Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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estrogen receptor 1(ESR1) estrogen receptor 1(ESR1) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6q25.1,
ENSEMBL_GENE_ID ENSG00000091831,
GENERIF_SUMMARY The ligand-binding domain of estrogen receptor alpha has been expressed, purified, and crystallized to yield high amounts of soluble protein, in order to solve the structure in its native form without renaturation or modification steps., ERa but not ERbeta is present in human preadipocytes, Association of a T262C transition in exon 1 of estrogen-receptor-alpha gene with skeletal responsiveness to estrogen in post-menopausal women., To determine whether receptor-induced changes in DNA structure are related to transactivation, we compared the abilities of ER alpha and ER beta to activate transcription and induce distortion and bending in DNA., Estrogen receptors are found in brain areas involved in regulation of food intake. The anorexic effects of estrogen are accentuated by stress, thus that variation in the estrogen receptors may contribute to the genetic susceptibility to AN in females., Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation, mutations targeted to predicted helix in the extreme carboxyl-terminal region alter its response to estradiol and 4-hydroxytamoxifen, expression of estrogen receptor alpha and estrogen receptor beta were studied in leiomyomas and homologous myometrium from women in the proliferative phase of the menstrual cycle and from women treated with a gonadotropin-releasing hormone analogue, Estrogen receptors play a role in the activation of amino acid transport system A by estrogen., patients that progressed to breast cancer showed significantly higher ER-alpha expression in their HUT (hyperplasia of usual type)foci compared with controls, There was strong linkage disequilibrium between the three loci and a significant sex difference was observed in allele (for (TA)(n), PvuII) and genotype (for XbaI) frequencies., Results indicate a weak and transient activation of estrogen receptors by estradiol stimulation that may be enhanced by growth factors., RTA, a negative coregulator for ERalpha was isolated, Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism, role in blood pressure, Mutations of tyrosine 537 in the human estrogen receptor-alpha selectively alter the receptor's affinity for estradiol and the kinetics of the interaction, these results show that although estrogen can up-regulate endogenous PR gene expression in osteoblasts via both ER isoforms, ER-alpha is the predominant inducer, Postmenopausal women with coronary disease who have the ER-alpha IVS1-401 C/C genotype, or several other closely related genotypes, have an augmented response of HDL cholesterol to hormone-replacement therapy., Results show that DNA-102 produced a 36-fold increase in the level of total ER alpha mRNA and a 12-fold increase in the level of mRNA for the F isoform transcribed from the upstream F promoter, and induced a more differentiated osteoblastic phenotype., the extent of AF-2-dependent cofactor recruitment by ERalpha or ERbeta is affected both by ER ligands and estrogen-responsive element sequences, Association of polymorphisms of the oestrogen receptor alpha gene with the age of menarche, Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha, crystal structures of the ER alpha ligand binding domain (LBD) bound to both THC and a fragment of the transcriptional coactivator GRIP1, and the ER beta LBD bound to THC, MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor alpha., Identification of ten exon deleted ERbeta mRNAs in human ovary, breast, uterus and bone tissues, possesses a novel large-scale chromatin unfolding activity when tethered or recruited to DNA, demonstrated that ERalpha but not ERbeta directly interacts with calmodulin, effect on cyclin D1 expression, genetic variants in panic disorder, in addition to the alternative cis-splicing, the hER alpha gene is also subject to natural trans-splicing, estrogen via estrogen receptor 1 directly modulates differentiation of bipotential stromal cells into the osteoblast and adipocyte lineages, causing a lineage shift toward the osteoblast, contribution of genetic polymorphism of oestrogen and androgen receptor (AR) genes in male infertility, ADA3-containing complexes associate with estrogen receptor alpha, PRMT2 is a novel ERalpha coactivator., review of connections and regulation of the human estrogen receptor alpha, tentative findings provide evidence that genetic variation in ESR1 may modify coronary reactivity and LDL oxidation and reflect differences in the early pathogenesis of coronary dysfunction in these healthy young men, Expression of c-erbB-2 in node negative breast cancer does not correlate with estrogen receptor status, predictors of hormone responsiveness, or PCNA expression., The constitutively activated MAP kinase cascade in endometrial cancer cells enhances ERalpha transcriptional activity via the AF1 domain. This activation pathway may be involved in the stimulatory effect of tamoxifen on endometrial cancer., Structural regions (BOX-1 & -2)required for the ability of ERalpha to induce transcription synergistically from tandem ERE sequences are also critical for the interaction of the receptor with the co-regulatory proteins., Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK., These results suggest that the estrogen receptor alpha gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women., We outline additional exons in the genes' 5'- and 3'-untranslated regions, a new polymorphic ER alpha microsatellite and a nested gene., MCF-7 cell line stably expressing GFP-tagged human estrogen receptor-alpha under control of the tetracycline-on system to determine the effect of GFP-ER expression on cell proliferation and expression of endogenous ER and hormone-responsive genes, decrease in estrogen receptor alpha and progesterone receptor A and B concentration in the early phase of first stage labor may play a role in cervical dilation at term, Activation of ER-alpha by estrogen results in tumor progression by stimulating cell growth and invasiveness via acceleration of the expression of matrix metalloproteinases., ERalpha is phosphorylated at Serine 118 in vivo, ER-alpha and its mRNA were detected in both the cytosolic and nuclear compartments of skin fibroblasts., Data show that ER alpha and not ER beta silences caveolin-1/-2 expression in an epigenetic fashion in neuronal cells., leucine 372 may be an important part of the interaction surface on estrogen receptor alpha that is responsible for corepressor binding, differences in the abilities of estrogen receptors alpha and beta to integrate activation functions through functional interactions between amino and carboxyl termini are critical for the transcriptional strength of ER subtypes, Upstream open reading frames regulate the translation of the multiple mRNA variants, both transactivation and down-regulation of estrogen receptor alpha by adrenal androgens increase with aromatase overexpression in transfected MCF7 cells, Lack of association between ESR1 gene polymorphism and Parkinson's disease with dementia., Polymorphic variation of the ER-alpha gene appears to have little effect on the pathogenesis of osteoporosis in men., identification and characterization of a new tissue-specific promoter that is involved in the expression of ER-alpha in the epididymis and in testis, ERalpha and ERbeta make unique contributions to xenoestrogen action in target cells, present data indicate that polymorphism of the estrogen receptor alpha gene and multidrug resistance 3 gene mutation are unlikely to play any significant role in obstetric cholestasis in affected Finnish women, Estrogen receptor-alpha is present in the human growth plate in childhood and adolescence, Single nucleotide polymorphisms of estrogen receptor alpha may have role in pathogenesis of human renal cell carcinoma possible genetic risk in carcinogenesis, Association between the estrogen receptor alpha gene polymorphisms XbaI and PvuII and circulating levels of androstenedione was demonstrated, with the highest levels of the hormone being found in the xx and pp genotypes, as compared to XX or PP genotypes., expression of either ERalpha or beta lowers both basal and stimulated PPARgamma-mediated transactivation, demonstrating that signal cross talk exists bidirectionally between PPARgamma and ER in breast cancer cells, Polymorphic in endometrial cancer, Although 17beta-estradiol and hypoxia induce proteasome-dependent degradation of ERalpha, their effects on transactivation are different, and this may have implications for clinical treatment of mammary tumors., present data indicate that polymorphism of the estrogen receptor alpha and multidrug resistance 3 genes 1712delT mutation are unlikely to play any significant role in obstetric cholestasis in affected Finnish women, ER alpha can physically and functionally couple to the lipid kinase phosphatidylinositol 3-OH kinase (PI3K). This interaction leads to activation of PI3K signaling cascade to Ser/Thr kinase Akt., These results demonstrate a novel pathogenic mechanism whereby mutations in BRCA1, via their interaction with ER-alpha, could promote tumorigenesis through the hormonal regulation of mammary epithelial cell proliferation and impaired VEGF, Transcriptional synergism between a p160 coactivator and this protein depends on the coactivator subtype, the type of estrogen response element, and the promoter context., studies suggest that the cooperative interaction of the estrogen receptor with Fos and Jun proteins helps confer estrogen responsiveness to the endogenous progesterone receptor gene, the binding of different ligands to ESRA influences the A/D-F domain interaction and results in specific functional outcomes, Estrogen receptor alpha gene polymorphisms Pvu II and Xba I influence association between leptin receptor gene polymorphism (Gln223Arg) and bone mineral density in young men., estrogen receptor alpha-mediated transcription is regulated by a direct interaction with protein phosphatase 2A, REVIEW, data indicate that coordinated expression of ERalpha and ERbeta might be necessary for normal estrogen action in myometrium and that estrogen appears a dominant regulator of both receptors in the myometrium, Estrogen receptor alpha binds to different selective estrogen receptor modulators based on the sequence of ERalpha, our results indicate an important role for Mediator, as well as its functional interplay with p300/CBP-SRC, in the enhancement of ERalpha-dependent transcription with chromatin templates, estrogen receptor alpha has a critical amino acid (Asp-538) in helix 12, A novel coregulatory protein, template-activating factor-Ibeta (TAF-Ibeta), is identified, which binds to ERalpha in vitro when the receptor is not complexed with an estrogen response element.[TAF-Ibeta], A truncated estrogen receptor alpha 46-kDa isoform in vascular endothelial cells mediates activation of nitric oxide synthase by estrogen., Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta, a single residue in the ligand-binding domain determines the stereoselectivity of ERalpha, The estrogenic down-regulation of PTP gamma expression in human breast is associated with ER alpha., Data show that liganded ERalpha is a much more potent transcriptional activator than ERbeta with chromatin templates, but not with naked DNA., dinucleotide repeat polymorphism of the ER alpha gene may contribute to specific components of personality., Mechanistic differences in the activation of this protein's and ER beta-dependent gene expression by cAMP signaling pathway(s)., Interaction domains of Smad4 and ERalpha are mapped and shown to be essential for transcriptional repression of ERalpha by Smad4., F domain interactions with nuclear cofactors are required for ERalpha/Sp1 action, Estrogen receptor alpha has a role in rapid, nontranscriptional responses to estrogen in endothelial cells through interacting with phosphatidylinositol 3-kinase., Estrogen receptor and progesterone receptor concentrations and ERalpha transcription levels were not statistically different between ethnic backgrounds.A causative role for these receptors in the ethnic variation of leiomyoma biology seems unlikely, Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha., This protein is expressed and synthesized in the human internal thoracic artery., Association study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder in females., Inhibitory AhR-ERalpha cross talk is linked to a new pathway for degrading ERalpha in which TCDD initially induces formation of a nuclear AhR complex which coordinately recruits ERalpha & the proteasome complex, resulting in degradation of both receptors., 2 domains of PRB, ERID-I and -II, mediate a direct interaction with the ligand-binding domain of ERalpha., REVIEW, The considerable increase in estrogen production during pregnancy may play a role, via the ER-alpha, in the stimulation of cytotrophoblast differentiation & promote function in normal placentae., analysis of isoforms of estrogen receptor alpha, Cyclic turnover of hERalpha permits continuous responses to changes in the concentration of estradiol, Due to alternative splicing, the 46-kDa endothelial cell protein (ER46) is an amino-terminal truncated product of full-length ER alpha (ER66)., study of the equilibrium dissociation constant for homodimerization of ERalpha, ERalpha co-activator caveolin is negatively regulated by the steroid receptor itself, estrogen-induced estrogen receptor degradation serves to control physiological responses in human vascular endothelium by down- regulating estrogen receptor alpha and estrogen receptor beta through different proteasomal uptake mechanisms, estrogens may inhibit thymoma growth via estrogen receptor alpha, and estrogen receptor alpha immunoreactivity may act as a prognostic factor in human thymoma, there are at least ten isoforms of ER alpha mRNA containing different 5'-untranslated regions, exons (A), B, C, D, T1-T2, T1, F-E2, F, E1-E2 and E1, expressed in human, and that these are involved in tissue specific expression of the gene., Mutation of Leu-536 in estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation., During trophoblast differentiation, ER-alpha is associated with a less differentiated state. Asymmetric segregation of ER-alpha may play a role in asymmetric division of estrogen-dependent cells., p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells., Polymorphisms have been determined in the coding region of the human ERalpha gene. It is hypothesized that these polymorphisms are associated with renal cell carcinoma., estrogen receptor-mediated estrogen signalling is modulated by a co-regulatory-like function of activated AhR/Arnt, giving rise to adverse oestrogen-related actions of dioxin-type environmental contaminants, estrogen (E2)-depleted medium in MCF-7 breast cancer cell line results in hypersensitivity to E2 coinciding with elevated levels of estrogen receptor (ER) alpha phosphorylated on Ser118 and MAPK, results indicate that the naturally occurring variant ERDeltaE7 is a dominant negative receptor that, when expressed at high levels relative to wild-type ERs, might have profound effects on several estrogen-dependent functions, ER-alpha gene may have minor effects on bone density variation in the Chinese population., Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells, ESR1 dinucleotide repeat is not associated with premature myocardial infarction or with hyperlipidemia in caucasian women., In women there was an allele dose effect of haplotype "px" and a low number of minisatellite repeats with decreased lumbar spine bone mineral density (BMD) and decreased vertebral bone area., Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner, polymorphisms in the ERalpha gene are associated with radiographic OA of the knee, and in particular with osteophytosis, in both elderly men and elderly women., results suggest that, in MCF-7 breast cancer cells, estrogen receptor (ER) turnover, localization, and activity are maintained by an equilibrium between various phosphorylation pathways, which are differently modulated by ER ligands and protein kinases, Data indicate that serines 104, 106, and 118 are important for ligand-dependent ER dimerization, and that MAP kinase mediated phosphorylation may be important for ER function, in yeast model systems., malignant ovarian epithelial cells demonstrated multiple alterations in the expression of estrogen receptor-alpha, estrogen receptor-beta, progesterone receptor A, and progesterone receptor B, SNCG is required for efficient ER-alpha signaling in brest cancer., Rare polymorphisms at codons 119 and 432 of CYP1B1 gene have higher risk for endometrial cancer, and positive correlations with ERalpha and ERbeta expressions in endometrial cancer., estrogen receptor alpha binds to thymine-DNA glycosylase and potentiates transcription of estrogen-regulated genes, Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins, polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer., Oestrogen-activated ERbeta presents a lower transcriptional activity compared with ERalpha, probably due to structural differences in the AF-1 regions of the receptors. Genistein and daidzein act as weak agonists of the oestrogenic activity via ERalpha., Estrogen receptor alpha was seen in the sebaceous gland., The methylation status of estrogen receptor-alpha is cell specific in cancer cell lines., interaction between estrogen receptor 1 alpha and vitamin D receptor gene polymorphisms leads to increased risk of osteoporotic vertebral fractures in women, largely independent of bone mineral density, ERK7 is a novel regulator of estrogen responsiveness through its control of ER alpha turnover, ER-alpha and vitamin D receptor polymorphisms are related to bone mineral density in pre- and post-menopausal women, Activation of the mitogen activated protein kinase (MAPK) induces ligand-independent coactivation of ERalpha by SRA, ESR1 polymorphism maybe associated with risk of endometrial neoplasms., adrenomedullin may be involved in both normal and malignant tissue growth and because of the correlations with estrogen receptor alpha and beta status, there is evidence that ovarian cancer is endocrine-related, estradiol treatment results in binding to membrane ER-alpha and interaction with a heterodimer containing ErbB2, leading to tyrosine phosphorylation. This results in the activation of PI 3-K and Akt. Akt, in turn, may interact with nuclear ER-alpha, up-regulates the MIS promoter activity under low concentrations of E2, Results of this study indicate that genetic polymorphisms in the ER-alpha gene may play a role in the etiology of breast cancer., estrogen receptor alpha Px haplotype and collagen IA1 s allele may be involved in causing the phenotypic expression of higher circulating levels of parathyroid hormone and higher bone turnover, which may lead to bone loss, ESR1 polymorhism is significantly associated with familial prostate carcinoma risk., ERalpha immunocytochemical expression in AD patients did not differ from that in elderly controls., Subgroup of women with vulvar vestibulitis syndrome who exhibit abnormal estrogen receptor-alpha expression. May be helpful in explaining why some women are resistant to medical treatment, Functional and clinical implications of observed ER alpha distribution in the hypothalamus are discussed in relation to reproduction, autonomic-function, mood, cognition, and neuroprotection in health and disease., Findings show that in endometrial hyperplasia and low-grade endometrioid endometrial carcinoma, coordinate increase in cdc25B and phosphorylated ER-alpha occurs., The Px haplotype of the ER alpha gene is associated with low BMD values in females, as the phenotype is gender dependent (the association was not observed in males., Women homozygous for the T-allele of the PvuII polymorphism of estrogen receptor-alpha gene who are treated with coronary stent implantation have a higher risk of in-stent restenosis than men., data provide an alternative mechanism of LDL receptor gene expression by non-classical estradiol- and tamoxifen-stimulated induction through an ER-alpha/Sp1 complex, Our results reveal an association between a common estrogen receptor genotype, ESR1 c.454-397CC, and increased odds of myocardial infarction., ER ligand and estrogen response element (ERE) sequence work together to regulate in vivo binding of ER to estrogen-responsive promoters., upregulation of VEGF-A expression by 2-Methoxyestradiol is mediated through ER-alpha, qualitative and quantitative analysis and comparison of mRNA ER-alpha and its isoforms concentration profile in endometrial adenocarcinoma and normal endometrium, The findings of key roles for histone deacetylases and nucleosome-remodeling complexes in limiting transcription implies that transcriptional activation is a cyclical process that requires both activating and repressive epigenetic processes., Thus, our findings indicated that TAS-108 acts as a novel estrogen antagonist that recruits co-repressors to ERs without AF-1 activation or prevention of DNA binding., AIB1-Delta3 causes a significant increase in the efficacy of 17beta-estradiol at both estrogen receptor-alpha (ER-alpha) and ER-beta in ovarian, breast and endometrial cancer cell lines, In node-negative primary breasst tumors, IGF-IR positively correlated with ERbeta but not with ERalpha, tumor size or grade., a role for genetic variations in the estrogen receptor alpha gene in determining adult stature in women was demonstrated, differential recruitment of steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors by estrogen receptor-alpha and beta in breast cancer may be central to the response of the tumor to endocrine treatment, transcriptional repression by tamoxifen-bound ER at E-regulated gene promoters involves a dynamic interplay of multiple distinct chromatin-modifying/remodeling complexes, ERalpha and ERbeta are located within the MCF7 cell mitochondrial matrix, ERalpha and ERbeta interaction with their cognate target DNAs require the C-terminal extension and HMGB-1/-2, Tranhcriptional activation of endothelial nitric oxide synthase via estrogen receptor (ER)alpha and ERbeta in human pregnant myometrium., both ER-alpha and ER-beta mRNA are expressed in human mature adipocytes with a large predominance of ER-alpha mRNA, Overexpression of ESRA suppresses gap junctional intercellular communication in endometrial carcinoma cells., Estrogen receptor alpha genotype associations were statistically significant in explaining rate of perimenopausal bone loss and bone turnover., Shc and IGF-1R serve as key elements in the translocation of ERalpha to the cell membrane and in the facilitation of ERalpha-mediated rapid E2 action, ER-alpha has a role in CpG island methylation near the TGA initiation codon of the ER-alpha gene in gastric cancer cell lines, HMGA1 cooperates with either the N- or the C-terminal transcriptional activation domain of the estrogen receptor to stimulate estrogen response element binding and promoter transcriptional activity, Estrogen receptor alpha has a role in human breast cancer [review], estrogen receptor-alpha may have a role in male breast cancer