Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Fas ligand(FASLG) Fas ligand(FASLG) Related Genes Homo sapiens
CHROMOSOME 1,
CYTOBAND 1q23,
ENSEMBL_GENE_ID ENSG00000117560,
GENERIF_SUMMARY Mouse cells expressing human membrane-bound, but not soluble, Fas ligand induce inflammation in vivo., Expression of FasL gene in T cells of renal allograft recipients, Differential secretion of Fas ligand microvesicles during activation-induced death of T cells, Induction of FasL expression by adhesion of endometrial stromal cells to the extracellular matrix may take part in the development of immunotolerance by inducing apoptosis of cytotoxic T lymphocytes, Western blot analysis showed that butyrate increased Fas and Fas ligand levels in butyrate-induced apoptosis., Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas, A minimal region of the fasL promoter has been identified containing the transcription start site and a noncanonical c-Myc-binding element, which mediates fasL promoter repression by the activated vitamin D3 receptor in T lymphocytes., expression was found mainly on astrocytes and microglial cells; no significant difference between cases with and without pontosubicular neuron necrosis, Up-regulation in highly malignant multiple myeloma plasma cells negatively regulates erythroblast maturation; a major pathogenetic mechanism of anemia in multiple myeloma., evaluation of the FasL gene FASL on chromosome 1q23 as a candidate susceptibility gene for Type I diabetes, The results indicate that FasL inhibition by all-trans-RA involves a novel mechanism whereby the transcriptional function of NFAT is blocked., Fas/FasL pathway can be employed by monocytes/macrophages to induce VSMC apoptosis in the atherosclerotic lesions., upregulation of Fas by IFN-gamma in SNU-638 may accelerate the apoptosis pathway through the Fas and FasL interaction between gastric cancer cells and immune cells, physiological function of human sFasL is to delete the potentially auto-reactive "memory" lymphocytes, HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter, FasL protein is an important mediator of apoptosis., Differential expressions of Fas and Fas ligand in human placenta, Genetic polymorphisms of FasL (CD178) in human longevity, The endometrial cells expressed Fas and low levels of FasL, expressed during acute cellular rejection episodes after kidney transplantation, "trophoblast-cytokine-Fas/FasL triad" determines the ability of the Fas/FasL system to regulate trophoblast viability, Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles., Abnormal expression and function of Fas ligand of lachrymal glands and peripheral blood was found in Sjogren's syndrome patients with enlarged exocrine glands., findings support the hypothesis that the expression of FasL in normal ovary is hormonally sensitive, the role of Fas/Fas ligand (FasL) in tum orgenesis, immune escape, counterattack in colonic cancer, Regulation of fas ligand expression by IL-8 in human endometrium., inhibiton of CD95L expression by vitamin E, serum and peritoneal fluid of women with moderate to severe endometriosis contain elevated concentrations of soluble Fas ligand compared to women with minimal or mild endometriosis and women without endometriosis, tranduces, in synergy with non-cytotoxic anti-Fas monoclonal antibody (mAb), signals for apoptosis and nuclear translocation of the NF-kappaB (p65/p50) heterodimer, fas ligand is up-regulated in acute lung injury and the acute respiratory distress syndrome, The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms., T cells from systemic lupus erythematosus patients kill autologous monocytes through apoptotic pathways involving the ligand FasL., In transgenic mice, the human FASL promoter induces reporter expression in intestinal epithelial cells. Non-lymphoid FasL is expressed in response to peripheral T cell activation & regulates T cells that infiltrate peripheral tissues., Cleavage of FasL by MMP-7 occurs at the leucine residues in sequence "ELAELR" within the region between the transmembrane and trimerization domains. When this site is unavailable, a "SL," is cleaved. MMP-7 differentially processes murine and human FasL, homeostatic regulation of myelopoiesis in bone marrow is mediated via an autoregulatory feedback loop via the Fas-FasL pathway, A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics., Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to ligand-induced apoptosis, The Fas ligand may be involved in the apoptosis of astrocytic tumors, and the apoptotic index can be a useful parameter for assessing prognosis of astrocytic tumors., expression and function of fas ligand in human myeloid leukemia cells, Fas-L expression may be associated with the escape from of immunal surveillance., Fas system as an inducer of apoptosis in cutaneous leishmaniasis, To see if variants of the FasL gene played a role in Hashimoto's thyroiditis and Graves' disease, 2 FasL polymorphisms (C -843 T in the promoter, A IVS2nt-124 G in intron 2)were studied. No association was found., Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma, Through the high and sustained expression of FasL that is transcriptionally regulated, synovial gamma delta T cells of the V delta 1 subtype may efficiently lyse a wide variety of cell types at sites of inflammation., An AP-1 site located in the 5' untranslated region of the CD95L gene is required for TCR/CD3-mediated induction of the human CD95L promoter., Cross-talk between glioma cells and neutrophils through the Fas/FasL system stimulated expression of IL-6 and IL-8 in glioma cells, enhanced neutrophil viability, and stimulated cytokine production in neutrophils., JNK/p38 > c-Jun > Fas ligand > Fas pathway plays an important role in mediating cisplatin-induced apoptosis in ovarian cancer cells, expression and function in human urinary bladder transitional cell carcinomas; correlates with tumor progression, results showed that Fas and/or Fas-Ligand, Bcl-2, and tissue transglutaminase may be involved in apoptotic pathways leading to mucosal atrophy in children with coeliac disease, cytokine-induced trophoblast apoptosis is mediated in part by the FasL/Fas pathway, suggesting that cytokines promote sensitivity to Fas-mediated apoptosis, Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by this protein., apoptosis mediated by Fas-FasL and engagement of CTLA-4 are involved in modulation of the immune response in patients infected with Paracoccidioides brasiliensis, Longitudinal data indicate that FasL mRNA increases in peripheral blood mononuclear cells of multiple sclerosis (MS) patients, especially during the secondary progressive course, and is downregulated during clinical activity in relapsing remitting MS., Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in Alzheimer disease., ATG-induced apoptosis in T cells involves both Fas and TNF pathways and TNF-alpha is produced much earlier than Fas and FasL expression., Lethal cytokines, such as FasL, may contribute to peritoneal cell turnover and the loss of mesothelium in peritoneal dialysis., CTLA4-FasL fusion protein inhibits the primary mixed leukocyte reaction (MLR), induces specific hyporesponsiveness in the secondary MLR, and may potentially induce hyporesponsiveness by promoting both anergy and apoptosis of alloresponsive clones., Fas/Fas-L and Bcl-2 expression participate in regulation of apoptosis in extravillous trophoblast(EVT) along invasion to decidua. Increased apoptosis in invasive phenotype of EVT may be attributable to increased Fas and Fas-L and decreased Bcl-2., Fas ligand increases Kv1.3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux, cell shrinkage, and apoptosis, apoptosis by FasL-dependent