Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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fibroblast growth factor 2(FGF2) fibroblast growth factor 2(FGF2) Related Genes Homo sapiens
CHROMOSOME 4,
CYTOBAND 4q26-q27,
ENSEMBL_GENE_ID ENSG00000138685,
GENERIF_SUMMARY Significant association with poor survival by bFGF., Snake venom disintegrin significantly suppresses basic fibroblast growth factor-induced human umbilical vein endothelial cell proliferation, but has little effect on normal growth of the cell., Expression of basic fibroblast growth factor (bFGF) was significantly associated with increased microvessel density in cutaneous melanomas, b-FGF serum levels were significantly higher in patients with chronic myeloproliferative disorders., bFGF up-regulated UPA in both normal and dystrophic myoblasts., Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells, Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway, HTLV-I-transformed T cells, but not HTLV-I-negative CD4(+) T cells, secrete biologically active forms of VEGF and bFGF and induce angiogenesis in vitro., stress-induced release from endothelial cells mediated by integrin alpha v beta 3, plasma basic fibroblast growth factor may have a role in progression of multiple myleoma, level spontaneously secreted by patient CLL B-cells quantified; consistently secreted in all patient samples., REVIEW, FGF2 binds to heparin-derived oligosaccharides and stimulates phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts., Basic fibroblast growth factor may control proteolysis and fibrinolysis in vessel walls by inducing plasminogen activator inhibitor-1 expression in vascular endothelium., possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts, role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction, Biological activity of substrate-bound basic fibroblast growth factor (FGF2), FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway., bFGF and aFGF may suppress endothelial-dependent monocyte recruitment and thus have an anti-inflammatory action during angiogenesis in chronic inflammation but inhibit the immunoinflammatory tumor defense mechanism, Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis., expression associated with poor outcome in non-Hodgkin lymphoma, FGF2 has a role in controlling normal and premature cranial ossification in humans [review], results show that Hensen's node and FGFs induce ectopic expression of cardiac lineage markers, and that FGF and TGFbeta family members can modulate early development of the heart, Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia., FGF-2 is a novel modulator of Lef/Tcf-beta-catenin signaling in endothelial cells, BFGF may sensitively regulate local bone resorption and remodeling through direct and indirect mechanisms that promote angiogenesis and OC recruitment, formation, differentiation, and activated bone pit resorption., This protein has a modulating control of the differentiation of human osteosarcoma cells., Data show that FGF/FGFR signaling stimulates the DNA-binding and transcriptional activities of Runx2 as well as its expression, and these are largely regulated by the PKC pathway., FGF2 and VEGF release by platelets support cell survival and cell growth of vascular endothelium cells in coculture., FGF2 is inhibited by glypican 3 in hepatocellular carcinoma cells, EphA2 does not inhibit endothelial cell survival, migration, sprouting, and corneal angiogenesis induced by this protein., The determination of bFGF will be helpful in estimating the size of infarct lesion at acute stage of cerebral infarction., Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma, bFGF has a stimulating role in lymphangiogenesis, umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass, Fibroblast growth factor-2-induced signaling is mediated through lipid raft-associated fibroblast growth factor receptor substrate 2, IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma., VEGF, but not bFGF, was associated with higher tumor grading of NHL and high-grade transformation of low-grade lymphoma., reduction of neointimal hyperplasia was observed in autologous vein grafts treated by Sendai virus human-fibroblast growth factor 2; these grafts demonstrated significant restoration of endothelium-dependent vasorelaxation, IL-1beta, TNF-alpha, TGF-beta, and bFGF are involved in bone remodeling regulation, acting as local effectors, possibly under the control of PTH., expression system is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint, focal sequences of cell surface heparin/heparan sulphate-like glycosaminoglycans from smooth muscle cells and bovine aortic endothelial cells govern, at least in part, the differential activity of FGF2 on these two cell types, FGF-2, but not VEGF, upregulated the mRNA levels for hTERT and for the hTERT gene transactivation factor Sp1. This restores telomerase activity and maintains the replicative capacity of endothelial cells., FGF-2 was expressed in most human leukemia and lymphoma cell lines tested, but only a small amount was released into the media. It may play a role in apoptosis regulation and pathogenesis., pituitary tumor transforming gene and fibroblast growth factor-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer, TSH stimulates FGFR1 but not FGF-2 expression and PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators so increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis., Alpha-2 macroglobulin and this protein interact at specific binding sites, involving different FGF-2 sequences., pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates, FGF2-stimulated cranial suture closure requires the Erk pathway and activator protein 1, FGF-2-overexpressing melanocytes exhibited marked proliferation, upwards migration, cluster formation and type IV collagen expression within the epidermal compartment, simulating early radial growth phase melanoma, Serum levels of both bFGF and TGF-beta1 were found to be significantly higher in chronic lymphocytic leukemia. Significantly higher in patients with progressive disease., The determination of the FGF-2 5'-ATR RNA secondary structure by enzymatic and chemical probing experiments showed that the FGF-2 IRES contained two stem-loop regions and a G quartet motif that constitute novel structural determinants of IRES function., plasmic degradation of fibrinogen modulates the activity and binding of FGF-2 that involves a site near the carboxyl terminus of the gamma chain, when FGF-2 was incorporated into fibrin, vascular endothelial cell proliferation was increased 6.5 -fold, equal to growth on a fibrin surface with FGF-2 continually present in the medium, role of Egr-1 (early growth response-1)in FGF-2 dependent neovascularization, tumor angiogenesis and tumor growth, FGF-2 clearly enhances cell survival of corneal endothelium after storage at 4 degrees C. Potential future application of FGF-2 as adjuvant to corneal preservation media in order to better maintain endothelial viability during corneal storage., Addition of serum to serum-starved cells rapidly induced intracellular FGF-2 clustering under the plasma membrane and into granules that colocalized with patches of the cell membrane with typical features of shed vesicle membranes., 5 residues (Phe95, Ser100, Asn102, Arg107, and Arg109) from FGF-2 into the corresponding sites in the third cassette of FGF-1 imparted high-affinity binding with dissociation constants (Kd) of 5.3 nM and 8.6 nM, compared to 1.3 nM for wild-type FGF-2., Plasma VEGF and bFGF are elevated in patients with liver cirrhosis depending on age and are predictors of outcome., bFGF adds trabecular bone mass through increasing trabecular number and trabecular connectivity., Data repropose bFGF as a noninvasive diagnostic tool for breast cancer., Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis., increased fibroblast growth factor-2 expression and decreased stromal cell compartment turnover in the diabetic placenta might be a compensatory mechanism in response to the altered physiologic milieu of maternal diabetes on placental function, Recombinant human IGF-2 and IGF-1 synergistically increase the numbers of rat oligodendrocyte progenitor cells recruited into S phase; FGF-2 decreases the levels of cdk inhibitor p27(Kip1) associated with cyclin E-cyclin dependent kinase 2., Fibroblast growth factor (FGF) 2 dramatically enhances the association of FGF receptor (FGFR) 1 with heparin and leads to proposal of a model for the stepwise assembly of a ternary FGF-FGFR-heparan sulfate proteoglycan complex on the plasma membrane., The proangiogenic action of thyroxine is MAPK dependent and mediated by FGF2., Decreased levels of bfgf in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma, lamellipodial protrusion in smooth muscle cells can be regulated by waves of Rac1 activation, corresponding to the sequential presentation of FGF-2 and remodeled collagen., Pulsed electromagnetic field augment angiogenesis primarily by stimulating endothelial transcription and release of FGF-2, inducing paracrine and autocrine changes in the surrounding tissue., Results confirmed basic fibroblast growth factor (bFGF) expression in human adult ovarian cortex, and in the isolated follicles a down-regulation of bFGF mRNA was evident as small follicles develop., upregulation of telomerase activity by FGF-2 plays a functional role in preventing the early onset of senescence, A bipartite nuclear localization signal (NLS) was uncovered near the C-terminus of FGF2. The NLS also contains signals controlling the nucleolar localization of FGF2., These results suggest that bFGF can negatively modulate p38 and positively modulate ERK1/2 to antagonize activin A-mediated growth inhibition and Hb synthesis in K562 cells., This study demonstrates that Chlamydia pneumoniae activates endothelial cells to produce bFGF, a growth factor which is linked to the development of atherosclerotic plaques., fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1., No significantly elevated bFGF levels were found in veins draining tumours compared with arterial samples in a patient population, suggesting that serum bFGF levels might also be derived from other sources besides the tumour, fibroblast growth factor 2 signaling is regulated by IRS-4 and ShcA, Basic fibroblast growth factor has the ability to induce the trans-differentiation into hepatic lineage cells from bone marrow cells., bFGF in plasma and bone marrow stromal cells in idiopathic thrombocytopenic purpura cases are decreased, whereas the production of bFGF remains unchanged., Overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF, two major cytokines in mesangioproliferative nephritis(MN). Caveolin-1 expression vector is potential therapy for MN., HNRNPA1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA, These results provide new evidence for the possible involvement of FGF-2 in the regulation of HA production and its appreciable roles in not only homeostasis but also regeneration of periodontal tissues., chitosan could potentiate FGF-2 activity by protecting it from inactivations by the interaction between FGF-2 and chitosan molecules, The IL-6-mediated bFGF upregulation is through activation of JAK/STAT3 and PI3-Kinase/Akt pathways., The bFGF expression was evaluated in myomas obtained after surgery., bFGF is endogenously positioned to be involved in ongoing neurogenesis in the adult hippocampus., Data show that Npn-1 can potentiate the growth-stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins., opposite effects of Noggin and bFGF for the neural tube development, PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells, A role for FGF2 in cell survival and proliferation of lymphoid and myeloid tumor cells., estrogen-dependent vascular endothelial growth factor (VEGF), especially VEGF165, and basic fibroblast growth factor(bFGF) might work on growth via angiogenesis in the human placenta throughout all trimesters of gestation, Authors show that recombinant human FGF-2 alters osteoblastic expression of bone morphogenetic protein-2 and Msx-2 in vitro to favor cellular differentiation and osteoinduction., essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1., bFGF, but not VEGF, may havea role in systemic hypoxia and anemia in solid tumor patients, analysis of complexes of FGF-2 and regioselectively desulfated heparin in aqueous solutions, Pituitary tumor-transforming gene-1 is up-regulated in human uterine leiomyomas and that the positive feedback loop between PTTG-1 and basic fibroblast growth factor may be pivotal in the growth of leiomyoma cells., Recombinant human FGF-2 signaling enhances the intrinsic osteogenic potential by selectively expanding committed chick embryo osteogenic cell populations as well as inversely regulating bone morphogenetic protein 2 (BMP-2) and noggin gene expression., combination of noggin and basic fibroblast growth factor was sufficient to maintain the prolonged growth of human embryonic stem cells, High expression of Hsulf-1 occurs in the stromal elements as well as in the tumor cells in pancreatic cancer and interferes with heparin-binding growth factor signaling, hrbFGF significantly increased Ki-67-positive cells in colonic epithelium of normal mice and up-regulated gene expression of COX-2, TGF-beta, MUC2, ITF, and VEGF in colon. Rectal administration of bFGF might be treatment for inflammatory bowel disease., finding of FGF2 and EGR1 upregulation in endothelial cell microvascular channels within organising thrombus, Hepatocyte growth factor released FGF-2 in the matrix but did not induce FGF-2 expression in external auditory canal cholesteatoma., FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways, bFGF and GLUT1 play important