Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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Fas cell surface death receptor(FAS) Fas cell surface death receptor(FAS) Related Genes Homo sapiens
CYTOBAND 10q24.1,
GENERIF_SUMMARY A significant correlation with differentiation status of the tumor was found for the p53 aberration but not for CD95 expression., Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling, its polymorphism may contributes to the pathogenesis of spondyloarthropathy, induction of gene expression by doxorubicin in endothelial cells through a p53-dependent mechanism, Soluble Fas antigen (sFAS) in the serum from patients with adrenal tumors., Butyrate induced apoptosis via the Fas/Fas L system and potentiated Fas-triggered apoptosis in MCF-7 cells., Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas, Cytochrome c release upon Fas receptor activation, expression was significantly increased in neonates with pontosubicular neuron necrosis, FAS germline mutations have been associated with the development of autoimmune lymphoproliferative syndrome (ALPS)., Participation of Fas-mediated apoptotic pathway in KB, a human head and neck squamous cell carcinoma cell line, after irradiation, expression associated with apoptosis in sun-exposed keratinocytes, myelodysplastic syndrome CD34(+)-derived erythroid progenitors underwent abnormal Fas-dependent apoptosis during differentiation that could be responsible for the impaired erythropoiesis., Met sequesters Fas, preventing apoptosis., Overexpression of the mouse Fas gene in human Hep3B hepatoma cells overcomes their resistance to Fas-mediated apoptosis., Plasma FasL levels were significantly high in patients with grade II - IV graft-versus-host disease., Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia, upregulation of Fas by IFN-gamma in SNU-638 may accelerate the apoptosis pathway through the Fas and FasL interaction between gastric cancer cells and immune cells, Decreased function of Fas in patients displaying delayed progression of HIV-induced immune deficiency, Mature dendritic cells are protected from Fas/CD95-mediated apoptosis by upregulation of Bcl-X(L)., Fas engagement increases expression of interleukin-6 in human glioma cells., Differential expressions of Fas and Fas ligand in human placenta, Genetic polymorphisms of Fas (CD95) in human longevity, HLA class II signals sensitize B lymphocytes to apoptosis via CD95, Endotoxin-induced lymphopenia was constituted by cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)), Our results indicate that Fas-mediated apoptosis is important for endometrial cycling and suggest that dysregulation of the Fas/FasL interactions may have an important role in the development of endometrial cancer., "trophoblast-cytokine-Fas/FasL triad" determines the ability of the Fas/FasL system to regulate trophoblast viability, data suggest that disruption of the cytoskeleton causes apoptosis via activation of CD95 and enhances UV-induced apoptosis, possibly via aiding receptor clustering, Recipient gene polymorphism and acute renal allograft rejection, alteration associated with nodal metastasis in non-small cell lung cancer, Data indicate that the apoptosis program in T cells includes the shedding/secretion of different forms of Fas to spread a death signal., Fas defects may play a role in the pathogenesis of mycosis fungoides, FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication., Fas promoter -670A/G polymorphism was significantly associated with systemic lupus erythematosus (SLE), suggesting a possibility that Fas promoter contributes, at least in part, to the pathogenesis of SLE, These results suggest that Fas is involved in neuronal apoptosis in the developing human brain., Frequent mutations of Fas gene in nasal NK/T cell lymphoma, Interferon-gamma increases its expression in B-leukemia cells., the death effector domain of FADD is involved in interaction with Fas., CCR5 mediates Fas- and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells, the role of Fas/Fas ligand (FasL) in tum orgenesis, immune escape, counterattack in colonic cancer, two novel mutations in the Fas receptor gene TNFRSF6 in autoimmune lymphoproliferative syndrome, 7 of the 13 melanoma cell lines were found to have impaired Fas signalling. Taken together, our results indicate that downregulation of Fas expression and resistance to Fas-mediated apoptosis are frequent in melanoma., suppression of fas-induced apoptotic signal transduction by thymidine phosphorylase, a role of Fas gene mutations in the pathogenesis of testicular germ cell tumors, The apoptotic episodes surrounding the earlier stage of DC differentiation appeared to be mediated by Fas. In contrast, a Fas independent pathway is probably responsible for the apoptotic events associated with terminally differentiated DC., In the case of Fas-mediated apoptosis, when we transiently introduced these hybrid-ribozyme libraries into Fas-expressing HeLa cells, we were able to isolate surviving clones that were resistant to or exhibited a delay in Fas-mediated apoptosis, DNA damage, death receptor (CD95) activation and ROS formation contribute to UVB-induced apoptosis in an essential and independent way., signals to mitochondria via FADD, caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid compared to TRAIL receptor 2, Caspase-10 is recruited to and activated at the native CD95 death-inducing signalling complex in a FADD-dependent manner., Stimulation of CD95 in the presence of caspase inhibitors induces necrosis and expression of various proinflammatory cytokines in primary T lymphocytes, such as TNF-alpha, IFN-gamma and granulocyte/macrophage colony-stimulating factor., molecular model of a conformational alteration of a mutated extracellular domain of Fas antigen in an adult T cell leukemia cell line, Review. Fas introduces apoptosis-inducing signals into cells. It is implicated in peripheral lymphocyte regulation, elimination of autoreactive cells, tumors & virus-infected cells, & tissue disruption in autoimmune disease & fulminant hepatitis., Glutathione peroxidase-1 protects from apoptosis induced by this antigen, IFN-gamma enhanced constitutive CD95 expression. Coincubation with anti-CD95 monoclonal antibody induced apoptosis, Fas resistance of leukemic eosinophils to NF-kappa B activation results from Fas ligation itself and can be negated by inhibition of the nuclear translocation of p65/p50., Immunohistochemical expression of this protein in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals., Fas induces alpha(v)beta(8) integrin in cell migration, Tyrosine-based sorting signal in adenovirus RID plays a role in RID's ability to down-regulate FAS and inhibit apoptosis, Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction, Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities., A novel signaling mechanism shows synergy with anti-CD95 monoclonal antibodies for apoptosis and NF-kappaB nuclear translocation., that H(2)O(2) induces Fas upregulation by promoting cytoplasmic transport of Fas to the cell surface in human airway epithelial cells, and that the activation of the poly(ADP-ribose) polymerase-p53 pathway may be involved in this mechanism., fas Receptors are up-regulated in acute lung injury and the acute respiratory distress syndrome, Delayed elevation of ceramide is proposed to promote necrosis in Fas-stimulated cells where caspase-8 activation was insufficient to trigger caspase-3-dependent apoptosis, Ox-LDL dose-dependently up-regulated cell surface Fas expression, determining the degree of apoptosis., the lower expression of Fas in urinary malignant cell lines than that in normal cells might be the reason for occurrence and progression of urinary malignant tumors., Data suggest that frequent Fas gene mutations in nasal natural killer (NK)/T-cell lymphoma (NL) can result in resistance to apoptosis and may contribute to the pathogenesis of NL by adding to the tumor immune privilege., homeostatic regulation of myelopoiesis in bone marrow is mediated via an autoregulatory feedback loop via the Fas-FasL pathway, A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics., induced il-8 production is activated by activation o the p38 MAPK and ERK1/2 pathways in colonic epithelial cells, Further evidence for role of a promoter polymorphism in the TNFRSF6 gene in genetic predisposition to Alzheimer disease., The Fas antigen may be involved in the apoptosis of astrocytic tumors, and the apoptotic index can be a useful parameter for assessing prognosis of astrocytic tumors., Bcl-2 may be involved in protecting against CD95-mediated apoptosis of cord blood CD34(+) cell., The Fas genotype may not appear to be a risk factor for stroke in Korean stroke patients., The Fas expression is positively correlated with the different degrees of differentiation, CD95 gene mutations play little if any role in the generation of the pool of plasmablasts from systemic lupus erythematosus patients, Fas system as an inducer of apoptosis in cutaneous leishmaniasis, Over-expression of the splice variant Luca-15 inhibited CD95-mediated apoptosis in CEM-C7 T-cells., Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma, sFas promotes a pro-apoptogen effect, which would explain the high susceptibility to apoptosis in active lupus, and that the apoptosis program itself includes release of sFas to spread the death signal., Dysfunction of the Fas apoptotic signaling pathway in persistent polyclonal B-cell lymphocytosis., Vitamin C inhibition of FAS-mediated apoptosis was associated with reduced activity of caspase-3, -8, and -10, as well as diminished levels of ROS and preservation of mitochondrial membrane integrity., Cross-talk between glioma cells and neutrophils through the Fas/FasL system stimulated expression of IL-6 and IL-8 in glioma cells, enhanced neutrophil viability, and stimulated cytokine production in neutrophils., Fas-induced apoptosis of myeloid leukemia cells is restricted to G1 phase of the cell cycle and can be increased by interferon, IL-18 and TNF-alpha function both as apoptosis-promoting factors and as apoptosis-inhibiting factors in acute liver failure, results showed that Fas and/or Fas-Ligand, Bcl-2, and tissue transglutaminase may be involved in apoptotic pathways leading to mucosal atrophy in children with coeliac disease, maternal serum sFas antigen decreased significantly in the first trimester of pregnancy and at term, possibly affecting immune tolerance and apoptosis for rupture of membranes; amniotic fluid sFas decreased at term compared with the second trimester, CD95 apoptotic function is regulated by SODD/BAG4, apoptosis mediated by Fas-FasL and engagement of CTLA-4 are involved in modulation of the immune response in patients infected with Paracoccidioides brasiliensis, Fas is inhibited by FAP-1 in tumor cells, Longitudinally obtained data indicate that Fas is upregulated in peripheral blood mononuclear cells of multiple sclerosis patients, especially during secondary progressive course; in relapsing remitting patients Fas levels increase even more dynamically., Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in Alzheimer disease., Increased expression of Fas antigen on CD4+ subset and increased serum sFas level are valuable markers of clinical activity in multiple sclerosis., Expression of a functional Fas death receptor by human foetal motoneurons., ATG-induced apoptosis in T cells involves both Fas and TNF pathways and TNF-alpha is produced much earlier than Fas and FasL expression., upregulation of expression by p53 upon genotoxic treatment in human breast tumor cells, Fas-induced monocyte cytokine responses are associated with monocyte apoptosis, nuclear translocation of NF-kappa B, and cytokine gene expression and are blocked by caspase inhibition but not by inhibition of IL-1beta signaling., Fas/Fas-L and Bcl-2 expression participate in regulation of apoptosis in extravillous trophoblast(EVT) along invasion to decidua. Increased apoptosis in invasive phenotype of EVT may be attributable to increased Fas and Fas-L and decreased Bcl-2., increased expression of soluble Fas in pleural effusion associated with lung cancer, in B cells, Gadd45 beta is induced by CD40 through a mechanism that requires NF-kappa B and this induction suppresses Fas-mediated killing, oligomerization/depolymerization of soluble Fas antigen can regulate its activity, Data suggest that increased intrathecal release of Fas, but not FasL or caspase 3, in the cerebrospinal fluid of infants with hydrocephalus may serve as an indicator of brain injury from progressive ventricular dilatation., While short-term activated T cells (two to five rounds of stimulation) are CD95 sensitive and susceptible to activation-induced cell death (AICD), T cells stimulated more than eight times acquire constitutive CD95 resistance and exhibit reduced AICD., CD95 was expressed at a higher level on CD45RA+ peripheral T-cells in the fetus than in the adult., Fas stimulation may contribute to hepatocellular carcinoma cell survival or proliferation, induction of CD95/CD95L expression does not have a role in p53-induced apoptosis, possible role of FAS mutations upon higher-grade transformation of FCL to DLBCL was assessed by exmining sequential biopsies; 10 polymorphisms (6 previously unreported) were observed and described., Radiation-induced Fas sensitization in prostate cancer cells is mediated through p53-dependent transactivation of the Fas gene, which can be blocked by androgen stimulation mainly through induction of c-jun, Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of putative YXX Phi and