Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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hypoxia inducible factor 1 alpha subunit(HIF1A) hypoxia inducible factor 1 alpha subunit(HIF1A) Related Genes Homo sapiens
CHROMOSOME 14,
CYTOBAND 14q21-q24,
ENSEMBL_GENE_ID ENSG00000100644,
GENERIF_SUMMARY hypoxic induction of the COOH-terminal transactivation domain (CAD) occurs through abrogation of hydroxylation of a conserved asparagine in the CAD, Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway., Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells, Review. HIF-1alpha is overexpressed in many human cancers and this correlates with disease severity. It controls expression of genes associated with angiogenesis and hypoxia resistance., Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells, carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP, up-regulates a series of genes involved in aerobic glycolysis during carcinogenesis, activation of HIF-1 is modulated by cytochrome P-450 reductase in cell membrane, Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013)., Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport, structure of an HIF-1alpha-pVHL complex determined; role of hydroxyproline, modulation of synthesis by sodium butyrate in colon cancer cell line HT29, Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family, crystal structure and basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL., Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells., Induction of leptin gene expression by hypoxia and HIF1., HIF-1alpha-prolyl hydroxylase, enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex, two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53, Human hormone-refractory prostate cancers can harbor mutations in the O(2)-dependent degradation domain., Data show that exposure of human colon carcinoma cells to insulin-like growth factor-1 (IGF-1) induces the expression of HIF-1 alpha, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene., Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization, REVIEW, HIF-1alpha expression related to increased angiogenesis in endometrial adenocarcinoma, In human cancer cells, both intratumoral hypoxia and genetic alterations affecting signal transduction pathways lead to increased HIF-1 activity, which promotes angiogenesis, metabolic adaptation, and other critical aspects of tumor progression., These results suggest that the expression of HIF-1 and VEGF induced by Cr(VI) may be an important signaling pathway in the Cr(VI)-induced carcinogenesis., transactivates the human leptin gene promoter, HIF-1 binds to Sp1 and regulates basal endoglin transcription in human and mammalian cells, results indicate that mitochondria-derived reactive oxygen species generated in response to hypoxia and increased accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) are not necessary for oxygen sensing in HeLa cells, Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin, Expression of hypoxia inducible factor-1 alpha and correlation with preoperative embolization of meningiomas., The binding of pVHL to HIF is governed by the enzymatic hydroxylation of conserved prolyl residues within peptidic motifs present in the HIFalpha family members., Hypoxic but not anoxic stabilization requires mitochondrial reactive oxygen species, HIF-1alpha is regulated by hypoxia through a PGE(2)-COX-2-catalyzed pathway in human tumor cells, autocrine regulation of TGF-beta2 production in endothelial cell hypoxia may involve cross-talk between Smad3 and hypoxia inducible factor-1alpha signaling pathways, HIF-1 alpha is correlated with apoptosis, but has no relationship with proliferation., HIF-1alpha is regulated and destabilized by ARD-1 mediated acetylation., HIF-1alpha is regulated by the von Hippel-Lindau tumor suppressor gene product, HIF-1 binds to FIH-1 in a specific binding site, HIF-1alpha is activated by p38, but it does not mediate induction of VEGF mRNA, data suggest a possible antiapoptotic role of HIF-1, ERKs and calcium are involved in the activation in cultured hepatoma cells, HIF-1alpha is regulated by nuclear factor kappa B during a microtubule-depolymerizing agent-induced signal cascade, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO, results indicate that oxidized low-density lipoprotein induced hypoxia-inducible factor-1alpha accumulation in human macrophages via a redox-mediated pathway, MAPK signaling facilitates HIF1a and HIF2a activation through p300/CBP, HIF-1 alpha can significantly suppress Mdm2-mediated p53 ubiquitination in vitro and blocks Mdm2-mediated nuclear export of p53, Loss of PTEN expression and increased levels of HIF-1alpha and VEGF may play an important role in carcinogenesis and progression of colorectal adenocarcinoma., This protein, dominantly expressed, reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism., Prolyl-4-hydroxylase PHD3 levels influence HIF-1 alpha stability in both normoxic and hypoxic conditions, suggesting that PHD3 may participate in a feedback loop controlling HIF activity., Overexpression of HIF-1alpha is associated with angiogenesis and tumor progression via regulation of VEGF in human colorectal carcinoma, data report a novel von Hippel-Lindau tumor suppressor-interacting protein (VHLaK) that functions as a negative regulator of HIF-1alpha transactivation; findings provide a novel mechanism for the modulation of HIF-1alpha transactivation by pVHL, ROS upregulate Rho protein expression and where active RhoA is required for HIF-1alpha accumulation during hypoxia in renal cell carcinoma cells, Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1., Loss of von Hippel-Lindau protein causes cell density dependent deregulation of cyclinD1 through expression of this protein., hypoxia-inducible factor 1 alpha is downregulated by FOXO4 in a von Hippel-Lindau protein-independent mechanism, hypoxia induced a biphasic effect via the PI3 kinase/AKT/GSK3beta pathway on HIF-1alpha stabilization with accumulation in early hypoxia, whereas prolonged hypoxia down-regulates HIF-1., role for VHL mutations promoting conventional clear cell renal cell carcinoma development by an impairment of HIF-1alpha proteolysis, Data show that hypoxia-inducible factor 1 alpha was stabilized in the von Hippel-Lindau gene product-deficient cell line 786-0 treated with a proteasome inhibitor or cobalt ion., HIF-1alpha and NF-kappaB have roles in transcriptional regulation of hypoxic conditions on mast cells, HIF1A is upregulated in rheumatoid arthritis and osteoarthritis., cross-talk between HIF-1alpha and Hepatitis B virus X protein may lead to transcriptional activation of HIF-1alpha target genes, which play a critical role in hepatocarcinogenesis, Quiescent hypervascularity mediated by gain of HIF-1 alpha function., sequence variation is associated with VO2 max before and after aerobic exercise training in older humans, thrombin-induced VEGF mRNA expression is associated with the regulation of HIF1A in vascular endothelial cells, insulin cannot stabilize the HIF-1alpha protein in human and mouse cells, HIF-1alpha is not regulated by her2/neu in Wilms tumor, The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia., functional requirement for HIF-1 activity was demonstrated in several different cancer cell lines, but AMP-activated protein kinase activation alone was not sufficient to stimulate the HIF-1 transcriptional activity, HIF prolyl hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia., signal transduction pathways involved in HIF-1alpha stabilization, HIF-1 DNA binding and transactivation by NO and hypoxia in microvascular endothelium, S-nitrosation of the HIF-1alpha C-terminal domain by nitric oxide derived from donors and nitric oxide synthase increases protein transcriptional activity., role of polymorphisms in generating individually different tumor progression, Constitutive expression of nuclear hypoxia-inducible factor-1alpha and secreted VEGF protein levels were significantly lower in IGF-IR dominant negative cells., Genetic variation was studied in HIF1A and there may be an association with high altitude adaptation in Sherpas., Overexpression of hypoxia-inducible-factor 1alpha in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage, Hypoxia-inducible factors 1alpha and 2alpha have roles in vascular endothelial growth factor expression and in nodular malignant melanomas of the skin, HIF-1 alpha was involved in mild hypoxia and hypoxia-mimetic CoCl2 induced leukemic cell differentiation., Among a panel of hypoxia-inducible genes, responses were critically dependent on Hif-1 alpha but not Hif-2 alpha in both endothelial and breast cancer cells but critically dependent on Hif-2 alpha in renal carcinoma cells., HIF-1alpha may play a critical role in the progression of pancreatic carcinoma., formation of stable protein-DNA complexes by DR/Arnt and HIF-1alpha/Arnt heterodimers with their cognate DNA sequences requires Per/Arnt/Sim A domains, hypoxic gene induction in cells expressing HIF-2alpha but not HIF-1alpha, regulation of HIF-1alpha by hypoxia and nitric oxide (NO) in explants of human cerebrovascular smooth muscle cells, Control of T cell survival via the HIF-1alpha-adrenomedullin cascade constitutes a novel milieu for regulation of T cell-mediated immune response in situ., results have shown that the destabilization of HIF-1alpha upon inhibition of mitochondrial respiration in hypoxia is dependent on prolyl hydroxylase activity, Both HIF-1 alpha and HK II protein expressions were co-localized in the cancer cells near necrosis, and the intensity of HIF-1 alpha protein expression was significantly correlated with HK II mRNA expression in both tumors., This approach supports a role of HIF-1alpha in oxygen-dependent cell cycle regulation, Here we found that hypoxia induces MKP-1 expression in human hepatoma cells HepG2 in a time-dependent manner., HIF1alpha is activated by ras-induced superoxides after shockwave stimulation, Noxa promoter responds directly to hypoxia via hypoxia-inducible factor (HIF)-1alpha., HIF-1a transactivation is not required for upregulation of VEGF by ionizing radiation in human glioblastoma, PI3K/Akt contributes to HIF-1alpha stabilization by provoking expression of heat shock proteins., Nur77 activated by HIF under hypoxic conditions regulates production of the peptide hormone precursor POMC., the cooperation of HIF-1 with Sp1/Sp3 confers transcriptional activation under hypoxia to RORalpha4, PKCzeta is responsible for the activation of HIF-alpha by inhibiting the mRNA expression of FIH-1 thus promoting the transcription of hypoxia-inducible genes., trans-regulation between HIF-1alpha and HIF-2alpha during hypoxia likely conveys target gene specificity, Assessment of HIF-1 alpha expression might be useful for predicting the prognosis of pancreatic cancer patients., Data show that oxygen deprivation cancer cells provoked decreased mRNA and protein levels of proapoptotic Bid and Bad, and that hypoxia-inducible factor 1 (HIF-1) was dispensable for the down-regulation of Bad but required for that of Bid., Results show that growth factor stimulation, overexpression of Akt/PKB, or loss of PTEN resulted in enhanced expression of both HIF-1alpha and HDM2., Overexpression of exogenous hHIF-1alphaTe resulted in the inhibition of the endogenous HIF-1 transcriptional activity, demonstrating that the testis-specific hHIF-1alphaTe isoform is a dominant-negative regulator of normal HIF-1 activity., HIF-1alpha expression correlates with Mutations of VHL gene play a significant role in the tumorigenesis of renal clear cell carcinoma ., effects of RNA interference targeting HIF-1 alpha messenger RNA on apoptosis in primary cultured human umbilical vascular endothelial cells exposed to anoxia and reoxygenation, HIF-1alpha induces cell cycle arrest by functionally counteracting Myc., Data indicate that HGTD-P is a new hypoxia-inducible factor 1 alpha-responsive proapoptotic molecule that activates mitochondrial apoptotic cascades., Hif-1alpha is expressed in the majority of patients with node-positive breast cancer. There was significantly shorter distant metastasis-free survival & disease-free survival in patients with increased hif-1alpha expression., Leu-574 is essential for recruiting HIF prolyl hydroxylases, thereby providing a molecular basis for modulating HIF-1alpha activity, Increased HIF-1alpha protein stability and enhanced HIF-1 transcriptional activity promote VEGF-A and ET-1 mediated increase of vascular permeability in donor lung grafts., In chronic lower limb ischemia, growth factor-1 (IGF-1) and IGF-2, were upregulated in atrophic and regenerating myocytes together with attenuated HIF, VEGF, and VEGFR-2 expression in the same cells., essential in changing the transcriptional response of tumours under hypoxia. It targets the transcription of over 60 genes involved in cancer biology including cell survival, glucose metabolism, cell invasion and angiogenesis., regulation of TGF-beta3 promoter activity by HIF-1 represents a mechanism for trophoblast differentiation during hypoxia., siRNA targeted degradation of HIF-1alpha and HIF-2alpha results in decreased hypoxia-induced PHD3 expression, Increased hypoxia-inducible factor 1, alpha subunit expression is associated with endometrial carcinoma, expression of HIF-1 alpha is increased in diverse Epstein-Barr virus (EBV)-infected type II and III cell lines, which express EBV latent membrane protein 1, HIF-1alpha expression in esophageal cancer was significantly and negatively related to resistsance to radiation and chemotherapy., HIF-1alpha expression may be used to refine the prognostic information provided by grade in patients with diffuse astrocytomas, IGF-II enhances the expression of VEGF in HaCaT cells by increasing HIF-1alpha levels., Inhibition of HIF-1alpha activity impairs gastric tumor growth, angiogenesis, and vessel maturation., upon activation by DNA damage, wt p53 mediates an accelerated degradation of HIF-1alpha protein, resulting in reduced activation of CA9 transcription and, correspondingly, decreased levels of CA9 protein, regulation of hTERT promoter activity by HIF-1alpha represents a mechanism for trophoblast growth during hypoxia and suggests that this may be a generalized response to hypoxia in various human disorders, HIF-1alpha and HIF-2alpha in renal cell carcinoma harboring VHL mutations do not have a major role in radiosensitivity, By regulating HIF-1 activity and specific gene expression downstream, NF-kappaB may influence the survival threshold, with an impact on the fate of carcinoma cells after prolonged hepatocyte growth factor treatment., most genes tested were responsive only to HIF-1alpha siRNA, showing no effect by HIF-2alpha knock-down, HIF1a and HIF2a are regulated by PHD1, PHD2, and PHD3, Hypoxia-induced ID2 expression could play a significant role in the previously observed dedifferentiation of hypoxic neuroblastoma cells, which in a clinical setting could lead to less mature and more aggressive tumors., HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with HIF-1alpha, HDAC7, and p300, M1- and M3- but not M2- or M4-AchR signals activate HIF-1 by both stabilization and synthesis of HIF-1alpha and by inducing the transcriptional activity of HIF-1alpha., cellular calcium chelation modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha, By using actinomycin D and cycloheximide we showed that A23187 induced HIF-1alpha mRNA expression., Nondiabetic patients had higher HIF-1alpha and VEGF expressions in myocardium compared with diabetic patients (P < 0.001)., Results show that breast cancer development is characterized by either nuclear loss or cytoplasmic translocation of CITED4, with consequent loss of hypoxia-inducible factor-1alpha transcriptional antagonist activity., Sp1 has a role in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism, Polymorphism of the HIF1A gene may confer susceptibility to renal cell carcinoma., HIF-1 mediates cell-autonomous activation of endothelial cells., Nur77 has a role in the stabilization of HIF-1alpha and in tumor progression and metastasis, Data suggest that vascular endothelial growth factor expression is inhibited via degradation of hypoxia-inducible factor-1alpha through interference with the function of heat shock protein 90., pfkfb3 is a hypoxia-inducible gene that is stimulated through HIF interaction with the consensus HRE site in its promoter region, VEGF and HIF-1alpha expression are inhibited by SU5416 through the inhibition of PI3K/AKT/p70S6K1 pathway in ovarian cancer cells, HIF-1alpha expression resulted in increased VEGF expression and the HIF-1alpha/VEGF pathway operates in angiogenesis in chondrosarcoma, Identification of HIF-1alpha417, a HIF-1alpha variant, which is required for transcription activity of aryl hydrocarbon receptor nuclear translocator., analysis of hydroxylation properties of amino acid substituted HIF-1alpha peptides, NaB suppresses HIF-1 transcriptional activity on hypoxia-responsive genes by reducing the HRE DNA binding activity under hypoxic conditions in intestinal epithelial cells, Hypoxia-inducible factor-1alpha (HIF-1alpha) mutation is a mechanism for enhancing HIF-1alpha activity in human prostate cancer and may increase tumor susceptibility or cause more aggressive biological behavior, HIF-1alpha(785) may play an important role in tumor promotion mediated by the Ras oncogene, phorbol ester or tumor growth factors, Propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O2 conditions, but not under 1% O2 conditions., Hyperglycemia impairs hypoxia-dependent protection of HIF-1alpha against proteasomal degradation and suggest a mechanism by which diabetes interferes with cellular responses to hypoxia., up-regulation of RhoA induced by low-oxygen conditions may play an important role in regulation of HIF-1alpha expression in trophoblast cells., HP2K enhancer is an HRE consensus motif that mediates increased transcription, under hypoxic conditions, via HIF-1, Analysis of furin promoters revealed the presence of putative binding sites for HIF-1; hypoxic/HIF-1 regulation of furin correlated with increased proteolytic activation of substrates MMP1 and TFGbeta1., specific association between pVHL and the hydroxylated HIF-alpha requires both the L1 and L7 loops to coordinate dynamic coupling among distant pVHL regions, The hypoxia-inducible factor 1 is a key regulator of oxygen homeostasis in the cell., other mechanisms than gene amplification must be responsible for HIF-alpha overexpression at normoxia, The HIF-1alpha ODD domain binds weakly to the isolated p53 core domain but tightly to full-length p53 to give a complex of one HIF-1alpha ODD domain with a p53 dimer., These results suggest a mechanistic link between succinate dehydrogenase mutations and HIF-1alpha induction., HIF1A is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer., PI3K signaling is required for HIF-1alpha accumulation and VEGF synthesis, role in expression of VEGF in cancer cells expressing her-2/neu oncogene, a functional interaction between pRB and HIF-1alpha is confirmed by showing that HIF-1alpha reverses the transcription repressor function of pRB., HIF-1 expression level can be an indicator of tumor radioresistance, Data indicate that HIF-1alpha is involved in tumorogenesis and progression of Renal cell carcinoma., angiotensin system system serves as a positive feedback loop and fosters pulmonary artery adventitial fibroblasts proliferation under hypoxic conditions with hypoxia-inducible factor 1 as the central effector pathway, HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas, hypoxia-inducible factor (HIF)-1 has a role in ceruloplasmin regulation, von Hippel-Lindau tumour suppressor protein regulates HIF-1alpha and its oxygen-regulated transactivation domains at high cell density., Important role in maintaining tissue integrity. We confirmed ischemic crisis in ischemic colitis at molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. May play important role in pathophysiology of ischemic colitis., HIF-1 activation induces substantial HO-1 expression that is associated with attenuated proinflammatory chemokine production by microvascular endothelium in vitro and in vivo., Tid-1(L) may play a critical role in pVHL-mediated tumor suppression by modulating the pVHL-dependent HIF-1alpha stability., Therapeutic and prognostic implication of somatic VHL alteration in renal cell carcinoma may be different according to the mutational subtype and the Pro582Ser change in HIF-1alpha may contribute to the development of metastases., first evidence that human hypoxia inducible factor 1alpha can be activated during physiologically relevant conditions, Detection of HIF-1alpha protein would seem to be of value in informing the prognosis of transitional cell carcinoma of the upper urinary tract., Review. The role of HIF1-alpha in tumor hypoxia, its genetics, regulation, and inhibition are discussed., Downregulation of HIF1A promoted cell death induction and prevented activation of cellular defense by hypoxia., Established cells overexpressing-HIF-1alpha, and these cells produce endothelin-1 mRNA., Suggest that HIF-1alpha induces VEGF/ET-1/iNOS during gastric ulcer healing., role in motility of erythroid progenitor cells in conjuction with autocrine motility factor, The high expression of HIF-1alpha in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension., A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF1A., Data supports the cyclooxygenase-2/prostaglandin E2/hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway possibly contributing to tumor angiogenesis in gastric carcinoma., Blocking HIF-1alpha degradation, either by saturation, or inhibition of prolyl hydroxylases or proteosomal degradation, leads to nuclear localisation of active HIF-1alpha proteins., under hypoxia, HIF-1alpha accumulates and transcriptionally activates its own degradation, The transient transfection of HIF-1 alpha cDNA induced U937 cells to develop the differentiation-related alterations such as growth arrest and increased CD11b expression., HIF-1alpha and CA IX, but not VEGF or MMP-9, may have a role in progression of surgically resected non-small cell lung cancer, reduction of oxygen consumption reduces the O2 gradient in conventional cell cultures, causing elevation of the cellular O2 concentration, which leads to degradation of HIF-alpha, pvon Hippel-Lindau tumor suppressor itself is induced in prolonged hypoxia in a kinetic that parallels the observed downregulation of HIF-1alpha protein under such conditions, Enhanced expression of HIF1A suppressed HIF2A and vice-versa., dysregulation of HIF-1alpha may induce the Warburg effect of aerobic glycolysis, The lack of a hypoxia-related difference in the expression of HIF-1alpha and its target genes suggests that HIF-1alpha does not play a critical role in high altitude adaptation, We therefore conclude that the alpha-MSH/cAMP pathway, using MITF as a signal transducer and HIF1alpha as a target, might contribute to melanoma progression., Results suggest an important role of stress-induced HIF-1alpha in the maintenance of chondrocyte viability in articular cartilage from osteoarthritis patients., In situ analyses showed that the tumours also have over-expression of hypoxia-inducible factor 1alpha (HIF1alpha) the hypothesis that increased succinate and/or fumarate causes stabilization of HIF1alpha a plausible mechanism, Data demonstrate that ARD1 has limited, if any, impact on the HIF-1alpha signaling pathway., Furthermore, we determined, for the first time, that EGCG inhibits prolyl hydroxylation of HIF-1alpha, thus preventing HIF-1alpha and pVHL interaction., Stat3 is required for both basal and growth signal-induced expression of HIF-1, The HIF-1alpha protein could up-regulate VEGF, resulting in angiogenesis of hemangioma., HIF-1alpha may have a role in preventing progression of early stage squamous cell carcinomas of the oral floor, Evidence of HIF-1 regulation of stanniocalcin-1(STC1) expression in human cancer cells. Implications as to role of STC1 in hypoxia induced adaptive responses in tumor cells., The review describes how activated T cells adapt to changing energy supplies in hypoxic areas of inflamed tissues by using hypoxia-inducible factor 1 (HIF1) to switch to glycolysis as the main source of energy., findings indicated that HIF1-alpha up-regulated expression of PDGF-B in human glioblastoma cells and showed the feasibility of siRNA technology in glioblastoma cell lines, This review presents a model incorporating HIF-1 alpha as an oxygen sensor which regulates oxygen homeostasis and stress responsive genes in chondrocytes, Results describe two degradation domains that differentially regulate the stability of HIF-1alpha., suggested that destabilization of HIF-1alpha by nitric oxide under hypoxia is under control of redox modulation; evidence provided that NO restores prolyl hydroxylase activity under hypoxia by affecting ROS production which lowers HIF-1alpha expression, HIF-1alpha may have a role in recurrence and survival in superficial bladder cancer, while Glut-1 may have a role in survival in invasive bladder cancer, Review of overall findings demonstrates the essential role of the hypoxia/von Hippel Lindau tumor suppressor/HIF-1 alpha pathway in endochondral bone development., HIF-1alpha expression in smooth muscle cells may augment vessel sprouting by loosening smooth muscle cell attachments to the basement membrane and endothelial cells, Accumulated EGLN1 in hypoxia acts as a negative-feedback mechanism to modulate HIF-1alpha target gene expression., egl nine homolog 1 can be considered as a candidate tumor suppressor on chromosome 1q, and our observation could open the new aspect in exploring the machinery of senescence induction associated with HIF-1 signal transduction, Coexpression of HIF-1alpha and CAIX in the epithelium in phyllodes tumors points to epithelial hypoxia, most probably caused by relatively distant blood vessels, HIF-1alpha accumulation and VEGF expression could be modulated by the antioxidant enzyme MnSOD., Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions., Polymorphism in the HIF1A gene may confer susceptibility to androgen-independent prostatic neoplasms., HIF protein levels were slightly induced by acidosis and inconsistent regulation of HIF target genes under acidosis suggest additional, yet unidentified pH-sensitive factors to be involved in the regulation of these genes., Hypoxia-inducible factor-1alpha (HIF-1alpha) is overexpressed in many human tumors and their metastases, and is closely associated with a more aggressive tumor phenotype., Unexpectedly, knockdown of HIF-1alpha induced parallel knockdown of Mcl-1 mRNA and protein expression, whereas Mcl-1 knockdown had no noticeable effect on HIF-1alpha expression. The action of HIF-1alpha appeared to be mediated in part via Mcl-1., Although the mRNA level of HIF-1alpha did not change much, the expression of its protein was significantly higher in nasal polyps than in inferior turbinate tissues., A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-2, Studies in human FaDu and HT 1080 tumor cells lines documented glucose requirement for hypoxia-induced HIF-1alpha protein accumulation, examination of binding with mutant forms of VHL proteins, The role of HIF-1alpha and HIF-2alpha on cell migration and proliferation in fibroblasts during hypoxia is reported., in pancreatic cancer cells, the p38-mediated phosphorylation of HIF-1alpha contributed to the inhibition of HIF-1alpha and von Hippel-Lindau tumor suppressor protein interaction during ischemia, androgen receptor is involved in VEGF and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer, HIF-1alpha and HIF-2alpha mRNA levels are transiently increased in untrained human skeletal muscle in response to an acute exercise bout, but this response is blunted after exercise training., We suggest, that, in addition to low oxygenation, insufficient supply of ascorbate or its excessive oxidation in tumors, can contribute to the induction of hypoxia-associated proteins via both HIF-dependent and independent mechanisms., ARD1 specifically binds HIF-1 alpha, suggesting a putative, still unclear, connection between these proteins., existence of an HIF-1alpha-bFGF amplification pathway that mediates survival and sprouting of endothelial cells under hypoxic conditions., Data suggest that a quadruplex structure may form in a region of the hypoxia inducible factor 1 alpha (HIF-1alpha) promoter that regulates basal HIF-1alpha expression., No mutations seem to occur in oxygen dependent degradation domain (ODD) of hif-1alpha in HIF-1alpha overexpressing invasive breast cancer, which rules ODD mutations out as possible explanation for diffuse HIF-1alpha expression pattern seen in this cancer, hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1alpha pathways, HIF1a has a role in determining sensitivity to inhibitors of mTOR in kidney cancer, Up-regulation of K(Ca) channels may be a novel mechanism by which HIFs can contribute to the malignant phenotype of human tumour cells., Coexpression of 2 VHL missense mutants (1 in the alpha domain & the other in the beta domain)restores HIF-mediated gene expression. VHL homotypic complexes target HIFalpha for ubiquitin-mediated proteolysis., Results indicate that normoxic stabilization of HIF-1alpha is a metabolic adaptation of nucleus pulposus cells to a unique oxygen-limited microenvironment, validating HIF-1alpha as a phenotypic marker of nucleus pulposus cells., Calpain plays an active role in degradation of HIF-1alpha., During hypoxia in A549 cells, HIF-1alpha promotes activity of the glycolysis pathway and decreases the pH of the culture medium, resulting in increased cellular apoptosis, MCT4, like other glycolytic enzymes, is up-regulated by hypoxia through a HIF-1alpha-mediated mechanism, Five antibody fragments bind within the functionally important oxygen-dependent degradation domain of the HIF-1alpha protein. Two of these antibody fragments were engineered into bivalent antibodies that were able to detect human HIF-1alpha., Under hypoxic conditions, the ANG and VEGF secreted by renal proximal tubular epithelial cells may modulate angiogenesis and vascular remodeling in the renal interstitium via an increase in the production of HIF-1, In aortic vascular smooth muscle cells from humans and Zucker rats cultured in normoxia insulin increases the HIF-1alpha content in cytosol and nucleus via dose- and time-dependent mechanisms., HIF-1alpha was strongly expressed in ovarian cancer and may upregulate the expression of VEGF increasing tumor growth and angiogenesis, These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms., These data demonstrate that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells., Lipopolysaccharide induces HIF-1alpha mRNA expression & HIF-1alpha accumulation in human monocytes & in non-differentiated & differentiated THP-1 cells under normoxia. With HIF-1 activation, increase in p44/42 MAPK phosphorylation was found with LPS., This study demonstrated that HDAIs repress both HIF-1alpha and HIF-2alpha transactivation potential independently of von Hippel-Lindau tumor suppressor and p53 function, and indicates that HDAIs may have biological effects in a broad range of tissues., Normal amounts of BRCA1 function in hypoxia to regulate HIF-1alpha stability, probably by interacting with HIF-1alpha, leading to reduced levels of VEGF., there is an alternative mechanism for the hypoxic induction of VEGF in colon cancer that does not depend upon HIF-1alpha but instead requires the activation of PI3K/Rho/ROCK and c-Myc, The expression level of HIF-1alpha mRNA is surmised to have a significant correlation with tumor angiogenesis, cell proliferation, apoptosis, and metastasis of pancreatic cancer., In hypoxia, HIF-alpha is stabilized and either dimerizes with HIF-beta to form transcriptionally active HIF for a hypoxia response, or it interacts with unrelated proteins, enabling convergence of HIF oxygen sensing with other signaling pathways., High expression of HIF-1alpha and VEGF-C is associated with lymphangiogenesis and invasiveness in breast cancer, Zn chelation causes the accumulation of nonfunctional HIF-1alpha protein in both normoxia and hypoxia., Expression correlates with advanced disease stage, increased angiogenesis and poor prognosis in human glioma., Data show that during placental development, HIF1A is regulated by temporal and spatial changes in expression and association of molecules forming the multi-protein von Hippel-Lindau tumor suppressor complex as well as prolyl hydroxylase activities., VEGF and HIF-1alpha are elevated in malignant gliomas. HIF-1alpha inhibition results in VEGF secretion inhibition. HIF-1alpha expression affects glioma tumor growth, suggesting clinical applications for malignant glioma treatment., placental sFlt-1 expression is increased by both physiologically and pathologically low levels of oxygen mediated via the transcription factor HIF-1, Expression of VEGF and Ang-2 correlated with microvessel density. Strong Ang-2 expression and/or high nuclear expression of HIF-1alpha is a significant predictive factor for recurrence after curative resection in hepatocellular carcinoma patients., scavenging of nitric oxide by reactive oxygen species and vice versa attenuate HIF-1alpha accumulation in a concentration-dependent manner, HIF-1alpha function might be therapeutically targeted by inhibition of the PI 3-kinase/Akt pathway, HIF-1alpha may play a crucial role for the survival of disc cells and resorption of the herniated disc in human intervertebral discs., ERK5 and ERK1/2 differ in their mechanisms of gene regulation, and ERK5 may control hypoxia-responsive genes by a mechanism independent of HIF-1alpha expression control, With the scar maturation, the expression of HIF-1alpha gradually decreased while the expression of p53 gradually increased., differential compartmentalization of degradation of HIF-1 alpha and the subcellular distribution of HIF-1 alpha may account for cell-type-specific differences in stabilizing HIF-1 alpha protein levels under hypoxic conditions, lower levels of HIF-1alpha in the lymph node metastases, probably induced by the less hypoxic environment, further lowered CXCR4 levels., hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment are regulated in a cell-specific manner, The regulation of HIF by VHL plays a major role in calibration and homeostasis of the respiratory and cardiovascular systems., A homozygotic mutation in the von Hippel-Lindau gene that results in upregulation of hypoxia inducible factor 1alpha (HIF-1alpha) under normoxic conditions., HIF-3alpha, as a member of the HIF system, is complementary rather than redundant to HIF-1alpha induction in protection against hypoxic damage in alveolar epithelial cells., p110alpha and AKT1 play an important role in tumor growth by inducing angiogenesis and by increasing HIF-1alpha expression. This work provides a better understanding of the molecular mechanism of human cancer induced by the activation of PI3K signaling., A significantly greater proportion of HP75 cells transfected with siRNA targeting HIF 1-alpha mRNA sequences and exposed to hypoxia demonstrated apoptosis to a large extent when compared with non-transfected cells., a novel mechanism by which a growth factor controls hypoxia-inducible transcription factor-1 (HIF-1alpha) stability, and thereby drives the expression of specific genes, through the regulation of HIF-1alpha-associated prolyl hydroxylase (PHD2) levels, Involvement of HIF-1 in uveal melanoma tumorigenesis is significant and metabolic regulation of HIF-1 activation in Mum2B uveal melanoma cells has its specificities., High HIF-1alpha expression is associated with head and neck cancer, visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region., HIF-1alpha polymorphisms may have an important impact on HIF-protein stability and function, Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells., The phosphoinositide 3-kinase (PI3K)/Akt pathway is commonly activated in cancer; therefore, we investigated its role in hypoxia-inducible factor-1alpha (HIF-1alpha) regulation., HIF-1alpha is a potent and rapid inducer of migration inhibitory factor expression., HIF-1alpha polymorpisms are an important factor for development of a subset of ulcerative intestinal tumors, Allele C and genotypes containing this allele were associated with a higher risk of stroke in the Moscow population., The latency-associated nuclear