the level of active p38 low., WNK1 is a dual modulator of TGFbeta-Smad signaling pathways, The aim of the study was to determine the pattern of immunohistochemical expression of transforming growth factor beta1 (TGFbeta1), metalloproteinase 9 (MMP-9), and Ki-67 in colorectal cancer and adenomatous polyps., Sequence variants of the TGF-beta1 gene were not associated significantly with high myopia., Although ulcerative colitis patients have abnormal amounts of salivary TGF-beta1 and nitric oxide, their disease activity cannot be predicted by these factors, which may indicate their pathophysiologic roles., The aim of this study was to examine the role of TGFbeta in an in vitro model of islet morphogenetic plasticity, transforming growth factor 1beta1-stimulated JC virus multiplication is blocked by MEK1/2 inhibitors, Implication of anticancer therapy-induced TGF-beta as a pro-metastatic signal in tumor cells provides a rationale for the simultaneous use of these therapies in combination with TGF-beta inhibitors., High-producing genotype of TGF-beta may be beneficial and may play a potential role in the resolution of renal inflammation., Interactions of downstream signaling induced by IL-13 in concert with transforming growth factor (TGF)-beta 1 increase Smad activation to regulate tissue inhibitor of metalloproteinase (TIMP)-1 expression in primary airway fibroblasts., we demonstrated that TGFbeta-1 enhanced cytotoxic (proapoptotic) action of doxorubicin towards cultured human lung carcinoma A549 cells., High expression of TGF-beta1 in inflammatory mucosa compared with the low expression in polyps may reflect an important role in the inhibitory mechanisms of nasal polyposis., A novel mutation of TGFB1 in a Chinese family with Camurati-Engelmann disease is reported., SMAD7 antagonizes TGFB1 signaling in the nucleus by interfering with functional Smad-DNA complex formation., TGFbeta1 and TIMP-1 are involved in the course of developing hepatic fibrosis and TIMP-1 may be regulated by TGFbeta1., data suggest that TGFbeta has a direct inhibitory effect on G2 checkpoint kinases, which is regulated at mRNA level, TGF-beta1 may act in an autocrine fashion to induce airway smooth muscle hyperplasia, mediated by its receptor and several kinases including PI3K, ERK, and JNK, whereas p38 MAPK is a negative regulator., These results indicate that impaired competition with p300 is the possible cause of dysfunction of c-Ski/SnoN in scleroderma fibroblasts and that this might contribute to maintenance of the autocrine TGFbeta loop in this disease., The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis., The TGFB/SMAD3 signaling pathway is involved in butyrate-mediated vitamin D receptor expression., S100C/A11-mediated pathway is at least partly involved in conferring upon human squamous cell cancers resistant to TGFbeta-induced growth suppression, TGF-beta 1 and cardiotrophin-1 exert differential effects on myofibroblast proliferation and contraction in vitro. A balance of these effects may be important for normal cardiac wound healing., TGF-beta1 has a role as both a disease marker and a therapeutical target for cardiovascular disease [review], negative effect of EBNA1 on the expression of TGFbeta1-responsive betaig-h3 and PAI-1 genes was confirmed at the protein level in EBV-infected carcinoma cells, Substance P modulates fibroblast-mediated epithelial cell restitution in vitro via a TGFB1 dependent mechanism, TGF-beta 1 exhibits an acute pro-oxidant effect in cartilage that is not cytotoxic, suggesting a role in physiological cell signalling, The type of cartilaginous tissue formed under the influence of TGFbeta1 differed in terms of both cell phenotype and gene expression profiles from BMP-2 and -7, endoglin and beta-arrestin2 interact and have roles in regulating transforming growth factor-beta-mediated ERK activation and migration in endothelial cells, Most chronic allograft nephropathy patients have high TGF-beta1 production genotype, which might be a risk factor for CAN after renal transplantation., study found no evidence of association of prostate cancer with five TGFB1 genetic polymorphisms and their haplotypic combinations in the Prostate, Lung, Colorectal, and Ovarian Trial (PLCO), TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level., PGE(2) has the potential to limit TGF-beta1-induced myofibroblast differentiation via adhesion-dependent, but Smad-independent, pathways, TGF-beta(1) gene polymorphism in codon 10 and 25 is not associated with susceptibility to psoriasis vulgaris, but may be important for the type of the disease., Genetic variants of TGFB1 and TGFBR2 genes may contribute to the risk of developing gastric cancer., The molecular regulation of heme oxygenase-1 by transforming growth factor-beta1 in human renal proximal tubular cells is reported., study shows that the TGFB1-509C>T polymorphism might not be associated with POAG, Treatment with lactate was accompanied by enhanced mRNA expression and release of TGF-beta1, which also shows anti-angiogenic activity in the model., prostate cancer cells have a role in altering endoglin expression and attenuating transforming growth factor-beta signaling in reactive bone marrow stromal cells, These results suggest that T869C polymorphism of the TGFbeta1 gene is involved in the development of autoantibodies and the occurrence of aseptic necrosis in patients with SLE., TGF-beta1 may play a dual role in HBV infection, in the suppression of immune responses against viral infection and in the direct inhibition of viral replication, resulting in minimization of liver damage in patients with chronic hepatitis., ECP stimulates TGF-beta(1)-release by human lung fibroblasts, suggesting a potential mechanism for eosinophils in the fibrotic response., TGF-beta1 influences the susceptibility for otosclerosis, and that the I263 variant is protective against the disease., transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis., The growth factor TGF-beta1a was upregulated in RA synovial fibroblasts, Chronic inflammation associated with hepatitis C virus infection shifts hepatocytic TGF-beta signaling from tumor-suppression to fibrogenesis, accelerating liver fibrosis and increasing risk for hepatocarcinoma., VEGF-A/TGF-beta1 polymorphisms could be genetic markers of the process of urinary tract infection and vesicoureteral reflux., TGF-beta1 may play a role in the pathogenesis of idiopathic male osteoporosis, TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors., Results describe a contact-dependent mechanism by which mesenchymal stem cells modulate IL-10 and TGF-beta gene expression in T cells., Variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma., Adam12 contributes to Tgfb signaling through interaction with the type II receptor., TGF-beta1 can be released from targeted T98G cells and plays a key role as a signaling factor in the radiation induced bystander effect by further inducing free radicals and DNA damage in the nontargeted bystander cells., Inhibition of beta-catenin resulted in increased TGF-beta1-dependent Smad3 phosphorylation and restoration of TGF-beta1 anti-proliferative effects., failure to find any significant association between leukocyte telomere length and 10 single nucleotide polymorphisms in two ageing-related candidate genes, TGFB1 and KLOTHO, MMP-1 produced from melanoma cells may play a role in tumor progression by both degrading matrix proteins and generating active growth factors such as TGF-beta in vivo, No significant SNP or haplotypic associations were observed for TGFbeta1 or hepatocyte growth factor in autism, The content of TGF-beta1 and IL-1beta decreased after the femoral neck injury. In case of TGF-beta1 the difference was statistically significant (p<0.05)., TGF-beta(1) and mechanical stress induce xylosyltransferase I expression in cardiac fibroblasts and have impact for ECM remodeling in the dilated heart., TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and is mediated in part through a TbetaRII/Smad3-dependent upregulation of FGF-2 expression and release., data suggest that ligand release-independent transactivation of EGFR may diversify early TGF-beta signaling and represent a novel pathway leading to TGF-beta-mediated gene expression., transforming growth factor-beta has a role in Smad3-dependent activation of Gli2 and Gli1 expression, TGF-beta reduces interferon-gamma-induced major histocompatibility complex (MHC) class II expression in mesenchymal stromal cells via serum factor and cell density effects on transactivator CIITA expression., An association between the -509C/T polymorphism of the TGF-beta 1 gene and an increased risk of deep infiltrating endometriosis., The mRNA expression of TGF-beta1 in keloid was higher than that in hyperplasic scars and normal skin., Our findings suggest that women who experience eclampsia/pre-eclampsia with severe maternal and/or fetal complications are more likely to have a genetic predisposition to produce high levels of TGF-beta 1 as defined by polymorphisms at codon 10., These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients., Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by TGFB1., TGF-beta and TC21 have roles in tumorigenesis, a novel role for the plasminogen activation system in the regulation of fibroblast apoptosis and a potential role of TGF-beta1/PAI-1 in promoting (myo)fibroblast survival in chronic fibrotic disorders., Higher levels of total TGF-beta1 in tumour tissue at surgery may be indicative of distant metastases, and low levels of active TGF-beta1 in plasma may indicate a risk of developing secondary metastases., Smad7 overexpression in cultured hepatocytes abrogated TGF-beta-dependent and intrinsic CTGF expression., hTERT and extremely low concentrations of TGF-beta1 (2 pg/mL) synergistically activate ERK 1/2 in fibroblasts by a mechanism that is independent of the autocrine TGF-beta1 lo, Our data allow us to consider TGF-beta1 and alpha-SMA as key molecules related to placental villous tree phenotypic changes responsible for increased impedance to blood flow observable in fetal growth restriction pre-eclamptic placentae., the role of TGF beta 1 in high glucose-induced MIP-3 alpha expression, The overexpression of TGF-beta 1 and TGF-beta 1 mRNA could be useful markers for early diagnosis and predicting prognosis of HCC., autocrine production of TGF-beta1 upregulates the expression of Hic-5, which is essential for perpetuating the decreased proliferation seen in pathogenic myofibroblast, Children with transforming growth factor, beta 1 (TGF-beta1) -509TT genotype are at higher risk of asthma occurrence if they live near a freeway or were exposed to tobacco smoke in utero., that genetic variants in transforming growth factor beta 1 may modulate the risk of esophageal squamous cell carcinoma., The renal injury of CC genotype in TGF-beta1 is more serious than that of TC genotype and of TT genotype. The serum level of TGF-beta 1 can indicate the severity of the renal injury and the protective effect on kidney with valsartan., Unlike postnatal fibroblasts, fetal fibroblasts phosphorylated extracellular signal-regulated kinases in response to TGF-beta1. These altered responses may contribute to the transition between regeneration and scar formation seen during development., TGFB1 genotypes are associated with erectile dysfunction and late rectal bleeding in radiotherapy for prostate cancer. Identifying these genotypes may predict which men are likely to suffer from poor quality of life after radiotherapy for prostate cancer., Data suggest that