dileucine (LL) transport motifs within Ad2 10.4-14.5 for down-regulation of Fas, TRAIL-R1, TRAIL-R2, and EGFR., Fas polymorphism is associated with altered apoptotic capacity in lymphocyte cultures, and risk of lung cancer, Data show that Fas ligand is expressed on cytotoxic effector and memory cells, suggesting that the Fas/FasL system is involved in the inflammatory process observed in silicosis patients., The Fas signal mediates transcription of IL-10 in Jurkat cells upon contact with glioma cells via a protein kinase A-independent pathway., Decreased expression of Fas is seen in aggressive tumors and tumors that are poorly differentiated. Deserves further investigation, which may then shed more light on immune escape mechanisms of this tumor and thus enable novel therapeutic strategies., Fas, DR4, and DR5 are activated in drug-sensitive cells in response to anticancer drugs depending on the cytotoxic effect of each drug, lysosomal degradation by adenovirus E3 RIDalpha protein dependent on specific domains, CD95/Fas binds to the expanded binding surface of the FADD death domain, there is no significant contribution of common genetic Fas variants to the genetic risk of developing Hashimoto's thyroiditis or Graves' disease., Fas-mediated apoptosis is regulated by calmodulin, Lower gene expression of CD95 correlates with detectable blood-brain barrier leakage and active inflammation in the brain as reflected by gadolinium-enhancing lesions on MRI., Fas activation plays a role in NFkappaB inhibition-induced apoptosis in human tumor cells, Fas and Fas ligand expression are regulated in leukocytes during systemic inflammation, In this study, we show that c-FLIP(L) but not c-FLIP(S) physically binds to Daxx through interaction between C-terminal domain of c-FLIP(L) and Fas-binding domain of Daxx, an alternative Fas signaling adaptor., changes in peripheral lymphocyte subsets, and Fas expression in these subsets, during the menstrual cycle, death-inducing capacity of CD95 in Jurkat T cells, Apoptosis is related to upregulation of apo-1 receptor., FAS expression was induced by interferon-alpha in basal carcinoma cells., expression of CD95 in 15/17 human melanoma cell lines analysed, but complete lack of CD95 ligand (CD95L), the importance of the ezrin-to-CD95 linkage in CD95-mediated apoptosis, Fas is activated in vivo in human epidermis after UVB exposure, No role in the CD95L/CD95 pathway for arsennic trioxide-induced apoptosis., Fas/CD95 pathway is activated by Ad-p53 in human gliomas, O(6)MeG-triggered apoptosis in proliferating lymphocytes was preceded by a wave of double stranded breaks, which coincided with p53 and Fas receptor upregulation, This review considers the role of the Fas-FasL system as a double-edged sword in the central nervous system, no evidence for an association between the Fas promoter polymorphism at position -670 and Alzheimer's disease, TCR restimulation of activated CD4(+) T cells resulted in Fas translocation into lipid raft microdomains before binding FasL, rendering these cells sensitive to apoptosis, Fas signaling may have a role in the regulation of endothelial function and blood pressure through modulating endothelial nitric oxide synthase expression in the Akt signal-dependent manner., Fas and FasL have roles in progression of breast cancer, not a molecular prognostic factor in NSCLC, FAS-G670A gene polymorphism is associated with the severity of villous atrophy in coeliac disease, apoptotic effect of Herpesvirus saimiri Tip protein in T cells is mediated by Fas and requires the presence of active Lck in the cell, Fas was expressed in sperm of infertile men., epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes, To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes., tumour-induced mesothelial apoptosis may, in part, be mediated via a Fas-dependent mechanism., elevated values of PBMCs apoptosis and Fas both before and 6-7 months after malignant melanonma excision, the selective down-regulation of c-FLIP by small interfering RNA oligoribonucleotides was sufficient to sensitize Hodgkin/Reed-Sternberg cells to CD95 and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis, Significantly higher soluble form of fas is associated with bile duct carcinoma, results suggest that Fas antigen stimulation not only activates caspase-8, but also a distinct signaling pathway involving protein kinase(s) to induce exposure of the N terminus of Bak protein, REVIEW, thymidylate synthase and p53 have roles in regulating Fas-mediated apoptosis in response to antimetabolites, The frequent expression and coexpression of Fas, FasL, and c-FLIP in urothelial carcinomas implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumors., Assessment of Bcl-2 and Fas expression at diagnosis in acute leukemia (1) could predict responsiveness to induction chemotherapy in ALL but not in AML, CD95 death-inducing signaling complex formation and internalization in type I and type II cells occur in lipid rafts, which are a major site of caspase-8 activation, regulation of transcription by cyclin B1/Cdk1, ceramide generation and clustering of CD95 in lipid rafts early in neutrophil apoptosis, A20 also protects from Fas/CD95 and significantly blunts natural killer cell-mediated endothelial cell apoptosis by inhibiting caspase 8 activation, Cardiomyocyte necrosis and/or apoptosis via activated tumor necrosis factor (TNF) and the Fas/Fas ligand (FasL) system may be related to the development of ongoing myocardial damage., Fas/CD95-induced cell death in Jurkat cells is augmented by exposure to CO via inhibition in the activation of ERK MAPK, autoimmune biliary disease may be mediated by the Fas/FasL apoptotic system, Study results do not support hypothesis that AA genotype in FAS gene promoter is engaged in the development of cervical neoplasia., the inhibitory protein c-FLIP(L) is involved in resistance to CD95-mediated apoptosis in ovarian carcinoma cells with wild-type p53, SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells, deoxycholate induces apoptosis in colon cancer cell lines via a CD95 receptor-independent mechanism., tumor cell lines expressed cell surface IFN-gamma receptors, and when cultured for 2 days in the presence of IFNG, all exhibited a significant increase in expression of Fas receptors and exhibited intracellular fragmented DNA as a marker of apoptosis, data demonstrating that in certain highly CD95 apoptosis sensitive cells NF-kappaB is robustly activated, CD95, DR4 and DR5 localization in rafts have roles in the toxicity of resveratrol and death receptor ligands in colon carcinoma cells, A lymphoproliferative disorder could be associated with a CD95 mutation., A significant increase in p21, p53, and fas mRNA expression were reported in the proximal incompetent veins. Fas overexpression did not correlate with p53 expression level and did not correlate with apoptotic cell number in the vein layers., high level expression in Hepacivirus infected hepatocytes and inversely correlated to number of apoptotis cells., Although ischemic liver injury was not serious, due to the short ischemia time, TNFR1 and TRAIL are associated with liver ischemic injury in live-donor liver transplantation but Fas is not., CD95 requires different signalling thresholds for induction of apoptosis and activation of NF-kappaB, activation of p38 MAPK and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and TNFR1/TNFa expression, Repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3 in prostate cancer cells., association among Gal-1, Fas/Fas ligand-mediated cell death, and the mitochondrial pathway, Cells expressing Fas mutations from patients with the autoimmune lymphoproliferative syndrome reveals that formation of signaling protein oligomeric transduction structures can be disrupted by distinct mechanisms, analysis of Fas-mediated apoptosis in human thyroid epithelial cells, Fas-mediated apoptosis play an important role in pathogenesis of chronic hepatitis B., Ability of Hsp72 to inhibit Fas-mediated apoptosis is limited to type II cells where involvement of the intrinsic pathway is required for efficient effector caspase activation., Fas-670 polymorphism is not associated with inflammatory bowel disease in Chinese patients., H2O2 induces apoptosis of L02 cells by increasing cytosolic (Ca2+)i, and inducing Fas mRNA and protein expression., Fas is expressed in ovarian neoplasms, and FasL is upregulated in malignant ovarian neoplasms, TNF receptor-associated factor 2 (TRAF2) overexpression does not only block apoptosis induction by CD95 antigen but also converts this death receptor into a mediator of invasiveness in pancreatic adenocarcinoma, decreased cell-surface expression of Fas and resistance to Fas-mediated apoptosis may occur independently of loss of wt p53 expression in esophageal adenocarcinoma, loss of Fas plays an important role in the tumor formation and in the evasion of tumor cells from immune surveillance, Carriage of the TNFRSF6-670 polymorphism in the neonate was not associated with pre-eclampsia or intrauterine growth restriction., The fas Receptor Expression was evaluated by flow cytometry., Cytochrome c acts as a catalyst of phosphatidylserine oxidation during Fas-triggered A549 cell apoptosis, The A(-670)G polymorphisms in the promoter region of Fas and high levels of sFas are associated with the presence of anti-ganglioside antibodies in Guillain-Barre syndrome., increased CD95 expression on CD3+ cells and the increased levels of sCD95 in plasma may modify the immunological situation of the recipients after liver transplantation, The extracellular domains of Fas are sufficient to drive membrane FasL-induced formation of supramolecular Fas-FasL complexes, whereas soluble FasL-induced Fas aggregation is dependent on lipid rafts and the intracellular domain of Fas., Not an effective markers of silent myocardial ischemia in type 2 diabetes., Fas is effective in preventing human CD8(+) cytotoxic T lymphocyte-mediated cell killing, which may prevent xenograft rejection., Fas, Fas ligand (FasL) on activated T lymphocytes induces activation-induced cell death, The data suggest that lower expression of surface Fas, but higher levels of apoptosis-inhibiting sFas, contribute to the resistance of fibroblasts in lung fibrosis against apoptosis., CD95 capping and the subsequent cellular polarization is a ROCK signaling-regulated process that does not correlate with the induction of apoptosis, results show that IFN-induced up-regulation of Fas sensitizes MM cells to Fas-mediated apoptosis and suggest that attenuation of Stat3 activation may be a potentially important event in this process., expression in oral and oropharyngeal squamous cell carcinomas is associated with tumor stage and grade, cMet/Fas interaction may inhibit self-association of Fas receptor such that reduced DISC formation occurs in these cells after Fas receptor ligation. cMet/Fas interaction may help explain why endothelial cells are resistant to Fas-mediated apoptosis., CD47 associates with Fas upon its activation and augments Fas-mediated apoptosis., Polymorphisms of the gene encoding Fas have been linked to a variety of autoimmune diseases. Fas gene polymorphisms might be genetic markers for AIH and PBC., FAS polymorphisms contribute to susceptibility of lung cancer., Altered expression of Fas, FasL and PGF in trophoblasts of placenta influence the pathogenesis of pre-eclampsia., Expression of P-glycoprotein does not induce resistance to caspase-8 and -3 activation or anti-Fas-induced cell apoptosis., Human cells transformed with Ad12 demonstrated reduced expression of cell surface Fas antigen., tumor necrosis factor (alpha)- and Fas-induced apoptosis is blocked by inositol hexakisphosphate in human cells, The positive rates of Fas were not significantly different among gallbladder carcinoma, adenoma, dysplasia and chronic cholecystitis., NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium, Data strongly indicate that an increment of soluble FAS/soluble FASL ratio after treatment could be an excellent marker of chemosensitivity in colorectal cancer., We also showed that, in contrast to the stimulation of Fas by an agonistic antibody, Fas aggregation did not occur after irradiation., serum sAPO-1 appears to have an important relationship to serum lipid levels and body adiposity in healthy adults, Plasma levels may be a marker for chronic hepatitis C infections., Decreased expression of Fas is associated with disease progression in urothelial cancers, The downwards expression of Fas and the upwards expression of FasL in nasal polyps may inhibit the cellular apoptosis and the enhanced hyperplasia., Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease., Altogether, these findings reveal that NO inhibits YY1 DNA-binding activity through S-nitrosation and consequently results in upregulation of Fas expression and tumor cell sensitization to Fas-induced apoptosis., Our data indicate an association between preterm premature rupture of membranes and increased prevalence of neonatal AG genotype at -670 Fas promoter gene., The combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy., Functional promoter haplotypes of FAS are associated with the phenotype of SLE characterized by thrombocytopenia., p75(NTR) and Fas receptors could share common signalling pathways., The lipolytic pathway responsible for the generation of free fatty acids (FFA) during Fas/CD95-induced apoptosis in Jurkat cells, was characterized., An association between -670A > G polymorphism in promoter of FAS protein and the grade of necrosis in periportal areas in patients with chronic