ligation is not modulated by Bcl-2 in vivo, FasL is implicated in differentiation, growth, invasion and metastasis of gastric cancer by inducing apoptosis of infiltrating lymphocytes., Data suggest that increased intrathecal release of Fas, but not FasL or caspase 3, in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation., Levels in CSF are elevated in in neuro-Behcet's disease., induction of CD95/CD95L expression does not have a role in p53-induced apoptosis, Modulation of FasL by placental as well as maternal hormonal milieu induces apoptosis in decidual cells, glandular cells, and immune cells, facilitating trophoblast invasion and peritrophoblastic immunotolerance., Fas ligand is not constitutively expressed in normal peripheral blood or neoplastic B lymphocytes, Data show that Fas ligand is expressed on cytotoxic effector and memory cells, suggesting that the Fas/FasL system is involved in the inflammatory process observed in silicosis patients., Progesterone-induced apoptosis in immortalized normal and malignant HOSE cells involves enhanced expression of FASL., These results support a role for Egr-1, -2, and -3 in nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor., hepatitis C virus core protein plays a role in the induction of functional FasL in a hepatoblastoma cell line, Fas and Fas ligand expression in leukocytes during systemic inflammation, As brief as a >10-min exposure of human T cells to fibronectin-associated recombinant FasL induces T cell activation and potentiates proinflammatory capacities, e.g., adhesion to extracellular matrix, IFN-gamma secretion, and retention in inflamed areas., FasL blocks expression of CD28 at the transcriptional level, expression of CD95 in 15/17 human melanoma cell lines analysed, but complete lack of CD95 ligand (CD95L), expression levels in hepatocellular carcinoma, compard with HBxAg levels, activated langerhan's cells are capable of expressing CD95-L in a functional location, thus bearing the potential to exert tolerogenic capabilities against CD95-expressing T cells, This review considers the role of the FasL-Fas system as a double-edged sword in the central nervous system, NF-kappaB activation and FasL overexpression occur in PBMCs and atherosclerotic lesions of patients with carotid stenosis. The NF-kappaB-FasL pathway could be involved in the mechanisms underlying plaque instability in humans, The observed impact of FasL on adhesion and transendothelial migration provides evidence for novel biological functions of FasL., Fas engagement with Fas ligand induced activation of Akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis., Fas and FasL have roles in progression of breast cancer, CD95L derived from placenta acts systemically and is primary cause of liver damage in HELLP syndrome. Blocking CD95L can reduce liver cell apoptosis. Strategy may have therapeutic advantages., examined the correlation between injury of the hepatocytes and mRNA expression of FasL and perforin/granzyme B in liver tissue to investigate the roles of both the FasL and the perforin/granzyme B pathways in chronic hepatitis B, The sensitivity of FasL expressing tumor cells to lysis by cytotoxic T-cells was similar to that of FasL non-expressors, To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes., Results show that FasL in endometrial stromal cells in culture has a cyclic expression model, suggesting that there may be a regulation at the translation level., FASL secretion was analyzed in melanoma cells in culture. The secretion was associated with secretory vesicles upon melanoma activation with phytohemagglutonins or alpha-MSH., Significantly lower soluble form of fas is associated with bile duct carcinoma, fasL gene expression is induced by Hepatitis B virus X protein through enhancing transcriptional activity of Egr-2 and Egr-3, The function of endothelial FasL during atherosclerosis was studied in APOE(-) mice transgenic for human FasL. Overexpression of endothelial FasL is antiinflammatory and inhibits atherosclerosis under hypercholesterolemic conditions., The frequent expression and coexpression of Fas, FasL, and c-FLIP in urothelial carcinomas implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumors., addition of IL-12 might increase the efficacy of IL-2 immunotherapy by inhibition of the IL-10-mediated negative feed-back loop on IL-2-mediated sFasL release, CD95L, which is found elevated in many human cancer patients, has tumorigenic activities on human cancer cells, Cardiomyocyte necrosis and/or apoptosis via activated tumor necrosis factor (TNF) and the Fas/Fas ligand (FasL) system may be related to the development of ongoing myocardial damage., serum sFasL in biliary disease may be derived predominantly from activated immune cells and not from cancer cells, High levels of Max and stress-induced NFkappaB activation may result in elevated expression of Fas ligand in human lung cancer cells and possibly contribute to Fas ligand-associated immune escape mechanisms., FasL protein levels show that C57BL/10 cortical cultures are more resistant to death receptor-mediated apoptotic cell death as compared to C57BL/6 strain mice., FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha, CD95 and/or DR5 can induce apoptosis of CD40-activated chronic lymphocytic leukemia cells, Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis., sFasL may be involved in either induction of apoptosis or autoimmune diseases., upregulation of mesangial FasL may contribute to the glomerular inflammation in proliferative lupus nephritis, A lymphoproliferative disorder could be associated with mutation in this ligand., activation of p38 MAPK and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and TNFR1/TNFa expression, Fas and TRAIL play an important role in the H. pylori-mediated apoptosis of gastric epithelial cells., FasL is produced by and stored in the first trimester human syncytiotrophoblasts only and they lack surface membranal FasL., Supernatants from T cell blasts, pulse-stimulated with phytohemagglutinin contained FasL expressed on microvesicles ., Heart graft biopsies haveelevated FasL mRNA expression levels compared to the expression levels before and after acute rejection, results suggest that p21 and FasL gene activation is required for myeloid leukemia cell survival or maturation but not for cell death via Sp1 and NFkappaB as regulators of these genes, Effect of hibuscus polyphenol extracs in human gastric carcinoma cells is mediated via p53 signaling and p38 MAPK/FasL cascade pathway., The extracellular domains of FasL are sufficient to drive membrane FasL-induced formation of supramolecular Fas-FasL complexes, whereas soluble FasL-induced Fas aggregation is dependent on lipid rafts and the intracellular domain of Fas., Serum levels may be affected by insulin resistance, but is not an effective markers of silent myocardial ischemia in type 2 diabetes., FasL-mediated cytotoxicity is regulated by the FasL cytoplasmic tail, Cutaneous T cell lymphoma cells express functional FasL possibly contributing to bystander cytotoxicity within tumor infiltrates., The data suggest that lower expression of surface Fas, but higher levels of apoptosis-inhibiting sFas, contribute to the resistance of fibroblasts in lung fibrosis against apoptosis., Fas ligand is an apoptotic pathway of hepatocellular carcinoma cells., membrane-associated FasL is pro-apoptotic, whereas mFasL can be released from T lymphocytes., We evaluate a family with 4 of its 5 members harboring a mutation causing skipping of exon-6; ALPS in one male patient was caused by haploinsufficiency of membrane CD95 expression. Our data challenge the hypothesis that sCD95 causes autoimmunity, expression