roles in the carcinogenesis and progression of ovarian epithelial carcinoma., bFGF and vascular endothelial growth factor contribute to a significant proportion of the survival stimulating activity, abnormally sulfated heparan sulfate in Hurler multipotent progenitor cells perturb critical FGF-2-FGFR1-HS interactions, resulting in defective FGF-2-induced proliferation and survival of Hurler multipotent progenitor cells., bFGF was found to bind more strongly to heparin-Sepharose than endostatin, the latter, but not the former, displaced protamine from heparin in solution, which supports the notion that endostatin can compete with bFGF for binding to heparan sulfate, the MAPK and two PLC pathways are required for FGF-2 to stimulate RGC neurite extension in vitro, but the response of axons to FGF-2 applied asymmetrically to the growth cone depended only on the PLC pathways, Expression of b-FGF may be associated with promotion of angiogenesis and a good prognostic factor in squamous cell carcinoma of the esophagus., Results suggest that the release of bFGF following cell death contributes to enhanced chemosensitivity in Non-Small-Cell Lung Carcinoma (NSCLC) cell lines., Not the expression of bFGF in the primary tumour but in its invasion front reflects the aggressiveness of RCC, hereby indicating a different biological potential within both areas., TGF-beta1/bFGF and ET-1 have different roles in graft fibrosis in heart failure patients, bFGF inhibited IR-induced p53 accumulation to some extent in most of these samples and by more than 50% in seven samples from seven patients with chronic lymphocytic leukemia, Significantly higher expression of TGFbeta1 and bFGF, although lower expression of core protein on the concave side, suggesting possible etiological factor or secondary change in development of adolescent idiopathic scoliosis., Using a placental explant model in a fibrin matrix, wtFGF-2 resulted in 2.6-fold more growth over control, and FGF2 binding (to fibrin) mutants increased growth 3.3 -fold. Vessel outgrowth with a nonbinding FGF2 mutant was minimal, comparable to control., The expression of basic fibroblast growth factor (bFGF) and its receptors FGFR-2, FGFR-3, and FGFR-4 in human ovaries suggests that bFGF might have a role in early folliculogenesis., The reciprocal modulating effects of FGF2 and TGFbeta1 on each other's receptors make the GM-490 cell line a new model for investigating the relationship between these growth factors and their receptors in autocrine loops., 18-kDa FGF-2 directly regulates rRNA transcription., Fibroblast growth factor 2 (FGF2) regulates rRNA transcription, in part, by localizing to rRNA genes and directly interacting with the upstream binding factor (UBF), an architectural transcription factor, in the nucleolus., FGF-2 has a role in esophageal cancer recurrence and mortality, existence of an HIF-1alpha-bFGF amplification pathway that mediates survival and sprouting of endothelial cells under hypoxic conditions., excessive release of bFGF from the cartilage matrix during injury, with loading, or in arthritis could contribute to increased proliferation and reduced anabolic activity in articular cartilage, Adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro., MM-LDL and HDL have opposite effects on aortic SMCs, Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane, Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C., These experiments show for the first time that overexpression of basic fibroblast growth factor (bFGF) in developing rodent kidneys can induce the formation of renal cysts in vivo., could play an important role in the pathogenesis of chronic apical periodontitis and periapical cysts, Overexpression of bFGF in skin of patients with systemic sclerosis along with normal serum levels suggests that bFGF probably acts in an autocrine or paracrine manner in fibrogenesis., bFGF expression upregulates CD13 expression in human melanoma cells and results in enhanced invasive capacity and metastatic behaviour of human melanoma cells., A novel mechanotransduction model is proposed in this review that supports a key regulatory role for bFGF in articular cartilage turnover, and highlights its importance as a mechanotransducer., altered HSPGs contribute to enhanced signaling of FGF-2 via FGFR1c in gliomas with glypican-1 playing a significant role in this mitogenic pathway, Study found that a dyad symmetry element (DSE) in the fibroblast growth factor-2 gene promoter exhibited different promoter activities; in HepG2 cells it did, while in U87MG cells it did not, exhibit repressive activity., there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region, analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors, abnormal expression in cartilage of Kashin-Beck disease, VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia, BFGF Is able to increase the migratory activity of Mesenchymal Stem Cells through activation of the Akt/protein kinase B (PKB) pathway., Clearly identify the key function of FGF2 in the maintenance of self-renewal of adipose tissue-derived stem cells., heparanase modifies FGF2 binding, signaling, and angiogenesis in metastatic melanoma cells, Data suggest that the relative concentrations of Anosmin-1 and FGF-2 modulate the migration of oligodendrocyte precursors during development through their interaction with FGFR1., Seminal plasma and PGE(2) can similarly activate FGF2 expression and EP2 receptor signalling in endometrial adenocarcinoma cells., Immunohistochemical expression of bFGF in tumors was confirmed by real-time polymerase chain reaction., Data suggest role for FGFF2 in ductal integrity during mammary carcinogenesis, with loss of expression corresponding to loss of ductal structure., The mRNA levels of BFGF were significantly produced by the megakaryocytes may be associated with the etiology of bone marrow fibrosis in AMM., The serum level of bFGF in patients with exacerbation of chronic cor pulmonale is significantly increased., data show that growth plate perlecan binds to FGF-2 by its heparan sulfate chains but can only deliver FGF-2 to FGF receptors when its chondroitin sulfate chains are removed, The expression of collagen type II and TGF-beta1, bFGF in adolescent idiopathic scoliosis was similar to congenital scoliosis., FGF-2 transgene plays an important role in the establishment of the proper number of dopaminergic neurons and a normal sized substantia nigra during development., The bFGF expression in the endothelial cells of juvenile nasopharyngeal angiofibroma and hemangioma was positive., Intracytoplasmic sperm injection patients with serum progesterone above 0.9 ng/ml have elevated serum concentrations of basic fibroblast growth factor., Real-Time-PCR showed that TGFbeta1 expression is auto-inductive, whereas FGF2 is auto-repressive. The bioavailability of TGFbeta1 regulated by FGF2 may represent part of a negative feedback mechanism controlling stromal growth, differentiation and ECM., Inhibition of BFGF with neutralizing antibodies reduced pro-inflammatory gene expression., role for PGF(2alpha)-FP receptor interaction in modulating FGF2 expression and signaling using an endometrial adenocarcinoma cell line, Data Show bFGF was expressed in regenerative hepatocytes, but not in fibroblasts, suggesting its role in promoting oxidative stress produced by hepatocytes may contribute to the development of fibrous bands in hepatic cirrhosis., Chromatin compaction and cell death by high molecular weight FGF2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria., Overexpression of the 18 kDa basic fibroblast growth factor protein can promote autocrine melanoma cell growth and paracrine-driven angiogenesis., In cartilage, FGF did not significantly affect ROS levels or antioxidant enzyme activity, These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression., study of cellular mechanisms underlying Apert phenotype, by analyzing effects of FGF2 in cultures of Apert periosteal fibroblasts carrying the FGFR2 Pro253Arg mutation, FGF2 has a role in tumor angiogenesis associated with haematological malignancies [review], Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells, Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis., The expression of hTERT, maspin and bFGF correlate to each other, and associate with the malignant degree of glioma., expression not different in endometriosis, The secretion of VEGF and bFGF in myelodysplastic syndrome patients is elevated and the serum levels of VEGF and bFGF are related to the classification and prognosis in MDS., TGF-beta signaling in reactive stroma is angiogenic and tumor promoting and is mediated in part through a TbetaRII/Smad3-dependent upregulation of FGF-2 expression and release., FGF2 may contribute to the synaptic reorganization after noise damage; it may protect and/or aid recovery of synapses after overstimulation., bFGF augments hypoxia induced VEGF release in breast cancer cells mainly through the PI3K pathway and partly depending on HIF-1 activity., FGF-2 release from the lens capsule by matrix metallopeptidase 2 is essential to lens epithelial cell viability and survival, Provide useful information for understanding mechanisms of angiogenesis induced by bFGF and important data for validating a mathematical model of angiogenesis., BFGF activates the MAPK and NFkappaB pathways that converge on ELK1 to control production of MMP13 by articular chondrocytes., bFGF may promote obviously the healing of orbital implant exposure, particularly it can be the first choice for the treatment of mild degree exposure., Fibrin gel-immobiized VEGFA and BFGF efficiently stimulate angiogenesis in the AV loop model., alpha-Tocopheryl succinate disrupts angiogenesis mediated by malignant mesothelioma cells by inhibiting FGF2 paracrine signalling, bFGF does not directly act on p38 nor on the mRNA expression levels of activin receptors but inhibit activin A activation of p38 upstream of p38 in K562 cells., Exogenous human FGF-2 increased endogenous FGF-2 promoter activity and protein levels in ovine pulmonary arterial smooth muscle cells., endogenously synthesized fibrinogen promotes the growth of lung and prostate cancer cells through interaction with FGF-2., Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor (FGF-2), activen A expression is induced by wounding in an FGF-2- and NF-kappaB-dependent manner, Study demonstrates that the fibroblast growth factor-2 binding site of thrombospondin-1 is located in the type III repeats., Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of proliferative diabetic retinopathy., IGF-1 and EGF down-regulation and FGF2 up-regulation seem to comprise the main features of endometrial carcinogenesis., We propose FGF-2 negative feedback as potentially important in microvascular remodelling. This is consistent with the absence of a secretory signal sequence in FGF-2, as well as canalicular fragmentation, which is unique to endothelial apoptosis., Developed a mathematical model to numerically simulate angiogenesis induced by basic fibroblast growth factor (bFGF) in the corneal pocket assay., Basic fibroblast growth factor regulates expression of heparan sulfate in human periodontal ligament ce, the involvement of FGFR-1 through FGF2 in eliciting PGE(2) angiogenic responses, The expression levels of endostatin, VEGF and FGF-2 in laryngeal squamous cell carcinoma are obviously higher than those in para-carcinoma and normal laryngeal tissues., Local controlled release of bFGF from the stent-graft significantly accelerated the proliferation of new intimal tissue between the aorta and the stent-graft and within the graft materials., REVIEW, bFGF is a mitogen for the rapidly dividing cells (olfactory neuronal precursors and olfactory ensheathing cells), and also a survival factor for both slowly and rapidly dividing cells of the olfactory mucosa., FGF2 was among the genes differentially expressed in an in vivo-in vivo comparison between unfused and prematurely fused calvarial tissue., In vitro, primary effusion lymphoma -induced angiogenesis is dependent on VEGF and VEGF receptors. However, although PEL cells produce VEGF and bFGF transcripts, they only secrete VEGF in vitro, Support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability., Our data first suggest that JNK participates in bFGF-mediated surface cadherin downregulation. Loss of surface cadherins may affect the cell-cell interaction between endothelial cells and facilitate angiogenesis., Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1, FGF-2 expression in malformations of cortical development reflects incomplete differentiation and maturation of dysplastic cells, Sox2-expressing MSCs showed consistent proliferation and osteogenic capability in culture media containing bFGF, bFGF differently changes intracellular signals in ECs depending whether it is applied under microgravity or normal gravity conditions, in angiogenesis,FGF-2(fibroblast growth factor 2)-mediated enhancement of Placental growth factor (PGF) expression was dependent on Vascular endothelial growth factor function, AT genotype of the 553 T/A polymorphism was associated with PDR in Caucasians with type 2 diabetes., potent mitogenic signaling results from heparin-mediated trans-dimerization of FGF2, consistent with the asymmetric model of ternary complex formation, bFGF immunoreactivity was found to be increased in fibroblasts and in endothelial cells in early oral submucous fibrosis cases, while the expression of bFGF in stroma increased notably in advanced fibrosis., identified activin-mediated transforming growth factor (TGF)-beta signaling, platelet-derived growth factor (PDGF) signaling and fibroblast growth factor (FGF) signaling as the key pathways