antigen (LANA) directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha)., Western blot analysis revealed that 2-oxoglutarate dose-dependently inhibited the HIF-1alpha protein level in Hep3B cells in hypoxic conditions., HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors, This hypothesis indicates a possible novel function of heparanase and its link to HIF1alpha and Cox-2, and therefore this function would give us a clue about potential new strategies for cancer therapy., The HIF-1alpha immunopositivity increased through the tumor development with highest expression in the late nodular stages., HIF-1alpha expression in patients with breast cancer is a marker of poor therapy response and outcome, especially in ER-positive patients., Pseudomonas aeruginosa can recognize and respond to extracellular end products of intestinal hypoxia that are released after activation of HIF-1alpha., HIF-1alpha may represent an important target molecule for rrenal cell carcinoma therapy, but HIF-2alpha should be targeted in HIF-1alpha defective renal cancer cells., Over-expression of iNOS and HIF-1alpha in colorectal carcinoma is correlated with the biological character microvessel density., A rationale for targeting HIF-1 alpha with histone dacetylase inhibitors against class II isozymes as anticancer agents., The HIF-1alpha is considered to be a useful independent prognostic factor in gastric cancer, and the combination of a HIF-1alpha protein overexpression with nonfunctional p53 tends to indicate a dismal prognosis., phosphorylation of Ser-641/643 by mitogen-activated protein kinase promotes the nuclear accumulation and transcriptional activity of HIF-1alpha by blocking its CRM1-dependent nuclear export, MTA1 enhances angiogenesis by stabilization of the HIF-1alpha protein, which is closely related to the increased metastatic potential of cancer cells with high MTA1 expression, visfatin mRNA expression is upregulated in the fat tissue of obesity through the activation of HIF1alpha pathway due to hypoxia, This study failed to demonstrate any prognostic significance of COX-2 expression alone or co-expression with HIF-1alpha or VEGF in advanced NPC., Homozygous HIF-1 alpha Pro582Ser mutation confers significant susceptibility to prostate cancer., demonstrated that the von Hippel-Lindau-mediated protein destruction motif of HIF-1alpha endowed procaspase-3 with hypoxia-specific cytotoxicity, HIF-1alpha is induced by cobalt in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism, importance of IL-1beta-induced HIF-1alpha in regulation blood-brain barrier permeability and angiogenesis, Hif-1alpha plays a key role in conferring apoptosis resistance under hypoxia., Differential expression of p-ERK, p-PKB and HIF-1alpha may be involved in the occurrence of hypoxia-induced pulmonary hypertension in COPD patients., This study highlights the importance of p38 MAPK and HIF-1 in hypoxia-mediated proliferation of pulmonary artery adventitial fibroblasts., PHD2 induction is an underlying mechanism of NO-induced degradation of HIF-1alpha, VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail, HIF-1alpha expression is related to the resistance of tumor cells to chemo- and radio-therapy., Immunophilin-ligands FK506 and CsA suppress HIF1alpha expression by accelerating the proteasomal degradation of the protein; the suppressive effect is independent of the presence of von Hippel Lindau factor and the degree of hydroxylation of HIF1alpha., CXCR4 was consistently found colocalized with HIF-1alpha expression in pseudopalisading glioma cells around areas of necrosis., Transcriptional coordination of adenosine a2B receptor by HIF-1alpha and amplified adenosine signaling during hypoxia., Results describe the differential recruitment of HIF-1alpha and HIF-2alpha to common target genes in neuroblastoma, and show that HIF-2alpha promotes an aggressive phenotype., IL-4 induced up-regulation of HIF-1alpha gene transcription and the PI3K signaling pathway, MUC1 attenuates HIF-1alpha activation in a survival response to hypoxic stress, histone deacetylase inhibitors inhibit HIF activity by destabilizing HIFnd repressing its transactivation potential [review], activity of the alpha-subunit of the hypoxia-inducible transcription factor (HIF-alpha) are regulated by its post-translation hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl hydroxylases (PHD1-3)., PFKFB-4 and PFKFB-3 genes are expressed in gastric and pancreatic cancer cells, they strongly respond to hypoxia via a HIF-1alpha dependent mechanism and possibly have a significant role in the Warburg effect which is found in malignant cells, The results suggest HIF-1alpha is involved in gastric carcinogenesis and disease progression, but is only a weak prognostic factor for survival., HIF-1alpha gene expression was constant during early pulmonary organogenesis., P53 was highly expressed in the placenta of pregnant women with intrahepatic cholestasis of pregnancy (P < 0.01), however the HIF-1alpha expression was not up to higher than in normal control., Overexpression of HIF-1alpha is associated with breast carcinomas, Hypoxia increases and activates myocardial HIF-1 which mediates the induction of VEGF,eNOS,p38MAP kinase and this may play a role in neovascularization,abnormal vessel formation, and cardiac remodeling., These results reveal that, although pericellular hypoxia may be a major contributor to HIF-1 activity, changes in the levels of soluble factors may also play a role. This study demonstrates that HIF-1 is required for CDR., HIF-1alpha is inhibited by NSC 644221 in a process that is topoisomerase II-dependent, Hypoxia-inducing factor-1alpha is overexpressed in the intima of middle cerebral artery of Moyamoya patients., variations in HIF1alpha may play an important role in the pathogenesis and risk factor for osteonecrosis of the femoral head, The upregulated expression of HIF-1alpha and VEGF in breast carcinoma has a close relationship with tumor angiogenesis, tumor cell proliferation, lymph node metastasis, ER status and stages of histology., These results demonstrate that hypoxic condition-and high cell density-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway., HIF-1a is a key factor responsible for angiogenesis by the induction of VEGF in a human osteosarcoma cell line., hypoxia-inducible factor-1 alpha is modulated in cultured primary cells by intracellular ascorbate, direct regulation of HIF-1alpha stability by Glycogen synthase kinase 3 may influence physiological processes or pathophysiological situations such as metabolic diseases or tumors, We conclude that HIF-1alpha overexpression enhances lung cancer cell invasion at least through up-regulating the expression and activities of uPAR, MMP1, and MMP2., Hemin induces a serum protein-sensitive pro-inflammatory phenotype in microvascular endothelial cells via an oxidant-sensitive mechanism that is powerfully regulated by HIF-1., induction of HIF-1alpha by atherogenic factors may be a key step in coordinating the cellular events that result in atherosclerotic lesions, Carbon monoxide conditions the macrophages via a HIF-1alpha and TGF-beta-dependent mechanism and the earliest events in macrophage signaling that lead to and preserve cellular homeostasis at the site of injury., HBx and HIF-1alpha were widely expressed in hepatocellular carcinoma tissues and there is a positive relationship between them., DEC1 downregulates hypoxia-inducible factor 1alpha at both mRNA and protein levels at hypoxia in lung adenocarcinoma cells, Repeated exposure to chromium can lead to extended stabilization of HIF-1alpha emphasize the important role of ascorbate in regulation of HIF-1 transcriptional activity in metal-exposed human lung cells., Asparagine hydroxylation and S-nitrosylation of HIF-1alpha decrease p300 binding, while its phosphorylation does not affect p300 binding, which was reconfirmed by competitive inhibition analyses using mutant peptides., comparison of the expression of HIF-1alpha and GLUT-1 with various clinicopathological features of colorectal cancer, broad impact of the HIF-1 transcription factor on gene expression could make it a key regulator of UV-responsive genes and photocarcinogenesis., Hif-1 alpha, which is related to tissue hypoxia in endometrial cancer, is associated with overexpression of Ob and ObR (leptin and leptin receptor)., Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation., In conclusion, we provide the molecular mechanism of the cross talk between HIF-1alpha and Id-1, which may play a critical role in tumor angiogenesis., These results indicated that in prostate cancers, HIF-1 might cooperate with the AR to activate the expression of several genes related to tumor angiogenesis, invasion, and progression., Immunohistochemical expression of hypoxia-inducible factor (HIF)-1alpha in Barrett's esophagus metaplasia-dysplasia-adenocarcinoma sequence.i, transient RNAinterference directed against HIF-1alpha can effectively curb glioma growth in vivo., We found that BPQ did not inhibit HIF-1alpha mRNA level, but inhibited its protein expression in a proteasome-dependent manner., During trophoblast hypoxia glucose transporters (GLUT1/3) are upregulated via HIF-1 alpha pathway., HIF-1alpha expression has no correlation with GST-pi expression in hypoxic lung adenocarcinoma cells., Here, we investigated the regulatory mechanism of HIF-1alpha expression by LPS in hepatocytes and identified that LPS-induced HIF-1alpha mediate gene transcription of a typical inflammatory mediator, tumor-necrosis factor alpha (TNFalpha)., The role of protein expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1) in patients with colorectal adenocarcinomas., Prostate tumor cells selected by hypoxia, normoxia or hyperoxia utilize HIF-1alpha in different ways to allow cell survival/growth., HIF-1alpha may induce the angiogenesis in gastric carcinoma by upregulating the transcription of VEGF gene, and take part in tumor invasion and metastasis. They can be used as prognostic markers of gastric cancer in clinical practice., sustained expression of HIF-1alpha can inhibit cell hyperplasia, and the apoptosis promotion of injured cells as well as provide protection of endothelial cells, HIF-1alpha is involved in transcriptional induction of inflammatory chemokines monocyte chemoattractant protein (MCP)-1 and MCP-5 in hypoxia-stimulated astrocytes., There may be a hormonal and hypoxia-independent regulatory mechanism coordinating the expression of HIF-1alpha, HIV-2alpha, VEGF, the androgen receptor, and FOXP1 in prostate tumors., hypoxia-inducible factor 1 negatively regulates mitochondrial biogenesis and O(2) consumption in renal carcinoma cells lacking the von Hippel-Lindau tumor suppressor, over-expression of HIF-1alpha may play an important role in pancreatic ductal adenocarcinoma progression, HIF-1A mRNA is reduced in abundance in response to hypoxia., Data show that Chlamydia pneumoniae directly interferes with host cell HIF-1alpha regulation in a biphasic manner., Major oxygen-dependent HIF isoforms are strongly upregulated in psoriatic skin with HIF-1alpha mainly in the epidermis, in an expression pattern similar to VEGF mRNA., HIF-alpha proteins and regulated genes are not increased in placentas from normotensive pregnant women delivering small, asymmetrically grown babies, shows for the first time HIF-1alpha is causally linked to the protective effects of ischemic preconditioning on endothelial cells., Potassium chloride may act through the calcium-independent pathway leading to enhanced HIF-1A transcriptional activity in gastric cancer cells., Erythropoietin may protect the kidneys against ischemia reperfusion injury by activating HIF-1alpha., Data show that human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.(, HIF-1alpha expression levels were significantly higher in ovarian clear cell carcinoma than in other histological types., In papillary thyroid carcinoma, HIF-1 alpha, VEGF and VEGF-C expressions are significantly increased., Reduction of HIF1alpha levels using antimycin-A or siRNA targeting HIF1alpha did not affect PKB/Akt activation in hypoxia., HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis., nuclear expression of HIF-1alpha was significantly higher in stage III and IV ovarian tumors than stages I and II; cytoplasmic expression of HIF-1alpha did not show differences among histological malignancies, SSAT2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha, hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha in prostate cancer has been confirmed and also immunoreactive HIF-1alpha and downstream gene products were identified in benign and malignant prostate neuroendocrine cells, These findings provide genetic evidence that hypoxia utilizes mitochondrial reactive oxygen species as signaling molecules to activate HIF-dependent extension of replicative life span., Eradication of HIF-1-active/hypoxic cells in the xenografts during irradiation exhibited significant suppression in angiogenesis and strong enhancement in a long-term growth suppression of tumor xenografts., The hypoxia-inducible factor is stabilized in circulating hematopoietic stem cells under normoxic conditions., both HIF-1alpha and HIF-2alpha play important and similar roles in hypoxia-mediated stimulation of PAI-1 expression in HTR-8/SVneo cells, Overexpression of obesity hormone leptin and its receptor in human colorectal cancer appears to be associated with the abundance of hypoxia-inducible factor (HIF)-1 alpha., gal-3 is a HIF-1-regulated lectin that plays an important role in nucleus pulposus cell survival., Statistically analyzed distributions of the proteins reflected functional dependences among STAT3, HIF-1alpha, EPO and EPOR in cellular signal conduction., hypoxia-inducible factor 1 alpha (HIF-1alpha) alpha expression is upregulated in activated macrophages under normoxic conditions and in inflammatory atherosclerotic plaque, HIF-1alpha demonstrates the potential to be a predictive marker for PGD, Polymorphisms in the HIF-1alpha are not directly associated with prostate neoplasms., LANA can function not only as an inhibitor of HIF-1alpha suppressor proteins but can also induce nuclear accumulation of HIF-1alpha during KSHV latent infection., The role of HIF-1alpha protein through its nontranscriptional activity in myeloid cell differentiation., Increased expression of HIF-1alpha may be involved in sinusoidal capillarization and the increased numbers of unpaired arteries in capillarized areas with increased numbers of unpaired arteries in dysplastic liver nodules., The HIF-1alpha and iNOS expression index of cholesteatoma epithelium was significantly higher than that of external ear canal normal skin., Leptin's gene expression regulation in breast cancer is dependent on HIF-1alpha., PKA was shown to be involved in the phosphorylation of HIF-lalpha under intermittent hypoxia, while p42/p44 and Akt were not., the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia., The HIF-1alpha pathway is activated in response to subepithelial remodeling and contributes to progressive premalignant epithelial lesions in the airways of tobacco smokers with chronic airway inflammation., bFGF augments hypoxia induced VEGF release in breast cancer cells mainly through the PI3K pathway and partly depending on HIF-1 activity., HIF-1alpha increased DNA-binding ability and transcriptional activity of Runx1 protein., KBP reduces expression of VEGF and HIF-1alpha nuclear translocation, Under hypoxic conditions, HIF-1alpha and HIF-2alpha proteins are not transcriptionally regulated at the mRNA level but are probably regulated at the post-mRNA level., CREB binding to the HIF-1 responsive elements in PAI-1 promoter mediates the glucagon effect in the liver, Substrate specificity of HIF1alpha subunit prolyl-4 hydroxylase HIF1 alpha subunit is determined by a region relatively remote from the catalytic site of the enzyme., Prolyl 4-hydroxylases (P4Hs) act on collagens (C-P4Hs) and the oxygen-dependent degradation domains (ODDDs) of hypoxia-inducible factor alpha subunits (HIF-P4Hs) leading to degradation of the latter., HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2 and pyruvate dehydrogenase kinase 1., HIF-1alpha was closely linked to an aggressive phenotype in breast cancer., BNP is a specific HIF-1alpha target gene, We thus propose that NDN regulates neuronal function and hypoxic response by regulating the activities of the ARNT2, Transactivates SAG (sensitive to apoptosis gene) in response to hypoxia., ING4 suppression in MM cells up-regulated IL-8 and OPN, increasing the HIF-1alpha activity and its target gene NIP-3 expression in hypoxic condition, high levels of the hypoxia regulated proteins HIF1alpha and CA9 in HNC predict resistance to platinum based radio-chemotherapy., SSAT1, which shares 46% amino acid identity with SSAT2, also binds to HIF-1alpha and promotes its ubiquitination/degradation. However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1, conclude that the loss of iron-regulatory syste is not the course of erythrocytosis, We conclude that edaravone inhibits VEGF expression in astrocytes exposed to hypoxia, at least partly, through the down-regulation of HIF-1alpha., Both the ERK pathway and the PI3K pathway are involved in the cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts and in the expression of proangiogenic factors, provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the phosphatidylinositol 3-kinase/AKT pathway and activation of NFkappaB, HIF-1 activity does not require rapid proteolytic turnover of the vascular endothelial growth factor promoter-bound transactivator, nor is the activator-promoter complex constantly disassembled by chaperones, Levels of IAP-2 and Bax were decreased in A375 cells and HIF-1alpha was increased during hypoxia., HIF-1 activity is necessary and sufficient for the mobilization of angiogenic cells; HIF-1alpha transgene therapy counteracts the pathological effects of aging in a transgenic mouse model of limb ischemia., These findings identify novel and intricate signaling mechanisms involved in HIF-1 complex activation and will lead to the elucidation of the importance of HIF-1 in different Angiopoietin II-related cell responses., HIF-1 may be involved in angiogenesis by controlling expression of VEGF in vivo. Possible strategy for treatment of angiogenesis by targeting HIF-1 alpha in ischemic retinopathies., RSUME is induced by hypoxia and enhances the sumoylation of HIF-1alpha, promoting its stabilization and transcriptional activity during hypoxia., that intracellular calcium levels can regulate HIF-1alpha expression by modulating calcineurin activity and RACK1 dimerization., differences in reactive oxygen species production, HIF proliferation, and cell proliferation contribute to the differences in tumor phenotype in cells lacking SdhB as opposed to those lacking SdhA, HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2), identify a novel nuclear export motif, further highlight the role of nuclear-cytoplasmic shuttling of E3 ligases in degradation of nuclear substrates, and provide evidence that disease-causing mutations can target subcellular trafficking, Inhibitory effect of 6-formylpterin on HIF1A protein accumulation is reported., These findings demonstrate that HIF-1alpha function is negatively affected by its interaction with MgcRacGAP., hypoxia-independent promotion of the AKT-HIF-1alpha-VEGF pathway contributes, at least in part, to gastric cancer tumorigenesis and angiogenesis, An oxidative signal as a result of NO/O(2)(-) coformation triggers a calcium increase that activates calpain to degrade HIF-1alpha, independently of the proteasome., Review of HIFalpha proteins demonstrates that distinct prolyl hydroxylase domain proteins, including HIFalpha proteins, are remote from the catalytic site and function in substrate discrimination., differential expression of prolidase in 2 breast cancer cell lines showed prolidase-dependent differences in HIF-1 alpha levels, HIF-1 alpha polymorphisms may have a significant influence on the poor prognosis of the patients undergoing radical cystectomy for bladder cancer, while they seem to have no relation to the bladder cancer occurrence, The neurohormone orexin stimulates HIF-1 activity., HIF-1alpha may be an immunohistochemical marker for vasculitic neuropathy, CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction, HIF-1 and HIF-2 are detected in the endothelium and macrophages. Hypoxia-inducible factors in endothelial cells may induce VEGF, thereby contributing to the development of choroid neovascularization., VEGF, HIF-1alpha and CD34 expressions were more common in gastric tumors without serosal invasion, In BRCA1 germline mutation related breast cancer, functional HIF-1alpha overexpression is seen at a much higher frequency than in sporadic breast cancer., HIF-1 alpha is expected to be useful for detection of the viability of PAs after NHT and also for prediction of their clinical outcome, Polymorphisms in HIF1A were associated with development of stable exertional angina rather than acute MI as the initial clinical presentation of CAD., HIF-1alpha signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes, PG activates HIF-1 and enhances the resultant gene expression by directly affecting the intracellular oxygen sensing system in vitro and in vivo, Transcription factor HIF-1alpha is involved in the up-regulation of mPGES-1 and may therefore play an important role in the metabolism of osteoarthritic cartilage., extracellular matrix genes are induced in dermal fibroblasts by HIF-1alpha-dependent, as well as HIF-1alpha-independent, mechanisms, HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells, Hydrocamptothecin could inhibit the expression of HIF-1alpha protein and downstream VEGF gene in hypoxic SiHa cells in a dose-dependent manner., HIF-1alpha and COX-2 could upregulate each other to promote the development and metastasis of laryngeal squamous carcinoma., We have identified a new three-gene classifier that is independent of and improves on stage to stratify early-stage NSCLC patients with significantly different prognoses., To our knowledge, this is the first report of differing HIF-1 activation between two strains of animals with clearly divergent physiological responses to identical hypoxic conditions., mitochondrial abnormalities that disturb the reactive O(2) species HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of pulmonary arterial hypertension and cancer--REVIEW, HIF-1 alpha is an important independent prognostic factor for patients with metastatic clear cell RCC, GLUT-1 overexpression is to some extent regulated by HIF-1alpha and is also strongly associated with histological features, expression is an early event in oral carcinogenesis, Studies using loss and gain of function of HIF-1 confirmed a critical role of HIF-1alpha in coordinating TLR2 and TLR6 induction, findings support the hypothesis that the HIF-1Alpha P582S variant may confer susceptibility to subgroups of breast cancer in Korean women, There was a significant correlation between nuclear BNIP3 expression and HIF-1alpha expression and HIF-2alpha expression but no correlation between BNIP3 and pre-operative PSA, tumor volume, margin positivity or capsular invasion., These results imply that HIF-1alpha functions as an up-stream player in the p21-mediated growth arrest of keratinocytes., mitochondria has an essential role in HIF-1 regulation, These data suggest that HIF-1 activation of HREs within the putative chk-a promoter region can increase Chk-A expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments., The protein expression of Hypoxia-Inducible Factor 1 was observed in 9 of 11 cases of cancer tissues., Methylation analysis of 3' enhancer showed that it was free of methylation in 70% cells in A2780, while in less than 16% in both TC1 and HeLa cells, thereby suggesting that TUBB3 increase upon hypoxia is abolished through methylation of the 3' enhancer., the HIF-1alpha pathway is a critical mediator of neoangiogenesis required for skeletal regeneration, We describe a family with erythrocytosis and a mutation in the HIF2A gene, which encodes the HIF-2alpha protein. this mutation leads to stabilization of the HIF-2alpha protein and suggest that wild-type HIF-2alpha regulates erythropoietin production, Data show that lipopolysaccharides induce HIF-1alpha activation by enhancing both protein expression and transcriptional activity in differentiated THP-1 human myeloid cells but not in undifferentiated cells., This study suggests that NDRG2 is a Hif-1 target gene and closely related with hypoxia-induced apoptosis in A549 cells., may play a role in malignant transformation of oral submucous fibrosis, Accumulation of HIF-alpha proteins in preeclampsia placentas may occur as a consequence of both increased formation secondary to relative ischemia/hypoxia and reduced degradation after reperfusion/oxygenation consequent to proteasomal dysfunction., Hypoxia-induced increase in the level of HIF-1alpha in retinal pigment epithelium can be an important step in choriodal neovascularization., Activation of the thyroid hormone receptor beta/retinoid X receptor alpha heterodimer by T(3) stimulated expression of the hepatic leukemia factor, which increases HIF-1alpha gene expression., Insight into its applicability for pharmacologic targeting of HIF-1alpha for cancer therapeutic or chemopreventive purposes prostatic cancer., The high expression of HPA mRNA and HIF-1alpha protein is correlated with carcinogenesis, progression, invasion and metastasis of esophageal squamous cell carcinoma., HIF-1alpha may protect the hepatocellular carcinoma cells from damages by radiation in hypoxic condition, possibly by inducing VEGF expression., Hypoxic preconditioning of cisplatin-treated proximal tubular cells in culture reduced apoptosis in an HIF-1alpha-dependent fashion., AMP kinase is a key determinant of HIF-1 functions in response to reactive oxygen species and may be involffed in HIF-1 regulatory mechanisms., is the first case-control study that investigates the association of HIF-1alpha polymorphisms with sporadic breast cancer in the Turkish population, A role for HIF1A as an endogenous marker of tumor hypoxia is currently not supported by the available clinical data., Under hypoxic conditions an autocrine loop between VEGF-C/VEGFR-3 and HIF-1 alpha is possible in breast carcinoma and lung carcinoma but not in colorectal carcinoma cell lines., These results imply that Pin1 stimulates VEGF expression by activating HIF-1alpha and AP-1, and suggest that Pin1 is a potential therapeutic target of angiogenesis during cancer development., These results suggest that MT-III upregulates VEGF production in brain endothelial cells by a HIF-1alpha-dependent mechanism., a key signalling pathway involving HIF-1alpha and TWIST promotes metastasis in response to intratumoural hypoxia, Notch ICD enhances recruitment of HIF-1alpha to its target promoters and derepresses HIF-1alpha function, Under hypoxic conditions, HIF-1 alpha-specific shRNA effectively silences HIF-1 alpha, and consequently down-regulates VEGF expression., HIF-1 alpha-specific siRNA could decrease HIF-1 alpha expression under both normoxia and hypoxia conditions, but VEGF expression was downregulated under hypoxic conditions only., role for HIF-1alpha in transcriptional repression of adenosine kinase in hypoxia, These findings strengthen the importance of the role of PARP1 as a transcriptional coactivator of HIF-1-dependent gene expression during tumor progression., Genistein significantly inhibited the expression of HIF-1alpha protein induced by CoCl(2) in dose-dependent manner., Suggest role for bacterial siderophores in hypoxia-independent activation of HIF-1 during infection with human pathogenic bacteria., Hypoxia and epidermal growth factor receptor signal coexisted in the tumor microenvironment and might promote angiogenesis through HIF-1 alpha-mediated upregulation of SCF and other angiogenic factors., HIF1A has a crucial role in regulating extravillous trophoblast behavior including matrigel-induced endovascular differentiation under normoxia., Chronic hypoxia not only increases the pool of PHDs but also overactivates the three PHD isoforms., Upregulation of HIF-1 alpha and its downstream targets GLUT1 and SDF-1 in colorectal adenomas and carcinomas may be due to hypoxia., HIF-1alpha and hypoxia play a crucial role for dendritic cell activation in inflammatory states, HIF-1alpha expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma, HIF-1alpha may play an important role in colon cancer angiogenesis, In endometrial cancers, no mutations of prolines P402 and P564 were found within the HIF-1alpha oxygen-dependent degradation domain., TXNIP is induced in response to hypoxia in a HIF-1alpha-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy., Cyr61 promoted gastric cancer cell invasive ability via an HIF-1alpha-dependent up-regulation of PAI-1., The downregulation of ETS1 expression with small interfering RNA (siRNA) involves HIF1alpha in regulating hypoxia-inducible genes., These results suggest that the hypoxia induces the migration of coronary artery smooth muscle cells, and that the migration is elicited by TSP-1 of which induction is fully dependent on the stabilization of HIF-1alpha, in autocrine regulation., Crocidolite, dexrazoxane and hypoxia induce doxorubicin resistance in human malignant mesothelioma cells by increasing hypoxia-inducible factor-1alpha activity, direct modulation of HIF-1alpha expression by nuclear factor kappaB, PlGF-induced expression of ET-1 and its cognate ET-BR receptor occur via activation of HIF-1 alpha, independent of hypoxia., Overexpression of MnSOD in breast epithelial cells alters stabilization of HIF-1 alpha under hypoxic conditions., coronary artery disease patients had higher expression of HIF-1alpha (Hypoxia-inducible factor-1alpha) ;higher HIF-1alpha expression was observed in patients with collaterals compared with patients with no collaterals, Glut1 and HIF-1 alpha are highly expressed in non-small cell lung carcinoma, and their expressions are associated with tumor differentiation and clinical stage., Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer., COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination, inflammatory levels of NO inhibit epithelial cell migration, because of suppression of ERK1/2 signaling, and activation of HIF-1alpha and p53, with potential consequences for epithelial repair and remodeling during airway inflammation, Nitric oxide donor, (+/-)-S-nitroso-N- acetylpenicillamine, stabilizes transactive HIF1-alpha by inhibiting VHL and asparagine hydroxylation., Constitutive activation of the HIF-1alpha C-transactivation domain , and not merely stabilization of the HIF-1alpha molecule, is essential for optimal HIF-mediated transcriptional and angiogenic effects., HIF-1alpha is an important component of the apoptotic signaling machinery in cardiomyocytes and renal epithelial cells., might be markers of depth of invasion or lymph node involvement. HIF-1alpha expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers, HIF-1alpha accumulation is able to increase level and activity of HMG-CoAR by stimulating its transcription, HIF-1alpha protein is selectively required for down-regulation of ASK1 activated during lipopolysaccharide-induced TLR4 downstream signalling., In hepatitis B-related hepatocellular carcinoma,HIF-1alpha expression was found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein expression in vitro, TPO induces HIF-1alpha expression in a manner very similar to that of hypoxia., The expression of hypoxia-induced VEGF mRNA increased with the increased expression of HIF-1 alpha mRNA in the cell lines tested at the initial stage of hypoxia., The high expression of HIF-1alpha and BNIP3 were closely related in laryngeal carcinomas., The present study suggested that the expression level of HIF-1alpha could be an independent prognostic factor in epithelial ovarian cancer., Antizyme suppression leads to an increment of the cellular redox potential and an induction of HIF-1alpha, functional interdependence between MIF and HIF-1alpha protein stabilization and transactivation activity provide a molecular mechanism for promotion of tumorigenesis by MIF, Age-dependent loss of HIF-1alpha expression and impaired wound healing in diabetic mice was corrected using electroporation of human HIF-1alpha., HIF-1alpha expression was shown to have no significance on survival, Our data suggest increased HIF-1alpha expression is an important marker for metastases in osteosarcoma patients., The expression of HIF-1alpha was significantly higher in nasopharyngeal carcinoma and in the lymph node metastasis group than in the no-metastasis group., There was significant difference in distribution of HIF1alpha allele frequencies between Chinese Hans and Caucasians., Results report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L., HIF-1alpha was overexpressed in OSJ. HIF-1alpha expression was correlated with tumoral microvascular density, with size, pathologic grade, and clinical stage of OSJ. Expression of HIF-1alpha was also correlated with clinicopathologic characteristics., HIF-1alpha target provides a new sight into the mechanisms of sulforaphane's inhibition against tumor cell proliferation, AQP1 and HIF1 interact each other and regulate the oncogenesis of breast cancer, Prostate cancer cells counteract the stress of prolonged serum deprivation by upregulating HIF-1 alpha protein which increases IGF-2 expression to promote cell survival., Inhibition of HIF-1alpha could effectively down-regulate the expression of MMP-2 in human cervical carcinoma Hela cells., PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha., HIF-1alpha can regulate MMP1 and MMP3 expressions in human bmMSCs, which might suggest a pathophysiological role of bmMSC expressing high HIF-1alpha in bone diseases., Measuring PDGFA, bFGF, and HIF1a expression may contribute to a better understanding of the prognosis of patients with pancreatic cancer., HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells., Nasal epithelial cells actively produce HIF-1alpha and VEGF when stimulated by LPS, IL-1beta or hypoxia., study concludes that IFN-alpha induces the transcription of HIF-1alpha in human endothelial cells though a JAK-ISGF3 pathway under normoxic conditions, and that this response contributes to the antiproliferative activity of this cytokine, Hypoxia-inducible factor-1alpha knockdown abolishes hypoxia-induced apelin expression., Hypoxia-inducible factor-1alpha overexpression alone, has no impact on the prognosis of colorectal carcinomas., HIF-1alpha is elevated in both TM and GBM, suggesting that although hypoxia is one of the most powerful stimuli for HIF-1alpha elevation and consequently angiogenesis, other mechanisms may cause HIF-1alpha increase in brain tumors such as TM., HIF-1alpha might play a crucial role in regional lymph node metastasis as a regulator of lymphangiogenesis and angiogenesis in OSCC with a possible novel pathway involving VEGF-C., a circuit involving c-myc, miR-17-92, and HIF-1 alpha may play a role in cancer cell proliferation under normoxia in a cellular context-dependent manner, accumulation of HIF-1alpha in activated mast cells requires up-regulation of HIF1A gene transcription and depends on the calcineurin-NFAT signaling pathway, These findings show a novel mode by which HIF-1alpha is regulated not only in cancer cells but also in the tumor-associated inflammatory cells, suggesting Stat3 as an important molecular target for inhibiting the oncogenic potential of HIF-1., In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression, Quercetin suppressed the HIF-1alpha accumulation during hypoxia in human cancer cell lines and reduced hypoxia-induced secretion of VEGF, Report transcriptional activation of HIF-1 by RORalpha and discuss its role in hypoxia signaling., Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK., analysis of of degradation of HIF-1alpha at normoxia that involves pVHL but is not mediated by PHDs 1-3 or by degradation boxes surrounding Pro(402) and Pro(563), The transcriptional activation of HIF-1 induced by hypoxia or DFO was visualized by both bioluminescence and scintigraphic reporter gene systems., HIF-1 alpha and Survivin are mostly expressed in invasive CRCs. Inhibition of HIF-1 alpha may lead to exploration of its potential as a diagnostic tool and possibly a target for gene therapy for colorectal carcinoma., Results