in oral and oropharyngeal squamous cell carcinomas is associated with tumor stage and grade, a linear pathway for Nef-induced FasL expression that encompasses p38 and AP-1 has been elucidated. Furthermore, chemical inhibition of the p38 pathway attenuates HIV-1-mediated bystander killing of CD8 cells in vitro, FASL polymorphisms contribute to susceptibility of lung cancer., Altered expression of Fas, FasL and PGF in trophoblasts of placenta influence the pathogenesis of pre-eclampsia., The expression of FasL is upregulated in colon cancer and the functionally expressed FasL can induce apoptosis of Fas-expressing T lymphocytes., Up-regulation of FasL expression plays an important role in invasive depth, histological classification and metastasis of gallbladder carcinoma., NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium, sFasL and matrilysin are expressed in seminal plasma and have a role in regulation of the function of the Fas system, The FasL expressed in human colon cancer cells may be regulated by endogenous factors in the microenvironment of the host and facilitate the escape of tumor cells from the host immune system., Data strongly indicate that an increment of soluble FAS/soluble FASL ratio after treatment could be an excellent marker of chemosensitivity in colorectal cancer., FASL expression on tumor-derived exosomes is required for induction of T-cell apoptosis, which appears to be a novel mechanism of tumor immune evasion., Plasma levels may be a marker for chronic hepatitis C infections., The downwards expression of Fas and the upwards expression of FasL in nasal polyps may inhibit the cellular apoptosis and the enhanced hyperplasia., During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of Fas ligand (FasL)., the trans-activation ability of Tat at the long terminal repeat does not correlate with T cell apoptosis but that the ability of Tat to up-regulate CD178 mRNA expression and induce apoptosis in T cells is critically dependent on the C terminus of Tat, Our data indicate an associaton between premature rupture of membranes and increased prevalence of neonatal AG genotype at -670 Fas promoter gene., results suggest that hepatitis C virus and Fas ligand play a key role in hepatocarcinogenesis, The combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy., the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL, These results indicate that aplastic anemia T cells are "preactivated", characterized by overexpression of FasL, especially intracellular FasL which can be stimulated to release in bioactive exosomes-bound form., Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression, and can counterattack the immune system via increasing FasL expression, FasL is recruited into lipid rafts for maximum Fas receptor contact and cell death-inducing potency, The FasLigand expression was up-regulated during acute kidney traft rejection episodes., Treatment of melanoma lines with soluble Fas ligand resulted in programmed cell death that was proportional to the pre-existing levels of surface Fas., FCH/SH3 proteins might play an important role for the subcellular distribution and lysosomal association of FasL., a novel fusion protein, designated scFvCD7, Localization to lipid rafts appears to be predominantly mediated by the characteristic cytoplasmic proline-rich domain of Fas ligand., thymosin beta-4 increases colon carcinoma apoptosis resistance triggered by FasL and apoptosis inhibitors by downregulating Fas and upregulating Survivin expression, Fas downregulation and a consequential increased resistance to FasL-triggered apoptosis resulting from upregulated MMP-7 in colorectal cancer cells could be a key mechanism for their escape from the immune surveillance, Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling., A marked up-regulation of TLR2 and Fas-FasL was detected in primary human gingival epithelial cells (HGEC) stimulated with heat-killed P. gingivalis, FAS and FASLG polymorphisms appear to jointly contribute to risk of bladder cancer in the southern Chinese population., Genetic variants in the FAS and FASLG gene may contribute to the etiology of melanoma in the general population, particularly in those with a low risk of sunlight-induced melanoma., FasL-associated adaptor protein Nck is involved in the actin-dependent transport of FasL-bearing secretory lysosomes to the mimunological synapse., chromatin remodeling is a primary event in the activation of TNFSF6 expression in primary and leukemia T cells, angiostatins K1-3, K1-4 and K1-4.5 mediate anti-angiogenesis in a process involvingp53, FasL, AKT and mRNA deregulation, Study concludes that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects., There may exist significant correlation between the expression of Fas/FasL and the development of the infantile hemangioma cells., findings show that deletion of primary thymocytes and Thy278 cells upon CD3 stimulation is considerably impaired by neutralizing CD95L antibody, The glucocorticoid receptor down-regulates fasL promoter by competing with NFkappaB for binding to the common response element., Fas/FasL-mediated signaling pathways play crucial roles in apoptotic disturbances of T cell subsets, especially of CD4+ T cells from systemic lupus erythematosus patients with active disease., Our findings identify a novel proinflammatory role of FasL in keratinocytes that is independent of caspase activity and is separable from apoptosis., most CD4(+)CD25(+)FOXP3(+) T cells found in cord blood are naive and exhibit low CD95 expression. Furthermore, most of these newborn T(regs) are not sensitive toward CD95L similar to naive T(regs) from adult individuals., Thus, m-CD95L expressing APC might be used in clinical settings to obtain tolerance induction in allogeneic transplantation systems or autoimmune diseases., sFas, sFas-L, and MMP-3, which were significantly elevated in sera of active untreated AOSD patients and paralleled disease activity, may be involved in the pathogenesis of this disease, Fas and FasL serum concentrations in patients coinfected with HIV and HCV indicate programmed cell death., Epithelial cell apoptosis and associated upregulation of Fas and apoptotic Fas pathway genes in epithelial cells of lungs with bleomycin-induced fibrosis., Thus, our work unveils that Fas ligand-mediated apoptosis induces scrambling of mitochondrial and secretory organelles via a global alteration of membrane traffic that is modulated by apical caspases., These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans., sFas concentrations are increased and sFasL are decreased in subjects at high cardiovascular risk, suggesting that these proteins may be novel markers of vascular injury., We found that signaling through CD62L up-regulated FasL., These results suggest that apoptosis triggered by the release of soluble FasL from invading trophoblasts contributes to the loss of smooth muscle from the walls of spiral arteries during pregnancy., Pemphigus vulgaris patient IgG works together with Fas-L and tumor necrosis factor-alpha in experimental cell cultures to induce acantholysis via basal cell shrinkage., The data demonstrated that HIV-1 Tat enhances C. parvum-induced cholangiocyte apoptosis via a paracrine-mediated, FasL-dependent mechanism., expression of FasL is upregulated in testes of patients with Sertoli cell-only syndrome & maturation arrest, suggesting that it may be associated with apoptotic elimination or altered maturation of Fas-expressing germ cells by activation of caspase-3., Significantly high Fas Ligand Protein is associated with aggressive NK-cell leukemia, interaction between membrane-bound hyaluronan and the cell surface CD44 was involved in the