Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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insulin like growth factor 1(IGF1) insulin like growth factor 1(IGF1) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q22-q23,
ENSEMBL_GENE_ID ENSG00000017427,
GENERIF_SUMMARY transcription is regulated by the PAX3-FKHR oncoprotein, Hypothyroidism is associated with significant reductions of IGF-1, induces Pin1 expression in promoting cell cycle S-phase entry, IGF-I level was significantly lower in the CDGP (constitutional delay of growth and puberty)group, Protein kinase C-dependent, CCAAT/enhancer-binding protein beta--mediates expression of IGF-I, Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture., lower IFG-I concentrations correlate with higher bone resorption markers values and decreased mineralisation, Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells., role for IGF-I in the regulation of the MDM2/p53/p21 signaling pathway during DNA damage, Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression., study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention, IGF-I may promote granulocyte functions by increasing granulocyte longevity, assess the levels of IGF1 during pregnancy and to determine whether or not low concentrations are associated with fetal untrauterine growth retardation, The insulin-like growth factor-I gene cytosine-adenine polymorphism relates with circulating insulin-like growth factor-I levels and bone mineral density at the lumbar spine and proximal femur., IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1., is essential for normal growth and mutations are associated with extreme growth retardation in mice and humans and the relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question, Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease., Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly., plays an important role in the genetic and perhaps nutritional determination of adult stature in humans, In demonstrating transduction of fascin spike assembly by activation of a peptide growth factor receptor, these novel data reveal a wide role for fascin spikes in cell motility, Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke, RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death., Extravillous cytotrophoblast differentiation requires at least two distinct steps, IGF-1 inscribes a gene expression profile relevant to cancer progression, cDNA probes were used to analyze the gene expression of IGF-I in luteinized granulosa cells from different-sized follicles after ovarian hyperstimulation., determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation, IGF-I protects the cells from apoptosis by blocking the activation of caspases, which may be responsible for the loss of FAK and Akt., Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China., results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3, Polymorphism in the IGF-I gene, insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch, IGF1 mediated AKT activation delays radiation-induced apoptosis, allowing the DNA repair mechanism more time to remove cyclobutane thymine dimers., A putative functional polymorphism associated with NIDDM, adult height, glucose tolerance and fetal growth, MGF inhibits terminal differentiation and increase cell proliferation of myoblast (mechano growth factor), Elevated levels of IGF-1 is associated with pleural effusions of solid tumors, is positively associated with benign prostatic hyperplasia risk, Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer., Autocrine production of IGF-I and IGF-II may via IGF-IR play a significant role in the growth and megakaryocytic differentiation of K562 cells., circulating levels of IGF-1 and IGFBP-1 are significantly related to the extent of myocardial injury in patients with hypertrophic cardiomyopathy., structural origins of the functional divergence with insulin, Insulin-like growth factor-1 and myostatin mRNA expression in muscle, The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain., Maternal nitrogen balance in the regulation of circulating levels of insulin-like growth factor-I in human pregnancy., improves insulin resistance by GH-dependent and independent mechanisms, IGF-I does not affect the net increase in GH release in response to arginine., The biological relevance of this finding is suggested by the significant association between local IGF-I mRNA levels and microvessel density in the colorectal cancers., IGF1 has a role in producing extracellular matrix components in human umbilical cord serum and tissues, Circulating levels of insulin-like growth factor-I and risk of ovarian cancer, GH-IGF-I axis in non-obese women with functional hyperandrogenism., H358 cells secrete a high level of amphiregulin that, in combination with IGF1, prevents serum deprivation apoptosis, Insulin-like growth factor I causes nuclear accumulation of cyclin D1 in tumor cell lines, Intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals., Glucose transporter gene expression in the jejunum in response to insulin-like growth factors in rat pups, Serum levels of insulin-like growth factor-1 and insulin-like growth factor-1 binding proteins after radical prostatectomy, IGF-1 induces a transient increase followed by a decrease of CCE, and that these effects are at least partly dependent on IGF-1-induced K(+) channel activity., Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. IGF-I was an independent predictor of muscle function only in lowest IL-6 tertile., analysis of single and double targeted mutagenesis of the gene encoding IGF-I demonstrate its critical role in embryonic development-REVIEW, Correlation between IGF-I and Mini Mental State Examination in Alzheimer's disease suggests a mechanism involving immuno-somatopause in progression of dementia., Above threshold of GH hypersecretion, IGF I levels reach plateau and are no more associated with GH secretion., Reduced IGF I secretion in normal elderly subjects not due to alteration of nutritional status., IGF I levels within 24 hours from stroke onset significantly and inversely related to poor outcome and death. Lower in acute ischemic stroke than in controls., Significant reduction of serum IGF I in centenarians in comparison to normal adults and normal elderly., Data suggest role for IGF I in control of blood pressure in obesity., Decrease of serum IGF-I level may play a role in the cognitive impairment in patients with obstructive sleep apnea syndrome (OSAS)., data demonstrate for the first time that serum levels of IGFs (including free fractions) and IGFBPs are not increased in euthyroid Graves' patients with active thyroid eye disease, REVIEW, regulation of signaling in breast cancer by JN kinase, High resistance exercise resulted in a significant increase in mechano growth factor isoform of IGFI mRNA in young, but not in elderly subjects, Follicular fluid IGF-1 and IGFBP-3 levels were not significantly different among the groups; however, follicular fluid IGFBP-1 levels were lower in those patients with moderate/severe endometriosis, A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. In homozygous carriers of the 192 bp alleles of the IGF-I gene an age-related decline in circulating total IGF-I levels., Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts., results suggest that trunk fat attenuates the hormone replacement therapy-induced increase on growth hormone levels and is a significant determinant of low IGF-1 levels in postmenopausal women, Inhibition of either phosphatidylinositol 3-kinase (PI3-K) or Mek1/2 signaling pathways completely abrogated the IGF-I-induced increase in VEGF secretion and promoter activity, IGF-I induces VEGF gene expression and protein secretion in human mesangial cells via a Src-dependent mechanism., activates p21 to inhibit UV-induced cell death, maternal insulin-like growth factor-I levels, especially during late pregnancy, positively influence birth weight, This study suggests that IGF-I levels below 9.4 nmol/l are negatively associated with both the level and decline of information processing speed, in a prospective study of 3-year cognitive decline in 1318 subjects aged 65-88., Poor glycemic control and differences in IGF-I levels and androgens accompany development of microalbuminuria at puberty; differences may account for sexual dimorphism in microalbuminuria risk during puberty and to disease progression, Levels are altered in diabetic angiopathies., IGF-I isoform a expression may be downregulated at the mRNA level during the initial part of recovery from resistance exercise, combination of low insulin-like growth factor-I and high interleukin-6 levels confers a high risk for progressive disability and death in older women, results indicate that IGF-I-stimulated migration of WM1341D melanoma cells requires phosphoinositide 3-kinase activation but is independent of mitogen-activated protein kinase/extracellular signal-regulated kinase signaling, IGF-1 and OP-1 could be key physiological regulators of MMP-13 gene expression, When IGF-I was added, the reduction in prostate cancer LNCaP cell growth and the induction of apoptosis in medium containing serum alone were reversed., The terminal complement complex inhibits apoptosis in vascular smooth muscle cells by activating an autocrine IGF-1 loop., Hypertensive subjects who have low IGF-I levels because of a genetic polymorphism in the IGF-I gene are at increased risk of developing atherosclerosis, IGF-1 plays a critical role in the desensitization of IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization, possible stimulatory effect of endogenous GH on IGF and IGF-binding protein (IGFBP) levels during fasting., free IGF-I plasma levels and human longevity are coregulated by an overlapping set of genes so the impact of the IGF-I/insulin pathway on longevity is a property that has been evolutionarily conserved throughout the animal kingdom., IGF-I clearly stimulates telomerase activity in prostate cancer cells through a dual mode of action, including early rapid effects probably involving phosphorylation of hTERT by Akt and later up-regulation of hTERT expression., Insulin-like growth factor-1 isoforms in skeletal muscle aging, regeneration, and disease. Review., serum concentrations of insulin-like growth factor binding protein-1 are abnormal in antiphospholipid syndrome pregnancies, Divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in lean body mass in healthy elderly men and women., p21CIP/WAF is a positive regulator in the cell proliferation induced by IGF-I in MCF-7 cells, endurance training may attenuate the aged-related decline in insulin sensitivity and insulin-like growth factor-I, inactivation of FoxO1 by IGF-I plays a critical role in rat skeletal satellite cell proliferation through regulation of p27Kip1 expression, during a short-term energy deficit in young men, IGF-I system components differentially respond to a given metabolic perturbation and the relative proportion of IGF-I sequestered in ternary vs. nonternary molecular complexes appears to be well maintained, insulin-like growth factor 1 promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of bone mineral density levels and rate of bone loss in postmenopausal women., The effects of IGF-I are differentiation dependent and restricted largely to the more mature cells of the osteoblast lineage., IGF-I promoted maturation of cord blood monocyte-derived dendritic cells (DC), IGF-I enhances adhesion via inactivating focal adhesion kinase, IGF-1 prevents age-related decline in peak intracellular Ca2+ and specific force in a muscle that does not exhibit changes in fibre type composition with senescence., role of ERK1 and 2 in mediating IGF-I-stimulated vascular smooth muscle cell proliferation and chemotaxis, growth disorders in this group of children might be due to a defect in a DNA region regulating expression of the growth hormone receptor and insulin-like growth factor 1 genes or genes involved in their regulation., Exercise-associated mechanisms may inhibit increases in IGF-I early in the course of a training protocol, even in overfed subjects., IGF-I signals osteoblast mitogenesis and survival through parallel, partly overlapping intracellular pathways involving PI-3 kinase, p42/44 MAPKs, and G beta gamma subunits., Recombinant human IGF-I increases gap junction communication and connexin43 abundance in primary astrocyte cultures from 2-day-old rats., We conclude that IGF-I plays a dominant role in growth during the perinatal period and that all three studied components of the IGF system are sensitive to liver and kidney function., Haplotype analysis in the Swedish short small for gestational age subjects showed that the region of association lay between the promoter and intron 2 of the IGF-I gene., IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha, Review. IGF-1 exerts multiple physiologic effects on the vasculature, including proliferative, hypertrophic, survival, vasomotor, & metabolic effects. IGF-1 & its receptor & binding proteins & involvement of this system in vascular diseases are reviewed., IGF-I may be a mediator of steroid effect during precocious maturation of the ileal mucosa., study showed decreased levels of serum insulin-like growth factor 1 (IGF-1) and increased levels of growth hormone (GH) in the hypoxic-ischemic (HI) brain of newborns, Cooperation between CTGF and IGF-I might be involved in glucose-induced matrix accumulation in tubulointerstitial fibrosis and might contribute to pathogenesis of diabetic nephropathy., insulin-like growth factor I signaling has a role in neurodegenerative diseases (review), A physiologic intrafollicular dose of IGF-I did not stimulate estradiol production but reduced the production of androstenedione and stimulated the production of activin-A, inhibin-A, and VEGF during follicle selection in mares., The IGF-1 axis is upregulated in prostate carcinoma cells that have resided in bone., progesterone increased local IGF-I bioavailability in malignant breast tissue; this depended on steroid receptor phenotype of breast tissue and was most evident in tissue expressing progesterone receptor, results establish that tumor necrosis factor alpha targets insulin-like growth factor-I induced E2F-transcription facor 1 synthesis, leading to inhibition of accumulation in cyclin A and hyperphosphorylation of RB protein, IGF-I-induced activation of the skeletal alpha-actin promoter is regulated by the L-type VGCC and calcineurin but independent of nuclear factor of activated T-cell transcriptional activity as C2C12 myoblasts differentiate into myotubes., IGF-1 enhances uncoupling protein 3 expression at transcriptional level, primarily through the phosphatidylinositol 3-kinase-dependent pathway and partly through the MAP kinase pathway., Human fat cells protect themselves from apoptosis by IGF-I in an auto-/paracrine manner., IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth., IGF-I-induced PI3K signaling is responsible for IGF-IR mediated attenuation of antineoplastic agent-induced growth inhibition, Sserum IGF-II shows positive correlations with myoblast retrieval in control patients that is lost in malignancy., IGF-I increases expression of VEGF-A in sarcoma and umbilical vein endothelial cells., IGF-I treatment stimulated cell growth and proliferation, but also mildly induces apoptosis in an osteosarcoma cell line., "Growth hormone(GH)regulates IGF-1 gene expression in a variety of tissues, including...liver...and skeletal muscles...effects of GH on IGF-1 gene transcription...depend(s)on GH availability, but also on expression of the GH receptor..." p. 1273, low baseline levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 increase the risk of fatal ischemic heart disease among elderly men and women independent of prevalent risk factors, IGFBP-3 plays a crucial role in regulating IGF-I bioavailability, promoting cell survival., Both first- and second-phase insulin secretion were not significantly different between the various IGF-I or IGF-II genotypes., Insulin-like growth factor-I (IGF-I) is sensitive to nutrient supply in hatching chicks, and fasting reduced IGF-I mRNA levels in muscles of older chickens., no significant differences between normal and reduced bone mineral density for serum IGF-1, In human fetuses, IGF-I and IGF-II levels increase longitudinally throughout pregnancy., Inhibition of E-cadherin function inhibits both IGF-I-dependent cancer cell migration and invasiveness., Data show that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I receptors., Recombinant human IGF-I promotes G1 progression in oligodendrocyte progenitor cells by enhancing FGF-2 induction of cyclin D1, activation of G1 cyclin-cyclin-dependent kinase complexes, and hyperphosphorylation of retinoblastoma protein., Progesterone down-regulates IGF-I mRNA and protein expression in cultured leiomyoma cells without affecting IGF-I receptor mRNA expression., GH and IGF-I can synergize in acute aspects of signaling and IGF-I enhances GH-induced assembly of conformationally active GHRs, Following severe burn, a shift occurs toward a predominant Th2 phenotype. Exogenous IGF-I/IGFBP-3 treatment partially reverses this response., Recombinant human IGF-I increased renal p21 and PCNA expression, but reduced cyclin D1 expression in CDDP-treated kidneys. May ameliorate renal damage, in part by stopping the cell cycle at G1/S phase. Promotes recovery from ischemic renal injury., This review outlines the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of peripheral nerves., Renal cell carcinoma (RCC) expresses IGF-I and IGFBP-3 and is responsive to exogenous IGF-I stimulation. In metastatic RCC, autocrine IGF-I and IGFBP-3 stimulated and inhibited growth. IGF-I and IGFBP-3 possible treatment in advanced RCC., a decrease of insulin-like growth factor 1 along with an increase of hepatocyte growth factor may reflect an underlying biological process that influences cognitive decline as well as carotid atherosclerosis in the elderly, Transgenic IGF-I promotes proliferation of neural cells in the embryonic central nervous system of transgenic mice in vivo and inhibits neural cell apoptosis during postnatal life of the animals., an important role of IGF-I in the pathogenesis and invasiveness of the malignant thyroid neoplasms, IGF-I prevents apoptosis by preventing downstream caspase activation, maintaining Delta Psi(M) and regulating Bcl proteins., P. 445, the functional epitope of IGF-I for IGF-II comprises residues in the N-terminal L1 domain and residues at the C-terminus of the alpha subunit, IGF-II, IGF-I-induced cell cycle progression is regulated by 14-3-3sigma, The C and D domains of IGF-II promote higher affinity binding to the IR-A than the equivalent domains of IGF-I., EPO+IGF-I exert cooperative actions that afford acute neuroprotection via activation of the PI3-K-Akt pathway, IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating mitochondrial membrane potential, possibly by the involvement of UCP3., free IGF-II but not IGF-I may have a role in progression of breast cancer, lower serum IGF-I levels are risk factors for lower bone mineral density in middle-aged Korean men, Association between high IGF-I and IGFBP-3 levels and increased risk of breast cancer in premenopausal women., somatotropin-IGF-I axis contributes to changes in bone density and male reproductive organs., The CA-repeat promoter polymorphism in the IGF-I gene is associated with the risk for fragility fracture at old age in women and with bone structure in both genders., IGF-I may play a critical role in adipocyte differentiation and lipid accumulation., The IGF1 was not associated independently with colon cancer, but there was an association when examined with IRS1. Individuals with an IRS1 R allele and IGF1 non-192 allele were at a 2-fold increased risk of colon cancer (95% CI 1.2-4.4)., DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling, Ceramide, derived both from sphingomyelin and de novo synthesis, is a key intermediate by which proinflammatory cytokines impair the ability of IGF-I to promote protein synthesis and expression of critical muscle-specific transcription factors., evidence suggests that decreased IGF-1 levels and signaling during early development may modulate longevity in many species--REVIEW, Insulin like growth factor I polymorphism is associated with increased risk for heart failure in elderly patients., In a model of severe undernutrition, rhIGF-I and estrogen individually increase ghrelin levels., Long-term use of both conjugated equine etrogens and raloxifene decreases serum IGF-I and the IGF-I/IGFBP-3 ratio, IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle., common wild-type allele of the IGF-I promoter polymorphism is associated with increased levels of fasting serum triglyceride in glucose-tolerant whites, IGF-1 can regulate RUNX2 DNA binding through sequential activation of the PI3K/Pak1 and ERK1/2 signaling cascade, Vitreous samples from patients lacking diabetes or other retinal pathology had undetectable or low activities to IGF1, endogenous expression of SR-BI/CLA-1 was suppressed by exposure to growth hormone or IGF-I in cultured HepG2 cells, Data confirm the involvement of the insulin-like growth factor binding protein (IGFBP)-binding domain on IGF-1 in binding to IGFBP-2 and IGFBP-3 and support involvement of the IGF-1 receptor-binding domain in IGFBP binding., effect on heat shock protein-90 signaling, Thus, in RPE cells IGF-1 stimulates the second messenger Ca(2+) and