show that many genes regulated by hypoxia and HIF-1alpha show patterns of induction with JMJD (Jumonji-domain containing)1A and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia., Results suggest that HIF1 contributes to keratinocyte migration and thus to the re-epithelialisation process by regulating laminin-332., increased PDK3 expression due to elevated HIF-1alpha in cancer cells may play critical roles in metabolic switch during cancer progression and chemoresistance in cancer therapy, Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene., High expressions of HIF-1alpha and Ang-2 proteins in laryngeal squamous cell carcinoma may play an important role in tumor growth, invasion and metastasis., HIF-1 alpha, a protein rapidly responsive to all-trans retinoic acid, plays a role in all-trans retinoic acid-induced differentiation of leukemic cells, reduced availability of glucose under hypoxia downregulates HIF-1 in part through the inhibition of HIF-1 alpha mRNA translation, which is occasionally observed in pathophysiological situations such as ischemic diseases, It was shown that the persons with a heterozygotic genotype of HIF-1alpha were more predisposed to the latent hypoxia development during long stay in Antarctica., Stable HIF-1alpha silencing enhanced hypoxia-induced cell death in vitro due to a lack of cell cycle arrest., UBXD7 links p97 to the ubiquitin ligase CUL2/VHL and its substrate hypoxia-inducible factor 1alpha (HIF1alpha)., The role of hypoxia inducible factor-1 on the expression of cystic fibrosis transmembrane conductance regulator and chloride and water flux in intestinal cells is reported., E2-EPF UCP expression induced by growth factors or serum increased HIF-1alpha protein level under non-hypoxic conditions, suggesting that the Egr-1/SRF-UCP-VHL pathway is in part responsible for the increased HIF-1alpha protein level, Data show that CSB mutant cells are unable to react to hypoxic stimuli by properly activating the hypoxia-inducible factor-1 (HIF-1) pathway, a defect that is further enhanced in the event of a concomitant genotoxic stress., HIF1alpha polymorphisms are associated with hot flashes., Expression of HIF-1alpha in transplanted kidneys shows a significant correlation with the use of a deceased donor kidney and with cold ischemia time., The tubular and interstitial TGF-beta1 and HIF-1alpha expressions in chronic kidney allograft nephropathy are greater than in other groups., findings show that hypoxia dictates an anti-inflammatory program by driving expression of HIF-1alpha that acts to increase the number and suppressive properties of naturally occurring CD4(+)CD25(+) regulatory T cells, Results suggest that the signals evoked by hypoxia and after ethyl-3,4-dihydroxybenzoate treatment differentially regulate HO-1 mRNA expression through HIF-1alpha-independent mechanisms., HIF-1alpha-regulated glycolysis module is closely related to the aggressive phenotype of hepatocellular carcinoma, and ENO1, a glycolysis module gene, might have a role in preventing metastasis, Silencing of hypoxia-inducible factor 1alpha (HIF1alpha) led to Smad activation even under hypoxic conditions, indicating that HIF1alpha is required for bone morphogenetic protein repression., Stem cell factor -induced accumulation of HIF-1alpha is dependent on both the PI-3-kinase and Ras/MEK/Erk pathways., These results suggest that CCN2 regulates the expression of VEGF at a transcriptional level by promoting HIF-1alpha activity., The expressions of hypoxia inducible factor 1alpha, vascular endothelial growth factor-A, thioredoxin, and thioredoxin interacting protein were related to macrophage infiltration rather than neovascularization in carotid atherosclerotic plaques, Hypoxia-associated factor, a protein expressed in proliferating cells, binds and ubiquitinates HIF-1alpha in vitro, leading to its proteasome-dependent degradation, Data show that nitric oxide derived from S-nitrosoglutathione activates ASK1 in THP-1 human myeloid macrophages, induces accumulation of HIF-1alpha protein, and induces accumulation of p53 in normal but not HIF-1alpha knockdown THP-1 cells., Copper regulation of HIF1 activity is reported., HSP70-2 is transcriptionally upregulated by HIF-1 in cancer cells in response to hypoxia, Sphingosine kinase 1 is a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells., Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization, These results confirmed that tocotrienol has an inhibitory effect on angiogenic factor secretion from cancer cells and revealed the possible mechanisms., In epithelial ovarian tumors, clear cell adenocarcinomas showed the highest levels for both of HIF-1 and HIF-1alpha, while mucinous adenocarcinomas showed the lowest levels of both., expression of hypoxia-inducible factors 1 alpha and 2 alpha is dependent on mTORC1 and mTORC2, PlGF-mediated increased FLAP mRNA expression occurred via activation of phosphoinositide-3 (PI-3) kinase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and hypoxia inducible factor-1alpha (HIF-1alpha)., the potential use of Hypoxia-inducible factor 1 C1772T (P582S) polymorphism and expression analysis in providing a new prognostic factor for unfavorable disease outcomes in breast cancer, VEGF, HIF-1alpha, and predominantly PDGFRalpha are expressed in neoplastic cells in the majority of Hodgkin lymphomas., Stabilization of HGF mRNA by hypoxia is mediated, at least in part, by HIF-1., The sequence variants in the exon 12 of the HIF1A gene were not associated with pre-eclampsia in the Finnish population, HIF-1alpha expression occurs in early stages of colorectal carcinogenesis and achieves a maximum in the invasive stage independent of the metastatic status., histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF, Results suggest that STAT3 decreases the pVHL-mediated ubiquitination of HIF-1alpha through competition with pVHL for binding to HIF-1 alpha, and then stabilizes HIF-1alpha protein levels., Estradiol partially stimulated mesenchymal stem cell proliferation via HIF-1alpha activation and VEGF expression through PKC, PI3K/Akt, and MAPK pathways., Dual role for hypoxia inducible factor 1 alpha in providing a survival or death signal, based on hypoxia duration, and consider the nuclear transcription factor, CREB, to be a possible target for hypoxic therapy against leukemia disease., genetic variants of HIF1A (Hypoxia-inducible factor 1-alpha )and VHL(von Hippel-Lindau tumor suppressor protein) are not associated with acute mountain sickness symptoms that occur in Sherpas at extremely high altitudes, degradation under enzymatic hypoxia conditions depends on interaction with prolyl hydroxylases, our study demonstrates existence of a pro-survival HIF-1alpha-dependent autocrine feedback loop in normoxic, serum-deprived prostate cancer cells, Antisense HIF1A gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular cacinoma., Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis, The significant decrease in HIF-1alpha mRNA in skeletal muscle after hypoxic training suggests that transcriptional and post-transcriptional regulations of the hif-1alpha gene are different in muscle and leukocytes., LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to factor HIF1alpha and HIF2alpha expression. LDH5 expression is linked with activated VEGFR2/KDR expression, HIF-1alpha expression is a more significant adverse prognostic factor in the tonsil than in tongue cancer., Alpha-ketoglutarate abrogates the nuclear localization of HIF-1A in aluminum-exposed hepatocytes., mRNA amount increases during the first two hours of hypoxic exposure and then returned to baseline levels, HIF-1alpha and HIF-2alpha have divergent roles in colon cancer, subtypes of VHL mutations support an intermediate level of HIF-1alpha and HIF-2alpha regulation via a remnant VBC complex., HIPK2-mediated transcriptional regulation of HIF-1alpha that might play a critical role in VEGF expression., CO(2) pneumoperitoneum may accelerate the apoptosis of MKN-45 cells at higher pressures. HIF-1alpha is a crucial factor that affects gastric cancer cell apoptosis by downregulating the Bcl-2/Bax ratio., okadaic acid promotes angiogenesis through stimulation of Akt mediated HIF-1alpha translation., impaired regulation of HIF-1alpha is essential for the development of diabetic wounds, and stabilization of HIF-1alpha is critical to reverse the pathological process, HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma, These results indicate that HDAC4 and HDAC5 increase the transactivation function of HIF-1alpha by promoting dissociation of HIF-1alpha from FIH-1 and association with p300., functional inactivation of HIF-alpha by stimulation of FIH-dependent p300 contributes to the YC-1-induced deregulation of hypoxia-induced genes, nitric oxide synthase inhibitor nitro-l-arginine methyl ester further stimulated the cyclic hypoxia-driven HIF-1alpha accumulation, Hypoxia-inducible factor-1alpha and -2alpha additively promote endothelial vasculogenic properties., Data show that EPAS1 and VEGF, but not HIF1alpha, are overexpressed in pancreatic carcinoma., Effect of ROS on angiogenesis in tumors expressing hot-spot p53 mutants was correlated with their ability to increase a content of HIF1 transcriptional factor responsible for up-regulation of VEGF-A mRNAs., An association between expression of HIF-1alpha and VEGF-D suggests that these two angiogenic factors are essential in progression of esophageal squamous cell carcinoma., HIF-1alpha is upregulated early in prostate cancer development with subsequent downregulation at later metastatic stages, HIF-1alpha directly bound to the promoter of FoxM1, hypoxia-inducible factor-1alpha is a direct target of the SWI/SNF chromatin-remodeling complex., Akt/mTOR-dependent translation of HIF-1alpha plays a critical role in the postirradiation up-regulation of intratumoral HIF-1 activity in response to radiation-induced alterations of glucose and oxygen availability in a solid tumor., HIF-1alpha-dependent repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine., The HIF-1alpha polymorphism may be associated with susceptibility to clinically localized prostate cancer but not with elevated expression of hypoxic biomarkers., HIF-1alpha and VEGF-C were over-expressed in non-small cell lung cancer., mAKAP organized ubiquitin E3 ligases that managed the stability of HIF-1alpha and optimally positioned it close to its site of action inside the nucleus, After treatment with everolimus, expression of p-mTOR, HIF-1alpha and VEGF was shown to be sharply depressed in clear cell adenocarcinoma, MGr1-Ag/37LRP is actively engaged by hypoxia and represent a novel HIF-1 target., Overexpression of HIPK2 resulted in subsequent inhibition of HIF-1 transcriptional activity, beclin-1 and HIF-1alpha expression are important determinants of survival in esophageal squamous cell carcinoma, Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1, These data suggest that hypoxia enhances the expression of MUC1 through the transcriptional regulation by HIF-1alpha in a human lung epithelial cell line., HIF-1 alpha and GLUT-1 could cooperate with TGF-beta1, and TGF-beta1 might mediate cross-talk between the inflammatory environment and tumour with a favourable impact on patient survival in colorectal cancer, mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production, up-regulation of PDK2, attenuating PDH activity, thereby increasing pyruvate, resulting in HIF1alpha stabilization, LPA stimulates hypoxia-inducible factor-1-independent VEGF expression to promote tumor angiogenesis through activation of the c-Myc and Sp-1 transcription factors, results demonstrate a critical role for hypoxia-induced p38 MAP kinase pathway in androgen-independent androgen receptor activation in prostate cancer cells, Rac1 is crucial to activate HIF-1 in RPE (retinal pigment epithelium) cells under hypoxia., HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells are inhibited by anthracycline chemotherapy, Hydronephrosis promotes expression of hypoxia-inducible factor 1 alpha., Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice., PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells, Endometrial stathmin is linked to HIF-1alpha protein accumulation and VEGF expression through the PI3K/Akt signaling pathway and may be involved in regeneration of the endometrium during the menstrual cycle in human uterine cells., Hypoxia promotes the expression of HPA and the invasiveness of SKOV3 cells through the HIF-1alpha pathway., results suggest that maintenance of cellular redox status by HIF-1 protects cells from hypoxia and ischemia mediated injuries, An increase in endothelial cell migration and in tubulogenesis in the course of hypoxia-reoxygenation cycles was evidenced, which was inhibited by HIF-1alpha siRNA., HIF-1alpha up-regulated CapG protein (but not transgelin)expression under normoxia, and knockdown of HIF-1alpha expression in pulmonary artery smooth muscle cells also inhibited hypoxia induced CapG up-regulation., endometrium with an abnormal location in patients with adenomyosis showed an increased VEGF and HIF-1alpha expression, activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression, HIF-1alpha-dependent BCL-xL overexpression may be an important mechanism by which HIF-1alpha protects prostate cancer cells from apoptosis and leads to treatment resistance, Data suggest that TGF-beta1 up-regulates angiotensinogen transcription through a mechanism that requires both JunD and HIF-1alpha binding to the AGT core promoter, and that a molecular mechanism links hypoxia signaling and fibrogenic stimuli in the lung., HIF-1alpha regulated hypoxia-induced CXCR4 expression in oral squamous cell carcinoma, gefitinib was able to circumvent hypoxia-induced drug resistance suggesting that the effective suppression of HIF-1alpha by the inhibition of EGFR-Akt pathway may overcome the hypoxia-induced drug resistance., Unlike other DNA damage response-inducing agents, RITA treatment of cells induced a p53-dependent increase in phosphorylation of the eif2 alpha, requiring PKR-like endoplasmic reticulum kinase activity, and led to the downregulation of HIF-1alpha, The accentuated expression at the invading edge together with the in vitro requirement of HIF-1alpha for migration, invasion and adherence argues for a pivotal role of HIF-1alpha in local invasion and, ultimately, systemic tumour spread., Data suggests that increased HIF-1alpha gene dosage is a mechanism of HIF-1alpha protein overexpression in head and neck squamous cell carcinomas that possibly prepares the cells for a higher activity in an intratumoral hypoxic environment., Pancreatic endocrine microadenomatosis in patients with von Hippel-Lindau disease, A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007). Hence, HIF1A Pro582Ser polymorphism is associated with muscle activity in humans., Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression., a new mechanism of oxygen-independent activation of HIF-1 has been identified that is mediated by SEPT9_v1 blockade of RACK1 activity on HIF-1alpha degradation, Type 2B R167Q mutant pVhl produces a unique profile of HIF dysregulation, thereby promoting tissue-specific effects on cell growth, development and tumor predisposition., data indicate that HIF-1-dependent inhibition of IL-8 expression is caused by downregulation of Nrf2. However, expression of IL-8 is independent of HO-1, MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells., histone demethylases are direct HIF targets, and their up-regulation helps maintain epigenetic homeostasis under hypoxic conditions, Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes., HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1., A gradual increase in COX-2 and HIF-1alpha protein expression was observed in dysplastic aberrant crypt foci, adenomas and carcinomas, showing a strong relation to dysplasia., studied 241 patients with AKI and determined the relationship to adverse outcome of a non-synonymous polymorphism in the coding region of the HIF-1alpha gene where a C to T substitution occurs at position +85 in exon 12, The results of the present study demonstrate that HIF-1alpha and HIF-1beta enhances expression of VEGF and glucose metabolism-related genes in response to hypoxia in gastric cancer., SNS-032 prevents hypoxia-mediated U87MG cell invasion by blocking the expression of HIF-1alpha and its trans-regulating factors, Interfering with HIF-1alpha pathways by siRNA strategy may provide a therapeutic target for human tongue squamous cell carcinomas., Overexpression of VEGF-A and cHIF-1alpha in tumor cells highlights a more aggressive subtype of clear cell renal cell carcinoma that might have some clinical implications, protein level and DNA binding are increased after rapid ascent to 4300 m, data show that HIF-1 alpha activates ER beta-mediated transcription in the absence of a ligand, and ER beta inhibits HIF-1 alpha-mediated transcription, PHD2 promotes growth factor-induced responses of human vascular smooth muscle cells, acting by HIF-1alpha-dependent mechanisms, RON is a novel molecular target of HIF-1alpha., cells containing complete HPV31 genomes showed enhanced levels of HIF-1alpha upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1alpha target genes., Both HIF-1 alpha and HSP70-2 proteins were strongly increased after HCC cells were exposed to hypoxic conditions., deficit in iodine is related to the release of VEGF-A via a reactive oxygen species/hypoxia-inducible factor-1-dependent pathway in thyroid, dynamic cytoplasmic-nuclear exchange of the fusion protein and HIF-1alpha was observed in NIH3T3 and HEK293 cells under different conditions (normoxia, CoCl2 treatment and hypoxia), isocitrate dehydrogenase-1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway, These results suggest a role for HIF-1alpha in the activation of JC virus; understanding of this pathway may lead to the development of more effective therapies for Progressive Multifocal Leukoencephalopathy., one of the major anti-angiogenic functions of EMAP-II is exerted through its inhibition of the HIF-1alpha activities, HIF-1alpha is important for the protection of these cells against TLR7/8-induced depletion of ATP., living high-training low induced a higher sensitivity of HIF-1 alpha mRNA to acute hypoxia in elite athletes., Within a tiled promoter array we identified 546 and 143 sequences that bound, respectively, to HIF-1alpha or HIF-2alpha at high stringency., HIF-1alpha expression could be detected in a COX-2-silenced breast cancer cell line., Substrate length has a much greater influence on FIH-1-dependent hydroxylation of Notch than of HIF-1alpha, predominantly through binding affinity rather than maximal reaction velocity., MTA1 may promote lung carcinogenesis by enhancing HIF-1alpha protein activity., SMG-1 negatively regulated HIF-1alpha activity in hypoxia, in part through blocking MAPK activation., HIF-1alpha expression was was significantly higher in lung cancer than in normal lung tissues., endotoxin tolerance impairs HIF-1alpha induction which reduces the ability of monocytic cells to survive and function under hypoxic conditions., Results show that HIF-1-active cells constitute a large proportion of invading and metastatic cells and suggest that eradication of these cells may improve the outcome in advanced pancreatic cancer, for which no effective therapy currently exists., ANK expression and function in vitro and in vivo are repressed in hypoxic environments and that the effect is regulated by HIF-1., Neuroblastoma cell adaptation to hypoxia involves the modulation of HIF1alpha and VEGF expression, nuclear translocation of ID1 and ID2 transcription factors, and activation of a gene expression program consistent with pro-metastatic events., HIF-1alpha, HIF-2alpha, or both HIF-1alpha and HIF-2alpha genes directly inhibited tumor cell proliferation., HIF-1alpha, but not HIF-2alpha, might be used as a marker of prognosis, in addition to methods currently used, to enhance rectal cancer patient management., rAAV-siHIF and L-ascorbate both affect biological behavior of hypoxic MiaPaCa2 cells through modulating HIF-1alpha protein expression., Results show that blockade of Akt/HIF-1alpha/PDGF-BB autocrine signaling could enhance the chemosensitivity of liver cancer cells and tumorigenic hepatic progenitor cells under hypoxic conditions and thus provide an effective therapeutic strategy for HCC., Polymorphisms in the hypoxia inducible factor 1-alpha is associated with oral cancer., Data suggest that IkappaB alpha, owing to its interactions with NF-kappaB and HIF-1alpha, may play a pivotal role in the crosstalk between the molecular events that underlie inflammatory and hypoxic responses., Data show that lysosomes degrade hypoxia-inducible factor-1a, and they are one of the targets through which 15d-PGJ2 accumulates HIF-1a in HK-2 cells., Data demonstrate that stable knockdown of FH in immortalized renal epithelial cells results in ROS-dependent HIF-1alpha stabilization., Late tumour stages of Kaposi sarcoma in tissues from HIV-positive patients are associated with high levels of LANA-1, HIF-1alpha and of the anti-apoptotic proteins, Bcl-2 and Mcl-1., The expression of HIF-1alpha was correlated with COX-2 in laryngeal squamous cell carcinoma., Castration-resistant cancers were characterized by reduced VEGF-A and increased HIF-1alpha expression, and vascular proliferation was associated with reduced patient survival in this group., The results showed that HIF-1alpha, a highly unstable subunit of the HIF-1, was stabilized in hepatitis E virus ORF3-expressing cells., KLF2 is a novel inhibitor of HIF-1alpha expression and function., This suggests that the targets of HIF-1alpha are secreted soluble factors rather than a cell-cell contact mechanism, and defines an important mechanism for the inhibition of human embryonic stem cell differentiation by hypoxia., 20-HETE may be a novel nonhypoxic regulator of HIF-1alpha and HIF-1alpha-regulated genes in microvascular endothelial cells, HIF-1alpha G1790A polymorphism may be associated with gastric cancer in Tibetans., activation of HIF-1 by hypoxia and dimethyloxaloylglycine (DMOG), a hypoxia mimic, diminished Ref-1 mRNA and protein expression in microvascular endothelial cells, Results identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha)., HIF-1alpha expression qualified as an independent prognostic and characterised an aggressive cancer phenotype associated with an increased expression of MT., LKB1- and AMPK-deficient mouse embryonic fibroblasts, show dramatic up-regulation of the HIF-1alpha transcription factor and its downstream transcriptional targets in an rapamycin-suppressible manner., These findings show that polymorphisms in the HIF-1alphagene do not confer susceptibility to lung cancer., Hypoxia and its simulant CoCl(2) can obviously down-regulate the expression of Foxp3, but this process is independent from HIF-1alpha., Results show that MUC1 is directly regulated by HIF-1alpha and affects the invasive and migration properties of renal cancer cells., The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta., In this study, pharmacologic concentrations of melatonin were found to inhibit expression of HIF-1 alpha protein under both normoxic and hypoxic conditions in DU145, PC-3, and LNCaP prostate cancer cells without affecting HIF-1 alpha mRNA levels., The high expression of HIF-1 alpha and VEGF in malignant melanoma indicates that they may play an important role in the generation and development of malignant melanoma., The high expressions of Prx1, Trx1 and HIF-1alpha were related to invasion and lymph node metastasis in papillary thyroid carcinoma., We found statistically significant HIF-1 alpha overexpression in psoriasis, Expression of HIF-1alpha and VEGF is greater in retinoblastoma with vasculogenic mimicry., polymorphic allele of HIF-1alpha C1772T may be associated with increased risk of developing breast cancer, and presence of 1772T allele may be a useful genetic marker for tumor prognosis., YC-1, a HIF-1 inhibitor, possesses several antiangiogenic properties, both in vitro and ex vivo., reviews role of HIF-1alpha in pathology of age-related macular degeneration and as possible therapeutic target [review], Studies show that reveal that only the structurally unique ETP core is required and sufficient to block the interaction of HIF-1alpha and p300., Results suggested that loss of coxsackie and adenovirus receptor in human cancer cell lines under hypoxic conditions occurs in an HIF-1alpha-dependent manner., results suggest that the survival-promoting function is crucial for OPN to promote the development of gastric cancer, and HIF-1 and MMP9 may play key roles during this process, VHL has both HIF-alpha dependent and HIF-alpha independent functions in regulating tight junctions and cell morphology, Genetic polymorphisms of HIF-1alpha were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients., Structural basis for binding of HIF1 to the oxygen-sensing prolyl hydroxylases is reported., HIF1A enhances HEK293 cell tolerance to oxygen and protease. Calcium inhibits expression of HIF1A., This work identified two novel direct targets of HIF-1 alpha targets, that are, S100 calcium-binding protein A4 and macrophage-capping protein., Findings indicate a novel mechanism by which hypoxia induces CD36 expression via activation of HIF-1 and the phosphatidylinositol 3-kinase pathway., Results reveal a unique function of HIF1alpha in up-regulation of PTEN and provide a new mechanism of reduced Akt phosphorylation in Tsc2 null cells., Thrombopoietin-activated HIF-1 functions as a sensor of ROS and blocks the overproduction of ROS by controlling PDK-1 expression and the subsequent inhibition of pyruvate dehydrogenase E1alpha unit., Report expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms. (Letter), SIM2s' functional interference with HIF1alpha activities on BNIP3 may indicate a novel role for SIM2s in promoting tumourigenesis., KLF5 is overexpressed in pancreatic cancer cells and exceeds KLF5 expression of KRAS-mutated colon cancer cells., NF-kappaB-HIF-1 interaction contributed to breast cancer metastatic capacity by means of an incomplete epithelial/mesenchymal transition and influencing migration., Measuring HIF1a, HB-EGF, and VEGF-C expression may contribute to a better understanding of the prognosis of patients with soft tissue sarcoma and may even play a crucial role for the distribution of patients to multimodal therapeutic regimens., heme oxygenase-1, hypoxia inducible factor-1alpha, and ubiquitin are involved in the development and progression of coronary heart disease, SENP3 is a redox sensor that regulates HIF-1 transcriptional activity under oxidative stress through the de-SUMOylation of p300, We confirmed the protective effect of a rare genetic variant of HIF-1alpha gene against type 2 diabetes in a Caucasian sample, and demonstrated a genetic contribution of the same polymorphism in type 1 diabetes, The findings shed light on a novel aspect of HIF-3alpha as a HIF-1 target gene and point to a possible role as a modulator of hypoxic gene induction., The interplays among HIF-1alpha and Hdm2 and HIF1 could be potential targets for treating tumors overexpressing HIF-1alpha., Suggest that a HIF-1 alpha/VEGF angiogenic pathway may exist in vivo in small cell lung carcinoma., show that Activating transcription factor 2 induction enhances HIF-1alpha protein stability via direct protein interaction., show here for the first time that hypoxia-induced HIPK2 deregulation was counteracted by zinc that restored HIPK2 suppression of HIF-1 pathway and reactivated p53 apoptotic response to drug, Compared to individuals with both C1772C and G1790G homozygotes, individuals with at least one of either C1772T or G1790A of HIF-1alpha gene had a risk of 2.17-folds (95% CI=1.0-4.75) to develop oral cancer., NOR-1 is a downstream effector of HIF-1 signaling involved in the survival response of endothelial cells to hypoxia., Results suggest that expressions of VEGF and HIF-1alpha could be involved in cervical carcinogenesis., BRCA1 cancers with positive HIF-1alpha or cytoplasmic FIH had a significantly shorter relapse-free survival., assessment of the HIF-1alpha expression in the resected tissues might predict the drug response to adjuvant 5-FU chemotherapy in advanced gastric cancer patients., the activity of HIF-1alpha is suppressed because of endogenous FIH-1 in HEK293 cells, and expression of Mint3 antagonizes this suppression., HIF-1alpha and TGF-beta may have roles in breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment, HIF-1alpha expression may be a useful indicator to predict the chemotherapy response and clinical outcome in gastric carcinoma., Eliminating hypoxic conditions or silencing HIF-1alpha by siRNA might provide a potent tool to enhance paclitaxel effectiveness in treatment of human ovarian cancer., HIF-1alpha as a mediator of neurodegeneration., these findings indicate that TNFalpha-induced HIF-1alpha accumulation is IKKbeta dependent, and may enable further understanding of the HIF-1alpha regulation by inflammatory signals., Data show that abrogating HIF-1alpha expression in basophils using siRNA demonstrated that this protein is essential for vascular endothelial growth factor (VEGF) mRNA expression and, consequently, release of VEGF protein., HIF1alpha, but not EpoR, was associated with the depth of myometrial invasion (p=0.04) and marginally with prognosis (p=0.07)of endometrial carcinomas., VEGF in CSDH, which may be induced in the neomembrane by HIF-1 release, may give rise to the excessive development of fragile microvessels and hyperpermeability, resulting in the enlargement of CSDH., mir-210 may account for at least part of the repressive effect of HIF1alpha on tumor growth., expression of HIF-1alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma, STC2 is a HIF-1 target gene and is involved in the regulation of cell proliferation., importins 4 and 7 accomplish nuclear import of HIF-1alpha more efficiently than the classical importin alpha/beta NLS receptor., HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress, Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation., Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha/vascular endothelial growth factor-mediated pathway in immunodeficient mice., Hypoxia induces epithelial-mesenchymal transition of alveolar epithelial cells through mitochondrial reactive oxygen species, HIF, and endogenous TGF-beta1 signaling., Data show that stimulation of HIF-1alpha transcription by the ND6 mutation was mediated by overproduction of reactive oxygen species (ROS) and subsequent activation of phosphatidylinositol 3-kinase (PI3K)-Akt and protein kinase C (PKC) signaling pathways., Data show that in hypoxic conditions or coexpressed with a constitutively active form of HIF-1alpha, c-Kit mutants activate the Ras/Raf/Mek/Erk pathway, stimulate proliferation and transform melanocytes., COMMD1 has a role in conjunction with HSP90beta/HSP70 in the ubiquitin and O(2)-independent regulation of HIF-1alpha, Data show that HIF-1 alpha mRNA expression increases in newborn infants with persistent pulmonary hypertension of the newborn or cyanotic congenital heart disease, as does the expression of its target genes VEGF and EPO., HIF-1 alpha was not found in normal thyroid. It was functionally expressed in thyroid carcinomas & regulated by hypoxia & growth factor signals, especially PI3K. HIF-1a expression may be partly responsible for CA-9 & GLUT1 rgulation in the disease., Expression of HIF1A and VEGF revealed divergent pH dependencies., Results confirm that HIF-1alpha plays an essential role in E(2)-induced expression of VEGF., Cell type-specific differences in HIF-1 binding were largely attributable to differences in the basal gene expression patterns in the cells prior to the onset of hypoxia., Adenosine, under hypoxia, stimulates HIF-1alpha accumulation by activating all adenosine receptors, Intravitreous VEGF and HIF-1a in diabetic patients with proliferative diabetic retinopathy (PDR) are increased and related mutually. VEGF and HIF-1a, especially VEGF, are associated with the angiogenesis of PDR., Data show that hypoxia induces TG2 expression through HIF-1 dependent pathway, and activation of TG2 inhibites caspase-3 activity by forming crosslinked multimer, and activates nuclear factor (NF)-kappaB pathway., Activation of endosomal TLRs 7, 8 and 4 leads to downregulation of degradative HIF-1 alpha prolyl hydroxylation., Hypoxic mature dendritic cells predominantly express adenosine receptor A2b., This review discusses current knowledge pertaining to the regulation of the HIF-1 signaling pathway and its potential neuroprotective role in mitigation or prevention of neurodegenerative diseases., Stabilization and transcriptional activation of HIF-1alpha in HCV infected liver cells induces glycolysis, Induction of JMJD1A by HIF-1 acts as an epigenetic signal amplifier to enhance cellular responses to hypoxia., activation of HIF-1alpha by hypoxia decreases HDAC2 levels, resulting in amplified inflammation and corticosteroid resistance., CBP is the coactivator directly interacting with HIF-1 alpha N-TAD and mediating the transactivation function of this domain in hypoxia, A region within the 5'-untranslated region of hypoxia-inducible factor-1alpha mRNA mediates its turnover in lung adenocarcinoma cells., Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells., HIF-1alpha and VEGF regulation by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration, beta-catenin-a marker of early stage of colorectal carcinogenesis, as well as TGF-beta1 and HIF-1alpha appear to be devoid of prognostic significance for colorectal cancer in this study of disease free survival, Active HIF-1 signaling occurs constitutively in the normal human and rat retina, suggesting that HIF-1 has a physiological role in the retina., HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma, HIF-1alpha expression was an independent predictor of cancer-specific survival in clear cell RCC with sarcomatoid differentiation, plays a role in regulation of EPO production in kidney tubules. (review), The expression of HIF-1alpha in circulating tumor cells of patients with metastatic breast cancer could explain the metastatic potential of these cells., Increased HIF-1alpha expression under normoxic conditions contributes to some of the malignant phenotypes exhibited by human melanoma cells., Data show that the AS E-box was bound by HIF-1alpha in all the three melanoma cell lines, and nder arginine depletion conditions, HIF-1alpha was replaced by c-Myc in A2058 and SK-MEL-2 cells but not in A375 cells., Hsp70- and CHIP-dependent ubiquitination represents a molecular mechanism by which prolonged hypoxia selectively reduces the levels of HIF-1alpha but not HIF-2alpha protein., Studies explore the VHL-HIF-VEGF pathway that plays a fundamental role in the development of renal cancer., HIF-1alpha in hepatocellular carcinoma plays an important role in predicting patient outcome, HIF-1alpha plays an important role in B cell development., The expression of HIF-1alpha was correlated with size, stage, lymph node metastasis and histological grade of laryngeal cancer., Expression of alternative splice variant HIF1alpha-2 increased in peripheral-blood-derived mononuclear cells after a 1h aerobic exercise. Baseline expression of HIF1alpha-2 but not HIF1alpha-1 was igher in the follicular phase than in the luteal phase., The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF., Tristetraprolin is a modulator of HIF-1alpha expression during hypoxia and may play a physiological role in regulation between cellular adaptation and apoptosis in prolonged hypoxia., HIF1A gene in HMC-1 immature hematopoietic cells is suppressed by a process dependent on DNA methylation., Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes., PAK-1 and its activator Rac1 are novel HIF-1 targets that may constitute a positive-feedback loop for induction of HIF-1alpha by thrombin and ROS, thus explaining elevated levels of PAK-1, Rac1, and HIF-1alpha in remodeled pulmonary vessels., preoperative radiotherapy downregulates HIF-1alpha expression in rectal cancer, HIF-1alpha and VEGF could be used as biomarkers indicating tumors in advanced stage and independently implied poor prognosis in patients with colorectal cancer, sprinter performance is determined by the interaction between the wild-type HIF1A Pro/Pro genotype and ACTN3 RR genotype, Identify CXCR4 as a