up-regulation of FasL expression on T cells and subsequent activation-induced cell death, phosphorylation and ubiquitin signals regulate the sorting of FasL to secretory lysosomes by controlling entry into multivesicular bodies, Treatment with oleandrin facilitated nuclear translocation of FKHR in human, but not murine cells by dephosphorylating Akt., These findings indicate that functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer., These findings suggest that ADAM10 represents an important molecular modulator of FasL-mediated cell death., results indicate that the -844C > T polymorphism is not related with the susceptibility to hepatitis C virus infection, the severity of liver damage and the progression of fibrosis in our cohort of Spanish patients, FasL CC genotype was found to increase the risk of ovarian carcinoma and a protective effect of the GGCT genotype was observed, Germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas., ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling, The frequent expression and coexpression of Fas, FasL and c-FLIP in colorectal carcinoma implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumours., The serum levels of soluble FASL were studied in patients with multiple organ failure with complicating peritonitis., Fas/FasL gene polymorphysms are possible that different mechanisms function in apoptosis balance in papillary thyroid cancer development, heterozygous human FasL mutation can dominantly interfere with normal FasL apoptotic function and lead to an ALPS phenotype, designated Type Ib, The amount of CaM recruited into the DISC was increased after Fas-stimulation, a finding confirmed by immunofluorescent analysis that demonstrated increased membrane co-localization of CaM and Fas upon Fas-stimulation., FasL expression was associated with higher tumour stage., Variants of human TRAIL (hTRAIL) and human CD95L (hCD95L), encompassing the TNF homology domain (THD), interact with the corresponding receptors and stimulate CD95 and TRAILR2 signaling after cross-linking., Abortion is associated with increased expression of FasL in decidual leukocytes., Serum level of FASL was determined during chemotherapy of lung neoplasms., The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk., FasL expression on APCs and phagocytosis of apoptotic T cells by FasL(+) KCs are indicators of rejection activity in human liver allografts., A higher expression of apoptotic molecules (Fas and FasL) on lymphocytes occurs before the onset of acute ischaemia and contributes to the plaque rupture and acute coronary syndrome., Allografted cells undergo Fas-mediated apoptosis induced by CD8+ T cells. Our objective was to prevent human keratinocytes from immunologically induced apoptosis by blocking the Fas ligand/Fas interaction., data demonstrated that the progression of TGCT is associated with the increased expression of FasL and a concomitant reduction of Fas, no significant associations found between Fas or FasL promoter polymorphism with hepatitis B virus clearance & HBeAg clearance, Paeoniflorin inhibits A549 cell proliferation via Fas/FasL apoptosic pathway., The expression of Fas ligand in the myocardium, as identified in HIV-positive patients, might increase the susceptibility to HAART-induced cardiomyopathy, The high numbers of tumor-infiltrating lymphocytes in tumors with high levels of microsatellite instability may be due to failure to up-regulate FasL., the risk of breast cancer may be elevated among women with polymorphisms in the FAS gene but not FAS ligand and detectable PAH-DNA adducts., regulation of FasL in SS patients with EEG may be due to transcriptional regulation, and the point mutation at - 259T/C in the FasL gene promoter region may lead to the down-regulation of FasL mRNA expression observed in SS patients with EEG., FasL and ICAM-1 expression in the tonsillar high endothelial venules contribute to idiopathic tonsillar hypertrophy and chronic hypertrophic tonsillitis., FAS-1377G > A, FAS-670A > G and FASL-844T > C gene polymorphisms may not be associated with the susceptibility of coal worker's pneumoconiosis in Han nationality., Tumor production of Fas-L may represent an attempt to destroy the host's lymphocytic reaction., CD95L-induced endosomal acidification, ceramide formation, and downstream events, such as p47(phox) phosphorylation, ROS formation, CD95 activation, and apoptosis., The increased apoptosis of peripheral blood lymphocytes from adult-onset Still's disease patients may be associated with the effect of IL-18 through up-regulation of FasL and p53 transcripts., lower level of soluble Fas may provide proper microenvironment for increased apoptosis of trabecular meshwork cells in primary open angle glaucoma, There was no significant association between an increased risk of cervical cancer and polymorphisms of the death pathway genes FAS and FASL., The death receptor pathway was activated by the expression of Fas ligand (FasL) or addition of TNF-related apoptosis-inducing ligand (TRAIL) in the presence or absence of proteasome inhibitors., Soluble Fas and soluble Fas ligand are increased in the joints of patients with rheumatoid arthritis and osteoarthritis., In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes., in HCV and HIV infections, the concentration of sFas, but not sFasL, in serum correlates with the concentration of ssDNA in liver tissue, The majority of memory CD8+ T cells in FasL transgenic mice display an effector memory phenotype in the long term, in comparison with the mainly central memory phenotype displayed by memory CD8+ T cells in wild type mice., FAS-1377, FAS-670 and FASL-844 polymorphisms are not susceptible factors of silicosis., primary SzS lymphocytes reveal frequent resistance to apoptosis induced by FasL and TRAIL, data suggest that there is a different regulation and function of the Fas/FasL system in early human pregnancies., Our findings suggest that the changes in the expression of apoptotic proteins (Fas/FasL and caspase 8) in the thyroid gland of patients with autoimmune Graves Disease and Hashimoto's thyroiditis reflect their involvemetn in the pathogenesis., Soluble Fas ligand plasma levels are associated with forearm reactive hyperemia in subjects with coronary artery disease, Overexpression of human FasL in pig islets inhibits CTL cytotoxic T cell xenocytotoxicity., FAS and FASL genotypes of the hosts are important determinants in the pathogenesis of gastric atrophy and intestinal metaplasia in H. pylori-infected individuals., Nucleus pulposus cells showed strong positive staining for FasLigand in all specimens examined. Quantitative examination demonstrated a significant decrease in FasL expression in the degenerated discs, placental FasL expression was significantly lower in abnormal pregnancies than in normal ones, These results show that the Fas/FasL-system mediated by caspase-3 activation plays a role in Clonorchis sinensis-infected hepatocyte apoptosis., Gastrin and somatostatin play important roles in the regulation and control of cell apoptosis in large intestinal carcinoma, and the mechanism may be directly related to the aberrant expression of Fas and Fas ligand., genetic variations in the death pathway genes FasL and CASP8 are involved in susceptibility to developing pancreatic cancer., N-terminal truncated product either with or without N-linked carbohydrate chain exhibited the specific binding activity toward soluble human Fas receptor extracellular domain-human IgG(1)-Fc domain fusion protein, Fas ligand appear to be differentially expressed on peripheral lymphocytes in the two opposite phenotypes of autoimmune thyroid disease., preventing autocrine CD95L signaling by c-FLIP