involved in MSC differentiation, vascular endothelial growth factor A and fibroblast growth factor 2 have effects on chemotaxis and chemokinesis, VEGF-A and FGF-2 mRNA levels were higher in the outer definitive zone of fetal adrenal gland than in the fetal zone., a transient interaction with PI(4,5)P(2) associated with the inner leaflet of plasma membranes represents the initial step of the unconventional secretory pathway of FGF-2, Document a role for FGF-2 and PDGF-BB in the temporal regulation of coronary artery stem formation and growth of the coronary arterial tree., The findings suggest interactive and sequential roles for FGF2 and NT3 on cochlear ganglion development, beta(2)GPI inhibits VEGF and bFGF-induced proliferation, migration and papillary-like tubule formation of HUVECs, The expression of Livin was positively correlated with the expression of bFGF in laryngeal squamous cell carcinoma., bFGF has an effect on the proliferation of human adenoid cystic carcinoma ACC-2 cells, ATP-binding on fibroblast growth factor 2 partially overlaps with the heparin-binding domain, Nucleostemin expression in cardiomyocytes is induced by fibroblast growth factor-2 and accumulates in response to Pim-1 kinase activity., A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer., Results reveal that platelet-derived growth factor-B-activated fibroblasts play a key role in the recruitment/migration and differentiation of mesenchymal stem cells and implicate a bFGF- and CXCL5-dependent mechanism in mediating these effects., Measuring PDGFA, bFGF, and HIF1a expression may contribute to a better understanding of the prognosis of patients with pancreatic cancer., bFGF-eluting stents are effective for accelerating organization of the thoracic aneurysm cavity and developing neointima., The delivery of bFGF was employed to stimulate proliferation and survival of primary intestinal smooth muscle cells., FGF-2 delivery from self-assembling nanofibers facilitated islet transplantation in diabetic mice., mitogenic properties of FGF-2 were maintained when SOX9 was co-overexpressed and concomitant with an increase in the production of proteoglycans and type-II collagen, subconfluent pulmonary artery smooth muscle cells express predominantly S1P2 and S1P3 receptors; S1P1 receptor mRNA levels are significantly up-regulated following bFGF treatment, Report inhibitory effects of biodegradable gelatin hydrogel sponge impregnated with bFGF on the progression of experimental abdominal aortic aneurysms., Secreted proteoglycans directly mediate human embryonic stem cell-basic fibroblast growth factor 2 interactions critical for proliferation, bFGF can play an important role in modulating plasticity and neuronal fate of human neural stem cells, Myometrium conversion into leiomyoma and an increase in its mass is accompanied by a significant increase in aFGF gene expression., bFGF, FGFR1, and FGFR2 are frequently overexpressed in squamous cell carcinoma and adenocarcinoma of the lung and may have a role in neoplasm pathogenesis, HMW FGF-2 inhibits tumor growth in glioma cells by acting on cell-cycle progression and protein translation., TGF-beta(transforming growth factor beta1), PDGF-AB (platelet derived growth factor AB) and bFGF (basic TGF-beta, PDGF-AB and bFGF) concentrations in subacromial space were higher than in the serum, FGF-b immunoreactivity in cytotrophoblasts and capillary endothelium of chorionic villi of preeclamptic subjects increased., Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice., Differences in potency or other unknown factors contribute to whether subsets of FGF-like autoantibodies from breast cancer sera exhibit long-lasting neurotrophic and neuroprotective effects or an early neurotrophic effect followed by late neuron death., E22Q and WT peptides suppressed FGF-2 expression while E22G had barely any effect. Phosphorylation of the FGF-2 receptor, FGFR-1, and the survival signal Akt were abolished by E22Q and WT peptides, but not by E22G, FGF-2 is a new substrate of PRMT5., At the early stage of tumor growth bFGF expression play important roles in the regulation of angiogenesis, tumorigenicity and subsequent metastases of human bladder cancer., FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS., These data further suggest an integral role for visfatin-FGF-2 signaling axis in modulating endothelial angiogenesis., These findings showed that HDAC inhibition antagonized FGF2 and IL-1beta induced MMP expression in articular chondrocytes., In this review, while other cell types express basal levels of plasma cell membrane glycoprotein PC-1, FGF2 only induces PC-1 expression in osteoblast related cells., Construction and characterization of a novel superantigen fusion protein, These data suggest that APO can enhance the biosynthesis and release of FGF-2 through the activation of the MZF-1 transcription factor in striatal astrocytes., Endothelial FGF2 is overproduced in pulmonary hypertension[PH] and contributes to pulmonary hyperplasia, identifying FGF2 as a potential agents against PH. potential new treatment against, Low plasma bFGF may be a marker for the presence of anti-endothelial cell autoantibodies that may contribute to the need for laser photocoagulation treatment in adult men with advanced type 2 diabetes mellitus., a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas, NMR results identified the amino-acid residues involved in the direct interaction of CXCL4 (47-70) with FGF-2., The role of FGF2 in high glucose-altered molecular signaling in pathogenesis of diabetic renal disease was studied in renal biopsy samples and cultured fibroblasts., endogenous bFGF affects the expression of angiogenin in HeLa cells., FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells., overexpression mediated by the recombinant plasmid accelerated periodontal regeneration, High tumor cell FGF2 expression is associated with non-small cell lung cancer., knockdown of RGS14 inhibited both nerve growth factor- and basic fibrobast growth factor-mediated neuronal differentiation of PC12 cells, HDAC5 represses angiogenic genes, such as FGF2 and Slit2, which causally contribute to capillary-like sprouting of endothelial cells., High glucose concentration in cell culture medium does not acutely affect human mesenchymal stem cell FGF2 production or proliferation., Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer., that FGF-2 induces differentiation of neuroblastoma cells via activation of a complex gene expression program enabling modulation of cell cycle, transcription factors, and suppression of the cancer phenotype., Stimulation of VEGF protein secretion by bFGF overexpression in human melanoma cells is regulated by activation of PI-3K and p38 MAPK., engineering neural progenitors to overexpress FGF-2 may be a suitable strategy to improve the integration of grafted neural progenitor cells with the host vasculature thereby generating neurovascular clusters with a neurogenic potential for brain repair., Data suggest the feasibility of modifying BMSC with nonviral delivery systems for bFGF expression., HGF and bFGF mRNA expression can be used as useful parameters to evaluate the prognosis of gastric cancer., FGF2 induces expression of a wide repertoire of inflammation-related genes in endothelial cells, e.g. pro-inflammatory cytokines/chemokines & their receptors, endothelial cell adhesion molecules, & prostaglandin pathway components. Review., analysis of FGF-2 stimulation of RANK ligand expression in Paget's disease of bone, this is the first study investigating the association of antidepressant response and intolerance with FGF2 variants., the novel TIMP-free MMP-9/FGF-2/FGFR-2 pathway in proMMP-9-induced angiogenesis in a mammalian setting., hypoxia induces up-regulation of VEGF (vascular endothelial growth factor) and bFGF(basic fibroblast growth factor) in Adipose-derived stem cells and enhances wound healing, Fibroblast growth factor-2 regulates the stability of nuclear bodies., NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway., endogenous bFGF may not only negatively regulate the angiogenin expression but also contribute to the overall cell proliferation in H7402 human hepatoma cells, Repeated low-dose drug administration (metronomic therapy) of ibandronate has certain anti-angiogenic properties by inhibiting the stimulatory effects of bFGF., bFGF and EGF have a role in optimizing the proliferative capacity of cryopreserved human adipose-derived stromal/stem cells, binding of anosmin-1 to FGFR1 and heparin can play a dual role in assembly and activity of the ternary FGFR1.FGF2.heparin complex., Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathway., DNA dependent protein kinase suppression with the compound NU7026 or with siRNA induced basal endothelial cell proliferation as well as enhanced FGF-2 dependent proliferation., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., caspase-mediated anoikis inhibition is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells, FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells, Suggest a broader gut endodermal patterning activity of FGF2 in embryonic stem cells that corresponds to what has previously been advocated for FGF4, implying a functional switch from FGF4 to FGF2 during evolution., Hypoxia promotes FGF2- and VEGF-stimulated cell proliferation without further activation of the PI3K/AKT1 and MEK1/2/ERK1/2 pathways, respectively., These results suggest that positive feedback regulation of bFGF and IGFs leads to proliferation of hUCB-MSCs., Polymorphisms in the promoter region of the basic fibroblast growth factor is not associated with myocardial infarction in a Slovene population with type 2 diabetes., overexpression of HMW FGF2 increases FGF23/FGFR/KLOTHO signaling to down-regulate NPT2a, causing P(i) wasting, osteomalacia, and decreased bone mineral density, The positive rate of bFGF and TGF-beta1 in normal salivary glands were apparently lower than those in malignant mucoepidermoid carcinomas., The expression of OPN protein and mRNA was up-regulated by FGF-2 in A549 cells., VEGF and/or bFGF (10 ng/mL) application influenced the accumulation of proteins in supernatants more profoundly under 1 gravity than under simulated microgravity., bFGF regulates ERK oscillations in premalignant but not malignant JB6 cells, 15(S)-HETE-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2., thrombospondin-1 mimics are fibroblast growth factor-2 inhibitors, FGF2 high molecular weight (HMW) isoforms have a role in the development of cardiac ischemia-reperfusion injury, Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells, high expression of VEGF and bFGF indicate that both contribute in the angiogenesis of endometrial cancer., The increased gene expressions of bFGF, alpha-SMA and PCNA in atrium during atrial fibrillation may contribute to atrial fibrosis by promoting fibroblast proliferation., TRAIL induction involves FGF-2, Sp1-phosphorylation and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury., Data show that fibroblast growth factor-2 is regulated by an endogenous antisense RNA and by argonaute-2., Three of four angiogenic factors, VEGF, b-FGF and IGF-I, are higher concentration in human milk which collected from preterm mothers than those of terms., Increased plasma basic fibroblast growth factor immunoreactivity may be a novel risk marker for coronary heart disease occurrence in adult men with advanced type 2 diabetes mellitus., adipose tissue-derived stem cells have the capacity to differentiate into capillary structures and bFGF plays a critical role in this process., Tec kinase has a crucial role in regulating FGF2 secretion under various physiological conditions, SOCS-3 is a novel modulator of FGF-2-regulated cellular events in prostate cancer., stimulates bone sialoprotein transcription in MCF7 human breast cancer cells by targeting the AP1 and CRE2 elements in the human bone sialoprotein gene promoter, peripheral and local serum levels of bFGF in patients with hemangiomas and vascular malformations, long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2, FGF2 induction of NOS3 expression is mainly mediated by AP-1-dependent transcription involving JunB and Fra1 up-regulation via sustained ERK2/1 activation in endothelial cells, A novel NF-kappaB-mediated pathway linking bFGF with iNOS and MMP-9 expression is associated with carotid plaque vulnerability., Elevated levels of VEGF and bFGF may activate the process of neoangiogenesis, which may lead to increased perfusion and an improvement in tissue oxygenation in COPD patients, The FGF2 754C/G polymorphism is associated with a risk of developing endometriosis and adenomyosis in north Chinese women., Specific FGF-2 receptors were found in the malignant epithelial but not in the benign myo-epithelial cells of salivary gland carcinoma ex-pleomorphic adenoma, indicating a paracrine role for benign myoepithelial cell-derived FGF-2., bFGF has a role in growth of human primary prostatic stromal cells, A novel TERT-bFGF axis accelerates the inactivation of p53 and consequent increase of resistance to DNA-damage response., investigation of role of bFGF in invasiveness of ovarian cancer, Decreased expression of VEGF and bFGF can inhibit the invasion and proliferation of pancreatic cancer cells., FGF2 helps to maintain genomic integrity in stem cells by activating stress-induced DNA repair., demonstrate here that galectin-3 is a mediator of vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-mediated angiogenic response., Provide evidence of Notch1-dependent endothelial FGF-2 induction by visfatin and of Notch1 activation in visfatin-stimulated endothelial angiogenesis., There were a positive correlation between the