key player in the endothelial cell response to acidic pH and indicate a role for HIF-1alpha., The expression of VEGF seems to be associated with COX-2, HO-1 and adipogenesis related genes., these results demonstrated that hypoxia-inducible factor 1alpha played a crucial role in regulating the transcription of DcR2., Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha, and SLUG regulation of MT4-MMP transcription., Overexpression of HIF-1alpha is associated with relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-fluorouracil chemotherapy., HIF-1alpha expression is positively correlated with VEGF expression in non-small cell lung cancer., The overexpression of HO-1 in hypoxic HepG2 cells is HIF-1alpha-dependent., molecular pathway from hypoxia to cellular transformation includes up-regulation of HIF and subsequent transcriptional induction of LOX and LOXL2, which repress E-cadherin and induce epithelial to mesenchymal transition, Regulation and expression of both PHD2 and HIF-1a are important to the biology of sarcomas, and loss of PHD2 function has an additional adverse effect in the prognosis of sarcomas in tumors expressing HIF-1a., The main hallmarks of oncocytic transformation, namely the occurrence of homoplasmic disruptive mutations and complex I disassembly, may explain the benign nature of oncocytic neoplasms through lack of HIF1alpha stabilization., our findings recognize the PHD/HIF regulatory axis as a novel therapeutic target to disable a tumor's ability to adjust to hypoxic conditions and control cell survival, Results reveal that some strains of Gram-positive bacteria exploit hypoxia-inducible factor 1 alpha-regulated platelet-activating factor receptor as a means for translocation through intestinal epithelial cells., Analysis revealed a somatic HIF1A missense substitution, p.Val116Glu, in a single RCC. Functional studies demonstrated that p.Val116Glu impaired HIF-1alpha transcriptional activity., the HIF-1alpha 1772 C/T polymorphism is significantly associated with higher cancer risk, and 1790 G/A polymorphism is significantly associated with decreased breast cancer risk, Studies indicate that the loss of HIF-1 activity results in a dramatic decrease in tumor growth and vascularization., Using RNA interference the authors show that bacteria-induced HIF-1alpha regulates the expression of IL-8, VEGF and Twist1, thereby pointing to a role for HIF-1 in angiogenesis and inflammation., persisting low temperature significantly reduced HIF-1alpha neosynthesis under hypoxic conditions, leading to a decrease in gene expression for adaptation to hypoxia in both in vitro and in vivo settings, There is an independent role of ACE and HIF1A in predisposing to cellulite, may provide novel information on the pathophysiology of this common cosmetic problem., Data found that reovirus infection suppresses hypoxia inducible factor (HIF)-1alpha protein levels (but not transcript abundance) in colon cancer HCT116 cells under CoCl(2) or hypoxia., The data suggest that neither HIF1alpha nor CUL2 mutation may play a central role in HIF1alpha activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias., these data suggest that hypoxia promotes oral squamous cell carcinoma cell invasion that is elicited by HIF-1alpha-dependent alpha5 integrin and fibronectin induction., Intermittent hypoxic exposure can enhance serum hypoxia inducible factor-1 alpha and erythropointin levels., These genes might be regulated by the SOX2 transcription factor as potential secondary HIF1 targets., Tirapazamine can down-regulate hypoxia-induced expression of HIF-1alpha and OPN mRNA of HNE-1 cells and radiosensitize the HNE-1 cells but not CNE-1 cells., These findings indicate that alterations of nitric oxide and MnSOD contribute to pathological HIF-1alpha expression and account for lower numbers of mitochondria in idiopathic pulmonary arterial hypertension-endothelial cells., Elevated expression level of HIF1A is associated with a low response to chemoradiation in rectal cancer., Cutaneous angiosarcoma generally lacks HIF-1alpha expression so the hypoxic response pathway is not thought to be a documentable common mechanism of angiogenesis in this entity, Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1., Findings show that oxidative stress and FOXO4 induce PAI-1 expression through modulation of HIF-1alpha and CREB protein levels and that enhanced CREB binding to the PAI-1 promoter is critical for the PAI-1 induction under oxidative stress., YC-1 has a significant effect on down-regulating the protein expression of HIF-1alpha and VEGF, and induces the apoptosis in U937 cells., previously unsuspected collaborative regulation of HIF-1alpha by TNFalpha/IL-4 and hypoxia in bronchial epithelial cells partially via PI3K-mTOR and NF-kappaB pathway, Inhibition of HIF-1 alpha expression in ovarian cancer cells by specific siRNA resulted in a significant decrease in VEGF production and angiogenesis., miR-31 contributes to the development of head and neck squamous cell carcinoma by impeding FIH to activate HIF under normoxic conditions., HIF-1alpha expression is strongest in the sub-lining layer of rheumatoid arthritis synovium and is related to both angiogenesis and inflammation in synovium from rheumatoid arthritis patients., Data suggest that HIF-1alpha-associated Beclin 1 high expression might facilitate nasopharyngeal carcinoma cells surviving from chemoradiotherapy, suggesting a novel therapeutic molecular target for NPC., PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation., EGFR signaling can regulate MET levels through HIF-1alpha and that MET is a key downstream mediator of EGFR-induced invasiveness in EGFR-dependent NSCLC cells., Mitochondria and HIFs are intimately connected to regulate each other resulting in appropriate responses to hypoxia., Expressions of HIF-1 show mutual correlations in primary ductal breast cancers, which suggest co-operation among the protein., These are the first data that demonstrate an influence of betacellulin upon mesenchymal stem cells and the first to implicate HIF-alpha in betacellulin-mediated proliferation., Our findings suggest that ELL and HIF-1alpha are binding partners and can modulate the functions of each other in hypoxia., Sensitivity of ovarian cancer cells to p38 blockade seems to rely on a shift from HIF1alpha- to FoxO3A-dependent transcription, which is promoted by the activation of the adenosine monophosphate-activated protein kinase pathway., Data suggest that betulinic acid may have anti-angiogenic potential by inhibition of prolidase, HIF-1alpha and VEGF expressions, and inhibition of collagen biosynthesis., Tumor cells deprived of glutamine showed HIF-1alpha accumulation in the absence of glucose, proposing that enhanced glutaminolysis observed in many tumors enables these cells to compensate reduced oxoglutarate production in the absence of glucose., Hypoxia augmented binding of HIF-1alpha to hypoxia-response elements in 5-lipoxygenase activating protein promoter, Mutation of lysine 532 of HIF-1alpha in B16F10-mARD1A(225) cells prevented HIF-1alpha degradation and inhibited the antimetastatic effect of mARD1A(225) (P < .001)., HIF-1alpha in coordination with vWF may play an important role in the pathogenesis of pre-eclampsia., Xenografts derived from mixed populations of HIF-1alpha-positive and HIF-1alpha-negative glioblastoma cells were more aggressive than those obtained by grafting each cell population separately., Uterine leiomyomas are severely and uniformly hypoxic, but do not induce HIF-1alpha, HIF-2alpha, glucose transporter (GLUT)-1 or carbonic anhydrase (CA) IX., HIF-1 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells, Expression of HIF-1alpha and MDR1/P-gp in colon carcinoma and HIF-1alpha expression may be associated with the gene MDR1 (P-gp) and interactively., data support the idea that modulation of carcinogen metabolism may be an important mechanism for the observed HIF-1-mediated genetic instability, suggesting a potential role in cancer development, Hypoxia enhances BMP-2 expression in osteoblasts by an HIF-1alpha-dependent mechanism involving the activation of ILK/Akt and mTOR pathways., VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner., CYR61 and NOV are regulated by HIF-1alpha and TGF-beta3 in the trophoblast cell line JEG3, and their enhanced secretion could be implicated in appropriate placental invasion., We found preliminary evidence that the HIF1A Pro582Ser polymorphism and a common haplotype of the HIF1A gene may be associated with EEA status in Caucasian men., Knockdown of PIASy by small interfering RNA leads to reduction of VHL oligomerization and increases HIF1alpha degradation, 12-LOX increases the protein level, mRNA, and functional activity of HIF-1alpha in prostate cancer cells under hypoxic conditions, one of the mechanisms by which it upregulates VEGF secretion and activity, The binding between p16 and HIF-1a protein may alter HIF-1a's ability to transactivate VEGF expression in breast tumor cells., the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1alpha, which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3, Nrf2-dependent Trx1 induction turned out to enhance HIF-1 alpha signaling in intermittent hypoxia., Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury., The data indicate that blocking hypoxia-inducible pathways by antisense HIF-1alpha can circumvent hypoxia-induced drug resistance and thereby augment the efficacy of anti-angiogenic therapies., HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers, Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation, expression of HIF-1alpha was higher in oral lichen planus than in controls, Nitric oxide (NO) induces HIF-1alpha stabilization in human endothelial cells from umbilical cords under normoxic conditions. Loading of the cells with vitamin C counteracted NO-induced HIF-1alpha accumulation., Hypoxia-inducible factor 1 alpha-deficient hepatocellular carcinoma cells displayed significantly reduced anchorage-independent growth and enhanced sensitivity toward etoposide, while basic cellular proliferation was unaffected., HPSE, HIF-1alpha and VEGF play a role in tumor angiogenesis and promote malignant progress of retinoblastoma., Hif-1alpha is required for chondrogenesis in vivo by controlling a complex homeostatic response that allows chondrocytes to survive and differentiate in an hypoxic environment., Manipulation of HIF-1 does not influence angiogenesis of the skull bones, where earlier activation of HIF-1 in the condensing mesenchyme upregulates osterix during cranial bone formation., the pro-apoptotic mechanisms orchestrated by p38(MAPK) in human keratinocytes in response to ultraviolet rays B involve an HIF-1/Noxa axis, HIF-1alpha and VEGF did not appear to be related to clinical outcomes in stage III colorectal cancer patients., An acute dose of albendazole in profoundly suppresses both HIF-1alpha and VEGF within ovarian tumors., Insights and validation are provided for interaction of septin 9 transcript variant 1 as a potential target for antitumor therapy via interruption of the HIF-1 pathway., results do not confirm an implication of HIF-1alpha gene polymorphisms in the susceptibility to and clinical expression of giant cell arteritis, Subsets of patients with colon adenocarcinoma demonstrate specific protein/gene alterations regarding EGFR/VEGF/HIF1a molecules., Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 and not by HIF-2., Net and HIF1alpha are components of distinct signaling pathways that are intricately linked, data suggest that HIF-1alpha-deficient Mcapital EF, Cyrillics develop a more prominent tumor-associated macrophages (TAMs) marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs, These data suggest an important role of the signaling axis between NOX4 and HIF-1alpha in various cardiovascular disorders under hypoxic and also nonhypoxic conditions., IGF-1 increases expression of HIF-1 through activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) signaling pathway and leads to increased VEGF secretion, which enhances excitatory synaptic transmission, Overexpression of HIF1-alpha is associated with colon cancer., Results show increased mucosal HIF-1alpha expression in celiac disease (CD) and suggest the contribution of this signaling pathway in the pathomechanism of CD., The constitutive activation of the transcription factor HIF-1alpha in high-grade chondrosarcoma could play a central role in the regulation of cell metabolism and vascularization in these tumours., tasquinimod-induced up-regulation of TSP1 is part of a mechanism involving down-regulation of HIF1alpha and VEGF, which in turn leads to reduced angiogenesis, Hypoxia-inducible factor-1alpha is expressed in papillary thyroid carcinomas and is regulated not only by hypoxia but also by BRAF(V600E)-mediated signaling pathway., the expression of miR-101 is also modulated at different physiological conditions, such as androgen stimulation and HIF-1alpha/HIF-1beta induction., Both HIF-1 and HIF-2 serve as negative regulators of ANK expression in the disc. We, Propose that HIF-1 is centrally involved in carotid artery remodelling in response to arterial injury and that localized inhibition of HIF-1 may be a novel therapeutic strategy to prevent carotid stenosis., Low-dose fractioned irradiation can lower MDR1 and HIF1alpha expressions in esophageal cancer cells., A positive correlation was found between the expressions of HIF-1alpha and MMP-2 in degenerative intervertebral discs., The aggressive stem cell-like phenotype of breast cancer cells is induced by inflammatory cytokine TNF-alpha activation SLUG via NFkB/HIF1a, which is further enhanced by the loss of p53 function., HIF-1alpha-knockdown increases HIF-2alpha expression and shifts the balance of Bcl-2 family members toward cell survival., Hypoxia-inducible factor-1alpha induces down-regulation of CDX2 in colon carcinoma cells and Snail may be involved in this regulation process., Development of a controlled and comparative HIF-1alpha immunoassay., knock down of HIF-1alpha in human and murine glioma cells impairs their migration in vitro and their invasion in vivo., HIF1A increases galectin-1 expression in both messenger RNA and protein levels in colorectal cancer., Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin., The expression of HIF-1alpha and GLUT1 proteins was increased after CoCl(2)-induced hypoxia in all breast cancer cell lines tested, HIF-1alpha is an independent prognostic marker in oral squamous cell carcinoma., Insulin dose-dependently increased the HIF-1alpha protein expression, and YC-1 could dose-dependently block this effect in PANC-1 cells., The expression of TLR4 and HIF-1alpha had a significant impact on survival of patients with pancreatic adenocarcinoma., present work suggested that HIF-1alpha and HIF-2alpha were involved in metastasis and invasion of gastric cancer cells under hypoxia, with the involvement of JNK signal pathway, Both HIF-1alpha and HIF-2alpha are activated in close correlation with retinal hypoxia but have contrasting cell specificities, consistent with differential roles in retinal ischaemia, Bortezomib may down-regulate the expression of VEGF in endothelial cells through regulating the activity of HIF-1alpha and the expression of Annexin A2., Hypoxia inducible factor-1alpha has a role in human emphysema lung tissue, Intratumoral hypoxia in breast cancer is marked by coordinated expression of such markers as HIF-1alpha, Glut-1, leptin and ObR. The relationships among these proteins can be altered by preoperative chemotherapy., Single nucleotide polymorphisms in the HIF1A gene and colorectal neoplasms are reported., the underlying mechanism by which ET-1, through the regulation of PHD2, controls HIF-1alpha stability and thereby regulates angiogenesis and melanoma cell invasion, Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling., High HIF1alpha expression was associated with strocytic tumors associated with necrosis., There is no consistent relationship between LMP1 and either HIF-1alpha expression or degree of microvasculature in nasopharyngeal carcinoma, p70S6K1 is required for tumor growth and angiogenesis through HIF-1alpha and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling., crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction., These results show for the first time that mRNA expression of a HIF-1alphaTAG splice variant reflects a stage of breast cancer progression and is associated with a worse prognosis., HIG2 is a direct and specific target of HIF-1, REVIEW, SDF1 transcriptional up-regulation after ionizing radiation is mediated by both HIF1A dependent and -independent mechanisms in endothelial cells., is possible that upregulation of HIF-1/VEGF is involved in the enhancement of MMP-9 expression under hypoxic conditions., HIF-1alpha gene polymorphisms investigated in this study were not found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer, Activation of HIF-1 is a general phenomenon in infections with human pathogenic bacteria, viruses, fungi and protozoa, Genetic polymorphism at G1790A of HIF-1alpha is an important factor for determining the susceptibility to hepatocellular carcinoma, HIF1A1 C1772T and G1790A polymorphisms are not involved in the progression or metastasis of colorectal cancer., Differences in the basal level of HIF-1alpha expression in different prostate cancer cell lines underlie their differential response to TLR3 activation, suggesting a correlation between hypoxic gene expression and tumor responsiveness to TLR agonists., These findings may suggest a correlation between the HIF-1alpha C1772T and G1790A polymorphisms and the growth of oral squamous cell carcinoma, and the decrease of its recurrence frequency., This study focuses on the influence of HIF-1alpha on regulation of TRAIL apoptotic activity in hypoxic tumor cells., Studies define an important role of PIASy in hypoxia signaling through promoting HIF1alpha SUMOylation., TLR4-mediated SphK1 activation was found to be critical for the redox-dependent activation of HIF-1alpha and ASK1, and the prevention of lipopolysaccharide-induced activation of caspase 3 and the expression interleukin-6., increased HIF-1alpha levels mediated up-regulation of Bcl-xL play a prominent role in evasion of apoptosis and tumor progression, Cytoplasmic stabilization of HIF1alpha in neuroendocrine differentiated cells is associated with benign and malignant prostate tissue and is due to presence of an HIF1alpha isoform, HIF1alpha1.2., Results demonstrate that HIF is sufficient to enhance osteoclast-mediated bone resorption and that ANGPTL4 can compensate for HIF-1alpha deficiency with respect to stimulation of osteoclast activity and augments osteoblast proliferation and differentiation., Study identified the stabilization of HIF-1alpha protein as a mechanism through which bcl-2 induces the activation of HIF-1 in hypoxic tumour cells involving the beta isoform of molecular chaperone HSP90., AQP5, HIF-1alpha, VEGF are all involved in edema formation in nasal polyps. HIF-1alpha and VEGF can induce new blood vessels and increase vasopermeability in nasal polyps., Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production., HIF-1alpha expression is associated with occurrence and development of hepatocellular carcinoma., Data in colon cancer tissue microarray showed that thymosin beta4 and HIF-1alpha co-localized in these biopsies., HIF-1alpha as a potent regulator of p53 and NF-kappaB activity under conditions of genotoxic stress, Evidence accumulated during the past 7 years suggests a critical role for HIF-1-alpha in mediating cardioprotection., Results suggested that the suppression of HIF-1alpha accumulation by IDPm knockdown in PC3 cells was due to an inhibition of HIF-1alpha transcription., indispensable role of HIF1alpha in maintaining the thermogenic functions of BAT, possibly through promoting angiogenesis and mitochondrial biogenesis in this tissue., RNA interference of HIF-1alpha prevents hypoxia-induced increase in vascular endothelial cell permeability., These results suggest that carbon monoxode stimulates VEGF production by increasing HIF-1alpha protein level via two distinct mechanisms, translational stimulation and protein stabilization of HIF-1alpha., DNA methylation analysis of the HIF-1alpha prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas, Culture of primary AML cells under low oxygen tension induces HIF-1alpha expression and increases the release of several cytokines, including proangiogenic mediators, compared to culture at ambient 21% O(2), The HIF-1alpha showed promoting roles in tumor angiogenesis and growth, and therapeutic outcome may benefit from combined targeting of HIF-1alpha, Hypoxia is associated to angiogenesis in solid tumors and hypoxia-inducible factor (HIF)-1alpha is a critical trigger and regulator of the angiogenic switch., aberrant activation of HIF-1 in malignant lymphoma cells was mediated, at least in part, by NF-kappaB activity., Interaction of hypoxia-inducible factor-1alpha and NOTCH1 regulates medulloblastoma precursor proliferation and fate., A pathogenetic role in mantle cell lymphoma; HIF-1alpha appears to be associated with more aggressive disease., a novel link between APC and hypoxia and show that APC and HIF-1alpha antagonize each other, Overexpression of HIF1A is associated with gastric adenocarcinoma., T/C and T/T genotypes of HIF-1alpha C1772T are genetic susceptibility factors for cervical cancer in the Han population in Sichuan province of China., Thrombin upregulates Twist via HIF-1alpha to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis., Hypoxia inducible factor 1 alpha subunit activation in different cell types can either promote or repress tumorigenesis., iNOS and HIF-1alpha are highly expressed in psoriasis and might play an important role in the genesis and development of psoriasis., HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment., miR-210 regulates mitochondrial function by targeting key electron transport chain component genes with important consequences on cell metabolism, survival and modulation of HIF-1 activity., Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia., results show that CHMP4A significantly enhances the stability and transcriptional activity of HIF-1alpha both under normoxic and hypoxic conditions, Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha, HIF-1alpha(+) cells in pancreatic ductal adenocarcinomas and nonmalignant pancreatic tumors differ not only in their amounts but also in their relation to intratumoral blood vessels., The inhibition of HIF-1alpha inhibits the invasion, tube formation, and cell growth in HUVECs and HCC cells., Conclude that functional polymorphisms in the HIF1A gene do not contribute to susceptibility to peripheral arterial disease., HIF1A gene is under hypoxic selection induced by high altitude in the three groups., Tendon retraction in full-thickness medium-sized rotator cuff tears is characterized by neovascularity and increased expression of hypoxia inducible factor 1alpha and vascular endothelial growth factor., The potent induction of HIF-1alpha protein involved in its cytotoxicity, together with the suppression of HIF-1 transcriptional activity, indicates the great therapeutic potential of triptolide as an anticancer drug., CBP/p300, which interacts with the transactivation domains of HIF-1alpha, is important for HIF-1alpha-induced transcription of angiogenic genes., Hypoxia facilitates HIF-1alpha up-regulation in Human aortic smooth muscle cell in addition to driving enhanced secretion of MMP-2 and MMP-9, molecular studies led to the discovery of a previously unappreciated HIF-1 binding site in the FADD promoter, which controls repression of FADD during hypoxia., ET-1-mediated MIP-1beta gene expression is regulated via hypoxia-response elements, AP-1, and NF-kappaB cis-binding elements in its promoter and negatively regulated by microRNA-195, which targets the 3' untranslated region of MIP-1beta RNA, HIF-1, CXCR4, and VEGF high expression levels in colon cancer were correlated positively with TNM stage, lymph node involvement, and distant metastasis., Nuclear expression of HIF1A by the tumor cells is associated with deep myometrial invasion in endometrioid carcinoma., Analysis of renal carcinoma cells for expression of HIF-1a and HIF-2a confirmed high levels of hypoxia inducible factor in cells lacking functional von Hippel-Lindau (VHL) tumour suppressor., Studies indicate that HIF2alpha is selectively expressed in the CD133+ subpopulation of glioblastoma cells, whereas HIF1alpha expression is widespread among both tumorigenic and nontumorigenic cells., Elevated HIF-1alpha gene expression was associated with poor overall survivalin rectal cancer, These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis, and regulate HIF-1alpha isoforms.., Ulip1 was downregulated and HIF1a was upregulated in hypoxic neuroblastoma cells., For the first time, clinical and functional abnormalities in the HIF-1 pathway are demonstrated during hypoxia in monocytes from sporadic amyotrophic lateral sclerosis patients., HIF-1alpha, HIF-2alpha and CAIX were up-regulated in 88.2% (15/17), 100% (17/17) and 88.2% (15/17) of CCRCC tumors respectively and their expression is independent of VHL status., Review, Our results provide novel and highly unexpected insights into the complexity of HIF-1alpha regulation in cancer cells and implicate that tumor-associated CpG demethylation augments HIF-1alpha-mediated effects on malignant cell growth., ROS mediated HIF-1alpha activation is a crucial mechanism involved in hypoxia-induced differential radioresistant in U87 gliomas., Of specimens with VHL alterations 95.6% tested positive for EPO. EPO was identified in 96.2 and 94.2% of HIF-1alpha and HIF-2alpha positive specimens, respectively, compared to 72.4 and 53.8% for HIF-1alpha and HIF-2alpha negative groups (p<0.01)., HIF-1alpha is inhibited by siRNA or chetomin in human malignant glioma cells, TGF-beta1 activates VEGF expression via multiple routes including Smad3, HIF-2alpha and HuR signaling, XOR promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, PPARgamma SUMOylation, and HIF-1alpha, HIF-1 plays a role in Hyperthermia-induced tumor reoxygenation by transactivating its downstream targets., Concomitant expression of HER2 (protein tyrosine kinase-type cell surface receptor HER2 ) and HIF-1alpha (hypoxia inducible factor 1 alpha) is a predictor of poor prognosis in uterine cervical carcinoma treated with concurrent chemoradiotherapy, Report nuclear co-localization and functional interaction of COX-2 and HIF-1alpha characterize bone metastasis of human breast carcinoma., Regression analysis showed that HIF 1alpha was not an independent prognostic factor for survival in SCC of the esophagus in our study on European population., Data reveal that HIF-1alpha and HIF-2alpha work together to modulate cancer metabolism and regulate genes signature overlapping with oncogenic KRAS., high expression in squamous cell lung carcinoma is associated with a poor survival, Data show that the inhibitory effect of TPZ on HIF-1alpha protein synthesis is dependent on the phosphorylation of translation initiation factor 2alpha (eIF2alpha)., HIF-1alpha and CA IX were over expressed in nasal polyps., HIF-1alpha has an important role in up-regulating MICA expression, inducing IFNgamma secretion and NK cell cytotoxicity during hypoxia/reoxygenation., Hypoxia results in ataxia telangiectasia mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1alpha) on serine(696) and mediates downregulation of mTORC1 signaling., overexpression of Tbeta4 is strongly associated with HIF-1alpha and HIF-2alpha expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer, Data shows that increased association of Hsp40/70 with HIF-1alpha led to recruitment of CHIP, which promoted polyubiquitination and degradation of HIF-1alpha., HIF-1alpha and MRP1 may play a role in the multidrug resistance of chordoma to chemotherapy., telomerase expression and activity are induced through both direct phosphorylation of hTERT by phospho-AKT as well as PI3K-dependent transcriptional regulation involving Hif1-alpha as a key transcription factor, The protein expression levels of VEGF and HIF-1alpha were decreased in HepG2 cells subjected to hypoxia acclimatization compared to cells treated with acute hypoxia., Silencing HIF1a increases the apoptosis ratio in human gastric cancer cell in a high pressure environment., overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma, HIF-1alpha is an outcome marker for normal karyotype acute myeloid leukemia ., Zinc downregulates HIF-1alpha and inhibits its activity in tumor cells in vitro and in vivo, NHE1 might participate in HIF-1-induced angiogenesis due, at least in part, to the alteration of calpain activity., NF-kappaB-mediated inflammatory signaling is able to block HIF-1alpha transactivation at hypoxia response elements-encoding genes by direct competition for p300 binding at the promoter., HIF-1 signaling underlies the increase of FBLN5 expression elicited by hypoxia in endothelial cells suggesting that FBLN5 induction could be involved in the adaptive survival response of endothelial cells to hypoxia, NEDD8 is an ancillary player to regulate the stability of HIF-1alpha, HIF1-mediated ALAS2 upregulation promotes erythropoiesis to satisfy the needs of an organism under hypoxic conditions., 1, 9 PA may enhance the response of cancer cells to cetuximab through a complementary effect on the downregulation of HIF-1alpha, Elevated expression of HIF-1alpha is associated with early-stage cervical cancers., Microtubule integrity and dynamics are intricately involved in orchestrating HIF-1alpha translation., The CRE-like site located near the SBE may contribute to the formation of a stable complex of STAT3, HIF-1alpha, and p300/CBP, which leads to maximum transcription of the Hp gene., This study examined levels of hypoxia inducible factor-1alpha (HIF-1alpha) protein in 40 laryngeal squamous cell carcinoma specimens using immunohistochemistry., these findings provide compelling evidence that LOX and HIF-1 act in synergy to foster tumor formation, Hypoxia-inducible factors (HIFs)have been identified as key mediators of adaptation to hypoxia., These findings identify a novel circuitry between HIF-1alpha and p53, and provide a paradigm for HIPK2 dictating cell response to antitumor therapies., Celastrol regulates HIF-1alpha at multiple levels that may together or individually contribute to its antitumor activity against hypoxia-induced angiogenesis and metastasis., Serum levels of HIF-1alpha, ET-1 and iNOS increase in neonates with hypoxia-induced pulmonary hypertension (HPH), resulting in an imbalance of ET-1 and NO. This may be of importance in the pathogenesis of neonatal HPH., HIF-1alpha regulates the expression and function of its downstream target genes, COX-2 and VEGF, which play a critical role in the angiogenesis of laryngeal carcinoma, CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway., These findings identify snail as a HIF target gene., HSF2 and HSF4 regulate transcription of HIF-1alpha and that a critical balance between these HSFs is required to maintain HIF-alpha expression in a repressed state., ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene, HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling, In the HER2 overexpression type and triple-negative breast carcer, tumor cell proliferation and survival in the hypoxic tumor environment could possibly be due to disinhibition of the mTOR pathway and HIF-1alpha stabilization by downregulation of REDD1., The expressions of HIF-1alpha and VEGF in synovial tissue are significantly higher in osteoarthritis cases than in cases of acute traumatic arthritis., Data highlight NRF2 as a candidate molecular target to control tumor angiogenesis by imposing a blockade to HIF-1alpha signaling., HIF-1alpha induction of genetic alteration is the underlying cause of tumor progression, especially by the hypoxic microenvironment., Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition, This study suggested that CT genotype and the T allele of HIF-1alpha C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China., Data show that VEGF-C and HIF1a mRNA were significantly upregulated in oxaliplatin-related SOS., In conclusion, although HIF-1alpha genetic polymorphisms appear to have little association with cervical cancer risk and prognosis, individual variance of HIF-1alpha gene may be associated with cervical cancer invasiveness., In MCF-7 cells, the activation of HIF1 on the novel hypoxia response element contributes to the breast cancer-specific hypoxic induction of GAPDH gene expression and absolutely depends on the presence of Sp1 on the GC-box., Data supports activation of a central IL6-STAT3-HIF1A pathway in OCCA., The T-allele of HIF1A P582S was associated with greater gains following endurance training in young women., Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner, These results identify adrenomedullin as an endogenously generated vascular mediator that functions as a mucosal protective factor through fine tuning of HIF activity., Phosphatidylinositol 3'-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression in hypoxia., Dual-luciferase reporter assay showed that iron regulatory protein 1 (IRP)1 was directly downregulated by hypoxia-inducible factor 1/hypoxia response element system., Data conclude that HIF-1alpha and HIF-2alpha may differentially regulate the major angiogenic factors in different stages of the tumor process in NSCLC., There was no association between the genotype of HIF1A SNP and clinicopathological parameters of colorectal cancer. There is an association between the HIF1A 1772C/T SNP and developing colorectal cancer, especially in individuals older than 60 years., Suppressing HIF-1alpha expression in clear cell renal cell carcinoma cell line prevented FIH-1 knockdown from increasing apoptosis, Melatonin inhibited the stability of HIF-1alpha in a time- and concentration- dependent manners. Also, melatonin decreased SPHK1 activity in PC-3 cells during hypoxia., SIRT3 expression is reduced in human breast cancers, and its loss correlates with the upregulation of HIF1alpha target genes., Results showed that exposure to Nano-Ni caused HIF-1alpha accumulation in the nucleus of U937 cells., HIF-1alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs., lowered expression is associated with decreased overall survival in gallbladder cancer patients, As HIF-1 is linked with an efficient immune response and pulmonary complications in cystic fibrosis, this difference in HIF-1alpha protein levels could have an impact in the CF pathology and the persistence of P. aeruginosa infection., Prolyl hydroxylases (PHD3) regulate the transcriptional activity of HIF-1alpha. This could be potentially inhibited by polynitrogen compounds., The expression of HIF-1alpha was positively correlated with the size of the cancer., HIF-1alpha was expressed in all tumor cells lines studied, with the highest expression in the MDA-MB-231 cell line., functional polymorphisms in the HIF-1alpha gene may have an important impact on lung carcinogenesis, especially in adenocarcinomas, possibly by increasing genomic instability, results show that ER-beta suppresses HIF-1alpha-mediated transcription via aryl hydrocarbon receptor nuclear translocator (ARNT)downregulation, which may account for the tumour suppressive function of ER-beta, Inhibition of HIF-1 activation by using HIF-1alpha-targeted siRNA clearly acts synergistically with radiotherapy and increase radiosensitivity of hypoxic cells in vitro., Coexpression of high levels of HIF-1alpha and GLUT-1 is significantly correlated with prognosis in oral squamous cell carcinoma patients., The role of DDX3 as a hypoxia-inducible gene that exhibits enhanced expression through the interaction of hypoxia inducible factor-1 with hypoxia inducible factor-1 responsive elements in its promoter region, is reported., findings show that monocyte-derived dendritic cells, exposed to hypoxia, expressed high levels of the hypoxia-inducible factor (HIF)-1alpha, associated with upregulation of BNIP3 and BAX expression, Hypoxia upregulates low-density lipoprotein receptor-related protein-1 expression and aggregated low-density lipoprotein-derived intracellular cholesterol esters accumulation in human vascular smooth muscle cells through HIF-1alpha induction., these observations show that hypoxia-stabilized HIF-1a induces the repression