facilitates T-cell effector function and an efficient immune response, in cultured endothelial cells, endothelial cell-derived microparticles and soluble Fas Ligand were significant factors in Ang-2(angiopoietin 2) elevation, The proportion of apoptotic CD8+ T cells was inversely correlated with serum levels of soluble Fas ligand in gastric cancer., Dendritic cells overexpressing CD95L promote tumor rejection involving neutrophil-mediated innate immunity and CD8(+) T cell-dependent adaptative immune responses, The SNP rs.3830150 A/G showed a significant strong inverse association with SJS/TEN. Analysis of the genotype pattern of SNPs rs.3830150 and rs.2639614 (rs.3830150 A/A-rs.2639614 G/G) also manifested a strong inverse association with SJS/TEN., To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis, SOD coenzyme can effectively regulate Fas/FasL signal transduction and block apoptosis of alveolar macrophages from pneumoconiosis patients., These data reveal that Grb2 facilitates the association of FasL with adaptin beta, and promotes sorting of FasL to the cell surface., Laryngocarcinoma cells could induce apoptosis of T lymphocytes through the Fas-FasL system., Immunohistochemistry using antibodies to determine the protein expression of Fas, Fas-L, Bax, Bcl-2, p53 and c-Myc in skin of venous ulcer patients., Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis., The expression rate of FasL on T cell subsets in idiopathic thrombocytopenic purpura patients was significantly increased., SBDS loss results in abnormal accumulation of Fas at the plasma membrane, where it sensitizes the cells to stimulation by Fas ligand, high expression in PBLs and injured synovia of rheumatoid arthritis patients, High FASL is associated with breast ductal carcinoma., several members of the PCH proteins interact with the proline-rich region of Fas ligand (FasL, CD95L), a key death factor in immune cells., the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1, FASLG -844C/T SNP may be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among Han Chinese men., Regulatory T cells (Treg) from head and neck cancer patients express CD95 ligand (CD95L), up-regulate CD95 and CD95L expression, and suppress CD8-positive responder cell proliferation by inducing Fas-mediated apoptosis., Determination of the FAS-L represents, together with the IL-10 concentration and the double negative CD8-CD4 T cell percentage, a reliable tool for the diagnosis of ALPS., active systemic lupus erythematosus is strongly associated with detectable serum levels of sFasL, Polymorphisms in the FASL is associated with early stage non-small cell lung cancer., A non-apoptotic role for Fas/FasL in erythropoiesis is reported., MMP7 is related to the acquisition of oxaliplatin-resistance and its inhibition restores drug sensitivity by increasing Fas receptor., FasL induced apoptosis and cell cycle arrest pituitary adenoma, The data presented here stress the importance of the Fas/FasL system for signal initiation via the TCR-CD3 complex and provide further arguments for a retrograde signaling capacity of FasL or a crucial role of Fas as a co-stimulatory molecule., the FASL rs763110 T allele has a possible protective effect on cancer risk, meta-analysis suggests that the FASLG -844T/C polymorphism is associated with cancer risk and the -844C allele is a low-penetrant risk factor for cancer development., The expression enhancement of intracellular FasL in rectal carcinoma in hypoxia can lead to accelerated proliferation and reduced apoptosis of cells., The distribution and regional location of Fas and FasL in gastric epithelial cells, gastric carcinoma cells, normal gastric stroma-infiltrating lymphoid cells and tumour-infiltrating lymphoid cells in human gastric carcinoma, was studied., high levels of soluble Fas ligand and tumor necrosis factor-alpha are associated with ALF, the Fas ligand (FasL)-activated apoptotic pathway mediates cytotoxicity in stem cells, In a human model of graft-versus-host disease, actively dividing subsets of alloreacting T cells are efficiently (>93%) reduced by soluble FasL treatment during mixed lymphocyte reactions (MLR)., Genetic polymorphisms of Fas and FasL in apoptotic pathway are associated with the risk of development of cervical carcinoma., FAS and FASLG polymorphisms may not contribute to risk of gastric cancer in the southern Chinese population., Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children., When the signal is mediated by full-length membrane-bound FasL, serine-threonine kinase RIP1 is likely a more integral part of physiological signaling through the Fas/CD95 receptor complex than previously recognized., Altogether, our data show that SMS1 is a novel caspase target that is functionally involved in the regulation of FasL-induced apoptosis., Downregulation of Fas expression in keratinocytes and lymphocytes of oral lichen planus specimens, together with upregulation of FasL, may serve as initial prognostic biomarker in oral cancer development., the importance of Fas/FasL-mediated apoptosis in lymph node homeostasis, Data demonstrate that XIAP antagonists in combination with Fas ligand (FasL) or the death receptor 5 (DR5) agonist antibody synergistically stimulate death in cancer cells and inhibit tumor growth., IVS2nt 124 G variant not associated with pre-eclampsia, Phospholipase A(2) (PLA(2)) from Naja naja atra venom increased Fas and FasL protein expression in human leukemia K562 cells, Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death, FasL expression may be prognostically significant in thyroid papillary microcarcinoma , suggesting that this counterattack could confer a survival advantage to the malignant cell during the course of cancer progression., 67LR induces FasL expression and cytotoxicity against Fas-sensitive Jurkat T cells in human cholangiocarcinoma cells through the phosphorylation of c-Myc on Ser-62 and the subsequent activation of the FasL promoter through the ERK pathway, HSF-1 associates with heat shock elements in a cooperative manner to mediate optimal FasL promoter activity, Quantitative RQ-PCR demonstrated that the expression of FasL mRNA in sperm from the varicocele group was higher than in the control group., Up-regulation of FasL expression and decrease of TIL apoptosis in Epstein-Barr virus-associated gastric carcinoma may facilitate the escape of tumor cells from the host immunosurveillance., Abnormal Fas and FasL expressions in gastric carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer., Psoralen and ultraviolet A upregulated Fas expression and downregulated FasL expression in NB4 leukemic cells, which induced apoptosis., FAS polymorphisms not significantly correlated with OSCC development or malignant potential of OL., Foxo3a is able to up-regulate FasL expression through down-regulating miR-21, Mutant PIK3CA interferes with apoptosis downstream of death receptor-signal complex, allowing caspase-8 activation without apoptosis. Cleavage of ROCK-1 by caspase-8 triggers amoeboid shape and invasiveness of HCT116 cells in response to TRAIL and CD95L., Acrolein triggers the death receptor pathway of apoptosis, causing elevation of Fas ligand (FasL) and translocation of adaptor protein Fas-associated death domain to the plasma membrane., the presence in individuals of two at-risk alleles of the three FAS/FASLG polymorphisms was associated with a lower risk of alopecia areata (adjusted OR 0.21; 95% CI 0.05-0.89) when compared with the presence of six at-risk alleles., down-regulating FasL expression and/or function in glial malignancies can enhance T-cell tumor infiltration and inhibit tumor growth, REVIEW, FASL polymorphisms are not associated with acute