increases VEGF secretion which, in turn, induces neovascularization., Review. IGF-1 protects against endothelial dysfunction, atherosclerotic plaque development, the metabolic syndrome, clinical instability, and ischemic myocardial damage., IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM-dependent and LKB1-independent pathway, Tumor necrosis factor-alpha was more effective at inhibiting differentiation in subcutaneous cells, whereas insulin-like growth factor-I stimulated differentiation more effectively in visceral cells, contributes toward forming and mineralizing dental tissues as well as in pulp-repairing processes, Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in tumor cells, IGF-I modulates androgen signaling through beta-catenin, Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1., In obese compared with normal-weight healthy subjects, there is a larger increment IGF-I to a single bolus of growth hormone in men amd women., IGF-1 may play a role in the selective recruitment of basophils in vivo., Recombinant human IGF-I regulates progenitor cell division in the ventricular zone by reducing G1 phase length and decreasing total cell cycle length but increases cell cycle reentry in mouse embryos., AIB1 is required for IGF-I-induced proliferation, signaling, cell survival, and gene expression in human breast cancer cells, independent of its role in estrogen receptor signaling, The effect of serum withdrawal on the autophagy of dysfunctional mitochondria is prevented by the addition of IGF-1., Val44 is an essential residue involved in the IGF-IGF-1R interaction, and a a naturally occurring mutant human IGF-I is associated with growth and developmental abnormalities, Endogenous gonadal steroid secretion appears to result in increased responsiveness to GH in peripubertal girls and boys., RACK1 has a scaffolding function and regulates adhesion and insulin-like growth factor I signals that are necessary to regulate Akt activity and to promote turnover of focal adhesions and cell migration, Systemic administration of IGF-1 improves structure/function of delta-sarcoglycan deficient cardiac muscle in the hamster., IGF-I has the characteristics to be a marker for the insulin resistance syndrome., Serum IGF-1 levels and IGF-1/Insulin-Like Growth Factor Binding Protein 3 ratios increased with advancing pubertal stages, increased expression of human IGF-IA in alveolar air spaces does not affect the development of pulmonary fibrosis but promotes premalignant changes in the alveolar epithelium., Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis., IGF-1 levels decreased significantly six months after the iodine supplementation., Serum IGF-1 levels differed significantly between pubertal developmental stages., higher serum levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in polycystic ovary syndrome (PCOS) women may be related to the increased vascularity that underlies the increased ovarian blood flow, The induction of the raf-1/MEK1 pathway blocks IGF-1-mediated intracellular neuroendocrine hormone regulation. This pathway may be a therapeutic target in gastrointestinal carcinoid tumor therapy., The expression of IGF-I is significantly altered in renal cell carcinoma, Megative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects, which is modified by obesity., Recombinant human IGF-I promotes proliferation and inhibits osteoblastic differentiation and mineralization of bovine vascular cells via both ERK and PI3K pathways., Results indicate that the degree of prematurity, low enteral protein intake, male gender, and slow weight gain are associated with a slower postnatal increase of IGF-I in preterm infants., IGF-I deficiency is part of the underlying mechanism of diminished islet growth in GHR(-/-) mice and are consistent with the notion that IGF-I mediates growth hormone-induced islet cell growth., Hepatic immunoreactive IGF-I was significantly correlated with serum IGF-I and nitrogen balance., High IGF-1 levels are linked to early-onset breast cancer and larger breast volumes., AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation., Studies in transgenic (OC-IGF-I) mice show that osteoblast-derived IGF-I determines skeletal insulin-like growth factor binding protein 5 (IGFBP-5) abundance, at least in part by inducing its synthesis., Effect pf genetic and environmental factors on levels in female twins in puberty., The IGF1(70 amino acids) is single-chain polypeptides structurally similar to proinsulin., PTEN may inhibit antiapoptotic IGF actions not only by blocking the IGF-IGFR-induced Akt activity, but also by regulating expression of components of the IGF system, in particular, upregulation of IGFBP-3, IGF)-1 and its receptor are present in the human male genital tract, Critically ill children are characterized by low levels of IGF-I and -II as well as IGFBP-3 accompanied by elevated levels of GH, probably reflecting the development of peripheral GH resistance., IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment., response rate of hematocrit to enalapril treatment in patients with post kidney transplant erythrocytosis affects IGF1 levels., IGF-I and HGF cooperate to induce migration and invasion of colorectal carcinoma cells, and c-Met and uPA/uPAR are required for IGF-I-mediated migration and invasion., Rapid increase of serum free IGF-1 level before 12 years might be a predictor of the growth spurt and breast development., Increased IGF-I levels correlated with increased growth, tumor extent, and aggressiveness., higher levels of circulating IGF-I may increase risk of several cancers and relatively higher IGF-I levels may reduce the risk of type 2 diabetes and coronary heart disease., SHPS-1 functions as an anchor protein that recruits both Shc and SHP-2, whose recruitment is necessary for IGF-I-dependent Shc phosphorylation, Pituitary gamma-knife surgery in acromegaly is effective in lowering serum IGF-I to normal levels., Thus these data suggest that the IGF1 promoter polymorphism may influence the strength response to ST. Larger sample sizes should be used in future studies to verify these results., leptin and the IGF system of IGF-I, IGFBP-2, and IGF-I receptor do not interact directly in a cell culture model of neuroepithelioma cells, The action of insulin-like growth factor-1 might be responsible for elevated luteinizing hormone levels and the consequent hyperandrogenic anovulation observed in normal weight women with polycystic ovary syndrome., In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle, C-domain of IGFBP-2 plays a key role in binding regions of IGF-I and -II that are also involved in binding to the type-1 IGF receptor, Increased breast cancer risk in women with promoter polymorphisms in IGF1 and IGFBP3 genes, with increased risk for individuals homozygous for both polymorphisms., Osterix regulation by IGF-I requires all three MAPK components (Erk, p38, and JNK) in human mesenchymal stem cells, IGF-I can significantly stimulate trophoblast cells adhesion to fibronectin., Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients, following UV insult the IGF system, including IGF-1 may enhance keratinocyte viability and contribute to a return to epidermal homeostasis, Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP-1, IGF-I and related metabolic variables such as glucose tolerance., insulin-like growth factor-I increased invasion activity in ARK5-mRNA expressing multiple myeloma cell lines, IGF-I is degraded at its C-terminal D-domain within the endosomal apparatus by cathepsin B., Folic acid deficiency could result in reduction of IGF-1 protein levels and might contribute to formation of defects in the skull bone as observed in mengingocele patients, PAPP-A increased the proliferation and differentiation of myoblasts, its myogenic effect is governed by its proteolytic activity, and it promotes skeletal myogenesis by increasing the amount of free IGFs., These studies show IGF-I phosphorylation of FKHR and FKHRL1 via a PI3-K-dependent pathway in neuroblastoma cells., IGF-I may act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneration in concert with stromal cell derived factor., Age-stratification should be undertaken in larger investigations of IGF-I levels as predictors of postmenopausal breast cancer, Clustering of family history of diabetes, testosterone and IGF I abnormalities, and high high-sensitive C-reactive protein is associated with metabolic syndrome in Chinese middle-aged men., The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I-induced IGF-I receptor activation and function in human intestinal muscle cells., observations demonstrate that leptin directly controls the secretory activity of human ovarian cells and confirm the involvement of insulin-like growth factor (IGF)-I in the regulation of ovarian cells, IGF-I actions likely depend on cell type, developmental stage, and microenvironmental milieu {REVIEW}, Review of recent studies shows that IGF-I signals cross-talk at multiple levels with various components of transforming growth factor (TGF)-beta signaling pathway which, depending on context, may function either as tumor suppressor or as tumor promoter., IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer., Regions upstream and downstream of the CWCV motif in IGFBP2 participate in IGF-1 binding., Lower serum IGF-I concentration together with higher bone resorption and low bone mineral density reveal involvement of this growth factor in the development of idiopathic decrease of bone mass in children., Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults., Leptin and the molar excess of leptin receptor are better biomarkers of nutritional status than IGF-I in protein malnutrition children during nutritional recovery., results show a local increase in the expressions of IGF-1 and PDEGF in the muscularis propria of the pyloric muscle in children with IHPS, which may have implications to the pathogenesis of the disease., IGF-I and IGFBP-3 levels were positively associated with weight gain and height gain from birth to 3 months in small for gestational weight versus appropriate weight children., the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer, The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression., Igf-I transduction up-regulated markers of osteoblastic differentiation and in conjunction with recombinant BMP-2-induced matrix mineralization independently of Dex., These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms., We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction, variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an abnormal glucose tolerance, results support the contention that the associations between height and cancer may be mediated by variation in childhood insulin-like growth factor 1, IGF-I and -II are chemotactic factors for mesenchymal progenitor cells; IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells, Effect of human IGF-I over-expression on mice skeletal muscles was studied., first study to document an association between timing of puberty and adult insulin-like growth factor 1(IGF-I) levels, The mechanisms by which IGF-I may influence bone metabolism are not fully understood, but as the reviewer points out, they are a predictor of bone mass density and are positively associated with vitamin D concentrations., progenitor cells are potent sources of VEGF, HGF, and IGF-I, IGFBP-1, IGFBP-3 and IGF-I show acute changes following a glucose load and there are marked gender differences in these responses., IGF-I and its downstream pathway is a valuable therapeutic approach to overcome Ara-C resistance in AML., higher concentrations of neuropeptide Y in constitutional delay of puberty(CDP) girls may be responsible for CDP and reduced levels of insulin growth factor-I(IGF-I), overexpression of rtEa4 or hEb transgene in zebrafish embryos disrupts heart development, hematopoiesis, and vasculogenesis by reducing the levels of GATA 5, NKX2.5, GATA 1, GATA 2, and VEGF mRNA, VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia, Upon IGF-I stimulation, a complex assembles on SHPS-1 that contains SHP-2, c-Src, and Shc wherein Src phosphorylates Shc, a signaling step that is necessary for an optimal mitogenic response, Data show that hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant., The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise., IGF-I can augment IL-8 expression through activation of AP-1., concurrent administration of tamoxifen and bicalutamide in prostate cancer patients reduces the synthesis and bioavailability of IGF-1, reduction in bioactive IGF-I may be related to the higher levels of free IGFBP-1 and the faster disappearance of IGFBP-1-bound IGF-I in glucose tolerance test in liver cirrhosis, findings suggest that this insulin-like growth factor 1(IGF-I) gene polymorphism is associated with an increased risk of diabetic retinopathy, A decrease in free IGF-I and insulin-like growth factor binding protein 3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications, IGFs co-activate proliferative and apoptotic pathways in LIM 1215 cells, which may contribute to increased cell turnover., The structures reveal the mechanisms of insulin-like growth factor (IGF) signaling regulation via insulin-like growth factor-binding proteins (IGFBP) binding., heterotrimeric G protein-dependent ERK1/2 activation is mediated by IGF-1 and IGF-2 by transactivating sphingosine 1-phosphate receptors, High plasma levels of IGF-1, IGF-2, and IGFBP-3 were associated with good prognosis in patients with advanced NSCLC., IGF-1 cell signaling leading to collagen synthesis in fetal lung fibroblasts is mediated by PI3 Kinase acting through NF-(k)B in HFLF., IGF-1 is more potent in inducing the survival of vascular smooth muscle cells from asymptomatic patients as compared to that of symptomatic subjects., Forced RIZ1 expression in CML-BC cell lines decreases IGF-1 receptor activation, Low levels of IGF-I may be a useful predictor of abnormal glucose metabolism in patients with acute myocardial infarction., Differential expression of insulin receptor, IGF-IR, and IGF-I in adhesion fibroblasts may contribute to pathogenesis of fibrosis in diabetic patients., This study demonstrates a direct interaction of the IGF and TGF-beta systems in human renal carcinoma cells. The observations that IGF-I enhances the TGF-beta signaling and that TGF-beta promotes IGFBP-3 production., transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2), Precise orientation of IGF-I within the IGF-I-IGF-1R complex involving the IGF-I C-domain binding to the IGF-1R CR domain., Stromal cell IGF-1 mRNA levels are significantly decreased after castration in non-malignant, but not malignant prostate tissue., insulin-like growth factor-1 alters Mdm2-mediated GRK2 degradation, leading to enhanced GRK2 stability and increased kinase levels, High insulin-like growth factor-1 levels are associated with early-onset breast cancer, results may indicate that up-regulation of the cardiac IGF-1 system serves as a compensatory mechanism for LV dysfunction, Platelet factors promote fibroblast growth by activating preotein kinaes, which requires production of IGF-1., This review of available data suggests an algorithm of circulating levels of IGF-I, together with evaluation of auxological data, to assess the likelihood of growth hormone deficiency in pre-pubertal children., Seems to be an important positive regulator of cartilage oligomeric matrix protein., lack of association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb, These results demonstrate that estradiol positively regulates essential proteins of the IGF signalling pathway., Genetic variation in IGF1 is associated with breast cancer risk, polymorphisms in the IGF-1R and IGFBP3 genes, but not IGF-1 or IGFALS, may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status, the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis, GH1/IGF-1 axis polymorphisms may have a role in breast cancer development [review], the differences in the IGF-I response to GH between tall obese and short children may reflect differences in the respective anabolic (growth promotion) and metabolic (i.e. insulin action modulation); roles of circulating IGF-I is unknown, Results indicate that common variation in the IGF1 gene, particularly in the 3' region, may affect prostate cancer risk., upregulation of the muscle specific IGF-IEa and MGF isoforms occurs within 2.5h of a single bout of isometric exercise in women, circulating levels may be lowered in patients with head and neck cancer, Cerebrospinal fluid levels are lower in motor neuron disease than in normal controls., plasma levels of IGF1 and IGFBP-3 vary by ethnic group and have roles in development of obesity, Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression., inhibition of IGF-1 signaling combined with interferon-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own, Those results reinforce the possibility that the IGF-1Ec isoform may produce an E domain peptide that can act as a cytokine., Results suggest a major role of IGF1 system in promoting cholangiocyte survival., IGF-1 increases nuclear translocation of liganded estrogen receptor (ER)-alpha in breast cancer cells., Individuals with IGF-I189 are more likely to have low leg lean mass and to perform better in activities requiring exercise economy and endurance performance., study elucidates a mechanism by which insulin and IGF-1 signaling can be matched to the oxygen level that is available to support growth and energy metabolism., exposure to hypoxia and acidosis at birth strongly correlated with a fall in IGF-1 and IGFBP-3 levels in cord blood, the increase in LVM prevalent in human essential hypertension is directly associated with serum GH levels and inversely related to circulating IGF-1, IGF-1 stimulated EPC differentiation, migration & incorporation into vascular networks in vitro via its receptor, increased telomerase activity & endothelial nitric oxide synthase expression, phosphorylation & activity in a PI-3-kinase/Akt-dependent way., The leptin and IGF-1 may contribute to the pathogenesis of polycystic ovarian syndrome., 1,25-dihydroxyvitamin D and/or IGF-I may be involved in the regulation of urinary calcium excretion, alterations in glucose concentrations may regulate the ability of smooth muscle cells to respond to IGF-I, Circulating levels of total IGF-I were not associated with risk of total coronary events or ischemic stroke among older adults., Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c., Review provides novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation and its clinical applicability in preventing dysfunction and sodium pump activity in type 1 diabetes., Common genetic variation in IGF1 is strongly associated with percentage mammographic density, IGF-1 induces phosphorylation and an increase of the AP1 complex, which is phosphorylated and binds to the pS2/TFF1 promoter, allowing recruitment of the chromatin remodeling factor Brg1 followed by binding of ERalpha via its interaction with c-Jun, inhibition of signal transduction pathways common to growth factors such as igf1 appears as a challenge to glioblastoma multiforme inhibition studies. [TRVIEW], Bioavailability of IGF-I appears to play a key role in oocyte maturation in patients with polycystic ovary syndrome., Mice, transgenic with IGF1, express multiple anti-apoptotic protein in epidermis., In human keratinocytes, insulin-like growth factor-1 (IGF-1) induces the expression of LL-37., Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF1 hypothesis of osteochondrodysplasias., Presence of two Androgen Receptor response elements within the IGF-I upstream promoter that act in cis to activate IGF-I. expression., Our results suggested a potential effect of SNP3 in the IGF1 gene on age at menarche variation in Caucasian women for the first time., data confirmed hypothesis that higher growth velocity in the first month of preterm neonates is due to an increased bioavailability of IGF-I, first study showing the role of the promoter region of the IGF-I gene polymorphism and the level of plasma IGF-I and body composition parameters in Japanese infants; results suggest genetical influence on prenatal growth and serum IGF-I levels, IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system, These data point to an interesting relationship between low IGF-1 levels and increased cardiovascular risk factors among chronic kidney disease patients as compared to age-matched healthy control subjects., IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms, Autosomal dominant polycystic kidney disease cells had an increased sensitivity to IGF1 and to cyclic AMP, which required PI3-kinase and the mitogen-activated protein kinase, extracellular signal-regulated protein kinase (ERK) for enhanced growth, We demonstrated that children with sickle cell anemia have abnormalities in the IGF-I axis, which worsen with age., IGF-I synthesis is disturbed in chronic hepatitis C and reflects the severity of the liver fibrosis; may be a biological marker, IGF-I system is important in the assessment of adaptation to stress imposed by high levels of physical activity and energy/sleep restriction and is more closely associated with losses in body mass and fat-free mass than other nutritional biomarkers., IGF-related peptides are most likely synthesized locally and might be involved in the initiation and/or progression of neointimal thickening of primary arteriovenous fistulas., The IGF-I/IGF-I-receptor pathway plays an essential role