proliferation and aggressiveness of B-cell non-Hodgkin's lymphoma as measured with Ki67 and both VEGF and b-FGF., FGF-2 activated the migration of MPDL22 cells and phosphorylation of phosphatidylinositol 3-kinase (PI3K) and akt., BFGF activates MEK/ERK cell signaling pathway and stimulates the proliferation of primordial germ cells., Authors found a linear relationship between the expression of FGF2 and the level of HMGA2 overexpression as well as the tumor size, and that stimulation of myometrial tissue by a strong inducer of HMGA2, leads to an increase of FGF2 expression., Cell-cycle analysis following siRNA-mediated knockdown of NUDT6 or FGF2 indicate that both factors are involved in control of transition through the G and G boundaries, affecting cell-cycle progression, proliferation, and apoptosis., The overexpression of bFGF and underexpression of PTEN are closely related to the invasion and growth of cervical carcinoma., FGF2 overproduction contributes in an autocrine manner to the altered endothelial phenotype characteristic of idiopathic pulmonary arterial hypertension., investigation of role of FGF2 secretion by vascular endothelial cells during trophoblast invasion under cell hypoxia as a model of placentation under physiological stress (a model for role of FGF2 in cellular events leading to preeclampsia), There were no significant changes in bFGF in response to high intensity exercise or high-volume training., bFGF has a role in growth and maintenance of human embryonic stem cells, Fibroblast growth factor-2 promotes mitral valve interstitial cell wound repair, at least in part, through the TGF-beta/Smad2/3 signaling pathway., Data show that HSulf-1 depletion in breast cancer cells resulted in an increased and sustained bFGF2 (basic fibroblast growth factor) signaling and promoted cell migration and invasion under hypoxic conditions., recombinant human bFGF protein induced matrix metalloproteinase-1 , plasminogen activator inhibitor-1, and cathepsin L expression in skeletal muscle cells, basic fibroblast growth factor may be involved in the mechanisms controlling dental pulp stem cell fate decisions, FGF-2 upregulation in neurons and balloon cells is an important feature common to tuberous sclerosis and focal cortical dysplasia (FCD) with balloon cells, Transmyocardial revascularization with a bFGF-incorporated degradable stent improved global left ventricular function and attenuated left ventricular remodeling., role of the NRE of HS in FGF2 signaling and favor the formation of the symmetrical architecture on short NS domains., Examines the potential of recombinant cytokines, particularly basic fibroblast growth factor (bFGF, FGF-2) to promote periodontal tissue regeneration, and discusses the present and future outlook of FGF-2 therapy in periodontal treatment [review], Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death., Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells., amitriptyline-induced FGFR activation might occur by the MMP-dependent shedding of FGFR ligands, such as FGF-2, thus resulting in GDNF production, Findings suggest that there is a cooperation mechanism between basic fibroblast growth factor and angiogenin in A375 cells, and the cooperation mechanism affects the progress of tumor cell proliferation and angiogenesis., changes in endogenous FGF-2 levels contribute to FGF-1's early adipogenic effects and highlight the complexity of the paracrine interplay between FGFs within human adipose tissue, JNK/SAPK signal pathway plays an important role in regulating bFGF-mediated angiogenesis in HUVECs, FGF signaling coordinately regulates mineralization-related genes in the osteoblast lineage and that ERK signaling is essential for Dmp1 expression and osteocyte differentiation., report demonstrates that engineered porous coral constructs using bFGF gene-transfected human BMSCs may be a feasible option for surgical transplantation in TMJ repair, The effects of the small molecular inhibitors of VEGF receptor 2 and other tyrosine kinases on pro-angiogenic responses through VEGF-A and basic fibroblast growth factor are reported., ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway., This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from Non-gastrointestinal stromal tumor soft-tissue sarcomas patients., survivin, through upregulation of VEGF and bFGF, plays an essential role during glioma angiogenesis, High BFGF is associated with colorectal cancer., The mRNA expression of VEGF and bFGF, the protein expression of VEGF, bFGF, and ES and microvessel density (MVD) are increased both in the uraemic predialysis and peritoneal dialysis patients., Endothelial caveolin-1 functions as a platform for regulating FGF2-induced angiogenesis through spatiotemporally compartmentalizing FGFR1 and the AKT1 and ERK1/2 signaling modules., Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling., FGFR1 is the major mediator with the degenerative potential in the presence of FGF-2 in human adult articular chondrocytes, Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells., FGFR3c, critical for bone development, elicit a similar response to Fgf1 and Fgf2 at low, but not at high, concentrations; results demonstrate the versatility of FGFR3c response to fgf1 and fgf2 and highlight the complexity in fgf signaling., Mean serum values of b-FGF were significantly higher in multiple myeloma compared with controls & with increasing disease stage. A complex network of cytokines induces bone marrow neovascularization in MM., The expressions of VEGF, bFGF, and BMP-2 mRNAs decline in traumatic and nontraumatic avascular necrosis of femoral head., Levels of FGF2 and FGFR1 in saliva and serum from patients with salivary gland tumors were significantly higher than those from healthy control subjects suggesting their potential use as cancer biomarkers., The extracellular matrix of benign myoepithelial cells induces the increase in fibroblast growth factor 2 expression., a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription., Chlamydia trachomatis elementary bodies bind to FGF2, which facilitates bacterial binding. FGF2 promotes internalization of EBs via FGFR. C. trachomatis stimulates FGF2 transcription, production, and release to facilitate additional rounds of infection., Rates of expression of b-FGF in osteosarcoma and osteochondroma were 76.7% and 43.3% respectively. There was no correlation between b-FGF and endostatin expression in the osteosarcoma group., The results of this study proposed that FGF-2 and Anosmin-1 are markers for the histopathological type and the level of inflammation of multiple sclerosis lesions, Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells., the serum VEGF and bFGF level can be used as indicators of AL efficacy, and are correlation with the prognosis of children with AL., polySia-NCAM might be involved in the regulation of FGF2-FGF receptor signaling through the direct binding of FGF2 in a manner distinct from heparan sulfate., Report increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma., Report bFGF nasal spray improves rat memory impairments induced by co-injection of beta-amyloid and ibotenic acid into the bilateral hippocampus., The combined blockade of the signaling pathways of several growth factors, including Fgf2, might be useful in controlling the aggressiveness of osteosarcoma., The results provide evidence for gene interactions among BDNF, FGF2, and VEGFA in stroke outcome, In vivo stimulation of BT-474 cell growth by progesterone is associated with down-regulation of FGF-2., Heparanase can induce angiogenesis to promote tumor growth by releasing bFGF and VEGF in nasopharyngeal angiofibroma., TSG-6 reverts the inhibitory effects exerted by PTX3 on FGF2-mediated angiogenesis through competition of FGF2/PTX3 interaction., The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased., FGF2 genetic variants are unlikely to influence susceptibility to myopia., found that increased Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin protein, the delivery to the injury region of the therapeutic genes vegf and fgf2 reduced cavitation, restrained the processes of secondary degeneration and supported the number of myelinated fibers in the injured spinal cord., Tested feasibility of using bioprinting for cartilage engineering. Bioprinted samples treated with FGF-2/TGF-beta1 had the best chondrogenic properties among all groups., FGF-2-deficient mutant superoxide dismutase (SOD)1 mice show a significant delay in disease onset and less impaired motor performance in comparison to mutant SOD1 mice with normal FGF-2 levels., FGF2 delivery to human adipose-derived stem cells transplantation sites enhances their long-term angiogenic efficacy transplanted into ischemic tissues., VEGF and bFGF may participate in the pathogenesis of inflammatory pericardial disease, Transduction with FGF-2 encoding lentiviral vectors resulted in overexpression of the respective isoform in all tested cell populations., Mucosal TNF-alpha is overexpressed only in symptomatic diverticular disease, while SD1 and bFGF are already overexpressed in asymptomatic diverticulosis., Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion., FGF2 was found to mediate DNA repair in epidermoid carcinoma cells, The extracellular signals of NGF and bFGF induced neuron differentiation of human endometrial stem cells., Phosphate-independent effects of high-molecular weight (HMW) isoforms in vitro may be directly mediated in part via FGF23 and HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro., FGF2 was significantly higher in the metastatic vs. the non-metastatic urothelial cell carcinoma of the urinary bladder., Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor., Data suggest that FGF2 is involved in regulation of Sertoli cell function; CREB (cAMP responsive element binding protein) phosphorylation in cultured rat Sertoli cells appears to be up-regulated by human FGF2 or interleukin-1beta., An inhibition study of bFGF receptor demonstrated that the improvement of cell proliferation resulted from the role of bFGF released from the CPCs., In the tumor microenvironment, the reciprocal interplay between FGF-2 and VEGF-C collaboratively stimulated tumor growth, angiogenesis, intratumoral lymphangiogenesis, and metastasis., BFGF is upregulated in POEMS syndrome. It could not be ruled out that this increase was due to feedback of elevated VEGF levels., Fibroblast growth factor 2 stimulates FGFR-2 expression, resulting in decreased TWIST1 expression and increased Runx2, alkaline phosphastase and osteopontin expression., This work reveals an anti-angiogenic role of STAT1 activation that acts in Tie2-R849W-expressing endothelial cells to impair VEGF-A-mediated STAT3 signaling, bFGF production, and smooth muscle cell recruitment., These findings suggest human serum, FGF-2 and TGF-beta3 as possible candidates to support biological treatment strategies of AF defects., High basic fibroblast growth factor is associated with renal cell carcinoma progression., Delivery of the therapeutic genes VEGF and FGF2 to the damaged region and their expression in cell carriers stimulates vascularization and post-traumatic spinal cord regeneration., The ASM cell differentiation promoted by TGF-beta is antagonized by FGF-2., Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer., FGF2 binds to LYVE-1 with a higher affinity than any other known LYVE-1-binding molecules, such as hyaluronan or PDGF-BB. Glycosylation of LYVE-1 is important for FGF2 binding., Correlative Hsp47 expression in fibroblasts with bFGF in inflammatory cells may contribute to stromal fibrosis and obstruction in colorectal carcinoma, Expression levels of VEGF and bFGF are significantly decreased in pressure ulcer wounds at stage III-IV., FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression., Il-1beta enhances cell migration through AP-1 and NF-kappaB pathway-dependent FGF2 expression in human corneal endothelial cells., No significant relationships were observed for bFGF polymorphism and susceptibility to B cell chronic lymphocytic leukemia, a novel mechanism for hypoxia-induced FGF2 and VEGFA through HIF1alpha-mediated inhibition of miR-503, Fibroblast growth factor 2 (FGF-2) strengthens the endothelial cell blood-brain barrier function by increased occludin and ZO-1 expression., FGFR2 rs1219648 variant is more strongly associated with breast cancer risk in estrogen-only hormone users, Nck plays a pivotal role in integrating FGF-2 and endoplasmic reticulum (ER) stress signals to counteract the ER stress deleterious effect on cancer cell survival., studied the functional consequences of HSulf-2 activity on fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities, high expression in uterine leiomyoma, correlated with T-cadherin, results indicate that FGF2 increases BSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human BSP gene., FGF2 -FGFR1 activation through an autocrine loop is a novel mechanism of acquired resistance to EGFR-tyrosine kinase inhibitors., The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients., Up-regulated cten modulates cell migration induced by FGF2., A novel role for FGF2 in regulating PDGFRA expression in a subset of gliomas with younger age at disease onset and longer patient survival regardless of the morphological diagnosis., These findings indicate that bFGF could rapidly activate the protein kinase B activities, enhance the expression of survivin and the proliferation of hepatocellular carcinoma cells via the PI3K pathway., All stem cell lines were expanded with fibroblast growth factor-2., Tumor cell expression of FGF-2 proved to be an independent prognostic factor for LRC and OS. This factor can help personalize treatment and