Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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muscle RAS oncogene homolog(MRAS) muscle RAS oncogene homolog(MRAS) Related Genes Homo sapiens
CYTOBAND 3q22.3,
GENERIF_SUMMARY implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf, These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling., Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43., Both MRAS and SHOC2 play a key role in polarized migration., The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population., The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups.,
SP_COMMENT function:May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway., induction:By interleukin-9, but not by IL-2 or IL-4., similarity:Belongs to the small GTPase superfamily. Ras family., subunit:Interacts with RGL3., tissue specificity:Expression highly restricted to the brain and heart.,