development [review], Polymorphisms in ER-alpha gene can affect breast cancer susceptibility and may be related to other protein expression., direct functional activation of ERalpha is caused by amplification of estrogen signal induced by leptin, Data describe the influence of allelic variations of the vitamin D receptor and estrogen receptor genes on bone mineral density., ER alpha interacts with the p55 regulatory subunit of PI3K, whereas ER beta interacts with Akt1 in spermatozoa, Molecular determinants of Era in the selectivity of 16 alpha-iodoestradiol were studied., human estrogen receptor-alpha functions are modulated by s-palmitoylation, Of the approximately 100 regulated genes we identified, some were stimulated by E2 equally through ERalpha and ERbeta, whereas others were selectively stimulated via ERalpha or ERbeta, No evidence of the ESR1 missense mutation A908G was found in breast carcinomas, epithelial hyperplasias or in breast cancer cell lines studied., ER-/Progesterone receptor- breasst tumors in age > 50. ER+/PR+ status was associated with higher frequency of methylation., nuclear factor-kappaB has a role in mitogen-activated protein kinase-induced estrogen receptor-alpha down-regulation in breast cancer cells, T(4), like E(2), causes phosphorylation by MAPK of nuclear ERalpha at serine-118 in MCF-7 cells and promotes cell proliferation through the ER by a MAPK-dependent pathway., Data identify two peptides that are highly selective for tamoxifen-bound estrogen receptor (ER) alpha or beta, and suggest that these peptides recognize a novel tamoxifen-induced binding surface that is distinct from the agonist-induced AF-2 surface., SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery, ER-alpha genotype may modulate relationship between BMD or rates of bone loss and estrogen levels in men. Bone mass in men with the X or P alleles may be more susceptible to consequences of estrogen deficiency than in men with the xx or pp genotypes., Effect of estrogen was caused through the estrogen receptor subtype alpha., Shift of ERalpha from nucleus to cytoplasm in elderly females with absence of Alzheimer's disease(AD). AD showed more nuclear ERalpha and much stronger AD neuropathology., the transcriptional activity of ERalpha relies on its AF-1 transactivation function in most estrogen target cell types, Male and female AD patients had lower ER alpha and beta densities in CP compared to non-AD patients., role in expression of progesterone receptor B-isoform, When present in pituitary tumors, estrogen receptor-alpha exhibits a high concentration, and is more common in nonfunctioning and invasive adenomas, but absent in ACTH-secreting ones., ER alpha mRNA was increased at 6 days but not at 14 days whilst ER beta mRNA expression was only increased at 14 days with 17 beta estradiol treatment, genetic variation in hormone receptors, in particular the ESR1 gene, may play a role in migraine., ERalpha has a role in tamoxifen induction of maspin by recruiting cofactors to the maspin promoter region, FOXP1 is a potential ER coregulator in human breast carcinoma and may also independently regulate additional important pathways that control the progression of breast cancer, estrogen receptor-alpha regulates metastatic tumor antigen 3 pathway, Data suggest that the exon 3-deleted estrogen receptor (ERDeltaE3) inhibits wild-type ER activity and negatively regulates proliferation of MCF-7 cells., Data show that estrogen receptor (ER)beta was degraded in the presence of 17beta-estradiol, and in contrast to ERalpha, ERbeta degradation was not abolished by inhibitors of the proteasome-mediated protein degradation pathway., estrogen receptor redistribution to the cytoplasm and its interaction with HER2 are important downstream effects of HER2 overexpression, Novel single-nucleotide polymorphism provides a tool for human genetic studies of diseases in the African population., Keratinocytes express ER-alpha. Estradiol up-regulates ER-alpha in keratinocytes & induces their proliferation. The binding of estradiol to ER in keratinocytes has a calculated Bmax of 14.2 fmol/mg of protein, Postmenopausal women who carry ESR1 haplotype 1 (c.454-397 T allele and c.454-351 A allele) have an increased risk of myocardial infarction and ischemic heart disease, independent of known cardiovascular risk factors., ERalpha activated the PAI-1 promoter through a proximal ERE (-427) and possibly additional EREs located within the PAI-1 promoter., estrogen receptor alpha is inhibited by melatonin via a calmodulin pathway, ER alpha exists as dimers, a structural requirement that supports rapid signal transduction and affects cell physiology., ERalpha and ERbeta genes show CpG methylation in breast neoplasms, and CpG methylation of the ERbeta gene seems to play a role in cell proliferation, Era-positive breast cancer cells were identified by gene expression profiling of an intrinsic set of estrogen regulated genes., methylation of the CpG sites inside ERalpha gene promoter F here analyzed may contribute to ERalpha transcriptional control, influencing the tissue specific expression of the gene, Neither the PvuII nor the XbaI polymorphism or haplotypes thereof were associated with the risk of all-cause dementia or Alzheimer's disease. Nondemented women who carried the PvuII p allele or haplotype 'px' had smaller amygdalar volumes on MRI., Data show that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha/progesterone receptor complex to the tetradecanoyl phorbol acetate-responsive element of the gene., AIB1 plays a dual role in regulating ERalpha activity, one in recruiting transcription factors including other coactivators involved in gene activation and the other in regulating ERalpha protein degradation mediated by the ubiquitin-proteosome machinery., there is cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha, These results suggest that ERalpha is the functionally dominant partner in the ERalpha/beta heterodimer., nuclear IRS-1 interacts with ERalpha and that this interaction might influence ERalpha transcriptional activity, In the presence of estradiol ERalpha induced CRH-binding protein promoter activity in a dose-dependent manner., ERalpha transcriptional activity is regulated by XBP-1 through modification of large-scale chromatin unfolding, the agonist activity of tamoxifen-bound ERalpha is enhanced by SRA, which may contribute to tamoxifen resistance, The present study shows that Pvull-Xbal ERalpha gene polymorphism is associated with BMD during childhood., methylation of ESR1 is both age-dependent and tumor differentiation-dependent and age-dependent methylation of ESR1 may represent a mechanism linking aging and prostate cancer, results indicate that the mitochondrial ERs can interact with mtEREs and suggest that they may be directly involved in E2 induction of mtDNA transcription, The genetic variation at the ESR1 locus influences susceptibility to persistent HBV infection in a Chinese population., ESR1 may be a possible risk factor for female or generalized type of vitiligo patients., 17beta estradiol promotes Hela cell survival through ER alpha non-genomic signaling and cell death through ER beta non-genomic signaling, Fibronectin and type IV collagen activate ERalpha AF-1 by the c-Src pathway in breast cancer, DRIP205 coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins, Uterine leiomyomas, myometrium, and endometrium display distinct patterns of estrogen receptor alpha and beta expression., estrogen receptor alpha has a role in regulating an association between exercise and pubertal bone mineral density, results demonstrate that transcriptional adaptor ADA3 protein directly binds to human estrogen receptor alpha and beta and enhances the transcription of estrogen receptor-responsive genes, ERalpha palmitoylation has a role in the receptor localization to the cell membrane and in the regulation of the E2-induced cell proliferation, expression of AP-1-dependent genes is inhibited by the cJun dominant negative; the AP-1 blockade does not affect mRNA ERalpha expression or estrogen induction of estrogen-responsive element activity, The relative binding affinities (RBA) of typical ligands with the alpha-subtype of the human estrogen receptor ligand-binding domain (hERalpha LBD)are calculating their binding energies., The ESR1 gene exerts differential genetic effects on bone mineral density and fracture risk., the context of the lactoferrin gene influences the ERalpha-mediated transcriptional activity., the ERE sequence impacts estradiol-and 4-hydroxytamoxifen-occupied ERalpha interaction with coregulators as measured by transcriptional activity in mammalian cells, The expression of Delta5 variation in uterine carcinoma may provide a mechanism by which tumors could maintain expression of E2-responsive genes in the absence of E2., Studies demonstrate the existence of a variant ER-alpha(var2) protein localized in the nuclei in breast cancer cell lines. Specific binding of 17beta-E2 by these cells suggest the ER-alpha(var2) may act as active receptor., Coronary artery cross-sections were immunostained for Androgen receptor, estrogesn rseceptor alpha, and Estrogen receptor beta and then measured semiquantitatively in each arterial wall., No evidence was found for a relationship between common variants of the ERalpha gene and the CYP17 gene with age at natural menopause., differential expression of AR, ERalpha and ERbeta in dermal papilla of hair follicles, estrogen receptor alpha and beta signalling have roles in the naringenin-induced apoptotic cascade in cancer cells, ESRA signaling complex at the cell membrane was analyzed., striatin is the molecular anchor that localizes ERalpha to the membrane and organizes the ERalpha-eNOS membrane signaling complex, Estrogen receptor alpha mRNA levels were reduced in the basomedial nucleus in major depressive disorder and bipolar disorder., PELP1 functionally interacts with both ERalpha and ERbeta and enhances their transcriptional responses., High levels of ER-alpha in endometrial cancer may inhibit cancer growth by modulating angiogenic factors, thereby limiting the blood supply to the growing tumor., ER alpha and Ki67 might be involved in distinct pathological and molecular features during breast cancer development, abundance and specific localization of estrogen receptors alpha and beta in human term myometrium seems to be independent of its contractile activity which may point to the specific role of those receptors in late pregnancy myometrium, ESRA has a role in modulating IGF-I receptor signaling and function in breast cancer, Loss of estrogen receptor alpha is associated with prostatic tumors, found in nuclei of peripheral cells of sebaceous glands while secretory epithelium of apocrine glands of axilla were negative, Estrogen receptor alpha mRNA and protein in kidney alters with age and shows sex differences., cultured and freshly isolated endometrial endothelial cells each express ER-beta mRNA but not ER-alpha., ER may play a role in the rapid effects of resveratrol in EC and some of the atheroprotective effects of resveratrol may be mediated through rapid activation of ER signaling in EC, PvuII polymorphism and the ER-alpha haplotype may be associated with the bone mineral density at several femur sites in postmenopausal Korean women, Coactivation of ERalpha by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure., ERalpha interacts with Sp1 transcription factor in breast cancer cells., The affinity, specificity and stability of complexes formed between estrogen receptor alpha and estrogen response elements are examined and an alternate mechanism proposed for the various effectors involved in the fine-tuning of gene expression., levels of mER-alpha play a role in the temporal coordination of phosphorylation/dephosphorylation events for the ERKs in breast cancer cells, molecular mechanisms underlying ligand-dependent signaling in the ER/AP-1 pathway, Expressed in primary biliary cirrhosis(PBC) but not in normal subjects. Low ER-alpha in PBC and disappearance in advanced histological stages suggests that estrogenic deficiency could favour evolution toward ductopenia., association of ERalpha gene PvuII polymorphism with PCOS determined, binding to calmodulin is required for normal transcriptional function of ERalpha, Myasthenia gravis (MG) patients showed increased expression of estrogen receptor(ER) alpha on thymocytes and both ER alpha and beta on T cells from peripheral blood mononuclear cells, a partial BRCA1 , Positive immunohistochemical staining for ERalpha of an an adenocarcinoma in a gastric biopsy is diagnostic for metastatic breast carcinoma., This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function., Transfection of wild-type or specifically mutated human ERalpha into sheep cells expressing tranfected COX-1 shows that the AF-1 region within the A-B domains of ER is important for Sp1 activation. Similar domains within AF-1 may bind Sp1 & AP-2., Data suggest that the ER-alpha gene polymorphisms and ER status may have an interactive effect on breast cancer survival., the subnuclear positioning of SMRT is influenced by the ligand-bound ERalpha, and this activity is dependent on the ratio of the co-expressed ERalpha and SMRT, Expression of mRNA for estrogen receptors-alpha and -beta in breast tumors before and after 3-month neoadjuvant hormone therapy with antiestrogen tamoxifen and/or aromatase inhibitors., The activation of ER gene expression by 5-aza-2'-deoxycytidine involves the release of the repressor complex involving various methyl-binding proteins, DNMTs, and HDAC1., ER alpha* 14 TA repeats and the CYP17* A1 allele are associated with an increased risk of endometriosis, Alternative splice variants more ofter seen in Alzheimer disease than in normal mammillary nucleus mrna., expression of ESRA, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast is related to nodule size, hormonal and reproductive features, ARA70 is a coactivator for estrogen receptor alpha (ERalpha) and may represent a functional link between ERalpha/androgen receptor (AR) modulating their cross-talk in models of estrogen signaling in MCF-7 and HeLa cells, Expression of estrogen receptors (ERs)-alpha and -beta analyzed in human fetal ovaries at various gestational ages., regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells, loss of estrogen receptor alpha correlates with increasing malignant transformation of endometrial carcinoma, N-CoR and SMRT play an active role in preventing tamoxifen from stimulating proliferation in breast cancer cells through repression of a subset of target genes involved in ERalpha function and cell proliferation, ERalpha/beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells, Activation of protein kinase C delta by phorbol myristate acetate resulted in activation and nuclear translocation of ERalpha., ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription, The Xba I gene polymorphism of ERalpha gene was associated with breast cancer risk, more significantly in postmenopausal women., Polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women., analysis of estrogen receptor alpha membrane localization and function [review], Estrogen receptor (ER) alpha and beta mRNA levels increased from the first to the second trimester and then decreased until normal term delivery., hsp90 ligands induced an estsrasdiol and MG132-inhibited decrease of both estrogen receptor-alpha and -betas cell content., Valproic acid invokes reversible promoter shutoff of estrogen receeptor alpha., Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased cellular retinoic acid binding protein II expression in MDA-MB-231 cells, Estrogen receptor alphaeffects on SULT2A1 were greater than the stimulation seen in response to steroidogenic factor 1 (SF1)., demonstrate that Smad4 induces apoptosis by regulating Bim splicing as an initial intrinsic signal in ERalpha-positive cells, The association of cryptorchidism with homozygosity for the specific ESR1 haplotype suggests the relevance of genetic susceptibility to estrogenic environmental endocrine disruptors, SF3a p120 potentiated hERalpha-mediated RNA splicing, and notably, the potentiation of RNA splicing by SF3a p120 depended on hER Ser-118 phosphorylation, Our studies suggested that pRb2/p130-complexes bind to the ER-alpha promoter and could be involved in the transcriptional regulation of the ER-alpha gene by altering chromatin structure and DNA methylation pattern., Estrogen receptor alpha codon 594 genotype may influence the development of systemic lupus erythematosus at a younger age, as well as a certain disease clinical pattern., increased estrogen down regulated gene 1 expression results in inhibition of cyclin T1 recruitment and ERalpha DNA binding, Haplotypes may incrast thse risk of anxiety disorder, but not a depressive disorder., MAPK and phosphatidylinositol 3-kinase cascades are involved in the nuclear redistribution of ERalpha by EGF and IGF-I, respectively, and that the activation function-2 domain of ERalpha may be needed for the nuclear redistribution of ERalpha, ERRalpha mRNA increased 2 h post-exercise in skeletal muscle, Sumoylation is a new mechanism modulating ERalpha transcriptional activity and ERalpha dependent cellular response., AHR-mediated transcription, There is differential regulation of estrogen-inducible proteolysis and transcription by the Era N terminus., Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability., Common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women., The association of the estrogen receptor (ER) with the complete nonrepetitive sequence of human chromosomes 21 and 22 by combining chromatin immunoprecipitation (ChIP) with tiled microarrays has been mapped., CHIP promotes ERalpha degradation and attenuates receptor-mediated gene transcription., Age-dependent methylation of the ESR1 Cpg island leads rapidly to silencing of the gene within the cells, and hence the colonic crypt within which it occurs., expression of estrogen receptors alpha and beta do not vary significantly with cancer grade, but expression of the androgen receptor is increased in estrogen receptor negative tissue as well as in grade 2 and grade 3 tumours, HDAC4 regulates ERalpha activity as a N-terminal coregulator., ERalpha directly regulates human suppressor of cytokine signaling 3 promoter activity in human breast cancer cells, role for genetic variations in the ESR1 gene in determining post-menopausal E(2) levels in women, GSK-3 interacts with and phosphorylates ESRalpha and is involved in the regulation of receptor activity, This study suggests that Bst UI polymorphism in ER-alpha gene may be absent or rare in Chinese Han population. Pvu II polymorphism possibly influences the loss of trabecular bone mass in old men., interplay between WT1 and ERalpha in control of IGF-IR gene transcription, ablation of forkhead box A1 expression in MCF-7 cells suppressed ERalpha binding to the prototypic TFF1 promoter, LRH-1 is transcriptionally regulated by the estrogen receptor alpha reinforcing the hypothesis that LRH-1 could exert potential oncogenic effects in breast cancer formation., Data suggest that mutation of the estrogen receptor beta but not alpha is an independent risk marker for premature coronary artery disease., Activation of ERalpha by different phytoestrogens in a breast cancer context; a screening bioassay tool to evaluate the estrogenic activity of extracts of herbs and foods, Bangladeshi natural plant extracts modulate expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy, the differential localization of AR and ER isoforms in human sperm reveals distinct roles of these receptors in the physiology of sperm cells, the ERalpha TA repeat polymorphism has a significant effect on the estrogen responsiveness of lumbar spine bone mineral density after 1 year of hormone replacement therapy in Korean women, The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is not required for human uterine epithelial response to estrogen., ERalpha46 antagonizes the proliferative action of ERalpha66 in MCF7 cells in part by inhibiting ERalpha66 AF-1 activity, There was no evidence to suggest that the TA repeat polymorphism of ERalpha was associated with venous ulceration., The ESR1 c.454-397C and c.454-351G haplotype and longer (TA)n repeats are associated with the extent of coronary artery disease(CAD) in young subjects, independent of the known CAD risk factors., Our study does not support an association of the ER-alpha gene with bone mineral density nor body mass index in the Chinese population., Her-2 expression was inversely related to estrogen and progesterone receptor expression in breast cancer., Phosphorylation of ER-alpha Ser167 is helpful in selecting patients who may benefit from endocrine therapy and is a prognostic marker in metastatic breast cancer., Patients with stage I/II endometriosis show a higher incidence of estrogen receptor alpha alleles with fewer (TA)n repeats (12-15 repeats) compared with controls., At elevated levels, ERalpha activated, but could not repress, known estrogen-responsive genes., the ESR1 c.454-397CC genotype may have a role in stroke, oestrogen receptor alpha gene is linked and/or associated with age of menarche in different ethnic groups, pp and XX genotype of estrogen receptor gene may play a certain role in maintaining bone mineral density., 397T/C and -351A/G polymorphisms of ESR1 or haplotypes based on these polymorphisms are not associated with myocardial infarction in a white population., In patients with endometriosis, epithelial and stromal cells from endometriotic lesions both express significantly higher levels of matrix metalloproteinase 1 and lower levels of ER alpha than corresponding cells in uterine endometrium., Results support a relevant role for the estrogenic pathway, notably the ESR1 gene, in human male reproductive function and advocate a complex trait model for male infertility., The results of this study suggest that the PvuII polymorphism in the ER-alpha, or another mutation in linkage disequilibrium with PvuII, in combination with high E2 levels increases breast cancer risk in postmenopausal women, Results underline the importance of the A/B domain of estrogen receptor alpha in both the differentiating and the neuroprotective effects of estrogens., Data suggest that piceatannol and myricetin may contribute to the estrogenicity of red wine since they transactivate endogenous estrogen receptors alpha, and compete with 17beta-estradiol for binding to estrogen receptors., NFAT3 may play a role in estrogen receptor signaling in breast cancer cells, Data show that estrogen receptor alpha (ERa) reduces levels of peroxisome proliferator-activated receptor alpha (PPARa) in breast cancer cell lines, and that reduction of ERa by sodium butyrate results in an increase in PPARa expression., The study concludes that genetic variations at ER alpha gene locus, perhaps, are associated with BMD in Indian women and may influence some determinant of bone metabolism resulting in accelerated bone loss with age., Data suggested suggested Arg548 may play an important role in ESR1 function in precocious puberty., 14-3-3 sigma expression inversely correlated with estrogen receptor alpha, progesterone receptor and estrogen-responsive finger protein, and positively correlated