of the ESR1 gene, which may facilitate hormone insensitivity in the tumor microenvironment., hypoxia-induced MAT2A expression is HIF-1alpha dependent, honokiol can exert its anticancer activity as a HIF-1alpha inhibitor by reducing HIF-1alpha protein level and suppressing the hypoxia-related signaling pathway, The cellular protein hypoxia-inducible factor 1 alpha (HIF-1alpha) was induced after infection of human fibroblasts with human cytomegalovirus (HCMV)., ZNF217 is overexpressed in GBMs and contributes to the maintenance of GSCs, which is regulated by HIFs released by the hypoxic environment of the tumor, mutations on ARNT PAS-B modulate coactivator selectivity and target gene induction by HIF in vivo, demonstrating a bifunctional role for transcriptional regulation by PAS domains within bHLH-PAS transcription factors, hypoxia upregulates RANK and RANKL expression and increases RANKL-induced cell migration via the PI3K/Akt-HIF-1alpha pathway., The expression of HIF-1alpha mRNA is closely related to the staging of colorectal cancer., Expression of DLL4, VEGF and HIF-1alpha was very strong in gliomas., HIF-1alpha expression is increased in patients with asthma and rhinitis after allergen challenge., depletion of hypoxia inducible factor 1 alpha subunit suppressed the tumorigenicity of esophageal carcinoma cells in vivo, HIF-1alpha mediates hypoxia-induced up-regulation of RANKL expression, HIF-1alpha expression in cardiosphere-derived cells (CDC) blunted the beneficial functional effects of CDC transplantation, suggesting that paracrine factor balance may play an important role in cardiac regeneration., HIF-1alpha and microlymphatic vessel density play important roles in the development of rectal cancer,which may promote lymphatic micrometastasis., RTEF-1 as a regulator of HIF-1alpha transcription, Epidermal growth factor receptor-mediated signaling pathways are important in regulating cigarette smoke-induced Hypoxia inducible factor-1 activation and MUC5AC expression., The impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue, was evaluated., hypoxia-induced miR-210 represses GPD1L, contributing to suppression of prolyl hydroxylases activity, and increases of HIF-1alpha protein levels., Underexpressed miR-199b, which may be via the upregulation of Hif1alpha in hepatocellular carcinoma, is inversely correlated with survival and directly correlated with the malignant status of HCC patients., the TSC/mTOR/HIF axis is activated by the KSHV vGPCR in Kaposi's sarcoma, which amplifies the angiogenic signal, OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization, these results have provided new mechanistic insights into the differential regulation of HIF-1alpha and HIF-2alpha by the hypoxic tumor microenvironment., hypoxia decreases MSC cell migration through an HIF-1alpha and RhoA-mediated pathway, Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells., HIF1-alpha gene silencing can regulate the growth cycles of HepG2 cells, promote cell apoptosis and inhibit cell proliferation., these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer., Results confirm that HIF-2alpha is tumor suppressive, and suggest that HIF-1alpha may also be tumor suppressive., hypoxia-induced expression of AQP1 requires transcriptional activation, and the HIF-1 binding site of the 5'-promoter is necessary for transcriptional activation, an increase in the NCX1 mRNA due to the apoptosis induction is not regulated by HIF-1alpha, High Coexpression of HIF1alpha and NOTCH1 is associated with Non-Small-Cell Lung Carcinoma., Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1alpha and PKM2 coactivator function; PKM2 participates in a positive feedback loop that promotes HIF-1 transactivation and reprograms glucose metabolism in cancer cells., results establish the interplay between JMY and HIF-1alpha as a new mechanism that controls cell motility under hypoxic stress, Over-expression of miR-22 inhibits HIF-1alpha expression, repressing vascular endothelial growth factor (VEGF) production during hypoxia., There is a role for HIF-1alpha in cutaneous angiogenesis, skin tumorigenesis, and several skin disorders., elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression, HIF-1 pathway inhibition may be mediated by the inhibition of mitogen-activated protein kinases., HIF-1alpha expression in primary hepatocellular carcinoma was associated with External beam radiotherapy response of abdominal metastatic lymph nodes and poor prognosis., Wnt/beta-catenin signaling pathway might be a necessary endogenous signal that directly controlled the Epithelial-Mesenchymal transition occurrence induced by HIF-1alpha., This is the first report that examined HIF1A polymorphisms in chronic obstructive pulmonary disease and demonstrated a possible role of HIF-1alpha in COPD, as well as GSTP1 and EPHX1., new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells, Immunohistochemical analysis of early-stage breast cancer, HER2-related breast tumors with high hypoxia, as well as normal basal epithelial cells, express increased mRNA levels of HIF-1alpha compared to luminal types and silencing of HIF-1alpha results in decreased expression of hypoxia-induced genes, ANGPTL4 is a target gene of HIF-1alpha and acts as an important regulator in the metastasis of hepatocellular carcinoma., It was shown that beta-arrestin1 robustly interacts with nuclear HIF-1alpha and potentiates HIF-1alpha-dependent transcription of vascular endothelial growth factor-A., show that the perpetual EMT driven by chronic hypoxia depends on HIF-1alpha induction of genetic alterations rather than its canonical transcriptional activator function, Parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIFalpha., protein stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells, the C1772T and G1790A single nucleotide polymorphisms in the HIF-1 alpha gene increase the susceptibility to pancreatic cancer., Findings show that the combination of intratumoral HIF-1alpha, VEGF, and MMP-2 may be useful as a molecular prediction model for LNM., FIH-1 expression does not seem to explain the proposed functional differences between diffuse and perinecrotic HIF-1alpha expression in breast cancer., Cell inflammation reaction and apoptosis induced by HIF-1alpha may participate in the mechanism of hypoxia inducing low endometrial receptivity., our fi ndings reveal a direct link between cyclin E and HIF-1 activities in mammary epithelial cells and implicate HIF-1 as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers., Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia., Studies indicate that HIF transcriptionally activates several genes implicated in clear-cell RCC pathogenesis, including VEGF., we speculate that the effects of hypoxia are not due to HIF-1, but are caused by the activation of NFkappaB, GDF-15 promoted angiogenesis in hypoxic HUVECs possibly through inhibiting p53 signal, which subsequently enhanced and stabolized HIF-1alpha expression, and up-regulated the related downstream angiogenic signaling., TTP physiologically controls the expression of a panel of HIF-1alpha target genes. These data reveal a new role for TTP in the control of gene expression during the response of endothelial cell to hypoxia., VHL and HIF1A polymorphisms may not influence renal cell carcinoma (RCC) susceptibility but may jointly influence RCC progression and survival., Compared with normoxia, hypoxia elevated the expression of CD133, CXCR4 and HIF-1alpha. Moreover, hypoxia facilitated the invasiveness of CD133+ pancreatic cancer cells., DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line., The serum HIF-1alpha has high expression in PHC. The serum HIF-1alpha expression has close relation with the whether distant metastasis of tumor., cross-talk of signalling pathways associated with HIF-1 activation, HIF-1alpha may play a role in the early stage of breast carcinogenesis., HIF-1alpha possesses a MAPK docking domain; this finding provides a link between the MAPK signaling cascade and the hypoxia-induced signaling pathway and their possible roles in tumorigenesis., Data suggest that miR-155 induction contributes to an isoform-specific negative-feedback loop for the resolution of HIF-1alpha activity in cells exposed to prolonged hypoxia, leading to oscillatory behavior of HIF-1alpha-dependent transcription., HIF-1alpha is overexpressed in bladder tissue and VEGF is overexpressed in umbrella cells from patients with interstitial cystitis, Data suggest that the levels of HIF-1alpha and NF-kappa-B transcription factors in vitreous humor are not increased in proliferative diabetic retinopathy., Hypoxia-inducible factor-1alpha (HIF-1alpha) induced activation of Notch pathway is essential for hypoxia-mediated maintenance of glioblastoma stem cells., Suggest the possible involvement of Hif-1alpha/PDGF-BB pathway in the development of HIV-1 associated pulmonary arterial hypertension., HIF-1alpha overexpression significantly promoted hemorrhagic transformation in pituitary adenoma, Taken together, these findings identify HIF-1alpha as responsible for upregulation of Mcl-1 and the maintenance of apoptosis resistance during Chlamydia infection., Hypoxia, as indicated by HFI-1alpha expression, might be related to the worse prognosis found in CD44+CD24-/low positive breast tumors., study indicates that the KLHL20-mediated PML degradation and HIF-1alpha autoregulation play key roles in tumor progression, in the first stages of clear cell renal cell carcinoma formation the stabilization of HIF-1alpha dominates, limiting proliferation, as the HIF-2alpha ratio increases, a more aggressive cell behavior emerges, High HIF-1alpha is associated with angiogenic potential in human small cell lung carcinoma., Increased HIF1alpha expression may contribute to the increase in glycolytic flux and lactate production in pyruvate dehydrogenase complex deficiency., Upregulation of COX-2 and HIF-1alpha in response to hypoxia is suppressed by dihydrotestosterone via an androgen receptor-independent mechanism., HIF-1alpha mutants were more effective for enhancing angiogenesis in ischaemic muscle tissue than wild-type HIF-1alpha., inhibition of HIF-1 activity in BrCa cells inhibits primary tumor growth and metastasis of BrCa cells to the lungs by blocking expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM);ANGPTL4 inhibits endothelial cell(EC)-EC interaction; L1CAM increases the adherence of BrCa cells to ECs, miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of clear cell renal cell carcinoma cells., There is no association between HIF1-a and PlGF in any melanoma type. Hypoxia, in the expression of HIF1-a, plays a key role in melanoma progression; it activates VEGF secretion, which induces angiogenesis and metastasis. Role of PlGF seems to be limited., the mechanisms for galectin-1 expression regulation and HIF-1alpha- and C/EBPalpha-induced leukemic cell differentiation., Tumor size, HIF-1alpha, and phos-S6 expression were found to be independent predictors of both DSS and tumor progression in primary clear cell renal cell carcinomas., hypoxia or overexpression of HIF-1alpha induces the epithelial to mesenchymal transition that is largely dependent on NF-kappaB in pancreatic cancer cells, HIF-1alpha was associated with the presence of metastases at time of diagnosis and time of relapse. HIF-1alpha is likely to play a role in progressive prostate cancer., Antisense transcripts are activated in response to different kinds of stress. 5'aHIF-1alpha accumulates at the perinuclear cellular compartment and colocalizes with nuclear pore complex Nup62 protein., A constitutively activated human HIF1alpha, (P402A, P564A, N803A) in mouse proximal tubule cells is sufficient to promoter cell proliferation, angiogenesis, genomic instablity & other phenotypic changes of Von Hippel Lindau disease., Results show carbonic anhydrase 9 (mRNA and protein), and HIF-1alpha protein are overexpressed in a significant portion of WTs., Metastatic niche formation is an HIF-1-dependent event during breast cancer progression, HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia, HIF-1alpha contributes to epithelial to mesenchymal transition and chemoresistance induced by hypoxia, HIF-1alpha enhanced neo-microvascularity in a hypoxic environment and increased drug resistance in pancreatic cancer, The antiangiogenic and anti-inflammatory effects of EC-SOD might be due to suppression of hypoxia-inducible factor-1alpha expression., loss of epithelial barrier integrity by oxidative stress is minimized by activation of HIF-1, in part by induction of sestrin-2, anterior cruciate ligament cells responded to hypoxia by up-regulating the HIF-1alpha expression significantly as compared to medial collateral ligament cells, Hypoxic pulmonary hypertension is closely associated with increased expression of HIF-1alpha and VEGF in high altitide areas., variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia, The present study shows that the HIF-1alpha G1790A polymorphism and its protein expression have an impact on the prognosis of upper aerodigestive tract carcinoma patients, Findings suggest that hypericin may potentially be useful in preventing growth of tumors in which HIF-1alpha plays pivotal roles., Studies indicate that HIF-1alpha, CAIX and VEGF were expressed in OSCC., Hypoxia-induced migration of HSC/MFs involves an early, mitochondrial-dependent ROS-mediated activation of ERK and JNK, followed by a delayed- and HIF-1alpha-dependent up-regulation and release of VEGF., data introduce a new mechanism for regulation of HIF-1alpha during hypoxia that utilizes phosphorylation to target HIF-1alpha for ubiquitin-dependent degradation through FBW7 and may identify new targets in the regulation of angiogenesis, downregulation of HIF-1 through EGFR signaling seems to be required for the induction of a positive response to EGFR-targeted therapies in TNBC, HIF-1-mediated VLDLR induction influences intracellular lipid accumulation through regulating LDL and VLDL uptake under hypoxia., genetic association studies in population in Republic of Korea, Study demonstrated that hypoxia-induced HIF-1alpha expression involves a cascade of signaling events including ROS generation, activation of PI3K and ERK signaling, and subsequent activation of Rac1., HIF-1alpha immunoreactivity in substantia nigra neurons is significantly increased in five of six patients with restless legs syndrome, compared with controls., The study pointed out the direction for further research to find indicators for tumor invasiveness and the possibility of practical use of HIF-1a as important methods for determining changes in laryngeal cancer, The overall results point towards a novel ability of HDM2 in regulating HIF-1alpha and p-STAT3 levels even in normoxic conditions that eventually lead to an up-regulation of VEGF expression., Findings show a link between hypoxia-induced accumulation of HIF-1alpha, increased expression of ADAM10, and decreased surface MHC class I chain-related molecule A levels leading to tumor cell resistance to lysis mediated by innate immune effectors., RSUME critically regulates HIF-1a and VEGF-A production and thus might play an important role in pituitary tumour neovascularisation, CCN5-induced inhibition of TWIST1 expression is mediated through the translational inhibition/modification of hypoxia-inducible factor-1alpha via impeding JNK signaling pathway, These findings indicate that activation of the HIV-1 LTR by Vpr is HIF-1alpha dependent., HIF-1alpha may be involved in the pathogenesis of prion-related diseases and as such may be a therapeutic target for prion-related neurodegenerative diseases., This study identifies RhoE as a direct target for HIF-1 in gastric cancer cells., HIF1alpha activity is diminished in 14q-deleted kidney cancers, and all somatic HIF1alpha mutations identified in kidney cancers tested to date are loss of function., YC-1 inhibits HIF-1alpha and HIF-1alpha-mediated gene expression, cell proliferation and migration activity and induces apoptosis in hypoxic bladder transitional carcinoma cells., HIF1-mediated GATA1 up-regulation promotes erythropoiesis in order to satisfy the needs of an organism under hypoxic conditions., By allying with HIF1alpha, RORgammat wins the fight against FoxP3 and Treg cell commitment., High glucose activates HIF-1alpha mediated gene expression regulation in glomerular mesangial cells, which causes diabetic nephropathy., Hypoxia increased HIF-1alpha and iNOS expression in HaCaT cells and inhibition of HIF-1alpha expression decreased iNOS expression., sequential activation of two transcription factors, HIF and Sp1, is required to stimulate transcription of Abcc8 following cerebral ischemia., LiPopolySaccharides induces the nuclear accumulation of HIF-1alpha in human gingival fibroblasts and induces HIF-1 biologic activity under normoxia or hypoxia possibly through TLR4., HIF-1alpha and HIF-2alpha induce transcription of Kaposi's sarcoma-associated herpesvirus LANA., Non-metal binding hypoxia mimetics, and hypoxia inhibit TNFalpha-mediated VCAM-1 expression via HIF1a/2a mechanism in endothelial cells., Constitutive activation of signal transducers and activators of transcription 3 correlates with better prognosis, cell proliferation and hypoxia-inducible factor-1alpha in human gastric cancer., HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter, CoCl(2) dose- and time-dependently increases the expression of HIF-1alpha, and significantly inhibits the proliferation of HL-60 cells., ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha and rescues it from degradation independent of its catalytic activity, Data suggest that conditions that mimic hypoxia increase vascular endothelial growth factor (VEGF) expression via HIF-1a and decrease stromal cell-derived factor-1 (SDF-1) expression in HIF-1a-independent manner in endometrial stromal cells., This analysis reveals a surprising cancer cell line specific variation of HIF activity in the same level of hypoxia., HIF-1alpha may regulate the expression of EPO, which plays a favorable regulatory role in the proliferation and survival of human first-trimester trophoblast cells and decidual stromal cells, A new pathway that could be targeted at the level of GSK-3, Fbw7, or USP28 to influence HIF-1alpha-dependent processes like angiogenesis and metastasis., we have demonstrated that HIF-1alpha and HSP90 play an important role in the tumorigenesis of papillary thyroid carcinoma, Angiogenesis and the expressions of CD82 and HIF-1alpha are related to differentiation, lymph node metastasis and clinical staging in non-small cell lung cancer., In non-smallcell lung cancer higher odds ratios for lung cancer were observed for individuals with HIF-1a-1772 T/T genotype against CC/CT genotypes, and HIF-1a-1790 A/A genotype against GG/GA genotypes., Inflamed ileum of Crohn disease patients abnormally expressed HIF-1a., Liquiritigenin inhibits serum- and mimicked hypoxic-induced HIF-1alpha protein accumulation in HeLa cells., HDAC7 reduction in COPD causes a defect of HIF-1alpha induction response to hypoxia with impaired VEGF gene expression. This poor cellular adaptation might play a role in the pathogenesis of COPD., When the monochorionic twin placenta is formed in the early period, HIF-1alpha, VEGF and VEGFR-1 are over-expressed, which may affect the placenta angiogenesis and induce twin-twin transfusion syndrome., our findings uncover a previously uncharacterized regulatory relationship between Myc and HIF1 that has important implications for cancer metabolism and development., down-regulation of the deregulated HIF-1alpha blocks Hsp90alpha secretion and invasion of the cells, HIF-1alpha-mediated upregulation of fibrogenic growth factors induced by ligation of Kalpha-1T antibodies is critical for development of fibrosis leading to chronic rjection of lung allografts., The results indicate a role of HIF-1alpha in skin homeostasis especially during epidermal aging., inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3 by decorin, the mTOR-HIF-1alpha-VEGF pathway affects the progression of oral squamous cell carcinomas, Carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 have roles in disease outcome in rectal cancer, Results suggest that FOXO3a and HIF-1alpha may be considered to be important prognostic markers in nasopharyngeal carcinoma., HIF-1alpha might reduce proliferation and survivin expression in primary human osteoblasts independently from cellular hypoxia. HIF-1alpha promoted the loss of the characteristic osteoblastic marker, osteocalcin in vitro., 2012 May 16 (10, These results identify FHL proteins as negative regulators of HIF-1 activity, which may provide a mechanism by which they suppress tumor growth., Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta, High HIF1-alpha is associated with small cell lung cancer., Data indicate that chronic HIF-1alpha stabilization drives autonomous pathways that add to progression of heart disease., PRMT5 probably promotes tumor growth by stimulating cell proliferation and by participating in the construction of a tumor-favorable microenvironment via HIF-1 activation., Report distinctive response patterns of HIF-1alpha, CYP3A4 and CYP3A7 to cobalt chloride in human fetal liver cells., Exposure of varicose veins to hypoxic conditions was associated with increased expression of HIF-1alpha and HIF-2alpha protein and HIF target genes., Data show that the tumour suppressor protein LIMD1 acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1alpha., High HIF-1alpha is associated with ovarian cancer invasiveness, [review] Apart from traditional oxygen dependent HIF regulation, the focus on studies of HIF activity has now shifted from ischemic injury toward oxygen independent regulation in a cell specific manner., visceral adipose tissue from human obese subjects is characterized by high levels of HIF1alpha and low levels of SIRT2, Data indicate that intracellular prostaglandin E(2) increases HIF-1alpha expression and mediates all-trans-retinoic acid (ATRA)-induced hypoxia-inducible factor-1alpha (HIF-1alpha) up-regulation., soluble ErbB4 intracellular domain promotes HIF-1alpha stability and signaling via a novel mechanism., Linear regression analysis revealed no correlation between basal HIF-1alpha levels and the survival fraction at either 2 or 4 Gy in all tumor cell lines investigated., Although HIF-1 alpha expression is a common finding in adenoid cystic carcinomas, it cannot be used as a marker of tumour aggressiveness., a novel TNF-alpha/HIF-1alpha/VASP axis in which HIF-1alpha acts downstream of TNF-alpha to inhibit VASP expression and modulate the adhesion and proliferation of breast cancer cells, The role of matrix metalloproteinases (MMPs), hypoxia-inducible factor-1alpha (HIF), and vascular endothelial growth factor (VEGF) in the hypertrophied ligamentum flavum, was investigated., role in nasal polypogenesis via induction of epithelial-to-mesenchymal transition, Hypoxia suppresses esophageal carcinoma cell migration and invasion through hypoxia inducible factor-1 alpha activation., Taken together, our study provides the evident of the function of HIF-1alpha/MMP-1 in regulating metastasis of bladder cancer, the higher expression of HIF-1alpha and MT in varicocele and varicose veins than in the control group; MT overexpression in the muscle layer of both diseased vessels and especially located in the endothelium, results suggest that exposure to nicotine could mimic effects of hypoxia to stimulate HIF-1alpha accumulation and activity that might underlie the high metastatic potential of lung cancer, Overexpression of HIF-1a was found to be an indicator of poor prognosis for patients with gastric cancer and was significantly correlated with histology, depth of invasion, VEGF, and MVD., Runx2 stabilizes HIF-1alpha by binding to ODDD to block the interaction between von Hippel-Lindau protein and HIF-1alpha., HIF-1alpha regulation is microtubule-independent, and likely contributes to the chemoresistant nature of renal cell carcinomas., Digoxin is a potent inhibitor of HIF-1alpha signaling pathway and blood vessel formation in C4-2 castration-resistant prostate tumors., findings identified HIF-1 and NOX2 as partners acting in concert to promote angiogenesis in response to U-II, polymorphism at on chromosome 11q13.3 modulates the binding and function of hypoxia-inducible factor at a transcriptional enhancer, ADM up-regulated the protein expressions of HIF-1alpha through down-regulation of proline hydroxylase (PHD) mRNA expression and PHD activity., HCV core protein enhances the expression of HIF-1alpha and VEGF in Huh7.5.1. cells., CAV1 is a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor., our study establishes IGFBP3 as a direct HIF-1alpha target gene and that polysome enrichment of IGFBP3 mRNA may permit continuous translation under hypoxic conditions, HIF1alpha exerts a negative control over beta-cell differentiation, HIF-1 alpha is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal., study demonstrated that the formation of cancer stem cell-like cells undergoing process of epithelial-mesenchymal transition-like associated with overexpression of HIF-1alpha, both of which are regulated by miR-21, The results show that HIF1A may influence the degree of branching in the human coronary tree., Elevated HIF-1alpha expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy., the increased NO levels in hypoxic HEK293 cells help stabilize HIF-1alpha., The expression of both HIF-1alpha and VEGF were not significantly increased in BNIP3 positive clear cell renal cell carcinoma in comparison with BNIP3 negative tumors., studies identify HIF1alpha as a key protein in regulating transcription of XPA in lung cancer cell lines and primary tumors contributing to cisplatin resistance, As a critical mediator in vasculogenic mimicry formation, high expression of HIF-1alpha was associated with vasculogenic mimicry and tumor progression in gallbladder carcinoma patients., HIF-1alpha accumulation is critical for sustaining human allergic effector cell survival and function., HIF-1alpha binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke, HIF-1alpha directly bound to hypoxia-responsive element located at -419 to -414 of ARC gene, which is essential for HIF-1-induced expression., Frequency of the HIF1A Pro/Ser genotype (32.28 vs. 18.91%; p = 0.006) and Ser allele (16.93 vs. 10.00%; p = 0.01) were significantly higher in the rowers compared with those in controls., Urinary HIF-1alpha levels were elevated in LN patients and were associated with histologic chronicity changes and renal function, indicating that HIF-1alpha might contribute to histologic chronicity in LN., Data suggest that HIF-1alpha and SIRT1 proteins interact in hepatocellular carcinoma (HCC) cells and that HIF-1alpha is a target of SIRT1 deacetylase activity., Omi/HtrA2 expression is inversely correlated with HIF-1alpha expression in hepatocellular carcinoma., studies identify adenosine-elicited stabilization of Per2 in the control of HIF-dependent cardiac metabolism and ischemia tolerance and implicate Per2 stabilization, identified hypoxia and HIF-1 as novel regulators of S100A8/A9 expression in prostate cancer. S100A9 might be useful as prognostic marker for prostate cancer recurrence after radical prostatectomy, Cancer cells after surviving radiation acquire HIF-1 activity and translocate towards tumour blood vessels., Data show that growth arrest-specific 6 (GAS6) and receptor tyrosine kinase Axl is colocalize with hypoxia-inducible factor-1alpha (Hif-1alpha) in both primary tumors and bone metastasis in prostate tumor tissue microarrays samples., Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha., Data indicate that the invasion potencies were decreased more in ZnSO4-treated cells than in control cells after siRNA-mediated knockdown of hypoxia-inducible factors HIF-1alpha and/or HIF-2alpha., Case Report, Data suggest that vasohibin inhibits cell proliferation of umbilical vein endothelial cells through degradation of HIF-1alpha via proline hydroxylase during oxidative stress., HIF-1alpha was increased significantly in patients with neuroblastoma associated with unfavourable characteristics, demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors, hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms, While affected by HIF-1, HO-1 up-regulation promotes the expression of HIF-1 and the down-regulation of HO-1 suppresses the expression of HIF-1 gene., Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer., The expression of nuclear HIF-1alpha was correlated with CD133., we present here data suggesting that p21 and hif1alpha mRNA plasma expressions may be used as markers for complicated pregnancies, analysis of the effect interstitial fluid pressure on hypoxia-inducible factor (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human osteosarcoma xenografts in SCID mice and in different hypoxic environments, action of HIF-1alpha on TMPRSS6 promoter activity, Results suggest that HIF-1alpha is a vital biomarker for predicting the progression and prognosis of myelodysplastic syndromes (MDS)., IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation., HIF1 mainly binds to the intergenic regions distal from transcriptional starting sites under both normoxia and hypoxia., The C1772T polymorphism causes activation of HIF-1alpha as a gain-of-function mechanism driven by stabilization of HIF-1alpha mRNA., The HIF-1 activation in the absence of WRN involves the generation of mitochondrial reactive oxygen species since SkQ1, a mitochondrial-targeted antioxidant, and stigmatellin, an inhibitor of mitochondrial complex III, blocked increased HIF-1 levels., enhanced HIF-1alpha translation as molecular mechanism in HIF-2alpha knockdown (k/d) cells, Differential HIF-1 transcriptional activity under mild or severe oxidative stress results from altered HIF-1alpha/p300 binding., Dihydrotestosterone induced HIF-1alpha expression in male human umbilical vein endothelial cells., These studies underline the importance of mTOR as a fundamental regulator of HIF-1 signalling in myeloid cells., Data suggest that a combination of beta-elemene with HIF-1alpha inhibitor might be a useful therapeutic option for osteosarcoma., HIF-1alpha mediates the extracellular antimicrobial activity of mast cells by increasing the formation of mast cell extracellular traps, results demonstrated that JMJD2B was induced under hypoxia in an HIF-1alpha-dependent manner in colorectal cancer cells, Report increased expression of HIF-1alpha and Bcl-2 in varicocele and varicose veins and increased Bcl-2 expression especially in the endothelium under hypoxia., Overexpression of HIF-1alpha attenuated the inhibitory effects of UVA irradiation on the stemness of human adipose tissue-derived mesenchymal stem cells., The present study is the first to demonstrate the increased expression of HIF1alpha in patients with shock, HIF-1alpha may promote the expression of GLUT-1 and VEGF in laryngeal carcinoma, which promotes tumor angiogenesis, invasion, and metastasis., Germ cell tumors of the testis, regardless of the histologic type, are characterized by consistently low HIF-1alpha protein overexpression., HIF-1alpha is significantly upregulated in lung during allergic response., In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer., Overexpression of HIF-1alpha is associated with hepatocellular carcinoma., Hypoxia-inducible factor-1alpha (HIF1alpha) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release, panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease, activation of the aerobic glycolytic pathway, corresponding to the Warburg effect, occurs in EBV-transformed lymphoblastoid cells, in contrast to mitogen-activated B-cells, Prolyl hydroxylase domain-containing proteins may be involved in the process of hypoxic pulmonary vascular remodeling in chronic obstructive pulmonary disease via regulation of HIF-1alpha gene expression., Findings suggest the HIF-1/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma., analysis of coordinated action of hypoxia-inducible factor-1alpha and beta-catenin in androgen receptor signaling, MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer, Ethanol is able to enhance arsenic-induced tumor angiogenesis in colorectal cancer cells via the HIF-1alpha pathway., HIF-1alpha increased cell adhesion and migration and plays crucial role in mesenchymal stem cell biology., Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1alpha., HIF1alpha acts as a tumor promoter in stromal cells but as a tumor suppressor in cancer cells., a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation., JNK2 regulated nucleolin expression and might in turn stabilize hif-1alpha mRNA., The presence of the TT and GA variants of HIF 1A were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size in squamous-cell carcinoma of the glottic larynx, TTP-driven HIF-1alpha mRNA stabilization is crucial for cell migration., The inhibition of HIF-1alpha expression by MNP loaded with HIF-1alpha siRNA (MNP(siHIF)) blocked PC3 cell proliferation., Show that the administration of melatonin inhibits tumor growth and blocks tumor angiogenesis in mice. Moreover, melatonin diminished the expression of the HIF-1alpha protein within the tumor mass during tumorigenesis., Data suggest that survivin expression in up-regulated following induction of HIF1A by cellular hypoxia in cervical cancer cells possibly leading to tumor formation and possibly to tumor progression., Our results establish a mechanistic linkage between 2 critically important molecules in cancer, identifying CD24 as a critical HIF-1alpha transcriptional target and biologic effector, role of Hif1-alpha in the pathology of renal cell carcinomas, hypoxia-inducible factor-1alpha (HIF-1alpha) has a radiation protective effect on human oral squamous cell carcinoma cell lines, Hyperbaric oxygenation combined with As(2)O(3) can increase the expression of caspase 3 mRNA and decrease the expression of HIF-1a and VEGF mRNA in K562 cells., activation of PPARalpha suppresses hypoxia-induced HIF-1alpha signaling in cancer cells, providing novel insight into the anticancer properties of PPARalpha agonists., Systematic approach to the current literature on immunohistochemistry evaluation of HIF-1alpha expression in endometrial carcinoma. Review., Our data identified HIF-1alpha as a regulator of CD44 that increased the number of CD44 molecules and the percentage of CD44 positive cells expressing variant exons v6 and v7/8 in breast cancer cells under hypoxic conditions., increased expression correlated to expression of progranulin protein in villous trophoblast cells in cases of preeclampsia and fetal growth restriction, PHD2-mediated hydroxylation of HIF-1alpha predominantly occurs in the cell nucleus and is dependent on very dynamic subcellular trafficking of PHD2., The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports., results suggest that HIF-1alpha acts as an important transcription factor and can significantly affect the secretion and adhesion functions of leukemia bone marrow stromal cells., results showed that ESM-1 is significantly overexpressed, which is regulated by HIF-1alpha in colorectal cancer (CRC) patients, and can be used as a potential biomarker and a therapeutic target for CRC, Hypoxia-inducible factor-1alpha regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene, synergetic pathways of IL-17A and hypoxia might contribute to the migration and invasion of rheumatoid arthritis synoviocytes by up regulating the expression of MMP2 and MMP9 by activation of the NF-kappaB/HIF-1alpha pathway, HIF-1alpha up-regulation is dependent on intracrine PGE2-RARbeta signalling., The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells., Nitric oxide and reactive oxygen species produced endogenously by human colon carcinoma HCT116 cells are responsible for HIF-1A accumulation in hypoxia., this study unveiled a signaling axis of HIF-1alpha/miRNA-210/iron-sulfur cluster scaffold protein in a subset of head and neck paragangliomas that could have an impact on SDHB protein stability by a mechanism independent of succinate dehydrogenase mutations, HIF-1alpha may be helpful marker in evaluation of upper tract urothelial carcinoma , espec-ially when combined with angiogenesis and apoptosis., HIF-1alpha mediates prostate enlargement under inflammatory conditions., The current study demonstrates that HIF1A Pro582Ser polymorphism has an effect on DN, possibly by conferring a relative resistance