Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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homeobox D10(HOXD10) homeobox D10(HOXD10) Related Genes Homo sapiens
CYTOBAND 2q31.1,
GENERIF_SUMMARY results indicate a role for HoxD10 in maintaining a nonangiogenic state in the endothelium, Missense Mutation in HOXD10 is associated with congenital vertical talus and Charcot-Marie-Tooth disease, An autosomal-dominant-inherited mutation in a HOXD10 gene with complete penetrance is found in all members of a pedigree with congenital vertical talus., No evidence was found of linkage near the HOXD gene cluster on chromosome 2q, suggesting genes other than HOXD10 are responsible for idiopathic clubfoot., Pak1 is a target of miR-7 and that HoxD10 plays a regulatory role in modifying the expression of miR-7., miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10, HoxD10 potentially functions as a tumor suppressor that is inactivated through promoter hypermethylation in gastric cancer., Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors., TBX1 can alter TGF-beta/BMP, an important signaling pathway, through interacting with HOXD10. Above findings may shed light on the mechanism of TBX1 mutations leading to renal malformations found in patients carrying a 22q11 deletion., downregulation of HOXD10 expression by miR-10b overexpression may induce an increase of pro-metastatic gene products, such as MMP14 and RHOC, and contribute to the acquisition of metastatic phenotypes in epithelial ovarian cancer cells, It is a member of the HOX gene family. HOX genes are the main regulatory genes that directly influence organogenesis and maintain the function of differentiated tissues, miR-23a was upregulated in glioma. This overexpression promoted glioma cell invasion, probably by modulating MMP-14 via directly inhibiting the expression of HOXD10., MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration., KLF4 and HOXD10 were identified as direct targets of miR-10b in bladder cancer cells, HOXD10 expression varies by stage of disease and produces differential effects in head and neck squamous cell carcinoma., Downregulation of the HOXD10 gene expression was associated with breast cancer., POU2F1 activity regulates HOXD10 and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype., These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for cholangiocellular carcinoma., Low HOXD10 promotes migration and invasion in gastric cancer.,
OMIM_DISEASE Charcot-Marie-Tooth disease, foot deformity of, Vertical talus, congenital,
SP_COMMENT developmental stage:Expressed in the developing limb buds., disease:Defects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as "rocker-bottom foot" deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity., function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., similarity:Belongs to the Abd-B homeobox family., similarity:Contains 1 homeobox DNA-binding domain., tissue specificity:Strongly expressed in the adult male and female urogenital tracts.,