with myometrial invasion and lymph node metastasis in endometrial adenocarcinoma., The largest so far to screen for the ER-alpha A908G mutation in breast cancer confirms the presence of the mutant in invasive breast tumors., ERbeta influences ERalpha protein levels, Epithelial ovarian carcinoma is mediated by activation of ERalpha-mediated transcription., More than two-thirds of invasive breast cancers showed a high degree of methylation of the ER-beta promoter., The replacement of Asp-351 with lysine (D351K) or leucine (D351 L) completely abolished estrogen-dependent transactivation without affecting estrogen-binding, DNA-binding and homodimerization activities in ERalpha., ESR1 G325C polymorphism is associated with migraine in spain population., The (TA)n repeat polymorphism situated in the promoter region of the ERalpha gene has a significant effect on sperm count., study proposes a new mechanism by which estrogen receptors and retinoic acid receptors regulate BRCA1-mediated DNA repair by means of CBP, MUC1 binds directly to the ERalpha DNA binding domain and stabilizes ERalpha by blocking its ubiquitination and degradation., suppressing p53 function is an important component in the pro-proliferative role of ERalpha, Results show that TAK-778 enhances osteoblast differentiation through an ERalpha-dependent pathway by binding to this receptor and not by increasing the expression of ER., ER1 haplotype does not have a strong effect on the estrogen-induced changes in haemostasis and inflammation risk markers for arterial and venous thrombosis, Data demonstrate that estrogen receptor alpha is a TNFalpha-induced coactivator that becomes a repressor in the presence of estradiol by recruiting GRIP1., The expression of estrogen receptor-alpha had no effect on survival., ERalpha PvuII pp and ERalpha XbaI xx polymorphisms were associated with a nonsignificant elevated risk; associations seemed to be stronger among women with a family history of breast cancer., Acetylation is a modulator of the ligand-dependent gene regulatory activity of ERalpha; conserved lysine residues in ERalpha (Lys266 and Lys268) are the primary targets of p300-mediated acetylation., Women affected by endometriosis with ERalpha polymorphic allele, even if heterozygous, have worse prognosis. ERalpha gene polymorphisms may be included among genetic risk factors for endometriosis., a polymorphism in the estrogen-receptor-signaling pathway increases breast cancer risk, No evidence for estrogen receptor 1 gene polymorphisms in intron 1 and exon 4 with migraine susceptibility., ESR1 gene variants are associated with bronchial hyperresponsiveness and a more rapid lung function decline especially in female subjects., Our data suggest a novel ER subtype-specific neuroprotective action by repressing calpain expression and calpain activity under conditions of a massive Ca2+ influx., Expresssion of estrogen receptor-alpha was reduced in cultured cells compared with whole tissue., The association of 2 ESR1 gene polymorphisms (the XbaI and PvuII sites) with cognitive impairment on the Orientation-Memory-Concentration test in postmenopausal Danish women showed a marginal effect of the XbaI polymorphism., analysis of estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells, vinca alkaloids decrease ERalpha protein levels in the human breast cancer cell line MCF-7, Sp3 and Sp4 cooperatively interact with ERalpha to activate VEGFR2, Carriage of the ESR1 IVS1-397 T/C (PvuII), COMT G158A, and the CYP17A 34T-->C SNPs is not associated with the susceptibility to uterine leiomyoma in a Caucasian population., Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration., ERalpha-mediated repression of hepatic transporters and alterations of bile acid biosynthesis may contribute to development of EE2-induced hepatotoxicity, Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter, The results indicate that estrogen plus overexpressed ERalpha induce LoVo cell apoptosis might mediate through the increase of hTNF-alpha gene expression, which in turn activate caspase-8, -9 and caspase-3 and lead to the DNA fragmentation and apoptosis., overexpressed hER-beta but not hER-alpha may induce caspase-8-mediated apoptosis by increasing the hTNF-alpha gene expression in a ligand-dependent manner in poorly differentiated HA22T cells, BARX2 and estrogen receptor alpha may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression., classical estrogen receptors mediate rapid signals induced by estradiol in these cells, metastasis associated 1 family, member 2 is a repressor of ERalpha activity and that it could represent a new therapeutic target of ERalpha action in human breast tumors, ER/PR/AR-negative cells transfected with AR were killed by DHEAS/AI treatment, providing evidence that AR is responsible for this effect. This provides the first AR-targeted hormonal therapy for ER breast cancer., ERbeta selectivity of OBCP ligands can be attributed to a combination of their interactions with Met-336 in ERbeta and Met-421 in ERalpha, aryl hydrocarbon receptor-ERalpha/Sp1 transcription factor cross talk is due, in part, to enhanced association of aryl hydrocarbon receptor and ERalpha, a 1.8-fold increase in ERalpha mRNA and protein in end-stage human dilated cardiomyopathy (DCM, n=41), as compared with controls (n=25), estrogen receptor alpha expression is downregulated by polyamine analogs in human breast cancer cells, the DLC1-KIBRA interaction is essential for ER transactivation in breast cancer cells, PDI plays a critical role in estrogen responsiveness by functioning as a molecular chaperone and assisting the receptor in differentially regulating target gene expression, upregulation of aromatase combined with downregulation of ERalpha provides a basis for selective action of estradiol produced locally by autocrine or paracrine mechanisms, To test bioactivity of estrogens, human ESRA ws expressed in a genetically modified Saccharomyces cerevisiae strain., Cav-1-deficient mammary acini displayed increased ERalpha levels and enhanced sensitivity toward estrogen-stimulated growth, with specific up-regulation of cyclin D1, Data show that estrogen receptor (ER)-alpha36 is a membrane-based, alternatively spliced variant of hER-alpha66 that acts as a dominant-negative effector of both estrogen-dependent and -independent signaling through hER-alpha66 and ER-beta., estrogen receptor-beta/NFkappaB crosstalk mediates ICI 182,780-regulated gene expression in DU145 prostate cancer cells, The estrogen receptor alpha variant lacking exon 5 inhibits estrogen receptor transactivation in hepatoma cells., There is no significant influence of ER Px haplotype on bone mineral density in Chinese women., The relationship between venous thromboembolism ESR1 polymorphism was consistent with a dominant model in women and a recessive model in men., ESR1 polymorphism is associated with susceptibility to hepatocellular carcinoma with hepatitis B virus carriers., BAF57 is a critical regulator of estrogen receptor function in breast cancer cells, The crystal structure of the ligand-binding domain (LBD) associated with hydroxytamoxifen (HT) was determined to 2.2 A and revealed two molecules of HT bound to the protein., PvuII and XbaI polymorphisms in the ER-alpha gene were associated with the risk of developing microsatellite instability in colorectal cancer patients. The BsmI polymorphism in the VDR gene was linked to the risk of developing colorectal cancer, Longer Tandem Repeats in estrogen receptor alpha is associated with breast cancer, Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females., The prevalence of ER, PR and HER2/neu positivity in breast cancer of Jordanian women is lower than that of the western populations and close to other populations such as the Chinese and the minor ethnic groups of Northern America (African Americans)., specific polymorphisms in the CYP1B1, ESR1, and ESR2 genes may play a role in progression of benign breast disease to breast cancer among Caucasian women, FoxM1 and FoxO3a cooperate to regulate ERalpha gene transcription, ERbeta had diverse effects on gene expression, enhancing or counteracting ERalpha regulation for distinct subsets of estrogen target genes, findings suggest that the rate of bone resorption was influenced by ERalpha genotypes, even though these biochemical differences were not evident in bone mass indices, Both ER alpha and beta could mediate estrogen action in spermatogenetic cells. Presence of short ER-beta form in abnormal germ cells and its disappearance in mature sperm, support estrogen modulation via different ERs during sperm maturation., both ERs were significantly overexpressed in macrophages of women with endometriosis compared with controls, there is an E2-dependent, ER isoform-specific transcriptional activation of the RBBP1 gene, which in part, is explained by the differential activity of ER AF1 and enhancer element binding, ERalpha activation switched smooth muscle cells to a dedifferentiated phenotype and may contribute to plaque instability., A range of ERbeta isoform expression occurs in ERalpha-negative breast tumours., Among the glassy cell carcinoma (GCC) cases, estrogen receptor (ER), progesterone receptor (PR) and Her2/neu were positive in 2 (18.1%), 1 (9.1%) and 5 (45.4%) cases, respectively., Contribution of an autocrine ERBB4/estrogen receptor signaling pathway to tumor growth and therapeutic response should be considered when managing patients with ER-positive breast cancer., the allele frequencies of the exon 1 and the intron 1 of the ESR1 gene did not differ between uterine leiomyoma cases and controls (P = 0.325 and 0.175, respectively), A study evaluating potential associations between single nucleotide polymorphism variants of the estrogen receptor genes ESR1 and ESR2 and circulating estradiol concentrations in women of 4 races/ethnicities is presented., The relationship between ESR1 and ESR2 polymorphisms and bone mineral density in women of 4 races/ethnicities who were premenopausal or in early perimenopause is reported., Increases in levels of phosphorylation at serine may play a key role in the emergence of endocrine resistance in breast cancer., LMP2-associated proteasome is recruited to the entire sequence of ER target genes, implicating a role for the proteasome in both transcription initiation and elongation., ERalpha-truncation mutants indicated that helix-12 and interactions with co-regulators influenced large-scale chromatin modeling., polymorphims of the ER-alpha gene, age, years since menopause and educational level are associated with bone density in postmenopausal Vietnamese women, The association between Akt activation and PR negative expression was observed even in the ER-positive cases, mammalian PHB2 has roles in mitochondria and its nuclear translocation is estrogen receptor-dependent, analysis of estrogen receptor-alpha ligand-selective interdomain conformations, Nuclear ER alpha is enhanced during aging in women, indicating availability of locally synthesized estrogens that may up-regulate ER alpha, by which neuronal metabolism can be augmented in the hippocampus after menopause., Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta., Study in a large series of Chinese patients does not show any association of PvuII and XbaI single nucleotide polymorphisms of ESR alpha with increased risk of having adolescent idiopathic scoliosis., role for hematopoietic PBX-interaction protein-microtubule complex in regulating 17beta-estradiol-ERalpha responses in mammalian cells and discovered an inherent role of microtubules in the action of nuclear receptor, Altered expression of ERalpha and ERbeta in tumors compared with corresponding normal gastric tissues was more common in poorly differentiated adenocarcinomas and related to malignant properties, such as lymph node metastasis., the PvuII polymorphism of EDR-alpha had a very weak association with femoral neck bone mineral density (BMD) whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women, Novel polymorphism in the promoter of a cardiac mRNA splice isoform of ERalpha is associated with left ventricular hypertrophy., Gains in area-adjusted bone mineral content in late pubertal girls are strongly associated with ESR1 polymorphisms, ER alpha down-regulation in the mid-secretory phase, leading to defects in uterine receptivity., ERalpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma., expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1, The present study shows that 17beta-estradiol inhibits the transcriptional and apoptotic activities of the APPct complex by a process involving the interaction of estrogen receptor alpha (ERalpha) with Fe65., Binding and dissociation of full-length steroid receptor coactivator-1a (SRC1a) from full-length estrogen receptor alpha or beta., In an analysis of breast cancer-specific survival up to 5 years, high Ki-67, high p53, and negative ER as well as aneuploidy of the tumour were significant prognostic factors., The expression levels of ER subtypes and AR may be important for the regulation of follicular mesenchymal cells in human scalp., estrogen receptor alpha and beta gene polymorphisms may have a role in deep vein thrombosis, Regions within the F domain of the hERalpha selectively modulate its activity and its interactions with other proteins., Data indicate that in the T47D cancer cell line VACM-1 inhibits growth by attenuating estrogen-dependent/estrogen receptor alpha signaling responses., provide only minor support for the role of the androgen receptor and ESR1 gene in the etiology of breast cancer, estrogen receptor expression is decreased in primary tumors and lymph node metastases of human ductal breast cancer after chemotherapeutic treatment, Reduced ERalpha mRNA levels observed in adipose tissue from obese compared to non-obese women support a role for oestrogen signaling via ERalpha, in control of body weight., Genetic variation in genes involved in steroid biosynthesis, metabolism and signal transduction is reported in Greek patients with cholelithiasis., Data suggest that cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells., ERalpha associated with the ninth intron of the endogenous BARD 1 gene in MCF-7 cells., results support the hypothesis that homozygosity for the specific ESR1 'AGATA' haplotype may increase the susceptibility to the development of male genital abnormalities in response to estrogenic environmental endocrine disruptors, Estrogen Receptor-alpha (ER-alpha) in vaginal wall endothelial cells, smooth muscle cells, and fibrocytes was significantly lower in pre-Menopausal women with Stress Urinary Incontence, ICI182,780 and Ral locally alter the ERalpha ligand binding structure via specific hydrophobic residues of H12 and decrease its transcriptional activity through tighter association with an insoluble nuclear structure., Posttranscriptional regulation of ERalpha by a micro-RNA in the context of breast cancer., There was a highly significant positive association between p27(KIP-1) and estrogen receptor/progesterone receptor (ER/PR) status and with p27(KIP-1) and cyclin D1 expression. A trend between cyclin A and PR status was also identified., IGF-1 induces phosphorylation and an increase of the AP1 complex, which is phosphorylated and binds to the pS2/TFF1 promoter, allowing recruitment of the chromatin remodeling factor Brg1 followed by binding of ERalpha via its interaction with c-Jun, The specific XbaI and PvuII polymorphisms of the Er gene are associated with low bMD at all bMD measurement sites in the bulgarian female population. they might become useful genetic markers in osteoporosis risk assessment in this specific population., Persons with one or two copies of ESR1 PvuII-XbaI haplotype 1 have an increased risk of late AMD (aging-macula disorder), especially of the wet form., The relationship between ESR1 intron variants and type 2 diabetes or end-stage renal disease was studied., ERalpha and ERbeta are inhibitory modifiers of Apc-dependent colon tumorigenesis., FXR is expressed in breast cancer interacts with ER, The ESR1 PvuII and XbaI gene polymorphisms seem to affect lipoprotein metabolism in healthy subjects of peak reproductive age., F promoter of ERalpha activity may be tightly regulated by a dynamic interplay between these two Runx2 sites, with a predominance of negative effect of the Runx2 (a) site., ERalpha splice variants and their age-related changes are brain region-specific, exonic, but not intronic polymorphisms of estrogen receptor alpha gene might intensify the cholesterol lowering effect of raloxifene, the ERalpha cofactor RIZ gene has a prominent effect on bone marrow density(BMD), and the P704 genotype modulates the impact of estradiol on BMD, Common ESR1 polymorphisms are significantly associated with age-related changes in left ventricular structure., There is a significant correlation of Pvu II polymorphism of ER gene with dry eye syndrome in postmenopausal women., Estrogen receptor alpha mRNA copy numbers are not significantly different in tissues that are graded as positive by immunohistochemistry and ligand binding assays., temporomandibular joint(TMJ) osteoarthritis(OA) patients with PX haplotype had higher risk of moderate or severe pain compared to those without the haplotype; suggests ERalpha polymorphism may be associated with pain susceptibility in females with TMJ OA, ESRA is a putative substrate for the BRCA1 ubiquitin ligase., ERalpha mRNA and protein were undetectable in adrenal zona reticularis, zona glomerulosa and medulla during development, Fat mass in 11-yr-old children was related to the rs7757956 ESR1 polymorphism, There was an interaction between lean tissue mass (LTM) and ESRA polymorphisms with respect to their effect on femoral neck bone density in postmenopausal women. Those with TC/CC and AG/GG phenotypes had larger effects on LTM., Alzheimer's disease risk was found affected by interaction between estrogen receptor-alpha and butyrylcholinesterase alleles., This is the first report demonstrating estrogen receptors and progesterone receptors in the smooth muscle cells in smooth muscle metaplasia outside the endometriotic foci of rectovaginal endometriosis., The regulation of STYK1/NOK is achieved independent of ERalpha and suggests further investigation to the relevance of this kinase in breast cancer progression., ESR1 amplification may be a common mechanism in proliferative breast disease and a very early genetic alteration in a large subset of breast cancers., the C/C genotype of the ER alpha Pvu II polymorphism was associated with a modestly reduced risk of prevalent and incident hip osteoarthritis in elderly Caucasian women, ERalpha may be required for estradiol modulation of affective and sexual behavior, respectively., Female, but not male end-stage renal disease patients with the ERalpha Ser10Ser CC genotype had lower prevalence of protein energy wasting, lower serum triglyceride, higher serum albumin and lower hsCRP levels., ESR1 polymorphisms do not play a role in breast cancer risk in Caucasian postmenopausal women., Dominant expression of estrogen receptors in penile tissues of children with hypospadias may be the postnatal finding of disrupted estrogen receptor interaction during intrauterine development of external genitalia., Estrogen receptor alpha (ERalpha) was significantly downregulated in ovarian tissue of patients with ovarian endometriosis, Data show that the induction of the gene regulated in breast cancer 1 (GREB1) is mediated by binding of estrogen receptor alpha to three consensus estrogen response elements spread over approximately 20 kb of upstream flanking sequences., biological function for DBC-1 in the modulation of ERalpha expression and hormone-independent breast cancer cell survival, The ratio ERalpha/ERbeta constitutes one decisive parameters to orientate the transcriptional mechanism of a target gene in the presence of agonist as well as of antagonist ligands., did not observe an association between ESR1 PvuII and XbaI gene polymorphisms and ischemic stroke or any subtype of ischemic stroke, Results show a relationship between the presence of the P allele and higher values of cortical thickness in male subjects, indicating for ERalpha a role in the control of tibial bone geometry., There were significant phytoestrogen interactions with polymorphisms in ESR1 and NR1I2 genes affecting estrone levels; we conclude that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal women., The homozygous T-A haplotype carriers of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms showed an increased risk of severe preeclampsia., AHR (aryl hydrocarbon receptor) agonists induce ERalpha promoter occupancy at AHR target genes through indirect activation of oestrogen receptor alpha(ERalpha), and support a role for ERalpha in AHR transactivation, progesterone and glucocorticoid, but not estrogen receptor mRNA are altered in breast cancer stroma, ESR1 contributes to type 2 diabetes and Cardiovascular Diseases risk via pleiotropic effects, leading to insulin resistance, a poor lipid profile, and obesity, Microarrays performed on 17beta-estradiol or 4OH-tamoxifen (4HT) treated Hs578T ERalpha and ERbeta cells revealed distinct ligand and receptor-dependent patterns of gene regulation, while the induction of ERbetacx did not alter gene expression patterns., Results suggest that a relationship between arterial stiffness and -401T/C or 30T/C polymorphisms in ER-alpha is different between sexes in older humans., estrogen receptor alpha A908G mutation has a role in breast cancer invasiveness, Expression of ERalpha correlates with cytokine production in women with endometriosis., Oral contraceptives may interact with the ESR1 A908G mutant receptor to drive the development of some breast tumors., These results are consistent with previous observations indicating a role of ESR1 genotypes in human infertility and give insight into the complex interactions between genotypes and reproductive behaviours in human populations., The mean intima thicknesses in the three genotype groups were 428+/-298 microm (TT), 494+/-371 microm (CT) and 636+/-436 microm (CC). On average, women with the CC genotype had a thicker coronary intima compared with that of women with the TT genotype, polymorphism of genes involving estrogen-metabolizing pathway, estrogen- biosynthesizing pathway and estrogen receptor pathway may play an important role in the etiology of BRCA1/2 negative breast cancer with hereditary predisposing factors., U2-OS cells were used to study direct interactions between fluorescent fusion proteins of ERalpha and the NF-kappaB subunits p50 and p65., Data indicate that SMRT, in conjunction with gene-specific and cell-dependent factors, is required for positively regulating agonist-dependent ERalpha transcriptional activity., ERalpha interactions with insulin receptor substrate 1 (IRS-1) are direct and involve the ERalpha activation function(AF)-1/DNA-binding domain., IL6 and ESR1 polymorphisms may have a role in breast cancer risk associated with active and passive smoking, Estrogen receptor polymorphisms may be associated with increased risk of developing dysplasia of the hip., Per2, a core clock gene, links the circadian cycle to the ERalpha signaling network., Correlation was observed between promoter methylation and loss of protein