polymorphonuclear leukocytes decrease dendritic cell allostimulatory ability via production of elastase leading to a switch of immature DCs into TGF-beta1-secreting cells., lower TGF-beta1 expression is associated with colon carcinoma, Snail1 is involved in renal tubular EMT and TGF-beta1 regulates Snail1 at the transcription and protein degradation levels, Polymorphisms in two key anti-inflammatory cytokines, IL-10 and TGF-beta, are associated with susceptibility to EBV-associated posttransplant lymphoproliferative disorder., In this review, transforming growth factor (TGF)-beta is a key cytokine that initiates and terminates tissue repair associated with peritoneal membrane failure during chronic peritoneal dialysis., Individuals with the transforming growth factor-beta1 -509CC and 869TT genotype may have increased susceptibility to vesicoureteral reflux, The TNFalpha-308A/TGFbeta1 25C genotype may be one component of genetic susceptibility to SLE in Colombian population., hTERT appears to be efficiently regulated by EPO and TGFbeta in an opposite way in erythropoietic cells, arguing for a role of telomerase in red blood cell production, The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF., EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor, Over one fourth of women with cervical insufficiency have a family history of cervical insufficiency and the COL1A1 intron 1SP1 and TGF-beta Arg-25-Pro polymorphisms are associated with the condition., TGF-beta1-induced Sporothrix schenckii adhesion to endothelial monolayers results from the increased exposure of the subendothelial extracellular matrix and this event may contribute to transendothelial migration., R124C and R555W TGFBI mutations cause lattice and granular type I corneal dystrophies in the studied families., The -509C and codon 10T haplotypes are significantly associated with disease severity indicators in both chronic beryllium disease and sarcoidosis., The expression of TGF-beta1 was reduced in carcinoma tissues compared with para-carcinoma tissues., Raloxifene treatment reduces bone turnover markers, parathyroid hormone and induces vitamin D in postmenopausal women. Serum levels of IL-6 and TGF-beta1 in the patient group after treatment, decreased to levels lower than those in the control group., Polymorphisms in the promoter of TGFB1 are not associated with large increases in breast cancer risk overall among Caucasian women.Alleles associated with increased TGFB1 levels may reduce the risk of estrogen receptorpositive breast tumors., Long-term increases of transgenic TGF-beta 1 play a role in modulating cerebrovascular tone by dampening endothelin-1-mediated activation of the p38 MAP kinase/heat shock protein-27 signaling pathway., TGF-beta(1) might be considered as a predictor of pleural thickening in pleural tuberculosis.There is a correlation between pleural fluid TGF-beta(1) levels before treatment and the degree of pleural thickening., Mutant p53 attenuates TGF-beta1 signaling. This was exhibited by a reduction in SMAD2/3 phosphorylation and an inhibition of both the formation of SMAD2/SMAD4 complexes and the translocation of SMAD4 to the cell nucleus., Gastrointestinal carcinoid tumor fibrosis is a CTGF/TGFbeta1-mediated stellate cell-driven fibrotic response., TGF-beta may modulate the expression of chloride channel protein CLC-2 and CLC-3 in chronic rhinosinusitis without nasal polyps., PCAF-dependent acetylation of lysine 380 abrogates repressor function of Fli1 with respect to collagen expression; TGFb-dependent acetylation of Fli1 may represent the principal mechanism for TGFb-induced dissociation of Fli1 from the collagen promoter, Conversion from calcineurin inhibitors to sirolimus treratment in heart allograft dysfunction presented a significant decrease in TGF-beta urine levels. representing a decreas in allograft dysfunction., These results suggest that TGF-beta1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD., Review is an impartial and exhaustive compilation of reported papers regarding the contemporary debate over expression of TGFbeta1 in asthmatics and its essential role in airway remodeling., altered transforming growth factor-beta signaling contributes to tumor progression and metastasis as well as development of fibrosis [review], TGF-beta1 promoter gene single nucleotide polymorphisms are not associated with disease susceptibility or progression in Japanese patients with primary biliary cirrhosis, These data reveal a novel function for CTGF in the regulation of epithelial tissue repair beyond its established role in fibrosis, and further highlight the complexity of TGFbeta regulation of epithelial cell function., a novel tumorigenic role of Id-1 through reorganization of actin cytoskeleton and disassembly of cell-cell adhesion in response to TGF-beta1 in human prostate epithelial cells, TGFbeta1 represses CYP7A1 gene transcription in human hepatocytes by a mechanism involving Smad3-dependent inhibition of HNF4alpha and histone deacetylase remodeling of CYP7A1 chromatin., the TGF-beta-inducing protein of H. pylori might mediate the immune response and contribute to the pathogenesis of H. pylori infection, These findings indicated that both the NF-kappaB and IRF-1 sites are required for the repression of promoter activity of IL-12 p40 by TGF-beta., Autocrine TGF-beta1 exists in NPC patients, which is correlated to the local relapse and survival., the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta., TGFbeta1 acts directly epidermal Langerhans cells through an autocrine/paracrine loop, and it is required for cell development and/or survival., local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis, In primary human tubular epithelial cells (HUTEC) under TGF beta 1 stimulus, 977 genes were found differentially expressed., production of TGF-beta1 within the BM microenvironment of chronic idiopathic neutropenia patients results in downregulation of IL-10 and reduction of myeloid progenitor cells, Cyclic stretch thus increases the abundance of CD40 in endothelial cells through transforming growth factor-beta1/Alk-1 signaling, immune regulation of TGF-beta1 by CD4+CD25+ regulatory T cells may play a fundamental role in the pathogenesis of childhood immune thrombocytopenic purpura, Transforming growth factor-beta has a role in the immune response to malignant disease [review], Gremlin induces lung fibrosis in the mouse and human lung via decreased BMP-signaling and increased transforming growth factor-beta signaling. This effect can be inhibited by BMP-7 administration to the mouse, Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of tumor cells, Serum TGF-beta1 concentration is not a potential biomarker for AD, and TGF-beta1 genetic variants (-800, -509, and +869) are not risk factors for AD., conclusion of this study is that TGF[beta] bioactivation in cholesteatoma epithelium is not augmented but still correlates to survival and migration; in the stroma, TGF[beta]; bioactivation leads to excessive extracellular matrix deposition, This study shows for the first time that TGF-beta1 gene 869 T/C polymorphism may contribute to a genetic risk factor for esophageal squamous cell carcinoma in a Chinese population., The phenotypes of Thiel-Behnke corneal dystrophy are closely correlated with TGFBI mutation., Participation of BRG1 in TGFbeta action suggests a widespread yet differential involvement of BRG1 SWI/SNF remodeler in the transcriptional response of many genes to this cytokine., Data suggest a possible role of TGF-beta/Smad signalling in the pathogenesis of basal cell carcinoma., TGF-beta1 codon 10 C allele plays a role in the development of EBV-related diseases, increased expression of TGF-beta1 mRNA by Leukotriene D4 also occured in A549 and normal human bronchial epithelial cells via a Cysteinyl-leukotriene receptor 1-dependent mechanism, In addition to increased serum TGF-beta1 levels, the T allele of the C-509T polymorphism is related to increased airflow obstruction but attenuated eosinophilic inflammation, hMo-DC differentiated in the presence of physiologically relevant concentrations of TGFbeta1 (2 ng/ml) failed to undergo complete maturation despite adequate stimulation with LPS or LPS+IFNgamma., The early induction of TGF-beta1 at the point of SCI suggests a role in the acute inflammatory response and formation of the glial scar, while the later induction of TGF-beta2 may indicate a role in the maintenance of the scar., SARS coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling, Single Nucleotide Polymorphisms in transforming growth factor beta 1 and p53 is associated with breast cancer., The C allele of the Leu10Pro polymorphism of TGFB1 may predispose men to a more rapid prostatic cancer progression., The down-regulation of TGF-beta1 expression and its target molecules in insulinomas is a new aspect of this cytokine., Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae., These results suggest that Dab2 is a ligand dependent bi-directional regulator of ERK1,2 activity., High levels of TGF-beta-1 are associated with worse survival independent of stage of breast cancer, Signaling competent membrane-bound TGFbeta on cancer cells is thus likely to be a key player in regulating tumor cell interactions with each other as well as with other cells in their microenvironment., TGF-beta 1 is closely related to differentiation of enamel organ and initiation of matrix secretion, OPN is required for the differentiation and activity of myofibroblasts formed in response to the profibrotic cytokine transforming growth factor-beta1., TGF-beta 1 first appeared during canalisation stage in the surrounding mesenchyme and, in the more differentiated stages, was expressed in the cytoplasm of acinar cells throughout the adult gland., Polymorphisms associated with increased expression in the cytokines TNFalpha and TGFbeta1 are overrepresented in the Myelodysplastic syndromes (MDS) population., single nucleotide polymorphisms of TGFB1 at C-509T demonstrates a protective effect against high grade prostate cancer and cases with poor prognosis, These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins., PPARgamma plays a negative role by directly acting on Smad and ERK phosphorylation in human endometrial cellt reated with TGF-beta1., the ratio of HGF/TGF-beta1 may play a role in transient nephromegaly in children with Kawasaki disease, The aim of this study was to analyse the profile of TGF-beta1 and the expression of its receptor (TbetaR I, TbetaR II and TbetaR III-betaglycan) genes in IPAH and in secondary forms of pulmonary arterial hypertension [Eisenmenger's syndrome patients]., The TGFbeta immunopositivity correlated with sclerotic/fibrotic lesions (interstitial fibrosis, tubular atrophies, vascular hyalinosis/fibrosis, chronicity index), and negatively with glomerular filtration rate., studies suggest that IL-1beta, BK, and TGF-beta1 impair IP receptor-mediated cAMP accumulation by multiple effects on different components of the signaling pathway and that these effects are PKA and p38 MAP kinase dependent., Integration of TGFB and RAS signaling silences RABGEF1 and enhances growth factor-directed cell migration., TGF-beta regulates androgen receptor-dependent gene expression in prostate cancer cells., TGF-beta(1) regulates proliferation through Smad3 signaling in both fibroblast populations; however, it is the levels of HA generated by the cells that influence the outcome of this response., TGF-beta1 secretion, TGF-beta-mediated transcriptional response, expression of activin receptor-like kinase (ALK) 5 protein and