myeloid leukemia risk in Koreans., Results suggest a modestly increased risk for SPM after index SCCHN with FAS -670 A > G and FASLG -844 C > T polymorphisms and an even greater risk for SPM with multiple combined FAS and FASLG risk genotypes., Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95ligand)-mediated apoptosis of T cells, Functional polymorphism in cell death pathway FASL gene and risk of renal cell carcinoma are reported., FAS status and macrophage number and between FASL status and lymphocyte number in skin metastasis but not in primary lesions might point to diverse FAS/FASL interaction between neoplastic cells and macrophages in the different microenvironments, chronic disordered epithelial expression of MMP-7 in patients with asthma might increase mFasL cleavage and contribute to airway epithelial damage and inflammation., None of the polymorphisms analyzed influenced disease susceptibility and/or activity, but a high intake of total, saturated and monounsaturated fats and a higher ratio of n-6/n-3 polyunsaturated fatty acids, was associated with a more active phenotype., Results suggest that Jurkat cells might decrease the survival rates of A549 cells and enhanced its apoptosis and immune evasion partly via Fas/FasL pathway., FasL mRNA forms a complex with the RNA-binding protein HuR both in vitro and ex vivo., is a trend toward Fas-L being more prevalent in the epidermis of drug maculopapular rashes than in non-drug-induced maculopapular rashes, Polymorphisms of FASL is associated with nasopharyngeal carcinoma., Both Fas (cytoplasm and membrane) and FasL were significantly upregulated in syncytiotrophoblast of molar pregnancy., Individually expressed HSV-1 R1 (ICP6) shares, with HSV-2 R1, the ability to bind caspase-8 and to protect cells against death receptor-induced apoptosis., The FasL expression of human colon cancer cells may be regulated by endogenous interleukin-18 in the host microenvironment and enhance the liver colonization competence of colon cancer cells through induction of apoptosis in Fas-expressing hepatocytes., data indicate that membrane expression of FasL and its interaction with its counterpart may contribute to the inflammatory activation of macrophages during immune reactions or pathogenesis of chronic inflammatory diseases, results suggest that matrix metalloproteinase 9 (MMP-9) secreted by trophoblasts contributes to endothelial apoptosis via extracellular release of soluble Fas Ligand, This study compared concentrations of three cytokines (interferon-gamma and interleukin [IL]-2 and -4) and soluble Fas ligand in serum and pleural effusions from 36 patients with tuberculous pleurisy, 30 with malignant pleurisy and 30 healthy volunteers., Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription., Low expression of Fas and high expression of FasL are more often in colon tumor stage D and in liver metastasis, FasL activity in human and mouse lungs is determined by the structure of its stalk region, polymorphisms of FAS LG, FAS promoter and TP53 may have a role in increased risk of coronary artery disease progression, Post-translational modifications (S-nitrosylation of cysteine residues 199 and 304) in the cytoplasmic domain of Fas promotes fas ligand-mediated apoptosis in cancer cells., The processing of human Fas Lignad protein by ADAM10, but not by SPPL2a, counteracts FasL-mediated apoptosis., Celastrol can induce apoptosis of human non-small-cell lung cancer A549 cells through activation of both mitochondria- and Fas/FasL-mediated pathways., The aim of this study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed., soluble FasL positivity was associated with a favorable outcome in acute lymphoblastic leukemia patients., activation of FasL is dependent on glucuronoxylomannan interaction with FcgammaRIIB;results highlight a fast track to FasL up-regulation via FcgammaRIIB and assign to this receptor an anti-inflammatory role that also accounts for induced peripheral tolerance, This study determines if Fas/FasL regulates E. coli-induced human monocyte line U937 cell apoptosis., The levels of serum insulin, sFas were raised and sFas-L were decreased significantly in type 2 diabetes subjects than healthy., Increased apoptosis and the expression of FasL, Bax and caspase-3 in human lupus nephritis suggest that apoptosis might be induced through pathways of these proteins in the pathogenesis process., The activation of Fas/FasL pathway may play an important role in the K562 cell apoptosis induced by diallyl disulfide., Foxp3 negatively regulates CD95L expression in Tregs and demonstrates that Tregs are susceptible to homeostatic control by CD95 stimulation., The polymorphisms of FAS and FASL may be associated with the presence and severity of lumbar disc degeneration in Chinese Han population., FasL -844T/C polymorphism may predict survival and relapse in NSCLC., Downregulation of Fas receptor and up-regulation of Fas ligand appear to be an important feature of tobacco-related intraoral carcinoma., FASL 844T>C (rs763110)did not find any significant associations for all polymorphisms in relation to gastric cancer and high risk atrophic gastritis., No statistical association is found between the Fas, FasL and TRAIL polymorphisms and the risk of multiple sclerosis in Iranian patients., Apoptosis-related gene Fas (CD95) and FasL (CD178) polymorphisms in Iranian rheumatoid arthritis patients are more frequent than in controls, although this is not statistically significant., Fas and FasL mediated alveolar macrophage apoptosis in human silicosis., Functional polymorphisms in the apoptotic pathway genes FAS and FASL may significantly contribute to the occurrence of gastric cardia adenocarcinoma., Administration of prostaglandin I2 has proapoptotic effects in pulmonary artery smooth cells, resulting in Fas ligand upregulation., Abnormal expression of Fas/FasL and increased apoptosis of tumor infiltrating dendritic cells in endometrioid adenocarcinoma may lead to tumor immune escape., FasL and HO-1 overexpression have beneficial effects in pancreatic islet transplantation, Data indicate that lower values of neutrophil/lymphocyte ratio (NLR) and Fas ligand (FasL) expression in late-recurrence compared with other metastatic timings suggest strong host immune activity, and may imply relatively long survival., High expression of FasL is associated with ovarian epithelial tumors., Report high expression of Fas ligand on cord blood dendritic cells which may reduce severity of graft-versus-host disease after cord blood transplantation., primary liver disease could influence the pre-transplantation levels of sCD86 and sCD95L. High pre-transplantation serum levels of sCD86 could favor the development of episodes of acute rejection., CD95-ligand may have a role in recurrence in patients with synchronous colorectal liver metastases, Apoptosis markers sFas, FasL or sFas/FasL ratio are associated with high sequential organ failure assessment score (SOFA) in bacteremia., Results indicate that FAS-FASL-CASP8 polymorphisms contributed to a reduced risk of childhood lymphoblastic leukemia (ALL) in Chinese population., AMPK regulates expression of FASL and COX-2 via the protein kinase C theta - dependent pathway in activated Jurkat cells., We provide the first direct evidence that massive liver cell death can be caused by Fas/Fas ligand (FasL) interaction provided by natural killer cells activated by dendritic cells., Our results suggest that the chromatinization status of the FasL promoter may function as a molecular switch, controlling cAMP and glucocorticoid responsiveness in t-cells, the Fas and Fas-L mRNA expression levels in BGSCs were lower compared to those in primary