expression confirming our hypothesis that promoter methylation is an important mechanism for transcriptional silencing of these genes in breast cancer, Four SNPs in intron 4 of ESR1 showed significantly different genotype and allele distributions between premenstrual dysphoric disorder patients and control subjects., the ERs participate in the transduction of mechanical forces into pro-survival signaling in bone cells, albeit in a ligand-independent manner., GSK-3 is required for E2-induced ERalpha phosphorylation at Ser-118 and full transcriptional activity of the receptor upon E2 stimulation., Expression of the NERKI receptor resulted in the suppression of mRNA levels for AP, col I, OCN, and IGF-I. While E2 increased mRNA levels of AP, OCN, col I, and IGF-I in ER-alpha cells, E2 inhibits col I mRNA levels in the NERKI cells., There may be distinct groups of genes down-regulated by ERalpha. Novel role for ERK phosphorylation at serine 118 in activation function-1 in regulating expression of the set of genes down-regulated by 4-hydroxytamoxifen., GATA-3 as a critical component of the master cell-type-specific transcriptional network including ER alpha and FoxA1 that dictates the phenotype of hormone-dependent breast cancer, Increased expression of estrogen receptor (ER)-beta in ER-alpha-positive breast cancer cells antagonizes a defined group of ER-alpha/estrogen stimulated genes that are involved in cell cycle regulation and DNA replication., Tight nuclear binding of the estrogen-occupied estrogen receptor alpha is predominantly mediated by estrogen receptor alpha-DNA interactions., ERR alpha can be deactivated by the synthetic molecule XCT790. This compound also induces a proteasome degradation of ERR alpha, ERalpha and ERbeta do not express in the levator ani muscle of women., Positive expression of ER alpha in addition to negative expression of estrogen receptor beta proved to be an unfavorable independent prognostic indicator insquamous cell carcinoma of the esophagus, ERbeta was 2.5-fold statistically significantly over expressed in postmenopausal leiomyomas compared to patient matched myometrium (p=0.038), whereas ERalpha and PGR were not significantly differently expressed., CYP2A6 is directly induced by estradiol in an ERalpha-dependent manner, implying a biological role of CYP2A6 in estrogen-, Aberrant methylation of multiple genes (E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT) is involved in gastric carcinogenesis., Physiological postnatal vasculogenesis involves cyclic, E2-regulated bioactivity of bone marrow-derived endothelial progenitor cells, predominantly through the ER alpha., there is a progressive loss of ERalpha cofactor recruitment to the estrogen-dependent pS2 gene and reduced requirement for cofactor expression in acquired endocrine resistant breast cancer, estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs, The collective data indicate that peripheral estrogen receptor alpha-dependent mechanisms determine the shape of in vivo growth hormone secretory bursts and that such mechanisms operate with secretagogue selectivity., ability of estrogen receptor alpha to regulate NS5B was suggested to serve as a potential novel target for anti-hepatitis C virus therapeutics, Polymorphisms at the ESR1 gene are associated with premature ovarian failure., The present study examined whether the estrogenic action of imidazolines and piperazines is associated with a down regulation of ERalpha, as reported for conventional agonists., identify KLF9 as a transcriptional repressor of estrogen receptor alpha signaling, cross-talk among ER-alpha, Snail, and the TGF-beta pathway appears to control critical phenotypic properties of breast cancer cells, These results demonstrate that ER DNA binding is not absolutely required for estrogen to induce breast cancer cell growth., Beta-Catenin was co-immunoprecipitated with ERalpha, indicating that these two proteins form a new signaling complex and transcription factor., These findings suggest that PvuII and XbaI polymorphisms may affect the age at onset of the first stroke and the probability of developing cerebrovascular disease., Ligands caused a robust phenotype, leading to an almost total immobilization of ERalpha, whereas ERbeta retained its mobility., Most adult granulosa cell tumors and Sertoli-Leydig cell tumors share overlapping patterns of expression of ERalpha and PR with each other, but a subset of cases in each tumor category exhibits unique ERalpha/PR immunoprofiles, Several SNPs in the ESR1 and ESR2 genes were associated with risk of developing cognitive impairment. These findings suggest that estrogen receptor genetic variants may play a role in cognitive aging., genetic variation in ER gene may influence blood levels of VCAM-1 in women after the menopause, Estrogen receptor alpha and beta gene polymorphisms are not risk factors for recurrent miscarriage in a Brazilian population., an association for breast cancer risk between short (SS) alleles for the repeat variants of the ESR2 and AR genes was found in women of Greek descent., estrogen receptor-alpha phosphorylation at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients, In addition to the activity of RhoGDI alpha in the cytoplasm, it also influences ER alpha signaling in the nucleus., Our results point to an antiproliferative function of the unliganded ER alpha through its physical interactions with p21(WAF1) that may also explain the favorable prognosis of ER alpha-positive breast cancers., A role for estrogenically regulated LRP16 as an ERalpha coactivator, providing a positive feedback regulatory loop for ERalpha signal transduction., study suggests that age, serum vitamin B-12 concentrations, and the presence of benign or neoplastic lesions are independent determinants of ER promoter methylation in colorectal mucosa, upregulation of ER-alpha and downregulation of ER-beta may represent two discrete molecular events in lobular neoplasia pathogenesis., Data show that the inhibition of NFkappaB by ER is mediated by CBP. ER is recruited to the NFkappaB response element of the MCP-1 and IL-8 promoters and displaces CBP., Estrogen receptor alpha and BRCA1 are specifically targeted for methylation in sporadic breast cancers, ER-alpha gene Pvu II and Xba I polymorphism seemed not potentially influence on BMD and bone turnover markers in the pubertal girls in Beijing, suggesting that it might not be the major genetic factor regarding this population., The effect of chrysin and 7-O-beta-D-glucopyranosylchrysin on estrogen receptor alpha transcription in MCF-7 cells is reported., ER and PR are present in transverse carpal ligament and flexor tendon synovitis, suggesting a role for sex steroid hormones in the pathogenesis of carpal tunnel syndrome., Estrogen receptor alpha and estrogen receptor beta act differently through a non-estrogen response element-mediated pathway and may play different roles in medullary thyroid carcinoma tumor growth and progression., the G2014A polymorphism is associated with the presence of osteoporosis while the TA dinucleotide repeat is not, Short-term exposure of breast cancer cells to 1 nM TCDD suppresses ERalpha protein expression, while chronic exposure for more than 1 year results in the partial re-expression of the receptor., The c.454-397T/T genotype associates with first-ever cerebral hemorrhage(CH), particularly in combination with hypertension. Alterations in ER alpha-mediated signaling may be involved in pathophysiology of CH, with putative impact on primary prevention., The complementary abilities of ER alpha and NM23-H1 together to influence gene expression, cell migration, and apoptosis could be key factors in helping to determine tumor cell fate, Therefore, a loss of cell-cell junctions, a key process that occurs during the epithelial-mesenchymal transition, should have a broad impact on ER alpha transcriptional functions., Strongly positive estrogen receptor is associated with leiomyomas of uterus., BTF3 interacts with ERalpha that has been activated either by 17beta-estradiol (ligand-dependent activation) or by epidermal growth factor (ligand-independent activation)., activation of PKCtheta inhibits the FOXO3a/ERalpha/p27(Kip1) axis that normally maintains an epithelial cell phenotype and induces c-Rel target genes, thereby promoting proliferation, survival, and more invasive breast cancer., Report show that ESR1 expression was appreciably higher in malignant breast cancer tissues compared to benign tissues., ERbeta/ERalpha mRNA was significantly elevated in endometriosis. Expression of PR-C mRNA relative to PR-A and PR-B mRNA was significantly increased in endometriosis., ESR1 gene alleles are unlikely to be a major cause of obesity in women, In our community-based study of elderly, a polymorphism in the estrogen receptor alpha gene was associated with endothelium-dependent vasodilation in resistance, but not conduit arteries, may play an important role in the function of human periodontal ligament fibroblasts., Pituitary and/or peripheral estrogen-receptor alpha regulates follicle-stimulating hormone secretion, whereas central estrogenic pathways direct growth hormone and prolactin secretion in postmenopausal women., this follow-up study confirms previous findings that the ER-alpha PvuII polymorphism (Pp) modulates the association between exercise and bone mass, Data suggest that as cells adapt to chronic estrogen stimulation, estrogen receptor alpha is stabilized by a decreased rate of proteolysis and the accumulation of proteasome-resistant, phosphorylated form of receptor., The ligand-binding domain is produced in Escherichia coli as a cleavable thioredoxin (Trx) fusion in order to improve solubility and the structure determined., Adrenal cortical carcinomas are character- ized by an imbalance between estrogen receptor alpha and estrogen receptor beta levels and increased aromatase expression., loss of p21's cyclin-dependent kinase inhibitory property results in hyperphosphorylation of estrogen receptor-alpha, with subsequent increased gene expression of estrogen receptor-regulated genes, our data suggest that the four analyzed genes do not play an important role in susceptibility to schizophrenia., Immunohistochemical expression of ERalpha seems to decrease in the ovaries of women after menopause., Distribution of ERalpha PvuII and XbaI genotypes in population of Polish postmenopausal women, is evaluated., Estrogen receptor-beta (ERbeta) expression, but not Estrogen receptor alpha, was significantly higher in normal ovarian tissues compared with malignant ovarian tissues, Determine estrogen receptor alpha and beta in uterine fibroids, 17beta-estradiol induces ERRalpha gene expression in MCF-7 cells through active recruitment of co-activators and release of co-repressors when ERRalpha and AP1 bind and ERalpha is tethered to the multiple hormone-response element, Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms were not associated with endometriosis in the population studied., The positive and significant correlations between the number of CD1a+ cells and positivity of the primary tumour for estrogen receptor and progesterone receptor suggest a possible role for CD1a as a prognostic marker for breast cancer., Results show that disease stage, tumor grade, SES, race/ethnicity, negative ER and PR status, rather than negative HER2 status, were risk factors for survival., Polymorphisms in the ESR1 gene are unrelated to open-angle glaucoma, but ESR2 polymorphisms seem to lead to increased risk of OAG in men., BRCA1 exerts its tissue-specific function through the regulation of progesterone receptor and estrogen receptor-alpha., Estrogen receptor alpha, rather than estrogen receptor beta, plays a major role in regulating autoimmunity in (NZB x NZW) mice, and suggests for the first time that estrogen receptor alpha promotes lupus., the ERalpha signalling pathway is disrupted by PPARgamma agonists, In the present review we discuss recent findings showing that, in addition to the canonical estrogen receptor-alpha (ERalpha), the level of various ERalpha splice variants is changed in the human brain in aging and Alzheimer's disease [review], mechanisms of resistance of breast cancer cells to endocrine therapies due to the crosstalk between the ER and the HER growth factor receptor signaling pathways, Hsp22 induction represents a new aspect of the estrogenic response with potential significance for the biology of estrogen receptor-positive breast cancer cells., Different modulation of ERalpha palmitoylation exerted by different ligands represents a pivotal mechanism that drives cancer cell to proliferation or apoptosis., Thus, the perilipin gene expression is regulated by a transcriptional network controlling energy metabolism, substantiating the functional importance of perilipin in the maintenance of body energy balance., Results support a model in which ERalpha/AP-1 complexes modulate F promoter activity under conditions of 17-beta-estradiol stimulation., In conclusion, 17beta-estradiol suppressed OPG production by human breast cancer cell lines in a dose-dependent and specific manner, indicating that the RANKL/OPG cytokine system is an estrogen-responsive target in breast cancer., MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways [review], p53 has a role in preventing centrosome amplification, ERalpha phenotypic heterogeneity and metastasis in breast cancer, Our results do not support a strong association between common variants in the ESR1 and EGF genes and breast cancer risk, tumour characteristics or survival., Data show a relationship between wild-type ER-alpha and level of cognitive impairment in Alzheimer's, and also suggest the possibility that variant isoforms of ER-alpha may be present in frontal cortex of patients with and without AD., a statistically significant relationship between the estrogen receptor type alpha c.454-397T>C polymorphism and coronary artery disease were found independent of known CAD risk factors in a Turkish population., The data demonstrate that, in contrast to mice, no alterations in the expression of androgen and estrogen hormone receptors were evident after surgery in patients., The PvuII T allele may be a germline risk factor for familial forms of breast cancer and is associated with a specific subset of immunohistochemical tumor phenotype., evaluated variants across the entire ESR1 gene for association in African Americans with type 2 diabetes and end stage renal disease, Results reveal that estrogen receeptor alpha signaling is dependent on protein acetylation and epigenetic regulation., We have not been able to replicate the previously reported association between variations in the ESR1 gene and risk of stroke, Higher levels of ERalpha mRNA is associated with bladder transitional cell carcinoma, HER2 and estrogen receptor alpha expression depends upon nuclear localization of Y-box binding protein-1 in human breast cancers, depletion of HDAC2 results in simultaneous depletion of ER and PR, and potentiates the effects of antihormonal therapy in ER-positive cells, ESR1 knock-in anmals are sensitive to diethylstilbestrol-induced inhibition due to upregulaterated utrerine estrogen receptor beta levels., The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve., the T allele of rs2881766 could be a useful genetic marker of PIH. The G-A-T haplotype of rs2881766-rs1643821-rs988328 and the G-A haplotype of rs2881766-rs1643821 appear to be resistance markers of pregnancy-induced hypertension., The multifunctional estrogen receptor-alpha F domain., estrogen, growth factors and cAMP elicit surprisingly distinct ERalpha-dependent transcriptional responses in human MCF7 breast cancer cells, the ERNE-145 genotype alters transcription and is associated with increased HDL, the MAPK stimulation of ERalpha activity involves the phosphorylation not only of S118 but also of S104 and S106; MAPK-mediated hyperphosphorylation of ERalpha at these sites may contribute to resistance to tamoxifen in breast cancer., These findings suggest that the G allele containing variants of ESR1 XbaI and the G allele containing variants of ESR2 2681-4A>G may decrease the risk of hypospadias, whereas the ESR1 C-A haplotype may increase its risk., methylated ESR1 and 14-3-3-sigma may have roles in development of breast cancer, Results show that estrogen receptor alpha genotype may be associated with pelvic organ prolapse risk., K302/303 of ERalpha protect ERalpha from basal degradation and are necessary for efficient E2- and ICI-induced turnover in breast cancer cells, ERa gene polymorphism is associated with hypomenorrhea with unknown etiology., luminal ER(+)PR(+) breast tumors contain a minor ER(-)PR(-)CK5(+) population that has the capacity to generate the majority of ER(+)PR(+)CK18(+)CK5(-) cells, Adenocarcinoma of gallbladder is negative for both ER(alpha) and progesterone receptor., analysis of how ligand dissociation from estrogen receptor is mediated by receptor dimerization, characterization of estrogen receptor expression profile & regulation of ER-alpha during differentiation into osteoclasts; results provide better understanding of role of ER-alpha regulation during bone resorption mediated by osteoclasts, constructed and analysed a multi-step model of hER-induced gene transcription that explains the multiple forms of a simple dose-response curve in an in vitro transcription system, role for estrogen receptor activity in the development of Alzheimer's disease in women with Down syndrome, This is the first report of the essential role of SPOP in ERalpha ubiquitination by the Cullin3-based E3 ubiquitin ligase complex., Suggest that epistatic interactions of ESR1 and ESR2 alleles could be associated with advancing age at menarche among Spanish women., The variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing., The available data indicate a deleterious action of the ESR1 deletion in both male and couple fertility., results suggest a novel B cell-mediated pathophysiological mechanism for the etiology of osteoporosis, which is that downregulation of ESR1 and MAPK3 in B cells regulates secretion of factors leading to altered osteoclastogenesis or osteoblastogenesis, providing a plausible explanation for distinct PGC-1alpha binding to ERRalpha monomers and homodimers, ERalpha protein exists in neurones in mammalian prefrontal cortex., We have discovered common sequence variants that are consistently associated with bone mineral density and with low-trauma fractures in three populations of European descent., female-specific association between ESR1 SNPs and neurobehavioral phenotypes, In youths, evidence of association between rs9322331 & rs9340799 & apoC-II was stronger in males than in females. These findings suggest that ESR1 variation plays an age- and sex-dependent role in determining plasma lipid & apolipoprotein levels., The dose of receptor critically mediates estradiol's ability to regulate growth factors and survival kinases., analysis of a human estrogen receptor alpha mutation with differential responsiveness to nonsteroidal ligands, Crucial role of ER in the regulation of the CA12 gene in breast cancer., SNP12 in ESR1 is not associated with the occurrence of cryptorchidism but is associated with the severity of cryptorchidism., ERalpha (estrogen receptor alpha) expression was present in ten of ten endometrioid adenocarcinomas but in only five of ten serous carcinomas, Results show that estrogen receptor alpha is directly methylated at lysine 302 (K302) by the SET7 methyltransferase., disruption of ERalpha-p53 interaction in vivo resulting in restoration of functional p53 is a cellular response to radiation, TIEG is rapidly induced in response to estrogen in osteoblasts by ERbeta, but not ERalpha, the Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer, estrogen receptor-alpha is activated by the anion nitrite, Data show that the TNF alpha may partly regulate the growth of MCF-7 breast cancer cells through the down-regulation of ER alpha expression, which is primarily mediated by a PI3K/Akt signaling., In North Indian population, ERalpha and CYP19 genes may be playing a role in the risk of prostate cancer., Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors, ER alpha is involved in activation of ERK/mitogen activated protein kinase by genistein by its early association with IGF-IR, leading to hyper-responsiveness of leiomyoma cells, confirming that ER signaling is enhanced by activation of ERK/MAPK., Functional interaction between estrogen receptor(ER)s and adenomatous polyposis coli (APC) shows that APC may physically associate with ER alpha in a ligand-dependent manner and enhance estrogen-dependent transactivation of the estrogen response element., Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase., Homozygous ER-alpha disruption markedly affects bone growth, mineral content, and structure but not periosteal circumference. ER-alpha heterozygosity appears to not impair spine aBMD., All tested ligands repressed the MMP1 promoter through the L540Q mutant with identical efficacy., ERalpha concentrations were low in normal adrenal gland, in adrenal tissues adjacent to adrenocortical ademoma, in carcinoma, and lower in adrenocortical adenoma, Findings suggest that Vav3 overexpression may aberrantly enhance ERalpha-mediated signaling axis and play a role in breast cancer development and/or progression., a combinatorial eNOS/ERalpha complex at the hTERT estrogen response element site and that active eNOS and ligand-activated ERs cooperate in regulating hTERT expression in the endothelium., GATA3 is hypothesized to be integral to the ERalpha pathway, Jab1 is a target of EGFR signaling in ERalpha- cell lines and breast tumors, The co-occupancy of ERalpha and Sp1 on TFF1 promoter remains at similar level with and without estrogen, while that of ERalpha and Sp3 increased in the presence of estrogen, Tamoxifen treatment of breast cancer cells reduced the expression of ER-alpha and increased the expression of SMRT., Phosphorylation of ERalpha Ser118 and ERalpha Ser167 affects survival in ER-positive breast cancer and could be helpful in distinguishing patients who are likely to benefit from endocrine therapy alone from those who are not., These studies demonstrate positive cross talk between ER, c-Src, EGFR, and STAT5b in ER+ breast cancer cells., ER alpha plays a protective role in modulating the induction of DNA damage by E 2 in human breast cancer cells., The mean number of ERA-positive stromal cells was lower in hereditary vs sporadic cancer., ERAP75 functions as a novel coactivator that can modulate ER alpha function in the prostate stromal cells., Data suggest that the aryl hydrocarbon receptor repressor might play a role of co-repressor on the transcriptional activity of the estrogen receptor alpha homodimer., The results of immunoblotting experiments revealed that both estrogen receptor alpha (ESR1) and beta (ESR2) proteins are expressed in nuclei, but not in the cytoplasm of peripheral blood mononuclear cells., Aberrant methylation of ESR1 promoter is associated with acute myeloid leukemia, Data show that RbAp46 and RbAp48 interact with estrogen receptor (ER)alpha at endogenous, estrogen-responsive genes and alter expression of endogenous, ERalpha-activated and -repressed genes in MCF-7 breast cancer cells., Estrogen receptor