phosphorylation of Smad 3 were also enhanced by treatment with N-Shh, there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with ulcerative colitis and normal subjects, the +869T/C polymorphism in the TGF-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease., TGF-beta1 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of chondrosarcoma cells, possible link between TGF-betal gene polymorphisms and the characteristics of peritoneal transport and longitudinal change of peritoneal transport characteristics in CAPD, KSHV evades both the antiproliferative effects of TGF-beta signaling by silencing TbetaRII gene expression and immune recognition by suppressing TGF-beta-responsive immune cells through the elevated secretion of TGF-beta1, TGF-beta1, TbetaRI, and TbetaRII loss of expression correlates with differentiation in human oral squamous cell carcinomas, These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium., Downregulation of E6 and E7 levels by IL-4 in CaSki cells is weaker than that exerted by TGF-beta1, a known LCR inhibitor., Results describe TGF-beta binding in human Wharton's jelly., mice overexpressing human latent TGF-beta1 in the skin were protected against anti-glomerular basement membrane crescentic glomerulonephritis, Impaired synthesis of TGF-beta1 by mononuclear cells seems to be present in patients with chronic forms of Lyme borreliosis when compared to those with early stage of the disease, Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways., Together, these findings show that TGFbeta superfamily activation of Smad2/3 is required for repression of spontaneous differentiation under strain., TGF-beta1 increases integrin alpha5beta1 expression through the extracellular signal-regulated kinase (ERK) signaling pathway in human airway smooth muscle cells from asthmatic and nonasthmatic subjects., tagln is a novel target of TGF-beta/Smad3-dependent gene expression in alveolar epithelial type II cells, AMPK inhibits TGFbeta-induced transcription downstream of Smad3 COOH-terminal phosphorylation and nuclear translocation, DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein in cultured leukocytes., An association was found between 25Pro allele and 25ArgPro genotype with low risk of essential hypertension in male individuals., TGF-beta1 and CTGF mRNAs are correlated with urinary protein level in IgA nephropathy., The role of multinucleated giant cells may thus be different from epithelioid cells by virtue of higher MPT64, more TGF-beta, and reduced caspase 3 which may contribute towards persistence of infection., TGF-beta produced by adjacent regulatory T cells interferes with polarization of T helper cells secretory machinery toward antigen-presenting cells, TGF-beta1/TNF-alpha levels and endothelial cell activation are interrelated in kidney transplant patients., Polymorphic variation in the TGFB1 gene does not play a major role in regulating BMD or susceptibility to fractures. A weak association was found between C-1348-T and lumbar spine BMD in men, and between C788-T and risk of incident vertebral fractures., TGFbeta1 stimulates CCN2 expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism, evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function., Our data suggest that p107 and p130, but not pRb, and the repressor E2F, but not activator E2Fs, play a critical role in regulating E2F-responsive gene expression., Chondroitin sulphate and its derived hydrolytic fragments (CSf) repress COL1A1 gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 transcription factors., TGF-beta1-mediates downregulation of TbetaRIII mRNA expression through effects on the ALK5/Smad2/3 pathway., PP2A functions as a negative regulator in TGF-beta1-induced TAK1 activation, Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy., Glomerular TGF-beta1 may induce tubular expression of C5b-9. Increased tubular C5b-9 expression may result in interstitial fibrosis through increased TGF-beta1 production., the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease., TGF-beta1-induced HaCaT cell migration is mediated by MMP-14, which regulates MMP-9 expression via JNK signaling, loss of Smad4 contributes to aberrant RON expression and cross-talk of Smad4-independent TGF-beta signaling and the RON pathway promotes an invasive phenotype, the first study reporting on a possible role of TGFbeta1 common haplotypes in the onset of AMI in young patients, FLIP levels decline with TGFbeta1 treatment, suggesting that apoptosis is mediated by caspase-8 and indeed the caspase inhibitor crmA blocks TGFbeta1-induced apoptosis., TGF-beta(1) upregulation of aldose reductase involves transcription factor AP-1., TGFBR1*6A may contribute to cancer progression through RhoA activation in a TGF-beta signaling-independent manner, VE-cadherin promotes breast cancer progression via transforming growth factor beta signaling, transforming growth factor-beta1 plasma levels with kidney allograft rejection, analysis of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis, HIV increases HCV replication through a TGF-beta1 dependent pathway., this signaling pathway was dysregulated in patients with tropical spastic paraparesis, The miR-106b-25 cluster, including miR-106b, miR-93, and miR-25, is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer., identified activin-mediated transforming growth factor (TGF)-beta signaling, platelet-derived growth factor (PDGF) signaling and fibroblast growth factor (FGF) signaling as the key pathways involved in MSC differentiation, Ginsenoside and berberine could promote the secretion of TGF-beta1 in PG cells, but could not change the level of PGE(2)., expression of glomerular TGF-beta1 and alpha-SMA, and interstitial TGF-beta1 is not correlated with clinical course in IgA nephropathy, These results demonstrate that TGF-beta abrogates prolactin-stimulated beta-casein gene expression in mammary epithelial cells through, at least in part, a Smad3-dependent mechanism., Data show that TGFbeta1 codon 25 genotypes Arg/Pro or Pro/Pro are not associated with alcoholic liver cirrhosis., dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function, gene polymorphisms in TGF-beta1 may be a critical risk factor of genetic susceptibility to gastric cancer in the Chinese population, Genetic background of TGF-beta1 may be involved as a protective factor in the development of aGVHD in HLA-matched sibling BMT in Iranian population., These results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with cytomegalovirus., frequency of AFP(46-55) CD4(+) T cells is significantly higher (p = 001) in patients with hepatocellular carcinoma than in healthy donors, Lower level gene expression in patients treated with Cyclosporine A may be considered to be a risk factor for gingival overgrowth, results establish the heterogeneous responsiveness of fibroblast populations in the airways to TGF-beta(1) & that such a heterogeneity may contribute, at least in part, to the different pathological outcomes of inflammation in the upper and lower airways, Tryptase activates TGFbeta via a PAR2-independent proteolytic mechanism in human ASM cells and may help understanding the role of tryptase in asthma., data suggest that the altered TGF-beta1 levels are associated with the presence of Hashimoto's thyroiditis, not with the treatment of thyroid dysfunction., study suggests polymorphisms of IL10, TNFalpha & TGFbeta1 do not have major independent role in acute rejection (AR)& hepatitis B virus(HBV)recurrence after liver transplantation & may not be risk factors of AR & HBV recurrence after liver transplantation, secretary factors of adipose-derived stem cells inhibit melanin synthesis by down-regulating the expression of tyrosinase and tyrosinase-related protein 1, which are mainly mediated by TGF-beta1, TGFbeta1 activity during liver fibrosis is specifically antagonized by pleiotrophin, transforming growth factor-beta1 indirectly reduces antigen-presenting cell density in EpM by affecting E-cadherin expression, which might explain the increased susceptibility of abnormal tissue differentiation., This study demonstrates an interplay between TGFbeta1, IL-13 and CCL2 in idiopathic pulmonary fibrosis with a usual interstitial pneumonia histological pathology, where these three mediators feedback on each other, promoting the fibrotic response., Mesenchymal stem cells from patients with osteoarthritis showed significantly increased total TGF-beta, TGF-beta1 isoform, TBR-II, and TBR-III mRNA expression compared to controls., Consistent with our gene expression data, multiple soluble mediators associated with inflammation and tissue remodeling were markedly elevated in the bronchoalveolar lavage fluid of mice expressing hTGF-beta1, These data indicates that full-length WISP-1 and its variant WISP-1va are modulators of proliferation and osteogenic differentiation, and may be novel regulators of TGF-beta1 signaling in osteoblast-like cells., TGF-beta/Smads signaling pathway play a important role on cell growth and metastasis potential in oral squamous cell carcinoma., Relaxin decreased the levels of total and active TGF-beta1 in the extracellular matrix isolated from stress urinary incontinence vaginal fibroblasts., A TGFB1 haplotype was highly associated with increased lung function in patients grouped by CFTR genotype., The aberrant methylation of TSP1 is a novel epigenetic mechanism for suppressing TGF-beta signaling in colorectal cancer., Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced ERK1 and ERK2 activation and promotion of migration and invasion of esophageal cancer cells, Foxp3 mRNA as well as Foxp3 protein was detected in all tumor cell lines, correlating with the expression levels of IL-10 and TGFb1, TGFbeta1 are likely to be involved in HESC decidualization, in HLFs derived from patients with ILDs, the proliferative mechanisms activated by TGF-beta1 are at least in part mediated by an increased release of IL-6, leading to phosphorylation-dependent MAPK activation, TGF-beta(1) production in carcinoma cells was associated with doxorubicine-mediated p53 expression in MCF-7 cells or high basal level of p53 in T47D cells., Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells., The ability of TGF-beta to induce degradation of Ski could be an additional mechanism contributing to its protumorigenic activity., mature human M2 macrophages made permissive to TGF-beta by glucocorticoid-induced surface expression of TGF-betaRII activate in response to TGF-beta1, Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5., These results describe a novel mechanism for the potentiation of TGF-beta1 signaling to induce MMP-9 expression via Smad and MLCK., T(3) regulates furin gene expression via a novel mechanism or in cooperation with TGF-beta to enhance tumor metastasis in vitro and in vivo., fibroblasts from subjects with COPD produced more transforming growth factor (TGF)-beta1, but manifested reduced response to TGF-beta1, Down-regulation of TCF8 expression in ATLL cells was associated with resistance to TGF-beta1, a well-known characteristic of ATLL cells, suggesting that escape from TGF-beta1-mediated growth inhibition is important in the pathogenesis of ATLL, TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4(+) T cells into T(H)17 cells accompanied by expression of the transcription factor RORC2, T beta RI sumoylation controls responsiveness to TGF-beta, with implications for tumour progression, More ductular-type progenitors and fibrosis markers were noted in HF+EtOH mice than in HF mice. The former also expressed more TGF-beta-1., Treg