to the repressive effect of glucose on HIF-1alpha., hypoxia downregulates the expression of cell surface MICA without increasing the level of soluble MICA in a HIF-1alpha-dependent manner., The results obtained show that, like DFO, apo-LF performs as a normoxic mimetic of hypoxia, capable of stabilizing HIF-1alpha., HIF-1alpha expression was low in classic, but high in pleomorphic lobular breast cancers, These data demonstrate that up-regulation of the anti-apoptotic protein Bcl-xL in NHL cells correlates with HIF-1alpha expression and activity, through which a phenotype of chemoresistance is induced., The results confirm the significant association between HIF-1alpha and VEGF expression and suggest that HIF-1alpha expression is a favorable prognostic factor in patients with DLBCL treated with rituximab., hypoxia may increase CXCR4 activity in gastric cancer cells by activating HIF-1alpha, thereby resulting in increased migratory ability, HIF-1alpha expression can be used as a prognostic marker and predictor of postoperative radiotherapy response., HIF1A was expressed in NSCLC in lung tissue from uranium miners but less in small cell lung cancer., Hypoxia induced adipogenic or asteogenic differentiation of human mesenchymal stromal cells is dependent on HIF1-alpha., Decreasing expressions of HIF-1alpha, Bcl-2 and Ki-67 were observed during chemoradiotherapy of recel cancer, whereas GLUT-1 overall was unchanged., Data suggest that, in preeclampsia, HIF1a is overexpressed in placenta which results in upregulation of sFLT-1 (soluble vascular endothelial growth factor receptor-1), sENG (soluble endoglin), and endothelin-1. [REVIEW], There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia, HIF-1 expression in hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve axons., combined variant genotypes of rs2057482 and rs11549467 were associated with increased prostate cencer risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles)., data strongly support an important role of the vascular endothelium in determining whole-organ glucose metabolism and indicate that HIF-1alpha is a critical mediator of this function, Hard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1alpha, HMOX1, and p53 activation in human peripheral blood mononucleated cells., Our data do not support the use of HIF-1alpha determined during treatment as a biomarker to predict outcome after fractionated irradiation., High mRNA expression of HIF1-alpha is associated with non-small-cell lung cancer., Hypoxia-inducible factor 1 alpha downregulates the expression of miR-17 and miR-20a that reduced c-Myc expression., Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways, Metabolic features of renal cancer are linked to VHL loss. VHL loss and the ensuing increase in the expression of hypoxia-inducible factor affect several metabolic pathways, including glycolysis and oxidative phosphorylation. [Review Article], Our results demonstrate that low dose CoCl2may protect cells against irradiative harm by two mechanisms, namely HIF-1alpha expression and ROS clearance., This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541-1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer., Lactate, the end-product of glycolysis, inhibits prolylhydroxylase 2 activity and activates HIF-1 in normoxic oxidative tumor cells but not in Warburg-phenotype tumor cells., The hypoxia response element site at -65 in the MUC5AC promoter and the HIF-1alpha are the major regulators for the cellular response against hypoxia in human bronchial epithelial cells., Hypoxia-inducible factor 1 gene expression is a key indicator of tumor progression in patients diagnosed with squamous cell laryngeal cancer., After exposure to hypoxia, HIF-1alpha protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1alpha mRNA showed no significant change, all skin biopsies from scleroderma patients were strongly HIF-1alpha reactive, compared with rare immunoreactivity observed in normal skin., The membrane permeable Fe2+-specific chelators could enhance HIF-1alpha accumulation by proline hydroxylase 2 inhibition., This report is the first study demonstrating that HIF-1alpha-mediated SP1 expression regulates PrPc transcription, and upregulation of SP1 induced by HIF-1alpha plays a key role in protection from prion-mediated neurotoxicity., Role for HIF-1alpha in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells., hypoxia and stabilization of HIF-1alpha result in up-regulation of differentiated embryo chondrocyte-expressed gene 1, loss of MiTF, and absence of MiTF binding to the IL-8 promoter, which in turn leads to up-regulation of IL-8 gene expression., Data indicate that hypoxia-induced reactive oxygen species affect hypoxia inducible factor-1 alpha stabilization., Data indicate that inhibition of Nox4 expression inhibited the transcriptional activity of VEGF through HIF-1., Transfection of cDNA expressing stable form of HIF-1alpha reversed the increased TfR1 expression and iron uptake. These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1, HIF-1alpha's role in tumorigenesis, High HIF1alpha is associated with melanoma growth., Report down-regulation of HIF-1a within sarcoid granulomas., these findings show for the first time a direct link between TG2, NF-kappaB, and HIF-1alpha, demonstrating TG2's important role in cancer progression., The hypoxia-mediated HIF-1alpha-dependent up-regulation of NRP-1 is a critical molecular event involved in the vasculogenic mimicry and tumor formation by fibrosarcoma cells in vivo., data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, Knockdown of E2F1 stabilized HIF-1alpha and promoted LOX expression, while knockdown of both E2F1 and HIF-1alpha prevented the up-regulation of LOX, delta-catenin overexpression in prostate cancer CWR22Rv-1 cells results in increased HIF-1alpha and VEGF expression, These results show that Kaposi's sarcoma-associated herpesvirus ORF34 binds to HIF-1alpha, leading to its degradation via the proteasome-dependent pathway., Our study provides evidence for the association between the HIF1A gene Pro582Ser polymorphism and elite strength athlete status., HIF-1alpha overexpression indicated unfavourable prognosis and could serve as an additional prognostic factor in neuroendocrine breast cancer., High expression of hypoxia-inducible factor 1 alpha is associated with nasopharyngeal carcinoma., The results revealed c-Myc-dependent regulation of HIF-1alpha instead of HIF-1alpha-dependent c-Myc regulation for the first time., pY654-beta-catenin is a critical co-factor in hypoxia-inducible factor-1alpha signaling and tumor responses to hypoxia.pY654-beta-catenin accumulates and associates with HIF1alpha and Src in human lung adenocarcinomas., Data indicate there was a HIF-1alpha-dependent cancer stem cell (CSC) increase in ER-alpha-positive cancers following hypoxic exposure., Our results showed that a combination of hypoxic markers is more robust than a single marker for predicting survival in high-grade glioma., The degree of hypoxia as measured by HIF-1alpha expression does not differ between HPV positive and HPV negative cancers. The role of hypoxia in HPV negative oropharyngeal cancer warrants further investigation, High expression of HIF-1 is associated with squamous cell carcinoma of head and neck., Data show that clear cell renal cell carcinoma (ccRCC) tissue and malignant cell lines expressed higher levels of CD74 and hypoxia inducible factor 1alpha (HIF-1alpha) than adjacent normal renal tissue and normal cell HK-2., Atypical osteoclast HIF-driven metabolic pathway may be an adaptive mechanism to permit rapid bone resorption in the short term while ensuring curtailment of the process in the absence of re-oxygenation., A combined effect of sorafenib and radiation in response to hypoxia was shown by inhibiting angiogenesis and metastasis by suppression of HIF-1alpha expression., Data indicate an increase of VEGF, HIF-1alpha expression and microvessel density (MVD) in BRCA1-2 carriers and BRCAX compared to the sporadic control group., findings unraveled a novel mechanism by which YY1 inhibition disrupts hypoxia-stimulated HIF-1alpha stabilization in a p53-independent manner, Upregulation of HIF-1alpha appears to be a significant mechanism of resistance to antiangiogenic therapies in neuroblastoma., altered expression of HIF-1 and its target genes may be associated with the pathophysiology of depression, suggest that HIF-1alpha polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP, Hypoxia provides two mechanisms of chondroprotection in human cartilage, A model in which the sustained synthesis of VEGF in lens epithelial cells, maintained under hypoxic condition, is regulated by a compensatory inter-relationship between HIF-1alpha and HIF-2alpha, Expression of HIF-1alpha is a predictor of tumor response to neoadjuvant chemotherapy and outcome in osteosarcoma and is correlated with VEGF, APE1, and COX-2 expression., MUC1-shRNA could inhibit proliferation and significantly weaken HIF-1alpha protein expression of QBC939 cells, suggesting its potential as a therapeutic target of CCA., HIF1alpha is likely to contribute to metastasis and chemo-resistance of CRPC and targeted reduction of HIF1alpha may increase the responsiveness of CRPCs to chemotherapy., HIF-1alpha suppression in MM cells significantly blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo., It involved in the same cascade of the malignant progression of gliomas., Pro-EMT effect of beta-catenin in hypoxia was deprived in the absence of hif-1alpha., The study of this study suggesting that impaired cytoplasmic-nuclear transport of HIF-1alpha through the nuclear pore might precede motor neuron degeneration., Peroxisome proliferator activated receptor-alpha/hypoxia inducible factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells., HIF-1alpha could be an important factor in the onset and progression of cervical cancer and an attractive therapeutic molecular target for it., Kaplan-Meier survival analysis demonstrated that HIF-1alpha and HIF-2alpha expressions were related to shortened overall survival in small cell lung cancer, Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms., TCTP binds to the beta domain of VHL through competition with HIF1alpha, which promotes VHL degradation by the ubiquitin-proteasome system and HIF1alpha stability., Elevated miR-210 expression increased survival rates along with Akt and ERK activity in human mesenchymal stem cells with hypoxia., study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis, providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1alpha pathways, a novel role for P-bodies in regulating HIF1A mRNA stability, Knockdown of Nrf2 impaired HIF1alpha signaling activation. Blockage of the FSH-ROS-Nrf2-HIF1a signaling pathway attenuated FSH-induced binding of HIF1a to the VEGF promoter., HIF-1alpha inhibited firing of replication origins, decreased DNA replication, and induced cell cycle arrest in various cell types, BRCA1 and BRCA2 germline mutation-related DCIS show a high frequency of overexpression of HIF-1alpha., Hypoxia-induced expression of TF in human breast cancer cells depends on Egr-1 and HIF-1alpha, and both of these proteins may play an important role in breast cancer metastasis, either directly or indirectly through the TF pathway., The data of this study indicated that NSPCs have a relatively low requirement for oxidative metabolism for their survival and that hypoxic resistance is not dependent upon HIF-1alpha signaling., p23 recruits PHD2 to the HSP90 machinery to facilitate HIF-1alpha hydroxylation, HIF1A 1772T allele enhances the Abdominal Aortic Aneurysm risk determined by smoking and promotes the development of a more complex phenotype of the disease in smokers (with coexisting severe peripheral arterial disease)., Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts., DEC1 level was positively correlated with HIF-1alpha and Ki67 expression in gastric cancer., In addition to HIF-1 regulating miR-210 in renal cancer, HIF-2 can regulate this microRNA in the absence of HIF-1., Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia., these findings support a novel model for HIF regulation in an in vitro model of human ischemia., Chaperone-mediated autophagy targets hypoxia-inducible factor-1alpha (HIF-1alpha) for lysosomal degradation., Serum levels of VEGF, HIF-1alpha and IGF-I were significantly higher in the diabetic patients than in the controls., critical for constitutive expression of beta-Defensins in intestines, HIF-1alpha may be a dominant factor driving the metastatic progression of pancreatic cancer and can be a potent therapeutic target for the disease., Exposure of proliferative melanoma cells to hypoxic microenvironments is sufficient, in a HIF1alpha-dependent manner, to downregulate melanocytic marker expression and increase their invasive potential., our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion, Triple point-mutants HIF1alpha effectively promoted in vivo angiogenesis in bone defect regions, HIF-1alpha is downregulated in the myocardium of transgenic-dominant-negative NADPH oxidase transgenic mice., This study demonstrated a correlation between intensity of HIF-1a expression and degree of renal interstitial fibrosis., Rac1, HIF-1alpha, and VEGF play an important role in tumor invasion and metastasis, especially in tumor angiogenesis., Knockdown of HIF-2alpha and HIF-1alpha mRNA in pulmonary vascular endothelial cells decreased cell proliferation under normoxic as well as hypoxic conditions., Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular carcinoma., In both normoxia and hypoxia, pulmonary artery smooth muscle HIF-1alpha maintains low pulmonary vascular tone by decreasing myosin light chain phosphorylation., the expression of HIF-1alpha is closely correlated with IL-6 expression (r = 0.61 and p = 0.005), suggesting a close interaction of HIF-1alpha and IL-6 in the psoriasis immuno-microenvironment., Whereas overexpression of HIF-1alpha in MSCs was protective against cell death and apoptosis triggered by hypoxic and oxidative stress conditions, its downregulation increased apoptosis and death rate., Nickel- and PGE2-stimulated release of IL-8 from human lung fibroblasts is mediated by HIF1A., HIF-1alpha up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells., HIF-1alpha and HO-1 levels in elderly patients undergoing non-cardiac surgery were significantly higher in the group with postoperative adverse cardiac events at each time point., In vitro mast cell differentiation was associated with decreased CD34 expression and increased HIF1A expression., findings reveal a negative feedback loop between CCN2 and HIF-1alpha in NP cells and demonstrate a role for CCN2 in maintaining matrix homeostasis in this tissue., Review of the biology of regulation of HIF-1alpha, its physiological and physiopathological effects; potential diagnosis and the prognosis significance of HIF-1alpha evaluated in recent studies is also discussed., our data show for the first time that glucose availability significantly affects the hypoxia-induced HIF-1/BNIP3 response, and in particular glucose absence results in enhancing the oxidative phosphorylation rate., HIF-1alpha-dependent regulation of HIF-1beta is demonstrated under hypoxic conditions, when HIF-1beta is rapidly elevated on protein level., RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2, our study demonstrates that the hypoxia-HIF-1a, LOX-FAK/AKT pathway regulates the migration and invasion of epithelial ovarian cancer cells, Prolidase dependent HIF1A expression in breast cancer cells is induced by prolidase substrate peptides., HIF-1 expression is associated with the development and progression of both astrocytic tumors and meningiomas., Melatonin as a blocker of HIF-1alpha activation could play a potential role in preventing the invasion and migration of glioblastoma cells under hypoxic conditions., HIF1alpha and PKCbeta have roles in mediating the effect of oxygen and glucose during wound healing, HIF1alpha and HIF2alpha activate independent transcriptional programs through SRC that promote metastasis by coordinately regulating cell invasion and ECM remodeling, CCN2 in the intervertebral disc is regulated by TGF-beta and hypoxia via HIF-1alpha, the critical determinants that characterize the disc microenvironment in health and disease. (Review), High expression of HIF1A positively correlates with tumor diameter, depth of invasion, and stage in gastric carcinoma, Downregulation of GRIM-19 promotes HIF1alpha synthesis., The present finding further enriched and supported the role of HIF-1alpha expression on cell apoptosis of hepatoma cells., 1790 G/A polymorphism in the PASD8 gene played an important role in the development of cancers. [Meta-analysis], mRNA of HIF-1alpha was increased by HSA treatment. In conclusion, albumin loading induces HIF-1alpha in HK-2 cells, resulting in the increases in the expression of proteins of its target genes, Correlation between HIF2A and HIF1A expression and gadobutrol dynamic contrast-enhanced magnetic resonance imaging parameters Ktrans and kep in prostate cancer., These results suggest that HIF-1alpha itself is not oncogenic but it may play an important role in lymphomagenesis., miR-199b expression level was decreased in prostate cancer while HIF-1alpha was significantly over-expressed. miR199b negatively regulated HIF-1alpha by targeting its 3'-untranslated region., Studies suggest that hypoxia, HIF-1 alpha, PHD3 and pVHL could be considered as potential therapeutic targets for lung cancer pathogenesis and progression., Data indicate that both stabilization of HIF-1alpha expression under nomoxia caused by pVHL deficiency and hypoxia treatment significantly reduced SOD2 expression., Through downregulation of the nuclear transcription factors, hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappa B (NF-kappaB)., Data indicate that menadione (MD) and ethacrynic acid (EA) decrease expression of luciferase under the control of hypoxia-responsive elements in hypoxic cells as well as to efficiently block the interaction between the full-length HIF-1alpha and p300., TGF-beta1 up-regulates STAT3 activation and HIF-1alpha stabilization, which leads to TWIST1 expression in a prostate cancer invasion cascade, The present study suggests an important role of HIF-1alpha in UVB-mediated immune response in keratinocytes., hypoxia and HIF-1alpha may function in conjunction with toll-like receptor-stimulated innate immune responses to drive inflammation in rheumatoid arthritis, Data suggest that Keap1 does not contribute to hypoxic Nrf2 suppression, and both HIF-1alpha and Siah2 are key regulators of hypoxic responses., Staphylococcus aureus infection activates HIF-1 and causes HIF-1-dependent gene programming., HIF1-alpha and CD34 are expressed differently in esophageal squamous cell carcinoma and adenocarcinoma, suggesting different mechanisms, Suggest oxLDL as a proangiogenic agent linking hyperlipidemia, inflammation, and angiogenesis in atherosclerosis via HIF-1alpha pathway., HIF-1alpha promotes cap-dependent translation of selective mRNAs through up-regulating eIF4E1, which contributes to tumorsphere growth of breast cancer cells at hypoxia, CREB acts as a platform for assembling coactivators and chromatin remodelers required for MHC-I activation in a HIF-1alpha/beta-catenin-dependent manner., The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth., Studied the usefulness of (18)F-fluorodeoxyglucose FDG-PET/CT and the relationships among the expressions of HIF-1alpha, Glut-1 and VEGF, histological type, other clinical factors and FDG uptake in thymic epithelial tumours., Natural fungal bioactive compound chaetoglobosin K effectively inhibits angiogenesis through downregulation of vascular epithelial growth factor (VEGF)-binding HIF-1alpha., hypoxia upregulated Epac1 through HIF-1alpha induction in the CD34-immunosorted human umbilical cord blood hematopoietic stem cells, Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha., Multiple HIF1alpha isoforms exist in peripheral blood mononuclear cells but no differences in expression were seen in rheumatoid arthritis compared with healthy controls., Our results reveal how TRAF6 functions to upregulate HIF-1alpha expression and promote tumor angiogenesis., The HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian populations, while the A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer. [Meta-analysis], acute hypoxic exposure for up to 60 min does not induce a generalized inflammatory response, but does induce the expression of HIF-1a and VEGF, Data indicate the role of osteopontin (OPN) under hypoxia and in breast tumor growth and angiogenesis through NF-kappaB-mediated HIF1alpha-dependent vascular endothelial growth factor (VEGF) expression., HIF-1alpha knockdown by miRNA decreases survivin expression and inhibits A549 cell growth in vitro and in vivo., HIF-1alpha is a general regulator controlling the metabolic fate and multipotency of the human mesenchymal stem cells., Study reports that HIF1A employs a specific variant of the Mediator complex to stimulate RNAPII elongation; the Mediator-associated kinase CDK8, but not the paralog CDK19, is required for induction of many HIF1A target genes., Report a new pathway of glioma radioresistance via Report the regulation of radiation-induced centrosome duplication and therefore mitotic cell death by ILK, HIF-1alpha and survivin., Overexpression of hypoxia inducible factor-1 alpha is assiciated with recurrence after curative resection of colorectal liver metastases, there were no significant differences in genotypic frequencies for P582S and A588T between breast cancer patients and controls, nor between transcriptional activity of the 582S mutant and wild-type HIF-1alpha; concluded there is no association between HIF-1alpha polymrphisms and incidence of breast cancer in the Portuguese examined population, Knockdown of Sirt7 led to an increase in HIF-1alpha and HIF-2alpha protein levels and an increase in HIF-1 and HIF-2 transcriptional activity., Through the induction of the expression of its target genes, HIF-1 coordinately regulates tissue O2 supply and energetic metabolism, Mitochondrial biogenesis is only indirectly regulated by p53, whose activation triggers a murine double minute 2 (MDM2)-mediated hypoxia-inducible factor 1 alpha degradation., No difference was observed in terms of VEGF, PIGF and HIF-1alpha in a comparison of the early- and late-onset pre-eclampsia groups., Combined detection of VM, HIF-lalpha and E-cad plays an important role in predicting the invasion, metastasis and prognosis of patients with ESCC., Upregulation and maintenance of HIF-1alpha and NGF expression may attenuate VCI., The increased expression of FGFR3 in bladder cancer was primarily dependent on HIF-1alpha, as knockdown of this isoform of the alpha-subunit had a stronger effect on suppressing FGFR3 levels in hypoxia., Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha., PHD2 regulates and hydroxylates HIF-1alpha by binding to its C-terminal domain., results provided a mechanism for communication from mitochondria to the nucleus through AMPK-HIF-1alpha., HIF1 has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells, HIF-1alpha overexpression indicates a poor prognosis for patients with hepatocellular carcinoma. [Meta-analysis], PAK1 stimulates colorectal cancer cell survival by up-regulation of HIF-1alpha., vaccinia virus (VACV) infection leads to a rapid stabilization of hypoxia-inducible factor (HIF)-1alpha, its translocation into the nucleus and the activation of HIF-responsive genes, HIF-1alpha overexpression increased VEGF and STAT-3 expression. This was inhibited by ganetespib. HIF-1alpha knockdown inhibited VEGF and STAT-3 expression., HIF-1alpha and HIF-2alpha activate CD133 promoter through ETS proteins., Elevated expression of HIF-1alpha was found in peri-implant tissues and synovial fluid of people with failing Metal-on-Metal hips., HIF-1alpha silenced BCC were less responsive to changes in OT., Hypoxia caused marked expression of HIF-1alpha in hepatoma cell lines., HIF1A polymorphisms are associated with tumor size and lymph node involvement. [Meta-analysis], This review explores the N-methyl-D-aspartate receptor and HIF1A interaction and the hypoxia connection. [review], HKII is induced by HIF-1alpha and plays important roles in the proliferation and/or progression of breast carcinoma possibly through increased glycolytic activity., Overexpression of HIF-1alpha promote the proliferation, migration and differentiation of endogenous neural stem cells after intracerebral hemorrhage., Our results show the mechanism for the cytological origin of neoplastic stromal cells in hemangioblastomas, and suggest that inhibition of the HIF pathway is an attractive strategy for the treatment of hemangioblastomas., Inactivation of HIF-1, by silencing its inducible alpha subunit, significantly decreases mTOR S2448 phosphorylation caused by ligand-dependent activation of human myeloid leukemia cells., Co-transfection of HIF-1alpha siRNA and HIF-2alpha siRNA augmented downregulation of VEGF mRNA and protein in hypoxic retinal pigment epithelial cells., Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1alpha-MUC1 pathway., the ubiquitin ligase STUB1 is required for degradation of HIF1A in the lysosome by chaperone-mediated autophagy., These results identify KLF5 as a transactivator of HIF-1alpha and show that LPA regulates HIF-1alpha by dynamically modulating its interaction with KLF5 and p53., overexpression of HIF1A is associated with metastatic clear-cell renal cell carcinoma., Elevations of HIF-1alpha expression are associated with non-small cell lung cancer., High HIF1A expression is associated with non-small cell lung cancer., Increase of serum HIF-1alpha is associated with response to therapy in non- small cell lung cancer., PHD-3 mediates specific HIF1-alpha proline 567 hydroxylation, which can function as a new player in the VHL/HIF-1alpha interactions., Data indicate that transient knockdown of BRG1 or BRM reduces hypoxia induction of several known HIF1 and HIF2 target genes in Hep3B cells., Angiogenic factors VEGF, HIF-1alpha and CD34 are important in breast cancer progression and their abundance in breast tumors has prognostic and predictive value., HIF-1alpha-induced beta-catenin activation prevented the PrP (106-126)-induced mitochondrial damage under hypoxic conditions., data indicate that HIF-1alpha controls sarcoma metastasis through PLOD2-dependent collagen modification and organization in primary tumors., Data indicate that transfection of HeLa cells with miR-17 and miR-20a led to an inhibition of Hif-1alpha and Hif-2alpha mRNA and protein expression and a lowered Hif DNA binding activity., Results indicate that thioredoxin 1 is not essential for HIF-1alpha hypoxic stabilization or activity, that its overexpression can increase HIF-1alpha hypoxic activity, and that this effect is observed regardless of thioredoxin reductase 1 status., Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha target in regulating cell survival during hypoxia., Overexpression of a HIF-1alpha mutant conferred resistance to cetuximab-induced G1 phase cell-cycle arrest, which could be overcome by knockdown of LDH-A expression., The transcription of cancer-specific OATP1B3 is regulated during hypoxia through a commonly utilized pathway involving HIF-1alpha., HIF-1 alpha protein is involved in transcriptional regulation of AURKA expression in breast cancer cell lines under hypoxic conditions., Ex vivo expansion protocols involving hypoxic preconditioning inhibit cell senescence in endothelial progenitor cells by hypoxia-induced hypoxia-inducible factor-1alpha-TWIST-p21 axis., TPL is able to enhance drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1alpha and Nrf2., Data suggest that overexpression of HIF-1alpha, GLUT-1, and iNOS may play an important role in gastric cancer progression. GLUT-1 is a potential candidate for predicting patient survival., MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1alpha in osteoblasts., Signaling interaction with TGF-beta promotes renal fibrogenesis in normoxia, HIF-1alpha/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts., Aberrant DLL4 expression and HIF-1alpha/VEGF angiogenesis signaling may have a role in missed abortion., HIF-1 and HIF-2 specific gene activating functions respond differently to different stimuli., the practical relevance of NF-kappaB and HIF-1alpha expression as prognostic indicators and potential targets for specific therapies deserve further investigation., Data indicate that patients with diabetic eye disease shows that HIF-1alpha and ANGPTL4 localize to ischemic Muller cells., Aurora A might be a key regulator of HIF-1alpha-promoting malignant phenotypes of hepatocellular carcinoma., we explored how these HIF-specific hydroxylases contribute to the HIF-1alpha-p300 interaction by FRET measurements along with HIF-1 mediated transcriptional activation, Hypoxia-inducible factor-1alpha and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis., High HIF-1alpha is associated with the development of peritoneal dissemination via natural metastatic routes in scirrhous gastric cancer, These results suggest an HIF-1alpha-dependent regulation of MGMT expression in human pituitary adenoma cells, and HIF-1a knockdown or the HIF-1a inhibitor 2ME can confer TMZ sensitization in human pituitary adenomas., HIF-1alpha and Snail are responsible for hypoxia-induced metastasis phenotypes in pancreatic cancer., HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart--{REVIEW}, RNA Pol II on HIF1 or HIF2 target genes is primarily associated with HIF1alpha or HIF2alpha in a STAT3 or USF2 dependent manner, study suggested that HIF-1alpha 1790 A > G polymorphisms may be used as a molecular marker to determine the susceptibility and severity of LDD, High HIF1A expression is associated with gastric tumors., Both the VEGFR2 receptor and HIF-1alpha were expressed in alpha-SMA positive myofibroblast-rich nodules with characteristics of Dupuytren's disease in the active involutional phase., HIF-1 is activated in cancer cells by tumor suppressor loss of function and oncogene gain of function and mediates metabolic alterations that drive cancer progression and resistance to therapy. [Review], HIF-1alpha was found directly bound to two hypoxia-response elements (HRE) of QSOX1 gene, both of which were required for HIF-1 induced QSOX1 expression., The HIF-1alpha C1772T polymorphism T allele may increase the risk of cancer metastasis. [Meta-analysis], There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha., Decorin may interfere with angiogenesis by downregulating hypoxia-induced Met, Rac1, HIF-1alpha and VEGF expression in RPE cells, which suggests a potential strategy for the inhibition of CNV., HIF1A expresion was greater in small cell and squamous cell lung cancer than in non-small cell lung cancer and lung adenocarcinoma. HIF1A expression was greater in lung neoplasms than in normal lung tissue.