hepatitis C, Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression, and can counterattack the immune system via increasing FasL expression, overexpression of c-FLIP protects ALK+ ALCL cells from FAS-induced apoptosis and may contribute to ALCL pathogenesis., Based on the FAP-1- and dynamin-dependent regulation of Fas translocation, we have created human melanoma lines with different levels of surface expression of Fas., Increased concentrations of soluble Fas in sera is associated with B-cell chronic lymphocytic leukemia, thymosin beta-4 increases colon carcinoma apoptosis resistance triggered by FasL and apoptosis inhibitors by downregulating Fas and upregulating Survivin expression, CD95-death-induces a signaling complex formation resulting in a robust sensitization for CD95-mediated apoptosis in autoimmune lipodystrophy., Coligation of Fas with CD55 or CD59 inhibits the apoptotic signal, whereas CD28 recruitment amplifies the Fas signaling pathway., c-FLIP confers Tax-mediated resistance toward CD95-mediated apoptosis., Tax inhibits Fas-mediated apoptosis by up-regulating c-FLIP expression in HTLV-I-infected cells, and NF-kappaB activity plays an essential role in the up-regulation of c-FLIP, UV light induces a redistribution of Fas-receptor in lipid rafts, This work suggests for the first time a possible harmful effect of Fas -670 AA genotype on liver graft survival, whereas the Fas and FasL polymorphisms are not associated with acute or chronic rejection in liver graft recipients., Down-regulating bcl-2 and up-regulating fas mRNA expression were also involved in the mechanism of HCMV-induced apoptosis., Novel autocrine regulatory loop whereby activated chondrocytes may amplify CD95 signals by inducing synthesis of CD95 ligand., Inhibition of Flip by antisense oligonucleotide reverted the resistance of CD LPLs to FAS-induced apoptosis., Fas downregulation and a consequential increased resistance to FasL-triggered apoptosis resulting from upregulated MMP-7 in colorectal cancer cells could be a key mechanism for their escape from the immune surveillance, A single A>G nucleotide substitution at position -670 in the maternal but not neonatal TNFRSF6 gene coding for Fas is associated with a higher risk for hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome., Germ-line polymorphism of Fas gene promoter -670 may be associated with the risk of cervical cancer in a Japanese population., The alteration of the up-regulated Fas expression might be characterized during the tumor progression stage., Study concludes that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects., IFN-gamma primes VSMCs to Fas-induced apoptosis, in part by relocation of Fas to the cell surface, a process that involves PI3K, Akt, and Jak-2/Stat1, There may exist significant correlation between the expression of Fas/FasL and the development of the infantile hemangioma cells., Cyclosporin A (CyA) and bongkrekic acid (BK) prevented Fas-induced apoptosis in two type I cell lines (H9 and SKW6.4) and two type II cell lines (Jurkat and CEM)., Bcl-2 and Fas expressions were significantly higher in thymomas compared with normal thymus., Fas ligation suppresses CD3/CD28-initiated NF-kappaB activity by decreasing the levels of the NF-kappaB p65 subunit through a caspase-dependent mechanism., Increased Fas expression results in a higher susceptibility to Fas-mediated apoptosis, which contributes to increased levels of intracellular activated caspase-3 and accelerates apoptosis of T lymphocytes in patients with systemic lupus erythematosus., Results suggest that P. aeruginosa type III secretion system not only accounts for higher expression of Fas and release of FasL but also leads to overproduction of NO and to a NO/iNOS-dependent up-regulation of Fas-FasL proteins., caspase-2 is activated at the DISC but does not play an initiating role in the CD95-induced apoptosis., Genetic evidence is provided for the two-pathway model of CD95-mediated apoptosis, pathways which differ in efficiency of death-inducing signaling complex formation and requirement of mitochondria for caspase activation., The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS, Postmenopausal women with elevated levels in Fas antigen showdifferent leukocyte and hemoglobin levels., We conclude that hypoxia triggers a p53-dependent gene expression pattern distinct from that induced by other stress agents and that Fas/CD95 is a critical regulator of p53-dependent apoptosis upon hypoxia., no age-dependent changes in the Fas/Fas ligand system could be detected in human islets, The ability of MHC class II to modulate activation of the pro-apoptotic receptor Fas by blocking the accessory molecule FADD and to delay apoptosis induction could allow for cytokine secretion by H pylori-infected gastric epithelial cells., Fas-FasL signal transduction pathway plays an important role in the induction of T cell apoptosis., sFas, sFas-L, and MMP-3, which were significantly elevated in sera of active untreated adult-onset Still's disease patients and paralleled disease activity, may be involved in the pathogenesis of this disease, Fas and FasL serum concentrations in patients coinfected with HIV and HCV indicate programmed cell death., Alkyl resorcinol exerts its cytotoxic effect in both hepatocellular cell lines through apoptotic cell death. For Hep3B, cells with mutated p53 and Fas, apoptosis would proceed by p53- or Fas-independent pathways., in human lens epithelial cells, Fas is induced by 4-hydroxynonenal in a concentration- and time-dependent manner; results show an important role of 4-HNE in regulation of the expression and functions of Fas, These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans., sFas concentrations are increased and sFasL are decreased in subjects at high cardiovascular risk, suggesting that these proteins may be novel markers of vascular injury., The mean sFas values were found higher in rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM) and osteoarthritis (OA) than in control although no differences were found in systemic sclerosis (SSc) and Sjogren's syndrome (SS) patients., The main pathway by which Fas signaling regulates the levels of Bim expression in human T-cell blasts is the death-domain- and caspase-independent generation of discrete levels of H2O2, which results in the net increase of Foxo3a levels., We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels., FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing, CD95 palmitoylation facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling, Fas cell death signaling requires palmitoylation, CD95 alters NOSI expression to contribute to diabetic gastroparesis., Our results suggest that growth factor may contribute to the resistance of cancer cells to Fas-mediated apoptosis in an autocrine or paracrine fashion., These findings indicate that functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer., lymphocyte expression of CD95 is influenced by acute exercise in healthy children and adolescents, Results suggest that EGFR-catalyzed CD95-tyrosine phosphorylation is involved in the CD95/CD95-oligomerization process, which is induced by proapoptotic stimuli and is required for apoptosis induction., Soluble Fas concentrations in the umbilical cord were significantly lower than in maternal serum., These results demonstrate that NBS1 suppresses the CD95 death receptor-dependent apoptotic pathway after gamma-irradiation and evidence is given that this is achieved by regulation of the PI3-K/AKT survival pathway., induction of the short c-FLIP isoforms inhibits the onset of CD95-induced apoptosis in primary CD40-stimulated ALL cells despite high CD95 expression., We have tested two SNPs in the FAS gene in 223 Italian patients with non-familial AD from Southern Italy. No significant differences in allelic and genotypic distributions were found between cases and controls., Mechanisms other than the Fas-Fas ligand pathway may induce T cell apoptosis in MDS, analysis of 5' region mutations of the FAS/CD95 gene in nodal diffuse large B-cell lymphoma, polymorphism of the Fas gene at position -670 does not influence susceptibility to type 1 autoimmune hepatitis, but may affect the early development of cirrhosis, results demonstrated that FAS promoter polymorphism was significantly associated with the level of soluble FAS production in normal subjects, Patients with active and inactive juvenile-onset systemic lupus erythematosis have a different profile of Fas and Bcl-2 expression., The results suggest that both N-glycosylation sites of the extracellular domain of Fas are occupied with large N-glycans that play a role in the expression of the glycoprotein., Germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas, The frequent expression and coexpression of Fas, FasL and c-FLIP in colorectal carcinoma implicates c-FLIP as an inhibitor of the Fas-FasL-induced death pathway in these tumours., FAS A-670G was not associated with the risk of developing esophageal cancer, The serum levels of soluble FAS were studied in patients with multiple organ failure with complicating peritonitis., The SPF45 regulates alternative splicing of the apoptosis regulatory gene CD95; 2.1-A crystal structure of SPF45-UHM in complex with a ULM peptide from SF3b155 is reported., Fas was significantly more frequently overexpressed in thyroid cancer, indicating its role in thyroid tumorigenesis., Fas/FasL gene polymorphysms are possible that different mechanisms function in apoptosis balance in papillary thyroid cancer development, Fas receptor and Apaf-1 were down-regulated in stage III colorectal cancer cell line., Bcl-X(L) conferred complete resistance to apoptosis induced by fas ligation in atherosclerotic carotid artery., The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms and risk of differentiated thyroid carcinoma and salivary gland carcinoma., FAS polymorphism is associated with prostate cancer development, Fas-bearing cancer cells undergo apoptosis by FasL produced by disc cells, which may be considered as a potential biochemical explanation for the disc's resistance to metastatic cancer., and CAPE sensitize astrocytoma cells to Fas-induced apoptosis in a redox-dependent manner, Serum level of FAS was determined during chemotherapy of lung neoplasms., Fas antagonism by Met is abrogated in human fatty liver disease., There was no relationship between Fas-1377 G-->A polymorphism and lung cancer, the cytotoxic granules-dependent cell death in ALPS may compensate for Fas deficiency in T lymphocytes. Furthermore, a novel AICD pathway is identified as a unique alternative to Fas apoptosis in human peripheral T lymphocytes., The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk., A higher expression of apoptotic molecules (Fas and FasL) on lymphocytes occurs before the onset of acute ischaemia and contributes to the plaque rupture and acute coronary syndrome., stimulation of the beta integrin signal of T cells by contact with tumor cells may trigger a novel protective signaling through the Phosphatidylinositol 3-kinase/Akt pathway of T cells against Fas-mediated apoptosis, Disruption of actin by cytochalasin D (cytD) or lantrunculin A remarkably reduced CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells while their spontaneous apoptosis was unaffected., Recombinant fourth FAS1 domain of BigH3 has been crystallized and characterized., This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets., Allografted cells undergo Fas-mediated apoptosis induced by CD8+ T cells. Our objective was to prevent human keratinocytes from immunologically induced apoptosis by blocking the Fas ligand/Fas interaction., data demonstrated that the progression of TGCT is associated with the increased expression of FasL and a concomitant reduction of Fas, reconstitution of ATM kinase activity decreases FLIP protein levels and restores Fas sensitivity in Hodgkin lymphoma-derived cells, no significant associations found between Fas or FasL promoter polymorphism with hepatitis B virus clearance & HBeAg clearance; -1377G>A in Fas promoter region showed protective effect to hepatocellular carcinoma occurrence, Paeoniflorin inhibits A549 cell proliferation via Fas/FasL apoptosic pathway., risk of breast cancer may be elevated among women with polymorphisms in the FAS gene and detectable PAH-DNA adducts., The a functional Fas promoter polymorphism is significantly associated to susceptibility, clinical manifestation, and survival in ATL., The increase in Fas and CTLA4 molecules in multiple sclerosis patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-beta., Resistance to Ara-c up-regulates FAS activity., CK2 regulates endometrial carcinoma cell sensitivity to TRAIL and Fas by regulating FLIP levels., display reduced capacity for Fas-mediated death-inducing signaling complex formation, FAS-1377G > A, FAS-670A > G and FASL-844T > C gene polymorphisms may not be associated with the susceptibility of coal worker's pneumoconiosis in Han nationality., TNF-alpha sensitizes primarily resistant endometrial stromal cells to Fas-mediated apoptosis., CD95L-induced endosomal acidification, ceramide formation, and downstream events, such as p47(phox) phosphorylation, ROS formation, CD95 activation, and apoptosis., Semaphorin3A (Sema3A) triggers a proapoptotic program that sensitizes leukemic T cells to Fas (CD95)-mediated apoptosis., lower level of soluble Fas may provide proper microenvironment for increased apoptosis of trabecular meshwork cells in primary open angle glaucoma, FAS -1377 G-->A polymorphism may be associated with an increased risk of lymph node metastasis in Korean