cells were deficient in peripheral blood but not impaired in TGF-beta1 expression or in response to TGF-beta1 stimulation in patients with systemic lupus erythematosus., tumor-induced TGF-beta may actively subvert the CD8+ arm of the immune system into directly promoting tumor growth by an IL-17-dependent mechanism, In the combined region of the 19q13 loci for IA and AAA we identified two candidate genes that are both involved in the TGF-beta signalling pathway., TGF-beta suppressed iNKT cell activation and proliferation and IFN-gamma production while IL-10 was identified as a cytokine involved in stimulating the activation and expansion of iNKT cells that could subsequently suppress NK cell and T cell responses., FK506 has an effect on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells, The TGFbeta1 SNPs studied modulate age at diagnosis and penetrance of familial pulmonary arterial hypertension in BMPR2 mutation heterozygotes., study found different expression of the TGF-beta1, -2 and -3 isoforms in the human corneal epithelium; such differential expression of TGF-betas suggests that each of them may play a specific role in corneal tissue, HDAC6 is a critical regulator of TGF-beta1 induced epithelial-mesenchymal transition and a potential therapeutic target against pathological epithelial-mesenchymal transition, a key event for tumor progression and fibrogenesis, Opposite effects of transforming growth factor-beta activation and rho-associated kinase inhibition on human trophoblast migration in a reconstituted placental-endometrial coculture system., the TGF-beta1-2-3/Smad3 pathway has a role in mediating ovarian oncogenesis by enhancing metastatic potential, Expression of Smad2 is increased in normal NIH-3T3 cells after treatment with recombinant human TGF-beta1; Smad3 is more sensitive to TGF-beta1 than Smad2., Temporal TGF-beta gene expression signature established in mouse primary hepatocytes successfully discriminated distinct subgroups of hepatocellular carcinoma and lung adenocarcinoma in humans., TGF-beta1 might participate in the biological behavior of acoustic neuroma., Concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies., study explored the functional consequences of constitutively activating TGF-beta signaling in genetically engineered epidermal melanocytes, Both circulating TGF-beta1 and TGF-beta1 mRNA can be used as sensitive biomarkers for the diagnosis and prognosis of HBV-induced HCC., TGFB1 L10P genotype does not modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, Integrin alphavbeta6 is strongly up-regulated in proliferating bile duct epithelia and drives fibrogenesis via adhesion to fibronectin and auto/paracrine TGF-beta1 activation., MT1-MMP-dependent TGFbeta signaling through Alk5 is also required for PGE(2)-induced endothelial cord formation in vitro, and Alk5 kinase activity is required for PGE(2)-induced neovascularization in vivo., TNF[alpha] -308, -238, and TGF [beta]1 -509 SNPs and the TNF[alpha] -308A/-238G haplotype were associated with age-related decline in FEV1 in a group of firefighters., Transforming growth factor beta (TGF-beta) plays an important role in cells proliferation and differentiation as well as in local immunological response., TGF beta 1 polymorphisms (C allele at - 509C>T, T allele at codon10 T>C) contribute to progression of hepatic fibrosis in Chinese with hepatitis B virus infection., Viral gene expression, and specifically the activity of the BKV early promoter, is regulated by TGF-beta in a strain-dependent manner., levels of TGF-beta1 in induced sputum are elevated in asthmatic patients despite treatment with inhaled corticosteroids; TGF-beta1 is involved in the pathogenesis of airway remodeling and resultant functional impairment, the combination of the GG genotype of EGF and the CT genotype of TGFB1 demonstrated synergistic increase in risk of gallbladder cancer, The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry., EGF contributes to differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-receptor activation and is important modulator of wound healing and scar tissue formation., Our data do not justify genotyping of the investigated single nucleotide polymorphisms (SNPs) to assess the development of renal dysfunction post-HTx., These data reveal an essential level of TGFbeta signaling regulation mediated by Hsp90., fibrinogen-Mac-1 receptor binding, through induction of IL-1beta, drives the synthesis of transforming growth factor-beta (TGFbeta) by mdx macrophages, which in turn induces collagen production in mdx fibroblasts., TGF-beta1 or activin A but not BMP-2 significantly decreased significantly decreased melanin content and expression of Tyrosinase and Tyrp-1 in the absence of alpha-MSH in melanoma cells, Erythromycin A and EM703 inhibit TGF-beta signaling in human lung fibroblasts via inhibition of p-Smad2/3 through recovery of Smad7 level., MT1-MMP-mediated proteolytic processing of ECM-bound LTBP-1 is a mechanism to release latent TGF-beta from the subendothelial matrix., EBV lytic phase induction in alveolar epithelial cells increased active and total transforming growth factor-beta1 (TGFbeta1) transcript expression, No association was detected between the TGFB1, IL10, TP53, and HMOX1 genes and DGF. The G allele of the TNF polymorphism rs3093662 was associated with DGF in an adjusted analysis., 17beta-estradiol regulates the secretion of TGF-beta by cultured human dermal fibroblasts, TGFB has paradoxical and context dependent effects on proliferation and anoikis in colorectal cancer cell lines., Results imply that androgen signalling through the androgen receptor may positively or negatively regulate TGF-beta1 expression in response to various signals or under different environmental conditions., H. pylori-positive patients revealed a high induction of FOXP3 transcript which correlated positively with inflammation and TGF-beta1 levels., One significant haplotype of TGFB1 is associated with the emphysema phenotype in the Japanese population. Two TGFB1 single nucleotide polymorphisms are associated with the severity of COPD in patients with emphysema phenotype., This study demonstrates increased plasma levels of TSP1, which correlated with increased levels of proinflammatory cytokines in plasma of rheumatoid arthritis patients., Data show that IGF2 activates PI3K and TGFbeta signal pathways during proliferation and differentiation of chondrocytes., The positive correlation of glomerular p-smad2/3 positivity with proteinuria further supports the importance of the TSP-1/TGF-beta system as a relevant mechanism for progression of type-2 diabetic nephropathy, inhibition of TGF-beta1 ligand may act as a negative feedback loop to disrupt the function of all TGF-beta isoforms, Dysregulation of TGFbeta signaling as a possible link between Pez mutation and cancer progression., These data suggest that ADAMTSL2 mutations may lead to a dysregulation of TGF-beta signaling and may be the underlying mechanism of geleophysic dysplasia., The expressions of TGF-beta1 and Smad7 were significantly increased in epithelia of oral lichen planus compared to normal oral mucosa., Ther is an association between the transforming growth factor-beta1 (TGF-beta1) gene polymorphisms rs1800469 (commonly known as T-509C) and rs1982073 (commonly known as Leu (10)-->Pro) and primary vesicoureteral reflux (VUR) and renal scarring., ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression., TGF-beta signal transduction is abnormal in B-cell type acute lymphocytic leukemia., Polymorphism of codon25 in the signal peptide region of TGFb1 may contribute to the outcome of HCV infection., Examine the role of transforming growth factor-beta1 signaling pathway in pathogenesis of benign biliary stricture., stromal cell-derived factor-1 and transforming growth factor-beta control the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin, although TGFbeta1, an important cytokine in immune regulation, was elevated in monoclonal gammopathies, the SNPs in coding region of TGFbeta1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study, TGFbeta activates PI3K to downregulate PTEN for enhancement of cell proliferation that is independent of SMAD proteins, TGFbeta now stimulated the constitutive TCF transcriptional activation activity associated with the beta-catenin/Wnt pathway in the APC knocked-down cells, TGF-beta1 and SMAD3 may be involved in the pathology of corneal diseases associated with herpes simplex virus type 1 infection., These studies identify F-spondin as a novel protein in osteoarthritis cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation., AZX100, an analogue of the small heat shock protein, HSP20, reduces TGF-beta1-induced CTGF expression in keloid fibroblasts, The tubular and interstitial TGF-beta1 and HIF-1alpha expressions in chronic kidney allograft nephropathy are greater than in other groups., TGF-beta1 single nucleotide polymorphisms are not significantly associated with increased risk of chronic allograft nephropathy and graft survival in Korean renal transplant recipients., The expression of TGF-beta occurs in both granulosa cells and thecal cells throughout antral follicle development., Established liver fibrosis patients had the homozygote G/G TGF-beta genotype, which has been associated with increased development of fibrosis. None of our patients had the G/C genotype., These data suggest that SOCS-1 inhibits high glucose-induced overexpression of TGF-beta1 and synthesis of fibronectin in human mesangial cells, which may be via JAK/STAT pathway., Observed airway smooth muscle cell differentiation into a more contractile asthma phenotype is driven by the autocrine release of TGF-beta 1 in response to activation by mast cell beta-tryptase., polymorphism of the TGF-beta1 gene may be involved in susceptibility to brucellosis and to developing focal forms of the disease in a group of patients from southern Spain., Data suggest that TGF-beta1 single nucleotide polymorphisms probably facilitate the development of liver cirrhosis, while they seem to have a limited role in predicting the occurrence of hepatocellular carcinoma., TGFbeta and retinoic acid downregulated the expression of p63 in immortalized nasopharyngeal epithelial cells and may play a role in regulating differentiation in squamous epithelial cells, The aim of this study was to analyze the effect of TGF-beta targeting on the expression of angiogenic vascular endothelial growth factor (VEGF), in fibroblasts isolated from radiation-induced chronic dermal wounds., Data suggest that TGFB1 gene polymorphism is associated to clinical characteristics suitable to recognize hypertensives with a higher severity of hypertension., a complex role of TGF-beta1 in breast cancer progression, TGFBI promoter methylation can be used as a potential prognostic marker for invasiveness and metastasis in prostate and lung cancer patients., Different roles for TGF-beta and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy, Results describe a new function for the TGF-beta pathway in the regulation of APC to mediate chromatid separation during mitosis., clathrin-independent endocytosis of T beta RIII has a role in regulating both Smad-dependent and Smad-independent TGF-beta signaling, TGF-beta induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways., Heptatocellular carcinoma-derived TGF-beta1 may act as a chemoattractant for CD105-expressing endothelium and as a promoter of tumor angiogenesis., Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group., mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta., the