Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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related RAS viral (r-ras) oncogene homolog 2(RRAS2) related RAS viral (r-ras) oncogene homolog 2(RRAS2) Related Genes Homo sapiens
CYTOBAND 11p15.2, 1p32.3,
GENERIF_SUMMARY TGF-beta and TC21 have roles in tumorigenesis, TC21 directly links antigen receptors to PI(3)K-mediated survival pathways., RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 & RasGRF2, but geranylgeranylated TC21 is unresponsive to RasGRF2., Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC., This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors., R-RAS2 is overexpressed in the early stages of malignancy in tumors of the human central nervous system., R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma.,
OMIM_DISEASE Ovarian carcinoma,
SP_COMMENT disease:Defects in RRAS2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome., function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion., PTM:May be post-translationally modified by both palmitoylation and polyisoprenylation., similarity:Belongs to the small GTPase superfamily. Ras family., subcellular location:Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)., tissue specificity:Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.,