in the development and maintenance of the malignant phenotype by favoring cell survival & inhibiting apoptosis. Review., IGF-I-immunoreactivity was confined to secretory granules in coexistence with ACTH- or GH-immunoreactivity, respectively, indicating a concomitant release of the hormones., Serum testosterone concentration and serum IGF-1/IGFBP-3 molar ratio are the major determinants of bone mineral density in boys at different pubertal stages., IGF-I interacts with estradiol to promote the proliferation of breast carcinoma cells via reactive oxygen species-dependent MAPK activation and c-Jun protein expression., IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus site, IGF1-19/-19 genotype was significantly more common among BRCA1 mutation carriers (14.2%) than among non-carriers (4.8%), Nordihydroguaiaretic acid inhibits IGF1 signaing, growth, and survival in neuroblastoma cells., review of changes during aging which contribute to the decline in GH/IGF-I, including changes in signal to the somatotrophs from growth hormone releasing hormone, somatostatin and other factors such as body composition, exercise, diet and sleep, Results indicate that positive correlations of maternal, fetal, and neonatal IGF-I levels with customized centiles underline implication of its role in fetal growth., the IGF-1 axis is downregulated by curcumin in MCF-7 cells, which inhibits cell growth and induces apoptosis, we discuss the IGF system with emphasis on the cardiac actions of IGF-I under normal and pathological conditions --{REVIEW}, IGF-1 expression is activated by hypoxia through STAT5b in human HepG2 cells, IGF-1 regulates ether-a-go-go channel activity in breast neoplasms, via an Akt pathway to promote cell proliferation., seminal vesicle fluid is a local source of IGF-I that provides chronic stimulation of prostate cells, Upregulates Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein (FLIP) expression in thyroid cells by means of the phosphatidylinositol 3-kinase-dependent pathway that finally leads to activation of NF-kappaB., Severely deficient in a case of insulin-resistance syndrome (Rabson-Mendenhall type)., The results of this study suggest a positive correlation between the increased levels of IGF-1 and colon cancer and are thus consistent with the hypothesis that the level of IGF-1 plays an important role in the development of colon cancer., the two systems, TRs and IGF1/IGF1R could be functionally associated., The IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer risk in Caucasian postmenopausal women., Common genetic variation in IGF1, IGF binding protein 1 (IGFBP1), and IGFBP3 influences circulating levels of IGF-I, IGFBP-1, and IGFBP-3., Plasma levels of IGF-I were significantly increased in volunteers with alopecia after oral administration of capsaicin and isoflavone ., Dichlorodiphenylchloroethylene alters the expression of the ovarian growth factors VEGF and IGF-1 in vitro., novel role for autocrine IGF-I signaling in the growth and survival of primary acute myeloid leukemia cells, large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGF-1, These results raise questions concerning the therapeutic value of IGF-1 and indicate that further studies are needed to examine the relationship between methods of IGF-1 administration and its potential therapeutic value., AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases., Data show that an antenatal course of glucocorticoids elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations., Connexin43 expression can be influenced by Ang II and IGF-1 through ERK and p38 pathways and may contribute to the pathogenesis of vein graft disease following coronary artery bypass grafting., Strong association of high IGF-I expression levels with good prognosis was observed especially in lymph-node negative patients., hyperglycemic conditions enhance the response of retinal endothelial cells to IGF-I by increasing the association of IAP with SHPS-1 permitting the formation of the SHPS-1-Shc signaling complex, which is required for the proliferative response to IGF-I, MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II., Maternal diabetes is associated with significant alterations in IGF-1 blood levels in male newborns., IGF-I levels were lower in patients with ectopic neurohypophysis than in those without structural abnormalities of the hypothalamic pituitary axis (n = 25), but patients without structural abnormalities also had significantly lower serum IGF-I levels, high serum IGF-I levels are associated with goiter, No significant differences in grade or ethnicity was found in IGF1 repeats and the inverse association with prostate cancer risk, No significant differences in levels in fibromyalgia patients., Exercise-associated mechanisms, such as increased energy flux, regulate IGF-I independently of energy deficit., Growth hormone deficiency alone does not account for the high prevalence of reduced IGF-1 in adult beta-thalassemia., Low levels of IGF-1 found in obesity may be related to obstructive sleep apnea syndrome., Serum levels are indicative of prostate carcinogenesis., IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women., Recombinant human insulin-like growth factor I therapy could improve glucose disposal by signalling through the IGF-I receptor, whilst reducing the adverse effects of high insulin concentrations., The data indicate that serum free IGF-I and IGFBP-1 are implicated in early atherosclerosis., IGF-1 plays a role in potentiating platelet aggregation by complementing G(i)- but not G(q)-signaling pathways via PI3-K p110alpha., IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses, 18-repeat genotype is a susceptibility genotype for diabetic retinopathy and its clinical severity in a Southern Indian cohort., In a group of older US men, the suggestion of a positive association between IGF-1 and lower urinary tract symptoms was observed., Variants of the IGF1 promoter region are not associated with birthweight., polymorphisms identified in the upstream core polyadenylation signal at IGF1 exon 6 do not cause IGF1 deficiency, Data show that adipose tissue-derived stem cells (ASCs) secrete significant amounts of VEGF (810.65+/-56.92 pg/microg DNA) and IGF-I (328.33+/-22.7 pg/microg DNA)., variation in the IGF-I gene plays a role in prostate cancer susceptibility by influencing circulating levels of IGF-I (Meta-Analysis), Osteopenia is common in children with cerebral palsy and may be associated with lower IGF-1 and IGFBP-3 levels, IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet., IGF-1 plays a role in maintaining muscle GLUT3 expression and basal glucose uptake via the transcriptional factor Sp1., PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion, An impairment of the GH/IGF-I axis might be involved in the biochemical mechanisms determining delayed or failed fracture healing, The circulating serum insulin-like growth factor-1 does not have a significant influence on bone mass in elderly type 2 diabetes mellitus patients., Growth hormone may influence luteal function directly or indirectly via IGF-1., IGF-I levels determine aortic intima-media thickness in neonates with intrauterine growth retardation and in healthy controls., Blocking Hsp90 disrupts IGF-I and IL-6-induced proangiogenic signaling cascades by targeting IGF-IR and STAT3 in pancreatic cancer, IGF-1 transmits its lipogenic signal in sebocytes through activation of Akt, Use of a strategy consisting of IGF-1 determination in blood is predictive of growth hormone deficiency., study established age- and sex-specific reference ranges for serum IGF-1 and IGFBP-3 levels, Blood levels are not significantly associated with metabolic syndrome among those with the lowest levels of 25-hydroxyvitamin D in a British cohort., IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis., Endometrial IGF-I and -II are differentially regulated during decidualization and by human chorionic gonadotropin., Expression of IGF-1(des) in mouse prostate epithelium is sufficient to cause hyperplastic lesions in all mice, however the well-differentiated lesions did not progress to adenocarcinoma within a year., no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk., An inverse significant relationship between IGF-I and both brain natriuretic peptide (BNP) and amino-terminal propeptide of procollagen type III (P-III-P) value in surgically treated acromegaly patients was observed., Silent-RNA-mediated downregulation of BRCA1 in primary human breast cancer gland tumor cells triggers upregulation of endogenous intracellular IGF-I in vitro., In osteoarthritic cartilage, catabolism was insensitive to IGF-I, but IGF-I exerted a robust stimulation of anabolism at sufficiently high doses., Hyperlipidemia is associated with altered levels of insulin-like growth factor-I., This finding raises concerns, given the association between increased IGF-1 and elevated colon cancer risk, and adds to the literature suggesting a potential benefit from ovarian preservation., single nucleotide polymorphisms in IGF-I gene is significantly associated with elevated levels of IGF-I and higher percent breast density., MGF splice variant is sensitive to muscle damage-inducing exercise and is differentially regulated compared with IGF-IEa., The IGF-I signaling abnormalities in osteoporotic osteoblasts were associated with reduced DNA synthesis both under basal conditions and after stimulation with IGF-I., study provides the first mechanistic insights into the action of IGF-I-IGFBP-VN complexes and adds further evidence to support the involvement of VN-binding integrins and their cooperativity with the IGF-IR in the promotion of tumor cell migration, IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin, Leptin at the low doses enhanced, whereas at the high dose it suppressed the effect of GH or IGF-I on steroids synthesis in cultured lutein granulosa cells., Evidence for association between IGF-i single-nucleotide polymorphisms has been found., Data concluded that the higher risk of preterm preeclampsia related to IGF-I increase may reflect placental disease., Stimulation of KLF6 expression by IGF-I in a p53-dependent manner may constitute a novel mechanism of action of IGF-I, with implications in normal cell cycle progression and cancer biology., These findings suggest that serum levels of IGFBP-3 and possibly IGF-I are associated with the rate of HIV disease progression in women., A concurrence of elevated GH levels and decreased IGF-I, IGFBP-3, and total ghrelin levels during the early burn injury period., Repeat polymorphism of IGF1 is unlikely to be a major determinant of susceptibility to cancer on a wide population basis., Study found significantly lower insulin-like growth factor-1 concentrations in premenstrual dysphoric disorder subjects compared with controls., Genetic variants in the IGF-I genes is not associated with breast cancer, The basis for interactions between tumor necrosis factor and insulin-like growth factor-1 is discussed in this Review with specific reference to clinical consequences for myofiber necrosis of skeletal muscle., IGF-1 plasma concentrations do not correlate with alcohol craving in a longitudinal study of 12-weeks abstinent alcoholics., IGF-I is involved in ovarian cancer progression; both endocrine and paracrine/autocrine are involved in the regulation of IGF-I activity in ovarian cancer., association observed for IGF-I(CA)(19) and malignant melanoma is in keeping with similar results obtained in prostate or breast cancers, suggesting that this type of repeat may be important in controlling cancer induction and its severity, IGF-1 signaling is an important event in blast crisis transformation in chroni myelogenous leukemia., Three of the nine SNPs within evolutionarily conserved regions(rs35455143, rs35765817 and rs3839984) were significantly associated with circulating IGF1 levels., Higher early levels of the human milk IGF system might contribute to maturation of the infant gut., Signal transduction of IGF1 and cell division may be prevented by lycopene in prostate tumor cells., IGF-I up-regulates mu-opioid receptor OPRM1 transcription in PC12 cells lacking REST, in SH-SY5Y cells transfected with constructs deficient in the REST DNA binding element, or when REST was down-regulated in retinoic acid-differentiated cells., In hyperthyroidism, Measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis., There is a novel function of ADAM-12m in chondrocyte proliferation and cloning in osteoarthritic cartilage through enhanced bioavailability of IGF-1 from the IGF-1-IGFBP-5 complex by selective IGFBP-5 digestion., analysis of insulin-like growth factor I receptor and HER2 in breast cancer, Sequence analysis of the IGF1 and IGF1R genes of female centenarians showed overrepresentation of heterozygous mutations in the IGF1R gene among centenarians that are associated with high serum IGFI levels and reduced activity of the IGFIR, Genetic variation in IGF1 alters IGF-1 concentrations but is not associated with growth, glucose metabolism or type 1 diabetes., data suggest that low concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) could be a reliable marker to differentiate benign from malignant ovarian tumors, No association between IGF polymorphisms and TGCT risk., glucose, cannabinoids and insulin-like growth factor-1 have roles in protecting cells from paraquat-induced apoptosis, IGF1 helps predict disease outcome in GIST patients., Authors observed evidence for association of GHRL polymorphisms with circulating IGF-I levels and with breast cancer risk., PAPP-A and IGF-1 are elevated in patients with acute coronary syndrome, first study displaying cardiac expression of insulin-like growth factor-I mRNA and growth hormone receptor mRNA in children with congenital heart disease, data indicate that strong cooperative cross talk between prolactin and IGF-I augments biological processes associated with neoplastic progression, with implications for therapeutic strategies, This study is the first to demonstrate that the systemic levels of IGF axis components are associated with the presence and severity of PAD, & that the inflammatory status of the ischaemic limb affects the transfemoral concentrations of IGF-1 & IGFBP-3., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration, there was decreased insulin-like growth factor 1 (IGF-I) immunoreactivy in extravillous trophoblasts and increased IGF-I immunoreactivity in cytotrophoblasts and decidual cells of small for gestational age cases, Plasma levels of Th1/Th2 type cytokine are associated with change of prolactin and GH/IGF-I in hemodialysis patients., IGF-I protects against endoplasmic reticulum (ER) stress-induced apoptosis by increasing adaptive mechanisms through enhancement of ER stress-signalling pathways, thereby restoring ER homeostasis and preventing apoptosis, A low concentration of serum IGF-1 on admission was associated with a poor early prognosis of acute myocardial infarction, IGF- I exerts a mitochondrial protection in experimental cirrhosis leading to reduced apoptosis and increased ATP production., Examine relationship between GH/IGF-1/leptin levels and sleep duration in obesity., this study shows an association between an IGF-1 promoter region polymorphism and absolute counts of lymphocytes subsets in neonates., IGF-I, IGF-II and IGFBP-3 mRNA expression and tissue levels of IGF peptides are regulated by different mechanisms, Relationship between in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density, activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11, Former sedentary postmenopausal women submitted to resistance training gained muscle mass and muscle strength significantly associated with insulin-like growth factor 1(IGF-1) increase, IGF-I, in addition to the C-domain, uses surfaces similar to those of insulin in contacting its cognate receptor, These data demonstrate that IGF-I modulates proliferation and strongly stimulates migration of glioma cell lines in vitro., IGF-I regulates immature testicular cell proliferation, apoptosis and steroidogenesis., This study suggests that there is an interaction between leptin, IGF-1, IGFBP-3 and insulin resistance in patients with chronic kidney disease., A logistic regression analysis, adjusted for age and sex, has been used to determine the association between tertiles of IGF-1 and IL-6 and metabolic syndrome X., an emerging clinical target for improving the clinical manifestations of Alzheimer's disease may be the activation of Growth hormone and insulin-like growth factor-I, Common IGF1 and IGF1R gene polymorphisms, such as single nucleotide polymorphisms and variable number of tandem repeats, have been investigated with conflicting results with respect to small for gestational age-related outcomes.[review], The variant type of the IGF-I promoter region is associated with lower blood pressure but not with left heart dimensions at the age of 2 years., Ghrelin is higher in old men in comparison to women and decreases over time with a steeper decline in subjects with metabolic syndrome; moreover, in these subjects ghrelin/IGF-I correlation is lost., Production of PAPP-A by disc cells is important since PAPP-A cleaves IGF-binding proteins, and makes IGF-I, a potent mitogen and antiapoptotic agent, available to cells., the important effects of IGF1 and ESR2 on adult height variation in Caucasians, and first suggested the potential sex-specific effect of ESR2 on height variation in Caucasian women., increased expression 6 months after orthognathic surgery indicates an adequate [masseter]muscle adaptation, Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation, the Gab1-SHP2-ERK1/2 signaling pathway comprises an inhibitory axis for IGF-I-dependent myogenic differentiation., the association between common genetic variation in the IGF1 genes in relation to circulating IGF-I levels and breast cancer risk, These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration., IGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases, None of the components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN influence the relation between IRS-1 genotype and prostate cancer risk. Ther is no association between carriage of the variant IRS-1 gene and prostate cancer risk., Competitive equilibrium binding assays revealed significantly reduced specific binding to the insulin, IGF-I, and IGF-II and their receptors in both the anterior cingulate and vermis of alcoholic human brains., A high IGFI, Insulin-like growth factor-I CA repeat is an important modifier of disease onset in hereditary non-polyposis colorectal cancer., Independent predictors of Growth hormone deficiency (GHD) were, Lower insulin-like growth factor 1 is associated with colorectal cancer., IGF1 is a common target gene of Ewing's sarcoma fusion proteins EWS-FLI-1, EWS-ERG and FUS-ERG in mesenchymal progenitor cells, the relatively high IGF1 secretions in elderly patients might be involved in the progression of clinical complications in acromegalic patients, These results indicate the critical point thymic function regulation by IGF-1 involves thymic epithelial cells expansion regulating thymocyte precursor entry and facilitating thymocyte development., the IGF-I axis can be programmed early in life., patients with poor diabetes control have lower levels of IGF-1, and greater IGFBP-1, IGFBP-5, and bone-specific alkaline phosphatase, A large proportion of rheumatoid arthritis inpatients, mainly women, had rheumatoid cachexia. The muscle wasting was explained by inflammatory activity and physical disability as well as low bioavailable IGF-1., Mean blood spot IGF-I levels were significantly higher in the late pubertal stages than in the prepubertal, early pubertal, and postpubertal stages, phosphatases and pRB have important roles in IGF-I/mTOR-mediated cell survival, Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction, Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis, klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer, Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1alpha, High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk, Our results suggest an association between the number of 185 alleles at 3' ends of IGF1 with percentage mammographic density, Non-hispanic blacks have the highest molar ratio of IGF-I, dysregulated IGF and steroid hormone receptor signaling is prominent in endometrial benign stages and these alterations could represent clinical indicators for the risk of EnCa (endometrial carcinoma) and also help in development of new therapies., The enhanced SULT1E1 activity may have a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of E2., Estradiol(2)-induced proliferation of endometrial carcinoma cells is mediated by the MAPK3/1 pathway via autocrine stimulation of IGF1., IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children., IGF-1 transgene expression induces massive stem cell mobilization via SDF-1alpha signaling and culminates in extensive angiomyogenesis in the infarcted heart., No correspondingly different adaptations in basal blood concentrations of neurotrophins IGF-1 and BDNF after endurance training., IGF1 increased in decidual cells in preeclampsia., we demonstrated that IL-21 induced clonogenicity through an autocrine IGF-1 secretion in human myeloma cell lines and primary myeloma cells, Review focuses on the critical aspect of the insulin/insulin-like growth factor I (IGF-I) network involved in crosstalk with estrogen receptor alpha and implicated in breast cancer development and