cultured glioma cells, NK cell induction of hepatic stellate cell apoptosis in HCV infection was contact dependent and could partly be blocked by antibodies specific for TRAIL, NKG2D and FasL., Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo, Fas has a pro-apoptotic role in photoreceptors. Under light stress, soluble and membrane-bound FasL can bind to Fas, inducing apoptosis via a paracrine mechanism, Fas ligand enhances malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts., In summary, the Fas/FasL pathway involved in alveolar epithelial cell apoptosis could be important in the pathogenesis of seawater-induced acute lung injury, meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk., Data indicate that oligomerization of CD95L has no major effect on CD95 occupancy., Dexamethasone upregulates the apoptotic gene expression of Fas/FasL in human articular chondrocytes., levels of serum Fas and FasL in schizophrenic patients, Plasma concentrations of Fas receptors and Fas ligands tend to be higher in HIV-positive patients., the FASL-844 CC genotype and C allele seem to be associated with a good prognosis in patients with diagnosis age = 50 years., The aberrant expression of corticotropin-releasing hormone in pre-eclampsia may activate the FasL-positive decidual macrophages, impair the physiological turnover of extravillous trophoblasts, and eventually disturb placentation., Non-small-cell lung cancer patients carrying XRCC1 Arg194Arg, FAS-1377GG, and FASL-844T allele displayed completely no response to platinum based drugs., presence of strong myoepithelial expression of Fas and simultaneous cytoplasmic and nuclear expression of FasL in epithelial cells could be suggestive as an early predictive factor or signal for onset of breast cancer, Genetic polymorphisms of .... fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease., These experiments further define the molecular mechanism of estrogen's bone-protective effects by inducing osteoclast apoptosis through upregulation of MMP3 and FasL cleavage., data strongly indicate that the inhibition of ceramide conversion to complex sphingolipids by D609 is accompanied by an enhancement of FasL-induced caspase-dependent and -independent cell death in T lymphocytes., during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis., findings suggest that the FasL -843C/T and VDR FokI gene polymorphisms are associated with type 1 diabetes in the Agean region of Turkey., FasL was expressed more strongly in moderately and poorly differentiated cutaneous squamous cell carcinoma tumors., In keratoconus, corneal epithelium with higher expression of FasL may evoke apoptosis in keratocytes, while neprilysin could prevent possible rescue of keratocytes from apoptosis., study demonstrates that the HeLa cervical cancer cell line expresses CRH; additionally, CRH was shown to induce FasL expression, FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor., Decreased Fas/FasL signaling mediates miR-21-induced chemoresistance in pancreatic cancer., Soluble CD95L serum levels are elevated during the subacute and intermediate phases of spinal cord injury., FasL and ADAM10 play an important role in the production of pro-inflammatory cytokines coming from interaction of the intervertebral nucleus pulposus cells and macrophages in co-culture, Functional polymorphisms in the Fas and FasL genes may be involved in epithelial ovarian cancer development and progression in northern Chinese women., Suggest the involvement of the CD95/CD95L pathway in phagocytosis-induced cell death of monocytes and provide evidence that diminished CD95L secretion by cord blood monocytes may result in prolonged activation of neonatal immune effector cells., expression of Survivin was negatively correlated with that of Fas (r = -0.517, p < 0.01), but positively correlated with that of FasL (r = 0.381, p < 0.01) in tissues of cervical cancer, In 101 rheumatoid arthritis patients vs 105 controls, there was no significant difference in Fas-670 A/G genotype distribution or allele frequency, there was a correlation with anti-CCP antibody synthesis & anemia., Tregs, but not Th17 cells, become apoptotic through Fas/FasL pathway, which contributed to reduction of Tregs leading to an imbalance between Th17 and Treg cells., genotype distributions and allele frequencies of fas ligand did not differ between patients with knee osteoarthritis and controls., High serum FasL expression is associated with hepatic fibrosis in Nonalcoholic Fatty Liver Disease., Suggest that the FAS-L gene polymorphism is associated with RPL in Brazilian women and that these women also have impaired FAS-FAS-L systems due to abnormal FAS-L expression., In esophageal squamous cell carcinoma miR-21 expression is increased. miR-21 down-regulation inhibits cell growth, invasion and induces cells to apoptosis by targeting FASL, TIMP3 and RECK genes., The results suggest that FasL is a mediator of immune privilege in oral squamous cell carcinoma and may serve as a marker for predicting malignant change in oral tissues., Data indicate that FAS-1377G/A and FASLG-844 T/C genotypes are likely to play a substantial role in HBV infection, and FAS-670 polymorphism is associated with chronic HBV infection, while FASLG IVS2nt-124 A/G polymorphism is not., This is the first study presenting sFas and FasL concentrations in early second-trimester amniotic fluid in appropriate for gestational age , small for gestational age, and large for gestational age fetuses., FASL-844T>C polymorphism is associated with risk of laryngeal and hypopharyngeal squamous cell carcinoma., there were no associations of CD95 A670G and CD95L T844C polymorphisms with gastric cancer, FasL serum levels are not markedly affected in patients with familial Mediterranean fever (FMF) and cannot be used as a supportive marker to differentiate FMF attacks from attack-free periods., Semiquantitative analysis of the pattern and distribution of the Fas antigen and Fas Ligand as indicators for hepatic apoptosis was studied and assessed., Fas ligand correlates with the documented degree of atrial apoptosis and atrial fibrosis in right atrial appendage tissue after cardiac surgery., Silencing of decoy receptor 3 (DcR3) expression by siRNA in pancreatic carcinoma cells induces Fas ligand-mediated apoptosis in vitro and in vivo., FAS ligand levels are biomarkers for patients with lymphoproliferation and autoimmune cytopenia., These findings indicate that sFas and sFasL might play a role in intervertebral disc degeneration., results provide the proof of concept for an optimization of FasL-based chimeric proteins for a therapeutic use, A prometastatic function for metalloprotease-cleaved CD95L in triple-negative breast cancer., the FASL polymorphism rs763110 is associated with a significantly reduced risk of cancer, especially in Asian populations., There is an association of the FAS and FASL gene variants in the promoter regions with primary brain tumors in the Turkish population., Insulin-sensitive obese individuals had significantly lower Fas and FasL expression than insulin-resistant obese individuals., FasL and TRAIL are clustered on the exosomal membrane as oligomerized aggregates ready to form death-inducing signaling complex., FasL-Fas network might play an important role in the molecular mechanisms of angiogenesis prevention of human intervertebral discs., observed that the FAS-1377G/A and FASL-844C/T polymorphisms were associated with breast cancer risk in Chinese but not whites, Aqueous humor concentrations of the cytokines (IL-1 alpha, IL-1 beta, IL-6, FasL, and TNF- alpha) in patients with open angle glaucoma, were measured using multiplex bead analysis., In the title., First