alpha decreases the DNA binding of NF-kappaB subunits p65 and p50., PvuII gene polymorphisms affect CAD susceptibility in man only. The PvuII CC is a risk factor for CAD and it is associated with angiographic CAD severity., The effect of Etrogen receptor alpha on slug repression is dependent on the overall level of ERalpha, confirming that slug is an estrogen receptor alpha reponsive gene., miR-206 could be a novel candidate for endocrine therapy that targets only ERalpha in breast cancer., Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches., ER- breast cancer cells become dependent on Notch-survivin signaling for their maintenance, in vivo., In summary, our results confirm the stimulation of ER alpha and ER beta on CRH expression and demonstrate the important roles of the ERE half sites and CRE for the action of ER alpha and ER beta., the effects of ring B unsaturated estrogens are mainly mediated via ERbeta and that the presence of both ER subtypes further enhances their activity, A phosphorylated form of the membrane estrogen receptor-alpha was found to characterize the invasive breast cancer state, Variation within the promoter region of ESR1 is associated with the extent of hypertrophy in male hypertrophic cardiomyopathy patients., A significant association was found between necessity of hormone replacement therapy and rs1256049, rs1271572, and D14S1026 in ERbeta and rs2228480 in ERalpha., Genetic polymorphisms of ER-alpha are associated with breast cancer., estrogen/ER-responsive breast cancer genes linked to cell growth and invasion pathways are associated with loss of PR and earlier disease-specific mortality, cyclin D1b protein is aberrantly regulated and could contribute to therapeutic failure in the context of ER-positive breast cancer, estrogen receptor 1, vitamin C receptors SLC23A1 and SLC23A2, and matrix metalloproteinase MMP3 and MMP9 are associated with susceptibility to lymphoma, Effects of estrogen-like compounds on cell proliferation are dependent on the actual ERalpha/ERbeta expression levels in these cells or tissues., Estradiol-induced AKT-dependent phosphorylation of FKHR drives its association with ERalpha, thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry., Hyermethylation of CpG islands in the ER-alpha gene promoter region was found in high frequency in atherosclerosis patients., ERalpha plays important roles in conjugated linoleic acid induced apoptosis in human breast tissues, Results identify single nucleotide polymorphisms that are significantly associated with hip fractures in a Chinese population., ESR1 single nucleotide polymorphisms could have a mild influence on TCI scores in healthy people mainly but also in suicide attempters., The X allele of ERalpha is associated with endometriosis in a Chinese population., erk1 E2, a sex hormone, stimulates MUC5B gene overexpression by interaction with estrogen receptor alpha (ERalpha) and by acting through extracellular signal-regulated kinase 1/2 (ERK1/2)-mitogen-activated protein kinase (MAPK)., Estrogen receptor gene amplification occurs rarely in ovarian cancer., ERalpha46 may be involved in the development and/or progression of colorectal cancer via mediating growth inhibition and apoptosis of cancer cells in the presence of 17beta-oestradiol., This study clearly implicates WT1 as a mediator of antiestrogen resistance in breast cancer through down-regulation of ERalpha expression., ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months of tamoxifen chemoprevention., Significant difference in estrogen receptor expression between high-grade and non-high-grade tumors with bone metastasis suggests that different panels of molecular markers should be used to predict bone metastasis in these 2 groups of tumors., These findings indicate that the activation of hTERT expression and telomerase activity by estradiol in human mesenchymal stem cells depends on ERalpha, but not on ERbeta., ESR1 amplification might be one mechanism for ER over-expression in endometrial carcinoma, and suggest an early role for ESR1 amplification in the development of a significant fraction of endometrial carcinoma., Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer., Altered levels of estrogen receptor (ER) subtypes resulting in an increased ERalpha, distal ER binding sites are bona fide transcriptional enhancers that are involved in long range chromosomal interaction, transcription complex formation, and distinct structural modifications of chromatin across large genomic spans, In breast cancer cases with tumors positive for ER, the proportion of cells positive for ER-alpha was similar post-menopausally and pre-menopausally, The data support that hNOS2A transcription is regulated positively by ESR2 and negatively by ESR1 in VSMC, supporting differential actions of these two estrogen receptors on a physiologically relevant gene in VSMC., 249 mature micro-RNA (miRNA) transcripts were quantified in estrogen receptor-positive (ER(+)) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic capability., Data show that the interleukin-6 -634C/G and estrogen receptor-alpha PvuII polymorphism were significantly associated with bone mineral density accrual and that they have an interactional effect on BMD accrual in Chinese adolescent girls., The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization., Different from ERbeta, p53 interacts with HDAC1 and CtBP1 and forms an inhibiting transcriptional complex that could compete for binding to Sp1 sites with ERalpha transcriptional complex and inhibit BRCA2 transcription more significantly, miR-221 and miR-222 play a significant role in the regulation of ERalpha expression at the protein level and could be potential targets for restoring ERalpha expression and responding to antiestrogen therapy in a subset of breast cancers., ER-alpha transcripts are expressed in human skin dermis, but barely detectable in epidermis or appendages. No site difference between face, arm, or hip. ER-alpha mRNA levels are approximately 10-fold higher than those of ER-beta in human skin., Estrogen alpha and progesterone receptor may have a role in preventing progression of breast cancer, Epigenetic alteration of the ERalpha gene may play an important role in the pathogenesis of breast cancer, ESR1 amplification is not present in our panel of 274 tumors (168 ER-positive cases). Deletion and breaks occurred in the same region, towards the 3 of the ESR1 locus, suggesting that fragility of this region may lead to inactivation of the gene., model for the cell type-specific ERalpha occupancy of epigenetically marked cis-regulatory regions of target genes, A comparison of ERs in tissues taken from gastric tumors and adjacent gastric mucosa revealed a loss of ERbeta and a gain of ERalpha in the tumor cells, ERalpha and ERbeta were generally expressed in the same nuclei in myofibres and in endothelial cells of the capillaries with no sex difference, PR and ERalpha may play a role in the pathogenesis of the maturation arrest and Sertoli cell-only phenotype in patients with infertility, These results suggest a unique role of AKT in modulating estrogen signaling in ERalpha-positive breast cancers and highlights how extracellular signal activated kinases can change the landscape of transcription factor binding to the genome., The results suggest that the Pvull polymorphism of ER-alpha gene as well as Xbal polymorphism may not be linked with appearance and development of breast cancer., Vitamin D receptor allele B and estrogen receptor allele X are susceptible alleles for chronic periodontitis., Short-term oral contraceptives yielded lower ERalpha and PR contents. Postmenopausal estrogen/progestogen combined therapy yielded lower PR content than estrogen-only therapy., ERalpha is involved in the transcriptional regulation of HSD17B8 gene in response to E2 through its interaction with C/EBPbeta., ERalpha-phospho-Ser118 may be important in leiomyoma growth and is possibly phosphorylated by phospho-p44/42 MAPK., The association between type 2 diabetes and ESR1 variants may be because of other unidentified ESR1 polymorphisms that regulate glucose homeostasis., Reactive oxygen species can induce post-translational modifications of ERalpha at serine 118 and serine 167, and may lead to ERalpha down-regulation in human breast cancer cells, Overexpression of ER, Ki-67 and cyclinD1 is associated with carcinogenesis of breast cancer., The influence of ERalpha polymorphism should be taken into account among the negative factors influencing the development of osteoporosis, especially in the case of prolonged lack or minimal physical activity., Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression., Evaluation of p16 and ESR1 promoter methylation in blood using real-time PCR appears to be very useful for lung cancer diagnosis, The different ligand regulations of KRT13 are due to ligand-differential recruitment of ER and coactivators., Findings suggest that the GGGA repeat from ESR1 and the CAG repeat from AR may be associated with risk of late onset prostate cancer., These results point at the importance of the cellular ERalpha/ERbeta ratio for the ultimate effect of (phyto)estrogens on cell proliferation., STEAP1 response to E2 in vitro suggest an effect mediated by the membrane-bound ERalpha (mbERalpha)., A systematic study of posttranslational modifications of the estrogen receptor isolated from the MCF-7 human breast cancer cell line is reported., intronic single nucleotide polymorphism is associated with endometrial risk cancer, Estrogen receptor alpha is expressed in cultured and circulating endothelial progenitor cells during the menstrual cycle., Review focuses on the critical aspect of the insulin/insulin-like growth factor I (IGF-I) network involved in crosstalk with ERalpha and implicated in breast cancer development and progression., decreased BRCA1 levels modify ERalpha-mediated transcription and regulation of cell proliferation in part by altering ERalpha-coregulator association., High levels of ERbeta suppress ERalpha expression and response to estradiol in endometrial and endometriotic stromal cells via binding to classic and nonclassic DNA motifs in alternatively used ERalpha promoters., the estrogen receptor 1IVS1-397T allele carriers exhibited an enhanced inflammatory response in vivo and in vitro, We investigated whether ESR1 promoter C driven (ESR1_C) gene expression may shed light on endocrine responsiveness in breast cancer, the expression of SXR in breast cancer cells may alter the ER signaling, which may play crucial role for growth and differentiation of breast cancer cells, ER alpha mRNA is positively correlated with IGF-I mRNA, which implies that estrogen upregulates the gene encoding IGF-I through ER alpha in leiomyoma., In premenopausal women, increased number of ESR1 PvuII and XbaI CG alleles was associated with higher baseline hot flash scores compared with those who had other haplotypes (P = .0026)., Women with a CHEK2 mutation face a fourfold increase in the risk of estrogen receptor-positive breast cancer, miR-18a prevents translation of ERalpha, potentially blocking the protective effects of estrogen and promoting the development of hepatocellular carcinoma in women., the +261G>C polymorphism might influence lipoprotein and lipid levels in premenopausal women, but these effects seem to be modulated by smoking, whereas in men ESR1 polymorphisms were not associated with high lipoprotein levels., No association between genetic variants in ESR1 and ESR2 and the metabolic syndrome was observed among these Caucasian women., A significant correlation between ON promoter hypermethylation and the loss of ESR1 mRNA expression was detected in ovarian carcinoma cells and tisuses., Estrogen recpetor alpha gene may contribute to disease susceptibility and to certain clinical manifestations of systemic sclerosis patients, Results demonstrated that in ER+ breast cancer, the HER2 receptor is commonly activated, but its low prevalence in ER+ tumors does not render it a useful prognostic parameter in tamoxifen-treated patients., GAS interacts with oestrogen receptor-alpha (ERalpha) and participates in both oestrogen receptor-regulated gene transcription and oestrogen-stimulated G1/S cell-cycle transition, Pueraria mirifica has a beneficial effect on lipid metabolism in postmenopausal women, which may result from the activation of gene transcription through selective binding of phytoestrogens to ERalpha and ERbeta., Presence of estrogen and/or progesterone expression in neuroendocrine tumors involving the lung should not exclude a primary pulmonary neoplasm., recombinant TF is capable of down-regulating ERalpha expression in breast cancer cells, resulting in decreases in estrogen-mediated cell proliferation and increased invasiveness, Single nucleotide polymorphism in ESR1 is associated with venous thromboembolism during tamoxifen therapy in breast cancer., These results provide evidence that hypoxia may stimulate yet unknown factor(s), which can further stimulate ERalpha signal transduction pathways., A reduction in ERalpha transcriptional activity measured on a synthetic reporter gene was observed in SRC-2 or SRC-3 but not SRC-1 depleted MCF-7 cells., Importance of ERE-BP as an attenuator of normal ERalpha signaling in vivo and is a novel target for modulation by selective estrogen receptor modulators., There was a down-regulation of ERalpha and aromatase in the stroma of obese prostate cancer patients compared to patients with normal weight., regulates estrogen receptor alpha (ERalpha) by phosphorylating it on serine 167, leading to transcriptional activation of ERalpha., Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor, These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells., Single nucleotide polymorphism rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations., CpG-island methylation of the ER promoter is associated with micrometastases for locoregional recurrence in colorectal cancer, Results provide evidence for a mechanism by which overexpressed progesterone receptor-B is able to actively repress estrogen receptor alpha gene expression., a polymorphism in the ERalpha negative transcriptional element which results in increased transcription in vitro is associated with substantial augmentation of endothelial-dependent vasorelaxation, ERalpha acting as a Trojan horse concentrating 4-OHEN in the nucleus to accelerate the rate of ROS generation and thereby amplify DNA damage. The Trojan horse mechanism may be of general importance beyond estrogen genotoxins., Data demonstrate that a non-aromatizable androgen metabolite, dihydrotestosterone (DHT), stimulated cell proliferation in vitro of both estrogen receptor-alpha (ER-alpha)-positive MCF-7 cells and ER-alpha-negative MDA-MB-231 human breast cancer cells., The disruption of the ERalpha negative transcriptional regulation element by this newly identified polymorphism may influence estrogen-sensitive phenotypes in vivo, The association of certain allelic combinations of ERalpha gene thymine-adenine (TA) polymorphism and aromatase gene TTTA polymorphism on bone mineral density (BMD) in young men, was assessed., Our study does not support a major contribution of the estrogen receptor gene and progesterone receptor gene to the pathogenesis of migraine., Data show that both AF-1 and AF-2 domains of estrogen receptor alpha are required for regulation of MMP-13 promoter activity., Estrogen increases transcription in a rapid but transient manner at early estrogen-repressed genes but that this is followed by recruitment of the corepressor CtBP1, a p300-interacting partner that plays an essential role in the repressive process., up-regulation of Gli1 in breast cancer cells may be one of the mechanisms responsible for developing estrogen independence and this process may be regulated through down-regulation of expression and transactivation of ERalpha, Results are consistent with the hypothesis that variation in ESR1 and ESR2, but not CYP19A1, is associated with an increased arterial stiffness., ER beta, AIB1, and TIF2 appear to be involved in colorectal tumorigenesis and might have prognostic significance., the association of the ESRalpha Pvu II and Xb I polymorphism with severe preeclampsia in a Southwest Chinese population, The TA haplotype defined by PvuII and XbaI was associated with an increased risk of reproductive loss. No association was found for the ERbeta gene., Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305, ERalpha expression was slightly lower in pregnant subjects but the differences were not statistically significant., Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation., ER and PR showed inverse association with HER-2/neu while positive association was seen with lymph node metastases in breast carcinoma patients in Pakistan, Expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis., Estrogen receptor (ER) gene polymorphism was associated with the postoperative result of an rotational acetabular osteotomy, while no association was observed between the acetabular dysplasia with vitamin D receptor (VDR) and ER gene polymorphisms., Presence of A and T alleles (of the XbaI and PvuII polymorphisms, respectively) were associated with higher incidence of carotid restenosis, REVIEW, SRC-1 is a strong independent predictor of reduced disease free survival, whereas the interactions of the p160 proteins with estrogen receptor alpha can predict the response of patients to endocrine treatment., does not provide evidence in favor of ESR1 PvuII and XbaI being associated with preeclampsia but with increased blood pressure levels in normal pregnant women, in a southwest Chinese population, BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells, cross-talk between A2AAR and ERalpha that is involved in ethanol action. This could open new perspectives for the therapy of estrogen-dependent breast cancer., Estrogen/ERalpha exerts a positive feedback role, which promotes permissive histone modifications that are associated with induction of hCYP19 gene transcription., Methylation status of ESR1 in adenomas is not correlated with patient age, but is associated with K-ras mutation, suggesting that methylation of ESR1 in tumors functions differently from that in normal colon mucosa., No significant difference in expression of either ERalpha or ERbeta was found between pure lobular carcinoma in situ (LCIS) of the breast, or LCIS associated with invasive breast cancer., Study did not observe an association between ESR1 PvuII and XbaI gene polymorphisms with CAD in the risk of CAD in an Iranian population., ESR1 variants do not seem to affect myometrial invasion or endometrial cancer survival., ESR1 amplification may be helpful in selecting breast cancer patients who may potentially benefit from endocrine therapy., Genomic responses from the estrogen-responsive elements-dependent signaling pathway are required for estrogen-ERalpha to induce alterations in cellular responses., study suggests that the protective association of enterolactone is reasonably robust across the investigated polymorphisms in the estrogen receptor alpha and beta genes, ER-alpha suppresses ER-alpha 36 promoter activity in an estrogen-independent manner, which can be released by ER-alpha 36 itself, BCAR1 is essential for the rapid estrogen effect on osteoclast differentiation, through estrogen receptor alpha and possibly Traf6., An association between menopausal status - but not BMI - and the intra-tumoral expression of steroid sulfatase and ERalpha., Data show that p53 regulates ER expression through transcriptional control of the ER promoter, accounting for their concordant expression in human breast cancer., selective activation of a subset of the estrogen receptor alpha (ERalpha) cistrome in MCF7 breast cancer cells, The absence of alterations in ER-alpha protein levels could be a characteristic behavior of fibroadenomas, unlike breast cancer., Results place LKB1 in a coactivator role for ERalpha signaling, broadening the scientific scope of this tumor suppressor kinase and laying the groundwork for the use of LKB1 as a target for the development of new therapies against breast cancer., Our results indicate a permanent repression of PAI-1 by ERalpha and suggest a ligand-independent crosstalk between ERalpha and TGF-beta signaling in breast cancer cells., ESR1 haplotypes that included the variant C allele were associated with a reduced risk of obesity, Both prolactin and estradiol resulted in prolonged ERalpha serine-118 phosphorylation and decreased the amount of ERalpha, but by different mechanisms, the ERalpha assay reflects summated activity of compounds in serum, ERalpha is crucial for long-distance regulation of CTSD expression involving a looping mechanism., estradiol affects the expression of MMP-9 and TIMP-1 and syndecan-2, but not of syndecan-4, through ERalpha, these results suggest a novel role for the ERalpha that plays the dual role of ligand-independent activator and ligand-dependent repressor of E-cadherin in breast cancer cells., OTUB1 negatively regulates transcription mediated by ERalpha in transient reporter gene assays and transcription mediated by endogenous ERalpha in Ishikawa endometrial cancer cells, Polymorphisms within ESR1 and ESR2 are associated with age-specific effects on various skeletal traits in healthy fertile women., A functional polymorphism (rs2234693) in estrogen receptor alpha plays a role in the pathophysiology of Japanese methamphetamine- induced psychosis., A cooperative role for ERalpha and c-Myc in estrogen regulation of VEGF and the ability of c-Myc to partially mimic estrogen regulation of angiogenesis., A novel mechanism of estrogen resistance of ovarian cancer by which estrogen-repressed signaling pathway antagonizes estrogen-activated signaling transduction., Estrogen receptor polymorphism, estrogen content and idiopathic scoliosis in human, polymorphism in the alpha estrogen receptor may increase the risk of women developing temporomandibular joint disorder, Data show that microRNA-22 represses estrogen receptor alpha expression most strongly and by directly targeting the ER alpha mRNA 3' untranslated region., The distinct expression of ER and PgR in ductal breast cancers, dependent on evaluated zone of the tumour, confirms its heterogeneous character and exerts an effect on the type of applied treatment., ESR1 may not play a major role in the pathophysiology of schizophrenia and mood disorders., These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity., DYX1C1 interacts with both ERs in the presence of 17beta-estradiol in neurons., This cross-sectional study showed that both equol production and ERalpha polymorphism are closely associated with each other in relation to BMD., Data demonstrate that raloxifene exerted direct protective effects on human osteoblasts in both estrogen receptor alpha/beta dependent and independent manners., PDIp can also serve as an effective modulator of the cellular levels and biological actions of endogenous estrogens in the pancreas where estrogen receptors alpha and beta and PDIp are co-present., Report protective role of estrogen receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells., the induction of Blimp1 represents a novel mechanism whereby the RelB NF-kappaB subunit mediates repression, specifically of