progression., IGF-1 (insulin-like growth factor 1) levels were higher in patients with diffuse cutaneous SYstemic sclerosis (SSc) than in patients with limited cutaneous SSc; Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis., IGF-I is a more important metabolic regulator in skeletal muscle than previously estimated., ER alpha mRNA is positively correlated with IGF-I mRNA, which implies that estrogen upregulates the gene encoding IGF-I through ER alpha in leiomyoma., IGF1 rescues human intervertebral annulus cells from in vitro-stress-induced premature senescence., no association found between IGF-1 and Crohn's disease recurrence, Data demonstrate that serum deprivation induces epigenetic changes in MSCs to upregulate the expression of the proangiogenic and antiapoptotic factors IGF1 and leptin., Insulin-like growth factor-1-induced activation of the phosphatidylinositol 3-kinase/c-Akt/NF-kappa B signaling pathway is involved in the modulation of endogenous decoy receptor 3 expression in AsPC-1 pancreatic adenocarcinoma cells., The IGF1 gene alone or in concert with diabetes increases the risk of pancreatic cancer., Circulating IGF-I appears to be growth hormone (GH)-independent in GH deficiency (GHD) patients with a low IGF-I, but remains partially GH-dependent in GHD patients with a normal IGF-I., Low intrauterine IGF-I serum levels may account for thinner and stiffer umbilical arteries in IUGR infants., possible that inhibition in the mammary gland may eventually play a role in breast cancer chemoprevention, In female athletes nutritional composition has an impact on serum hormones (leptin, IGF-1 as well as estradiol) and may be also on cytokines (IL-6)., promotes cord blood T cell maturation by means of accessory cells (monocytes) and in part by IL-6, We here report detection of a functional enhancer module in the upstream IGF1 promoter region, which might play a key role in local IGF1 bioavailability., IGF-1 related gene variations influence susceptibility to multiple myeloma., Effects of different CMV-heat-inactivation-methods on IGF-1 in human breast milk., Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins., results argue for the importance of polymorphisms in the IGF1 signalling pathway in combination with myostatin on the variant degree of physiological hypertrophy of male athletes., Serum IGF-I protein in healthy black and white young men, interaction between IGF-I and ghrelin modifies the association of ghrelin with early atherosclerosis, These results suggest that IGF-1 promotes Abeta production through a secretase-independent mechanism involving APP phosphorylation., A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants., For IGF-1, IGFBP-3 and SHBG, no differences were found between surgically and naturally postmenopausal women, Genetic variations of the IGF-1 gene is not a major influencing factor in causing variable responses to somatropin treatment in growth hormone deficient adults., Serum levels of IGF-1, IGF-2, ALS, and IGFBP-3 were reduced in children with congenital disorders of glycosylation., High IGFBP3 concentrations in amniotic fluid at the beginning of the second trimester are associated with increased risks of small for gestational age (SGA) while 19CA/20CA genotype at IGF-I VNTR polymorphism is associated with reduced risks of SGA., The present study found inverse associations between insulin-like growth factor 1 or IGF binding protein 3 levels and mortality from all causes, High IGF-1 is associated with multiple myeloma., Our results do not strongly support an association between these IGF1 CA repeat variants and breast cancer risk., a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas, expression in hair follicules is elevated following treatment with glycogen synthase kinase-3 inhibitor, (2'Z,3'E)-6-bromoindirubin-3'-oxime, Common IGF-I SNPs show less influence on plasma IGF-I levels among African Americans and Caucasians., Angiotensin II can time- and dose-dependently induce PAPP-A and IGF-1 mRNA expression in human umbilical artery smooth muscle cells., IGF-1 secreted by testicular Leydig cells plays an important role in maintaining the pluripotency of spermatogonial stem cells in culture, These data demonstrate that IGF-IR/integrin beta1 cross talk is followed by integrin beta1 lipid raft compartmentalization and that Cav-1 is required for this process., The potentiation of androgen signaling through androgen receptor activation and the subsequent effects on antineoplastic responsiveness of prostate carcinoma is reported., It appears that the postoperative growth spurt in infants with cyanotic congenital heart disease (CHD) is mediated through activation of the GH/IGF-I system and improved nutrition., Low levels of IGF-1 are associated with delirium., Our findings suggest that IGF-I may regulate neuronal PDK-1 differently than in non-neuronal cells, which may indicate a novel role for PDK-1 in IGF-I-mediated neuroprotective signaling., role of insulin-like growth factor-1 in skeletal muscle growth and homeostasis have excited new interest in this important mediator of anabolic pathways and suggest promising new avenues for intervention in catabolic disease, there is broad phenotypic variation within growth hormone (GH) and IGF-I resistant disorders, Results show low nitric oxide and mildly elevated IGF-1 levels in the patients with Parkinson's disease., Serum PAPP-A and IGF1 do not appear to be useful serum biomarkers for carotid atherosclerosis in type 2 diabetic patients with stable glycemic control, despite scientific evidence of their local role in atherosclerosis., Bone histomorphometry parameters were associated with low body weight, low estradiol levels, and increased levels of IGFBP-1, supporting the notion that estrogens and IGFs play regulatory roles in male bone turnover., Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN., immunoreactivity of IGF-I and GSK3a/b signaling pathways studied in ALS spinal cords and hippocampus with special reference to Kii and Guam ALS patients, A significant relationship is demonstrated between IGF1 and glomerular filtration rate in a large sample of never treated hypertensive patients, probably as consequence of insulin resistance/hyperinsulinism., Higher IGF-1 mRNA levels are shown in end-stage dilated cardiomyopathy., involvement of IGF-1 in the ability of acute leukemic bone marrow stromal cells to form capillary-like structures, Data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and insulin secretion., The data from this study indicate that IGF-1 is a constant component of human CSF. It is also concluded that high levels of CSF IGF-1 may be partly related to AD pathophysiology., CJC-1295 activates the GH/IGF-1 axis and causes serum protein profile changes in normal adult subjects, IGF-I levels are not reduced in patients with chronic heart failure and do not influence cardiac status at baseline or the prognosis, dysfunctions of brain insulin and IGF-1 receptors contribute to Abeta aggregation and subsequent synaptic loss, The prevalence of primary IGF1 deficiency was 20% in children with isolated short stature;IGF1 deficiency in some children may be secondary to nutritional deficiency or to maturational delay, IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai, Study shows that association of FAK with RACK1 is required for both FAK phosphorylation and dephosphorylation in response to IGF-I., Conclude the hIGF-1 gene can be transfected into the human meniscal cell efficiently by liposome and it causes accelerated proliferation and differentiation., In conclusion, these results indicate that HA interferes with the delivery of IGF-1 to chondrocytes, affecting the endogenous expression of IGF-1 signaling molecules and the resulting chondrocyte phenotype., IGF-1 levels and the value of IGF-1/IGFBP-3 are significantly increased in colorectal cancer patients., Diet, body composition, and physical fitness affect levels of IGF-I bioactivity in women, IGF-1 might be associated with bilirubin-induced brain damage., activation of insulin-like growth factor 1 pathway can rescue alpha-synuclein toxicity and suppress alpha-synuclein aggregation through the activation of PI3K/Akt pathways., normal IGF-I bioactivity in obese women despite severely reduced endogenous GH secretion., Variations of the stress distribution in cancellous bone correlate with the variation of the concentrations of TGF-beta2 and IGF-I in bone matrix., In formula milk-fed infants, higher IGF-I concentrations may lead to faster gains in length., PI3 kinase is an initial component of the signal transduction pathway which precedes MAP kinase, and MPF activation during IGF-I- and b-insulin-induced oocyte maturation in Cyprinus carpio., Hassall's corpuscles are involved in the local regulation of T-cell development and thymus plasticity during aging by IGF-I/IGF-IR-mediated cell signaling pathway., Circulating levels of IGF1, IGFBP3 and IGFBP3 A-202C play a crucial role in carcinogenesis and could serve as susceptibility biomarkers for cancer development., Impaired IGF-1 system is implicated in the complex mechanism responsible for reduced exercise tolerance in intermittent claudication., Results suggest full-thickness meniscal defects in regions without blood supply can be reconstructed with hIGF-1-enhanced injectable tissue engineering., IGF-1 released from corneal epithelial cells up-regulates the expression of N-cadherin in corneal fibroblasts., Cerebrolysin increased serum IGF-1 in Alzheimer's disease patients., This study demenostrated that the IGF1 is reduced in skeletal muscle of chronic spinal cord-injured patients, The IGF-1 gene seems to be associated with breast cancer risk in premenopausal Ashkenazi Jewish women who are not carriers of mutations in BRCA1/2 genes., The IGF-1/PI3K/PTEN/Akt/NF-small ka, CyrillicB cascade may be a key pathway stimulating metastasis of pancreatic cancer cells., Despite raising levels of exogenous recombinant human IGF-1 in the spinal cord, intramuscular- or intrathecal administration of IGF-1, tissue-specific mRNA expression of MGF isoform produces mature IGF-1 and MGF E peptides which possibly act as distinct mitogens in skeletal muscle regeneration, Menopause causes reduction of IGF-I/IGFBP-3 molar ratio. Women have the trend of progressive hypoactivity of GH to stimulate IGF-I and IGFBP-3 secretions with age., -G1245A SNP appeared to be a marker for well-known -841(CA)(n)/192 bp polymorphism. Haplotype 2, of which the -1245 A allele was marker, was associated with smaller head circumference SDS during spontaneous postnatal growth, but not during GH treatment., the pathology of ALS does not include a deficit in baseline levels of MGF and IGF-IEa mRNA splice variants in muscle, the direct binding to IGF-1 to integrin alphavbeta3 plays a role in IGF-1 signaling through ternary complex formation (alphavbeta3-IGF-IGF1R), Results suggest that the joint effect of IGF-I and estrogens may provide novel methods of breast cancer risk reduction among women., Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma., Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival, results suggest a strong correlation between IGF-I and height, weight and protein catabolism and emphasize the need to normalize IGF-I levels in children with cystic fibrosis., Presence of irregularity in region between -1115 and -784 nt in P1 promoter of insulin-like growth factor-1 gene may indicate beneficial effect on coronary arteries in a group of patients with stable angina., Genetic and lifestyle chronic disease risk factors influence IGF1 and IGFBP3 circulating levels differently in African Americans and whites., IGF-I induces a temporally regulated nuclear or cytoplasmic localization of IRS-1 that correlate with the transition from proliferation to chondrogenic differentiation., IGF-1 gene polymorphism in obese patients with insulin resistance, was investigated., Acne is proposed to be an IGF-1-mediated disease, modified by diets and smoking increasing insulin/IGF1-signalling., The results of the study add further evidence for an adverse effect of elevated IGF-I concentrations during early reproductive life on risk of breast cancer., Review, Smooth muscle cell hyperplasia in stricturing Crohn disease is regulated by increased endogenous IGF-I and alphaVbeta3 integrin ligands that regulate augmented proliferation and diminished apoptosis, Intrauterine growth restricted neonates demonstrate increased IGF-1 levels., In adolescents with type 1 diabetes and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis, Partial primary deficiency of insulin-like growth factor (IGF-I) activity associated with IGF1 mutation demonstrates its critical role in growth and brain development., the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements., Body mass index contributes to racial differences in IGF1, Depressed levels of ghrelin in children with adenoid and tonsillar hypertrophy lead to decreased appetite and insufficient energy intake. Lower serum levels of IGF-1 in these children may be secondary to deficient growth hormone stimulation by ghrelin., Patients with coeliac disease showed lower IGF-I levels., These data show that CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations, and suggest that IGF-1 is unlikely to be etiologically important in relation to CWP., IGF-1 bioavailability, represented by the free IGF-1 levels, correlated with ALS severity; high levels of the free IGF-1 in sALS might reflect a physiological defensive mechanism promoted in response to neural degeneration and/or muscle atrophy, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men., IGF1, IGFBP1 and IGFBP3 genetic variants may have roles in ovarian cancer risk, IGFBP-3 and IGF-1 decreased significantly following regular physical activity in children and adolescents with type 1 diabetes., In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF, Aurora-A, via activating Akt, stimulated nuclear factor-kappaB signaling pathway to promote cancer cell survival., IGF-1 is a mitogen for retinal pigment epithelial cells and also stimulates production of the angiogenic factor, vascular endothelial growth factor (VEGF)., Metformin reduces cell growth, protein synthesis, MAPK3/1, and P90RSK phosphorylation in response to IGF1 through an AMPK-dependent mechanism in cultured bovine granulosa cells., In older men, both lower and higher IGF1 and IGFBP3 levels may be metabolically unfavourable risk factors, These results suggest that positive feedback regulation of bFGF and IGFs leads to proliferation of hUCB-MSCs., The anticancer effects of RA are mediated by inhibition of the secretion and synthesis of IGF-I, and involve a PKC-delta-dependent mechanism., Serum IGF-II levels, which appeared to be negatively correlated with elevated E2, decreased in polycystic ovary syndrome patients early after hMG & hCG administration when monitored for 24 h, while no such changes were observed in IGF-I & IL-6., The levels of growth hormone-insulin-like growth factor-1 in neoplastic patients were also inversely correlated with disease progression., significant inverse associations of body mass index with IGF-1 (insulin-like growth factor 1) levels and do not support hypotheses that associations of excess weight with specific cancer diagnoses are mediated through high IGF-1 levels, The growth hormone/insulin-like growth factor 1 axis is not only involved in brain growth, development and myelination, but also in brain plasticity as indexed by neurogenesis--REVIEW, Circulating 25OHD amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation., Studies provide further evidence for a role of the IGF-1R in skin, and imply that reduced expression of IGF-1 in geriatric skin could be an important component in the development of aging-related non-melanoma skin cancer., The growth hormone-insulin-like growth factor system is impaired in motor neurons and degenerating muscle fibers during amyotrophic lateral sclerosis., no association found between polymorphic VNTR [(CA)n repeat] and schizophrenia, Although (CA)n repeats polymorphism in IGF-I gene might affect prenatal growth in AGA children, our results have not shown any impact of variable number of (CA) n repeats in IGF-I gene on postnatal growth, IGF-1 was significantly higher in serum of Henoch-Schonlein purpura patients than in controls., The presence of a well-studied and common GHR polymorphism does not appear to be responsible for the variability of growth delay observed in patients with Cushing disease., Resutls shoe that the expression level of hIGF-I determined by ELISA was about 2440 pg/g of silk gland of the transgenic silkworms of the G1 generation., GH enhances the local formation of IGF-1, which activates fibroblast proliferation and keratinocyte migration., Resistance training initiated in the acute post-operative phase is highly effective in increasing mean fiber area and in addition induces marked increases in the expression of IGF-I splice variants., Weak evidence that genetic variations in IGF1, IGFBP1 or IGFBP3 may be related to mammographic density was found in breast neoplasm patients., disruption of phosphoinositide-dependent kinase-1 interaction with IGF-1R reduces IGF-1 survival effects in cancer cells, Results describe the associations between plasma IGF-I versus interleukin 6 (IL-6) and the acute phase proteins high sensitive C-reactive protein (hsCRP) and YKL-40 in a population-based study comprising 629 individuals, aged 50-89 years., Results show that p66(shc) binds to Src through a polyproline sequence motif contained in the CH2 domain, a unique domain in p66(shc), and IGF-I stimulates this interaction., IGF1 reached peak levels at around 13 yr in boys and 11 yr in girls. . At each corresponding age, IGF-1 levels tended to be higher in boys compared to girls., Higher serum IGF-I in older men is associated with increased risk of cancer death, independent of age, adiposity, lifestyle, and cancer history., IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in multiple myeloma cells, Data report that activation of P2Y(2) receptors by extracellular UTP inhibits the IGF-I-induced p110alpha-PI3K activation., Host-derived Ang-1 and IGF-1 mRNA levels were downregulated by cyclopamine in the tumor xenografts, Studies indicate that insulin/IGF-I and other genes converge and play partially overlapping roles in regulating aging and stress resistance in higher eukaryotes., High IGF-1 is associated with resistance to anti-EGFR monoclonal antibodies in K-RAS wild type colorectal cancer., Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1, stimulatory activities of pituitary Growth Hormone and IGF-I (insulin-like growth factor 1) on both Progesterone and human chorionic gonadotropin secretion parallels stimulation of cell proliferation and apoptosis inhibition in choriocarcinoma cells, Plasma acid-labile subunit is positively associated with prostate cancer risk, and may interact biologically with IGF-I to affect carcinogenesis, Our findings suggest that rs5742714 in IGF1 may be a genetic modifier for NSCLC prognosis in this Chinese population, especially among patients with surgical operation., intracellular IGFBP-2 regulates caspase-3 expression and contributes to the inhibitory effect on apoptosis independent of IGF, Findings suggest that common genetic variation in the IGFBP1 gene is weakly related to IGF-I levels and mammographic density., Compared to their partners, the offspring of nonagenarians had similar non-fasting serum levels of IGF-1, IGFBP3 and insulin but lower non-fasting serum levels of glucose, indicating that longevity is associated with differences in insulin sensitivity., Insults or stress in early life may affect the synthesis of IGF-1, which might play a role in reduction of certain cognitive functions in children with infantile spasms., Increased IGF-1 might be an interesting serum marker for early Parkinson disease and potentially for subclinical dopaminergic dysfunction, coordinated regulation of IGF-1/AKT/mTOR pathways and the endosomal compartment by the p53 pathway integrates the molecular, cellular, and systemic levels of activities in response to stress [review], A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci., Plasma IGF-I concentrations correlate with mean 24-hour somatotropin concentrations., GH1 Promoter SNPs 6, 8 and 9 were associated with height and IGF-1 levels among patients, and SNPs 6 and 11 with height in controls., no associations between IGF1 promoter region polymorphisms and body composition in early childhood, Three of four angiogenic factors, VEGF, b-FGF and IGF-I, are higher concentration in human milk which collected from preterm mothers than those of terms., Integrative genomic analysis showed enrichment of activation of IGF signaling in the Proliferation subclass of hepatocellular carcinoma, Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells., The IGF-I transgene produced a marked brain overgrowth, and significantly accelerated tumor development, increasing the frequency of pre-neoplastic lesions as well as full medulloblastomas in Ptc1+/-/IGF-I Tg mice., Strong associations of low serum IGF-I with blood pressure and arterial stiffness in young Africans suggest that the loss of cardiometabolic protection by IGF-I could predispose them to earlier cardiometabolic disease onset., Provide evidence that in an acute inflammatory condition, IGF-1 may have severe, harmful effects on the developing brain., IGF signaling significantly increased osteogenesis in human adipose-derived stromal cells and may be used for tissue-engineering purposes., IGF-1 plays a vital role in macrophage migration critically implicated in tissue inflammation., ste20-like kinase MST2 is regulated by the IGF1-Akt pathway, Primary analyses identified only nominally significant associations (P0.05), Results show that no significant difference was observed in IGF-1 between Responders and Non-Responders, however, IGFBP-2 was significantly lower in Responders., inhibiting GSK3 increases brain insulin-like growth factor I levels, alkaline phosphatase, IL-6, TNF-alpha, and bilirubin, but not IGF-1 or osteocalcin may play a role in hepatic osteodystrophy and liver cirrhosis, The data provide evidence that IGF1 may be an independent modulator for HDL-C in nondiabetic individuals., IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction, AMPK functions to inhibit IGF-I-stimulated PI3K pathway activation through stimulation of IRS-1 serine 794 phosphorylation., Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells, Link lower concentrations of circulating IGF-1 or its unbound fraction (IGF-1, higher IGF-I and IGF-IR contents observed in small for gestational age placentas and the lower contents observed in large for gestational age placentas compared with adequate for gestational age placentas may be influencing human fetal growth., Lean mass, aerobic fitness, and upper and lower body strength increased due to an 8-wk training program without concomitant increases in either circulating bioactive or immunoreactive IGF-I or insulin-like growth factor binding proteins., The simultaneous determination of serum AFP, ferritin and IGF-1 may help in differential diagnosis of liver diseases., obese patients with OSAS show a peculiar reduction of both spontaneous and stimulated GH secretion coupled with reduced IGF-I concentrations and impaired peripheral sensitivity to GH.