incidence of TGFB1(transforming growth factor beta 1) *CC polymorphism was lower in Behcets disease cases than controls, Finds lack of association between functional polymorphisms in TGF-beta 1 gene at positions -509, +869 (codon 10), and +915 (codon 25) and silicosis and pulmonary tuberculosis in Chinese iron miners, Elevated miR-21 expression may facilitate breast cancer progression, and TGF-beta may up-regulate its expression, The association between TGF-beta1 polymorphism and virologic characteristics of chronic HCV infection implicated a significant role of host genetic factors on the clinical features of CHC., Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1, TGF-beta plays a critical role in mediating cicatricial contraction in proliferative vitreoretinal diseases., Rosiglitazone inhibits the proliferation and migration of Tenon's capsule fibroblasts by decreasing TGFbeta1., Binding elements for ETS and transcription factor AP-2 (TFAP2) were significantly enriched in Smad2/3 binding sites, and knockdown of either ETS1 or TFAP2A resulted in overall alteration of TGF-beta-induced transcription., TGF-beta(transforming growth factor beta1), PDGF-AB (platelet derived growth factor AB) and bFGF (basic TGF-beta, PDGF-AB and bFGF) concentrations in subacromial space were higher than in the serum, High TGF-beta1 in serum is associated with gestational trophoblastic disease., Expression of TGF-beta1 increased significantly 6 mo - 2 y in long-term denervated posterior cricoarytenoid muscles, but after 3 years of denervation, there was no expression at all., dynasore may stimulate PAI-1 protein expression and enhance TGF-beta(1) activity through activation of JNK-mediated signaling in human pleural mesothelial cells, TGF-beta and IL-10 redundantly suppress hepatic inflammation during acute S. mansoni infection while intestinal inflammation is regulated by alternatively activated macrophages., TGF-beta affects human skin mast cells by attenuating degranulation and cytokine production, This study has demonstrated that constant cyclic stretching inhibits adipogenic differentiation of human umbilical cord progenitor cells via autocrine/paracrine stimulation of the TGFbeta1/Smad2 signaling pathway., This study is the first study to use a cell line with a low metastatic rate and TGFbetaRII mutations to demonstrate that restoring TGFbeta signalling increases the metastatic rate., activation of TLR3 can affect the differentiation to myofibroblasts and enhance ECM production via the NF-kappaB-TGF-beta(1)-dependent pathway, 7 different common variants in TGFB1 and TGFBR1 were not associated with an increased risk of bladder cancer, the interplay between NF-kappaB and C/EBPbeta has an impact on the ability of C/EBPbeta to stimulate TGF-beta1 transcription., sTbetaRII attenuates the biological activities of TGF-beta in colorectal cancer, Increased TGFbeta1 is associated with systemic lupus erythematosus., TGFbeta1 and hepatocyte growth factor were major mediators of T-cell suppression by MSCs derived from ALL, HD and NHL, high levels of TGF-beta1 in healthy bowels of patients who undergo ileo-colonic resection for Crohn's disease associated with early clinical disease recurrence, TGF-beta1, VEGF and NO probably have a role in the pathogenesis of Hashimoto's thyroiditis, and development of autoimmunity, Fractalkine and TGF-beta1 levels reflect the severity of chronic pancreatitis in humans., These results indicate that Ski complexes serve to maintain a TGF-beta-responsive promoter at a repressed basal level via the activities of histone deacetylase and histone arginine methyltransferase., analysis of genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility, hypoxic pulmonary artery smooth muscle cells produce TGF-beta1 that acts in an autocrine fashion to induce IGFBP-3 through PI3K/Akt, Data show no difference between serum concentrations of transforming growth factor-beta1 and ferritin in fatty liver and non-alcoholic steatohepatitis, suggesting that these forms share more common aspects than previously thought., TGFB1 polymorphism L10P is not strongly associated with prostate cancer risk, Transforming growth factor (TGF)-beta might be a central mediator of tissue fibrosis and remodeling in patients with long-standing and recently diagnosed asthma, The presence of SNP (+915G/G) at codon 25 in TGF-beta1 gene may predispose to the development of irreversible bronchoconstriction in asthmatic patients, but only when coincident with the male gender, habitual smoking and relevant duration of the disease., inhibition of caspase-8 by siRNA knockdown partially rescues the apoptotic effects of TGFbeta1, suggesting a role for death receptor signaling components in TGFbeta-mediated death of prostate epithelial cells, Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice., The study does not support the association of high myopia with alleles of rs2229336 in TGIF, rs3759223 in lumican, rs1982073 in TGFB1, and rs3735520 in HGF., TGF-beta cytokines may be involved in postsurgical adhesion formation, A new mutation in TGFBI gene, Leu558Pro, was identified in the patients with atypical lattice dystrophy., TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation., inhibition of TGF-beta1 suppresses motility and invasiveness of human oral squamous cell carcinoma cells, Results suggest that an epithelial cell response to TGF-beta signaling regulates commitment to cell death and suppression of lactation during the second phase of mammary involution., C-peptide almost completely reversed the morphological changes in proximal tubule cells induced by TGF-beta1., Study in Costa Rica indicates single nucleotide polymorphisms in TGFB1 are associated with airway responsiveness and disease exacerbations in children with asthma. Dust mite exposure may modify the effect., Three SNPs in the Black population that are rare in the Europen population of otosclerosis are SNP2-rs1982073, SNP3-rs1800471 and ZAP-C 100, TGF-beta1 promotes vascular invasion in hepatocellular carcinomas by activating beta1 integrin., preoperative plasma TGF-beta 1 levels in patients with operable breast cancer were significantly higher than healthy controls; those with positive sentinel lymph node had significantly higher levels than those with negative sentinel lymph nodes, These data suggest that TGF-beta is not critical for the differentiation of human Th17 cells, but indirectly favors their expansion because Th17 cells are poorly susceptible to its suppressive effects., transforming growth factor beta(1) (TGF-beta(1)), a pleiotropic cytokine regulating inflammatory reactions.TGFB1 gene polymorphisms (-800G>A, -509C>T, 869T>C, and 915G>C) are not associated with allergic asthma in a Polish population, TGFbeta1 genetic polymorphisms at codon 10 may be involved in a differential susceptibility to T. cruzi infection in these South American samples., These findings suggest that the -509C>T polymorphism in the TGFbeta1 promoter may contribute to the development of the aspirin-intolerant chronic urticaria phenotype, ox-LDL is significantly correlated to TGF-beta in type 2 diabetic patients, HIF-1 alpha and GLUT-1 could cooperate with TGF-beta1, and TGF-beta1 might mediate cross-talk between the inflammatory environment and tumour with a favourable impact on patient survival in colorectal cancer, MMP-9 could up-regulate collagen deposition, possibly through TGF-beta activation, TGF-beta1 elevates TbetaRII homodimerization to some degree and strongly enhances TbetaRI.TbetaRII heteromeric complex formation., The median plasma TGF-beta1 level was similar in all examined groups, but the greatest range of individual plasma TGF-beta1 levels is found in Balkan endemic nephropathy patients., The plasma TGF beta 1 levels change with age. In addition, TGF beta 1 may play a role in the pathogenesis of bronchial asthma., High-affinity binding of TGF-beta1/3 to TGF-betaRII is primarily due to hydrogen bonding between Arg25 and 94 of TGF-beta1/3, and Glu119 and Asp32 of TbetaR-II. Arg25 and 94 are substituted by Lys in TGF-beta2, which binds with low affinity to TbetaR-II., -509C>T polymorphism in the TGF-beta1 gene promoter, impact on the hepatocellular carcinoma risk patients with chronic hepatitis B virus infection., genetic variants are associated with the decreased frequency of Treg in Systemic Lupus Erythematosus patients, In contrast to its link with the ACE D/I genotype, microalbuminuria was independent of TGF-beta-1 polymorphism in a group of never-treated, uncomplicated essential hypertensive men., In newborns of allergic fathers TGF-beta1 levels were significantly lower than in newborns of non-allergic parents., TGF-beta may facilitate airway remodelling by promoting VEGF release through the PI3K pathway, rather than via ASM cell proliferation., myofibroblasts in areas of fibrosis maintain their own phenotype through autocrine TGF-beta1 action, Conservation of the identified hydrophobic motifs in the pro- and mature domains of other transforming growth factor beta superfamily ligands suggests that we have identified a common biosynthetic pathway governing dimer assembly, hENT1 is down-regulated by activation of TbetaRII by TGF-beta1 in endothelium from umbilical veins., disruption of Smad2 function by CDK2 phosphorylation acts as a mechanism for TGF-beta resistance in multiple myeloma, Taking into account that most rare missense alleles are thought to have a biological effect, the data suggest that multiple rare amino acid changing variants in TGF-beta1 may contribute to susceptibility to otosclerosis., HBx may facilitate liver fibrosis by promoting hepatic stellate cell proliferation and upregulating the expression of fibrosis-related molecules like TGFB1, results indicate that TGF-beta1 participates in the regulation of basal expression and the stretch-induced expression of IL-6 and suggest the possible existence in cultured human trabecular meshwork cells of an autocrine loop between IL-6 and TGF-beta1, Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., TGF-beta-induced phosphorylation of Smad3 linker sites inhibits its antiproliferative activity, A novel L558P mutation in the TGFBI gene causes an atypical type of stromal corneal dystrophy, TGFbeta activates the transcription factors Smad2 protein and Smad3 protein, inhibits proliferation, and blocks Cdk2 protein activity., TGF-b 1 promoter polymorphism may positively contribute to the development of AIA with rhinosinusitis through gene interaction., TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in Renal clear cell carcinoma patients., the hallmark of our panel of activated human Treg clones is to produce bioactive TGF-beta which has autocrine actions on Tregs and can have paracrine actions on other T cells., TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner, TGF-beta1, TGF-betaR1 and TGF-betaR2 gene polymorphisms are not associated with childhood acute lymphoblastic leukaemia., Adipose tissue-derived mesenchymal stem cells differentially respond to BMP-2 and TGF-beta1 with changes in gene expression of collagen-modifying enzymes., a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas, After treating of NB4 cells with As(2)O(3), P27(Kip1) and endogenous TGF-beta1 mRNA expressions were up-regulated, and cyclin E mRNA expression was down-regulated., TGF-beta1 overexpression may be associated with in the development and progression of ligamentum flavum degeneration in the lumbar spine., TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis., TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro., TGFB1 