ERalpha, thereby promoting a more migratory phenotype in breast cancer cells, Results indicate that Wip1 up-regulation is important in the pathogenesis of p53(+) and ER(+) breast cancer through the inactivation of p53 by dephosphorylation and the amplification of subsequent estrogenic effects through the E(2)-ERalpha-Wip1 pathway., Expression of ER, progesterone receptor, and HER2 proteins and the Ki67 index appear to distinguish luminal A from luminal B breast cancer subtypes, data suggest that the ESR1 (rs2234693 and rs9340799) and the ESR2 (rs1255998 and rs944050) polymorphisms may be associated with an increased risk of developing endometrial cancer., estrogen receptor splice variant and ErbB4 may have roles in gene susceptibility pathways in schizophrenia, ESR1 PvuII and XbaI gene polymorphisms did not seem to have an effect on lipoprotein metabolism or on inflammatory variables such as CRP, Transcriptional profiling demonstrated that Bcl3 activates genes involved in diverse pathways including a subset involved in cellular energy metabolism known to be regulated by PGC-1alpha, ERRalpha, and a second nuclear receptor, PPARalpha., Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells., AF2 domain contributes to dioxin-induced recruitment of ERalpha to AHR target genes, but that both the AF1 and AF2 domains are required for ERalpha-dependent increases in AHR activity., The three markers (ER, Vim and CEA) and their respective panel expressions showed statistically significant (p < 0.05) frequency differences between endocervical adenocarcinomas and endometrial adenocarcinomas tumors., ERalpha is rarely expressed while ERbeta and PELP1/MNAR are involved in colorectal tumorigenesis., The K303R ERalpha mutation might be a new predictive marker of response to aromatase inhibitors in mutation-positive breast tumors., Single nucleotide polymorphisms in ESR1, CETP and LPL had significant effects on baseline plasma levels of TG-rich and HDL subpopulations., Severe obesity in Han Chinese was associated with 3 novel common SNPs for ESR1 and PPARgamma. These 2 genes collectively result in a >5-fold risk of severe obesity., Studies discovered a novel molecular network between p53, KLF4 and ERalpha., Methylated state of this set of genes may be more specific to the late rather than the early stage of NSCLC., ER alpha expression may influence vascular endothelial function in women by affecting protein levels and activation of eNOS., The results presented here identify SMYD3 as a new coactivator for estrogen receptor-mediated transcription, providing a possible link between SMYD3 overexpression and breast cancer., The SNP T594T (ESR1), but not the D6S440 (ESR1)and D17S189 (THRA)is associated with thyroid cancer risk., The different subtypes of malignant ovarian germ cell tumours all express ERalpha, ERbeta, and SNURF., M543V shows more ERalpha transcription with antiestrogens vs E2. Relative hydrophobicity of AA side chains on the inner face of Helix 12 is needed for active, agonist conformation with bound E2. The N-terminal AF-1 plays a role in AP-1/ERalpha cross-talk., This result suggested that ERalpha plays a significant role in leukaemogenesis, 17beta-estradiol (E2) can rapidly enhance aromatase enzymatic activity through an increase of aromatase protein phosphorylation in breast cancer cell lines., Nuclear localization of P-ser118-ER alpha provides one explanation for sex-dependent differences in E(2)-genomic responses in lung adenocarcinoma cell lines., Study found that RARalpha/RARgamma exhibit extensive colocalization of their genomic binding regions with ERalpha in the vicinity of genes that are antagonistically regulated by estrogen and RA., results allowed the identification of mutation-resistant positions in estrogen receptors, demonstrate not only that dioxin induces the recruitment of ERalpha to AHR target genes but that AHR is recruited to estrogen-responsive regions in a gene-manner, suggesting that AHR utilizes these mechanisms to modulate estrogen-dependent signaling, The analyses indicate that both gene activation and repression by estrogen-bound ERalpha rely on an intact DNA-binding domain in vivo., ER, PR and Her2 have roles in progression of breast cancer, Association of ER-alpha gene polymorphism with metabolic phenotypes in Chinese Hans., Nuclear factor-kappaB regulates estrogen receptor-alpha transcription in the human heart, ESR1 gene polymorphisms may be associated with the AAO in AD. The present results provided information for possible associations between certain polymorphisms of ESR1 gene and the risk of AD., NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ERalpha and the H-ras/p-c-Raf and JNK2/AP-1/MMP1 signaling pathways., Studies indicate that estrogen receptor-positive tumors with increased proliferation, evaluated by Ki-67, may be selectively responsive to aromatase inhibitor therapy., Data demonstrate in caveolae of human cortex and hippocampus the presence of pl-VDAC and ERalpha, in a complex with scaffolding caveolin-1 which likely provides ERalpha stability at the plasma membrane., Data show that DACH1 expression, which is lost in poor prognosis human breast cancer, functions as an endogenous inhibitor of ERalpha function., Confirm the lack of association between the ESR1 rs223469 and coronary heart disease., These data support a model of repression wherein actions of ERalpha and Sin3A at the proximal promoter can overcome activating signals at distal or proximal sites and ultimately decrease gene expression., Studied the association of EGFR and ESR1 SNPs with breast cancer risk and prognosis in Tunisian patients. The ESR1 2014G allele showed significant association with breast cancer risk (P = .025)., selected genetic polymorphisms of ESR1 and ESR2, overall, were not associated with prostate cancer risk. However, a variation in risk by BMI and phytoestrogen intake was implicated, The positive expression rate of ER decreased significantly from DCIS to invasive ductal breast carcinoma. A significant positive correlation was observed between ER and PgR receptor expression in DCIS and IDC., ESR1 PvuII polymorphism is not associated with angiographically significant CAD. ESR1 BtgI polymorphism is strongly associated with the presence of normal coronary angiograms in women, which suggests protective effect., In univariate analyses, Tau- and ER-positive status were both associated with better DFS and OS (P < .0001) whereas greater tumor size, high grade, lymph node- and HER2-positive status were each associated with worse DFS and OS., ESR1 PvuII polymorphism is a significant risk factor for migraine particularly in women and migraine with aura patients, but ESR 325 C-->G polymorphism is not associated with migraine susceptibility, Patterns and extent of ER and CK5 staining, when used together, are valuable adjunct stains to differentiate usual duct hyperplasia from atypical proliferations within papillary lesions on breast, Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer., significant association between magnesium and ESR1 polymorphisms, Both antiestrogen sensitive and antiestrogen resistant breast cancer cells showed the ability to switch between ERalpha and ErbB signaling depending on the applied treatment, thus supporting combined therapy targeting both receptor systems., identify the subset of microRNAs (miRNAs) modulated by ERalpha, which include upregulation of miRNAs derived from the processing of the paralogous primary transcripts (pri-) mir-17-92 and mir-106a-363, Estrogen receptor alpha and beta expression distinguishes a subset of NSCLC that has defined clinicopathologic and genetic features. In lung adenocarcinoma, estrogen receptor alpha expression correlates with EGFR mutations., Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1., SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway., A crucial role for p72 in ERalpha co-activation and oestrogen-dependent cell growth., Studies show that the intrinsic molecular signature of five markers, ER, PR, HER-2, CK 5/6, and EGFR, demonstrated specificity of 100% and sensitivity of 75%, compared with classification by gene expression profiling., certain olfactory sensory neurons naturally co-express olfactory receptors and ESR1, TLR9 signal pathway, by activating NF-kappaB, negatively regulates ERalpha-mediated transactivation of breast cancer, lower expression in menopausal women, ERalpha C allele confers approximately 2-fold increased risk of causing both endometriosis and fibroids, indicating that it can be considered risk marker in Asian Indian Women., we described a tumor suppression function of miR-145 in breast cancer cell lines, and we linked miR-145 to TP53 and ER-alpha, ER-alpha mRNA expression is associated with good patient outcome for death from breast cancer., Polymorphisms in ESR1_rs910416 and AR_(CAG)n are associated with postmenopausal breast cancer risk associated with menopausal hormone therapy., The conformational dynamics revealed by the use of hydrogen-deuterium exchange mass spectrometry for ERbeta ligand binding domain (LBD) together with those for ERalpha LBD shed light on ER ligand interactions and offer new structural insights., G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells, Data show that variant isoforms of estrogen receptor related beta protein have differential effects on ER alpha-dependent gene expression, and possibly on endometrial cell function., ERbeta1 and two ERbeta variants (ERbeta2, ERbeta5) were expressed in endometrial cancers and the proteins were immunolocalised to the nuclei of cells in both epithelial and stromal compartments., These results suggest that potentially functional ESR1 polymorphisms may play a low penetrance role in breast cancer susceptibility, results suggest that the PvuII polymorphism of ER-alpha gene as well as XbaI polymorphism may not be linked with appearance and development of endometrial cancer., The aim of the current study was to assess the expression levels of c-Src and phosphorylated Src kinase in human breast cancers and to establish if these are linked to oestrogen receptor, progesterone receptor, and HER2 status or patient survival., describes in detail the BRET(2) assay as it is used to examine the physical interaction between the nuclear receptor ERalpha and the transcriptional coactivator SRC-1, Data show that valproic acid, inducing estroegn receptor alpha and FoxA1, confers to MDA-MB 231 cells an estrogen-sensitive "phenotype", restoring their sensitivity to antiestrogen therapy., Testosterone induces ERK and Akt phosphorylation via the membrane-initiated signaling pathways mediated by ER-alpha36, suggesting a possible involvement of ER-alpha 36 in testosterone carcinogenesis., PvuII (rs2234693) and XbaI (rs9340799) restriction fragment polymorphisms of the oestrogen receptor alpha gene probably do not play a role in the pathomechanism of myasthenia gravis in Caucasian women, ERalpha and Foxl2 interact and that Foxl2 selectively suppresses ERalpha-mediated transcription of AP1-regulated genes., Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptors ERalpha and PR signaling in leiomyoma cells, ERalpha expression positively correlated with PR expression in endometrial cancer., A possible role of ESR1 variants on HA is suggested., estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway, The presence of ERalpha in the majority of tumors diagnosed during pregnancy indicates that the poorer outcome of these cases could be related to the estrogen-mediated growth stimulus., abnormal expression of hormone receptor contribute to endometrial polyps formation, Data support a model in which Notch-1 can activate the transcription of ERalpha-target genes via IKKalpha-dependent cooperative chromatin recruitment of Notch-CSL-MAML1 and ERalpha, which promotes the recruitment of p300., an important role for the K303R ERalpha mutation in hormonal regulation of tumor growth and estrogen-regulated promoter dynamics in human breast cancer, G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation., Interactions of MinK and e-NOS gene polymorphisms appear to be inconsistent predictors of atrial fibrillation propensity, but long alleles of ESR1 promoter TA repeat may be a promising marker., Polymorphisms in the Estrogen Receptor Alpha gene are associated with premature ovarian failure., Polymorphisms at the ESR1 gene are associated with infertility in this Turkish infertile women population., detected ERalpha binding to STAT3 and JAK2 (Janus kinase 2), resulting in enhanced JAK2 activity upstream of STAT3 in response to leptin that might lead to an increased ERalpha-dependent cell viability, No relationship of Akt phosphorylation with HER2, ER-alpha or ER-beta expression in breast cancer was found, Results show no significant association between hand osteoarthritis and the investigated polymorphisms of ESR1 or ESR2 despite published reports of association and a priori hypotheses implicating their potential roles., Notably the ratio of ERalpha-positive reactive astrocytes to total reactive astrocytes increased and significantly correlated with the severity of cognitive impairment following HIV infection., estrogen receptor (ER), progesterone receptor (PR), and HER2 have roles in breast cancer, Data suggest post-translational modification (i.e., acetylation versus ubiquitination) of ESR1 is regulated by BRCA1 (breast cancer gene 1 product). Thus, ESR1 activity is regulated by BRCA1., comprehensive mapping of the chromatin interaction network bound by oestrogen receptor alpha (ER-alpha) in the human genome, Studies reveal dynamic interplay between ESR1 and ESR2 in their selection of chromatin binding sites and reveal expansion of binding sites exclusively for ESR1 or for ESR2 when both ESR are present., no relationship between ERalpha polymorphism and the stage of osteoporosis related to the spinal body mass density value, Role of genetic polymorphism of estrogen receptor-alpha gene and risk of prostate cancer in north Indian population, Some common SNPs in the ESR1 could be important in modulating carotid atherosclerosis and thereby CVD susceptibility in Taiwanese women., only a subpopulation of ER alpha was available to form complexes with the interacting domains of cofactors in the cell, Our results suggest that ESR1 might have a potential role in hyperlipidemia risk, independent of age, estradiol level, body mass index and lifestyle in Chinese Han postmenopausal women., These findings provide further evidence of the importance of mediators of the growth factor signaling in ER regulation, introducing the Akt2/FoxO3a axis as a pursuable target in therapy for ER-positive breast cancer., Clomiphene citrate may inhibit E2-induced endometrial epithelial cell proliferation and ERE transactivation by inhibiting the recruitment of SRC-1 to ER alpha., No association was found between other ESR1 polymorphisms and HDL levels. According to the results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT., ERalpha expression and Bax/Bcl-2 ratio were similar in fresh and cryopreserved ovarian tissue, Data show that Cyclin D1, a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon in a phospho-ERalpha-Ser-167-dependent manner., Promoter hypermethylation was observed in PRB 67%, ERalpha 64%, RASSF1A 63%, p16INK4A 51%, RARbeta2 22%, GSTP1 25% and BRCA1 27% of the breast cancers, respectively., Our findings suggest that the combined genetic polymorphisms of CDK7 and ESR1P325P are associated with breast cancer in Korean women., ERalpha mRNA expression was increased in left ventricular specimens from coronary disease and dilated cardiomyoapthy patients vs controls. This might reflect a compensatory mechanism to counteract the decline in ventricular function., Results reveal a novel link between proteasome activity and expression of ERalpha in breast cancer and uncover distinct roles of the chymotrypsin-like activity of the proteasome in the regulation of the ERalpha pathway., Results from MCF-7 cells suggest that ERalpha interacts with 8 widely spaced regions of progesterone receptor (PR) gene (from 311 kb upstream to 4 kb downstream of the PR-B transcription start site)., rs2077647 in ESR-alpha is associated with risk for prostate cancer., The evaluated single nucleotide polymorphism in estrogen receptor 1 did not seem to influence bone marrow density in tamoxifen-treated subjects with breast cancer., Aberrations in the interaction between the ER and NFkappaB signalling pathways may have a negative impact on implantation contributing to pathologies such as early pregnancy loss and infertility, the cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on ERalpha-mediated transcription, ER alpha polymorphisms were found to be associated with sperm motility and concentration, supporting the significance of this gene in spermatogenesis and semen quality, ESR1 gene is quantitative trait loci (QTL) underlying fat mass variation in young Chinese men., Toker cells and mammary Paget cells differ substantially in their expression of ER, c-erbB-2 and Ki-67., Morphology and ERalpha protein and gene expression in two breast cancer cell lines after three different fixatives., he role of oestrogen receptor {alpha} in human thyroid cancer., K18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm., The growth of ER-negative SKBr3 breast cancer cells was inhibited by ERalpha expression, These results indicate that the GG genotype of the G2014A polymorphism is associated with the risk of failure in the mifepristone-induced abortion., 17beta-estradiol enhances alpha(5) integrin subunit gene expression through ERalpha-Sp1 interaction and reduces cell motility and invasion of ERalpha-positive breast cancer cells., a single nucleotide polymorphism downstream of ESR1, a gene called spectrin repeat containing, nuclear envelope 1, was associated with invasive ovarian cancer risk, ESR1 PvuII and XbaI haplotype is associated with BP variation and the reduction in cardiac autonomic nervous activity in young Japanese males, which may be precursors of future pathological episodes of cardiovascular diseases, BRCA1 and BARD1 are required for estrogen receptor alpha ubiquitination and degradation, and repression of either one leads to ERalpha accumulation, suggesting a feedback loop between BRCA1-BARD1 and estrogen receptor alpha, The age at menarche was not related to ERalpha gene polymorphisms height is, The 4th passage cell cultures from Fallopian tube muscularis exhibiting interstitial Cajal-like cells morphology showed the presence of ER-alpha and/or PR-A by immunofluorescence., ERs recruit SMRT through an unusual mode of interaction involving multiple contact surfaces., The human IP gene is directly regulated by estrogen that largely occurs through an ERalpha-dependent transcriptional mechanism., Reporter gene assays revealed that ERalpha and ERbeta increased CYP2B6-regulated gene expression through a functional ERE located at -1669 to -1657 in the upstream regulatory region of CYP2B6., Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity., ERalpha could in some cases actually lead to reactivation of the mutants toward at least some response elements., MYCN amplification may disrupt estrogen signaling sensitivity in primitive sympathetic cells through deregulation of ESR1., Retinoic acid receptor-alpha is an essential component of the estrogen receptor-alpha (ER)- complex, potentially by maintaining ER-cofactor interactions, and different nuclear receptors can cooperate for transcriptional activity in breast cancer cells, GPR30 antagonizes growth of ERalpha-positive breast cancer and may represent a new target to combat this disease., The ERalpha pathway promotes cell proliferation by activating the Hh pathway in a ligand-dependent manner through Shh induction of ERalpha-positive gastric cancer., ESR1 gene including PvuII and XbaI polymorphisms may modify the risk of idiopathic premature ovarian failure (POF) but not idiopathic early menopause (EM) risk., Contributions of estrogen receptor-alpha and estrogen receptor-ss to the regulation of behavior., Data show there was a strong inverse correlation between slug and ERalpha and E-cadherin immunoreactivity in breast cancer cases., Findings suggest that RBCK1 regulates cell cycle progression and proliferation of ERalpha-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1., Down-regulation of ER-alpha36 is associated with carcinogenesis and progression of breast cancer., Study shows a simultaneous involvement of epigenetic regulation for both CXCL12 and ESR1 genes in Brazilian women. Methylation status of both genes was significantly correlated with histologically advanced disease, the presence of metastases and death., The association of some polymorphisms in the region of exon 4/intron 4 of ESR1 and hip fractures was significant in females., Data show that estradiol, acting through estrogen receptor alpha, up-regulates COX-1 and prostacyclin synthase expression, thus directing prostanoid balance toward increased prostacyclin production., analysis of transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha, The ESR1 gene is associated with low bone mass and low estradiol levels in all our study subjects. It is likely that the allele exerts its influence on the bone in early adulthood leading to an increased risk of osteoporosis later in life., characterized geneticc association between ER-alpha SNP and knee osteoarthritis in the Thai, Data indicate that estradiol may be a key factor controlling the turnover of adult pancreatic beta cells by regulating the proliferation and differentiation of adult human islet-derived precursor cells through oestrogen receptor alpha., I3C is a novel anticancer agent in human cancers that coexpress ERalpha, GATA3, and AhR, a combination found in a large percentage of breast cancers but not in other critical ERalpha target tissues essential to patient health, Both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors., Our study suggests that the minor allele -397C of the ESR1 gene confers risk of coronary heart disease among Finnish men, both in homozygous state and as part of a haplotype with the -351A allele., The data of this study demonstrated affective state-independent personality traits that distinguish patients with Premenstrual Dysphoric Disorder from controls and support ESR-1 polymorphic variants in the regulation of non-reproductive behaviors., variants in estrogen receptor genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men., ER, PgR and E-cadherin are expressed in canine mammary gland columnar cell lesions; cytokeratin 34betaE-12, HER-2 and P53 are not expressed, The effect of lapatinib on ERalpha signaling varied markedly depending on the nature of the HER2/ERalpha cross-talk, Our results suggest that patients with tumors expressing Pak1 and pERalpha(ser305) in combination are a group in which tamoxifen treatment is insufficient, microRNA-22 is an estrogen receptor alpha suppressor that is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples, Results demonstrated that previously reported activities of GPR30 in response to estrogen were through its ability to induce ER-alpha36 expression., Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation., The PP+Pp genotype of the ESR1 gene was more frequent than pp genotypes in subjects with dysmenorrhea than in subjects without dysmenorrhea., Report