Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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hematopoietic cell-specific Lyn substrate 1(HCLS1) hematopoietic cell-specific Lyn substrate 1(HCLS1) Related Genes Homo sapiens
GENERIF_SUMMARY substrate for caspase cleavage during apoptosis, TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells., found in cell types other than hematopoietic cells, HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets, The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization., HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells, HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia., SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs., High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients., a novel role for HS1 and its phosphorylation during neutrophil directed migration., HS1 overexpressed in leukemic as compared to normal B lymphocytes., interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo, Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors., SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.,
SP_COMMENT developmental stage:Expressed in early stage of myeloid and erythroid differentiation., function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression., PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells., similarity:Contains 1 SH3 domain., similarity:Contains 4 cortactin repeats., subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3., tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,