stimulation of lung epithelial cells leads to an increase in the cytosolic localization of KH-type splicing regulatory protein, far upstream element-binding protein, hnRNP-L, and hnRNP-H1, concomitant with a decrease in their nuclear localization., sEng levels, but not TGF-beta1 levels, showed a positive correlation with maximum diastolic and systolic blood pressure., TGF-beta mediated epithelial mesenchymal transition has a role in progression of autosomal dominant polycystic kidney disease, Experiments with T cells from healthy donors in the presence TGF-beta1 or IL-10 suggest that these cytokines have a relevant role in T cell responses during cervical cancer progression., Genetic polymorphism of the TGFB1 signal sequence is associated with the response to chemoradiotherapy in head and neck squamous cell carcinoma patients., TNF-alpha abrogated TGFbeta1-induced SMalphaA gene expression at the level of transcription without disrupting phosphorylation of regulatory Smads., Hepatitis B virus X protein shifts hepatocytic TGF-beta signaling from the tumor-suppressive pSmad3C pathway to the oncogenic pSmad3L pathway in early carcinogenic process., The genetic polymorphism at -509 C/T but not at -800 G/A of the TGFB1 gene may play a role in susceptibility of Iranian subjects for colorectal carcinoma., combination of CTLA-4 and TGFbeta1 polymorphisms is associated with the susceptibility of DHF and higher virus load., TGF-beta1 caused apoptosis of pulmonary microvascular endothelial cell, an effect that was also dependent on ALK5 activity., gene expression is decreased following treatment with apigenin, Serum TGFB1 protein levels were positively and significantly associated with plasma renin activity along with the systolic and diastolic blood pressure in blacks but not whites after controlling for age, gender, and body mass index., The effects of shockwave on bone healing and systemic concentrations of TGF-beta1, we review recent findings that directly impact our understanding of the TGF-beta paradox and discuss their importance to targeting the oncogenic activities of TGF-beta in developing and progressing neoplasms, Increases in TGF-beta1 gene expression and its protein level, associated with altered TGF-beta1 receptor profile indicate a functional role for TGF-beta1 in intestinal inflammatory/repair processes in ulcerative colitis., role for RanBP3 in mediating Smad2/3 nuclear export and terminating TGF-beta signaling, There is disregulation in expression of the TGFB1 gene and its receptors as well during isolated Raynaud phenomenon as in systemic sclerosis., TGFbeta1 stimulates VEGFD/VEGFR3 receptor axis activation leading to increased cell migration and invasion by primary intermediate prostate cancer basal cell cultures, 9-ONC might thus sustain further vascular remodeling due to atherosclerosis, not simply by stimulating synthesis of the pro-fibrogenic cytokine TGF-beta1 in vascular cells, but also and chiefly by enhancing the TGF-beta1 autocrine loop., Losartan can reverse left ventricular hypertrophy in elderly patients with essential hypertension partially by lowering plasma TGF-beta1 level., TGFB1 inhibits luteinization in cultured bovine granulosa cells while maintaining an estrogenic phenotype, and this effect was associated with increased apoptosis., There were no correlations among serum TGF-beta1 and pulmonary function test parameters, duration of asthma, and duration of inhaled corticosteroid treatment. These data support the role of TGF-beta1 in airway remodeling in asthma., Helicobacter pylori CagA-positive patients with TGF-B1 -509 T allele had a higher risk for gastric atrophy and lymphoid follicle development., TGF-beta/activin receptor-like kinase-5 signaling is, in part, involved in the regulation of BBB functional integrity, Regulatory cytokines, interleukin (IL)-10 and transforming growth factor (TGF)-beta, were significantly raised in infectious mononucleosis compared to seropositive donor plasma., plasma level is higher in asthmatics, Study shows that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63., TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma., Disruption of TGF-beta signaling in diffuse-type gastric carcinoma models appeared to accelerate tumor growth, apparently through increased tumor angiogenesis that was induced by decreased expression of thrombospondin-1., Overexpression of Smad7 has been shown to antagonize TGF-beta-mediated fibrosis, carcinogenesis, and inflammation, suggesting a therapeutic potential of Smad7 to treat these diseases., TGF-beta1 drives GATA-4 expression during intestinal inflammation, these two components cooperating to promote epithelial healing., Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway., upregulation of TGF-beta1 pathway plays an important role in NB4 cells differentiation induced by all-trans retinoid acid, TGFB1 is the first myopia susceptibility gene successfully replicated. The functional significance of rs4803455 or the genuine causative SNPs in linkage disequilibrium with it remains to be determined., transition to increased aggressiveness in melanoma cells requires Id2 upregulation to suppress TGF-beta induction of p15(Ink4b) and thus help to circumvent TGF-beta-mediated inhibition of proliferation., Our results indicate a permanent repression of PAI-1 by ERalpha and suggest a ligand-independent crosstalk between ERalpha and TGF-beta signaling in breast cancer cells., Apoptosis of APL cells induced by As(2)O(3) may be caused by up-regulating TGF-beta1 and P27(Kip1)., Results showed that CT/CC genotypes of TGFbeta1 rs1982073, This study shows that the disappearance of CD34-positive stromal cells and appearance of alpha-SMA-positive stromal myofibroblasts may be associated with transformation of cervical cervical intraepithelial neoplasias to squamous cell carcinomas., Sustained restoration of circulating latent TGFB1 to levels approaching the normal physiological range does not rescue the infertility phenotype caused by TGFB1 deficiency., ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21., up-regulation in human colorectal cancer is correlated with upregulation of the TIMP-1 transcript, Suppression of TNF-alpha on TGF-beta-induced CTGF expression is due to the competition of p300 by p65 and Smad4., A dose-dependent increase in viable cells was demonstrated after the IPL irradiation. There was no significant change in mRNA levels of collagen I and fibronectin., and collagen synthesis while VEGF deteriorate tendon properties via vessel formation and destruction of the collagen network., Genotype distributions examined in 38 recipient-donor pairs with either low-grade or high-grade aGVHD did not find significant differences, but some trends were noted in genotype distributions among aGVHD-grade groups, Human atrial fibrogenesis in patients with atrial fibrillation is accompanied by a biphasic response, an early increase and later loss of responsiveness to TGF-beta(1), REVIEW, The intracellular concentration of TAL1 is regulated by TGF-beta, which triggers its polyubiquitylation & degradation by the proteasome. This is mediated by AKT1, which phosphorylates TAL1 at threonine 90., TGF-beta1 inhibited expression of toll-like receptors and attenuated odontoblast responses, suggesting the balance between TLR-mediated inflammation and TGF-beta1 anti-inflammatory activity plays an important role in pulpal inflammation., Pleural mesothelial cells activated by TGF-beta1 undergo epithelial-mesenchymal transition (EMT) and respond with haptotactic migration., induction of membrane-bound TGF-beta1 by IFN-gamma and/or TNF-alpha occurs through de novo synthesis., There is no association between TGFB1 and bone density T(861-20)-C polymorphism in Turkish postmenopausal women., Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription, Increased expression of integrin alpha2 and the increased response to TGF-beta1 of hereditary gingival fibromatosis (HGF) fibroblasts may be related to the excessive collagen deposition in HGF patients., TGF-beta1 was up-regulated in endometrial cancers., loss of TGFbetaRII in hepatocellular carcinoma triggers activation of the TNF pathway known to be regulated by TGF-beta(1) network, TGF-beta type I receptor inhibitor LY364947 blocked the up-regulation on TGF-beta(1) and TGF-beta(3) production stimulated by mechanical load, and also blocked the chondrogenesis of human mesenchymal stem cells., Data show that lack of dioxin receptor increases TGFbeta levels, keratinocyte migration and accelerates skin re-epithelialization without affecting cell proliferation or recruitment of inflammatory cells., Recipient RAAS polymorphisms are associated with a higher risk of rejection, graft cytokine expression, graft dysfunction, and a higher mortality after cardiac transplantation., Results show there was high risk of biochemical recurrence associated with tumors that displayed high levels of expression of TGF-beta1, vimentin, and NF-kappaB and low level of cytokeratin 18., TGF-beta signaling mediates intrinsic, stromal-epithelial, and host-tumor interactions during breast cancer progression, at least in part, by regulating basal and oncostatin M-induced CXCL1, CXCL5, and CCL20 chemokine expression, TGF-beta induces phosphorylation at three sites in the Smad3 linker region in addition to the two C-terminal residues., (PPAR)delta regulates extracellular matrix synthesis and degradation through transforming growth factor-beta1 and its effector, Smad3, Data show that inhibitors of clathrin-dependent endocytosis inhibit internalization of cell-surface-bound TGFbeta and promote colocalization and accumulation of TbetaR-I and SARA at the plasma membrane., Active TGFB1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence., pathogenesis of glioma formation may involve altered AhR regulation of the TGF-beta/Smad pathway, and AhR may represent a promising target for the treatment of human malignant gliomas and other diseases associated with pathological TGF-beta activity, In relation to the T869C polymorphism in the TGF-beta1 gene, results we found an association only between the TC heterozygote and mild lung disease in cystic fibrosis., [review] Emerging evidence indicates that much remains to be discovered regarding the complex and intertwined roles of TGF-beta in inflammation, T cell lineage commitment, antibody generation, immune suppression, and tolerance., Findings suggest that TGFBI and periostin may play cooperative cellular roles and that periostin may be involved in the pathogenesis of 5q31-linked corneal dystrophies., [review] Recent studies highlight the importance of regulatory cytokines TGF-beta, interleukin (IL)-10, and IL-22 in controlling differentiation and function of lymphocytes under steady-state and inflammatory conditions, and minimizing tissue damage., [review] The TSP1/transforming growth factor beta/ connective tissue growth factor axis may contribute in the pro-inflammatory and pro-atherogenic state in patients affected with rheumatoid arthritis., PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease., Combined analysis of EGF+61G>A and TGFB1+869T>C functional polymorphisms in the time to androgen independence and prostate cancer susceptibility., TGFB1 promoter SNPs may not be associated with the risk of childhood pre-B acute lymphoblastic leukemia among French Canadians, TGFbeta stimulates Bim transcription by up-regulating the expression of the transcription factor Runx1 through an internal ribosome entry site -dependent mechanism., Ras/MAP kinase pathway, specifically through N-Ras, mediates