cervical cancer patients., Soluble Fas and soluble Fas ligand are increased in the joints of patients with rheumatoid arthritis and osteoarthritis., Therefore, CHX treatment is granting the CD95-mediated pathway the ability to bypass the mitochondria requirement to apoptosis, much alike to what is observed in Type I cells., Cytochrome C up-regulates expressions of fas to induce apoptosis of HL-60 cells., Association between the Fas exon 3 A>G polymorphism and osteosarcoma risk., In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes., fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in multiple sclerosis through Fas/FasL-mediated mechanisms, in HCV and HIV infections, the concentration of sFas, but not sFasL, in serum correlates with the concentration of ssDNA in liver tissue, The role of alpha(v)beta(3) and Fas as the mediators of streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is described., This study identifies mitogen-activated protein kinase/ERK/Mcl-1 as an important survival signaling pathway in the resistance of melanoma cells to Fas-mediated apoptosis., Study indicated that c-FLIP(L) might be a suppressor of Fas-mediated apoptosis in Fas antigen expressing colon carcinoma cells., Fas is upregulated in cells deficient for SBDS protein. Inhibition of SBDS results in accelerated apoptosis through the Fas pathway., In transgenic mice with mutations in the Fas/FasL pathways, impaired function of memory CD8+ T cells increases their susceptibility to recurrent/latent infections., FAS-1377, FAS-670 and FASL-844 polymorphisms are not susceptible factors of silicosis. The FAS-1377G/-670G haplotype might be a susceptibility marker of silicosis., data suggest that there is a different regulation and function of the Fas/FasL system in early human pregnancies. Aberration of the Fas-mediated apoptosis may represent one of the execution-step necessary for pregnancy loss in missed miscarriage cases., Our findings suggest that the changes in the expression of apoptotic proteins (Fas/FasL and caspase 8) in the thyroid gland of patients with autoimmune Graves Disease and Hashimoto's thyroiditis reflect their involvemetn in the pathogenesis., Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases., Fas activation induces apoptosis of endometrial epithelial cells (EEC) via p38 MAPK and JNK, thereby promoting trophoblast outgrowth on EEC., FAS and FASL genotypes of the hosts are important determinants in the pathogenesis of gastric atrophy and intestinal metaplasia in H. pylori-infected individuals., These results indicate that T. gondii inhibits Fas/CD95-mediated apoptosis in type II cells primarily by decreasing the apoptogenic function of mitochondria., placental FasL expression was significantly lower in abnormal pregnancies than in normal ones. However, no such difference was observed for Fas expression., These results show that the Fas/FasL-system mediated by caspase-3 activation plays a role in Clonorchis sinensis-infected hepatocyte apoptosis., Soluble Fas could play a role in germ cell apoptosis in varicocele-associated infertility., high IL-7 levels associated with lymphopenic conditions may simultaneously induce sensitivity to Fas-mediated apoptosis in nonactivated T cells and increase Fas-induced costimulatory signals in T cells recognizing low-affinity antigens., the FAS-670A allele significantly influences the susceptibility to SSc., a functional link between HuR as repressor of alternative Fas splicing and the molecular mechanisms modulating programmed cell death., Gastrin and somatostatin play important roles in the regulation and control of cell apoptosis in large intestinal carcinoma, and the mechanism may be directly related to the aberrant expression of Fas and Fas ligand., Our results suggest a systemic nature of uveitis with persistent activation of the immune system. Apoptosis may play regulatory role in ocular inflammation of patients with uveitis., In Graves' disease patients, the intensity of Fas expression on CD4 and CD8 lymphocytes was reduced and sFas levels in serum were simultaneously increased when compared with Hashimoto's thyroiditis patients and controls., there is a functional link among apoptosis induction, U2AF65 cleavage, and the regulation of Fas alternative splicing, a specific domain in Fas, topologically and functionally distinct from the death domain, which regulates neuritogenesis via recruitment of ezrin and activation of Rac1, a homogeneous subset of CD27-,IgD-,CD95+ memory B cells with an activated phenotype was identified in lupus patients., genetic variants in the FAS gene may affect the risk of vitiligo in Chinese populations, very high expression of CD40 on BCP-ALL blasts is an independent prognostic marker indicative of superior relapse-free survival that may in part be due to CD40-dependent death receptor up-regulation, Up-regulation of Fas expression in CD8+ T cells is related to increased apoptosis of circulating CD8+ T cells in patients with gastric cancer., suggest that antineuronal antibodies may contribute to neuronal dysfunction observed in patients with neurogenic chronic intestinal pseudo-obstruction via autoantibody-mediated activation of autophagy involving the Fas receptor complex., Promoter genetic variants may be related to sarcoidosis disease risk in African-Americans., In chronic kidney disease patients, the decrease in renal function is followed by a decrease in sFas (serum FAS Protein) clearance and an increase in serum sFas; sFAS is increased in patients, lack of Fas in primary breast cancer is associated with perilymphatic fat infiltration, CD95 stimulation results in the formation of a novel death effector domain protein-containing complex, To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis, This review summarizes the functional relevance of FasL-Fas signaling-a quintessential death ligand/receptor system-in different neurological disease models ranging from traumatic, inflammatory and ischemic to neurodegenerative processes [review]., Soluble Fas antigen is greatly increased in chronic hepatitis C and hepatocellular carcinoma compared to normal controls., these findings from two independent CF patient cohorts indicate that allelic variants within FAS intron 2 alter FAS gene expression and that these functional variants modulate the manifestation of CF disease., In leukemia patients, negative correlation was observed between selenium and VEGF and Fas expression., SOD coenzyme can effectively regulate Fas/FasL signal transduction and block apoptosis of alveolar macrophages from pneumoconiosis patients., there is an association of a Fas Antigen (Fas)-670 (A/G) gene polymorphism with the risk of cervical cancer in a North Indian population., Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation, These results reveal a cytochrome c-independent branch of FAS-induced apoptosis involving cleavage and cytoplasmic release of mitochondrial Cyt b, Laryngocarcinoma cells could induce apoptosis of T lymphocytes through the Fas-FasL system., Bbrief cross-linking (15 min) of Fas/APO-1 on Jurkat T cells or primary human T cells renders these cells appetizing to human monocyte-derived macrophages., Immunohistochemistry using antibodies to determine the protein expression of Fas, Fas-L, Bax, Bcl-2, p53 and c-Myc in skin of venous ulcer patients., The expression rate of membrane Fas on CD4+ T cells was significantly increased in idiopathic thrombocytopenic purpura patients., HGF and EGF can interfere with CD95-mediated apoptosis and the action of cytotoxic T-cells through multiple mechanisms in human hepatocytes, In contrast with classical mechanisms of splicing regulation, RBM5 does not affect early events of splice site recognition that lead to Fas exon 6 definition., Cutaneous T-cell lymphoma cells exhibit a mechanistic connection between transcriptional regulation of FAS and sensitivity to FAS-mediated apoptosis., Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation., leptin at a physiological serum concentration, may regulate the remodeling of the human endometrial epithelium by stimulating cell proliferation and enhancing the Fas-specific intracellular apoptotic signaling pathway., analysis of the expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx, Cytomegalovirus (CMV) infection development and mRNA fas transcription levels (CD95) in resting (GO) and proliferating (S-phase) human lung embryo fibroblasts (HLEF-110044 line) were studied, SBDS loss results in abnormal accumulation of Fas at the plasma membrane, where it sensitizes the cells to stimulation by Fas ligand, high level of sFas in rheumatoid arthritis patient blood, correlation with disease progression; elevated levels in systemic lupus erythematosus patients, correlation with leucopenia, and tissue and organ damage, High serum FAS is associated with breast ductal carcinoma., In chronic HCV infection, steatosis up-regulates hepatocyte CD95/Fas and thus increases apoptosis, which facilitates inflammation and fibrosis., Results showed that membrane Fas (mFas) expression levels were significantly higher (P < 0.01) among SLE patients than those in healthy controls., Data show that Fas activation opens clathrin-independent portals in mature T cells, which drive rapid internalization of surface proteins such as CD59 and depend upon actin-regulating Rho GTPases., results indicate that the apoptosis markers Fas receptor and caspase-3 might play a significant role in glaucoma neuropathy at the stage of absolute glaucoma, our data do not support a role for the Fas counterattack in colorectal carcinogenesis in Lynch syndrome., Serum markers of the TNFalpha and Fas-pathways are strongly associated with decreased renal function in nonproteinuric type 1 diabetic patients., Fas resistance can be caused by reduced Fas expression, which is a result of an unidentified mode of regulation, Enhanced expression of TNF-R1 and Fas receptors (CD95, APO-1)on the apoptotic hepatocytes suggest that both may be involved in the pathogenesis of FHF and seem to be potential therapeutic target., PTEN influences Fas signaling, at least in part, by regulating PEA-15 phosphorylation and activity that, in turn, regulate the ability of Bcl-2 to suppress Fas-induced apoptosis., role of Retinoic acid in abrogating mitogen-mediated repression of Fas DISC assembly, thus enhancing Fas-induced apoptosis in leukemic T cells, human Fas-FADD death domain complex 2.7 A crystal structure, The results indicate that mitochondrial-death proteins like caspases may influence the upregulation of the death receptor Fas, and the inhibition of caspases prevents gp120-induced apoptosis., difference in gene expression between acute rejection and non-rejection in kidney graft biopsies, FAS and FASLG SNP may be associated with idiopathic azoospermia or severe oligozoospermia., Regulatory T cells (Treg) from head and neck cancer patients express CD95 ligand (CD95L), up-regulate CD95 and CD95L expression, and suppress CD8-positive responder cell proliferation by inducing Fas-mediated apoptosis., Loss of Fas expression might play a role in tumorigenesis in some prostate cancers possibly by inhibiting apoptosis mediated by Fas., The expression of Fas, CTLA-4 and RhoBTB2 at the mRNA level is involved in genesis and progression of breast cancer., T cell surface expression is higher in patients with active systemic lupus erythematosus than in healthy controls, significantly elevated cancer risk was associated with AA variant genotype when all the eligible studies were pooled into the meta-analysis, Polymorphisms in the FAS is associated with early stage non-small cell lung cancer., The expression of Fas protein is significantly higher in the viral myocarditis and dilated cardiomyopathy groups than in that of the control group., In human ejaculated sperm, immunofluorescence analysis showed Fas localized in the middle piece of sperm flagellum where mitochondria are grouped., Fas undergoes a change in its functionality in oxaliplatin-resistant cells inducing survival pathways instead of apoptotic signals., The combination of FK228 and FU can up-regulate the Fas mRNA level in hepatoma cell lines., Study show that there is an increase in sFas level in schistosomal associated bladder cancer compared to other the groups., Results show no significant correlation between corneal graft rejection, rejection recovery and the Fas -670A/G gene polymorphism., The FAS -670A/G polymorphism may be associated with overall survival time of patients with colorectal cancer, Fas can be a novel target for the treatment of pituitary adenomas, The data presented here stress the importance of the Fas/FasL system for signal initiation via the TCR-CD3 complex and provide further arguments for a retrograde signaling capacity of FasL or a crucial role of Fas as a co-stimulatory molecule., The elevated levels of sCD95 antigen and CD95+ mononuclear cells were revealed in IS and EAC in moderate COPD., this study demonstrates high CD154 and FAS expression as a characteristic feature of SLE., The distribution and regional location of Fas and FasL in gastric epithelial cells, gastric carcinoma cells, normal gastric stroma-infiltrating lymphoid cells and tumour-infiltrating lymphoid cells in human gastric carcinoma, was studied., Data suggest that CD95/CD95L-mediated silencing of T cell activation represents a novel mechanism of immune evasion., the association of the glycosphingolipid GD3 with microtubular cytoskeleton at very early time points following Fas ligation was shown., p18 subunit of caspase-8 was necessary for Bid cleavage and the mitochondria pathway might be dependent on the release