stratify patients in future trials., Cell population growth indices were higher for those in FGF-2 supplemented media., The biomarker profile comprised of NGAL, FGF-2, and EGF increased the specificity to detect acute kidney injury in critically ill children, Defective placental maturation is associated with an imbalance of expression of bFGF and prokineticin (PK) receptor 2., Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF., EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1., These data suggest that the upregulation of either IL-8 or bFGF is closely related to the transition from liver cirrhosis into HCC., Results suggest that small subsets of circulating CD30+/CD15+ cells expressing FGF2 and SDC1 represent biomarkers that identify NS-cHL patients who will experience a poor outcome., Data suggest that the enhanced cell growth was likely due to the electrical stimulation up-regulated secretion of FGF-1 and FGF-2., show that these classical mitogenic pathways do not mediate the cytostatic activity of FGF2, P = 0.095) and healthy individuals (0.37 versus 0.19, OR = 2.51, P = 0.038). These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL., Fibrosis and subsequent cytopenias are associated with basic fibroblast growth factor-deficient pluripotent mesenchymal stromal cells in large granular lymphocyte leukemia., Intrapleural administration of sustained-release basic fibroblast growth factor induced lung regeneration in rats with elastase-induced pulmonary emphysema., Mechanistic insights into the S100B-FGF2 complex interface and cell-based assay studies involving mutants led us to conclude the novel role of S100B in FGF2 mediated FGFR1 receptor inactivation., Transcriptome analysis comparing control adult human fibroblasts with FGF2-treated fibroblasts identified functional groups of genes that reflect transcriptional changes potentially contributing to their regeneration competence., expression of Mll-Ell in myeloid progenitor cells resulted in autocrine production of Fgf2 and Fgf2-dependent cytokine hypersensitivity., study has identified an upregulation of a proangiogenic signature in bevacizumab-refractory Head and Neck Squamous Cell Carcinoma tumors that converges on ERK signaling to upregulate FGF2, which then mediates evasion of anti-VEGF therapy., Metastatic melanoma patients who achieve FGF-2 suppression are more likely than those who do not to have a response or stable disease., FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels., Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma., TbetaRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TbetaRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK., bFGF mRNA is significantly overexpressed in acute colonic diverticulitis compared to ileocolonic Crohn's disease., In mesenchymal stem cells from aplastic anemia patients, FGF2 gene expression was downregulated. Within the patients' bone marrow, low FGF2 expression was validated both in mononuclear cells and in the extracellular fluid., APE1-small interfering RNA significantly inhibited tumor angiogenesis by downregulating in vitro expression of FGF2 and FGFR3., High serum FGF2 levels are associated with gastric and gastroesophageal junction cancers., FGF2 overexpression is associated with triple-negative breast cancer., elevated extracellular concentration of ONOO- produces an upregulation of the angiogenic factors VEGF, hypoxic-inducible factor-alpha (HIF-1alpha), and BFGF in a human corneal limbal epithelial (HCLE) cell line., Identification of critical factors needed for reprogramming may allow for nonviral, chemically defined derivation of human-induced multipotent cells that can be maintained by exogenous FGF2., FGF2 transcriptionally stimulated the expression of miR-149 independently of its host gene, We found that transforming growth factor-beta, in contrast to fibroblast growth factor-2 and interleukin-6, promotes human pulmonary pericyte differentiation into contractile smooth muscle-like cells., The results of bisulfite genomic DNA sequencing showed that in HCAECs treated with oxLDL, the GC-rich promoter of FGF2 was heavily methylated at cytosine residues, whereas cotreatment with anti-MDA markedly reduced oxLDL-induced FGF2 promoter methylation, Nuclear targeting of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion., The results presented here indicate that histone acetylation and additional chromatin modifiers are important in determining the relative levels of FGF2 and NUDT6., interplay between hCG and bFGF occurred by activation of the p44/42 MAPK signaling pathway, osteogenic induction by the sequential delivery of BMP-2 followed by FGF-2 from core-shell microspheres was even worse than that from microspheres loaded with BMP-2 in both core and shell, although comparable to the cases of parallel delivery of dual GFs, suggest that FGF2 inhibits osteoblast mineralization by limiting the capacity of matrix vesicles., The paracrine effect of USCs or USCs-FGF2 induced improvement of erectile function in type 2 diabetic rats by recruiting resident cells and increasing the endothelial expression and contents of smooth muscle., FGF2 enhances formation of HIF-1 nuclear complexes via ERK pathway., These data suggested that Epac1 in melanoma cells regulates melanoma progression via the HS-FGF2-mediated cell-cell communication., Overexpression of FGF-2 and SMA is associated with local recurrence and reduced recurrence-free survival after definitive CRT for esophageal squamous cell carcinoma, Serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder were significantly higher than those in healthy controls, Hi-FGF-2 represents a substantial fraction of FGF-2 in human cardiac (atrial) tissue., bFGF mRNA expression did not vary between chronic diverticulitis and Crohn's disease., MT1-MMP controls FGF-2 signaling by a proteolytic mechanism that decreases the cell's biological response to FGF-2, FGF2 acts as a protective growth factor after lung epithelial injury, and call into question the role of FGF2 as a profibrotic growth factor in vivo., ower serum FGF-2 levels contribute to the pathophysiology of major depressive disorder and that FGF-2 may be used as a peripheral biological marker, this is the first study to demonstrate that bFGF can induce EMT via AKT/GSK-3beta/Snail signaling pathway in prostate cancer cells., FGF-2 facilitated the collagen-producing potency of hBMSCs both in vitro and in vivo, rendering them more suitable for use in collagen regeneration in the clinical field., These studies demonstrate a feedback loop between Klotho depletion and FGF2 activation in renal fibrosis., miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2., High bFGF levels are associated with gynecologic cancer., hBM MSC can be coaxed to differentiate efficiently into dopaminergic neurons in the presence of a very simple media cocktail containing only one main inducer like FGF2, TSP-1 cooperates with FGF-2 and VEGF/VEGFR-1 in determining melanoma invasion and metastasis, as part of a Slug-independent motility program., we propose FGF2 to be a useful prognostic biomarker for proneural glioma patients, bFGF, SD1 and TNF-alpha are significantly reduced in Crohn's disease patients in deep remission under treatment with anti-TNFalpha, likely as an expression of optimal control of inflammation., Gelatin sponges impregnated with more than 100 mug/cm(3) b-FGF incorporating beta-TCP with chondrocytes (10x10(6) cells/cm(3)) can fabricate engineered cartilage at 4 weeks after implantation., with increasing protein concentrations, FGF2 monomers make contacts with each other and form dimers or higher order oligomers. FGF2 purified with ion-exchange chromatography did not show similar perturbation indicating that self-association of FGF2, Knockdown of BAG3 also significantly suppressed motion and invasion of HK2 cells mediated by FGF-2, Alternate protein isoforms arise through the use of AUG and non-AUG (CUG) translation initiation codons., Enforced expression of FGF2 partially reversed the inhibition of cell proliferation., FGF2 overexpression is associated with aggressive pathologic features and worse outcomes after radical cystectomy for squamous cell carcinoma, Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1., The nuclear odyssey of FGF-2 is reflected by nuclear dynamics, localization to nuclear bodies such as nucleoli, binding to chromatin and engagement in various protein interactions. [review], Results support the idea that human striatal precursor cells possess the machinery for their adaptation to hypoxic conditions and that neurotrophic factors, such as FGF2 and ET-1, may sustain neurogenesis and long-term survival, Endostar might exert its anti-tumor effect via suppressing b-FGF-induced angiogenesis and b-FGF-activated MAPK signaling pathway., Report no correlation between serum FGF2 and renal parenchymal scar or grade of reflux nephropathy., JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2., bFGF promotes VEGF expression in chondrosarcoma via c-Src/p38 signal cascade, promoting endothelial progenitor cell-primed angiogenesis., Data show that, depending of its concentration, FGF2 can be either a positive or negative factor of adipogenesis by regulating the ERK signaling pathway providing a mechanistic basis for FGF2 roles in adipogenesis and development of fat tissues., The data suggest that breath condensate of patients with pulmonary hypertension is characterized by increased levels of the angiogenic factors angiogenin, VEGF and bFGF as well as TNF-alpha, but not IL-8., Data suggest that plasma levels of FGF2 are up-regulated and levels of VEGFA (vascular endothelial growth factor A) are down-regulated in type 2 diabetes mellitus (T2DM) patients with diabetic foot (DF) as compared to T2DM patients but without DF., miR-203 inhibits of renal cancer cell proliferation, migration and invasion by post-transcriptionally targeting FGF2., The FGF2-binding peptide derivative P32 has improved stability, is relatively safe, and may have therapeutic potential in FGF2-driven gastric cancer., the main physiological effect of bFGF on myoblast migration is chemokinesis; changes in the surrounding ECM, resulting from aging and/or disease may impact muscle regeneration by altering myoblast migration and proliferation, Macrophage-secreted FGF-2 suppresses M. avium proliferation through various ways including cytokine production, enhancement of phagocytosis as well as oxygen/nitrogen metabolism., This study reveals a novel role for the ERK5-MEF2 cascade, linking bFGF-induced PAI-1 expression and subsequent mitogenic processes in lung fibroblasts., Some valve interstitial cell and some valve endothelial cells expressed FGF2 in valve tissue and this expression was increased in calcified valves., FGF2 nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells, bFGF Promotes the Migration of Human Dermal Fibroblasts under Diabetic Conditions through Reactive Oxygen Species Production via the PI3K/Akt-Rac1- JNK Pathways., these multifaceted effects of FGF-2 promote new tissue formation at the early regeneration phase., FGF2, considered to be primarily catabolic in articular cartilage, is not downregulated as ARGS concentration declines over time since injury, FGF-2 affects the mRNA and protein expression of Runx2, but not the osteocalcin protein level., These studies identify nuclear bFGF as a protein in a subset of TN breast cancers that likely contributes to drug resistance following standard chemotherapy treatment., LTBP-2 is a potent inhibitor of FGF-2 that may influence FGF-2 bioactivity during wound repair particularly in fibrotic tissues., circulating FGF-2 induces intestinal hemorrhage in mice treated with pentosan polysulfate., Basic fibroblast growth factor (bFGF) recapitulated the effects of the conditioned medium in inducing re-expression of cancer stem cells markers and increasing neurosphere formation ability of differentiated glioblastoma multiforme cells, FGF2 directly affects not only the biological properties of endothelial progenitor cells but also the expression pattern and secretion of numerous chemocytokines to regulate angiogenesis., miR503 significantly decreased the migration and invasion ability of the osteosarcoma cells, which may be mediated by the inhibition of fibroblast growth factor 2., Serum CEA, SCCA and bFGF joint detection improved detection sensitivity in lung cancer and had important reference value for pathological type deduction., ASC proliferation was enhanced by hypoxia. HIF-1a activation, FGF-2 production, and the ERK1/2 and Akt pathway were involved in this regulatory mechanism., Expression of FGF-2, FGFR-2 and FGFR-3 was upregulated in patients with potentially malignant oral lesions serving as biomarkers of malignant transformation to oral squamous cell carcinoma., Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts., The present study is the first to thoroughly assess the enhancement of neural differentiation of bone marrow mesenchymal stem cells following transfection with bFGF and NGF., determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients, FGF specifies hepatic fate at least in large part by inducing expression of NKD1 to transiently suppress the canonical WNT pathway., FGF2 monoclonal antibody inhibited angiogenesis in HUVEC cell cultures., Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf., these data demonstrate that FGF-2 priming enhances the angiogenic potential of SHED through the secretion of both HGF and VEGF., BFGF overexpression is a potential indicator of worse prognosis for patients with operable non-small- and small- cell lung carcinomas. (Meta-analysis), FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity, Four FGF2 isoforms result from alternative translation initiation from an AUG and 3 non-AUG (CUG) start codons., A new FGF2 isoform results from the use of a non-AUG (CUG) translation initiation codon.,