an estradiol-inducible adenovirus-mediated gene transfer system for nuclear delivery of a p16INK4A-estrogen receptor carboxy terminal fusion protein., Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex., Genetic variation in ESR1 is associated with serum estradiol levels and body fat content regulation in men., Estrogen receptor alpha from MCF-7 breast carcinoma cell lysates immobilized inside a hollow-core photonic crystal fiber was detected using anti-ER primary antibody with Alexa Fluor 488 or 555 labeled Goat anti-rabbit IgG as the secondary antibody., PKA-induced phosphorylation of ERalpha at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer., Single nucleotide polymorphsims in ESR1 do not associate with hypospadias in a Dutch study., Collectively, our findings suggest that tamoxifen resistance is a result of increased ERalpha/Sp-1 interaction, which enhances the expression of E2F1 to promote tamoxifen resistance., Upregulated ESR1 is associated with breast cancer., Data show that, upon estrogen stimulation, DNA-PK forms a complex with ERalpha in a breast cancer cell line (MELN)., subcellular localization of activated AKT is dependent on TCL1B expression in estrogen receptor- and progesterone receptor-expressing breast cancer, CpG islands aberrant hypermethylation of estrogen receptor is associated with leukemia., MBD2 and ERalpha drive opposite effects on pS2 expression, which are associated with specific steady state levels of histone H3 acetylation and methylation marks, p21Waf1/Cip1 gene expression is induced in estrogen responsive MCF-7 breast cancer cells and Sp1 is involved in the recruitment of ERa to the p21Waf1/Cip1 promoter., Data suggest that estrogen receptor (ER)alpha46 appears to enhance endocrine responses by inhibiting selected ERalpha66 responses., Results support a role of estrogen and aromatase in pathogenesis of systemic lupus erythematosus and suggest that genetic variants in the estrogen receptor alpha and beta genes might influence susceptibility., Results describe the expression of estrogen receptor alpha, estrogen receptor beta, progesterone receptor and cKIT in a number of desmoids tumors and their role in determining treatment options., The HindIII polymorphism of the osteocalcin gene, but not the PvuII polymorphism of the estrogen receptor alpha gene or their potential interaction, was associated with body mass index in premenopausal Chinese women., ER+/PR- tumors more frequently showed HER2 (human epidermal growth factor receptor) overexpression and represent a distinct subset in familial breast cancer patients., The actin network plays a role in nuclear ERalpha actions in breast cancer cells., The binding of steroid receptor coactivator-1 (SRC-1) to the AF-1 domain of ERalpha is essential but not sufficient to facilitate synergy between the AF-1 and AF-2 domains, which is required for a full agonistic response to estradiol., The positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer., The interaction of estrogen receptor alpha polymorphisms with calcium supplementation on bone density in Chinese girls at puberty is reported., We investigated methylation patterns in the promoter regions of ABCB1, ATM, BRCA1, CDH3, CDKN2A, CXCR4, ESR1, FBXW7, FOXC1, GSTP1, IGF2, HMLH1, PPP2R2B, and PTEN75 in well-described pre-treatment samples from locally advanced breast cancer, Positive estrogen receptor alpha is associated with gastric cancer., Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs, Hsp90 is essential for the proper dimerization of ERalpha/alpha and ERalpha/beta, it is not required for the proper dimerization of ERbeta/beta., The results suggest that the PvuII and XbaI RFLPs of the ER1 gene may be genetic factors that affect QUS at the calcaneus, phosphorylation of CARM1 by PKA at a single serine is necessary and sufficient for direct binding to the unliganded hormone-binding domain of ERalpha, and the interaction is necessary for cAMP activation of ERalpha, E2-mediated thyroid cancer cell proliferation involves ERalpha and ERbeta transcriptional and non-genomic signaling events, Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells, This study suggested that strongly in favor of an association between ESR1 polymorphisms and anorexia nervosa., Study show that miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10, thereby enhancing expression of ERalpha., Genotyped six SNPs in 163 Caucasian cancer patients and 114 healthy controls using hybridization probes; performed Armitage;s association trend-test to evaluate the risk. Linkage disequilibrium (LD) was assessed for each pair of markers., Data suggest that the negative regulatory loop involving miR-221-222 and ERalpha may confer proliferative advantage and migratory activity to breast cancer cells and promote the transition from ER-positive to ER-negative tumors., This work indicates that the sequence of the tri-nucleotide spacer is non-random at receptor-bound genomic loci, influences estrogen receptor alpha-DNA-binding affinity, and modulates transactivation potential of the receptor-ligand-DNA complex., down-regulation of caveolin-1 protein expression leads to deregulate estrogen receptor alpha (ERalpha) signaling and consequently early transformation in mammary epithelia, Common genetic variations of the aromatase and ER genes are associated with the risk of severe OA of the large joints of the lower limb in a sex-specific manner., Our data show that alternative splicing of ERalpha mRNA is diminished in the AD brain and more prominently in AD female cases., role of polymorphism in pathological process (Review), Single nucleotide polymorphisms in ESR1 is associated with breast cancer., This paper briefly reviews the assessment of ERalpha, PgR, and HER2 in breast cancer, emphasizing recent progress and persistent controversies., These results identify a conserved and novel function for Hsp27 with potential as a target for interrupting signaling from estrogen receptor alpha and androgen receptors to tumor biology in hormone-responsive cancers., These results suggest that PELP1 is a reader of H3 methylation marks and has a crucial role in modulating the histone code at the ERalpha target genes., ER-a overall expression was associated strongly to ESR1 gene copies only in breast carcinoma and not in colon or hepatocellular carcinomas, hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway., The level of ESR1 expression, determined by real-time PCR, directly correlated with the optical redox ratio in breast cancer., ESR1 promoter appeared to be unmethylated in patients with metastatic breast cancer., ERalpha may play a role in endometrial cancer and the 975C > G-ERalpha polymorphism may be considered an independent, early diagnostic marker in this disease., that methylation of ESR-1 promoter is higher in ulcerative colitis (UC)patients compared with age and sex matched controls, ER-alpha36 expression may be used as a predictive marker for lymph node metastasis of gastric cancer., Estrogens stimulate dynamic endothelial protein S-nitrosylation via mechanisms linked to specific ERs possibly on the plasma membrane and endogenous nitric oxide., results indicate that both ERalpha and ERbeta were involved in the process of osteogenic differentiation of periodontal ligament stem cells, The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population., E2 stimulation induced recruitment of ERalpha and loss of RNAPII at the proximal promoter of Kiss1., Our data showed intracellular and surface membrane expression of ERalpha in peripheral blood lymphocytes., confirmed a role for Runx1 in mediating ER alpha genomic recruitment and regulation of tethering genes, The HER4 intracellular domain is a physiologically important ERalpha coactivator and cooperates with ERalpha to potentiate PgR expression in the normal and malignant breast., This pilot study supports our hypothesis that ESR1 amplification is associated with a poorer outcome following adjuvant treatment with tamoxifen in ER positive early breast cancer., Data show that the concordance rates of histological type, estrogen receptor and progesterone receptor status, and HER2 were 84.4%, 81.3%, 92.9%, and 89.3%, respectively between CNB and surgical specimens., There were no statistically significant differences in the overall associations between the ER-alpha exon I CT genotypes and uterine leiomyoma (P = 0.47)., Our findings provide support for diverse roles of ESR1 polymorphism in determining susceptibility in different stages of breast cancer., Higher levels of ER-alpha36 expression are required for preserving bone mass in postmenopausal and menopausal women., Results indicate that loss of ESR1 has a major role in mediating cervical cancer invasion and progression., The objective of this study was to evaluate the presence of estrogen receptors (ER) alpha and beta in various thyroid lesions and to assess the practicality of this test., Genetic variants in ESR1, ESR2, and HSD17B1 genes could modify susceptibility to endometriosis and might influence the fertility status in endometriosis patients., phytoestrogen extracts isolated from flax have effects on estradiol production and ER/PR expression in MCF7 breast cancer cells, the binding of the DNA-binding domain of ERalpha to a 21-mer dsDNA oligo containing the estrogen response element motif was analysed., Results indicate that ER-alpha36 is a new member of the ER-alpha family that mediates membrane-initiated estrogen signaling and that synuclein gamma can replace the function of heat shock protein 90., The analysis of both estrogen receptors might be used as a marker to identify high-risk patients only in a subset of patients with endometrioid adenocarcinoma., The -351A/G ESR1 polymorphism might be associated with myocardial infarction, but not with extreme longevity., The study shows association between the XbaI and PvuII polymorphisms of the ESR1 gene and, RsaI and Alul polymorphisms of the ESR2 gene and male fertility status., Our data demonstrate that dual targeting of EphA2 and ER is a promising approach for delaying resistance to Tamoxifen., Results suggest that Hakai is a novel corepressor of ERalpha and may play a negative role in the development and progression of breast cancers., Our data suggest that XbaI and possibly PvuII polymorphisms of the ESR1 gene influence the impact of raloxifene treatment on endothelial function., Polymorphisms of ESR-1 were not associated with any subtype of urinary incontinence., PRDX1 was associated with the cyclooxygenase (COX)-2 upstream promoter region at sites occupied by NF-kappaB in ER- but not in ER+ breast cancer cells., Although certain symptoms of temporomandibular disorder (TMD) were found to have a relatively higher prevalence of one form or another of the estrogen receptor allele, no haplotype was confirmed to be a significant marker of TMD risk., SNPs associated with breast cancer differ for Asian, European, and African ancestry groups, Report a decrease in ERalpha expression in breast cancer patients responding to preoperative systemic chemotherapy., These results elucidate that ER regulates an evolutionarily conserved apoptosis pathway, vitamin D receptor and estrogen receptor 1 gene polymorphisms have an effect on bone mineral density in postmenopausal women, postmenopausal women with a high frequency of PvuII polymorphism pp genotype are more predisposed to ischemic stroke, evaluated and summarized results of studies involving rs2234693 and rs9340799 and clustered risk factors for development of cardiovascular disease(CVD); studies provide some support for relationship between polymorphisms in ESR1 and risk factors for CVD, New insights into the possible effect of some lifestyle-related factors on the aberrant methylation drift of ERalpha and RARbeta2 genes in breast cancer., miR-30b is selectively downregulated in prefrontal cortex of female but not male subjects with schizophrenia and this is associated with sequence variations in the Esr1 estrogen receptor, The mRNAs of SSTR subtypes 1, 2, 3, and 5, dopamine receptor and ERalpha were measured by in 59 non-functioning adenomas and 50 functioning adenomas., epistasis between ESR1 and CYP19A1 may be involved in the regulation of folliculogenesis, multicellular spheroids of MCF-7 breast cancer cells presented a paradoxical regulation of estrogen receptor alpha, with a decrease in protein expression and a marked increase in mRNA steady-state levels., ERalpha stable transfection inhibits proliferation and migration capacities of MDA-MB-231 cells and decreases expression of COX-2 and VEGF-C., ESR1 PP (odds ratio = 2.2) and CYP19 genotypes carrying the T allele (odds ratio = 1.9) were significantly associated with longevity., ESR1 genotype was not associated with any changes in serum lipid concentrations in patients receiving treatment with tamoxifen., Estrogen receptor/progesterone receptor status were independent predictive factors of pathologic complete response to neoadjuvant docetaxel plus epirubicin combination chemotherapy in locally advanced breast cancer., Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder., Study provides the first evidence of an association between polymorphisms in the ESR gene with DF in high-fluoride-exposed populations., Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation., Estrogen receptor/progesterone receptor status (and nm23-H1) are independent predictive factors of pathologic complete response to neoadjuvant docetaxel plus epirubicin combination chemotherapy in patients with locally advanced breast cancer., Studies indicate that breast carcinomas Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features, Recruitment of FAK and N-WASP is necessary for cell migration and invasion induced by 17beta-estradiol in breast cancer cells., The data indicate that the studied SNPs on ERS1 gene do not influence the menstrual cycle timing and parity but there is a strong relationship between the xx ERS1 SNP genotype and the incidence of miscarriage in the post-menopausal population analyzed., we were unable to demonstrate any association between ESR1 promoter polymorphism and nonsyndromic cryptorchidism in Italian and Spanish study populations, The EGF-induced ERalpha cistrome specifically regulates genes found overexpressed in ERBB2-positive human breast cancers, Data show that DFS was statistically different between the two groups, estrogen receptor, progesterone receptor, and HER-2 may have a role in progression in breast cancer despite response to doxorubicin/cyclophosphamide therapy, Estrogen receptor alpha36 mediates nongenomic estrogen signaling through the epidermal growth factor receptor/Src/extracellular signal-regulated kinase signaling pathway in estrogen receptor-negative breast cancer cells., Raloxifene effects on prostate cancer cell growth control in vitro are cell-specific, depending on ERbeta or ERbeta/ERalpha relative expression levels., Estrogen receptor-alpha plays a central role in mediating alpha9-nAChR gene up-regulation in response to either nicotine or estradiol stimulation., estrogen-occupied ERalpha activates and interacts with extracellular ERK2, a downstream effector in the MAPK pathway, resulting in ERK2 and ERalpha colocalization at chromatin binding sites across the genome of breast cancer cells, the antimetastatic activity of raloxifene in mammary cancer may be related to expression of cytoplasmic ERalpha, additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine., identification of new splicing variants of estrogen receptor alpha in human endometrium, Data show an association between ESR1 polymorphism and juvenile SLE, and an association between ESR2 polymorphism and adult SLE., ERalpha correlated positively with progesterone receptor expression (normal controls), and maternal BMI at delivery (fetal growth restriction)., ESR1 amplification as detected by multiplex ligation-dependent probe amplification is rare in breast cancer., Data show that inhibiting miR-375 in ERalpha-positive MCF-7 cells resulted in reduced ERalpha activation and cell proliferation., The loss of periodic expression of ERalpha in the endometrial-myometria interface of adenomyosis may be associated with an abnormal regulation of estrogen in adenomyosis., ER, PR and Her-2 are independent prognostic factors for locoregional recurrence and survival in node-positive breast cancer patients treated by mastectomy., HBO1 was an important downstream molecule of ERalpha, proteasome-dependent degradation of ERalpha is enhanced by p-fluoro-4-(1,2,3,6,-tetrahydro-1,3-dimethyl-2-oxo-6-thionpurin-8-ylthio) (TPSF) in breast cancer cells, in ER negative basal and HER2+ breast cancer, gene expression modules reflecting T-cell helper-1 (Th1) and T-cell helper-2 (Th2) mediated immune responses play antagonistic roles as major risk factors for distant metastasis, ERa gene polymorphism could affect the shift of T lymphocyte subsets and the expression of the related cytokines in primary cholestasis cirrhosis patients., COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer, Ressults suggest a possible involvement of ER-alpha36 in E2-dependent growth-promoting effects in endometrial cancer cells., We have demonstrated that ERalpha expression in vestibular schwannoma is equivalent to that of the great auricular nerve. However, the phosphorylated form of the receptor is up-regulated compared with the great auricular nerve., High expression of ERalpha and the estrogen-induced gene EIG121 predicts shorter overall survival in patients with high-grade serous ovarian carcinoma., Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-alpha., MST and hSAV act as novel co-regulators of ERalpha and may play an important role in breast cancer pathogenesis, The estrogen receptor polymorphisms did not modify the increased risks of coronary heart disease, stroke, or venous thromboembolism due to hormone therapy., CDB-4124 has an effect on progesterone and estrogen receptors, and may suppress the development of precancerous lesions, ERalpha enhances endothelial cell motility through the dynamic control of actin arrangement and the formation of focal adhesion complexes, This small pilot study demonstrates the ubiquitous nature of ER splice variants in these tissue sites and suggests that ERalphaDelta5 may be involved in progression of prostate adenocarcinoma, The authors identi fi ed one novel non-coding exon and several splicing events that generate exon 1-containing and exon 1- lacking human ER-alpha F isoforms in a wide variety of human tissues., An ER post-translational modification code may exist, reflecting the balance of ligand-mediated & cross-talk signal transduction pathways where integration of diverse signals occurs regulating breast cancer cell growth & survival. Review., analysis of ER in breast cancer and false negative reactions by immunohistochemistry, Studies indicate that aUPD is a common and non-random molecular feature of breast cancer that is most prominent in HER2/ER/PR triple negative cases., ER-alpha gene polymorphisms may be a susceptible indicator for BMD variation of lumbar spine L2-L4 and Ward in Chinese pre- and post-menopausal women patients with chronic periodontitis., Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth., data provide new insights on the protein-protein interaction networks controlled by ER-alpha and -beta that mediate their ability to transduce estrogen signaling in breast cancer cells, RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2., Tamoxifen and raloxifene reduce progesterone and estrogen receptor alpha expression significantly and to a similar extent in the non-neoplastic breast tissue of women of reproductive age, ERalpha, ERbeta and GPER1/GPR30 are involved in preventing beta-cell apoptosis, impeding the loss of critical beta-cell mass., Nylestriol and levonorgestrel can both up-regulate the mRNA expression of ER subtypes in MG-63 cells., royal jelly's components, although structurally entirely different from E(2), mediate estrogen signaling by modulating the recruitment of ERalpha, ERbeta and co-activators to target genes, Low Estrogen receptor alpha expression is associated with ovarian cancer., ER-alpha and ER-beta mRNA were expressed in human tongue squamous cancer cell, and the expression of ER-beta was weaker than that of ER-alpha., Estrogen receptor expression in atypical hyperplasia does not seem to be associated with breast cancer, PIK3CA mutation and the Wnt pathway have roles in ERalpha-positive breast cancer, The expressions of ERalpha and p-ERalpha were negatively correlated with the expression of IL-6 in hepatitis B-related hepatocellular carcinoma., ESR1 as a candidate regulator of proopiomelanocortin in hypothalamus, results suggest that calcium mediates the cross-talk between ERalpha-activating signaling pathways, genetic variations within DNA promoter elements may fine-tune the physiological action of ERalpha and other nuclear receptors, Our results suggest that the less frequent CC genotype in obese premenopausal women is related to narrower femoral neck and higher cortical density at the tibial shaft compared to the TC and TT genotypes., RAC3 is a novel ERalpha co-activator that promotes cell migration and has prognostic value for ERalpha-positive breast cancer metastasis., Data show that in conjunction with ER-related genes, expression of ER protein may provide important predictive outcomes for responses to neoadjuvant chemotherapy and may allow for the identification of patients who could benefit from chemotherapy., Data suggest that P53 dysfunction is prognostically most relevant in ER+ cancers and supports the hypothesis that different predictive or prognostic markers will be needed for different molecular subsets of breast cancer., polymorphisms associated with family environment affect on menarcheal age, these findings offer new insights into the regulation of the breast cancer stem cell phenotype by ERalpha., lower in endometrium of polycystic ovary syndrome group compared to controls, The higher PR-A and ER-alpha gene expression in granulosa cells in patients with endometriosis, compared with patients with tubal infertility, might be a leading cause of ovarian dysfunction due to endometriosis, Estrogen Receptor positivity in non gastrointestinal soft tissue sarcoma was a significant favourable indicator for disease specific survival in women, Lower ER alpha expression is associated with tamoxifen-resistance in breast cancer., Findings suggest that coexpression of CARM1 and ERalpha may provide a better biomarker of well-differentiated breast cancer., The studies reveal the sequence(s) in the ERalpha hinge region that are involved in tethered-mediated actions as well as nuclear localization and attribute important functionality to this region of the receptor, Data show that that bortezomib enhances the fulvestrant-mediated aggregation of the ER in the cytoplasm without blocking the degradation of the ER in the nucleus., The interaction between ERalpha and Akt plays a crucial role in the regulation of proliferative activity in postmenopausal endometrium., Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients., estrogen receptor alpha mediates gene expression changes and growth responses induced by 25 HC in breast and ovarian cancer cells, Results demonstrate that ROSC negatively affects the functional status of