[Review and Meta-Analysis], downregulation of miR-199a is essential for hypoxia-induced proliferation through derepressing the expression of HIF1a expression and affecting HIF1a mediated glycolytic pathway in non-small cell lung cancer progression., At diagnosis, HIF-1alpha protein expression was absent in 8 out of 16 NHL patients. HIF-1alpha expression was detectable in all patients with advanced stage at recurrence. HIF-1alpha may have a role in the modifications of angiogenesis during lymphoma progression., the Mdm2-HIF1alpha axis is antagonized by serdementan, which decreases levels of glycolytic enzymes, transcriptional associations with HIF-1alpha and NF-kappaB, as well as beta-catenin/p300 complexes, may contribute to modulation of changes in tumor cell kinetics in response to a hypoxic condition in endometrial carcinoma cells, we conducted comprehensive search with the aim to provide an overview of studies focusing on the relationship between HIF-1a polymorphisms and cancer risk., expression of the ISG15 and/or ISGylation system attenuates HIF-1alpha-mediated gene expression and tumorigenic growth., High HIF-1alpha expression was significantly correlated with poor overall survival (OS) of gastric cancer patients., This study showed that overexpressed HIFs were significantly associated with increase of mortality risk. Subgroup analysis revealed that overexpressed HIF-1alpha was significantly associated with worse prognosis of HNC in Asian countries. [review], The current meta-analysis suggests that the C variant of HIF-1alpha C1772T polymorphism may increase the risk of GIT cancer, especially among Asian populations., SEPT9 isoform 1 is required for the association between HIF-1alpha and importin-alpha to promote efficient nuclear translocation., Hif-1alpha stabilization drives the mesenchymal stem cells towards undifferentiated state while inhibiting osteogenic and adipogenic differentiation., up-regulated expression of HIF-1alpha protein is associated with increased multidrug resistance in laryngeal carcinoma., stabilization of hypoxia-inducible factor 1A (HIF1A) during stretch conditions in vitro or during ventilator-induced acute lung injury in vivo occurs under normoxic conditions., The expression of LDH-5 and hypoxia-inducible factor (HIF) 1alpha in Non-Hodgkin's lymphoma, was examined., We conclude that functional polymorphisms in the HIF-1alpha gene do not modify CAD risk but they are associated with the formation of coronary collaterals and clinical presentation of CAD, Data indicate that the hypoxia inducible factor 1 alpha (HIF1a) +1772 genetic polymorphism predicts a more aggressive prostate cancer behaviour, suggesting the involvement of progression and androgen deprivation therapy (ADT) resistance., Ascofuranone inhibits epidermal growth factor induced HIF-1alpha protein expression in MDA-MB-231 cells., Autophagy induced by HIF1alpha overexpression supports trophoblast invasion by supplying cellular energy., The efficacy of inhibiting HIF-1alpha and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials., when HIF-1 was activated by gene introduction or chemically, CEMP1 expression and mineralization increased., These findings show for the first time that the HIF-1alpha(Pro-582-Ser) polymorphism significantly affects red blood cell and iron homeostasis after blood loss, conferring to male carriers a resistance to anaemia., the findings suggest that the early induction of HIF1alpha targets may be instrumental in iPSC derivation via the activation of a glycolytic program. These findings implicate the HIF1alpha pathway as an enabling regulator of cellular reprogramming., Our results suggest that overexpression of HIF-1alpha affects the levels of FoxP3 in Mycosis fungoides, Pharmacological inhibition of prolyl hydroxylases inhibition induces HIF-1alpha-dependent cytoskeletal remodeling in endothelial cells, which is mediated essentially by a reduction in Rac-1 signaling., Data indicate the mechanism of cross talk between the protumorigenic membrane protease MT1-MMP and the signal integrator mTOR to activate HIF-1 during normoxia., HIF-1alpha expression in vulvar carcinomas was a statistically independent prognostic factor., Acute hypoxia initially stabilizes both HIF1alpha and HIF2alpha subunits by inhibiting the HIF-prolylhydroxylase-mediated degradation of HIF proteins., A phospho-mimetic construct of HIF-1alpha at Ser668 (S668E) is significantly more stable under both normoxic and hypoxic conditions, resulting in enhanced transcription of HIF-1 target genes and increased tumor cell invasion and migration., rs2057482 polymorphism of in the 3 -untranslated region of HIF-1alpha contributed to the risk of cervical cancer in a Chinese population and thus may serve as a reliable predictive factor of cervical cancer., Our data show that the expression of HIF-1alpha is associated with stroma remodelling processes within Papillary thyroid carcinoma, VEGF and PlGF regulate transcription of KCC3b and KCC4 in erythroid cells via activation of HIF-1alpha, independent of hypoxia., Lentiviral delivery of shRNA is a promising therapeutic approach for targeting HIF-1alpha in glioma., polymorphisms of hypoxia-inducible factor 1A HIF1A gene is not associated with pathogenesis of systemic lupus erythematosus., IFN-gamma induced the loss of epithelial barrier function and disruption of tight junction proteins, by upregulation of HIF-1alpha expression through NF-kappaB pathway., Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha expression, blunted mRNA expression of HIF-1alpha, VEGF, and the glucose transport protein Glut-1 was also observed., Data indicate that ganetespib inhibited expression of HIF-1 target genes involved in against triple-negative breast cancers (TNBC) progression., miRNAs as key factors in a molecular pathway connecting Top1 inhibition and human HIF-1a protein regulation and activity, widening the biologic and molecular activity of camptothecin derivatives and the perspective for novel clinical interventions, Results suggest that these missense mutations in the HIF-1alpha gene are not important for the risk of developing osteonecrosis., A significantly increased cancer risk was found in both Asians and Caucasians for HIF-1alpha 1772C/T polymorphism., Our findings suggest that the HIF-1alpha A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk, HIF-1alpha and VEGF expression was dependent on the thrombus remodeling stage in cases of intravascular papillary endothelial hyperplasia., The HIF-1alpha protein in multiple myeloma endothelial cells may induce angiogenesis and resistance to bortezomib and lenalidomide., the existence of a positive feedback loop between HIF-1alpha and lincRNA-p21 that promotes glycolysis under hypoxia., coordinated RhoA-ROCK1 expression and signaling are mediated by hypoxia-inducible factors in breast cancer cells, HIF-1alpha overexpression was significantly associated with poor overall survival of colorectal cancer patients, particularly in Asian countries, while overexpression of HIF-2alpha was only associated with grade of tumor differentiation. (Meta-analysis), Experimental data revealed that inhibition of GSK3beta could increase HIF1alpha protein levels and expression of its target genes by increasing the stability of the HIF1alpha mRNA., The patients with HIF1 alpha 1772CC genotype had markedly longer overall survival and progression free survival than those carrying the HIF1 alpha 1772CT and 1772TT genotype., Upregulation of HIF-1alpha gene expression is associated with retinoblastoma., HIFa1 plays an essential role in the pathogenesis of renal cell carcinoma under normoxic conditions, through the loss of the Von Hippel-Lindau gene, JMJD5 has a role in regulating PKM2 nuclear translocation and reprogramming HIF-1alpha-mediated glucose metabolism, association between Ouabain and eIF4E not only raises the hope of using cardiac glycosides for cancer therapeutics more rational, but also offers a pharmacologic means for developing novel anti-cancer HIF-1alpha antagonists, the overall activity of HBx mutants appears to increase the expression and transcriptional activity of HIF-1alpha., Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway., Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1alpha., overexpression may play important role in the development of cutaneous squamous cell carcinoma, DDT expression mirrors MIF expression in ccRCC tumor sections with high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target of HIF1alpha and HIF2alpha., These results suggest that HIF-1a is a promising target and provide a rationale for clinical trials investigating the efficacy of the combination of topoisomerase I inhibitors and tirapazamine in hepatocellular cancers, all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2., Overexpression of miR-494 upregulated HIF-1alpha expression through activating PI3K/Akt pathway under both normoxia and hypoxia, and had protective effects against hypoxia-induced apoptosis in L02 cells., these data support a role for LT in dysregulating HIF-1alpha and thereby disrupting homeostatic responses to hypoxia, an environmental characteristic of certain tissues at baseline and/or during disseminated infection with Bacillus anthracis., the substitution of C allele with T at HIF-1alpha gene C1772T polymorphism is a risk factor of cancer, These findings highlight the importance of the hypoxia-sensing pathway and HIFs in clinical hematology., a highly positive correlation between PPARgamma expression and HIF-1alpha expression, High HIF-1alpha expression correlates with apoptosis inhibition, angiogenesis and is associated with rectal carcinoma., The association between hypoxia-inducible factor-1alpha expression and unfavorable outcome indicates the importance of using hypoxia-inducible factor-1alpha as a treatment target in hepatocellular carcinoma., USP8 maintains a basal expression of HIF1alpha and HIF transcriptional output in normoxia., The results indicate for the first time that the overexpression of beta3-endonexin can decrease hypoxic induction and activation of HIF-1alpha and can prevent hypoxic endothelial proliferation and angiogenic responses., these results indicated that the potential of specific inhibition of HDAC2 by small molecular chemicals may lead to future therapeutic agents in human renal cancer treatment., HIF-1 plays a functional role in stretch-induced increases of ADORA2B expression and pulmonary adenosine signaling in acute lung injury. It binds to a region of the ADORA2B promoter conveying stretch responsiveness., Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia., elevated extracellular concentration of ONOO- produces an upregulation of the angiogenic factors VEGF, hypoxic-inducible factor-alpha (HIF-1alpha), and BFGF in a human corneal limbal epithelial (HCLE) cell line., Results indicate that the high expression of HIF-1alpha in venous malformation (VM) vascular smooth muscle cells under hypoxic conditions could be an important factor for stimulating downstream angiogenesis in VM., Data indicate that overexpression and knockdown of hypoxia-inducible factor 1alpha (HIF-1alpha) decreased and exacerbated, respectively, palmitic acid-induced lipoapoptosis., HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker, EAF2 bound to and suppressed HIF-1alpha., In the Gal4 reporter systems, Sirt1 was found to repress HIF-1alpha activity constantly in ten cancer cell-lines but to regulate HIF-2alpha activity cell type-dependently., ERRalpha can promote the hypoxic growth adaptation of prostate cancer cells via a protective interaction with HIF-1alpha, suggesting ERRalpha as a potential therapeutic target for cancer treatment., study indicated that HIF-1alpha C1772T polymorphism was significantly associated with increased risk of malignancy development for Asians, the evaluation of HIF-1alpha, MT and SLUG expression in papillary thyroid carcinoma may be useful in predicting the risk of lymph node metastasis and high TNM stage., our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha protein, We demonstrate a mechanism by which EGF promotes prostate cancer cell progression through a ROS/STAT3/HIF-1alpha/TWIST1/N-cadherin signaling cascade, providing novel biomarkers and promising therapeutic targets for prostate cancer cell progression., Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A., HIF-1alpha gene variations are associated with the early-stage clear cell renal cell carcinoma., PRMT1 is a novel regulator of HIF-1- and HIF-2-mediated responses., Expression of HIF1A was prognostic for disease-specific survival in sporadic male breast cancers (HR, Interleukin-1beta promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting HIF-1 mediated adrenomedullin production., The role of FIH-1 in regulating the transcriptional activity of HIF1A in glioblastoma multiforme., A mechanism of aromatase inhibitor resistance may be through regulation of nonhypoxic HIF-1 target genes, such as BCRP, implicated in chemoresistance. Thus, HIF-1 should be explored further for its potential as a biomarker of and therapeutic target., showed that HIF-1alpha recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression, HIF-1alpha is associated with tumor differentiation, lymph node metastasis, and clinical stage, particularly in regard to survival in breast cancer patients., REVIEW, HIF-1alpha and HIF-2alpha are involved in hypoxia-induced lipid accumulation in hepatocytes via reducing PGC-1alpha mediated fatty acid beta-oxidation., Direct involvement of HIF-1alpha in the upregulation of PlGF expression in hypoxia through chromatin remodeling of hypoxia responsive elements sites, HIF-1A induced PIM2 expression in HepG2 cells via binding to the hypoxia-responsive elements (HREs) of the PIM2 promoter., HIF-1alpha may promote the EMT development through regulating fibrotic gene expression during I/R injury in human renal TECs, and miR-21 could be among the important regulatory pathways in the process, These results demonstrate that the transcription factor HIF-1alpha and its important gene target VEGF can be modulated by the antioxidant enzyme EcSOD., brought the first experimental evidence for the crosstalk between RET and HIF-1 that can explain the increased expression of CAIX in medullary thyroid carcinoma, Cyanidin-3-O-glucoside attenuates HIF-1alpha protein accumulation in hypoxic endothelial cells., AKT-induced uptake of [(18)F]FDG was found to be HIF-1alpha independent in breast cancer cell lines., These results provide molecular evidence showing that the activation of the HIF-1alpha and NF-kappaB loop is mechanistically linked with the chemoresistance phenotype of pancreatic cancer cells under hypoxic conditions, These results suggest that high HIF- 2alpha expression is associated with poor overall survival in patients with breast cancer, indicating that HIF-2alpha could be a valuable marker of breast cancer progression, The tumor suppressor LKB1 is a central regulator of tumor metabolism and growth control through the regulation of HIF-1alpha-dependent metabolic reprogramming., study demonstrated that LSD1 synergized with HIF1alpha (hypoxia inducible factor-1alpha) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation, under hypoxia, expression of HIF-1alpha is induced, leading to the increase of glycolysis in BxPC-3 cells possibly through upregulation of enzymes related to glycolysis; HIF-1alpha knockdown can inhibit the prolife ratio and promote apoptosis of pancreatic cancerous BxPC-3 cells, HIF-1alpha is proline-hydroxylated at both VHL binding sites (Pro402 and Pro564), was present in hypoxic regions of a wide range of tumours, tumour xenografts and in moderately hypoxic cells, Elevated serum HIF-1alpha may be involved in vascular calcification in patients with type 2 diabetes mellitus., High HIF-1A mRNA expression levels are associated with recurrence of hepatocellular carcinoma., HIF1A single nucleotide polymorphisms may have a role in prognosis of early stage non-small-cell lung cancer patients after surgery, Data suggest pancreatic cancer cells exhibiting high expression of HIF1A are gemcitabine-resistant; gemcitabine-resistant pancreatic cancer cells exhibit epithelial-mesenchymal transition (which is inhibited by blocking HIF1A with RNA interference)., Meta-analysis, Ki67 index, MVD and HIF-1 alpha index have promising prognostic value in BM and should be validated in further studies., HIF-alfa gene expression showed only a tendency in in chronic glomerulonephritis, overexpression of SRC-3 promoted glycolysis in bladder cancer cells through HIF1alpha to facilitate tumorigenesis, which may be an intriguing drug target for bladder cancer therapy., The expression of HIF-1alpha, at both mRNA and protein levels, was up-regulated in hippocampus and MTL cortex of mTLE patients compared with the control cortex., Mean expression levels of hypoxia-inducible factor-1alpha were significantly higher in the cold storage groups, and lower in the machine perfusion and kidney living-related donor groups., Results show that that nuclear CLU expression is regulated by direct binding of HIF-1alpha to hypoxia response elements sites and is epigenetically controlled by methylation of its promoter region., Fascin is a direct target gene of HIF-1a., These results reveal a PHD2-mediated mechanism through which ET-1 stabilizes HIF-1alpha and HIF-2alpha pathway thereby regulating lymphatic endothelial cell behavior and lymphangiogenesis., HIF1 and its related genes are highly expressed in recurrent craniopharyngioma., Stabilization of Snail by HIF-1alpha and TNF-alpha is required for hypoxia-induced invasion in prostate cancer cells., Serrated colorectal carcinoma as proposed to arise from serrated adenoma is characterized by upregulation of HIF1alpha., HIF-1alpha overexpression could be considered a useful independent prognostic biomarker in gastric cancer after gastrectomy., The hypoxia-HIF-1alpha-CXCR4 pathway plays a crucial role during the migration of human osteosarcoma cells, and targeting this pathway might represent a novel therapeutic strategy for patients suffering from osteosarcoma., Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor-kappaB activation in a hypoxia-inducible factor 1-alpha dependent manner., Studied a new therapeutic alternative in the treatment of multiresistant lung adenocarcinoma via siRNA-specific transfection of six crucial molecules involved in lung carcinogenesis, not elevated in pre-eclamptic trophoblasts, HIF-1alpha/PTEN/CD44v6/Survivin, as measured by immunohistochemistry, can be used to predict the prognosis and potential for invasion and metastasis in Asian patients with gastric cancer., RHBDF1 is a critical component of a molecular switch that regulates HIF1alpha stability in cancer cells in hypoxia., High HIF1A gene expression levels were associated with lymph node metastases in advanced gastric cancer., HIF1alpha and HIF2alpha are required during early stages of reprogramming, This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that indicate the predisposition to either AAA coexisting with peripheral atherosclerosis or AAA without such lesions., the relationship between breast cancer ultrasound synthesis diagnostic index (SDI) and the expression of MVD, VEGF and HIF-1alpha, endogenous HIF1alpha is detectable in exosomes and that LMP1 significantly increases levels of HIF1alpha in exosomes; exosome-mediated transfer of functional pro-metastatic factors by LMP1-positive NPC cells to surrounding tumor cells promotes cancer progression, These results suggested that,CypA, a gene downstream of HIF-1alpha, could promote the development of PDAC., Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina., High glucose-induced, ChREBP-mediated, and normoxic HIF-1alpha activation that may be partially responsible for neovascularization in both diabetic and age-related retinopathy., HIF-1alpha substantially influence human T cell-mediated immune responses by modulation of nT(reg)-suppressive function and IL-17A secretion by Th17 cells., FGF2 enhances formation of HIF-1 nuclear complexes via ERK pathway., The antagonistic effect of 15-LO1 is mediated by the Pro(564) /hydroxylation/26S proteasome system, while both the enzymatic activity and the intracellular membrane-binding function of 15-LO1 appear to contribute to HIF-1alpha suppression, Analysis of independent cohorts of patients with triple-negative breast cancer revealed a specific XBP1 gene expression signature that was highly correlated with HIF1alpha and hypoxia-driven signatures and that strongly associated with poor prognosis., SIRT2-mediated HIF-1alpha deacetylation is critical for the destablization of HIF-1alpha and the hypoxic response of tumour cells., Hif-1alpha and Hif-2alpha competitively bind to NICD., results demonstrate a regulatory relationship between DNM2, miR-199a, and HIF, with implications in cancer metastasis, nuclear HIF-1alpha was an independent prognostic parameters for progression-free survival in locally advanced rectal cancer, PML-RARalpha cooperates with HIF-1alpha to activate a pro-leukemogenic program., The purpose of this study was to investigate the co-expression patterns of transcription factor HIF-1alpha and von Hippel Lindau protein (pVHL) and heat shock proteins in pterygium and normal conjunctival human samples., Hyperthermia-conditioned olfactory ensheathing cell serum-free-conditioned medium induces neural stem cell differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity., increased expression in the nasal mucosa of patients with allergic rhinitis, Data shows that HIF-1alpha plays a central role in the acquisition of anti-apoptotic property in colon cancer cells under glucose deprivation., A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1a and HIF-2a-mediated and TSA-sensitive chromatin modification mechanisms., Results show that HIF-1 plays a major role in cancer cell angiogenesis, metabolic adaptation and metastasis. [review], HIF-1alpha is an important player in multiple myeloma homeostasis and that its inhibition by small antisense oligonucleotides provides a rationale for novel therapeutic strategy to improving MM treatment., Tan IIA ameliorated hypoxia-induced DOX resistance and EMT in breast cancer cell lines, which may be attributed to the downregulation of HIF-1alpha expression., The underlying mechanism of hypoxia-upregulated lncRNA-UCA1 expression was that HIF-1alpha specifically bound to HREs in the lncRNA-UCA1 promoter, Higher HIF-1alpha expression was associated with the higher risk of recurrence (P = 0.0434)., Data suggest expression of HIF1A in neuroblastoma can be regulated by dietary factors; supplementation with beta-carotene down-regulates expression of HIF1A in neuroblastoma, prevents neuroblastoma, and inhibits neuroblastoma invasion/metastasis., In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha expression leading to vascular abnormalities and tumor progression., Suggest that in anemia each organ expresses a different threshold for cellular HIF/NOS hypoxia responses., CCL2 expression correlates closely with HIF-1alpha expression in gastric cancer and may be an independent prognostic marker, HIF1A may regulate some of the gene expression and biological behavior of TGFbeta1 pathway-expressing melanoma cells, in part via alterations in miR-210, miR-218, miR-224, and miR-452, 5'-UTR-dependent up-regulation is dominant among metastatic cell lines (MDA-MB453, U87MG). It is therefore likely that the predominance of 5'-UTR-dependent translational enhancement of HIF1A is critical for the malignant phenotype of cancer cells., HIF1A rs2057482 polymorphism is involved in the risk of developing coronary artery disease and is associated with some metabolic parameters and cardiovascular risk factors., Study suggests that many of the morphological changes detected in children's brainstems regarding distributions of HIF-1alpha and MAP-2 could be due to age differences, but in some regions these distributions are more dependent on the hypoxic conditions, miR-210 downregulation decreased viability and induced apoptosis in hypoxic chondrocytes depending on HIF-1 alpha ., HIF-1alpha is upregulated in tumor cell lines following nicotine-induced cell proliferation., HIF-1alpha plays a major role in the survival and aggressive phenotype of retinoblastoma cells under hypoxic conditions., HIF1A critically regulates HUVEC cell proliferation and migration at 21% oxygen, but not at physiologic 3% cell oxygen., HIF-1alpha-siRNAs abrogated EGF-induced BNIP3 but not VEGF expression., Hypoxia-inducible factor has a role in promoting macrophage recruitment through signaling between triple-negative breast cancer cells and mesenchymal stem cells, HIF-1alpha expression is affected by anemia, although this factor has no important direct effect on the perinatal outcome., Data suggest that hypoxia-induced expression of BOK (Bcl-2-related ovarian killer protein) in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT)., HIF1alpha reprograms melanomas to become highly glycolytic and dependent on glycolysis for survival., besides HIF-1alpha, several other pathways, including PI3K/Akt, may be involved in the response to hypoxia of immature and, more specifically, of mature DC to sustain their trafficking and functions within hypoxic microenvironments., Inherited susceptibility to increased HIF1alpha expression resulting in the up-regulation of angiogenic genes may mediate a protective effect in normal pregnancy and pregnancy complicated by late onset preeclampsia., significant associations were found between the Hif-1/HIF-1 1790G/A polymorphism and lung cancer, pancreatic cancer and oral squamous cell carcinoma, Upregulated EPAS1 expression in hypoxic colorectal cancer cells that were associated with DNA demethylation of the EPAS1 regulatory region., HIF-1alpha can be induced and activated at physiological oxygen tensions in a MAPK-dependent manner, that determines the increased cell proliferation., Data show that the development of drug resistance described in osteosarcoma may be related to the activation of HIF-1alpha., Anoxia up-regulates MUC5AC by the HIF-1alpha signaling pathway in human nasal epithelia., This study demonstrates a novel function of HIF (HIF1a and HIF2a)in regulating RNA splicing of HIF target genes, Protein levels of HIF-1alpha were significantly increased in TACE tissues., O-GlcNAcylation regulates cancer cell metabolic reprograming and survival stress signaling via regulation of HIF-1alpha., HIF-1alpha silencing enhanced radiation therapy for gliomas in vitro and in vivo., Data indicate that zinc finger protein SNAIL modulates ribosomal protein S6 kinase 1 (RPS6KB1)/HIF-1alpha/protein kinase 2 (PKM2) signaling pathway through miR-128., knockdown of HIF-1alpha could enhance hypoxia-induced slight increase of Bax/Bcl-2 ratio and activate caspase-9 and caspase-3., Rating HIF1 polymorphism did not reveal a relationship to the occurrence of ischemic heart disease in patients with obstructive sleep apnea, both in the whole group as well as separate subgroups., Depending on the pathological context, activation of HIF-alpha and VEGF-A signaling in renal tissue/cells may have either beneficial or harmful effects., Berberine may inhibit the expression of HIF-1alpha and VEGF and thus confer radiosensitivity on prostatic cancer cells., The results suggested that the expression level of BAG3 and HIF-1 alpha is efficient prognostic parameters in patients with HCC after liver transplantation., Training-induced negative regulation of HIF mediates the attenuation of PDK-1 and contributes to skeletal muscle adaptation to exercise., HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-gp., Studies indicate that the transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of hypoxia inducible factor-1alpha (HIF-1alpha) are mainly modulated by various post-translational modifications., this study reveals that HIF-1alpha-regulated cellular metabolic processes are negatively affected by the AhR agonist PCB 126, SHARP1 interacted with HIF-1alpha physically., Rb is present in HIF1alpha-ARNT/HIF1beta transcriptional complexes associated with TRIP230 as determined by co-immuno-precipitation, GST-pull-down and ChIP assays, These findings indicate that fatty acids bound to albumin play a crucial role in albumin-induced HIF-1 activation followed by changes in HIF-1 target gene expression and protein product activity., In Chinese glioma patients the 1772C>T genotype TT had a higher risk of glioma than CC genotype or controls. Survival was lower in TT or CT genotypes. HIF-1alpha regulates the proliferation, migration and invasion of human glioma U251 cells., These results suggested that hypoxia could stimulate Foxp3 expression by increasing HIF1alpha expression in CD4(+) T lymphocytes which may promote CD4(+) T lymphocytes to convert to Treg., Bladder cancer patients with high HIF1A expression had improved 5-year local relapse-free survival with chemoradiotherapy., This result shows that unliganded ERbeta is sufficient to inhibit HIF-1 in systems of overexpression., Exposure of human breast cancer cells to hypoxia augments microvesicle (MVs) shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface., Results suggest that nerve growth factor (NGF) and hypoxia inducible factor-1alpha (HIF-1alpha) are synergically involved in the angiogenesis of non-small cell lung cancer (NSCLC)., In CLI patients a significant decrease in serum HGF levels, concomitant with a loss of skin HIF-1alpha stabilization and a lack of c-Met phosphorylation were seen, probably driving a decrease in wound-healing functions., Data show that doxazosin inhibited the phosphorylation of VEGF receptor-2 (VEGFR-2) Akt and mammalian target of rapamycin (mTOR), and hypoxia-inducible factor 1 (HIF-1alpha) expression., Rg3 exhibits anti-leukemia effect in part due to its anti-angiogenic activity via inhibiting PI3K/Akt and ERK1/2 pathways, which act to regulate the expression of HIF-1alpha and VEGF., No significant association was found between these 2 SNPs in HIF1A gene and clinical outcomes of CRC., Overexpression HIF1alpha was related with higher expressions of CXCR7 and CXCR4, otherwise IDH1 mutation related with lower expression of both genes in astrocytomas., transfecting mTOR siRNA into A549 cells significantly decreased the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and survivin, Overexpression of hypoxia-inducible factor-1alpha is associated with cervical cancer., study indicates HIF-1 not only regulates hypoxia-induced VEGF-A production but also mediates at least in part the effects of growth factors and dexamethasone on VEGF-A synthesis and release; findings show the complexity of VEGF-A regulation in meningiomas, HIF-1alpha, promotes angiogenic stimulation required for cancer development, with a resultant aggressive cell phenotype and rapid malignant progression., High expression of HIF-1alpha is associated with sinonasal and laryngeal small-cell neuroendocrine carcinoma., Ent caused HIF-1alpha protein stabilization., spermatozoa from the asthenozoospermic group presented an increased expression of IL-1beta, COX-2, and HIF-1alpha compared with the normospermic fertile subjects, HIF-1alpha-miR-21 feedback contributes to the adaptation of cardiomyocytes to hypoxia, describe a mechanism through which hypoxia and specifically HIF-1alpha preclude cells from maintaining senescence-driven anti proliferative response, Enhanced autophagy was induced by the elevated level of HIF-1alpha; metastatic ability and epithelial-to-mesenchymal transition of pancreatic cancer stem cells was associated with HIF-1alpha and autophagy. This finding may indicate the specific role of HIF-1alpha and autophagy in promoting the metastatic ability of pancreatic cancer stem cells., No associations appeared between HIF1A SNPs and age-related macular degeneration, which were studied here for the first time., HIF-1alpha may be a key factor in cell proliferation in hMSCs and important in wound healing., WWOX controls glycolytic genes' expression through hypoxia-inducible transcription factor 1alpha (HIF1alpha) regulation. WWOX, via its first WW domain, physically interacts with HIF1alpha and modulates its levels and transactivation function., Study demonstrated that high levels of EZH2 expression predicted poor prognosis in luminal-subtype breast cancer patients. Importantly, EZH2 and HIF-1alpha co-overexpression predicted poorer overall survival., Cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner., Impaired hypoxia-inducible factor regulation by hyperglycemia, the undetectable PHD3 could contribute to the higher HIF-alpha expression in ccRCC., Data show that tumor necrosis factor-alpha (TNF-alpha) increased A549 lung adenocarcinoma cell permeability by repressing vasodilator-stimulated phosphoprotein (VASP) expression through the activation of hypoxia inducible factor 1 alpha subunit (HIF-1alpha)., SNPs in HIF1a associate with MI, T2DM, hypertension, and dyslipidemia., our study provides a mechanistic insight into how TRPM8 promotes the hypoxic growth adaptation of cancer cells via its promotion of RACK1-mediated stabilization of HIF-1alpha, A novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors., Cdk1 activity blocks lysosomal degradation of HIF-1alpha and increases HIF-1alpha protein stability and transcriptional activity. By contrast, Cdk2 activity promotes lysosomal degradation of HIF-1alpha at the G1/S phase transition., Modulation of HIF1A activity by anaesthetics may affect cancer recurrence following surgery., it mediates tumor growth., SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha-dependent pathway., We found that HSF4 downregulation led to decrease of HIF1alpha mRNA expression, HIF-1 promotes the expression of its alpha-subunit via an epigenetically regulated transactivation loop., HIF-1alpha is a transcription factor for PRDX3 gene expression in clear cell renal cell carcinoma., Serum HIF-1alpha was identified as relevant baseline biomarker of Sunitinib activity in advanced Renal Cell Carcinoma., The expression of both BNIP3 and IGF-2 was completely suppressed in the HIF-1alpha deficient cells. The present study demonstrates Cu-dependent and -independent HIF-1 regulation of gene expression., We also summarized the latest findings concerning the role of HIF-1 in the development of hepatocellular carcinoma , which could shed light on new therapeutic approaches for the treatment of HCC., Pfn1 is a tumor suppressor in pancreatic cancer that acts via a novel mechanism of regulating the SIRT3-HIF1alpha axis., these data provide the first evidence of antiproliferative and apoptosis-inducing effects of IK as a HIF-1alpha inhibitor and suggest it may be a drug candidate for chemotherapy against oral cancer., Data indicate that hypoxia-inducible factor (HIF)-1alpha (HIF-1alpha) levels are raised in sera and lung tissues of chronic obstructive pulmonary disease (COPD) patients and smokers with normal lung function., irradiation reduces hydroxylation of HIF1alpha through destabilization of prolyl hydroxylases (PHD)-2 in glioma cells, We demonstrate Beclin 1-independent autophagy is involved to positively regulate nutrient deprivation induced-HIF-1alpha internal ribosome entry site activity and protein expression, our findings suggest that HIF1A Pro582Ser polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations., High expression of HIF1alpha is closely associated with the tumor size, lymph node metastasis and perineural invasion in pancreatic cancer., These findings suggest that the HIF-1alpha expressions in different cell populations of esophageal squamous cell carcinoma microenvironments have different clinical relevance and prognostic impact on patients., HIF-1alpha directly regulates Ob-R expression in pancreatic cancer, Gamma-secretase can achieve temporal control of neoplasm invasion and metastasis through conditional interactions with regulatory proteins, such as Hif-1A, under select physiological and pathological conditions., peritoneal milky spots served as a hypoxic niche and favored gastric cancer stem/progenitor cells peritoneal dissemination through hypoxia-inducible factor-1alpha both in vitro and in vivo, Laboratory findings indicate stabilisation and an increased transcription activity of hypoxia-inducible factor 1 alpha (HIF1alpha), leading to up-regulation of its downstream target genes (such as vascular endothelial growth factor (VEGF)., The HIF-1alpha G1790A polymorphism may increase the risk of colorectal, esophageal, gastric, and liver cancers, especially among Asian populations. (Meta-analysis), RBP2 promotes HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway., NF-kappaB signaling is activated in Hepatocellular carcinoma and associated with disease prognosis and with high circulating levels of HIF-1 alpha., Study demonstrated that reactive oxygen species promote the migration and metastatic growth of ovarian cancer cells via upregulation of HIF-1a and LOX and E-cadherin repression., Newly discovered S-sulfenylations suggested novel redox mechanisms, including S-sulfenyl-mediated redox regulation of the transcription factor HIF1A by SIRT6., HIF and mTORC1 signalling seems active in both Basal cell carcinoma and trichoepithelioma., HIF-1 and HIF-2 directly activate the expression of AXL and GAS6/AXL signaling uses lateral activation of the met proto-oncogene (MET) through SRC proto-oncogene nonreceptor tyrosine kinase to maximize cellular invasion., HIF-1a CG and CA haplotypes might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population, Mechanistic studies confirm the mode of action of 20(S)-Rg3, which reduces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) by activating the ubiquitin-proteasome pathway to promote HIF-1alpha degradation, Mdm2, p53 and HIF1alpha all respond to hypoxia, and intriguingly, have distinct roles depending on the level of hypoxia, Curcumin significantly decreases hypoxia-induced hypoxia inducible factor-1alpha protein level in HepG2 cells., 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating expression hypoxia-inducible factor-1 and -2., Data show that 2-deoxy-d-glucose (2-DG) combined with methylprednisolone synergistically inhibited cell proliferation, induced cell apoptosis and cell cycle arrest via down-regulation of hypoxia inducible factor 1 alpha subunit (HIF-1alpha) and c-MYC proten., Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1alpha depletion or imatinib treatment., Helicobacter pylori led to HIF-1alpha stabilization in gastric epithelial cells independently of T4SS, NF-kappaB, and MAPKs., Binge alcohol promotes acute liver injury in humans at least partly through a CYP2E1-HIF-1a-dependent apoptosis pathway., results demonstrate that multiple regulatory factors, such as impaired TLR4 surface expression, increased intracellular iron, and decreased HIF-1alpha, downregulate HO-1 expression, These results indicate that the HIF-1alpha expression is associated with hippocampal apoptosis, and suggest that HIF-1alpha is an important factor during epileptogenesis, 3 biomarkers in 44 patients with in situ breast cancers were evaluated, The interaction between MM cells and BM stromal cells is drastically reduced upon HIF-1alpha down-modulation., these results suggest that NO could regulate the expression of Tbeta4 by direct or indirect effect of HIF-1alpha on Tbeta4 promoter., Meta-analysis suggests HIF-1alpha overexpression is significantly associated with poor prognosis in pancreatic cancer., the NTR1-HIF-1alpha-VEGFalpha axis has a role in intestinal angiogenic responses and in the pathophysiology of colitis and inflammatory bowel disease, long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma., Data indicate that emodin attenuated the lipopolysaccharide and hypoxia/reoxygenation (HR)induced intestinal epithelial barrier dysfunction mediated by hypoxia-inducible factor 1, alpha subunit (HIF1alpha) and nuclear factor NFkappaappa B., HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells., Cullins are a family of NEDD8 targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A), via Cullin-2., HIF1alpha signaling appears to play an important role in epithelial-mesenchymal transition after exposure to cigarette smoke, Review/Meta-amalysis, Molecular dynamics of hif-1alpha and VHL may determine the success of antineoplastic strategies in hypoxia-reoxygenation as predicted by computational modeling., Upregulation of HIF-1alpha by hypoxia protect neuroblastoma cells from apoptosis by promoting survivin expression., Results show transcriptional upregulation of HIF1a in prostate cancer stem cells (CSC) and decreased mTOR activity leading to inhibition of proliferation and promoting survival of prostate CSCs through the IRS-1/PI3K feedback loop., Vaccinia virus C16 reprogrammes cellular energy metabolism towards increased synthesis of the metabolic precursors utilized during viral replication via the stabilization of HIF-1alpha., data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy., These observations define a novel function of PLD1 as a previously unrecognized HIF-1alpha regulator., HIF-1alpha high expression was correlated with node involvement, clinical stage and poor prognosis of nasopharyngeal carcinoma patients., PHD3 SUMOylation occurs at a cluster of four lysines at the C-terminal end of the protein. Furthermore, PHD3 SUMOylation by SUMO2 or SUMO3 contributes to PHD3-mediated repression of HIF1-dependent transcriptional activity., Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC., these findings indicate that the antitumor effect of F2 is, at least in part, mediated by suppressing HIF-1alpha-dependent pathway, and suggest that F2 may be a potentially useful agent for treatment of human cancer, Our results imply that autophagy contributes to the reduction of radiosensitivity in hypoxic environment, and the process is mediated through the HIF-1alpha/miR-210/Bcl-2 pathway in human colon cancer cells, PPARA activity increases the expression of miR-199a2 which in turn is responsible