OFFICIAL_GENE_SYMBOL FGF2,
SP_COMMENT function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors., miscellaneous:This protein binds heparin more strongly than does aFGF., PTM:Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing., sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon., similarity:Belongs to the heparin-binding growth factors family., subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2., tissue specificity:Expressed in granulosa and cumulus cells.,
fibroblast growth factor receptor 1(FGFR1) fibroblast growth factor receptor 1(FGFR1) Related Genes Homo sapiens
CHROMOSOME 8,
CYTOBAND 8p11.2-p11.1,
ENSEMBL_GENE_ID ENSG00000077782,
GENERIF_SUMMARY vitronectin increased the presence of all four growth factor receptors and most notably, VEGFR-1; in contrast, fibrin decreased all four receptors, especially FGFR-1 and FGFR-2, In the fusion of the FGFR1 and BCR genes in myeloproliferative disorder, it is likely that the dimerization properties of BCR lead to aberrant FGFR1 signaling and neoplastic transformation., distribution in normal endocrine cells and related tumors of the gastroenteropancreatic system; immunoreactive in rare duodenal endocrine cells and in pancreatic A cells, REVIEW; The 8p11 myeloproliferative syndrome is a distinct clinical entity caused by constitutive activation of FGFR1., overexpressed in acute myeloid luekemia while translocations associated with this gene are absent, and more frequently in patients with CD56 immunophenoytpe, Inhibiting expression of bFGF or FGFR-1 in only the melanoma cells is as effective in blocking tumor growth as simultaneously inhibiting bFGF or FGFR-1 synthesis in the melanoma cells and the melanoma cell-interspersing vasculature., CD56 molecules on NK cells interact with fibroblast growth factor receptor 1 on Jurkat T cells to trigger IL-2 production., Review of FGFR1 isoforms and structure-activity analysis [review], Differences in spatial patterns of FGFR expression in normal skin may generate functional diversity in response to FGFs, and in wounded skin FGFs may function in wound healing via induced FGFRs., Our results suggest an autocrine role of the FGF-FGFR-1 system in the pathogenesis of COPD-associated vascular remodeling., Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells., Recombinant FGFR1 was expressed on the surface of Sf9 insect cells. The peptide ValTyrMetSerProPhe can specifically bind to the hydrophobic surface of FGFR1., alternatively spliced FGFR-1 isoforms induce differential signal transduction pathways, ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors., FGFR1 tyrosine phosphorylation is inhibited by sef protein, cAMP-induced nuclear accumulation of FGFR1 provides a signal that triggers molecular events leading to neuronal differentiation of neuronal progenitor cells, FGFR1 has a role in autosomal dominant Kallmann syndrome, expression system is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint, TSH stimulates FGFR1 but not FGF-2 expression and PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators so increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis., Results describe a direct interaction between neural cell adhesion molecule (fibronectin type III [F3] modules 1 and 2) and fibroblast growth factor receptor R1 (Ig modules 2 and 3) by surface plasmon resonance analysis., HFGFR1 was expressed primarily in the ventricular zone embryologically, Tyrosine 463 is phosphorylated and able to transduce signals in response to FGF-2 treatment alone. Furthermore, FGFR-1 dimerization/kinase activation is stabilized by heparin., involvement of a nuclear matrix bound FGFR1 in transcriptional and RNA processing events in the cell nucleus, Here we show that the TCR and fibroblast growth factor receptors co-localize during combined stimulation [which] synergistically enhances the activation of nuclear factors of activated T cells., two novel intragenic FGFR1 mutations in two sporadic male cases in Kallmann syndrome, The weak binding affinity of the fibroblast growth factor receptor (FGFR) 1 interaction with heparin suggests that in this model, FGFR and heparan sulfate proteoglycan are unbound in the absence of FGF ligand on the cell surface., Results suggest that active fibroblast growth factor receptor 1 kinase regulates the functions of nuclear 90-kDa ribosomal S6 kinase., Although FGFR-1 dimerization achieved by fgfr-2 injection led to highly differentiated and smaller bladder tumors, no sign of reduction of tumor angiogenesis was observed, thus suggesting that endothelial cells are resistant to FGF., fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1, insulin receptor substrate-4 and ShcA have roles in signaling by the fibroblast growth factor receptor, conjoint endocytosis and trafficking is a novel mechanism for the coregulation of E-cadherin and FGFR1 during cell signaling and morphogenesis, The reciprocal relationship in gene expression between FGFR1 and FGFR3 in colorectal tissue plays an important role in the progression of the carcinomas to malignancy., Recruitment of SRC to FRS2 leads to activation of signal attenuation pathways., the reversal of hypogonadotropic hypogonadism in a proband carrying an FGFR1 mutation suggests a role of FGFR1 beyond embryonic GnRH neuron migration, and a loss of function mutation in the FGFR1 gene causing delayed puberty., In 'undifferentiated' neurospheres of embryonic brain and spinal cord, transcripts from FGFR1 and FGFR2 were consistently detected., Fibroblast growth factor trophic signaling to differentiated neurons could involve the release of astrocytic basic FGF acting on neuronal FGFR1 expression., FGFR-1 is expressed in early hematopoietic/endothelial precursor cells, as well as in a subpool of endothelial cells in tumor vessels, and that it is critical for hematopoietic but not for vascular development, When used individually, FGFR1 partially prevented goiter and sVEGFR1 partially reduced vascular volume., The interaction of FGFR1 with CREB binding protein allows activation of gene transcription and may play a role in cell differentiation., involvement of a nuclear matrix bound FGFR1 in transcriptional and RNA processing events in the cell nucleus, Data indicate that after endocytosis, fibroblast growth factor receptor (FGFR)4 and its bound ligand, FGF1, are sorted mainly to the recycling compartment, whereas FGFR1-3 with ligand are sorted mainly to degradation in the lysosomes., Two somatic mutations in kinase domain found in glioblastomas (N546K, R576W)., Stimulation of FGFR-1 results in a Ca2+ channel-independent change of gene expression in retinal pigment epithelial cells., data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer, the initial stimulus for renal inflammation, whether immune complex, hypersensitivity or rejection, did not alter expression patterns of FGF-1 or its receptor, FGF-receptor-mediated mitogen-activated protein kinase stimulation is potentiated in cells costimulated with ephrin-A1, up-regulation of the secreted FGF-BP1 protein during initiation of pancreas and colon neoplasia could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions, The activation of FGF-2/FGFR1beta supports progression and chemoresistance in subsets of AML. Therefore, FGFR1 targeting may be of therapeutic benefit in subsets of AML., Mutations leading to FGFR1 loss-of-function were found., These results suggest that constitutive levels of both FGFR1 and FGFR3, but not FGFR4 are essential for FGF-stimulated anchorage-independent growth of SW-13 cells., Paediatric phenotypic expression of FGFR1 loss of function mutations is highly variable, the severity of the oro-facial malformations at birth does not predict gonadotropic function at the puberty., Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes., Analysis of FGFR1 protein revealed that a high FGFR1 gene expression is a distinct molecular feature of early OSCC indicating a participation in initial oral carcinogenesis., analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors, Data suggest that the relative concentrations of Anosmin-1 and FGF-2 modulate the migration of oligodendrocyte precursors during development through their interaction with FGFR1., Immunohistochemical expression of FGFR1 in tumors was confirmed by real-time polymerase chain reaction., FGFR1 signaling contributes to the survival of MDA-MB-134 cells., Identification of 15 new FGFR1 sequence variants in 17 patients with Kallman Syndrome., PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation, Data suggest that preferential premolar agenesis is associated with FGFR and IRF6., FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate, results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4., ZNF198-FGFR1 activated both the AKT and mitogen activated protein kinase (MAPK) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT target FOXO3a at T32 and BAD at S112, respectively., FGFR1 has a role in preventing progression of breast neoplasms, no evidence that mosaicism for mutations, normally associated with syndromal forms of craniosynostosis, occur in single suture craniosynostosis, FGF receptor 1 (FGFR1), which is expressed mainly in neoplastic thyroid cells, propagates MAPK activation and promotes tumor progression. In contrast, FGFR2 is down-regulated in neoplastic thyroid cells through DNA promoter methylation., analysis of EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases, data suggest an important role for FGFR1 and FGFR1-downstream genes in rhabdomyosarcoma (RMS) tumorigenesis and a possible association with the deregulation of proliferation and differentiation of skeletal myoblasts in RMS, FGF and FGFR may have a role in cleft lip and cleft palate, Current evidence supports a heparan sulphate -dependent interaction between anosmin-1 and FGFR1, where anosmin-1 serves as a co-ligand activator enhancing the signal activity. (Review), the involvement of FGFR-1 through FGF2 in eliciting PGE(2) angiogenic responses, Molecular analyses in salivary gland tumors revealed that ring formation consistently generated novel FGFR1-PLAG1 gene fusions in which the 5'-part of FGFR1 is linked to the coding sequence of PLAG1, KAL1 mutations result in a more severe reproductive phenotype than FGFR1/KAL2 mutations., Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1, No sequence variation was found, indicating that mutations in the "hot spot" exons are not associated with nonsynostotic plagiocephaly., In human uterine leiomyomas, FGFR1 were also overexpressed., p38alpha MAPK has a critical role in the regulated translocation of exogenous FGF1 into the cytosol/nucleus, 12% of Kallman syndrome males have KAL1 deletions, but intragenic deletions of the FGFR1, GNRH1, GNRHR, GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome., Identification of two previously unreported SNPs in FGFR1 and FABP3 associated with BMD and a third SNP in TIMP2 related to risk for non-vertebral osteoporotic fractures., fibroblast growth factor receptor 1 ubiquitination is required for its intracellular sorting but not for its endocytosis, BRCA2-associated cancers were characterized by the higher relative expression of FGF1 and FGFR2, FGFR1-IIIb and FGFR1-IIIc are coexpressed, and the FGFR1-III isoforms are differentially regulated by growth factors and cyclin D1., the FGF binding domain and the heparin binding domain are necessary for the hBP3 interaction with endogenous FGF and the activation of FGFR signaling in vivo, Temporal-mediatd FGFR1 indepepndence, no mutations found in Kallmann syndrome, These results indicate that EphA4 plays an important role in malignant phenotypes of glioblastoma by enhancing cell proliferation and migration through accelerating a canonical FGFR signaling pathway., bFGF, FGFR1, and FGFR2 are frequently overexpressed in squamous cell carcinoma and adenocarcinoma of the lung and may have a role in neoplasm pathogenesis, Fibroblast growth factor receptor 1 activity is required for FGF-1 stimulated cell proliferation and priming in early adipogenic events., Overexpression of the FGFR-1 gene may thus be a useful predictor of liver metastasis in patients with colorectal cancer., FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS., Signaling of transgenic Fgfr1 and Fgfr2 is important for their potential ability to mediate axon-glial interaction in the peripheral sensory pain pathway, via influencing myelinating and nonmyelinating Schwann cell function., sequential autophosphorylation of five tyrosines in the FGFR1 kinase domain is under kinetic control, mediated by both the amino acid sequence surrounding the tyrosines and their locations within the kinase structure, Results show the transforming activity of FGFR1 in mammary epithelial cells and identify RSK as a critical component of FGFR1 signaling in lobular carcinomas., Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53., FGFR1 has significant effects on urothelial cell phenotype and may represent a useful therapeutic target in some cases of urothelial carcinoma., that the main role of heparin in FGF-induced signaling is to protect this naturally unstable protein against heat and/or proteolytic degradation and heparin is not essential for a direct FGF1-FGFR interaction and receptor activation, ZNF198-FGFR1 is associated with phosphorylation of several proteins including SSBP2, ABL, FLJ14235, CALM and TRIM4 proteins., monoclonal antibody analysis of multiple FGFR1 isoforms, generated by alternative splicing and post-translational modifications through glycosylation, Study describes the crystal structure of the