[review], The plasma IGF1/IGFBP3 ratio was associated with bone mass acquisition in this period, and it may thus serve as a surrogate marker of bone mass gain in this population., characterizes the behavior of serum IGF-I and growth hormone in acute and late phases after aneurysmal subarachnoid hemorrhage, There is no significant association between IGF-i and cancer mortality, genetic association between IGF-1 and high-grade myopia in Caucasians, Brief, high intensity exercise does alter IGF-I bioactivity, IGF-1 is strongly associated with low-grade prostate cancer., A comprehensive analysis, between common genetic variation in the IGF1, IGF binding protein (BP) 1, and IGFBP3 genes with IGF-I and IGFBP-3 blood levels, and prostate cancer (PCa) risk, among Caucasians, was conducted., Decreased serum IGF-1 levels were associated with hepatocellular carcinoma and the decrease was remarkably noted in those patients concomitant with chronic hepatitis C., High concentrations of IGF-I mat play a permissive role in progression of stent restenosis after stenting of a myocardial infarct-related artery., In an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females., Data suggest that the inhibitory effect of chronic arthritis on skeletal muscle is higher in fast glycolytic than in slow oxidative muscle and that IGF-I administration attenuates this effect and decreases atrogin-1 and IGFBP-3 gene expression., Exercise and fasting increase IGF-1 mRNA expression., Demonstrate the feasibility of IGF-1 expression through AAV-mediated gene transfer of skeletal myoblasts and the beneficial effects of prolonged IGF-1 secretion in vivo on neovascularization, cell proliferation, and reduced apoptosis., serum IGF-1 level does not help as a serum tumor marker in bladder cancer patients., Findings in patients with Huntington's disease suggest that a high level of insulinlike growth factor I is associated with greater declines in executive function and attention., IGF-1 was not correlated significantly with measured strength parameters in physically active postmenopausal women., High expression of MMP-2 and IGF-1 proteins is significantly correlated with the invasion and metastasis of gastric carcinoma., study describes two children with severe short stature and a maternally derived novel heterozygous mutation in exon 3 of the IGF1 gene and their relatives, Repeated bouts of conventional resistance training resulted in a summative increase in the expression of alternatively spliced IGF-1 mRNA only in the older group., The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling., Data show that rosiglitazone reduces serum IGF-I concentrations in patients with uncontrolled acromegaly under conventional medical therapies, likely acting on the GH-dependent hepatic synthesis of IGF-I., Data suggest that 25-(OH) vitamin D3 status may contribute to determine serum IGF-I levels in healthy population., Obese individuals who are at greatest risk for cardio-metabolic and renal diseases may be identified by plasma level of IGF1; data suggest that lower levels of plasma IGF1 could contribute to reduced glomerular filtration rates., IGF-1 was lower in severe preeclampsia patients., height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers, High-intenstiy training/acidosis is a stimulus for exercise-induced cortisol/hGH secretion, but not for IGF-1 and IGFBP-3 secretion., Both birth-weight and cord-blood IGF-I are predictive of subsequent catch-up growth in monozygotic twins., Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, EGF and IGF-I may constitute new additives to University of Wisconsin solution in steatotic and nonsteatotic liver preservation., IGF-1Ec transcript might generate, apart from mature IGF-1 peptide, another posttranslational bioactive product that may have an important role in endometriosis pathophysiology, Let-7a may up-regulate the expression of IGFs in cancer cells, which is different from its inhibitory effects on other oncogenes, A dependence of insulin-like growth factor (IGF) signaling on active HH/GLI1 in glioma stem cells, is described., data show level of circulating GH/IGF1 is positively associated with local IGF1 mRNA expression in musculotendinous tissue when comparing acromegalic and GH deficient patients; results indicate collagen-stimulating role of local IGF1 in connective tissue, Based only in the amount of information, evidence portraying IGF-I as a wide spectrum neuroprotective agent greatly outweighs observations documenting the opposite., A lower blood IGF-1 levels were seen in non-variant carriers (homozygous genotypes for 19 or 21 repeats of GC) when compared to the variant group in angina patients., The response of human mesenchymal stem cells (hMSCs) was studied in culture with mechano-growth factor (MGF), an isoform of IGF-1 known to be expressed in the heart following injury., Data indicate after 3 cycles of treatment IGF-1 significantly declined, IGFBP-1 significantly increased, and IGF-2 and IGFBP-3 were not significantly changed., At peak exercise performance, in women IGF-I showed significant associations to peakVO and maximum power output, IGF-I/IGFBP-3 ratio was associated with maximum power output., Patients with 194 bp genotype are the resistant patients with active disease and they required high dose medication., P. acnes can induce the formation of comedones by stimulating the IGF/IGF-1R system, IGF-I expression was lower in the growth restricted infants as compared to the normal control group, Circulating bioavailable IGF-I has a moderate association with physical activity-induced increases in FFM accretion in young, healthy women, and this association is greater than observed for total IGF-I., Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3beta/JNK signaling., Pulsed magnetic field therapy increased the IGF-1 level in the CSF of patients with brain injury., By integrating androgen, IGF-I and beta-catenin signaling pathways, these data reveal that androgen-induced PSA expression requires activation of androgen receptor., Single nucleotide polymorphisms in IGF-1 is associated with myocardial infarction., significant increase of serum IGF-1 levels in patients with "3 vessel disease" and with high score in Gensini scale, In the present study, we observed associations between the IGF-1/1R pathway, susceptibility to IgAN, and the pathologic progression of childhood IgA nephropathy., GH/IGF-I axis plays an important role in skeletal development, linear growth, and the achievement of peak bone mineral density., Data suggest that low IGF-1 may be an important contributor to mild anaemia., body temperature plays an important role in myogenic differentiation of endotherms, but the sensitivity to low temperature could be buffered by certain factors in vivo, such as IGF-I and vitamin C., IGF I rather than insulin may be a physiological regulator of 2-deoxyglucose transport and glycogen synthesis in osteoblasts., Polymorphisms in IGFI and IGFBP-1 were not associated with endometrial cancer risk, but further research is needed., results strongly suggest that IGF-1 inhibits 5-fluorouracil induced apoptosis through increasing survivin levels, which prevents Smac/DIABLO release and blocks the activation of caspases, an age-related impairment of IGF-I expression and intracellular signaling does exist following injury, and potentially has a role in the impaired recovery of skeletal muscle with age, The number of human pancreatic islet cells expressing IGF-1 and EGF decreased significantly after the onset of Type 2 diabetes. Both may play a role in the function of the endocrine pancreas and in the pathogenesis of the diabetes mellitus., No association was found between IGF-1 levels and individual SNPs or diplotypes., Data suggest that diagnostic accuracy may be optimized if the GST is used when obtained serum IGF-1 concentrations are below 175 mug/l., Our data suggest that insulin receptor isoforms and IGF-I receptor play a role in the biology of follicular thyroid precursors, Report pituitary dysfunction and IGF-I levels following ischemic stroke., Older patients had a higher frequency of the AA genotype of IGF-1(-2995 C/A), while younger patients more often had advanced disease and mucinous adenocarcinoma., This study suggested that polymorphisms within the IGF-I gene could infer greater risk for Alzheimer disease., the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF, effect of second messengers on the expression of mechano-growth factor (MGF) synthesis by myoblasts and differentiated myotubes, In Sri Lankans intron 2 CT repeat polymorphism of the IGF-1 gene appears to be a significant contributor to IGF-1 levels and birth size in primiparous pregnancies., The haplotype T-19-A-T was significantly associated with serum IGF1 level., Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction., Polymorphisms in the IGFBP3 gene on chromosome 7p12.3 are associated with circulating IGF-I and IGFBP-3., no evidence that the severe short stature associated with heterozygosity for this novel IGF1 mutation in children born from a mother with the same mutation is caused by a dominant negative effect of the truncated protein, IGF-1 is an in vivo target of PPARalpha; a PPARalpha/IGF-1 signaling pathway is involved in the protection of cardiomyocytes under ischemic and hemodynamic loading conditions, In genetic association studies, no association was found between the IGF-I SNPs investigated (-603A>T; -553T>C) and endometriosis in a Korean population of women., IGF-I is associated with growth at an earlier postnatal age than nutrient intake and the effect of nutrition on levels of IGF-I may be restricted to the period of established catch-up growth., Sustained cardiac elevation of insulin-like growth factor-1 may not be beneficial in the setting of an acute ischemic insult., Lower IGF-1 expression is associated with tamoxifen-resistance in breast cancer., Studies indicate that appropriate consideration should be given to genetic defects in GH-1, IGF-I and GHRH causing growth hormone (GH) deficiency., Low IGF-1 is associated with sex differences in statural growth impairment in Crohn's disease., Data implicate IGF1 as a candidate gene to cause genetic susceptibility to bipolar disorder., we concluded that IGF1 SNP is not associated with either adolescent idiopathic scoliosis predisposition or curve severity in Japanese., Findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling., Growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1., This study is the first to demonstrate that K(+) channels such as hEag1 are directly involved in the IGF-1-induced up-regulation of cyclin D1 and E expression in MCF-7 cells., Combined treatment of hypothermia with recombinant human IGF-1 significantly protects the neonatal rat brain from hypoxia-ischemia., IGF-I enhances the migration of chondrosarcoma cells by increasing alpha5beta1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kappaB signal transduction pathway., in some cancers (Ewing's sarcoma) the transition to frank malignancy and poor treatment responsiveness seem to be associated with a reduction of IGF system activity, IGF1-derived MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, Elevated Nrf2 and IGF-1 may play important roles in promoting gastric tumor progression., Levels of circulating IGF1 are not associated with increased mortality in Australian men., The human longevity-associated IGF type-1 receptor (IGF1R) variants are reduced-function mutations, implying that dampening of IGF1 signaling may be a longevity mechanism in humans., Binding between insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 is not influenced by glucose or 2-deoxy-D-glucose, The current meta-analysis suggests that three IGF-I (CA) repeat polymorphisms had no association to breast cancer risk., Serum concentrations of insulin-like growth factor I and insulin-like growth factor binding protein 3 do not correlate with breast cancer development., IGF-1 activates methionine adenosyltransferase 2A (MAT2A) transcription by both known and novel pathways in cultured colon cancer cells., investigation of role of IGF-1 in regulation of TSP-1 expression, a U-shaped relation between IGF-I and all-cause mortality in male primary care patients., these results indicate that pharbin is an important negative regulator of IGF-1/PI3K/Akt signalling and protein synthesis., IGFBP-3 positively and negatively impacts on IGF1-induced lung cancer development., Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells, Homozygosity for the IGF1 192-bp allele is associated with a slower cranial growth from birth until age 5 years in individuals born very preterm., Data suggest that during androgen-deprivation therapy (ADT) with gonadotropin-releasing hormone analogues (GnRHa), IGF-1 possibly promotes luteinizing hormone (LH) production, although its role is unclear., IGF-I is positively associated with improved health and fitness outcomes in young, healthy men., an important step in understanding the differences of IGF-I and insulin receptor contribution to the in vivo activity of IGF-I. In addition, PEG-IGF-I presents an innovative concept for IGF-I therapy in diseases with indicated muscle dysfunction., these results integrate DNA damage resulting from genetic instability, IR, or chemotherapeutic agents, to ATM activation and abrogation of p53/NF-YA-mediated IGF-1 transcriptional repression, that induces IGF-1-sCLU expression., Data show that HLE-B3 cells express only the IGF-1Ea and IGF-1R transcripts., Data show that IGF-1 was only 1% lower in the highest compared to the lowest WHR quintile among subjects in the highest physical activity quintile., alpha-synuclein is a co-regulator of growth factor-induced AKT activation; elimination of alpha-synucelin reduces IGF-1-mediated AKT activation., the associations between serum concentrations of IGF-I and IGF binding protein-3 (IGFBP-3) and cardiovascular risk factors, Low IGF-1 is associated with recurrence in breast cancer., Polymorphic CA repeat length in insulin-like growth factor 1 is associated with breast cancer., Data show that orlistat is effective in inducing a weight-independent higher reduction in post-prandial NEFA levels than dietary treatment alone along with increase in GH peak, IGF-I levels, and IGFI/ IGFBP-3 ratio., A high soluble IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function., cerebrovascular disease and cardiomyopathy were associated with a significantly higher mean IGF-1 burden in treated patients with acromegaly, Data show that leptin is better than any other biological parameter for monitoring the efficacy of renutrition, including albumin, transthyretin, leptin, IGFBP-1, IGFBP-3 and IGF-1., Data suggest that the 737.738 IGF1 polymorphism appears to play a role on birth size and LGA-related metabolic outcomes., GH peaked at mid-puberty and IGF-1 in late puberty, P1NP and CTX were highest in mid-puberty compared with early and late puberty. GH, but not IGF-1, correlated with P1NP., IGF1 might inhibit insulinogenic differentiation of HEAC, whereas IGF2 enhances differentiation, and enhancement of IGF2 appears to be mediated via IR, IGF-I concentrations, are associated with modified risks of Prostrate cancer and benign prostatic hyperplasia, The data suggested that common variation in the IGF1 gene may affect maximal force production, which can be explained by IGF-1's role in the anabolic pathways of muscle. Variations in the IGF1 and IGFBP3 genes may result in higher body fat., Leptin and insulin growth factor 1 have roles in refeeding syndrome and mortality, The selected IGF-I and IGFBP-3 SNPs did not show any strong evidence for being associated with breast cancer risk., Data show a decrease in the growth of fibroblasts and in the expression of ILGF-1 and TGF-beta messengers in keloid and nonkeloid fibroblast after chronic exposition to hyperbaric oxygenation compared with normal oxygen partial pressure., Multiple sclerosis & higher disability seem to be associated with a reduction in bioavailability of IGF-I., These findings suggest that during puberty, circulating IGF-1 promotes bone periosteal apposition and mass accrual indirectly, probably through stimulating muscle growth., Insulin-like growth factor-I was present in knees with circumscribed cartilage lesions in a size-dependent manner. Insulin-like growth factor-I levels were correlated with indicators of pain perception., Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of retinopathy of prematurity, but more studies are needed., IGF-1 reduced ACCalpha phosphorylation via an ATM/AMPK signaling pathway and suppressed ACCalpha expression through an ERK1/2 transduction, playing a dual role in regulating ACCalpha activity and lipogenesis, Aging phenotype and its relationship with IGF-I gene promoter polymorphisms in elderly people living in Catalonia, Studies suggest targeting the IGF axis, either by anti-IGF therapy or via enhancement of peripheral insulin sensitivity, represents a viable therapeutic target in patients with prostate cancer., Despite a significant relationship between IGF1 genotype and knee extensor peak power at baseline, IGF1 genotype does not appear to influence changes in knee extensor peak power with ST., This study investigated the role of human insulin-like growth factor-1 (hIGF-1; encoded by the hIGF1 gene) on intervertebral disc degeneration., IGF-1 stimulated system xc-mediated cystine uptake in dental pulp cells and was protective against the toxicity of the glutathione synthesis inhibitor buthionine sulfoximine., genetic polymorphisms of IGF-I may have a substantial effect on recurrence for gastric cancer patients who have undergone curative gastrectomy, An inverse relationship was found between IGF-I concentration and melanoma, but clear associations were not observed between malignant melanoma and upper tertiles of IGFBP-3., Our results suggest that high serum IGF-I levels just after ischemic stroke onset are associated with neurological recovery and a better functional outcome., age related serum IGF-I concentrations were significantly lower in short thalassemic patients, with and without growth hormone deficiency, during childhood and adolescence, partial GH insensitivity at the post-receptor level may play a key role in IGF-1 deficiency described in thalassemic patients, Hyperglycemia induces a signaling switch in vascular endothelial and smooth muscle cells that results in enhanced sensitivity to the growth promoting effects of IGF-I., insulin-like growth factor 1 has a role in preventing acute coronary syndromes, In a porcine model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/HGF is a practical and effective strategy to reduce pathological cardiac remodeling., IGF-1 levels correlate with all individual Sexual Health Inventory for Men question scores., IGF-I and the IGF-I/IGFBP-3 molar ratio were positively, although not statistically significantly, associated with postmenopausal breast cancer risk., High IGF-I is associated with low-grade gliomas., After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1., These data show that IGF-I levels are reduced in subjects with nonalcoholic fatty liver disease and suggest that hepatic insulin resistance may affect IGF-I levels, Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in placenta from pregnancies with intrauterine growth restriction., Studies indicate there are four individual genes shown to impact life span and the aging process, showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes, Direct anti-inflammation might not be the primary mechanism for protection by recombinant human (rh)IGF-1, The present study suggests that lower IGF-I status is associated with higher fat mass, spleen longitudinal