for reduced expression of HIF-1a and ET-1., The first trimester placental tissues are not energetically compromised from hypoxia; HIF-1alpha is unlikely to play an appreciable role in regulating transcriptional activity under steady-state conditions in vivo., TRPM2-L function may be a novel approach to reduce tumor growth through modulation of HIF-1/2a, mitochondrial function, and mitophagy., deregulated GAPDH expression promotes NF-kappaB-dependent induction of HIF-1alpha and has a key role in lymphoma vascularization and aggressiveness, HIF-1alpha depletion induced a reversal of the epithelial-to-mesenchymal transition in colon cancer cells., HIF-1alpha 1790G>A polymorphism is associated with the susceptibility to CSM and can be used as predictor for the clinical outcome in CSM patients receiving ACF treatment., Positive expression of SLC2A1, SLC2A3, and HIF-1alpha genes was noted in 83.9, 82.1, and 71.7% of SCC specimens and in 34.4, 59.4, and 62.5% of laryngeal cancer samples. Higher levels of mRNA/protein for GLUT1 and HIF-1alpha were noted in SCC compared to NCM, IL-1b, which normally bridges innate and adaptive immunity, induces the production of the major haematopoietic/proleukaemic growth factor SCF through the PI-3K/mTOR pathway and the HIF-1a transcription complex., Data show that dimethyl-2-ketoglutarate (DKG) inhibits hypoxia-inducible factor 1alpha (HIF-1alpha) proline hydroxylation and degradation mediated by prolyl-4-hydroxylase PHD2., HIF-1alpha is expressed in acute and chronic ischemic tissue, but also in normal colon tissue and inflammatory disorders., These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha in response to hypoxic stress and underscores the crucial role of HIF1-alpha-induced PLD2 in tumor growth., The HIF-1 alpha stabilization/nuclear translocation seemed related to HIF-1 activity upstream of E-cadherin signalling, that was regulated by Wwox/HDM2, while TAZ is known to be a co-factor of HIF-1., Hif-1Aregulates activation of hepatic stellate cell by modulating autophagy., Taken together IL-10 influences the DNA binding pattern of HIF and the level of gene induction., HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia, Tim-3 triggers growth factor type responses in acute myeloid leukaemia cells by activating a phosphatidylinositol-3 kinase (PI-3K)/mammalian target of rapamycin (mTOR) pathway., The present meta-analysis suggests that HIF-1alpha C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians., HIF1A expression may be a potential new therapy to resolve Adherent invasive E. coli infection in Crohn disease patients, This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1alpha gene likely contribute to increased cancer susceptibility., Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region., Hispidulin sensitizes tumor cells to Gemcitabine and 5-Fluoroucil by down-regulating HIF-1A/P-gp signaling., These results indicate that HIF-1alpha is required to restrain the NF-kappaB response, and thus prevents excessive and damaging pro-inflammatory responses., There is no significant association between HIF-1alpha (1772C>T) (rs 11549465) polymorphism and breast cancer development., HIF-1a levels in the serum and SF were closely related to the radiographic severity of Osteoarthritis and may serve as an alternative biomarker for the progression and prognosis of knee Osteoarthritis, Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1dependent manner., Findings show that TET1 serves as a transcription co-activator that interacts with HIF-1alpha and HIF-2alpha to enhance their transactivation activity as well as INSIG1 in addition to its role in demethylating 5-methylcytosine., HIF-1alpha polymorphisms (g.C111A, g.C1772T and g.G1790A) are not associated with breast cancer risk., High HIF1A expression is associated with drug resistance in hepatocarcinoma., The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis, Inhibition of TAp73 results in an accumulation of HIF-1alpha and up-regulation of HIF-1alpha target genes., The transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angiogenesis., Data suggest that the mechanism of gamma-H2AX on the angiogenic activity of hepatocellular carcinoma (HCC) might go through EGFR/HIF-1alpha/VEGF pathways under hypoxic conditions., PDAC specimens also showed higher expressions of PHD3 but lower expressions of HIF-1alpha, increased HMGB1 induces an extension of inflamed synovium by accelerating angiogenesis in rheumatoid arthritis through enhancement of HIF-1alpha activation., HIF-1alpha may modulate vascular mimicry in esophageal squamous cell carcinoma by regulating VE-cadherin expression., miR-429 attenuates HIF-1 activity by decreasing HIF1A message during the early stages of hypoxia before HIF-2 is activated, High HIF-1A expression predicts poor survival in clear cell renal cell carcinoma patients., review examines the role of HIF-1alpha in MM and recent developments in harnessing the therapeutic potential of HIF-1alpha inhibition in MM, For the 1772 C/T polymorphism in HIF1A, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk., GPX8 is transcriptionally regulated by HIFalpha and modulates growth factor signaling in HeLa cells., the complex structural remodeling of the matrix might reduce oxygen availability in the valve cusp contributing to the stabilization of HIF-1alpha that in turn induces a metabolic adaptation through the upregulation of VEGF, Data suggest, in pregnancies with monochorionic twins sharing one placenta and exhibiting selective intra-uterine growth restriction, expression of HIF1A mRNA (a biomarker of oxidative stress) is up-regulated in placental share of the smaller twin., Enhancement of VEGF release in long-term drug-treated breast cancer via TRPC5-HIF1A pathway, The study establishes a link between immune selection, overexpression of HIF-1alpha, and cancer immune adaptation under normoxia, HIF1alpha-ZEB1 signaling axis promotes hypoxia induced mesenchymal shift and invasion in glioblastoma cells., Our findings that reduced Beclin-1 and high HIF-1alpha expression are associated with the development and progression of HCC may provide molecular therapeutic targets toward inhibiting HCC development and progression., Report efficient delivery of HIF1alpha siRNA into tumors as part of combination therapy along with photodynamic therapy in the treatment of oral squamous cell carcinoma., Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2)., Factor inhibiting HIF1alpha (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1alpha pathway, Results indicate the impact of hypoxia on lipid metabolites, of which a distinct subset is regulated by hypoxia inducible factor 1 alpha subunit (HIF1alpha)., ING1b finely regulates the hypoxic response by triggering HIF1alpha proteasomal degradation., UCHL1 promotes metastases as a deubiquitinating enzyme for HIF-1alpha., our data suggest that RBM38 is a novel translational regulator of HIF1alpha under a hypoxic condition., HIF1alpha has a role in protecting cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia, SET9 enriches at hypoxia response elements sites of HIF-1 responsive glycolytic genes and stabilizes HIF-1alpha at these sites in hypoxia., Inhibition of HIF-1alpha might be a valuable strategy to optimize the efficacy and reduce the complication of trans-arterial chemoembolization., Taken together, these results illustrate that, as a potent inhibitor of HIF-1alpha and Stat3 signaling, LB-1 exhibits antitumor effect and could be potentially used to treat pancreatic cancer., Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway., PKM2 is an active protein kinase, and promotes liver cancer cell proliferation by up-regulating HIF-1alpha and Bcl-xL expression., Review/Meta-analysis, the nuclear entry of FIH-1 depends on HIF-1alpha, Studied the effects of zeaxanthin on the VEGF and HIF-1alpha expression in the primary culture of human RPE cells. Hypoxia caused a significant increase of VEGF expression and accumulation of HIF-1alpha in RPE cells., A meta-analysis revealed that the HIF-1alpha G polymorphism might lead to susceptibility to malignant tumors, especially in European and East Asian populations., We have discovered the CEBPD- hypoxia-inducible factor-1 (HIF-1) pathway as a new HIF-1-regulating fundamental mechanism in tubular epithelial cells for the cellular protection against kidney injury., SOCS3 negatively regulates proliferation and angiogenesis of NCI-H446 cells and that HIF-1alpha is required in this process. The results also suggested a suppressive role of SOCS3 in Akt signaling, but not STAT3 signaling to block HIF-1alpha expression, Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1a transactivity, enhancing angiogenesis and increasing new vessel formation., mRNA levels of HIF-1alpha were increased in muscle tissue of COPD patients compared to controls, which was most pronounced in the patients with high levels of muscle TNF-alpha., Suggest that HIF-1alpha and Sema4D expression correlates with histological tumor type, TNM stage, and lymphatic metastasis in colorectal carcinoma., Chromatin immunoprecipitation analysis demonstrated binding of hypoxia-inducible factor-1alpha (HIF-1alpha) to proximal hypoxia-response element (HRE) sites within the B7-H4 promoter in multiple myeloma cells and cancer cell lines., SIRT1 signaled through a hypoxia-inducible factor-1 alpha (HIF1alpha)-dependent pathway, orchestrating the reciprocal TH1 and T(reg) lineage commitment through DC-derived IL-12 and TGF-beta1., Perpared a novel biodegradable D-alpha-tocopheryl polyethylene glycol 1000 succinate-b-poly(epsilon-caprolactone-ran-glycolide) (TPGS-b-(PCL-ran-PGA)) nanoparticle to use as a delivery system for siRNA targeting HIF-1alpha in nasopharyngeal carcinoma gene therapy., expression of HIF-1alpha and CD271 in melanomas at different phases of progression, as evaluated by histology and reflectance confocal microscopy, placental expression highest at no more than 10 weeks gestational age, HIF1alpha is a regulator of monocyte functional re-programming in sepsis via regulating of IRAKM expression., These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions., Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma., miR-195 induced apoptosis in hypoxic chondrocytes by directly targeting HIF-1alpha., novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis, HIF-2alpha acts as an important negative regulator of hepatic lymphangiogenesis in vitro and in vivo by inducing IGFBP1., These findings indicate that LncRNA HIF1A-AS1 may play an important role in the pathogenesis of Cardiovascular disease , and provide a novel molecular mechanism of clopidogrel for treatment of Cardiovascular disease ., Abnormal expression of FOXP1 in renal cell carcinoma may create progression of tumor from low grade to high grade by regulating the HIF-1-VEGF pathway., Inhibition of the p38 mitogen-activated protein kinase (MAPK) reversed H2S mediated effects, suggesting that the p38 MAPK pathway may be involved in H2S induced HIF-1alpha/Nrf2 signalling pathways., Results identified SCF as a direct target of HIF-1 in pancreatic cancer. SCF/c-kit promoted invasion and proliferation of pancreatic cancer cells and may be a new target for the treatment of pancreatic cancer., Data show that SHP-1 promotes HIF-1alpha degradation under hypoxic conditions leading to a reduction in VEGF synthesis and secretion and impairing epithelial cells proliferation., Simultaneous HIF-1a and HIF-2a gene knockdown attenuates acquired radioresistance in Hela cells., Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma ., our results demonstrated that upregulation of HIF-1alpha in NB promotes proliferation, migration and invasiveness via SHH signaling., Study showed the expression of HIF-1alpha can regulate proliferation, cell cycle, apoptosis and invasion in human tongue squamous cell carcinoma., NF-kappaB both positively and negatively fine-tuned HIF-1 in hypoxic hepatocarcinoma cells., HIF-1alpha knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2+)]i., The HIF-1a gene polymorphisms might not contribute to the development of chronic hepatitis B and HBV-related liver cirrhosis in a Chinese population., Hypoxia induces changes in the gene expression of HIF-1alpha and C/EBPalpha in bladder cancer cells., HIF1alpha mediates altered tumor metabolism in clear cell renal cell carcinoma, Aberrant STAT3 and HIF1a activity drives tumor progression in malignant peripheral nerve sheath tumors., HIF-1alpha and reactive oxygen species mediate radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells., HIF-1alpha uniquely maintains basal expression of AQP1 and AQP5 in nucleus pulposus cells, RNAi targeting HIF-1alpha significantly inhibited the expression of Glut-1 mRNA., significance of NF-kappaB and HIF-1alpha and their target genes VEGF, IL-1beta, and MMP-1 in Porphyromonas gingivalis and hypoxia induced periodontal inflammatory processes., expression of HIF and GLUT proteins within TSCC appears to be associated with disease stage, grade, and the presence of metastases. Additional studies are needed to evaluate the diagnostic and prognostic uses of these proteins in the treatment of TSCC, Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor coordinating barrier protection., Data suggest expression of IGFBP1 (insulin-like growth factor binding protein 1) in hepatocytes can be regulated by carnosine, a dietary factor; carnosine down-regulates expression of IGFBP1 in Hep G2 cells; mechanism involves suppression of HIF1A., miR-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a-independent manner. Additionally, miR-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6., In vitro analysis revealed that propranolol reduces the expression of HIF-1a in hemangioma cells in a dose- and time-dependent manner, mainly by acting on b2-AR, After the silencing of HIF-1alpha, the radiosensitivity of MCF-7 cells increased and the autophagy level decreased in response to DNA damage induced by ionizing radiation, but there was no influence on IR-induced apoptosis, DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma., miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1alpha, KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation of HIF1alpha in PTEN deficient prostate tumors., HIF1 regulates claudin-1 in intestinal epithelium. This regulation is important for intestinal epithelial tight junction integrity., demonstrate that transcriptional regulation of HIF-2alpha seems to be restricted to neural cell-derived tumors, while HIF-1alpha is canonically regulated at the post-translational level uniformly across different tumor forms, Data indicate that mutant VHL can protect HIF1alpha from SART1-dependent degradation in normoxic conditions, but this protection is lost in hypoxic settings, favoring hypoxia-dependent ccRCC proliferation., Results show that HIF-1alpha potentiates BMP2-induced mesenchymal stem cells chondrogenic differentiation, inhibits osteogenic differentiation and endochondral ossification, and maintains hyaline cartilage phenotypes., Data (including data from studies in knockout mice) suggest that adherence to and invasion of urothelium by uropathogenic Escherichia coli is significantly reduced when HIF-1alpha is stabilized and allowed to accumulate in urothelium., Pre-treatment levels of HIF-1alpha were associated with negative clinical outcome in breast cancers treated with letrozole. Xenografts expressing HIF1A were resistant to fulvestrant.Inhibition o fits expression inhibited the RAS/MAPK/ERK1/2 pathway., our results demonstrate that Hif1alpha and Wnt/beta-catenin signaling pathways support leukemia stem cell function in T-cell acute lymphoblastic leukemia, HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha and HIF2alpha in binding to transcriptional elements in target genes during hypoxia. (Review), The results suggest Tip110 is an important mediator in the cross talk between p53 and HIF-1 alpha in response to hypoxic stress., Serum HIF1a was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. HIF1a increased with nephropathy severity., FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1 alpha., HIF1a may have a role in metabolic changes in type 2 diabetes, Co-expression of HIF-1a and NBS1 in primary tumors of patients with lung adenocarcinoma correlates with a worse prognosis, TM9SF4 is a direct target of HIF-1alpha, down-regulated in leukemic cells by hypoxia and involved in cell adhesion., data establish YB-1 as a critical regulator of hypoxia-inducible factor 1alpha (HIF1alpha) expression in sarcoma cells, Expression of HIH-1alpha in non-small cell lung cancer patients was related to Treg cell number and immune status., Hypoxia-induced endothelial to mesenchymal Transition is mediated by HIF1alpha through direct targeting of SNAIL., HIF-1alpha promotes radiation resistance in a cell autonomous manner, MTG16 co-repressor promotes degradation of HIF1alpha in lymphoblasts., the expression levels of HIF1a, Snail and Ecadherin were correlated with clinical pathological factors in human ovarian cancer., M410 depolymerized microtubules and downregulated HIF-1alpha protein levels in a proteasome-independent manner and reduced the mRNA of HIF-1-targeted genes in the MDA-MB-231 breast cancer cell line., The overexpression of HIF-1alpha, in serum and especially in pleural effusion, may distinguish malignancy from tuberculosis., siRNA knockdown of HIF-1[alpha] in human microvascular endothelial cells significantly reduced Ang II-induced expression of genes encoding vasoactive molecules., HIF-1alpha is associated with the malignant degree, FIGO stage, histological grade, lymph node metastasis, 5-years survival rate and recurrence rate of gynecological cancer. It may play an important role in clinical treatment and prognostic evaluation, Under hypoxic conditions, HIF-1alpha can facilitate the increased expression of uPA and MMP-7 through the Wnt/beta-catenin pathway, which can promote the invasiveness of gastric cancer cells., The expression of CD146 and HIF1a was positively correlated with EGFR and CD31, respectively in salivary gland adenoid cystic carcinoma., Protein and mRNA levels of PCBP2 were down-regulated under insulin-resistant conditions. Over-expression of PCBP2 inhibits HIF1alpha and STAT3 pathway., These results suggest that HIF1-alpha and AHR integrate immunological, metabolic and environmental signals to regulate the immune response., These findings suggest that at least part of the oncogenic effects of ERbeta2 is mediated by HIF-1alpha and that targeting of this ERbeta2 - HIF-1alpha interaction may be a strategy to treat prostate cancer., microRNA-210 expression was upregulated with an association with HIF-1a overexpression in clinical human catagmatic tissues and was upregulated HIF-1a-dependently in response to hypoxia in osteoblast MG-63 cells, Data suggest that the potential of anti-hypoxia inducible factor 1alpha (HIF-1alpha) targeted therapy is not a candidate for exclusive use in triple negative breast cancer (TNBC), but should be considered in all breast cancers., Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor important for activating innate immune effectors, and the antimicrobial peptide LL-37 (CRAMP in mice) are key determinants of C. albicans colonization resistance., ZEB1 is a direct downstream of HIF-1alpha, suggesting a novel molecular mechanism for HIF-1alpha-inducing epithelial-mesenchymal transition and cancer metastasis., Taken together, these results complement our previous findings and establish bidirectional crosstalk between HIF-1alpha and TAZ that increases their transcriptional activities in hypoxic cells., Data indicate that the reduction of hypoxia-inducible factor-1alpha (HIF-1alpha) expression observed was positively correlated with phospho-mTOR protein reduction., Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha suggesting that Robo4 is positively regulated by HIF-1alpha under normoxic and hypoxic conditions in microvascular endothelial cells in vitro., Data shows that the CpG dinucleotide in HIF-1a hypoxia response element is unmethylated in several embryonic tissue samples, suggesting that transactivation of HIF-1a plays a significant role in HIF-1 mediated hypoxia response during development., Transplantation of HIF-1alpha transfected endothelial progenitor cells attenuates pulmonary arterial hypertension., myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C, results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha, HOTAIR is a direct target of HIF-1a through interaction with putative HREs in the upstream region of HOTAIR in NSCLC cells. Furthermore, HIF-1a knockdown or inhibition could prevent HOTAIR upregulation under hypoxic conditions, Increased ADMA may lead to manifestation of pulmonary hypertension phenotype in human endothelial and smooth muscle cells via the STAT3/HIF-1alpha cascade., Triptolide may suppress HIF1alpha through a cMycdependent mechanism in pancreatic cancer., Results showed that HIF-1alpha overexpression promotes choriocarcinoma cell aggressiveness and metastasis through the regulation of the epithelial to mesenchymal transition through Notch signaling pathway., These findings show that HIF-1-dependent expression and relocalization of HK2 represent a novel mechanism by which Toxoplasma establishes its replicative niche at tissue oxygen tensions., Semi-quantitative real time studies showed decreased HIF-1alpha gene expression on diabetic foot ulcer patients suggesting its possible role on the pathogenesis., Data show that patients with variant alleles (CT+TT) of single nucleotide polymorphisms (SNPs) rs2057482 in hypoxia-inducible factor 1alpha (HIF-1alpha) gene had a significantly lower recurrence risk when compared with patients with the CC genotype., Based on the structure of a well-known HIF1alpha inhibitor., Cancer cells that possess the capacity to normoxically overexpress HIF-1a are particularly sensitive to paclitaxel., The anti-invasive activity of andrographolide in hypoxic rheumatoid arthritis fibroblast-like synoviocytes is largely mediated through inhibition of HIF-1alpha signaling., In this review, we discuss the roles of HIF-1 in both physiological/pathophysiological angiogenesis and potential strategies for clinical therapy., regulation of HIF-1alpha expression in CD4(+) T cells in hypoxia gravely relies on its transcriptional upregulation and subsequent enhanced protein stabilization., Data show that hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) is activated via an proto-oncogene protein Akt/mTOR protein signaling pathway in LCC2 and LCC9 breast cancer cells., HSPA2 expression increased under conditions that stimulated HIF-1alpha activity, whereas inhibition of HIF-1alpha abrogated hypoxia-induced up-regulation of HSPA2 expression, siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not., results suggest that TRPC6 regulates metabolism to affect HIF-1alpha stability and consequent glucose metabolism in human glioma cells under hypoxia, Our findings indicate that miR-199a may attenuate the angiogenic potential of ESCs under hypoxia partly through HIF-1alpha/VEGF-A pathway suppression., Activation of the miR-373-TXNIP-HIF1alpha-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer., the levels of both miR-182 and HIF1alpha were elevated, while the expression PHD2 and FIH1 was downregulated in a mouse model of prostate cancer., Serum HIF-1alpha levels appear to reflect a serious state in patients with acute decompensated heart failure., analysis of the differential dose-dependent effects of simvastatin on HIF-1alpha and BACE in cultured Alzheimer's disease cybrid cells, HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype is triggered by chemotherapy, Data show that both AMPKalpha cleavage and MMP9 expression are required for Toll-like receptor 4 (TLR4)-mediated mTORC1 activation and HIF-1alpha expression., HIF-1alpha as a suppressor of FUT1/2 expression, thereby regulating alpha1,2-fucosylation of cell-surface glycans, HIF-1alpha is upregulated in cell tumor of bone specimens and positively correlated with miR-210 overexpression., The results revealed that DP inhibited the expression of VEGF and HIF-1alpha through the PI3K/Akt/mTOR signaling pathway, confirming that DP may be a potential therapeutic candidate for breast cancer., crystal structures for each of mouse HIF-2alpha-ARNT and HIF-1alpha-ARNT heterodimers in states that include bound small molecules and their hypoxia response element, Taken together, we found that miR-338-3p directly targeted HIF-1alpha, and we provide insight into Nasopharyngeal cancer initiation and progression, possibly representing a novel therapeutic target., Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1., NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha and AP-1-mediated VEGFa expression, Inhibition of HIF-1alpha or miR27a expression decreased MDR1/P-gp., NAT12/NAA30 plays an important role in growth and survival of glioblastoma-initiating cells possibly by regulating hypoxia response (HIF1a), levels of p-MTOR (Ser2448) and the p53 pathway., HIF1A rs11549465 (P582S), rs11549467 (A588T), and rs2057482 (C191T), and WISP1 rs2929970 (A2364G) SNPs were typed in Mexican knee osteoarthritis patients. rs11549465 plays a protective role in the loss of articular cartilage in this population., Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins., Data indicate that both hypoxia inducible factor 1 alpha subunit (HIF-1alpha) and hypoxia-inducible factor 2 alpha (HIF-2alpha) play a role in the metastatic cascade in these two cell lines., High HIF1A expression is associated with Esophageal Squamous Cell Carcinoma., Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1alpha/BNIP3 signaling pathway., melatonin suppresses HIF-1alpha accumulation and VEGF generation via inhibition of melatonin nuclear receptor RZR/RORgamma in SGC-7901 cells under hypoxia., The plasmid p-HIF-1alpha RNAi can effectively and specifically inhibit HIF-1alpha expression, inhibit cell proliferation, and alter the expression of key components in the Wnt/beta-catenin signaling pathway in HCT116 cells., Report NcoA2-regulation of the AhR-ARNT-HIF-1a interaction., Inhibition of HIF-1alpha effectively decreases hypoxia-induced transcription and radiosensitizes hypoxic MG-63 human osteosarcoma cells in vitro., The authors detected that hypoxia induced cell apoptosis via HIF-1alpha/miR-204/BCL-2 in neuronal cells., LPA stimulated interaction of CSN5 with HIF1alpha and MIF. Depletion of CSN5 mitigated the association between HIF1alpha and MIF. We suggest HIF1alpha, MIF, and CSN5 form a ternary complex that is necessary to prevent degradation of HIF1alpha under aerobic conditions, SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-alpha Signaling, High HIF1alpha expression is associated with breast cancer., The results have shown an increased expression of CD31/PECAM1 correlated to HIF-1alpha expression., HIF-1alpha contributes to dendritic cell metabolism and cytokine release in response to Aspergillus fumigatus under normoxic as well as hypoxic conditions., The loss of HIF-1alpha by hypoxic lens epithelial cells decreases the expression of the epithelial to mesenchymal transition marker proteins without sacrificing the levels of the prosurvival protein VEGF., let-7 is a tumor suppressor that negatively regulates RAS, also in Ewing Sarcoma, and HIF-1alpha may contribute to the aggressive metastatic behavior of Ewing Sarcoma, These results suggested that fucosterol executed its protective effects against CoCl2 induced cytotoxicity and inflammation by the inhibition of hypoxia inducible factor through PI3K/Akt pathway., increased nuclear expression indicates unfavorable prognosis in renal cell carcinoma patients [review], HIF-1alpha stabilization under proteasome inhibition is attributed to depletion of the free ubiquitin pool. the state of the ubiquitin pool seems to be a critical factor determining the cellular level of HIF-1alpha., In ARPE-19 cells[Retinal Pigment Epithelium], resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation., Data show that estrogen receptor beta (ERbeta) functions as a repressor of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha)-mediated NF-kappa B (NF-kB) activation., Hypoxia inducible factor-alpha (HIF-alpha) plays a crucial role in coordinating the response to hypoxic conditions., there is a hypoxia response element (HRE) in the nNOS promoter, to which HIF-1alpha may bind. CoCl2 enhanced the HIF-1alpha expression and its binding to this HRE, increasing the transcriptional activity of the nNOS promoter., ASC proliferation was enhanced by hypoxia. HIF-1a activation, FGF-2 production, and the ERK1/2 and Akt pathway were involved in this regulatory mechanism., Auraptene suppresses the progression of renal cell carcinoma cells by inhibiting mitochondrial respiration and directly targeting HIF-1alpha signaling., HIF-1alpha C1772 TT genotype and CC genotype were associated with lung cancer risk, but the T allele was not. Meta-analysis., Data indicate that silencing hypoxia-inducible factor-1alpha (Hif1a ) using siRNAs reduced the expression of miR-19a in moxLDL-stimulated aortic endothelial cells (ECs)., anticancer effect of Evo in human colon cancer may be partly mediated by downregulating HIF-1alpha expression, which is initiated by inactivating PI3K/Akt signaling transduction though decreasing the expression of IGF-1 in colon cancer cells., HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells., Kaiso modulates HIF1A gene expression by binding to the methylated HIF1A promoter in a region proximal to the autoregulatory HIF-1 binding site, primarily during hypoxia., the present study demonstrates a mechanical cascade of BRMS1 suppressing cancer cell invasion through downregulating HIF-1alpha transcript and consequently reducing Snail and TWIST1 expression., HIF-1alpha, stabilized during transplantation, may be able to bind the BKV promoter and enhance BKV replication. Thus, hypoxia should be considered a risk factor for the development of PVAN in kidney transplant recipients., First trimester extravillous cytotrophoblasts in placentas from pregnancy terminations exhibit nuclear localisation of both HIF-1a and HIF-2a., Data show that c-mdm2 proto-ocogene protein (MDM2) expression levels were correlated with hypoxia-inducible factor 1, alpha subunit (HIF1alpha) levels, necrosis and proliferation index in malignant pleural mesothelioma., SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1alpha, The study establishes the importance of inflammation induced HIF-1alpha in integrating two crucial components- the metabolic and immune, through reorganization of cytoskeleton., findings define, for the first time to our knowledge, a direct regulatory pathway between ERalpha and HIF-1alpha, which might modulate hormone response in treatment, HIF-1alpha Pro582Ser single nucleotide polymorphisms may be correlated with type 2 diabetic nephropathy , which needs further exploration, Conditional inactivation of Vegfa, Hif1a, or Epas1 in recruited and resident myeloid cells that accumulated at sites of neovascularization did not significantly reduce choroidal neovascularization or oxygen-induced retinopathy., HIF-1alpha perpetuates the interactions between rheumatoid arthritis synovial fibroblasts and T cells and B cells to induce inflammatory cytokine and autoantibody production, thus exacerbating the severity of rheumatoid arthritis, PLD2 protein itself interacts with HIF-1alpha, prolyl hydroxylase (PHD) and VHL to promote degradation of HIF-1alpha via the proteasomal pathway independent of lipase activity., Interestingly, HIF-1alpha activation markedly suppressed DCA/metformin-induced cell death and recovered the expressions of glycolytic enzymes that were decreased by two drugs., Pretreatment expression of thymidine phosphorylase/HIF-1alpha were found to predict pathologic response and outcomes in clinical stage II/III rectal cancer receiving neoadjuvant chemoradiotherapy., that vascular endothelial cell HIF signaling is necessary for development of hypoxia and pulmonary fibrosis associated pulmonary hypertension, although Hif-1alpha and Hif-2alpha synergize to suppress the development of acute myeloid leukemia, they are not required for leukemic stem cells maintenance., We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a mRNA., Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha-mediated transcription by increasing its protein stability., suggest that tumor and endothelial cell-specific HIF1alpha may have opposing roles in cancer-associated coagulation and thrombosis., Hypoxia inducible factor-1alpha (Hif1alpha), a key mediator of cellular adaptation to hypoxia, is highly expressed and active in three separate mouse models, in hypoxic pancreatic tumors PKM2 interferes both with NF-kappaB/p65 and HIF-1alpha activation that ultimately triggers VEGF-A secretion and subsequent blood vessel formation., The LINK-A lncRNA activates normoxic HIF1alpha signalling in triple-negative breast cancer., Results demonstrate a role for HIF-1alpha methylation in regulating protein stability, thereby modulating biological output including retinal and tumour angiogenesis., High HIF-1alpha expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer., Taken together, our data suggest that constitutive HIF-1alpha protein degradation in hypoxia is absolutely ubiquitination-dependent, and unidentified E3 ligase may exist for this degradation pathway., Therefore, our results support a link between PD and SIRT1/HIF-1alpha signaling, which may serve as a clue for understanding PD., Our results suggest that functional, hypusinated eIF5A is necessary for HIF-1alpha expression during hypoxia and that eIF5A is an attractive target for cancer therapy., Report shows that PIN1 binds to and stabilizes HIF-1alpha, consequently enhancing the angiogenesis., Suggest that the HIF-1alpha-regulated cancer metabolism pathway could be a novel target for overcoming cisplatin resistance in ovarian cancer., Under hypoxic conditions, SIRT2 inhibition increased the ubiquitination of HIF-1alpha in a VHL-dependent manner, leading to the degradation of HIF-1alpha via a proteasomal pathway., Inactivation of HIF-1alpha impairs chemotaxis and cell adhesion to stroma, reduces bone marrow and spleen colonization, regulates cell interaction with tumor microenvironment., High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression., ENO1 was demonstrated to be up-regulated by HIF-1alpha in retinal pigment epithelial cells in response to hypoxia, without influencing VEGF secretion., HIF-dependent regulation of ITGA6 is one mechanism by which sorting for CD49f (+) cells enhances cancer stem cells., High HIF1alpha expression in low glucose condition with improved anaerobic glycolysis seems to be one of the key factors in maintaining the quiescent state of CD34+ stem cells.,
OFFICIAL_GENE_SYMBOL HIF1A,
SP_COMMENT domain:Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID)., function:Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP., induction:Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors, cytokines, and circulatory factors such as PDGF, EGF FGF-2 FGF-2 IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia., online information:Hypoxia inducible factor entry, PTM:In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation. This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol., PTM:In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD1 and EGLN2/PHD2. EGLN3/PHD3 has also been shown to hydroxylate Pro-564. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization., PTM:Requires phosphorylation for DNA-binding., PTM:S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex., PTM:Sumoylated; by SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Desumoylation by SENP1 leads to increased HIF1A stability and transriptional activity., PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains., PTM:Ubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-803., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., similarity:Contains 1 PAC (PAS-associated C-terminal) domain., similarity:Contains 2 PAS (PER-ARNT-SIM) domains., subcellular location:Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia., subunit:Interacts with the HIF1A beta/ARNT subunit; heterodimerization is required for DNA binding. Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with CREBBP and EP300 (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10., tissue specificity:Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.,