Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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heat shock protein family B (small) member 2(HSPB2) heat shock protein family B (small) member 2(HSPB2) Related Genes Homo sapiens
CYTOBAND 11q22-q23,
ENSEMBL_GENE_ID ENSG00000170276, ENSG00000254445,
GENERIF_SUMMARY HSP27 and alphaB-crystallin are increased, phosphorylated and localized in aggresomes when proteasome activity is inhibited, HSP27 nuclear staining can serve as a sensitive marker for skin irritation or cellular stress in excised skin, HSP72 biosynthesis was analyzed by an image processing, computer-assisted imaging method in an endothelial vascular cell line and compared to a hand-calculated method. No differences were seen., Hsp27 regulates apoptosis through an ability to interact with key components of the apoptotic signalling pathway [review], hsp72 reduces caspase-3-mediated proteolysis of FAK, an anti-apoptotic protein, Hsp27 plays a significant role in the IFN-gamma-induced sensitization of oral SCC cells to anticancer drugs, Data show that heat shock protein 72 suppressed extracellular signal-regulated kinase activation by protecting dual-specificity phosphatases and suppressing MEK1/2., Associates with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation., down regulation in neuronal and non-neuronal cells expressing mutant ataxin-3, HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation, Phosphorylated HSP27 favors reduced bead motions that are probably due to stabilization of the actin cytoskeleton., HSP27 may provide a neuroprotective effect in AD and other tauopathies, KNG modulate bone marrow derived stromal/preosteoblast cell proliferation and suppress etoposide-induced apoptosis through ERK and HSP27 activation, respectively., Both heat and BPDE can induce the expressions of Hsp27 and Hsp70 in A549 cells., HSP27 is linked to multi-drug resistance in cell line HepG2/VCR., positive effect of Id-1 on TGF-beta1-induced cell motility was mediated through activation of MEK-ERK signaling pathway and subsequent phosphorylation of HSP27, a cellular defense against dysregulated proteins, in the form of Hsp27 and alphaB-crystallin, might contribute to the cell cycle reentry seen in AD cells., These data show that Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism., Upon heating at 43 degrees C, Hsp27 effectively suppresses myosin subfragment 1 aggregation, and this effect is enhanced by mutations mimicking Hsp27 phosphorylation., In a large cohort of type 1 diabetic subjects, we found an independent association between serum HSP27 and distal symmetrical polyneuropathy., These findings identify a novel pathway for vascular endothelial growth factor-induced HSP27 serine 82 phosphorylation via PKC-mediated PKD activation and direct phosphorylation of HSP27 by PKD., HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion., annexin II is a novel HSP27-interacted protein which is involved in UVC resistance in human cells, Mechanistic in vitro studies showed upregulated HSP27 expression and secretion in human macrophages treated with estrogen or acLDL., In conclusion, despite the protective action against acute motor neuron injury, Hsp27 alone is not sufficient to protect against the chronic motor neuron injury due to the presence of mutant SOD1., mRNA expressions of Hsp70, Hsp32 and Bax significantly increased in mononuclear blood cells after marathon running, whereas Hsp27 and Bad mRNA expression levels showed no significant changes., Pint mutations in patients with type 2 diabetes and their families were studied. mitochondrial genes including np3316, np3394 and np3426 in the ND1 region and np3243 in the tRNA(Leu(UUR))were screened., Overexpression of HSP27 in squamous cell carcinoma of the uterine cervix, HSP27 and HSP60 are predictors of biochemical recurrence of prostate cancer after radical prostatectomy., show that Hsp27 and actin are in the same complex in cells and that Hsp27 is important for cell motility., the differential expression patterns of alphaB-crystallin and Hsp27 indicate functional differences between these highly related proteins in placental tissues., data show islet protection in mice by human HSP27 by mitigation of apoptosis, possibly through nuclear factor kappaB regulation., Findings revealed a possible effect of HSP27 on apoptosis in metastatic HCC cells, in which HSP27 may regulate NF-kB pathway activation., findings provide the first evidence that expanded ataxin-3 interferes with Hsp27 synthesis, which may contribute to the impairment of the cells' ability to respond to stresses and trigger the progression of Machado-Joseph disease, Sodium salicylate can induce the expression of HSP27 in human lens epithelial cells., PM induces ROS generation in human lung endothelium, resulting in oxidative stress-mediated EC barrier disruption via p38 MAPK- and HSP27-dependent pathways., Overexpression of huHSP27 protects against hepatic injury and acute kidney injury associated with liver ischemia-reperfusion injury in mice., 5-fluorouracil & carboplatin specifically induce expression of Hsp27 in hepatoma cells. siRNA knockdown of Hsp27 diminishes survival of drug-exposed cells., Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) Increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in ovarian cancer., HSP27 and p53 protein levels play a key role(s) in heat shock-mediated switch of glucose depreivation-induced necrosis to apoptosis., study indicate that monocytes do not trigger apoptosis of vascular endothelial cells; proapoptotic activation mediated by PUMA seemed to be counterbalanced by significant increase of antiapoptotic HSP70, HSP27 and especially phospho-HSP27 proteins level, Reveal a novel function of HspB2 as an anti-apoptotic protein that negatively regulates apical caspase 3/8 activation in the extrinsic apoptotic pathway., HSP27 confers reresistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E, The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with lymph node metastasis in colorectal cancer., Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development bronchiolitis obliterans syndrome., analysis of CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients, promoter methylation of heat shock protein B2 is a novel molecular biomarker in human esophageal squamous cell carcinoma, Study shows that HspB2 oligomers exchange subunits., These findings provide novel insights into the role of p53 as a regulator of bidirectional gene pair HspB2/alpha B-crystallin-mediated ROS and the Warburg effect, Results suggest a limited function of alphaB-crystallin and HSP27 in preventing abnormal tau protein deposition in glial cells and neurons; in addition, the expression of alphaB-crystallin phosphorylated at Ser59 may act as a protective factor in glial cells., HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis,
SP_COMMENT similarity:Belongs to the small heat shock protein (HSP20) family., subunit:Associates specifically with myotonic dystrophy protein kinase (DMPK)., tissue specificity:Expressed preferentially in skeletal muscle and heart but not in the lens.,