Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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phosphoinositide-3-kinase regulatory subunit 5(PIK3R5) phosphoinositide-3-kinase regulatory subunit 5(PIK3R5) Related Genes Homo sapiens
CYTOBAND 17p13.1,
GENERIF_SUMMARY p101 has a role in membrane recruitment and activation of PI3K gamma, analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma, Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas, Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis., expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways., PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma., data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation.,
OMIM_DISEASE Ataxia-oculomotor apraxia 3,
SP_COMMENT domain:The heterodimerization region allows the binding to the catalytic subunit., enzyme regulation:Greatly activated by G gamma proteins., function:Regulatory subunit of the PI3K gamma complex., subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins., tissue specificity:Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow.,