diameter, C-reactive protein and more severe hepatic steatosis., We genotyped single-nucleotide polymorphisms of IGF1, IGF2, IGF1R, IGF2R, IGFBP1, IGFBP3, IGFBP5, IRS1, IRS2, and IRS in pancreatic cancer patients, a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population was observed, The present study indicates that the activity of the growth hormone/IGF-1 axis is reduced in long-erm calorically restricted formerly obese humans., cross-sectional study to evaluate the effect of HCV infection on serum IGF-1, as well as to find out whether IGF-1 has a role in development of insulin resistance in HCV infection, Expression of IGF-1 seems to increase with tumor size in colorectal cancer., IGF-I can increase the stability of FOXA1 protein expression and place it as a critical mediator of IGF-I regulation of gene expression and IGF-I-mediated biological responses., study found a positive association between "ever increase" in IGF-1 or IGF-1/IGFBP-3 and the presence of colorectal adenoma, High serum IGF-1 levels were associated with an increased risk of Barrett's oesophagus., Integrins, in particular integrin beta3, are regulators of IGF-1, but not PDGF, signaling in osteoblasts., analysis showed a significant positive association between circulating IGF1 levels and risk of advanced colorectal adenoma, suggesting that IGF1 is associated with the pivotal precursor to colorectal cancer, Cardiac morphological data were negatively correlated with IGGBP-1 and positively correlated with IGF-I and birth weight., We have not found any association between the polymorphism CA repeats in the promoter P1 region of the IGF-I gene and suceptibility to HPV infection and cervical cancer development., Polymorphic variation in the IGF-1 gene is associated with extremely tall stature., Severe obstructive sleep apnoea syndrome could reduce plasma IGF-1 and DHEA-S levels in younger, but not elderly Japanese men, which is potentially associated with the development of metabolic abnormalities., Zyflamend inhibited Insulin-Like Growth Factor I stimulated cell growth, IGF Type 1 Receptor, and androgen receptor expression and its nuclear localization in CWR22Rv1 cells., Lack of IGF-I is unlikely to result in insulin resistance and thus supplementation of IGF-I is unlikely to improve insulin action in patients with cirrhosis., effect of mutations in IGF1 and IGF-1R genes are explained in terms of effect on ligand binding and receptor activation; severity of patient phenotype can generally be correlated to the effect of the mutation on protein structure and function [review], The results do not support an association of the SNPs rs6214, rs10860860, and rs2946834 in the IGF-1 gene with high-grade myopia and any myopia phenotypes in the Polish population., IGF-I correlates with systemic inflammation and seems to play an independent predictive role in metastatic non-small cell lung cancer., Lower circulating levels of IGF1 and IGFBP3 were independently associated with ARDS case status., Results indicate that in patients with severe growth hormone deficiency (IGHD), although the various IGF-I and IGFBP-3 genotypes may play a role in recombinant human growth hormone (rhGH) responsiveness, there was no effect on final height., a reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders, [review] Given the limitations of the IGF generation test (IGFGT) in the most severe cases of growth hormone insensitivity syndrome (GHIS), the ability of the IGFGT to detect less severe GHIS is doubtful., lower swerum levels in hepatitis C patients compared to healthy controls, The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner., Components of the IGF1 system may contribute to, or be a marker for, aortic dilation in ageing men., Increased IGF-1 concentrations in pregnancy complicated with GDM may partly reflect metabolic disturbances, especially insulin resistance and hyperinsulinemia, IGF-1 was associated with MetS independent of adiponectin, IGF-1 seems to be involved in prolonged growth restriction among low birth weight infants, regardless of whether they were appropriate or small for gestational age., examined the differential role of the IGF system in esophageal adenocarcinoma and squamous-cell carcinoma and its association with visceral obesity; results indicate IGF-1 axis has a key role in progression of esophageal cancer and represents a plausible mechanism through which visceral obesity impacts on esophageal adenocarcinoma risk and tumor biology, The inverse association between IGF-I serum concentrations and QTc interval in our study is suggestive of a higher risk for cardiac arrhythmias and thus might provide additional evidence for increased cardiovascular mortality in subjects with low IGF-I, analysis of induction of hair growth by insulin-like growth factor-1 in 1,763 MHz radiofrequency-irradiated hair follicle cells, While the association of intrauterine growth retardation (IUGR) and adult metabolic syndrome (MS), including diabetes, has been well documented, these subjects with normal IGF1 and insulin-resistant diabetes do not have typical manifestations of MS., Adaptive increases in IGF1 and IGF2 are observed in insulin resistance., expression of all IGF1 isoforms is hormonally regulated in MG-63 cells, Low serum IGF-1 is a risk factor for cardiac allograft vasculopathy in cardiac transplant recipients., The IGF-1 can promote the osteogenic differentiation and osteogenesis of STRO-1(+) PDLSCs via ERK and JNK MAPK pathway, suggesting that IGF-1 is a potent agent for stem cell-based periodontal tissue regeneration., The bench step exercise leads to improvements in not only the classical risk factors of atherosclerosis but also the arterial stiffness in elderly women, partly through NO production via IGF-1 bioactivity., Retinoic acid regulates prolidase activity in human dermal cells via IGF receptor signaling in photoaged skin., This study demonistrated that IGF-1 was significantly decreased in skeletal muscel in patient with amyotrophic lateral sclerosis., These findings do not provide evidence for a substantial influence of these common polymorphisms in the GH/IGF axis on objectively measured physical capability levels in older adults., Prospective associations of insulin, IGF-I, IGF-II and IGFBP-3 with physical performance in Caerphilly Prospective Study and cross-sectional insulin, IGF-I, IGF-II, IGFBP-2 and IGFBP-3 in the Boyd Orr cohort, were examined., Data suggest that the estradiol plasma level is correlated to circulating IGF-I, albeit the relation seems to be biphasic., A signature of high IGF-1 ligand was associated with better prognosis in breast cancer., It was shown that the PKCeta isoform is a negative regulator of the AKT signaling pathway. The IGF-I induced phosphorylation on Ser473 of AKT was inhibited by the PKCeta-induced expression in MCF-7 breast adenocarcinoma cancer cells., In children with preserved kidney function, the association between FGF23, uric acid, and IGF1 suggests that FGF23 could be an early nutritional indicator of high protein and phosphate intake, The role of functional-IGFBP3 for diagnosis of disturbances of the growth hormone/IGF hormonal axis appears to be limited., [review] Studies performed in patients with acromegaly assume an influence of exon 3-deleted growth hormone receptor (GHR) variant in the relationship between GH and IGF-I levels., There is a positive associations between serum IGF-I or the IGF-I/IGFBP-3 ratio with plasma aldosterone in women but not in men., IGF1 haplotypes are associated with genetic susceptibility to high myopia in Chinese adults, whereas IGFBP3 and IGFBP4 are unlikely to be important in the genetic predisposition to high myopia., Heavy smokers carrying susceptible IGF1, IGF2, and IGFBP3 polymorphisms have a higher risk of lung cancer., The mutation status of both EGFR and K-Ras could be a predictive marker of response to IGF-1R TKIs. Also, MEK antagonism can abrogate primary resistance of NSCLC cells to IGF-1R TKIs., These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in Type 1 Diabetic pregnancies., Janus kinase (JAK) 2 V617F mutation may have a role in primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hormone and insulin-like growth factor-1 concentrations during the follow-up, IGF-1R and IGF-1 are expressed in the majority of chordomas but IGF-1 expression is much stronger than IGF-2 expression., IGF1 and insulin levels are higher in girls with central precocious puberty compared with healthy controls after adjustment for age, bone age, and breast development., Greater IGF-I concentrations predicted greater anterior knee laxity across 20 menstrual cycle days., SCLU expression was stimulated by insulin-like growth factor-1, but suppressed by p53., Insulin-Like Growth Factor I showed modest non-linear associations with pubertal age, being low in women who first menstruated, and men whose voice broke, in the oldest respective age categories. In women it was negatively related to time to pregnancy., Associations between higher levels of IGF-I and adrenal androgens at age 8 yr with earlier menarche, independent of body size, support functional roles of these hormones in regulating puberty timing in girls., The pathomechanisms involved in the genetic defects at both ends of the GHRH-IGF-1 axis., Diagnosis and management of disorders of IGF-I synthesis and action., Our data demonstrate that the IGF-I system regulates GPER expression and function, triggering the activation of a signaling network that leads to the migration and proliferation of cancer cells., Among older adults, decreasing IGF-I level over time does not predict subsequent all-cause mortality, whereas increasing IGFBP-1 predicts increased risk of mortality., Estrogens exert their neuroprotective effect when IGF-1 levels are in the normal range. The neurotrophic activity of estrogen involves an interaction with IGF-I., The expression of IGF-1 and IGFBP-3 decreased in nonalcoholic fatty steatosis hepatocyte models., Data identified IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes by gene based association scan and gene expression analysis., The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2, and rs1457595 and rs17032362 in IGF1, with adult height in our study population., PAPP-A may first down-regulate expression of LXRalpha through the IGF-1/PI3-K/Akt signaling pathway and then decrease expression of ABCA1, ABCG1, SR-B1 and cholesterol efflux in THP-1 macrophage-derived foam cells., The polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population., The T allele of IGF1 rs6214 was specifically associated with thicker lens in a cohort of Chinese patients with myopia., High IL-6, IL-8 with low IGF-1 levels are found in adolescents with type 1 diabetes mellitus., discussion of role of IGF1 and growth hormone in brain/neuron function, development of or resistance to Alzheimer s disease (AD), and possibility of activation of these systems as targets in prevention/treatment of AD [REVIEW], IGF-I increased by 5.28 ng/mL (95 % confidence interval, Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition, epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 have an effect on human oocyte maturation and early fertilized and cloned embryo development, Diabetes was not associated with total IGF-I levels, but free IGF-I and diabetes had a significant association that varied by insulin levels above the median versus below the median, Wnt signalling in thyroid-associated orbitopathy pathogenesis is warranted., insulin-like growth factor-I has a role in mesenchymal stem cell-dependent fracture healing, study to evaluate association between CA repeats polymorphism of IGF-I gene in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival; results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival, Data show that the insulin-like growth factor-1 (IGF-I) (CA)(19) repeat was higher in White controls (50 %) than African American controls (31 %)., genetic association studies in a population of German children, Persistence of TGF-beta1 inhibited osteoblast differentiation via suppression of IGF-1 expression and subsequent down-regulation of the PI3K/Akt pathway., At the time of diagnosis, patients with acute leukemia showed a significantly increased level of IGF-1 as compared to controls, the differential associations between IGF-I and regional fat deposits, Thus, BDNF and IGF-I seem to act synergistically in the same cascade of transmission and neuroplasticity., Tobacco smoking during pregnancy decreases the pregnancy-associated plasma protein A and insulin growth factors I and II levels., a-SMN-dependent induction of CCL2 and IGF1 mRNAs results in increased intracellular levels and secretion of the respective protein products., data used to establish age- and gender-specific normative serum levels of IGF-I in Japanese population (0-83 years of age), discussion of general aspects of IGF-1/IGFBP (insulin-like growth factor binding proteins) system and role of IGF-1/IGFBP system in relation to physical exercise (type, duration, etc.) taking into account training aspects [REVIEW], IGF-1 released from the bone matrix during bone remodeling stimulates osteoblastic differentiation of recruited mesenchymal stem cells (MSCs) by activation of mammalian target of rapamycin., we have demonstrated that within a tight and physiologically relevant range, the IGF-1R plays a critical role in regulating basal NO bioavailability and insulin-mediated NO release., Associations of cord plasma IGFBP-3 levels and the IGFBP3 gene variants but not of IGF1 promoter and INS VNTR polymorphisms with IGF-I, IGF-II, or IGFBP-3 levels in utero., regulation of IGF-1 expression through an estrogen-responsive element-like site by BRCA1, The study determined that the redox potential of IGF1 is equal to -332 mV and the reduced form of IGF1 can bind cooperatively four Cu(+) ions, most probably into a tetracopper-hexathiolate cluster., PI3K activity bound to IGF-IR, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation., Changes in cerebrospinal fluid IGF-1 levels correlated positively with pain threshold in fibromyalgia patients during exercise., A novel heterozygous IGF1 splicing variant is associated with familial short stature in an extended family., This study suggests a possible association of the IGF-1 gene polymorphism with developing rheumatoid arthritis, particularly in males as non-carriers of the 192-bp allele., rhIGF-I could have a role in promoting overall hematopoietic recovery in mice after ionizing radiation and reducing the mortality when administered immediately post lethal irradiation exposure, a positive feedback between CD147 and IGF-I at the tumor-endothelial interface, The IGF-1/IGFBP-3 ratio, an indicator of free IGF-I levels, was significantly associated with increasing risk of all-cause mortality., Pyk2, which was strongly activated by IGF-I, was critical for IGF-IR-dependent motility., This study demonstrates that even minor changes in PA are associated with effects on serum levels of sclerostin, IGF-I, and bone turnover markers., The gene expression data from MGF-treated porcine satellite cells are in favor of a molecular model in which MGF inhibits porcine satellite cell differentiation., Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis., Data suggest that serum IGF1 (but not IGFBP3, insulin-like growth factor binding protein 3) is under control of glycemic index of diet; low glycemic load diet resulted in modest lowering of fasting serum IGF1 but had no effect on serum IGFBP3., Common IGF-1 and IGFBP-1/IGFBP-3 SNPs are not associated with body size in early life., Insulin-like growth factor-I regulates the neonatal immune response in infection and maturation by suppression of IFN-gamma., Circulating IGF-1 and CRP levels may have potential as indicators of exacerbation, malnutrition and muscle wasting in patients with COPD, demonstrates a novel mechanism in which IGF1 down-regulates E-cadherin expression through the activation of PI3K/Akt/mTOR signaling, These data indicate that exercise-induced increases in circulating IGF-I are not reflective of local IGF-I signaling., Ghrelin secretion is elevated in children with lower IGF-I/IGFBP-3 ratio. It seems that lower bioactivity of IGF-I is stimulating factor for ghrelin synthesis., The data suggest that ATM is a modulator of IGF-1 signalling downstream of insulin receptor substrate 1 in skeletal muscle., The triglycerides almost doubled the power of the variable B25 for predicting IGF-I levels and were found to have a highly significant, negative association with the IGF-I levels., Left ventricular hypertrophy (LVH) is accompanied by elevated resting serum IGF-1 and enhanced response to eccentric arm exercise. Findings suggest a role of IGF-1, possibly released from contracting muscle, in stimulating LVH in resistance training., Serum IGF-1 can be used as a short-term nutritional biochemical marker, as it was affected by a five-day high-energy regimen. IGF-1 levels decreased postoperatively in the control group, but there was no decrease in the hight-energy intervention group., Data suggest that only a fraction of circulating insulin-like activity is due to insulin itself; serum IGF-I and IGF-II may substantially contribute to insulin receptor signaling., IGF-1 inhibits H(2)O(2)-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. IGF-1's effect is, at least partially, regulated by miR-1 in induced pluripotent stem cells., the GHR and IGF1 genes may have a role in African pygmies' short stature., The secretion of IGF-I is affected by GH, IL-1beta and TNF-alpha., These results confirm our previous findings, wherein significantly higher levels of systemic IGF-1 were found in patients with advanced coronary atherosclerosis., results suggest that IGF1 polymorphism has a possible role in changing the genetic susceptibility to LOAD in a Han Chinese population., IGF1 plays a role in cerebral infarction in the Japanese., the partial recovery in muscle functionality and the full recovery in tendons response, suggests that mIgf-1 muscle specific over-expression exerts its effect on tendons either indirectly, improving the tendon viability and its functional properties, FAIM modulates IGF-1-induced Akt activation and IRF4 expression and has a role in multiple myeloma cell survival, IGF-1 appears as a positive indicator for severity of CAD assessed by the Gensini score, and thus its concentration may be an important indicator for assessing the extent of coronary artery involvement., Expression of the total IGF-1 mRNA and all splicing isoforms of IGF-1 mRNA decreased in colorectal carcinoma., IGF1 rs2946834 polymorphism is associated with clinical outcome of HER2-positive breast cancer patients., values for insulin-like growth factor 1 standard deviation score were significantly lower in patients with, than without adult growth hormone deficiency, These results demonstrate for the first time that IGF-1 induced MUC8 and MUC5B expression is regulated by activation of the ERK1 and p38 MAPK signaling pathway in human airway epithelial cells., Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line., variations in the levels of apelin and IGF-1 in retinopathy of prematurity, Data suggest that, in older adults, high-normal IGF1 serum levels are associated with prevalent metabolic syndrome (MS) and hypertriglyceridemia. MS is not mediator in U-shaped relationship of IGF1 concentration with incident cardiovascular diseases., Serum IGF-1 concentrations are not influenced in multiple myeloma patients., IGF-1 probably plays an important role in the genesis and development of certain solid cold thyroid nodules, including papillary thyroid carcinoma, nodular goiters, and Follicular adenoma., A selective IGF1-mediated inhibitory feedback follows growth hormone release and administration., Insulin-like growth factor 1 down-regulates programmed cell death 5 in osteoarthritis chondrocytes., Eb peptide localizes strongly to nucleoli and promotes cell proliferation., The stimulatory effect of follicle stimulating hormone on Cyp19 and AKT depends on IGF-I and on the expression and activation of the IGF-IR., analysis of 16 IGF pathway SNPs, including IGF-1 and IGFBP-3, reveals that prostate cancer risk varies by intakes of dietary protein, Benzo-a-pyrene exposure caused mutations of the IGF-1 gene in immortalized human trophoblast cells., The findings suggest that the decline of the circulating free IGF-I level, which derives from zinc deficiency, may contribute to hepatic steatosis and insulin resistance in patients with hepatitis C virus-related chronic liver disease., SNPs in lysosomal-associated transmembrane protein 4 beta (LAPTM4B) and insulin-like growth factor 1 (IGF1) were associated with both susceptibility to and curve severity in adolescent idiopathic scoliosis in Korea., Formula for small for gestational age infants should aim at maintaining normal IGF-I and high molecular weight-adiponectin levels rather than at normalizing body composition., Our results provide some support for the hypothesis that IGF1 signaling is an important factor in prostate cancer progression and suggest that targeting this pathway might be beneficial in prostate cancer treatment., This is the first study to demonstrate a relationship between serum IGF-1 and progression of motor symptoms in the early stage of Parkinson disease., IGF-1 and miR-483-3p belong to a new class of natural killer cell functional modulators and strengthen the prominent role of IGF-1 in innate immunity., Serum IGF-1 levels were not helpful in differentiating parasomnic pediatric