activated tyrosine kinase domain of FGFR1 in complex with a phospholipase Cgamma fragment., a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development, binding of anosmin-1 to FGFR1 and heparin can play a dual role in assembly and activity of the ternary FGFR1.FGF2.heparin complex., There was no association among gene FGFR1 rs13317, p. E467K, p. M369I, p. S393S and gene FGF10 rs1448037 and nonsyndromic cleft lip with or without palate in Chinese population., The aim of this study was to investigate and compare FGFR expression in in vivo embryonic limb development and in vitro chondrogenesis of mesenchymal stem cells., syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1, Loss-of-function mutations in FGFR1 underlie 7% of normosmic idiopathic hypogonadotropic hypogonadism with different degrees of impairment in vitro., Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours., depressed expression of the Klotho-FGFR1 complex in hyperplastic glands underlies the pathogenesis of secondary hyperparathyroidism and its resistance to extremely high FGF23 levels in uremic patients., Data show that oncogenic forms of fibroblast growth factor receptor type 1 inhibit the pyruvate kinase M2 (PKM2) isoform by direct phosphorylation of PKM2 tyrosine residue 105 (Y(105))., Endogenous SPARC expression can be modulated by FGFR1-III isoform expression. Endogenous SPARC expression in PANC-1 cells was increased in FGFR1-IIIb over-expressing cells, but decreased in FGFR1-IIIc over-expressing cells., Loss of FGFR1 signaling provides evidence that extracellular signals regulate not simply the proliferation or survival of radial glial cells, but specifically their progression to intermediate progenitor cells during neurogenesis in vivo., FGFR-1 amplification or protein overexpression in breast cancers may be an indicator for brivanib treatment, where it may have direct anti-proliferative effects in addition to its' anti-angiogenic effects., Studies indicate communication between tumor cells and their microenvironment is through polypeptide growth factors EGF, FGF, PDGF and receptors for these growth factors., Decreased expression of alpha-Klotho and FGFR1c in parallel with CaR expression and parathyroid cell growth may be involved in the pathogenesis of secondary hyperparathyroidism, brivanib is a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases, Recent advances in interactions of Kallman Syndrome (KS)-associated molecules within the FGFR1 signalling complex are covered in this review, and linkage of autosomal dominant and sex-linked modes of inheritance are discussed [review], Data suggest that amplification and overexpression of FGFR1 may be a major contributor to poor prognosis in luminal-type breast cancers, driving anchorage-independent proliferation and endocrine therapy resistance., Mutations of FGFR1 underlie an autosomal dominant form of Kallmann syndrome., amplified FGFR expression engages the STAT3 pathway, Role of FGFR1 mutations in Kallmann syndrome (Review), Based on our results, it is possible that a subtle dysfunction (expression) of the FGFR1 gene is involved in the development of the most common male reproductive tract disorder - unilateral or bilateral cryptorchidism, the phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR, Dental agenesis may be a clinical feature of Kallmann syndrome caused by a mutation in the FGFR1 gene., The bFGF-FGFR1-PI3K-Rac1 pathway in the bone microenvironment may have a significant role in the invasion and metastasis of Ewing sarcoma., FGFR1 expression levels in parathyroid glands were found to be positively correlated to renal function and significantly decreased over chronic kidney disase stages., Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1., Data suggest that an FGFR1alpha-to-FGFR1beta isoform switch and increased FGF1-induced activation of FGFR1beta may result in a proliferative advantage that plays a key role during bladder tumor progression., Grb14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma, Focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients., FGFR1 is highly expressed in renal cell carcinoma patients, we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line., FGFR1 is a novel obesity gene that may promote obesity by influencing adipose tissue and the hypothalamic control of appetite., FGF signaling, through cooperation between Fgfr1 and Fgfr2 (but not Fgfr3), is required for initial generation of oligodendrocyte precursors in transgenic mouse ventral forebrain, with Fgfr1 being a stronger inducer than Fgfr2., amitriptyline-induced FGFR activation might occur by the MMP-dependent shedding of FGFR ligands, such as FGF-2, thus resulting in GDNF production, Fgfr1/2 are expressed by bone-derived mesenchymal stem cells in vivo and in vitro and are developmentally regulated during their differentiation., homodimerization of FGFR1 appear to be a fundamental mechanism for the agonist activity of all FGF ligands at least in the case of the MAPK signaling., Case Report, These studies show that FGFR1 amplification is common in squamous cell lung cancer, and that FGFR1 may represent a promising therapeutic target in non-small cell lung cancer., Comprehensive mutation analysis of all 7 known KS genes (KAL1, FGFR1, FGF8, PROK2, PROKR2, CHD7, and WDR11) in 30 well-phenotyped probands revealed mutations in KAL1 (3 men) and FGFR1 (all 5 women vs. 4/25 men), but not in other genes in Finland patients., Data show that the majority of TN cell lines only modest sensitive to FGFR inhibition in growth but were highly sensitive in anchorage-independent conditions., These results point to NCAM-mediated stimulation of FGFR as a novel mechanism underlying epithelial ovarian carcinoma malignancy and indicate that this interplay may represent a valuable therapeutic target., Nedd4-1 binds directly to and ubiquitylates activated FGFR1, by interacting primarily via its WW3 domain with a novel non-canonical sequence on FGFR1, regulating endocytosis & signalling during neuronal differentiation & embryonic development., Data indicate that clathrin-mediated endocytosis is required for efficient internalization and downregulation of FGFR1 while FGFR3, however, is internalized by both clathrin-dependent and clathrin-independent mechanisms., FGFR1 is the major mediator with the degenerative potential in the presence of FGF-2 in human adult articular chondrocytes, inductiion of mammary tumorigenesis requires activation of the epidermal growth factor receptor, MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1., Levels of FGF2 and FGFR1 in saliva and serum from patients with salivary gland tumors were significantly higher than those from healthy control subjects suggesting their potential use as cancer biomarkers., For the first time, our gene expression profiling experiment on archival tumour materials has identified upregulated FGFR1 expression to be associated with PC progression to the CR state., LDH-A is tyrosine phosphorylated and activated by FGFR1 in cancer cells., FGFR1 gene rearrangement is associated with systemic mastocytosis and myeloid/lymphoid neoplasm in blast crisis., An increased FGFR1 gene copy number was found in 32 (32%) lung cancer patients, Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766., Deletion of the D1 and the D1-D2 linker (the D1/linker region) from FGFR1c led to beta-Klotho-independent receptor activation by FGF21, suggesting that there may be a direct interaction between FGF21 and the D1/linker region-deficient FGFR1c., genetic association studies in 103 patients from US and UK, The expression of FGFR1 in patients' biopsies may serve as a marker of response to chemoradiotherapy., Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB., FGFR1 amplification is a common genetic event occurring at a frequency of 16% in L-SCCs. Moreover, lymph node metastases derived from FGFR1-amplified L-SCCs also exhibit FGFR1 amplification., INFS/Nurr1 nuclear partnership provides a novel mechanism for TH gene regulation in mDA neurons and a potential therapeutic target in neurodevelopmental and neurodegenerative disorders., KLB and FGFR1 form a 1, FGFR1 initiates MAPK signaling, whereas S4-dependent FGFR1 macropinocytosis modulates the kinetics of MAPK activation, Targeting FGFR signaling is a promising new approach to treating aggressive prostate cancer, There were no significant associations between FGFR1 and clinicopathological parameters in lung cancer, FGFR1 localized to the nucleus specifically in invading cells in both clinical material and a three-dimensional model of breast cancer, proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs, Conclude that FGFR1 amplification is one of the most frequent therapeutically tractable genetic lesions in pulmonary carcinomas., FGFR1 activation in urothelial carcinoma cell lines promotes epithelial-mesenchymal transition via coordinated activation of multiple signalling pathways and by promoting activation of prostaglandin synthesis., The data shows that patients with congenital hypogonadotropic hypogonadism and a splice-site mutation in FGFR1 can undergo reversal., Mutations in FGFR1 gene is associated with the development of myeloid and lymphoid malignancies., results of the present study suggest that MUC4 promotes invasion and metastasis by FGFR1 stabilization through the N-cadherin upregulation., study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity, The novel findings reported in this study are expected to provide valuable clues toward a complete understanding of the other genetic diseases linked to mutations in the FGFR., FGFR1 is amplified during the progression of in situ to invasive breast carcinoma., Report recycling/degradation pathways of FRG receptor 1 in human glioma cell line., Nectin-1 Ig3 induced phosphorylation of FGFR1c in the same manner as the whole nectin-1 ectodomain, and promoted survival of cerebellar granule neurons induced to undergo apoptosis., ErbB3 but not Fgfr1 mRNA levels are reduced in leukocytes of patients with major depressive disorders compared to healthy subjects., Fibroblast growth factor receptor 1 activation leads to induction of CX3CL1 in a tumor setting., FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length., The incidence of FGFR1 amplification within Chinese patient non-small cell lung carcinoma tumors was 6 of 48 squamous origin and 5 of 76 adenocarcinoma., demonstrate skeletal phenotypic characterization of patients presenting with Kallmann syndrome and FGFR1 mutations, FGFR1 amplification is associated with squamous cell carcinoma of the lung., A novel mRNA in-frame fusion between exon 4 of the breakpoint cluster region (BCR) gene at chromosome 22q11 and exon 9 of FGFR1 gene on chromosome 8p11-12 was identified by reverse transcription polymerase chain reaction, Data indicate that FGFR1 amplification is an independent negative prognostic factor in surgically resected squamous cell carcinoma of the lung (SCCL) and is associated with cigarette smoking in a dose-dependent manner., Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer., 2 patients with congenital isolated hypogonadotropic hypogonadism were found to have mutations in FGFR1 (R254W and R254Q); both are loss-of-function mutations demonstrated by their reduced overall and cell surface expression suggesting a deleterious effect on receptor folding and stability, Upregulation of FGFR1 is associated with gastric cancer., The role of the FGFR/klotho-axis remains still unclear in primary hyperparathyroidism., the combination of dovitinib + NVP-BEZ235 or dovitinib + AEE788 results in strong inhibition of tumor growth and a block in metastatic spread. Only these combinations strongly down-regulate the FGFR/FRS2/Erk and PI3K/Akt/mTOR signaling pathways, In Thai Pfeiffer syndrome patients, FGFR1 mutations in exon 5 were identified., FGFR1 amplification is much more common in squamous cell lung cancers (21%) than in lung adenocarcinoma (3.4%). Survival of FGFR1-amplified lung cancer cell lines was additionally shown to be dependent on overexpression of the FGFR1 kinase., Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC, data demonstrate that FGFR1 and FGFR3 have largely non-overlapping roles in regulating invasion/metastasis and proliferation in distinct "mesenchymal" and "epithelial" subsets of human BC cells, FGF2 -FGFR1 activation through an autocrine loop is a novel mechanism of acquired resistance to EGFR-tyrosine kinase inhibitors., Growth inhibition induced by ponatinib was associated with inactivation of FGFR1 and its downstream targets., Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation., KLF10 is an effective repressor of myoblast proliferation and represses FGFR1 promoter activity in these cells via an Sp1 binding site., B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1, Our data identify fibroblast growth factor receptor 1 amplification as a frequent event in primary and metastatic head and neck squamous cell carcinoma and represents a potential biomarker for more aggressive disease., The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients., CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models, High FGFR1 gene copy number is a common finding in SCC and LCC and is an independent favourable prognostic factor., The FGFR1-amplified pancreatic carcinoma cell line PT45P1 showed high levels of FGFR1 mRNA and protein expression., Identified a novel FGFR1 mutation in six out of seven Harstfield syndrome patients., Network models inferred from the data revealed a conserved set of signaling pathways and RTK-specific features that grouped the RTKs into three distinct classes, In this study, we provide evidence that 5% of Small-cell lung cancer cases show targetable high-level FGFR1 