evidence that full length FasL and FasL fragments display selectivity regarding their association with intracellular binding partners., Identify a novel mechanism of interaction between TGF-beta1 and miR-21 in the regulation of FasL protein, which is involved in keloid formation., Polymorphisms in FAS and FASL genes are not associated with HBV infection in the Brazilian Amazon region., Fas 1377G > A polymorphism and FasL 844 T > C polymorphism are both not associated with susceptibility to cervical cancer, there is an association between FASLG T844C polymorphism and susceptibility to breast cancer, especially in Asians, We investigated the association between common polymorphisms in the genes for FAS and FASL and the risk of late side effects after radiotherapy for prostate cancer., FasL -844 CC combined with the Fas -1377 G allele is a protective factor against ESCC., Survival of porcine fibroblasts enhanced by human FasL and dexamethasone-treated human dendritic cells in vitro., In CAD patients, FasL in plasma is associated with both apoptotic susceptibility of NK cells and dynamic changes in circulating NK cells. FASL is a soluble marker with possible atheroprotective effects., Fas-Fas-ligand signal transduction could be inhibited, especially at the stage of caspase-8 activation, thereby establishing a major mechanism for evasion of apoptosis by these tumors, Carriers of the Fas-1377A and the FasL -844C are more susceptible to the majority of cancers than non-carriers. [Meta-analysis], meta-analysis suggests that CD95L polymorphism may not be a risk factor contributing to cervical cancer development, Functional NK cell repertoires are maintained through IL-2Ralpha and Fas ligand., data indicated a possible linkage between the FAS and FASLG genes and idiopathic azoospermia, FAS A-670G polymorphism is associated with a higher risk for Pre-eclampsia (PE). There was no association between FAS Ligand C-844T polymorphism and PE., High serum Fas ligand levels are associated with disease progression in multiple myeloma., Fas/FasL interaction mediates keratinocyte death in sunitinib-induced hand-foot skin reaction, FAS-1377 G and FASL-844 T alleles may be used as low-penetrant risk factors for bladder cancer development in a Turkish population., miR-21 is involved in MNNG-induced gastric carcinogenesis in vivo and in vitro via FASLG/BTG2 pathway., Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells., Fas/FasL signaling pathway of the lung microenvironment participates in the development of osteosarcoma lung metastases. (Review), This work reveals a novel mechanism of memory B cell apoptosis mediated by LPS and HIV through the Fas/FasL pathway., soluble apoptosis markers as sFas-L, Caspase-9, Caspase-8 and sCD153 were significantly higher in stage III obesity patients compared obese patients without food allergy, Soluble and membrane bound FASL have distinct roles in rheumatoid arthritis fibroblast-like synoviocytes, with sFASL promoting cell proliferation, and mFASL promoting apoptosis., The T/T genotype and the T allele of the c.-844T>C polymorphism were associated with increased occurrence of keratoconus, while the C allele was associated with decreased keratoconus occurrence., Up-regulation of Fas-L and cell surface localization of FAS induced by PEDF is mediated by p53., High Fas expression promotes chemoresistance in gastrointestinal cancer by up-regulating P-glycoprotein., Death induced by CD95R/L elimination (DICE) and CD95-mediated apoptosis have opposing roles in eliminating cancer stem cells (CSCs)and non-CSCs., Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation., MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG., data show that the expression of CD200R, CD95 and CD95L was influenced by cardiac surgery and imply the role of these membrane molecules in cell regulation-inhibition and apoptosis following cardiac surgery., data indicate upregulation of the sFas/sFasL system in psoriatic patients., these findings provide novel experimental evidences supporting that VC or/and VE could reduce p,p'-DDT-induced cytotoxicity of HL-7702 cells via the ROS-mediated mitochondrial pathway and NF-kappaB/FasL pathway., Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway., High levels of sFasL is associated with rheumatoid arthritis., FasL -844 SNP is associated with the susceptibility of pulmonary AD in age <60 years people. Fas -1377 SNP may modify the association of FasL -844 SNP with the risk of pulmonary adenocarcinoma., that both ADAM10 and ADAM17 are associated with FasL-containing secretory lysosomes., FASL -844 T > C promoter single nucleotide polymorphism is associated with oral cancers., Th1 cells express high level of FAS-ligand (FASL), which interacts with FAS and leads to caspases' cleavage and ultimately to cell death., Findings suggest that FAS rs1800682 and FASLG rs763110 variants modulate the risk of recurrence of squamous cell carcinoma of the oropharynx, particularly in patients with HPV16-positive tumors., There was no correlation between TGF-beta1 levels and HBV load, but there is a positive correlation between sFas levels and HBV load., DcR3 enhances ERK1/2 phosphorylation and opposes FasL signaling in pancreatic cancer cells, Membrane-bound FasL mediates platelets-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces platelets-induced apoptosis., Case Reports, The expression of Ki67 and FasL is closely related to the occurrence and development of cervical carcinoma., Fas Ligand Deficiency Impairs Tumor Immunity by Promoting an Accumulation of Monocytic Myeloid-Derived Suppressor Cells, In patients with either Crohn's disease or ulcerative colitis, the extent of endothelial FasL expression was elevated in the submucosa and associated with an elevated number of lymphoid follicles., FASL expression is an independent marker for earlier disease relapse and disease-specific death in oral squamous cell carcinoma., No association has been found between FASL promoter polymorphisms and predisposition to HIV infection., These data indicate that Epstein-Barr virus exosomes derived from EBV-infected cells are taken up by non-infected cells and induce apoptosis via the extrinsic pathway, and that exosomes trigger apoptosis through the FasL pathway., Data suggest Faim2/LFG (lifeguard protein) protects against FasL-/Fas ligand-induced apoptosis by down-regulating calcium release from endoplasmic reticulum in cortical neurons., Fas/FasL system and downstream activation of caspases are important mediators of apoptosis and may be involved in the pathogenesis of pulmonary edema in severe P. falciparum malaria patients., Abnormal Fas/FasL expression in gastric cardia carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer., No mutation or variation could be found in FASL in patients or controls., These results suggested that FAS/FASL polymorphisms might significantly modify SPM risk among patients with SCCHN in a tumor site-specific manner., FASL, granzyme B, and cytochrome c blood expression reflects breast cancer progression and response to therapy. (Review),
OFFICIAL_GENE_SYMBOL FASLG,
OMIM_DISEASE Lung cancer, susceptibility to, Autoimmune lymphoproliferative syndrome, type IB,
SP_COMMENT disease:Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly., function:Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects., online information:FAS-ligand entry, online information:FASLG mutation db, PTM:N-glycosylated., PTM:The soluble form derives from the membrane form by proteolytic processing., similarity:Belongs to the tumor necrosis factor family., subcellular location:May be released into the extracellular fluid, probably by cleavage form the cell surface., subunit:Homotrimer.,