of p18 subunit from active caspase-8., Genetic polymorphisms of Fas and FasL in apoptotic pathway are associated with the risk of development of cervical carcinoma., Among breast cancer patients without lymph node metastasis, patients with Fas-1377 AA genotype may have a worse survival rate., Results highlight the role of recruitment of Fas/CD95 signaling in lipid rafts in antimyeloma and antileukemia chemotherapy., FAS and FASLG polymorphisms may not contribute to risk of gastric cancer in the southern Chinese population., It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children., Cooperation between the p53-REs in the promoter and the intronic p53-binding site resulted in maximal transcriptional activation of the CD95 gene by the p53 family., Fas expression is upregulated in apoptotic HeLa cells treated with co-immobilized cytokines., Fas-670 polymorphism was associated with the development of Crohn's disease and ulcerative colitis in the Tunisian population., findings obtained with the inhibitors of actin polymerization underscored that CD95 is able to induce at least two types of apoptotic signal., Results suggest that virion-associated Vpr can contribute to the depletion of CD4(+) lymphocytes either directly or by enhancing Fas-mediated apoptosis during acute HIV-1 infection and in AIDS., Suppression of p38 MAPK sensitized T cells to Fas-mediated apoptosis and increased caspase-8 and caspase-3 cleavage, This study demonstrates an association between the maternal Fas (-670) single-nucleotide polymorphism and the development of intrauterine growth restriction., Results show that no striking relationship was found in expression patterns of p53, Bcl-2, caspase-3, and Fas., Selective inhibition of AKT renders normally resistant first-trimester trophoblast cells sensitive to FAS-mediated apoptosis by regulating XIAP expression., Interference with Puma induction or expression of MCL1 or BCL2 significantly reduced both glucocorticoid- and FAS-induced cell death in p16INK4A-reconstituted leukemia cells., alternatively spliced variant CD95 transcripts expression was 'reversible' by CD40 activation in CD95-apoptosis-resistant, human, B-cell lymphoma, Findings strongly suggest that Fas-mediated activation of executioner caspases and induction of apoptosis do not depend on apoptosome-mediated caspase-9 activation in prototypical type II cells., dysregulation of Fas expression is a common feature of Sezary syndrome, The FAS gene, which plays a role in apoptosis, may be associated with AD by modulating the apoptosis and neuronal loss secondary to AD neuropathology., Non-apoptotic Fas signaling activated in the autocrine manner or through microenvironment derived factors can regulate invasiveness of glioma cells via modulation of MMP-2 activation, likely by controlling TIMP-2 expression., Data suggest that c-FLIP downregulation represents a mechanism by which diverse anticancer regimens can facilitate tumor cell execution by CD95/Fas through the direct pathway of caspase activation., Downregulation of Fas expression in keratinocytes and lymphocytes of oral lichen planus specimens, together with upregulation of FasL, may serve as initial prognostic biomarker in oral cancer development., Increased sFas in multinodular goiter may indicate increased expression of alternatively spliced Fas mRNA variant and decreased expression of cell-surface Fas protein, Evaluation of CD95 levels may be used routinely in clinical practice to assess the level of immunosuppression during treatment of human cytomegalovirus infection after orthotopic liver transplantation., the importance of Fas/FasL-mediated apoptosis in lymph node homeostasis, The FAS-670 G allele could be used as a genetic risk marker for the metastasis of NPC patients., Decreased Fas expression in osteosarcoma cells is not secondary to DNA methylation of CpG islands in the Fas gene. Fas expression cannot be increased by using demethylation agents., The Fas 670 G variant may have an influencing role in preeclampsia., Suppression of ERK signaling evokes autocrine Fas-mediated death in arachidonic acid-treated human chronic myeloid leukemia K562 cells., Phospholipase A(2) (PLA(2)) from Naja naja atra venom increased Fas and FasL protein expression in human leukemia K562 cells, Study shows an essential role for apoptosis signal-regulating kinase 1 (ASK1), together with both c-jun-N-terminal kinase (JNK) and p38 pathways, and caspase-8 in Fas-induced apoptosis., The FAS -670A>G polymorphism plays a role in limited cutaneous systemic sclerosis susceptibility., Data show a novel mechanism for the sensitization to DR-induced apoptosis linking glucose metabolism to Mcl-1 downexpression, and provide a rationale for the combined use of DR ligands with AMPK activators or mTOR inhibitors in the treatment of cancers., CLIPR-59 may act as a typical chaperone, allowing a prompt interaction between tubulin and the raft component GD3 during cell apoptosis triggered by CD95/Fas, promoter polymorphisms might contribute to individual susceptibility to systemic lupus erythematosus in iranian patients, Levels of sFas were elevated in chronic kidney disease and ESRD patients compared to controls., Data show that down-regulation of CD95 mRNA in peripheral blood T cells may play an important role in inhibiting oncogenesis and development of primary NSCLC in the elderly., direct evidence of increasing densities of the Apo/Fas complex on neutrophils in cardiac surgical patients, Our results revealed a novel biochemical pathway that regulates the expression of CD95 ligand and potentially other downstream targets of NFAT activation., In rheumatoid arthritis fibroblast like synovial cells phosphorylation of Akt protects against Fas-induced apoptosis through inhibition of Bid cleavage., Fas expression was elevated in Epstein-Barr virus-associated gastric carcinoma., Data suggest that the FAS 1377G>A and IL10 592C>A polymorphisms could modify disease-free and overall survival in women with lymph node-positive breast cancer., These data suggest a protective role for TNFR2/Fas in the pathogenesis of traumatic brain injury., Abnormal Fas and FasL expressions in gastric carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer., In diffuse large B-cell lymphomas, positive CD95 and negative BCL2 expression are independent prognostic factors for overall survival., Psoralen and ultraviolet A upregulated Fas expression and downregulated FasL expression in NB4 leukemic cells, which induced apoptosis., FAS polymorphisms not significantly related to OSCC development/malignant potential of OL. substance use on OSCC development differentiated by FAS polymorphisms. FAS A(-1377)-G(-670) haplotype may impact malignant potential of OSF., Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome., Data show that the TNF/Fas/TRAIL pathway is modulated by nucleophosmin-anaplastic lymphoma kinase in anaplastic large cell lymphoma., A reduced risk of alopecia areata appeas to be associated with the FAS 670AG genotype [(OR) 0.43; 95% confidence interval (CI) 0.22-0.86] when compared with FAS 670AA but no risk is associated with any of the FAS 1377G>A and FASLG 844T>C genotypes., Results describe serum concentrations of soluble Fas in patients with malignant and benign tumors of different location and morphology., Results describe the relationship of serum sFas, leptin, and VEGF levels in patients with serous ovarian cancer and the main clinical morphological characteristics of the disease and the relapse-free survival prognosis., REVIEW, FAS polymorphisms are not associated with acute myeloid leukemia risk in Koreans., Inhibition of Fas-mediated apoptosis may not be due to gene mutations in the critical exon 9 of the Fas gene and exon 1 of the FADD gene in esophageal squamous cell carcinoma., Over-expression of Fas reverses drug resistance of H446/CDDP cells, possibly due to the increased cell sensitivity to apoptosis and the decreased expressions of GST-pi and ERCC1, Results suggest a modestly increased risk for SPM after index SCCHN with FAS -670 A > G and FASLG -844 C > T polymorphisms and an even greater risk for SPM with multiple combined FAS and FASLG risk genotypes., results demonstrate that CD95 has a growth-promoting role during tumorigenesis and indicate that efforts to inhibit its activity rather than to enhance it should be considered during cancer therapy, Production of sFas may play a critical role in the carcinogenesis of intestinal-type gastric cancer. sFas serum level may serve as a non-invasive tool for early diagnosis of gastric cancer., High serum Fas is associated with cancer., Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes., FAS status and macrophage number and between FASL status and lymphocyte number in skin metastasis but not in primary lesions might point to diverse FAS/FASL interaction between neoplastic cells and macrophages in the different microenvironments, miR-200c sensitizes cells to apoptosis mediated by CD95., The level of Fas protein was up-regulated in A375 cells after exposure to all-trans retinoic acid., Fas is able to trigger intracellular signalling events driving both apoptosis and activation of T cells but that cell fate is determined by quantitative and qualitative differences in intracellular signalling following Fas stimulation, Fas, TRAILR1 and TRAILR2 genes may not be mutated in prostate carcinomas., Results suggest that Jurkat cells might decrease the survival rates of A549 cells and enhanced its apoptosis and immune evasion partly via Fas/FasL pathway., CD95 is not functional in red blood cells and activation of this death receptor does not lead to the exposure of phosphatidylserine., Polypeptide from Chlamys farreri could attenuate UVA-induced Fas and c-fos expression, which may attribute to its protective effect against UVA-induced damage in HaCaT cells., The study of expression of apoptosis receptors (CD95+) on the surface of neutrophils from cervical secretion of women with chlamydial infection and the possibility of its correction by magnetic laser radiation, common SNPs associated with suscptibility to acute lung injury, Data indicate that Fas G670A and G1377A (G-A) was observed to be associated with a significant increase in prostate cancer (CaP) risk., Polymorphisms of FAS is associated with nasopharyngeal carcinoma., TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55., Esophageal squamous cells are sensitized to CD95-mediated apoptosis following bile salt exposure and could exert a selection pressure that contributes to the pathophysiology of Barrett's esophagus., findings show that the Fas-FADD death domain (DD) complex forms an asymmetric oligomeric structure composed of 5-7 Fas DD and 5 FADD DD, whose interfaces harbor associated autoimmune lymphoproliferative syndrome mutations, In late rheumatoid arthritis, the rate of apoptosis and p-53-immunostaining intensity increased, Bcl-2-immunostaining intensity decreased, as did the sFas level., Results suggest that the CD95-DD+CT, These results suggest that the TIA and HuR cellular ratio influences cell-type specific Fas exon 6 splicing pattern., A Fas gene SNP was associated with reduced risk of infections with HSV-2 in South african women., many CTCL patients harbor the homozygous FAS promoter -671 GG single nucleotide polymorphism capable of blunting its response to interferon, ymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin., extrinsic Fas/FasL-dependent apoptosis pathways in cardiac myxomas were proved by both RNA and protein levels, Both Fas (cytoplasm and membrane) and FasL were significantly upregulated in syncytiotrophoblast of molar pregnancy., Data demonstrates the importance of CD40 augmentation of Fas dependent death in primary and malignant cholangiocytes cells., data suggest that PP1201 functions as an anti-apoptotic protein and its increased expression in vascular cells can contribute to homeostasis by reducing Fas trafficking to the cell membrane, The elevations of IL-18 and sFas(Apo/1-CD95) serum concentrations in SLE patients are significantly correlated., BCL-2 gene expression showed a significant correlation with FAS, while such a correlation was not observed between BCL-2 and TP53 in breast cancer patients, Patients with nonalcoholic steatohepatitis (NASH) had significantly higher levels of CK-18 and soluble Fas than patients in the "not NASH" group., Data show that significantly elevated plasma levels of resistin (p<0.0001) and sFas (p=0.0038) as compared to controls., Fas promoter methylation correlates inversely with the level of Fas transcript, protein, and apoptotic sensitivity in cutaneous T-cell lymphoma., Data show that high CD95 expression is a negative independent prognostic factor in RCCs which could be used to identify high-risk patients with a poor clinical prognosis., Mutation in the 3' splice site associated with the alternatively spliced exon 6 of the Fas receptor CD95 leads to constitutive exon 6 skipping resulting in autoimmune lymphoproliferative syndrome., Serum sFas is significantly elevated in preeclampsia and is correlated with some important clinical, laboratory, and Doppler parameters., Fas induces KC release by a mechanism requiring MyD88, mitogen-activated protein kinases, and likely activator protein-1, Low expression of Fas and high expression of FasL are more often in colon tumor stage D and in liver metastasis, polymorphisms of FAS LG, FAS promoter and TP53 may have a role in increased risk of coronary artery disease progression, we discuss the role of Ca(2+) ions as modulators of CD95 signaling--REVIEW, Data show that IL-32alpha stimulates Fas and ULBP2 expression via