patients with and without epilepsy., IGF-I showed the highest induction of osteoclast differentiation and osteolytic activity and at the same time, induction of proliferation and differentiation of osteoblasts, indicating it plays a main role in bone remodelling phases., IGF-1 R expression does not seem to be impaired in idiopathic short stature patients. ISS patients with low-normal BMI SDS also tend to display a relative IGF-1 resistance., This study investigated the relationships among IGF-I +1770, IGF-I +6093, and IGFBP-3 -202 genetic polymorphisms and CAD in Taiwanese population.Results showed a significant association between the IGF-I +1770 gene polymorphism and increased risk of CAD., Results are indicative of an operational WISP3-IGF1 regulatory loop whereby WISP3 preserves cartilage integrity by restricting IGF1-mediated hypertrophic changes in chondrocytes, at least partly, upon interaction with IGF1., Testosterone, growth hormone, and insulin-like growth factor 1 showed with distinct delivery patterns depending on the order of strength training exercises., This study shows the involvement of IGF-1 and resistin in these beneficial effects of moderate exercise in fibromyalgia, results suggest that IGF-I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients, Serum levels of VEGF, HIF-1alpha and IGF-I were significantly higher in the diabetic patients than in the controls., The IGF-I system is of significance in human Alzheimer disease. Resistance to IGF-I action may occur in early AD. Serum but not CSF levels of IGF-I were higher in AD patients compared to controls., Among healthy term infants in Belarus, an intervention that succeeded in improving the duration and exclusivity of breastfeeding did not prevent overweight or obesity, nor did it affect IGF-I levels at age 11.5 years, Inactivating mutations of IGFALS result in IGF1 deficiency associated with growth retardation and show the role of IGF1 in bone formation, insulin regulation and the pubertal process, in addition to its crucial effect on growth., Microglia are important sources of IGF1; microglial activation phenotypes can influence IGF1 expression., IGF1 caused randomly directed cell movement in multiple myeloma cells. It synergized with HGF and IGF-1 in inducing migration., Serum IGF1 is elevated in opiate dependence both absolutely and after adjustment for age, sex, and markers of immune and hepatic activation., IGF-1-induced delayed MET activation occurs in cell lines which express both receptors, suggesting that IGF-1R-mediated MET activation may contribute to tumorigenic properties of multiple cancer types when both growth factor receptors are expressed., The simultaneous reversion in expression of constituents of MHC-1 antigen processing path and up-regulation in expression of MHC-1 occurring with down-regulation in IGF-1 may have a role in reinforcement of immunity against tumor antigens in glioblastoma., Polymorphisms in the IGF-1, especially a haplotype in the LD block 3, are assumed to be genetic markers predicting the outcome of metastatic PCa., Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network., In patients with severe obesity, IGF-I z score and adiponectin correlate with parameters of cardiac remodeling independently of anthropometric, hemodynamic or metabolic factors, inhibiting autophagy mitigated IGF-1 knockdown-induced preservation of autophagic vacuole formation and inhibition of beta-gal accumulation in the presence of FFA in HepG2 cells, The results showed that the serum IGF-I concentration was elevated and correlated with clinicopathological parameters and overall survival (OS) in NSCLC patients., in this selected group of elderly women, we found a strong relationship of increased bone resorption, expressed as BMD, to calcium-regulating hormones PTH and IGF-I., Decreased IGF-I serum levels are associated with sepsis., Disruption of Nox4 recruitment to SHPS-1 in aorta from diabetic mice inhibited IGF-I-stimulated Src oxidation and activation as well as cell proliferation., In cirrhotic patients admitted to hospital due to complications of the disease, IGF-I and IGFBP-3 serum levels were associated with variables related to liver dysfunction and to more advanced liver disease., Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients., Blunted increase of IGF1 after the rGH generation test was present in children with Noonan syndrome due to mutations in the PTPN11 gene., Genotype 19/19 of IGF1 CA repeat polymorphism is a decreased risk for developing breast cancer in Caucasian but not in Asian., findings suggest that IGF-1A and IGF- 1B mRNA are highly coexpressesed with YB-1 mRNA in the mononuclear fraction of bone marrow aspirates in patients with multiple myeloma, In humans the age-associated loss of strength is associated with the levels of representative adipokines (adiponectin, leptin, resistin) and IGF-1., In light of the importance of IGF-1 and autophagy in the heart, we review here IGF-1 signaling and autophagy regulation in the context of cardiomyocyte nutritional stress., High IGFBP-1 and low IGF-1/IGFBP-1 ratio are associated with all-cause mortality in older population., Signalling pathways regulating muscle mass in ageing skeletal muscle involve roles in the IGF1-Akt-mTOR-FoxO pathway., IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of small intestinal neoplasms., 1) IGF1 induces signals under anchorage-independent conditions and that 2) R36E/R37E acts as a dominant-negative inhibitor of IGF1R (IGF1 decoy). Our results are consistent with a model in which ternary complex formation is critical for IGF signaling., IGF-I deficiency in cystic fibrosis patients demonstrates commensurate reduction both in the lung and the circulation., Estradiol and IGF-I induced the rapid association of ER to IGF-IR., IGF-I partly mediates protein-induced kidney growth in healthy infants., Delivery of the E-peptide ameliorated the decline in function and resulted in significant preservation of cardiac contractility., Our findings suggest that high levels of IGF-1 may be an important factor toward the evolution of Benign breast disease to breast cancer., Data suggest serum IGF1 level is down-regulated in children with new-onset type 1 diabetes; down-regulation of IGF1 level is profound in diabetic ketoacidosis (DKA); serum IGF-1 level is up-regulated with insulin therapy in both DKA/non-DKA children., The results of the present study using a Japanese subset do not support the proposal that the IGF-1 gene determines susceptibility to high or extreme myopia in Caucasians and Chinese., Data indicate the effects of accelerated early infant growth on IGF-1/IGFBP-3 axis in small for gestational age (SGA) infants., data demonstrate that the expression of IGF-IEc is positively-associated with more advanced stage and higher Gleason score of prostate carcinoma, The role of IGF-1 overexpression on skeletal muscle alteration due to hindlimb unloading, was tested., study provides functional data of IGF1 expression to show that microsatellite length polymorphism in noncoding regions is a functional element, and it may interact with SNPs in closed proximity in the regulation of gene expression, Low-baseline IGF-I levels independently correlated with shorter TTR and poorer survival in patients with early-stage hepatocellular carcinoma after curative treatment., genetic variation across several genes in the insulin/IGF-1 signaling pathway or related gene networks, namely, ATF4, CBL, CDKN2, EXO1, JUN. 2 marginal associations with longevity did not remain significant after correction for multiple comparisons, Polymorphisms of the (CA)n repeats of the IGF1 gene and a variable number of tandem repeats of the insulin gene, separately or in combination, did not influence pre- or postnatal growth, insulin-like growth factor 1 serum levels or insulin resistance., Low IGF1 expression is associated with chronic hepatitis C and hepatocellular carcinoma., Studies indicate that modulation of IGF-I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of growth hormone deficiency (GHD)., Low levels of IGF-I and IGFBP-3 observed in patients with advanced liver cirrhosis are corrected after liver transplantation. IGF-I and IGFBP-3 correlate negatively with MELD., IGF-I levels and particularly free IGF-I, estimated by the IGF-I/IGFBP-3 ratio, are positively related with PINP as a bone formation marker and CTX as a bone resorption marker in healthy adult men younger than 55 years and premenopausal women., Variants of the IGF-1-gene play an important role in regulating serum levels of the IGF-I axis but there is no gene-protein-interaction., High circulating IGF1 concentrations and mucosal IGF1R expression may play important roles in both the formation and development of colorectal carcinoma., The observed associations of hepatocellular carcinoma with prediagnostic SHBG, free testosterone and IGF-I concentrations are in directions opposite to that expected under the etiological hypotheses., Data suggest that low oxygen conditions inhibit IGF1 action in hepatocytes by up-regulating IGFBP1, especially up-regulating phosphorylated IGFBP1, which inhibits IGF1 action., A possible contribution for the relatively rare IGF-I TT genotype to endurance performance, and in particular to power sport excellence in Israeli athletes., when IGF-I was exogenously added,inhibition of IGF-IR and targeting of the JAK2/STAT3 signaling pathway can be a target for ovarian cancer therapy., IGF-1 mRNA levels are downregulated in gastric cancer patients who have minimal or no weight loss., Hypothalamic-pituitary-adrenal axis hyperresponsiveness and a less frequent suppression of the GH/IGF-1 axis in response to acute stress are possibly involved in delirium pathophysiology, Adult survivors of Wilms tumour showed better attainment of final height and relatively higher IGF1 levels than those of other cancer types who had significantly shorter stature and lower IGF1 levels than Dutch references., results indicate important interactions between signaling pathways activated by estrogen and insulin-like growth factor 1 which regulate alveologenesis in bovine mammary gland, Serum IGF-1 depends on level of immunodeficiency in HIV-infection and may provide a link between immune dysfunction and development of HIV-associated lipodystrophy, AIDS wasting syndrome, diabetes and/or cardiovascular diseases in HIV-infected patients., A higher rate of increase in circulating IGF-I is associated with a decreased risk for subnormal Mental Developmental Index at 2 y of corrected age., Decreased IGF-1 levels potentiate association of inflammation with all-cause and cardiovascular mortality in prevalent hemodialysis patients., The increase in myostatin and IGF-1 levels in Pompe disease patients may reflect muscle regeneration after ERT, miR-486 directly targets components of insulin growth factor (IGF) signaling including IGF1, IGF1 receptor, and phosphoinositide-3-kinase, regulatory subunit 1alpha (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer., We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones., Results indicated that systemic lupus erythematosus activity is affected by a modulation of the insulin-like growth factor-1 signal pathway and +3179G/A IGF-1R polymorphism., we suggest that as IGF-1 levels increase, the risk for bipolar I disorder substantially increases., Children with chronic kidney disease were able to respond to GH therapy with both growth and an increase in serum IGF-I levels, but the IGF-I generation test was not a good predictor of growth response in this cohort., growth hormone receptor, insulin-like growth factor-1 receptor and insulin-like growth factors binding protein-3 have a role in the pathogenesis of non-melanoma skin cancers, especially squamous cell carcinoma., The IGF axis might play a key role in tumor progression of esophageal carcinomas. The IGF-IR targeting strategies might thus be useful anticancer therapeutics for human esophageal malignancies., IGF-I is elevated in healthy boys with pubertal gynaecomastia compared with boys without gynaecomastia, commercial human serum spiked with IGF1 at different levels between 0.01 and 10.0 ng/mL was analyzed with good results., this study also provides first insights into a possible functional role of the previously uncharacterised IGF-I D-domain., Single nucleotide polymorphisms in IGF-1, IGFBP-3 and IGF-1R is associated with their circulating levels, but not with mammographic density features, higher serum IGF-1 levels in middle age are associated with risk of AD disease in older age, independent of APOE genotype., mutation of PTEN in human gliomas generates aberrant cell growth in primary astrocytes, even in the presence of wt PTEN, by recruiting through PKA an autocrine IGF-1 loop that generates a constitutive NFkappaB activity, Data suggest that serum levels of free IGF1 can be up-regulated by diet (here, a 3-serving increase in milk consumption by postmenopausal women); total IGF1 and IGFBP3 (insulin-like growth factor binding protein 3) levels in serum were unchanged., robust GH-stimulated hepatic Igf1 gene transcription utilizes tissue-specific mechanisms of epigenetic regulation that are established independent of GH signaling., IGF-I (rs6214) was not associated with colorectal cancer risk in an Iranian cohort., In incident dialysis patients, low serum IGF-1 associates with body composition and markers of mineral and bone metabolism, and it predicts increased mortality risk., This is the first report of a long non-coding RNA regulated by insulin/IGFs., Higher circulating IGF-I levels may increase risk specifically of receptor-positive, but not receptor-negative, breast cancer., the developmental efficiency of microsurgical enucleated tripronuclear embryos cultured with the epidermal growth factor, brain-derived neurotrophic factor, and insulin-like growth factor-1 combination was significantly increased, The combination of elevated IGFBP2 and reduced IGF1 levels at diagnosis of epithelial ovarian cancer could further facilitate the identification of a patient subgroup with the worst prognosis., IGF-1/IGF-1R signaling induces tumor-associated lymphangiogenesis and contributes to lymphatic metastasis of colorectal cancer., provide new insights into the role that Insulin/IGF-I signaling play during cancer progression through glycosylation modifications, CSF/plasma ration of IGF1 is reduced in Alzheimer disease patients compared to controls., IGF1(CA)19 polymorphism is a candidate gene for cancer susceptibility regardless of environmental factors, especially in Asians. (Meta-analysis), investigate the expression of IGF-1, IGFBP-3 and IGF-1R in STRO-1-positive dental pulp stem cells (DPSCs) and fully impacted wisdom teeth in relation to tooth development, At 6-8 weeks after birth, blood IGF-1 and VEGF levels are not significantly different between premature infants with proliferative retinopathy of prematurity and those without, low blood IGF-I is associated with atrial fibrillation in the elderly population and is an independent determinant of atrial fibrillation., In epiretinal membranes (ERMs), IGF1 and IGF1R mRNA levels were significantly higher in patients with diabetes compared to control subjects., IGF-1 gene did not show the association with MP., rs35767 polymorphism near IGF1 was associated with circulating IGF-1 levels, and insulin sensitivity with carriers of the GG genotype exhibiting lower IGF-1 concentrations and insulin sensitivity as compared with subjects carrying the A allele, IGF-1 plays a role in the pathogenesis of atherosclerosis; its polymorphism is associated with carotid intima media thickness and endothelium-dependent vasodilatation, LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle, At 12 months of age, dairy protein intake as a percentage of total energy was associated with IGF-1 in six-year-old girls., Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate cancer growth., When their age-dependent effects were examined, one SNP, rs855203, showed significant (p = 0.0009) age-dependent interaction effect on IGF-1 levels variation., Tobacco smoking during pregnancy increased serum PIGF levels in the final stages of gestation and has no effect on the concentration of VEGF, which may lead to an increase of trophoblast proliferation and uteroplacental dysfunction., low-oxygen tension regulates the fate of placental mesenchymal stem cells from early and late gestations in response to IGF-I, both independently and dependently, via specific signal transduction mechanisms, Expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma., Low IGF-I levels in very low birth weight infants are associated with hyperglycemia, increased morbidity, and reduced growth., serum level not correlated with all-cause or cardiovascular death in patients with lower-extremity peripheral artery disease, Data suggest that CCN5/Wisp2 (Wnt-1 inducible signaling pathway protein-2), minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1; this overexpression of CCN5 inhibits streptozotocin-induced apoptosis., Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population., Low IGF-1 expression is associated with insulin resistance in hepatocellular carcinoma., insulin, IGF-1 as well as IGF-1/IGFBP-3 ratio and the reduction of IGFBP-3 may be related to the initiation of colorectal cancer, but they are not related to the progression and outcome of the disease, Serum IGF-1 is a partial mediator in the age-related decline of bone health in men as determined by calcaneal ultrasound, The A allele of SNP rs6214 in the IGF-I gene was associated with esophageal adenocarcinoma, and with head and neck neoplasms in women., These data suggest that serum IGF-1 levels could be an important marker of beta-cell function and glucose as well as lipid metabolic responses during fasting., low IGF-1 levels predict life expectancy in exceptionally long-lived individuals., The association between depressive symptoms and cognition is stronger among older adults with lower levels of circulating IGF-1., In this review, we discuss the emerging evidence for a functional relationship between the IGF-I/PI3K/AKT/mTOR pathway and ASDs, as well as a possible role of this signaling pathway in the diagnosis and treatment of ASDs. [review], IGF-I regulates cystine uptake and cellular redox status by activating the expression and function of xCT in estrogen receptor-positive (ER(+)) breast cancer cells by a mechanism that relies on the IGF receptor substrate-1 (IRS-1)., EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway in multiple myeloma cells ., Our results suggest that microRNA-223 is associated with acute ischemic stroke and possibly plays a role in stroke through up-regulating growth factor such as insulin-like growth factor-1 gene., It is associated with adiposity and insulin resistance., Lower IGF-I levels are significantly related to risk of stroke, independent from other traditional and emerging risk factors, suggesting that they may play a role in the pathogenesis of AIS., IGF-1 serum concentration predicts post-load hypoglycemia following bariatric surgery, MRNA levels of IGF-1 and IGF-1R were significantly higher in colorectal cancer tissue compared with its non tumor tissue in patients with and without type 2 diabetes., IGF1 elevates cell proliferation and enhances cell cycle progression as well as the expression of cyclins D1 and D3 in pituitary cancer cells., Overexpression of IGF-1 stimulated cell proliferation and differentiation of neural stem cells., Data suggest that development of islet autoimmunity and thus diabetes type 1 is subtly affected by early infant growth, however, IGF1 and IGFBP3/insulin-like growth factor binding protein 3 appear unlikely to be in causal pathway., Serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder were significantly higher than those in healthy controls, After LT, GH levels correlate with the extent of cytolysis, while IGF-1 is an indicator of liver synthetic function recovery. IGF-1 levels >90 mug/L (day 15-30) seem to be an indicator of short-term survival., the increased miR-223 expression could impair the IGF-1-mediated IL-10 production in activated RA T cells in vivo, which might contribute to the imbalance between proinflammatory and anti-inflammatory cytokines., higher levels of IGF-I receptor stimulating activity are associated with higher prevalence and with a higher incidence of dementia; results suggest IGF-I increases in response to neuropathological changes in dementia and could reflect a state of IGF-I resistance in dementia, Human IGF-1 gene can be transfected into hUCB-MSCs, and expressed at a high level with subsequent expression of type II collagen, the data support an important role for IR/IGF-1R mediated activation of signaling pathways and improved mitochondrial and metabolic function in HD human lymphoblasts., alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts., Data confirm that plasma IGF1 levels are down-regulated in patients with type 1 diabetes; as the disease progresses, low IGF1 appears to indicate suboptimal diabetes management and increased insulin resistance., Changes in IGF-1 and its receptor on monocytes and granulocytes seem to be part of the mechanism that facilitates recovery from resistance exercise during earlier stages of muscle recovery., The importance of TOR signaling on the stimulatory role of amino acids and IGF-I in gilthead sea bream myogenesis, is reported., Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells., Recipients showed a rapid recovery of the GH/IGF1 hormonal axis