TGFbeta1 auto-induction and TGFbeta1-induced CTGF expression in human renal tubule epithelial cells., Studies demonstrate the profound significance of TGFB1 in male and female reproductive physiology, and provide a foundation for exploring the significance of this cytokine in human infertility and sexual dysfunction., TGF-beta1 is not associated with the occurrence of restenosis at one year of follow-up of PTCA patients., Data demonstrate a unique functional connection between pRB and TGF-beta in growth control and mammary gland development., CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells., TGF-beta1 may participate in some pathologic changes in vocal cord polyps., Circulating TGFB1 is a reliable biomarker for chronic kidney disease progression in the African-American population., Immunohistochemical study showed moderately elevated expression of TGF-a in endotheliocytes. in all arteriovenous and venous malformations, xIAP has a role in mediating oncogenic signaling by TGF-beta and NF-kappaB in breast cancer cells, IL-17, IFNgamma and TGFbeta levels in CD45Ro and CD45Ra cells from systemic sclerosis patients are differently expressed in lSSc, ldSSc or edSSc phenotypes, PPARdelta plays an important role in skin wound healing in vivo and that it functions by accelerating extracellular matrix-mediated cellular interactions in a process mediated by the TGF-beta1/Smad3 signaling-dependent or - independent pathway., There is an important relationship between the abnormal TGF-beta1/Smad4 signal pathway and genesis and development of oral squamous cell carcinoma., soluble factors in SSc plasma inhibit Treg function specifically that is associated with altered Treg CD69 and TGFbeta expression, Data show there was a significant correlation between the level of TGF-[beta]1 and the levels of MMP-2 and TIMP-2 immunostainings in pancreatic ductal epithelium., The TGF-beta1-acetylcholine axis may regulate colon carcinoma progression and metastasis by altering nitric oxide secretion and influence inflammatory responses by modulating IL-1beta production., Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury., Polymorphisms of TGFB1 genes and survival of patients with gastric cancer, PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells., The rate of TGF-beta1-induced osteoclast apoptosis was lower when Bim expression was suppressed., polymorphisms of TGF beta 1 codons 10 and 25 were associated with susceptibility or resistance to brucellosis., The prognostic value of TGF-beta and VEGF in follicular lymphoma is determined in serum samples, suggesting their contribution to tumor microenvironment alterations., TGF-beta1 stimulates expression of activating transcription factor 3 (ATF3) in human breast cancer cells (MDA-MB231)., TGF-beta1 functions to couple bone resorption and formation., Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein, the present study demonstrated an involvement of TGF-beta1 in the pathogenesis of idiopathic portal hypertension., The TGF-beta1 -509C/T polymorphism is associated with increased risk for chronic idiopathic neutropenia and contributes to the pathophysiology of the disorder by inducing TGF-beta1 overproduction., the renin-angiotensin system and TGF beta 1-related fibrogenic loops are activated as early as 2 months after kidney transplantation., increased serum levels in allergic rhinitis patients following specific immunotherapy; correlation with symptom severity, Compared with human fallopian tubes without adhesions or atresias, the expression of TGFbeta1, TGFBR1 and TGFBR2 all increased significantly in adhesion cases., neither VEGF nor TGF-beta1 can be used as biochemical markers for an early diagnosis in HHT., Transforming growth factor (TGF)-beta induced Nerve growth factor (NGF) and its two receptors in pancreatic stellate cell lines by acitivation of ALK-5 pathway., transforming growth factor beta has a role in the regulation of thyroid function and growth [review], TGF-beta1/TNF-alpha secreted by breast tumor cell lines induce reversion of mammary adipose cells to a fibroblast phenotype., Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes., Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide., Study found that ERK and JNK pathways are involved in TGF-b1-induced fascin1 expression in the human gastric cancer cell line MKN45., Synthesis of activin and TGFB-signaling modulators may be affected by spermatogenic disruption and altered hormone levels in the testis., These results suggest that the increased activity of TGF-beta1 may underlie the depressed function of T cell responses with consequent prolongation of disease course in patients with chronic brucellosis., the TGFbeta-Par6 polarity pathway has a role in breast cancer progression, These results suggest that KLF5 is not only essential for MYC transcription in proliferating epithelial cells but also mediates the inhibitory effect of TGFbeta on MYC transcription., no increase found in interstitial pneumonia, TGF-beta1 plays an important role in the progress of glomerular sclerosis, renal tubular injury and interstitial fibrosis in children with IGA nephropathy., These data demonstrate that the differentiation of normal human lung fibroblasts to myofibroblasts is HDAC4 dependent and requires phosphorylation of Akt., CC genotype of TGF-beta1 polymorphism at codon 10 is associated with occurrence of Giardiasis, gammadelta T lymphocytes with regulatory functions (Vdelta2 Tregs) are induced in vitro in the presence of specific Ag stimulation and cytokines TGF-beta1 and IL-15., TGFbeta signaling has a role in the pathogenesis of psoriasis [review], The study concludes that increasing numbers of single nucleotide polymorphisms in codon 10 of TGFB1 in patients and donors are associated with a worse outcome following hematopoietic stem cell transplantation from unrelated donors., Data show that TGF-beta1 correlated with Bcl-xL and Bax in all colorectal cancers., Ribozyme to TGF-beta1 mRNA abrogates immunosuppressive effects of human colorectal adenocarcinoma HRT-18 cells in vitro and in vivo., HIF-1alpha and TGF-beta may have roles in breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment, a genetic association of TGF-beta1+915 Arg-->Pro at codon 25 polymorphism with Left ventricular hypertrophy in a Chinese hypertensive population., Both TGF-beta and activin signaling pathways are activated on allergen provocation in asthma. Activin-A may contribute to resolution of inflammation., These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate lung fibroblast proliferation and matrix production., TGFB1 single nucleotide polymorphisms were found to be associated with asthma at 5% level., TGF-beta is the dominant factor in promoting FAPalpha protein expression., A positive correlation was observed between the TGF-beta1, VEGF expression and IMD scores in infiltrating breast carcinoma, Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones., TGFbeta(1) activates EGFR via an H(2)O(2)-dependent mechanism, which subsequently leads to the activation of Erk(1/2)., TGF-beta(1) was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant)., Collectively, these data demonstrate that respiratory syncytial virus regulates the cell cycle through TGF-beta in order to enhance its replication., AR could mediate the TGF-beta1-induced FN production, which may associate with AP-1 activation., TGF-beta can override Myc activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1, loss or reduction of BRCA1 alters TGF-beta growth inhibiting activity via Smad3 during oxidative stress responses, observations of hyperexpression of TGF-beta1 in blacks suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population, Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma., No significant associations were found between FXIII-Val34Leu, FVII-323 del/ins, TGF-beta(1) (915G/C) gene polymorphisms and bronchopulmonary dysplasia phenotype in our population., IL-10 and TGF-beta1, as two important immunoregulatory mediators, participate in middle ear inflammatory response, especially in chronic course of OME in adults., The GG TGF-beta genotype may protect against acute rejection in older recipients during the first year after transplant., Since TGF-beta1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-beta1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes, we found the CC genotype of the transforming growth factor beta-1 gene to be associated with higher levels of total and specific IgE., transforming growth factor-Beta1 and IL-10 gene polymorphisms may affect host susceptibility to Behcets disease., TGFbeta1 stands as an important biomarker molecule for diabetic nephropathy and diabetic peripheral neuropathyscreening in our series., Expression of diffuse scleroderma TGFbeta-responsive signature stratifies patients into two major groups including a "diffuse-proliferation" intrinsic subset with higher modified Rodnan skin score and a higher likelihood of scleroderma lung disease, found that miR-21 expression was transiently increased after induction of adipogenic differentiation., p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity, Levels of IL-6 and TGF-beta1 have no predictive value for identifying patients with recurrent restenosis., we examine the literature to understand the role of TGF-beta in extracellular matrix turnover, in the development and progression of glaucoma, and in possible therapeutic strategies that can be devised by targeting the TGF-beta signaling pathways.[REVIEW], Data show that sHLA-Cw4 or sHLA-Cw3 alleles induced secretion of TGF-beta1 by ligation of stimulatory KIR2DS1 or KIR2DS2 isoforms., 4E-BP1 gene appears critical for TGFbeta/Smad4-mediated inhibition of cell proliferation., AR is a potent regulator of TGF-beta1 induced expression of FN in human mesangial cells., TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells, IL1, IL6, and TGFbeta contributed to human Th17 differentiation induced by LPS-activated dendritic cells, TGF-beta1 induced epithelial to mesenchymal transition in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids., HGF inhibited TGF-beta1 mRNA expression and reduced collagen III secretion., These findings identify the cyclic AMP pathway as a potent but differential and promoter-specific regulator of TGF-beta-mediated effects involved in extracellular matrix homeostasis., Activating variants in the TGFbeta-1 and VEGF gene promoters are associated with post-urinary tract infection renal scar formation in children., Results suggest that TGF-b1 -509C>T polymorphism is not associated with either an increased risk or progression of colorectal cancer., Our results suggest that decorin and TGF-beta1 may have a fundamental role in the pathogenesis of nephrogenic systemic fibrosis., These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways., We also observed greater expression of Col I and Col III mRNA in BDI patients and significant correlations between their expression and TGF-beta concentration and Smad7 mRNA expression., These results demonstrate how IL-18 activity is regulated by TNFalpha and TGF-beta1, and how IFNgamma production through regulation of IL-18 receptor and T-bet expression., beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads, Adenovirus E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-beta signalling., We show differences in expression of glycosaminoglycans are related to the over-expression of TGF-beta and TGF-betaRII in cultured fibroblasts from hereditary gingival fibromatosis and gingival fibroblasts treated with CyA., Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses, The