activation of p38 MAPK, which increases NK susceptibility of chronic myeloid leukemia cells., Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis., Post-translational modifications (S-nitrosylation of cysteine residues 199 and 304) in the cytoplasmic domain of Fas promotes fas ligand-mediated apoptosis in cancer cells., elevated serum levels before stent implantation are protective against restenosis, Stable over-expression of extrinsic Fas gene can significantly ameliorate the sensitivity to Fas-mediated apoptosis in human malignant T-cell., knockdown of FAS and several components of the NF-kappaB pathway specifically enhanced cell death induced by the EGFR TKI erlotinib in EGFR-mutant lung cancer cells, Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex, Celastrol can induce apoptosis of human non-small-cell lung cancer A549 cells through activation of both mitochondria- and Fas/FasL-mediated pathways., Intracellular apoptotic signals in HHUA cells are constitutively activated and regulated by STAT3-mediated signals., Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors, findings define haploinsufficiency as a common disease mechanism in autoimmune lymphoproliferative syndrome patients with extracellular FAS mutations, The aim of this study was to evaluate serum concentrations of sFas, sFasL, and their potential regulators (MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2), in children and young adults chronically dialyzed., the presence of IL-1 and/or IL-6 during activation of human CD8 T cells attenuates Fas-mediated AICD, whereas IL-12 increases the susceptibility of activated CD8 T cells to this form of cell death, E2-CD81 engagement may contribute to Hepatitis C virus-associated B cell lymphoproliferative disorders and insufficient neutralizing antibody production., The lack of significant differences in the expressions of Fas in correlation to other clinicohistological parameters indicates the existence of mechanisms that have a greater impact on the process of differentiation of gastric cancers., Higher soluble Fas levels were associated with hepatosplenomegaly in children with acute lymphoblastic leukemia, Pemphigus vulgaris patients with mucosal skin involvement had higher median sFas values in contrast to patients with cutaneous involvement., Fas and let-7 microRNAs form a double-negative feedback loop in IFN-gamma and Fas induced apoptosis in colon carcinoma cell line HT29, which may be an important synergistic mechanism in anti-tumor immune response., This repor demonistrated that one SNP (rs7085850) and two haplotypes that were significantly associated with treatment resistant schizophrenia., Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells., Findings show that the oncogenic PI3K/Akt signalling pathway participates in maintaining cells in a type II phenotype by excluding CD95 from lipid rafts., These results suggested that the FAS polymorphisms may contribute to PCa risk in a Chinese population., an essential role of calmodulin in mediating Fas-induced FADD-independent activation of Src-ERK signaling pathways, which promote survival signaling in pancreatic cancer cells., Flow cytometry was used for detection of pSTAT5 and CD95 expression in CD4+ T lymphocytes treated with recombinant human EPO., found the A allele of c.-436C>A (rs9658676) located in the promoter region of FAS to be significantly associated with protection from severe childhood malaria, Fas showed moderate parent-of origin effects for some single nucleotide polymorphisms in attention deficit disorder with hyperactivity., This study determines if Fas/FasL regulates E. coli-induced human monocyte line U937 cell apoptosis., The levels of serum insulin, sFas were raised and sFas-L were decreased significantly in type 2 diabetes subjects than healthy., Our results suggest that deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3, Data indicate that the induction of apoptosis appears to occur through the upregulation of Fas/FasL and Bax, downregulation of Bcl-2., The activation of Fas/FasL pathway may play an important role in the K562 cell apoptosis induced by diallyl disulfide., The Ret oncoprotein exerts opposing controls on Fap-1 and CD95, increasing Fap-1 expression and decreasing CD95 cell surface expression., Data show that Fas-mediate events are mediated by ERK/JNK MAPKs which subsequently activate NF-kappaB for the transcriptional activation of pro-inflammatory mediators., Markers of apoptosis, as measured by sFAS, were found to be independent risk predictors for death in patients with atherosclerotic disease in the carotid arteries., Co-clustering of lipid rafts and Fas/CD95 signaling provides a new insight in the regulation of death receptor-mediated apoptosis, opening a new avenue in cancer therapy., Overexpression of gastrokine 1 in gastric cancer cell lines stimulates the expression of the Fas receptor., data suggest that this FAS mRNA mutation may play an important role in the pathogenesis of Systemic Lupus Erythematosus.(FAS), PMLRARalpha binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo., The polymorphisms of FAS and FASL may be associated with the presence and severity of lumbar disc degeneration in Chinese Han population., Downregulation of Fas receptor and up-regulation of Fas ligand appear to be an important feature of tobacco-related intraoral carcinoma., These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines, FAS 670G/G genotype was more frequent in high risk atrophic gastritis when compared to controls., No statistical association is found between Fas, FasL and TRAIL polymorphisms and the risk of multiple sclerosis in Iranian patients., HIF-2alpha potentiates Fas-mediated chondrocyte apoptosis, which is associated with OA cartilage destruction., Apoptosis-related gene Fas (CD95) and FasL (CD178) polymorphisms in Iranian rheumatoid arthritis patients are more frequent than in controls, although this is not statistically significant., Autoimmune lymphoproliferative syndrome related to TNFRSF6 mutations., Fas and FasL mediated alveolar macrophage apoptosis in human silicosis., results demonstrate that the H204 residue is responsible for c-FLIP(L) binding to CaM, which mediates the anti-apoptotic function of c-FLIP(L), Elevated Fas/FasL system and endothelial cell microparticles are involved in endothelial damage in acute graft-versus-host disease., Functional polymorphisms in the apoptotic pathway genes FAS and FASL may significantly contribute to the occurrence of gastric cardia adenocarcinoma., neither Fas transmembrane domain membrane organization nor its conformation is affected by ceramide, The present results suggest that FAS -670 polymorphism seems to be associated with susceptibility to HTLV-1 and may increase the chance to develop HTLV-1 infections., Abnormal expression of Fas/FasL and increased apoptosis of tumor infiltrating dendritic cells in endometrioid adenocarcinoma may lead to tumor immune escape., Serum Fas was elevated in hypertensive patients with left ventricular hypertrophy compared to non-hypertrophy patients. Serum PIIINP was associated with Fas and TNF-R1; PINP was also associated with these cytokines., This review discusses apparent contradictions of CD95-mediated cell signaling in cancer. [review], CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) beta2, and prevents death-inducing signaling complex formation., Fas immunoreactivity was strong in the TCCB cell line T24 and in 17/20 (85%) tumor samples from patients with advanced TCCB., Functional variant in the core promoter of the CD95 cell death receptor gene is associated with acute promyelocytic leukemia., The interaction of LC3B and Fas pathways requires cav-1., Report induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells., Fas promoter hypermethylation plays an important role in the pathogenesis of bladder urothelial carcinoma and may serve as a prognostic indicator., Evolution of soluble forms of CD86, CD95 and CD95L molecules in liver transplant recipients., Data show that a higher expression of FAS receptor, FAS ligand, TrailR1 and TrailR2 on T cells or blasts of acute myeloid leukemia (AML) patients is associated with a better prognosis., miR-20a, encoded by miR-17-92, downregulates Fas expression in osteosarcoma, thus contributing to the metastatic potential of osteosarcoma cells by altering the phenotype and allowing survival in the FasL(+) lung microenvironment., High IL-7 concentration can prime resting B cells to CD95-mediated apoptosis via an indirect mechanism., Data indicate a critical role for FAS/FAS-L ligation in responder T cell-induced monocyte killing since responder T cells, but not Tregs, upregulate FAS-ligand (FAS-L) and FAS expression on monocytes., PINCH mRNA overexpression in colorectal carcinomas is correlated with VEGF and FAS mRNA expression, Apoptosis markers sFas, FasL or sFas/FasL ratio are associated with high sequential organ failure assessment score (SOFA) in bacteremia., Results indicate that FAS-FASL-CASP8 polymorphisms contributed to a reduced risk of childhood lymphoblastic leukemia (ALL) in Chinese population., non-death domain FAS mutations result in reduced lymphocyte apoptosis, established a hierarchy of genotype-phenotype correlation among mutation-positive relatives of patients with autoimmune lymphoproliferative syndrome., FasL might play a crucial role in other fibrosis-complicated ILDs, like NSIP and asbestosis, Data show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway., We found a trend for association of lupus erythematous and the homozygous A genotype of the functional -670 A/G SNP in the FAS promoter., We provide the first direct evidence that massive liver cell death can be caused by Fas/Fas ligand (FasL) interaction provided by natural killer cells activated by dendritic cells., the Fas and Fas-L mRNA expression levels in BGSCs were lower compared to those in primary cultured glioma cells, Genetic polymorphism -670A>G of Fas gene was associated with significant fibrosis and cirrhosis in chronic hepatitis C patients., CASP8-652 6N DD genotype may play a role in coal worker pneumoconiosis development and interact with SNPs of FAS-1377, FAS-670 and FASL-844., CD95 signal transduction was not affected by FAP-1 expression in A818-6 monolayer cells; we found a polarisation-induced co-localisation of CD95 and FAP-1., In a case-control study the contribution of FAS -1377 G>A and FAS -670 A>G polymorphisms to the risk of recurrent early pregnancy loss (REPL) was evaluated., Suggest that pronounced Fas expression is a surrogate biomarker of active cancer cell proliferation in renal cell carcinoma., Compared serum sFas and p53 protein with that of serum CA 15-3 as the most commonly used breast cancer tumor marker. Serum samples were from breast cancer patients before surgery, 2 weeks after surgery and after six cycles of FAC chemotherapy., The -346T polymorphism of the SH2D1A gene is a risk factor for development of autoimmunity/lymphoproliferation in males with defective Fas function., miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS., 5-azacytidine and decitabine revert DNA hypermethylation in mast cells & lead to demethylation of the FAS promoter and thus to FAS expression., A subset of mutant SOD1 motoneurons shows exacerbated sensitivity to activation of the motoneuron-specific Fas/nitric oxide pathway., Fas has a pro-apoptotic role in photoreceptors. Under light stress, soluble and membrane-bound FasL can bind to Fas, inducing apoptosis via a paracrine mechanism, these data indicate that Fas signaling may induce EMT to promote tumor motility and metastasis in GI cancer in vivo and in vitro., In summary, the Fas/FasL pathway involved in alveolar epithelial cell apoptosis could be important in the pathogenesis of seawater-induced acute lung injury, apoptotic execution is dependent on cell cycle phase and Fas-mediated apoptosis preferentially occurs at G(1) phase., meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk, Data indicate that oligomerization of CD95L has no major effect on CD95 occupancy., CD95 upregulation plays a possible contributory role, together with CD95-mediated apoptosis to lymphopenia, in ataxia telangiectasia patients., canonical NF-kappaB is a Fas transcription activator and alternate NF-kappaB is a Fas transcription repressor, and Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma., Fas expression was lower in pancreatic neoplasms, negatively correlating with perineural invasion., The hedgehog pathway gene SNPs studied, along with the Vitamin D Receptor and FAS SNPs studied, are not strongly associated with the Basal cell carcinoma cancer-prone phenotype., analysis of stoichiometry of the CD95 death-inducing signaling complex and demonstration of how procaspase-8, procaspase-10, and c-FLIP form DED chains at the DISC, enabling the formation of dimers and efficient activation of caspase-8, It was shown that TRPM7 regulates endocytic compartmentalization of the Fas receptor after receptor stimulation, an important process for apoptotic signaling., Dexamethasone upregulates the apoptotic gene expression of Fas/FasL in human articular chondrocytes., levels of serum Fas and FasL in schizophrenic patients, Plasma concentrations of Fas receptors and Fas ligands tend to be higher in HIV-positive patients., A missense mutation in the extracellular domain of Fas is the most common change in Argentinean patients with autoimmune lymphoproliferative syndrome and it represents a founder effect., Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis, RNAi-mediated silencing of STAT1 in soft tissue sarcoma (STS) cells was sufficient