amplification, FGFR1 amplification was found in subsets of sinonasal squamous cell carcinoma (20%), carcinomas associated with an inverted papilloma (33%), and sinonasal undifferentiated carcinoma (5%)., A significant association of haplotype GTAA in BMP4 (p = 0.01) and FGFR1 rs13317 (p = 0.005) with NU could be observed., Studies demonstrate that FGFR1 signaling mediates the continuation of MSC growth and establishes a receptor target for enhancing the expansion of mesenchymal progenitors while maintaining their multilineage potential., downregulation of miR-214 in HCC and the upregulation of its target gene FGFR-1 is associated with hepatocellular carcinoma progression, Mechanistic insights into the S100B-FGF2 complex interface and cell-based assay studies involving mutants led us to conclude the novel role of S100B in FGF2 mediated FGFR1 receptor inactivation., Fibroblast growth factor receptor 1 gene locus amplification is associated with lung squamous cell carcinoma., Of 454 primary colorectal cancers, 24 displayed FGFR1 amplification. Of 99 investigated tumors, 18 revealed membranous activated pFGFR1 protein. FGFR1 mRNA levels were independent of the amplification status or pFGFR1 protein occurrence., Activated RSK2 directly interacts with and phosphorylates FGFR1, thereby modulating receptor signaling through regulation of endocytosis., Taken together, the participation of 5-HT1A and FGFR1 homodimers and recruitment of beta-arrestin2 was demonstrated in the FGFR1-5-HT1A heteroreceptor complexes upon agonist treatments., high level of gene amplifications brain metastases of adenocarcinomas but not in squamous cell carcinomas of the lung, Our cutpoint analysis showed a clear threshold effect for the impact of FGFR1 amplification on patients' survival, which can be used as an initial guide for patient selection in trials assessing efficacy of novel FGFR inhibitors., Increased expression of SOX2 and FGFR1 indicate poor prognosis in small cell lung cancer patients., Amplification of FGFR1 is one of the most frequent candidate targets in lung cancer., FGFR1, WNT, and TGF-beta have roles in signaling of reactive stroma in aggressive prostate adenocarcinomas, Individuals with the derived allele of the rs4647905, We further demonstrated that miR-198 directly targets fibroblast growth factor receptor 1 (FGFR1) in lung cancer cells., FGFR1 overexpression is associated with triple-negative breast cancer., Allele frequency analysis showed significant association between the FGFR1 rs13317 polymorphism and international prostate symptom score., Our findings suggested that FGFR inhibition could delay breast tumor progression, impair lung metastasis and break immunosuppression by effecting on tumor microenvironment, which may provide a promising therapeutic approach for breast cancer patient., Nuclear targeting of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion., Case Report, FGFR1 gene polymorphism is associated with lower rate of developing cleft palate or cleft lip in Iranian patients., Down-regulation of miR-214 expression was correlated with increased FGFR1 expression levels, which may contribute to increased colorectal liver metastasis., Data suggest that fibroblast growth factor receptor type 1 (FGFR1) isoform expression can be used as a predictive biomarker for therapeutic application of its kinase inhibitors., FGFR1 lacking kinase domain inhibits canine and human sarcoma cell growth In Vitro., Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism, Amplification owing to polysomy of chromosome 8, where FGFR1 locates, was observed in small-cell lung cancer., Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease, High FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies., FGFR1 or FGFR2 genotype did not correlate with upper extremity phenotype in Pfeiffer syndrome., Case Report, This study presence of FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle cases., Insulin-induced apoptotic commitment depended on the down-regulation of Erk-1, insulin growth factor-1 receptor (IGF-1R), and fibroblast growth factor receptor-1 (FGFR-1)-mediated signaling., FGFR1 tyrosine kinase fusions are associated with aggressive molecular subtype of non-small cell lung cancer., FGFR1 amplification is common in early-stage squamous cell carcinomas of the lung and is an independent and adverse prognostic marker., FGFR1 amplification is detected in a higher proportion of patients whose tumors revealed a poor response to chemotherapy., study reports on a novel heterozygous FGFR1 mutation in 2 siblings with Hartsfield syndrome; both parents were negative for the sequence variant in FGFR1 gene; this suggests gonadal mosaicism, expression appears to be associated with parathyroid carcinoma in hyperparathyroidism-jaw tumor syndrome, Concomitant FGFR3 mutations and protein overexpression indicate that FGFR3-mediated signalling in these tumours would probably be highly active., Our findings provide evidence for mTORC1 activation and FGFR1 overexpression in human fibrolamellar carcinoma, Autocrine signaling through FGFR1 represents a targetable therapeutic pathway in malignant pleural mesothelioma., results suggest that FGFR1 amplification is associated with smoking history and squamous cell carcinoma histology and might indicate poor prognosis., Fluorescence in situ hybridization analysis revealed no polysomy nor an amplification of the FGFR gene copy number in any case, Studies indicate that the overall survival was significantly worse among patients with fibroblast growth factor receptor FGFR1 and FGFR2 gene amplification, Hearing ability was strongly associated with DNA methylation levels in the promoter regions of several genes, including TCF25, FGFR1, and POLE., FGF signaling mediates a positive feedback loop between prostatce cancer cells and bone cells and that blockade of FGFR1 in osteoblasts partially mediates the antitumor activity of dovitinib., Blockade of FGFR1 by a tyrosine kinase inhibitor impairs growth of malignant pleural mesothelioma cells in vitro and in vivo. Read More, Endothelial cells in human patients with chronic cardiac graft rejection lose FGFR1. FGFR1 is the key regulator of TGFbeta signaling and EndMT development., A three-generation family with five members have a heterozygous FGFR1 p.Pro252Arg mutation and variable expressivity of Pfeiffer syndrome., Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour., FIIN-2 and FIIN-3 are the first inhibitors that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors, kinetics of the interaction between serine/threonine-rich domain of thrombomodulin (rTMD23) and FGFR1 were analysed in umbilical vein endothelial cells, Probands and available family members underwent phenotyping and screening for FGFR1 mutations., Gender, stage, differentiation, ethnicities and test methods have no influence on FGFR1 amplification. FGFR1 amplification trends to correlate with lymph node metastasis and smoking. Whether FGFR1 amplification has effect on survival remains controversial, 5-HT1A autoreceptors are recruited into a FGFR1-5-HT1A heteroreceptor complex in the midbrain raphe 5-HT nerve cells and may develop a novel function, FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients, approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1., Data show that high fibroblast growth factor receptor 1 (FGFR1) amplification had significantly shorter disease-free survival and overall survival than low/no amplification group., We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer, Phosphorylation of FGFR-1, AKT, and ERK1/2 in xenograft specimens was also inhibited by AZD-4547 administration, RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis, Membrane FGFR and intranucelar FGFR/CBP pathways regulate FGF-23 transcription., The 1.65 A resolution crystal structure of AZD4547 bound to the kinase domain of FGFR1 has been determined and reveals extensive drug-protein interactions, Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial., FGFR1 expression in TNBCs is independently prognostic of OS, and H-score of 100 or more FGFR1 immunostaining may define tumors that have treatment potential via FGFR signaling inhibition., Increased expression of FGFR1 (and FRS2alpha) was associated with decreased progression-free survival in metastatic renal cell carcinoma., These results suggested that FGFR1 specifically antagonizes influenza A virus replication, probably by blocking viral entry., ESyt2 and ESyt3, but not ESyt1, interact with activated FGFR1., FGFR1 mRNA or protein expression, rather than FGFR1 CNG as a predictive biomarker for the response to FGFR inhibitors in a subset of patients suffering from HNSCC., FGFR1 protein expression is correlated with FGFR1 mRNA levels and FGFR1 gene copy number in small cell lung cancer., Kallmann syndrome with FGFR1 and KAL1 mutations was detected during fetal life, FGFR1 gene rearrangement is associated with mixed-phenotype acute leukemia., Our results indicated that these five polymorphisms of fibroblast growth factor receptor genes do not play any independent roles in the tumorigenesis and progression of HBV-related HCC in Han Chinese patients., 7%) of cases that were associated with an adverse outcome in Pilocytic Astrocytomas., FGFR1 Gene Copy Number gain was more frequently found (26.5%) than gene amplification (3.8%) and correlated with aggressive clinical behavior in consecutive Colorectal carinoma patients., LMP1-mediated FGFR1 activation contributes to aerobic glycolysis and transformation of epithelial cells, thereby implicating FGF2/FGFR1 signalling activation in the EBV-driven pathogenesis of nasopharyngeal carcinoma., FGFR1 may constitute a promising target for novel therapeutic approaches in Ewing sarcoma., Two novel heterozygous missense mutations in FGFR1 and one novel heterozygous missense mutation in KISS1R, were identified in in Chinese Kallmann Syndrome Males with Cleft Lip/Palate., distributed network of individual contributions from several regions of the kinase structure conspires to hinder Asp-Phe-Gly flip; most important of these is likely to reside in the alphaC-beta4 loop region, Amplification of the FGFR1 gene is a rare but noticeable event that can be found in 2% (6/293) of gastric adenocarcinoma cases and was associated with poor 10-year survival, homodimerization of unliganded FGFR1 is independent of its surface density, Report novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism., The present report shows the molecular mechanism underlying the control of trans-phosphorylation of a critical auto-regulatory site in FGF receptors' catalytic domain., These findings suggest that enhanced integrin alphavbeta3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-beta1-induced EMT in mammary epithelial cells., Data show that silencing of fibroblast growth factor receptors FGFR1 or FGFR2 overcomes resistance to the proto-oncogene proteins c-met (MET) inhibitor., FGF1-FGFR1 axis promotes tongue squamous cell carcinoma metastasis through the epithelial-mesenchymal transition pathway, We therefore suggest that FGFR inhibitors exert their effect by suppressing ERK signaling without feedback activation., We analyzed 11 cases of phosphaturic mesenchymal tumor in this study and found that 4/11 cases exhibited cytoplasmic and membranous staining with strong intensity, and 7/11 exhibited cytoplasmic dot-like staining with moderate to weak intensity., FGFR1 amplification occurs in a relevant subgroup of carcinomas of the esophagus and may play a particular role for development of squamous cell cancers., Results identified a strong association between the abundance of Corynebacterium jeikeium and single nucleotide polymorphisms in the host FLG gene related to epidermal barrier function., determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients, FGFR1 contributes to cell proliferation in osteosarcoma MG63 cells, and FGFR1 mediated cell proliferation may be attributed to the regulation of the cell cycle regulator, CDK1., In this study we report the frequency of FGFR1 and KAT6A involvement in patients with hematological malignancies and 8p11 abnormalities., FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1., Frequency of FGFR1 amplification is similar in squamous cell carcinoma of lung with and without lymph node metastases, FGFR1 protein expression may be a biomarker of ER-positive/HER2-negative primary breast cancer with possible resistance to standard treatment, and may be a useful tool to identify more specific patients who would benefit from FGFR-1 targeted therapy., FGFR1 gene mutation may play a role in the development of craniosynostosis., We identified two recurrent mutations in FGFR1 in individuals with encephalocraniocutaneous lipomatosis, a rare neurocutaneous disorder.,
OFFICIAL_GENE_SYMBOL FGFR1,
OMIM_DISEASE Pfeiffer syndrome, Jackson-Weiss syndrome, Hypogonadotropic hypogonadism 2 with or without anosmia, Osteoglophonic dysplasia, Trigonocephaly 1, Hartsfield syndrome,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow., disease:A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity., disease:A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity., disease:Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function., disease:Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly., disease:Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous., disease:Defects in FGFR1 are the cause of non-syndromic trigonocephaly [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome., disease:Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant., function:Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)., PTM:Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., subunit:Interacts with SHB. Interacts with KLB.,