gene expressions of TGF-beta1 and VEGF were significantly increased at the concentration of 0.1 mg/mL hyaluronic acidnd 0.1 mg/mL Hylan, respectively., -beta1 shRNAs could obviously inhibit the expression levels of TGF-beta1, CTGF, FN and cellular proliferation stimulated by HSA in HK2 cells., beta-catenin-a marker of early stage of colorectal carcinogenesis, as well as TGF-beta1 and HIF-1alpha appear to be devoid of prognostic significance for colorectal cancer in this study of disease free survival, Studies indicate that signaling pathways of STAT3, NOTCH, hedgehog and transforming growth factor-beta (TGFbeta), which are involved in stem cell renewal, differentiation, survival, and are commonly deregulated in HCC., data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes, TGF-beta1 -509T allele confers marginal protection for early stage 1B but risk for stage II of cervical cancer., This review examines the evidence for a neuroprotective role of TGF-beta1 in Alzheimer disease, and discusses the TGF-beta1 signaling pathway as a new pharmacological target of treatment [review], Our data provide evidence that TGF-beta signaling patterns vary by age and pathologic features of prognostic significance including ER expression., identified TGFbeta- responsive regulatory modules that can function in a cell type-specific fashion. Taken together, our results identify TGFbeta-dependent and -independent cis-regulatory modules of the C4ST-1 gene, The TGF-beta/NF-kappaB/PTEN cascade may be a critical pathway for pancreatic cancer cells to proliferate and metastasize, This preliminary study provides evidence that TGF-beta serum levels are significantly dependent on allergen exposure in allergic rhinitis., changes of TGF-beta1 could be correlated with radiation pneumonitis, The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas., A recurrent pathogenic R555W of TGFbetaI gene mutation is identified, which appears to be the predominant mutations causing granular corneal dystrophy (GCD) in different populations., TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer., TGF beta was correlated with the expression of Foxp3-mRNA and the frequency of CD4+CD25+Foxp3+ regulatory T cells in patients with chronic hepatitis B and chronic asymptomatic carriers., After 2 years of denervation, TGF-beta1 protein expression in endochylema of myofiber decreased, but after 3 years, no expression of TGF-beta1 protein in endochylema could be found in denervated posterior cricoarytenoid muscles., In primary IgA nephropathy, the T allele of the TGF-beta1 COD 10 C/T polymorphism seems to be associated with more severe histological lesions, higher renal TGF-beta1 mRNA levels and a worse prognosis., Application of miRNA did not down-regulate expression of the collagen I, but downregulated the collagen III gene., The ratio of Asporin to TGF-beta1 (transforming growth factor-beta1) mRNA in patients with severe cartilage damage was higher than that in osteoartritis patients with mild cartilage damage, Exploration of the association between genetic polymorphisms in the TGFB1 pathway and colorectal cancer susceptibility and clinical outcome., TGFB1 509 C/T polymorphism is associated with colorectal cancer in Asians., CTLA-4 blockade resulted in a significant decrease in HIV-specific TGF-beta positive and IL-10 positive CD8+ T cell responses, and a concomitant increase in HIV-specific IFN-gamma positive CD8+ T cell responses., A molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vascular smooth muscle cells phenotype., TGFbeta1 expression increases with severity of H.pylori- associated non-metaplastic atrophic gastritis., The expression of TGF-beta1 may be closely correlated with the invasion and metastasis of breast cancer., The breast cancer patients' relapse-free survival was shorter in the TGFbeta1-positive group than in the TGFbeta1 negative group., TGF-beta(1) decreased sGC and PKGI expression in pulmonary artery and aortic smooth muscle cells from adult rats and mice., TGF-beta1 serum levels are significantly lowered in patients with atrial fibrillation and chronic Helicobacter pylori infection., Studies indicate that hepatocyte-specific inhibition of the TGF-beta pathway prevents CCl4 induced liver injury., High levels of Smad3 are required for the tumor suppressor activities of TGF-beta, whereas lower levels are sufficient for the tumor promoting functions., lower blood levels in patients with ischemic heart disease, This is a small case-control study in Caucasians to investigate the role of the TGF-beta1 gene polymorphism T (29) C located in codon 10 in the genetic predisposition to Type 1 diabetes and diabetic nephropathy., A circulating TGF-beta1-mediated mechanism is involved, in both mice and humans, in the excessive deposition of extracellular matrix elements and hypertrophic growth of cardiomyocytes under pressure overload., TGF-beta1-800G>A polymorphism is not associated with cerebral infarction in Han population., The effect of isoflurane on caveolae formation in proximal tubule cells via transforming growth factor beta-1 release is reported., TGF-beta1 c.869T>C polymorphism may be a genetic risk factor for pre-eclampsia (PE) and intrauterine growth restriction-complicated PE., results provide evidence that TGF-beta1 up-regulates expressions of ABCA1, ABCG1 and SR-BI through the LXR alpha pathway in THP-1 macrophage-derived foam cells, MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes, In contrast with human normal bronchial tissue explants, lung parenchyma produces mesenchymal cells with a myofibroblastic phenotype by intrinsic mechanisms of TGF-beta activation in feed-forward manner., Matrine inhibits the TGFb1 signal transduction pathway in human lung fibroblast cells., Polymorphisms of TGF-beta1 gene do not appear to influence the incidence and clinical course of chronic hepatitis in children., Data suggest that serum TGF-beta(1) levels are potential biomarkers of HD development during the asymptomatic phase of the disease., The present results demonstrated that the TGF-beta3 rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects., There were no significant associations of TGFB1 single nucleotide polymorphisms with wheeze, asthma, allergic rhinitis, or eczema., Findings reveal a hyperactive TGFbeta-TGFbetaR-Smad2 signaling axis needed to maintain epigenetic silencing of critical EMT genes and breast cancer progression., This trial failed to confirm previously reported increases in fibrosis in rt-treated breast cancer patients with TGFB1 genotype - any increase greater than 1.36 can be excluded with 95% confidence., TGF-ss signaling, via Smad transcription factors, represents the major fibrogenic cytokine that is strongly elevated during progression of chronic liver diseases, including alcoholic liver disease., TNF-alpha enhances not only epithelial-mesenchymal transition but also cell contraction induced by TGF-beta1., High TGFB1 serum levels are associated with locally advanced non-small cell lung cancer., results demonstrate a critical role for the TGF-beta-FOXO pathway in the maintenance of leukemia-initiating cells, strengthening our understanding of the mechanisms that specifically maintain chronic myeloid leukemia LICs in vivo, JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts, TGF-beta1, TGF-beta2, and TGF-beta3 mRNAs were detected in both normal and pseudophakic bullous keratopathy (PBK) corneas., Meta-analysis suggests that the TGFB1 10P allele may be a low-penetrant risk factor for developing breast cancer., The effect of genetic polymorphisms in TGFbeta1/TGFbetaR1 on secreted TGFbeta1 levels in vitro could not be clarified., antiestrogen induces immunosuppression in the tumor microenvironment, through a TGFbeta-dependent mechanism that may contribute to the development of antiestrogen resistance in breast cancer., profiled the gene expression in mesenchymal stem cells in response to TGF-beta, and showed that TGF-beta induced Notch ligand Jagged 1 (JAG1) and smooth muscle cell markers., NKG2D downregulation was primarily caused by tumor-derived tumor growth factor-beta in glioblastoma patients, CXCR4 mRNA and protein expression were upregulated in TGF-beta1-treated MCF-7 cells., Meta-analysis suggests that the TGFB1 T29C polymorphism is not a low-penetrant risk factor for developing breast cancer., The expression of TGF-beta1, its receptor TGFbetaRII, and signaling proteins Smad4 and Smad7 was observed in the majority of colorectal cancer specimens., Fibrosis in radiotherapy-treated breast neoplasms tends to be higher in patients being polymorphic in TGFB1 when compared to patients with wildtype genotype., Data suggests a protective function of the frequent heterozygous C/T genotype against benign airway stenosis (BAS); alternatively, the C/C genotype might be a susceptibility factor for BAS., TGF-beta1 acts through activation of ERK1/2 and the small GTPase RhoA to promote plasma membrane trafficking of the hCNT3 protein., RGZ and CGZ inhibited profibrotic changes in TGF-beta1-stimulated A549 cells independently of inhibition of Smad phosphorylation., TGF-beta1 polymorphisms may serve as a susceptibility marker for tumor HPV16 status among patients with cell carcinoma of the oropharynx, CCN3 counter-regulates positive signals from TGF-beta and Wnt for fibrillin fibrillogenesis and profibrotic gene expression., TGF-beta1 and VEGF were less expressed in fresh frozen bone allografts than in regenerated alveolar bone., Data show that a significant increase in TAFs for VEGF, TGF-beta1, interleukins (IL-4, IL-10) and tumour necrosis factor alpha., increasedTGF-beta/Smad signaling activity by hyperplastic podocytes may lead to mesangial cell matrix overproduction and eventually to podocyte apoptosis and/or detachment, culminating in the development of glomerulosclerosis, the overexpression of TGFB1 and COLIA1 in Hashimoto's thyroiditis suggest that both genes are implicated in fibrogenetic processes during thyroiditis development., The expression rates of MMP-9, VEGF and TGFbeta-1 in poorly-differentiated follicular thyroid carcinoma were higher than those in well-differentiated follicular thyroid carcinoma., The polymorphism 869T/C in TGF-beta1 gene has a significant association with disease occurrence in COPD patients and the C allele might be a risk factor., TGFbeta1 is able to regulate CD133 expression through inhibition of DNMT1 and DNMT3beta expression and subsequent demethylation of promoter-1., These data indicated that Egfr gene activation by TGF-beta is involved in the differences in the expression of cellular matrix genes such as Fn., The onset of sepsis is related to differential TGFbeta-1 and IL-17 gene expression., analysis of the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist, Chronically damaged hepatocytes produce SERPINB3 and TGF-beta, and the anti-protease activity of the serpin might be implicated in TGF-beta1 induction., TGF-beta1 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation., analysis of proteomic changes in human bronchial epithelial cells in response to pro-inflammatory mediator leukotriene E4 and pro-remodelling factor TGF-beta1, generation of ROS by Nox4 mediates TGF-beta1-induced PAI-1 gene expression at least in part through oxidative modification and inhibition of MKP-1 leading to a sustained activation of JNK and p38 MAPKs., Demonstrate that TGFB1 -509 T allele was associated with a reduced risk to develop breast cancer and this allele appeared to act in an additive mode., High glucose stimulated mesenchymal stem cell proliferation thro