to increase expression of the apoptotic mediators Fas and Bad and to elevate the sensitivity of STS cells to Fas-mediated apoptosis, These results represent the first evidence indicating that the two death receptors, Fas and P2X7R connect functionally via caspase-8 and pannexin 1 hemichannel-mediated ATP release to promote caspase-9/caspase-3-dependent cell death in lymphoid cells., analysis of Fas mediated caspase-8 independent apoptosis in human and mouse immune cells by Armigeres subalbatus saliva, Non-small-cell lung cancer patients carrying XRCC1 Arg194Arg, FAS-1377GG, and FASL-844T allele displayed completely no response to platinum based drugs., presence of strong myoepithelial expression of Fas and simultaneous cytoplasmic and nuclear expression of FasL in epithelial cells could be suggestive as an early predictive factor or signal for onset of breast cancer, Besides cell-to-cell interaction-mediated Fas triggering, stimuli induced by secreted vesicles can mediate important additional cell death signals regulating activation-induced cell death under physiological conditions., Relations between sFas/sFasL, MMPs and TIMPs indicate the potential role of metalloproteinases in the sFas/sFasL regulation., Among the genes affected by FAK or HAS3 inhibition were genes, playing role in apoptosis, cell cycle regulation, adhesion, transcription, heatshock and WNT pathways., findings suggest that the Fas -670A/G gene polymorphism is not associated with type 1 diabetes in the Agean region of Turkey., study presents a novel death domain mutation in the FAS gene associated with in utero and early neonatal onset autoimmune lymphoproliferative syndrome, T-lymphocyte activation by drugs in toxic epidermal necrolysis patients may indirectly lead to FasL-mediated keratinocyte apoptosis, via a molecular bridge involving TNF-alpha, IFN-gamma, and iNOS., Myocardial Fas protein expression increased significantly in patients with dilated cardiomyopathy., Fas was expressed more strongly in well-differentiated cutaneous squamous cell carcinomas than in poorly differentiated tumors., This meta-analysis demonstrates that the FAS -670 A/G polymorphism confers susceptibility to rheumatic diseases in Asians., the Fas -670A/G and Fas -1377G/A polymorphisms are associated with SLE susceptibility., FAS was intensely expressed in both biliary cells and hepatocytes in liver failure., Fas-mediated apoptosis is promoted by suppressor of cytokine signaling (SOCS)1 overexpression and suppressed by SOCS1 ablation in T cells., FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor., Our data point to a novel regulatory network comprising p53, CD95, let-7, and miR-34a that affects cancer cell survival, differentiation, and sensitivity to apoptotic signals., Elevated Fas expression in circulating natural killer cells is associated with gastric cancer., Functional polymorphisms in the Fas and FasL genes may be involved in epithelial ovarian cancer development and progression in northern Chinese women., Data show that alterations of the apoptosis-related protein Fas is common in granulosa cell tumor (GCT), and suggest that loss of Fas expression might play role in the pathogenesis of GCT, possibly by inhibiting apoptosis., LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion., Suggest the involvement of the CD95/CD95L pathway in phagocytosis-induced cell death of monocytes and provide evidence that diminished CD95L secretion by cord blood monocytes may result in prolonged activation of neonatal immune effector cells., expression of Survivin was negatively correlated with that of Fas (r = -0.517, p < 0.01), but positively correlated with that of FasL (r = 0.381, p < 0.01) in tissues of cervical cancer, In 101 rheumatoid arthritis patients vs 105 controls, there was no significant difference in FasL-843 C/T genotype distribution and allele frequency., Studies indicate that the anti-apoptotic protein c-FLIP is an important regulator of death receptor signaling, including TNFR1, Fas, DR4, and DR5., Data indicate that FAS rs1800682, FASL rs5030772, and FASL rs763110 polymorphisms were associated with the risk of breast cancer in the examined population., Serum sFas could be considered a possible marker of advanced fibrosis both in pediatric and adult patient with chronic hepatitis C as well as M30 might be a good predictor of steatosis severity in children., Therefore, the optimization of the FasL conformation has to be considered for the development of efficient FasL-derived anti-cancer drugs targeting Fas., Fas and NF-B play a role in the initiation and development of breast cancer., Tregs, but not Th17 cells, become apoptotic through Fas/FasL pathway, which contributed to reduction of Tregs leading to an imbalance between Th17 and Treg cells., In summary, chemotherapy regulates FAS soluble fractions in vitro and in vivo, but does not predict survival in advanced colorectal cancer patients undergoing third-line therapy with the combination of cetuximab and irinotecan., HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes, MSA-associated neurodegeneration is associated with FAS expression in oligodendrocytes displaying early GCI lesions along with astrocytes and microglia., These findings suggest that the Fas-1377 G>A polymorphism in the Fas gene related with apoptosis may contribute to susceptibility to knee osteoarthritis in the Turkish population., Suggest that the FAS-L gene polymorphism is associated with RPL in Brazilian women and that these women also have impaired FAS-FAS-L systems due to abnormal FAS-L expression., hnRNP A1 interacts with exon 5 to promote distal exon 6 inclusion of Fas pre-mRNA., Fas-induced production of MCP-1 and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells., siRNA knockdown of XIAP enhances Fas-mediated apoptosis., CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with beta-catenin., Results suggest that FAS haploinsufficiency does not cause autoimmune lymphoproliferative syndrome (ALPS)-FAS, but that modifying genetic events are crucial for its pathogenesis., Data indicate that FAS-1377G/A and FASLG-844 T/C genotypes are likely to play a substantial role in HBV infection, and FAS-670 polymorphism is associated with chronic HBV infection, while FASLG IVS2nt-124 A/G polymorphism is not., FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas., This is the first study presenting sFas and FasL concentrations in early second-trimester amniotic fluid in appropriate for gestational age , small for gestational age, and large for gestational age fetuses., Data indicate that Fas signalling inactivates GSK-3beta by ERK/MAPK signalling, leading to nuclear accumulation of Snail and beta-catenin., Results suggest that the Fas signal favors the Th17-phenotypic features of T cells through the caspase-1/Stat3 signaling pathway., This study determined the interplay between NF-kappaB and Fas during myelodysplastic syndromes progression., Neither FAS-1377G > A nor FAS-670A > G genetic variants showed statistically significant impact on individual's susceptibility to laryngeal and hypopharyngeal squamous cell carcinoma in the Chinese population., reduced levels in the bronchoalveolar lavage fluid of smoking patients with sarcoidosis, this meta-analysis suggests that the FAS-1377 G/A polymorphism is associated with susceptibility to gastric cancer, especially in Asians, crosstalk between JNK and Fas pathway in radiation-induced apoptosis, Data indicate that cysteine cathepsins are not required for the TRAIL- and CD95-mediated apoptosis in various human cancer cell lines., there were no associations of CD95 A670G and CD95L T844C polymorphisms with gastric cancer., Semiquantitative analysis of the pattern and distribution of the Fas antigen and Fas Ligand as indicators for hepatic apoptosis was studied and assessed., the Fas-670 A>G gene polymorphism may be associated with disease progression in rheumatoid arthritis., Fc gamma receptor controls the fas-dependent regulatory function of lymphoproliferative double negative T cells., Data suggest that autoimmune lymphoproliferative syndrome [AL(L)PS] may be associated with nonsense mutation in exon 9 of Fas gene; young woman with AL(L)PS and her father (with previous diagnosis of lymphoma) exhibit the same mutation. [CASE REPORT], carriage of IL-6 high producer/Fas low producer genotype has a protective effect against renal graft function loss, the reduced expressions of Fas and Bcl-2 proteins in CD14+ monocytes from juvenile systemic lupus erythematosus patients depict that monocyte apoptotic mechanisms may be important in lupus pathogenesis., lack of association of the Fas rs180082 polymorphisms with cervical cancer susceptibility [meta-analysis], TNF-alpha-induced cell death in senescent endothelial cells is due to expression of FAS receptor, our results correlate a negative FAS/FASL expression with worse prognosis in oral squamous cell carcinoma patients, suggesting that these proteins play important roles in oral cancer cell apoptosis., Studies suggest that there is no association between FAS A670G polymorphism and susceptibility to cervical cancer in both Caucasians and Asians., increased blood concentrations of biomarkers VCAM-1, soluble Fas and hepatocyte growth factor, separately and in combination, associate with mortality among the aged and are prognostic markers of death, These findings indicate that sFas and sFasL might play a role in intervertebral disc degeneration., Soluble serum levels of FAS do not differ among multiple sclerosis patients and healthy controls., CD95/CD95L plays a role as anti- or pro-tumor signaling pathway according to the cell lineage or tumor staging., urinary sFas levels were significantly higher in cases with a higher stage or grade or high-risk and recurrent non-muscle-invasive bladder cancer than in those with a lower stage or grade or low-risk and nonrecurrent disease, This work reveals that polymorphisms of FAS -1377G/A and FASL -844T/C but not FAS -670A/G are associated with risk of neuroblastoma in Chinese., FAS 1377G>A polymorphism is significantly associated with increased susceptibility to breast cancer in Asians., The FAS-1377 G/A SNP may decrease cancer risk. Studies with larger samples to study gene-environment interactions are warranted to understand the role of FAS gene polymorphisms, especially -1377 G/A SNP, in cancer risk., A patient carries mutations in the FAS, XIAP, and UNC13D genes, and his healthy father exhibits defective FAS function., Data suggest opposing paths of interference in apoptosis of placental trophoblasts infected with Toxoplasma gondii strains differing in virulence is due to different cytokine secretion and expression of Fas/CD95 and phosphorylated MAP kinases ERK1/2., Asymmetric dimethylarginine treatment of colon adenocarcinoma cell line, attenuated serum starvation-induced apoptosis and suppressed the activation of the Fas (APO-1/CD95)/JNK pathway., There is an association of the FAS and FASL gene variants in the promoter regions with primary brain tumors in the Turkish population., meta-analysis suggests that CD95 rs1800682 polymorphism is not associated with cervical cancer risk., Independently of body weight, increased Fas expression may contribute to impaired insulin sensitivity and aipose tissue dysfunction in obesity., This meta-analysis suggests that the FAS-1377 A/G polymorphism is likely to be associated with the risk of breast cancer, These data suggest that plasma transglutaminase factor XIII may play a key role in fetal development of vertebrates via cross-link of Fas antigen., No contribution of Fas genotypes at positions -670 and -1377 to risk of ALL in children., FasL-Fas network might play an important role in the molecular mechanisms of angiogenesis prevention of human intervertebral discs., In patients with acute STEMI, sFas apoptosis levels were increased. Fas levels were associated with high plasma glucose., observed that the FAS-1377G/A and FASL-844C/T polymorphisms were associated with breast cancer risk in Chinese but not whites, Rheumatoid arthritis B cells had reduced Fas expression compared with their healthy counterparts and were resistant to Fas-mediated apoptosis., Study results confirmed the dynamic pattern of sFas/APO 1 in serum and cerebrospinal fluid of patients with acute ischemic stroke, suggesting the possible role of apoptosis in the pathogenesis of cerebral infarction., Antagonizing miR-128a expression sensitized Jurkat/R cells to the Fas-mediated apoptosis through derepression of FADD expression., S-glutathionylation of Fas in lung epithelium enhances epithelial apoptosis and clearance of P. aeruginosa. Glutaredoxin-1 impairs bacterial clearance and increases severity of pneumonia in association with deglutathionylation of Fas., Fas/FasL signaling promotes the development of human silicosis by regulating the expression and release of inflammatory cytokines., Polymorphisms in FAS and FASL genes are not associated with HBV infection in the Brazilian Amazon region., we found an association between AA genotype of FAS A-670G polymorphism and CC genotype of FASL C-844T polymorphism with SLE risk., Fas 1377G > A polymorphism and FasL 844 T > C polymorphism are both not associated with susceptibility to cervical cancer, Downregulation of Fas was observed with human cytomegalovirus strains AD169, FIX, Merlin and TB40., FAS mutations have a clinical penetrance of <60% in autoimmune lymphoproliferative syndrome-FAS., We investigated the association between common polymorphisms in the genes for FAS and FASL and the risk of late side effects after radiotherapy for prostate cancer., the