and liver function after LDLT, whereas donors showed altered GH signaling and regenerative delay in the early days after living donation., Low serum IGF-1 levels are associated with acute ischemic stroke., Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected., ATM plays an important role in insulin-like growth factor 1 (IGF-1) expression, that in turn, regulates downstream secretory-clusterin induction during senescence., Insensitivity toward anabolic action of IGF-I in the growth plate in chronic inflammation is partially due to inhibition of IGF-I-specific signaling pathways by proinflammatory cytokines, affecting IGF-I-driven chondrocyte proliferation/differentiation., Data indicate there was no significant difference in both serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels between breast cancer (BC) patients., there is no evidence that IGF2 methylation was influenced by SNPs within the IGF1, IGF1R or IGF2R genes, which lie on other chromosomes., In this study the physiological effects of low and high IGF1 were examined in detail to infer mechanisms for their dichotomous effects on Anopheles stephensi mosquito resistance and lifespan; following ingestion, low IGF1 induced phosphorylation of midgut c-Jun-N-terminal kinase (JNK), a critical regulator of epithelial homeostasis, but high IGF1 did not., PTEN status in Ewing sarcoma affects cellular responses to IGFI and mTOR-directed therapy., These data provide evidence that IGF-1 promotes neurogenesis after traumatic brain injury., these results show that head and neck squamous cell cancer stem cells exhibit plasticity, with the maintenance of the stem cell fraction dependent on the EGF and IGF pathways, Low 192-192 genotype frequency of IGF-I gene was associated with low response to chemotherapy in congenital adrenal hyperplasia., basal levels of Rap1 activity holds up cell adhesion, whereas sequential regulation of C3G and GAP by IGF-IR reverses the labile Rap1 function from supporting adhesion to promoting migration., High IGF-1 expression is associated with hepatocellular carcinoma., Both low and high serum IGF-1 levels are risk markers for cardiovascular disease events in elderly men., p53 acts as a molecular switch in monitoring IGF-1-induced proliferation and premature senescence, and suggest a possible molecular connection involving IGF-1-SIRT1-p53 signaling in cellular senescence and aging., Expression of local IGF-1 in primary tumor tissue appears to significantly affect the aggressiveness of osteosarcoma., TGF-beta and IGF signaling have roles in regulating adjacent stroma cells in prostate cancer development and progression [review], GH and IGF-1 suppression is maintained for up to 25 months during pasireotide LAR treatment of acromegaly., the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels in ovarian cancer cells, This study provides initial evidence that protein normalized IGF-1 and IGFBP-3 and leptin levels increase in synovial fluid of women but not in men with OA versus those without OA., individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts, IGF-I is able to regulate fetal growth, through its up-regulation of the GLUT1 glucose transporter protein on the basal membrane of the syncytiotrophoblast., In women with normal somatotroph function, IGF-1 levels decrease in the first trimester of pregnancy., Data (including data from knockout mice) suggest reduced insulin/IGF1 signaling slows progressive neurodegeneration of aging and increases life span via mechanism involving IRS2 (insulin receptor substrate protein 2). [REVIEW], Data suggest that signaling/feedback via insulin and insulin-like growth factors (IGF1 and IGF2) is important during neurogenesis and in maintaining homeostasis of the central nervous system. [REVIEW], Serum levels of IGF1 were significantly higher in the group with the positive metastatic affection of the sentinel nodes than in negative patients., insulin-like growth factor-1 (IGF-1) in human CSF enhanced the migration capacity and increased the expression of C-X-C chemokine receptor type 4 (CXCR4) in both stem cell types., The blood proteins IGF1, IGF2, IBP2, IBP3 and A2GL have been proposed as indirect biomarkers for detection of GH administration and as putative biomarkers for breast cancer diagnosis., The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways participate in Perivascular adipocyte functions, which is activated by insulin-like growth factor 1(IGF-1) and inhibited by Gax., The combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels, were assessed., In conclusion, in nondiabetic patients with AS undergoing periodic anti-TNF-alpha therapy, IGF-1 and ADMA are inversely correlated., this study used immunohistochemical methods to demonstrate the presence of IGF-1, TGF-beta1, and VEGF growth factor receptors in normal, adenomatous, and hyperplastic parathyroid tissue., IGF-1 was the best predictor of the return of menses in female adolescents with AN or EDNOS., Locally secreted IGF-I in the semen may be involved in the pathophysiology of infertility in patients with varicocele., TM4SF4 expression was correlated with the increased expression of IGF1, consequently resulting in IGF1R activation in lung adenocarcinoma., Results show that higher prediagnostic fasting IGFBP-1 levels were associated with lower risk of prostate cancer, whereas higher IGF-1 levels were associated with increased prostate cancer risk., Down-regulation of IGF1 expression may be related to the etiology of poor sleep quality and chronic abdominal pain., Results show that IGF1 may not have a significant role in the biochemical and clinical outcome in acromegaly. The role of IGF1 polymorphism in acromegaly susceptibility needs further investigation., Negatively with circulating free IGF-I., Polymorphisms in IGF1 were not associated with patient's baseline characteristics in acromegaly., IGF-1 could promote proliferation and osteogenic differentiation of DPSCs via mTOR pathways, which might have clinical implications for osteoporosis., In children with low serum IGF1, genotyping contributed to a diagnosis of growth disorders., there was a positive correlation between serum IGF-1 levels and presence of coronary artery ectasia (CAE), and high IGF-1 levels and low HDL levels were independent risk factors for the presence of CAE, The present work studied the effect of IGF-1 on lipopolysaccharide mediated pro-inflammatory cytokine expression and aromatase genes' expressions as well as proliferation of buffalo granulosa cells., IGF-1 and IGF-binding protein-1 have roles in metabolic syndrome and ECG detected left ventricular hypertrophy, Association of a low IGF-1 level with reduced cognitive function and gait speed, particularly with a combination of mild cognitive impairment and slow gait., Autocrine and paracrine IGF-I plays an anti-apoptotic role in tumour pathogenesis and in shaping the tumour microenvironment., role of IGF-1 in intervertebral disc homeostasis, Data suggest higher IGF-I levels in pregnancy may be associated with lower risk of invasive and endometrioid epithelial ovarian cancer (EOC)., These experiments revealed that the C-terminal activating region 2 domain of Epstein-Barr virus LMP1 increased the mRNA expression and the secretion of the ligand IGF1, which promoted phosphorylation of IGF1R., Data suggest BDNF levels are higher and IGF1 levels are lower in serum of patients with type 1 diabetes as compared with control subjects; high-intensity exercise/physical activity increases BDNF/IGF1 levels in comparable percentage in both groups., IGF-I production augments the production of glial-derived neurotrophic factor and accelerates neurite outgrowth., High insulin-like growth factor 1 is positively associated with estrogen receptor-positive breast cancer risk., Our results suggest that rs6214 on the IGF1 gene and rs2854744 near the IGFBP3 gene potentially play an important role with ASMI in Taiwanese older adults in a metropolitan area., IGF-1 reduces lipid oxidation and foam cell formation via downregulation of 12/15-LOX to prevent atherosclerosis., Distinct roles of IGF-1 isoforms in human cancer depending on the type of malignancy., Cytosine-adenine microsatellite repeat polymorphism in the P1 promoter region of the IGF1 gene is an independent predictive factor for age at natural menopause in Caucasian women., IGF-1 derived from adipose-derived mesenchymal stem cells might be responsible for the radioresistance of breast cancer cells., IGF-I receptor sequence changes are not the cause of growth disorders in the study group of children., This is the first demonstration of a spatial asymmetry in the expression pattern of Mstn/IGF-I in healthy hearts, which is likely to play a role in the different growth regulation of left vs. right ventricle, A positive feedback loop between IRF1 and miR-29b may contribute to the sensitivity of colorectal cancer cells to IFN-gamma by repressing IGF1., IGF-1/Akt/FoxO1 regulatory machinery appears to be a previously unappreciated signaling axis involved in the carcinogenesis of Gastric cancer., It is reported here that both splice variants of insulin/IGF1 receptor hybrids are activated by IGF1 with >20-fold higher potency than insulin., Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients, TNF-alpha or IGF1 modulate the miRNA biogenesis of some miRNAs via MAPK/ERK signalling., IGF-I concentrations measured by two automated immunoassays are not transferable. The results emphasize the need to express IGF-I concentrations in standard deviation score according to a matched normal population of the same age and gender., This study investigates whether lower IGF-1 concentrations are associated with prevalent and incident late-life depression over a 3-year period., Decrease in serum IGF-1 levels is associated with the development of hepatocellular carcinoma., Metabolic alterations in the brain during transition from pre-diabetes to overt type 2 disease are functionally associated with insulin, IGF-1 and leptin signaling systems. (Review), at the binding of the insulin-like growth factor to a cell surface, hemoglobin of erythrocytes alters its conformations and affinity to ligands., IGF-I and percentage of body fat mass may be significant predictors of BALP in obese during the prepubertal period, intracellular levels of IGF-1 and RAGE protein might regulate the final destiny of the ovarian cell populations prior and during folliculogenesis, possibly controlling the metastatic potential of OSC as well., Through identifying SNPs that are associated with QOL in men with prostate cancer, this study suggests a role for IGF-I in physical QOL outcomes., Co-ingestion of carbohydrate with branched-chain amino acids or L-leucine does not preferentially increase serum IGF-1 and expression of myogenic-related genes in response to a single bout of resistance exercise., Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A and regulates secretion of insulin like growth factor 1 (IGF-1) and is required for anchorage dependent growth., study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population, protein(s) that associated with RPTPbeta in response to IGF-I and IGFBP-2 in vascular smooth muscle cells, IGF-1 may play a role in AV pathogenesis through its role in keratinocyte proliferation, sebaceous lipogenesis, and androgen synthesis, it was concluded that TGF-beta1, IGF-I/IGF-IR and VEGF-A overexpression is associated with the presence of aggressive tumors, which exhibit an increased probability of metastasis, a poor response to treatment and reduced survival rate., Inhibition of IGF-1 receptor signaling significantly reduces the formation of optic vesicle and optic cups, while exogenous IGF-1 treatment enhances the formation of correctly laminated retinal tissue composed of multiple retinal phenotypes that, Genetic and epigenetic variation at the GHR and IGF-1 loci play a major role as independent modulators of individual GH sensitivity., The elevated IGF-I levels were significantly associated with depression and impaired treatment response., Differences in quantitative expression of IGF-1 mRNA isoforms in HCV-infected livers, as compared to the control, suggest that HCV may induce alteration of IGF-1 splicing profile., Our results suggest that metformin is a potent inhibitor of the IGF-1/IGF-1R system and may be beneficial in prostate cancer treatment., There was a positive correlation between the IGF1 levels of and those of inflammatory mediators in HIV Infections., The presence of hypertension significantly decreases IGF-1 myocardial expression., Study implicates a novel HDAC/IGF-1 epigenetic pathway in the regulation of hypoxia-induced pulmonary hypertension., RT-PCR analysis of retina lysates over time showed that the neurotrophic effects of IGF-1 were also attributed to down-regulation of inflammatory and to some extent, angiogenic pathways., Circulating IGF1 has a role in early development of Beta-cell autoimmunity., The mechanism linking the IGF-1/insulin signal and AGR2 promoter activation is important., Loss of IGF1 expression is associated with Colorectal Cancer., igf-i, IGF-II, TGF-beta1 and VEGF-A and its receptor in malignant tumor tissue, as well as increasedplasmin release from proenzyme and MMP-3 activationis apparently associated with the formation of pathogenic mechanism of vasculature development, IGF1 level is significantly lower in cancer-free BRCA mutation carriers versus BRCA-negative controls, and there is a potential association between estradiol and IGF1 in cancer-free BRCA mutation carriers, IGF1 Promotes Adipogenesis by a Lineage Bias of Endogenous Adipose Stem/Progenitor Cells., Logistic regression analysis revealed that there was no significant association between rs5742612 SNP and the risk of gastric cancer., Human osteoarthritic cartilage demonstrates the release of bioactive insulin-like growth factor-1 from a collagen-glycosaminoglycan scaffold, Serum IGF1 was increased in hepatocellular carcinoma patients compared to patients with liver cirrhosis, but lower than in healthy controls., The SNP rs6218 in IGF-1 3'-UTR, through disrupting the regulatory role of miR-603 in IGF-1 expression, might act as a gastric cancer tumorigenic factor., This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia., In morbidly obese young adults, insulin resistance and IGF-1 levels significantly associated with common carotid artery thickness, independent of other major cardiovascular risk factors., cord blood concentrations in intrauterine growth restriction clearly below those in appropriate for gestational age and small for gestational age neonates, plasma level not associated with endometriosis risk, CAV1 expression was positively related to IGF-1R expression in human hepatocellular carcinoma tissues; CAV1 confers resistance of hepatoma cells to anoikis by activating IGF-1 pathway., AEG-1 regulates IGF-1-induced proliferation and apoptosis via Erk1/2 and Akt signaling in CM development, which suggests IGF-1-AEG-1 signaling could be recommended to be a useful target to exert anti-tumor effects on cardiac myxoma, Polymorphisms of rs6214 and rs6218 in the 3'UTR of IGF1 are associated with acute lymphoblastic leukemia in chinese children, and the polymorphism of rs6218 is related with IGF1 expression at mRNA level., Results defined miR-28 as a critical regulator of IGF1 mRNA translation function; down-regulated miR-28 in hepatocellular carcinoma (HCC) was associated with tumor growth through PI3K/AKT pathway by targeting IGF1., Downregulation of IGF1 by the introduction of miR-1 attenuated the proliferation of the vascular smooth muscle cells, suggesting that IGF1 is a target gene of miR-1 and that the effects of miR-1 are mediated through IGF1., IGF-1 postoperative levels are correlated with the graft's quality and reflect liver function. Early IGF-1 recovery is associated with a higher 3-year survival rate after LT., Our study suggests that TT genotype and CT+TT genotype of IGF-I rs35767 were associated with risk of osteoporosis and bone mineral density levels, the TT genotype of IGF-I rs35767 was associated with an in-creased risk of osteoporosis., High expression of IGF1 is associated with triple negative breast cancer., Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells., Results indicate that increased IGF-1 levels after recurrent hippocampal neuronal firings might, in turn, promote seizure activity via IGF-1R-dependent mechanisms., Down-regulation of IR and IGF1R, achieved by insulin + fructose and monoclonal antibody treatments, results in decreased downstream signaling., Associations of lower IGF-1 with lower Broadband Ultrasound Attenuation, greater 3-year decrease in bone mineral density, and increased 10-year fracture risk were only observed in women, not in men, PAPP-A in ascites and tissue-associated PAPP-A serve to increase IGF bioactivity and, thereby, to stimulate IGF-IR-mediated ovarian tumor growth., Serum levels of IGF-1 were correlated with symptoms of depression and heart rate variability in mild traumatic brain injury patients., Paracrine engineering of explant-derived cells to overexpress IGF-1 provided a targeted means of improving cardiac stem cell-mediated repair by enhancing the long-term survival of transplanted cells and surrounding myocardium., Circulating levels of IGF-1, IGFBP-3 and their molar ratio were not associated with the risk of occurrence of colorectal adenoma (CRA), but IGF-1 was associated with increased risk for occurrence of advanced CRA, Results indicate that TGF-beta1-dependent IGF-IEc expression and MGF production in patients with fibrostenotic Crohn's disease regulates smooth muscle cell hypertrophy a critical factor that contributes to intestinal stricture formation., Shortened telomeres in acromegaly and cellular senescence induced by IGF-I can explain, in part, the underlying mechanisms by which acromegaly exhibits an increased morbidity and mortality in association with the excess secretion of IGF-I., anticancer effect of Evo in human colon cancer may be partly mediated by downregulating HIF-1alpha expression, which is initiated by inactivating PI3K/Akt signaling transduction though decreasing the expression of IGF-1 in colon cancer cells., IGF-1 and physical stimulation activate mTOR, thereby stimulating the rate of mRNA translation in osteoblasts., Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth., IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians, Patients with idiopathic normal pressure hydrocephalus had higher serum IGF-1 than controls., one development may be compromised indirectly via suboptimal IGF-1-dependent muscle development in insulin-resistant children, Type 1 diabetic women delivering large for gestational age infants had placental GH levels similar to women without LGA infants., our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk, Parkinson's disease patients had higher serum IGF-1 levels compared with healthy controls. (Meta-analysis), progression of lung cancer in mice treated with IGF-1 was significantly increased as compared to the group treated with IGF-1+AG1024 or the control group, with the same trend mirrored in IGF-1/p-IGF-1R/IGF-1R at the protein and/or mRNA levels, GH, IGF-1 and ISI-Matsuda index were lower in the high fatty liver index group in obese subjects with fatty liver and sarcopenia., Low-oxygen tension can modify the IGF-1 or IGF-2 signaling via the IGF-1R and IR in placental mesenchymal stem cells., Anoikis resistance of oestrogen-responsive breast cancer cells depends upon IGF activation of the type I IGF receptor and PI3-kinase/Akt pathway., The present study demonstrates that decreased circulating IGF-1 levels are involved in human and murine chronic liver disease, There was evidence for the involvement of PDGF, IGF-1, and EGF in primary pulmonary hypoplasia. PDGF deficiency plays a certain role in secondary pulmonary hypoplasia, Higher IGF-I levels among postmenopausal women and an elevated IGF-I, Metformin resulted in a significant reduction of IGF-1, IGF-1, no clinical significance of serum levels in ovarian cancer, miR-130b-3p was downregulated in IPF lungs. miR-130b-3p downregulation contributed to the activation of fibroblasts and the dysregulated epithelial-mesenchymal crosstalk by promoting IGF-1 secretion from lung epithelium., Full-length MGF directly stimulates the IGF-IR. Despite a higher EC50 concentration, at high equimolar concentrations full-length MGF showed a similar maximal potency to activate the IGF-IR as compared to IGF-I., Biliary levels of IGF-1 significantly increase in malignant biliary obstructions., We found differences in the relative expression of IGF-1A isoforms between the investigated groups., The established relationships suggests that the decrease of IGF-1 may represent the presence of syndromes of cytolysis and cholestasis in patients with NAFLD, type 2 DM and obesity., This article contains Scatchard plot data of affinity constant and binding capacity for IGF-I binding., IGF-1 and IGF-1 receptor may be involved in the pathogenesis of Graves' disease; IGF-1 and IGF-1 receptor act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells.,
OFFICIAL_GENE_SYMBOL IGF1,
OMIM_DISEASE Growth retardation with deafness and mental retardation due to IGF1 deficiency,
SP_COMMENT disease:Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation., function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity., online information:Insulin-like growth factor 1 entry, online information:The Singapore human mutation and polymorphism database, similarity:Belongs to the insulin family.,