association of diplotypes of common rs1800682G and rare rs34995925C alleles within the STAT1 transcription binding site of the FAS promoter region with preeclampsia, Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels., Fas cytoplasmic expression did not independently influence pancreatic cancer patient's prognosis., Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner, Fas-Fas-ligand signal transduction could be inhibited, especially at the stage of caspase-8 activation, thereby establishing a major mechanism for evasion of apoptosis by these tumors, the role of FAS polymorphisms, especially rs2234767G/A, in cancer risk (Review; Meta-Analysis), We identified different SNP markers that correlated with increased risk of organ-specific graft vs host disease (for example, FCGR2A SNP for oral GVHD, and FAS and TGFB1 SNP for lung GVHD)., Carriers of the Fas-1377A and the FasL -844C are more susceptible to the majority of cancers than non-carriers. [Meta-analysis], Report Fas/FasL mutations in T-cell lymphoblastic lymphoma., Therefore, blockade of Fas signaling can suppress breast cancer progression by inhibiting proinflammatory cytokine production and MDSC accumulation, indicating that Fas signaling-initiated cancer-related inflammation in breast cancer, Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death., data indicated a possible linkage between the FAS and FASLG genes and idiopathic azoospermia, FAS A-670G polymorphism is associated with a higher risk for Pre-eclampsia (PE). There was no association between FAS Ligand C-844T polymorphism and PE., Upregulation of Fas in epithelial ovarian cancer reversed the development of resistance to Cisplatin., Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors., High Fas expression in gastric carcinoma cells as a factor correlating with the occurrence of metastases to regional lymph nodes., the Fas -670 A/G polymorphism might decrease the hepatocellular carcinoma risk in Asian populations (Meta-Analysis), Fas/FasL interaction mediates keratinocyte death in sunitinib-induced hand-foot skin reaction, EWS promotes exon 6 inclusion and consequently the synthesis of the proapoptotic FAS/CD95 isoform, whereas an EWS-FLI1 fusion protein characteristic of Ewing sarcomas shows decreased activity., FAS-1377 G and FASL-844 T alleles may be used as low-penetrant risk factors for bladder cancer development in a Turkish population., Defective Fas signaling leads to aberrant transcription and differentiation of CD4 and CD8 T cell subsets. Accumulation of these cells before their double-negative state is an early event in lymphoproliferation in autoimmune lymphoproliferative syndrome., Further analysis demonstrated that PARP inhibitor treatment results in activation of the FAS and TNFRSF10B (death receptor 5 (DR5)) promoters, increased Fas and DR5 mRNA, and elevated cell surface expression of these receptors in sensitized cells, Data suggest that Fas polymorphisms are likely to affect breast cancer risk by regulating the soluble Fas concentration., Fas/FasL signaling pathway of the lung microenvironment participates in the development of osteosarcoma lung metastases. (Review), The Fas/FasL pathway might play an important role in excessive hematopoietic cell apoptosis in severe aplastic anemia bone marrow., The presence of the Fas gene polymorphism Fas A670G is associated with an increased risk of preeclampsia, while the presence of FasLG IVS2nt 124 A>G gene may be protective against preeclampsia., biliary tree stem/progenitor cells could modulate the T cell response through the production of FasL, which influences the lymphocyte Fas/FasL pathway by inducing "premature" apoptosis in CD4(+) and CD8(+) T cells, a key role of MK2 and FasR in the regulation and limitation of the immune response in the CNS, Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD95., This work reveals a novel mechanism of memory B cell apoptosis mediated by LPS and HIV through the Fas/FasL pathway., The soluble Fas levels in the serum of Sjogren's syndrome patients were significantly higher than in controls., Fas sensitivity was reduced in the MCF10A breast cells expressing the FAIM2 beta-isoform., Stimulation of CD95 could promote rheumatoid arthritis fibroblast-like synoviocyte proliferation and inflammation, Fas -670 A/G (rs1800682) polymorphism is associated with esophageal cancer, hepatocellular carcinoma, and prostate cancer., Data suggest that tumor protein 53 (P53) single nucleotide polymorphisms (Pro/Pro and Arg/Arg) and apoptotic antigen-1 gene (APO-1) A/A genotypes may be potentially used as sensitive genetic markers for hepatitis C virus genotype 4a susceptibility., Study indicates that Piwil2 plays a role in Fas-mediated apoptosis and can affect p53 phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supports that Piwil2 plays an active role in tumorigenesis., The gene expression analysis showed statistically significant difference between cases and healthy controls for both FADD (p<0.02) and FAS (p<0.007) genes, The G allele of the c.-671A>G polymorphism was associated with increased occurrence of Fuchs endothelial corneal dystrophy, while the A allele was associated with decreased FECD occurrence., Up-regulation of Fas-L and cell surface localization of FAS induced by PEDF is mediated by p53., TRAF2 acts as an antagonist of TRAIL- and CD95L-induced necroptosis., Specific targeting of the CD74 on the lymphoma cell surface will sensitize CD74-expressing cancer cells to Fas-mediated apoptosis., FaS/ FaSL and HGF did not differ significantly in chronic viral hepatitis C patients and controls, Cancer stem cells are less sensitive to canonical apoptosis induced through CD95 than non-cancer stem cells., Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation., data show that the expression of CD200R, CD95 and CD95L was influenced by cardiac surgery and imply the role of these membrane molecules in cell regulation-inhibition and apoptosis following cardiac surgery., IL-7 elevates miR-124 to decrease the expression of splicing regulator PTB and represses CD95 mRNA splicing., Up regulation of FAs ligand proteins may induce plant alkaloids treated cell apoptosis of HepG-2 cells., data indicate upregulation of the sFas/sFasL system in psoriatic patients., hepatitis B virus suppressed apoptosis of hepatoma cells by up-regulating miR-181a expression and down-regulating Fas expression, which may provide a new understanding of the mechanism in HBV-related hepatocellular carcinoma pathogenesis., Docosahexaenoic acid counteracts the negative effect of mercury on CD95 signaling in T lymphocytes., Genome-wide identification of CD95 antigen alternative splicing regulators reveals links with iron homeostasis., Serum and follicular fluid Fas levels were decreased in female infertility patients., Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway., High levels of sFas is associated with rheumatoid arthritis., These results indicated that CD95 was associated with liver cancer and promoted the apoptosis of liver cancer cells by caspase8, caspase3 and PARP1., FasL -844 SNP is associated with the susceptibility of pulmonary AD in age <60 years people. Fas -1377 SNP may modify the association of FasL -844 SNP with the risk of pulmonary adenocarcinoma., Results suggest that the up-regulation of MIR196B modulates apoptosis in colorectal cancer cells by partially repressing FAS expression., Expression of CD95 increases in primary pancreatic ductal adenocarcinomas (PDAC) as compared with non-tumour-bearing pancreas & is higher in metastatic pancreatic cells than in primary PDAC. Neutralization of CD95L reduces PDAC growth & metastasis, genetic polymorphism is associated with rheumatoid arthritis, meta-analysis, Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy., NF-kappaB can mediate Fas-induced apoptosis through caspase-4 protease, CD95 can be recruited to rafts in a reversible way through S-palmitoylation following activation of cells with its physiological cognate ligand as well as with a wide variety of inducers. [Review], NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity., The CD95 rs1800682A/G site polymorphism may be associated with hepatocellular carcinoma susceptibility., The expression of two proapoptotic genes, FAS and DR5, was significantly lower in tumor samples than in adjacent normal tissues, The FAS-670 GG genotype may increase the risk of Alzheimer's disease in the younger population (age, B65 years)., There was a significant association between SNPs of the Fas gene and the development of papillary thyroid cancer (PTC). In addition, there was a significant association between a Fas SNP and the multifocality of PTC., In addition to LFA-1, this work reveals a second surface protein, Fas, that is critical for LtxA-mediated cell death., analysis of the expression of TLR-9, CD86, and CD95 in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy, Results show that gemcitabine sensitizes pancreatic cancer cells to the cytotoxic T lymphocytes antitumor response, and the sensitization is associated with upregulation of Fas on pancreatic cancer cells., Downregulation of FLIP Levels Annuls hTERT-Mediated Resistance to Fas-Induced Apoptosis in Human Lung Epithelial A549 Cells., Latent HCMV infection of CD34 + cells protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway., we developed a method that enables a quantitative detection of different CD95 signaling pathways in the single cell., Findings suggest that FAS rs1800682 and FASLG rs763110 variants modulate the risk of recurrence of squamous cell carcinoma of the oropharynx, particularly in patients with HPV16-positive tumors., The activation of Fas signaling promoted cell migration and resulted in STAT3-dependent Fascin upregulation in AGS gastric cancer cells., Down regulation of MCT1 promote the sensitivity to cisplatin in ovarian cancer cells. This effect appeared to be mediated by antagonizing Fas., Our findings suggest that a high copy number of FAS gene confers risk for BD and VKH syndrome., preliminary report associates FAS -670A>G genetic polymorphism with Treatment Resistant Depression and with time to relapse, Data show that calcium entry exerted a negative feedback loop on CD95-dependent rituximab-induced apoptosis, and that calcium channel Orai1 inhibition greatly reduced tumor growth., the role of lipid rafts in Fas/CD95-mediated apoptotic cell signaling in hematologic cancer cells and normal leukocytes, stichoposide D inhibits growth of experimental leukemia by activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Three cases of autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline CASP10 variation have been described., These findings demonstrate highly dynamic Lck palmitoylation kinetics that are essential for signaling downstream of the Fas receptor., Initial sFas plasma levels in patients with sepsis correlated with the values of APACHE II score and separated the patients with septic shock versus the normotensive patients, the patients with and without MODS, and survivors versus nonsurvivors., FAS -670 A/G polymorphism may be associated with the depletion of CD4(+) T lymphocytes in HIV-1 infection., TCERG1 sensitizes a cell to apoptotic agents, thus promoting apoptosis by regulating the alternative splicing of both the Bcl-x and Fas/CD95 genes., Agonist mobility on supported lipid bilayers affects Fas mediated death response, Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG)-Fas protein axis to promote apoptosis resistance in pancreatic cancer., haploinsufficiency contributes to the pathogenesis of Autoimmune Lymphoproliferative Syndrome caused by mutations in extracellular domains, Fas/FasL system and downstream activation of caspases are important mediators of apoptosis and may be involved in the pathogenesis of pulmonary edema in severe P. falciparum malaria patients., Abnormal Fas/FasL expression in gastric cardia carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer., Frequencies of SNPs rs2234978 and rs1045487 of FAS and CASP8 genes were significantly higher in Autoimmune Lymphoproliferative Syndrome patients., Data determined the transmembrane domain structure of Fas and showed that the trimer assembly, which is mediated by a proline-containing motif, is essential for Fas signaling providing structural explanation for many known cancer mutations in this domain., These results suggested that FAS/FASL polymorphisms might significantly modify SPM risk among patients with SCCHN in a tumor site-specific manner., Dephosphorylation of Fas tyrosines by SHP-1 tyrosine phosphatase turns on the pro-apoptotic signal whereas the tyrosine phosphorylation by Src family kinases turns off the pro-apoptotic signal and turns on the pro-survival signal., Meta-analysis, Renal CD95 expression is decreased in diabetes., A review of alternative spliced APO-1 variants and their possible biological roles., These results suggest that irradiation induces direct apoptosis of T cells by a Fas-independent mechanism.,
OMIM_DISEASE Autoimmune lymphoproliferative syndrome, Autoimmune lymphoproliferative syndrome, type IA, Squamous cell carcinoma, burn scar-related, somatic,
SP_COMMENT disease:Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly., domain:Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins., function:Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)., online information:Mutations in TNFRSF6 causing ALPS type Ia, similarity:Contains 1 death domain., similarity:Contains 3 TNFR-Cys repeats., subunit:Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B., tissue specificity:Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.,