ER-alpha, making it potentially useful in the treatment of estrogen-dependent breast cancer cells., Estrogen receptor-alpha polymorphism is associated with fracture., Results showed that changes in both ERalpha and ERbeta expression characterize the transition from normal epithelium to cancer in patients with vulvar squamous cell carcinoma, ER-alpha recruitment in the tethering pathway is dependent on the ligand-induced formation of transcription factor complexes that involves interplay between the proteins from different transcription factor families., Estrogen receptor alpha/beta influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility., This observation suggests that a switch from ERalpha66 to a predominant expression of ERalpha36 may be associated with development and/or progression of human HCC., ERalpha expression was reduced in in Sertoli, myoid and Leydig cells of infertile men., an inherent role for monoubiquitination in estrogen receptor alpha signaling and physiological function of receptor monoubiquitination in the regulation of estrogen induced cell proliferation, gen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells, histone modifications governing TFF1 transcription are mediated by estrogen receptor, Differential expression of 4 out of 5 genes related to estrogen metabolism and action (ESR1, ESR2, PGR and BGN) was confirmed in endometriosis., in breast cancer cells, IGF-2 activates ER-alpha and ER-beta, and modulates their translocation to nucleus, membrane organelles and mitochondria; IGF-2 actions are mediated by the IGF-1R and the insulin receptor, ERalpha and some growth factors may be involved in the tumorigenesis of prolactinoma. ERalpha could potentially be an effective therapy target for treating prolactinoma., The results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine., CYP17A knockdown in H295R cells resulted in less production of both 17alpha hydroxyprogesterone and androstenedione., A comprehensive immunohistochemical study was performed to investigate the protein expression of eight CT genes in 454 invasive ductal carcinomas, including 225 ER/PR/HER2-negative (triple-negative) carcinomas., ESR1 expression did change through the menstrual cycle or in uteri with adenomyosis., JMJD2B is recruited to ERalpha target sites, demethylates H3K9me3 and facilitates transcription of ER responsive genes including MYB, MYC and CCND1, ERalpha gene CG haplotype could be associated with a reduced risk of primary knee osteoarthritis in Mexican mestizo population., these observations show that hypoxia-stabilized HIF-1a induces the repression of the ESR1 gene, which may facilitate hormone insensitivity in the tumor microenvironment., Overexpression of ERalpha gene and enhanced activation of calcineurin in response to estrogen in peripheral blood lymphocytes may contribute to the pathogenesis of female dominant in systemic lupus erythematosus., These results suggest that ERalpha induces the down-regulation of PTEN through PI3K activation in breast cancer cells., Results suggest that co-targeting c-ABL and ERalpha as a combinatory approach may have therapeutic potential for breast cancer., Upon IMS stress, overproduction of reactive oxygen species (ROS) and phosphorylation of AKT triggers estrogen receptor (ER) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease HTRA2., Studies suggest that the development of ERbeta-based therapies may lead to improved drug efficacy., analysis of estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas, ERalpha phosphorylation at serine 118 affects recruitment of unique protein complexes at gene-specific promoters., Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis., Combination of Src kinase inhibitor KX-01 with tamoxifen may present a promising new strategy for clinical management of ERalpha positive breast cancer., no association of rs9340799 with adolescent idiopathic scoliosis predisposition or curve severity, homocysteine promoted hypermethylation of the promoter A region of the estrogen receptor-alpha gene, which may be an important mechanism for the pathogenesis of postmenopausal osteoporosis, TLE1, is a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions., ESR1 expression is correlated with three open reading frames on chromosome 6 in tumours., An association between ESR1 and global anxiety in older women, however these associations varied depending on the anxiety syndrome and the use of hormone treatment., AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription., Differential expression of estrogen receptor alpha and beta transcripts in tissues and in primary culture cells from pubertal gynecomastia., Expression of TLR9 isoforms A and B can be detected in clinical breast cancer specimens. The ERalpha and sex steroid hormones regulate TLR9 expression and invasive effects in the breast cancer cells., Devised a novel flow cytometric method to quantify the expression of ERalpha, HER2, and the activation of ERK1/2 simultaneously in single cells., ER-alpha, which is regulated by miR-26a, is important for liver tumor cell growth., determined the status of ERalpha and ERbeta in the myometrium and leiomyomas, atypical leiomyomas and leiomyosarcomas, concomitantly with the expression of NTS/NTS receptor 1 in these tumors, The ERalpha methylation status in basal-like breast cancer was significantly higher than in sporadic non-basal-like breast cancer, ERalpha and ERbeta may act in opposite directions to regulate the Slug-E-cadherin pathway and to affect invasiveness of nonfunctional pituitary adenoma, Two ER subtypes exhibit different expression patterns in spinal trigeminal nucleus, with higher expression levels of ERalpha than ERbeta, suggesting that estrogens may directly affect trigeminal neuron excitability in humans., This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk., CYP17 gene and ERalpha gene may not be genetic risk factors for endometriosis among southern women in China, The prognostic value of the correlations between the expression of estrogen and progesterone receptors, Ki67 expression and the histological stage, tumor stage, the degree of myometrial and vascular invasion, was investigated., Studying each locus alone, no significant results were drawn for ESR1 and ESR2 genes., single nucleotide polymorphisms in the ESR1 or ESR2 genes do not seem to play a major role in the genetic susceptibility of Alzheimer's disease, 17beta-estradiol induces the expression of KCNK5 via ERalpha(+) in breast cancer cells, and this channel plays a role in regulating proliferation in these cell lines., The menopausal women having heterozygous and homozygous mutants of PvuII or XbaI genotypes were strongly correlated with breast cancer (P<0.01)., associations between PvuII-XbaI haplotype 2 polymorphism and body fat mass in girls were found in recent cohort, non-carriers of this polymorphism are likely to be more vulnerable to fat accumulation in today's obesity promoting environment, than carriers, After calcium supplementation, bone mineral density increased in lactating women with some estrogen receptor genotypes., Estrogen regulates human DBS, which could reduce the risk for duodenal ulcer in women and contribute to sex differences in the prevalence of duodenal ulcer., The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer., ER-alpha XbaI and VDR BsmI genetic polymorphisms had a significant association with the risk of prostate cancer., Consistent with its ability to regulate the levels of ERalpha, expression of RUNX3 inversely correlates with the expression of ERalpha in breast cancer cell lines, human breast cancer tissues and Runx3(+/-) mouse mammary tumors, ER-alpha might have an important role in human papillary thyroid carcinoma, and its overexpression can be studied in routine needle aspirate as a possible marker of malignancy., Data suggest that estrogen receptor loss in estrogen/antiestrogen sensitive cells triggers loss of endocrine dependence and onset of events that change the cell from an epithelial to a mesenchymal type., The genetic variants in the ESR, FTO, and UCP2 genes may be considered as a screening tool prior to bariatric surgery to help clinicians predict weight loss or glycemic control outcomes for severely obese patients., Our data suggest that polymorphisms of the ER alpha and ER beta genes may influence tumor growth, particularly in the passage from in situ to invasive melanoma., ER and PR do not appear to have a role in how dietary folate and vitamin B6 intakes are inversely associated with breast cancer risk, AR is enriched in ER- breast tumors that overexpress HER2., pancreatic Stat3 has a role in ER-mediated suppression of lipid synthesis, Data show that the triple-negative and HER2 subtypes were associated with poorer outcomes compared with the luminal A subtype., the nongenomic PI3K signaling pathway plays a role in estrogen/hERalpha-stimulated hSlo1 gene expression; whereas c-Src activity leads to hSlo1 gene tonic repression independently of estrogen, likely through ERK activation., These data replicate previous associations found between single nucleotide polymorphisms in the 6q25 locus and bone mineral density [BMD(a)] at the hip., Aurora-A phosphorylation of p53 sequesters the protein in the cytoplasm and enhances its interaction with ERalpha in a ternary complex comprising of the three proteins, microRNAs actively control some of the most distinguishing characteristics of the breast cancer subtypes, such as ERalpha itself, Dicer, and growth factor receptor levels, Sata support the relevance of phosphorylation at p-Y537-ERalpha in breast cancers and add further support to the presence of a phosphorylation code for ERalpha in human breast cancer in vivo., The age at disease diagnosis was lower in carriers of the ESR1 rs9340799 A allele compared with GG homozygotes as well as in patients with ESR1 rs2234693 TT and CT genotypes compared with CC homozygotes., Data show that triple-negative breast cancer (TNBC) are larger in size compared with other subtypes and almost all grade 3., Different expression patterns of androgen receptor and ER alpha mRNAs in malignant tissues of oral mucosa suggest an involvement of these sexual hormones in oral cancer, TNF-alpha activates ER signaling in endometrial epithelial cells., Results found that in the Brazilian male population, genetic variations in both estrogen receptors alpha (PvuII and XbaI) and beta (AluI and RsaI) were not relevant to idiopathic infertility., These results suggested a novel regulatory mechanism of let-7 miRNAs on ER-alpha36 mediated nongenomic estrogen signal pathways., These results demonstrate a novel pathway of estrogen regulation of gene expression by cooperation between ER and AP-1 at the distal enhancer element and that AP-1 is involved in estrogen induction of the c-myc oncogene., the ER1 polymorphisms might associate with type 2 diabetes and fasting glucose among Iranian male subjects., A polymorphism of the ESR1 gene is a novel c.453-397C allele-specific and c-myb-dependent enhancer-like cis-acting regulatory variation and could be part of the genetic variations underlying the susceptibility to hepatitis B virus-related liver cirrhosis., We confirmed evidence that discordance of ER/Her2 expression between primary and metastatic breast carcinoma does occur., Annonacin induced growth arrest and apoptosis via ERalpha-related pathways in MCF-7 cells., analysis of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors from an endometriosis tissue microarray model, H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency, The allele of estrogen receptor-alpha identified by XbaI (X) restriction was detected less frequently in the study group compared to the control group., Data from material procured by laser capture microdissection suggest that coordinated expression of ESR1 and XBP1 in breast carcinoma is due to their co-expression in carcinoma cells rather than in the surrounding stromal cells., We conclude that Reed-Sternberg cells in classical Hodgkin lymphoma in children seem to be mainly ERbeta positive and ERalpha negative., These studies identify PITX1 as a new ERalpha transcriptional target., All the enhanceosome components comprising estrogen receptor alpha (ERalpha), FOXA1, and GATA3 are necessary for the full repertoire of cancer-associated effects of the ERalpha., common single-nucleotide polymorphisms inside ER are related to the clinical outcomes of androgen-deprivation therapy in men with prostate cancer, summarizes recent studies on the structure and function of ER-alpha36 and the relationship of ER-alpha36 with cancer, with special emphasis on its function in the resistance of breast cancer to endocrine therapy, Data show that hierarchical clustering based on mRNA expression of estrogen receptors, progesterone receptor and neu receptor by quantitative RT-PCR identified patient groups that were comparable to the subtypes identified by immunohistochemistry., These results suggest a novel negative regulation of estrogen receptor alpha activity and protein by JAK2 in breast cancer cells and indicate a potential new cross-talk, demonstrated that ER-alpha36 positively regulates HER2 expression and the population of ALDH1 positive breast cancer cells, and suggested that non-genomic estrogen signaling mediated by ER-alpha36 is involved in maintenance of breast cancer stem cells, ERalpha physically interacted and functionally cooperated with SIRT1 in breast cancer cells. ERalpha also bound to the promoter for SIRT1 and increased its transcription., Epigenetic alteration of ERalpha gene may play an important role in the pathogenesis of familial breast cancer, This study described the generation of two isogenic breast cancer cell lines, Hs578T-ERalphaLuc and Hs578T-ERbetaLuc, with stable integration of an estrogen responsive luciferase reporter gene., the A allele of SNP12 of ESRa may increase the risk of hypospadias or cryptorchidism., total internal reflection fluorescence microscopy in endothelial cells illustrates that ER46 can topologically conform to a type I transmembrane protein structure, We propose that different variants of IVS1-397 estrogen receptor alpha polymorphism may become additional genetic factor that influences regulatory conditions during diabetes type 1 in females., 14-3-3beta has oncogenic potential in breast cancer via binding to ERalpha and activation of the transcriptional activity of ERalpha., Data suggest that the low-level expression of ESR1 is associated with tamoxifen resistance in ER-positive breast cancer., ERalpha has a role in regulating tyrosine hydroxylase and alpha-synuclein expression; the extent to which oysterol 27-hydroxycholesterol utilizes their pathways to modulate expression levels of these two proteins is characterized., There was no compelling evidence of an association between variant alleles of genotypes estrogen receptors alpha and breast density., The median time of survival in patients with lung cancer depending on the expression of ER alpha was 31 months, while for ER beta was 73 months., 1 of 8 in, aberrantly expressed miRNA-206 may be associated with the development of ERalpha-positive endometrioid adenocarcinoma (EEC)., There is little involvement of genetic variation of the ESR1 gene in modifying risk of coronary artery disease., XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events., When combined with HER2, ESR1 may be prognostic but should not be used for endocrine treatment selection in postmenopausal women with endocrine-responsive early breast cancer., ERalpha gene polymorphisms may be associated with the pathogenesis of schizophrenia in Korean patients., Reduced estrogen receptor is associated with recurrent breast cancer., A combination of CALM1 and ER1 gene polymorphisms might be related to double curve in patients with AIS., analysis did not reveal any association between the ER1 genetic variant and postmenopausal breast cancer risk, either ER-positive or ER-negative disease, Gastrointestinal stromal tumours do not show immunopositivity for ERa or HMB45., Gene expression signatures comprising 24, 51 and 14 genes predictive of ER, PR and ERBB2 status respectively, were investigated., Data suggest that pelvic organ prolapse is associated with higher expression of ERalpha/ERbeta in the pelvic floor of both pre- and post-menopausal women., Chromatin immunoprecipitation identified ERalpha genomic binding activity in estrogen-deprived cells., our study has identified novel aspects of ligand-mediated estrogen receptor alpha and beta interactions underlying the diversity of estrogen-mediated regulation of different cellular functions mediated by ligands of different biocharacter, In breast cancer, estrogen receptor alpha is downregulated by TWIST1 (Twist) through interactions with DNA methyltransferase 3B (DNMT3B) and histone deacetylase 1 (HDAC1)., regulation of ER by Twist could be an underlying mechanism for the loss of ER activity observed in breast tumors, and may contribute to the generation of hormone-resistant, ER-negative breast cancer, Estrogen receptor alpha unstructured transactivation domain (AF1) activity is regulated by S118 phosphorylation-dependent recruitment of PIN1., Data indicate that in myometrium in pregnancy, ER1 and GPR30 mRNA are expressed; ER2 mRNA is undetectable; ER1 protein is undetectable unless 26S proteasome activity is inhibited; estradiol acts via ER1 and activation of ERK/MAPK pathway., Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation., a small increase in the expression of p23 amplifies ER-binding genome wide and, in combination with ER, elicits an invasive phenotype in breast cancer, NF-kappaappaB, acting through two response elements, is required for ER recruitment to an adjacent estrogen response element in the BIRC3 promoter., Genetic variants in ESR1 does not contribute to the development of Lynch syndrome., Expression of PR and ESR1 defines a subgroup of ovarian carcinomas with a favourable prognosis., ER-alpha and PR may be useful markers predicting therapy response in endometrial hyperplasia., The prognostic impact of Akt (Akt1) phosphorylated at threonine308 and serine473, Akt2, Akt3, PI3K and PTEN, alone and in coexpression with ER and PgR in non-gastrointestinal stromal tumor soft tissue sarcomas., Invasive ductal mammary carcinoma type was analyzed for comparative investigation of hormonal receptors (estrogen receptor ER and progesterone receptor PR) and Her2/neu oncoprotein expression., PBX1 is a novel pioneer factor defining aggressive ERalpha-positive breast tumors, as it guides ERalpha genomic activity to unique genomic regions promoting a transcriptional program favorable to breast cancer progression, Thyroid hormone is shown to induce human lung cancer cell proliferation via crosstalk between integrin alphavbeta3 and ERalpha., Colocalization of estrogen receptor alpha 36 isoform with cytoskeleton microfilaments suggests a role of estrogens in cell motility., It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal., ER gene PvuII and XbaI polymorphisms have no major influence on bone mineral density in our group of postmenopausal women., Results demonstrate that estradiol induces growth of human astrocytoma cell lines through ERalpha and its interaction with SRC-1 and SRC-3 and also suggest differential roles of ERalpha on cell growth depending on astrocytoma grade., Amplification of ESR1 in breast carcinoma occurs as low-level amplification., NR2E3 regulates ESR1 via direct binding to the ESR1 promoter with concomitant recruitment of PIAS3 to the promoter in breast cancer cells, and is essential for physiological cellular activity of ESR1 in estrogen receptor (ER)-positive breast cancer cells, Our findings suggest that estrogen signaling could be affected not only in estrogen receptor alpha (ER A)-negative breast cancer, but also in ER A-positive breast cancer due to lack of circadian availability of ER A., Expression of the newly identified estrogen receptor alpha-36 is not limited within breast cancer epithelium, but is equally identified in tumor vasculature, peritumoral fat tissue, lymphocytic infiltrate and stromal fibroblasts., SNPs (HSD17B1 (rs2010750, rs598126 and rs676387), COMT (rs4680), UGT1A1 (rs8175347) and ESR1 (rs9340799)) seem to be related to mammographic density in the same direction of their associations with breast cancer risk, p27KIP1 has a role in node-negative breast cancer, but the interaction with ER and PR is only significant in T1a/b stage, ER-alpha intrinsic DNA binding free energy is identical to that of progesterone receptor B (PR-B) isoform, as expected; this ability serves as a framework for regulating receptor-specific promoter occupancy and thus receptor-specific gene regulation., The predictive value is amplified when the ER status is correlated with the PR status., We have determined the estrogen receptor alpha cistrome defined by a novel method to study DNA-protein interactions in vivo., OD extracts enhance the tumor suppressor p53 expression as a result of an increased binding of ERalpha/Sp1 complex to the p53 promoter region., siRNA-mediated knockdown of Noxa resulted in cell cycle arrest following E2 treatment, indicating that Noxa expression is required for cell cycle progression in ER-positive breast cancer cells., The findings in this pilot study suggest that estrogen receptor 1 (ESR1) gene polymorphisms do not contribute to endometriosis susceptibibility in women., ERalpha repressively modulates the expression of LKB1 at the transcriptional level., identified a locus on 6q25 associated with breast cancer risk in US Latinas; the peak of the 6q25 signal includes the estrogen receptor 1 (ESR1) gene and 5' region, a locus previously implicated in breast cancer, In the Iranian population, genetic polymorphisms of the ER-alpha and ER-beta genes may be involved in the etiology of prostate cancer, Estrogen can repress transcription of HBV genes by up-regulating ER-alpha, which interacts with and alters binding of HNF-4alpha to the HBV enhancer I., The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing testicular germ cell cancer, histological subtype, and risk to metastasis., presence of an ERalpha splice variant, ERalpha36, in ERalpha-positive MCF7 and ERalpha-negative HCC38 breast cancer cells, which localized to plasma membranes and rapidly activated PKC in response to E(2), Data show that phosphorylation of serine 212 enabled estrogen receptor alpha (ERalpha) to regulate a unique set of genes and cellular functions., RASSF1A has a key role in suppressing the transformation of human breast epithelial cells and estrogen receptor alpha positive breast cancer initiation., None or very small amounts of ERbeta were detected, and ERalpha and ERbeta2 mRNA were elevated in the Puumala virus infection patient group., discussion of tissue-specific regulation of gene expression involving ERalpha and ERbeta, ER agonists, estrogen response elements, and epigenetic modification of ER genes; discussion of molecular targeted anticancer therapy with ER agonists [REVIEW], discussion of role of ERalpha/ERbeta in cardiovascular adaptations of uterus during pregnancy; structural basis for functional diversity of ERalpha/ERbeta subtype selectivity of estrogens; and genetic/epigenetic regulation in endothelium [REVIEW], Results indicate that the 2,4- and 2,5-dimethyl derivatives of phenyl vinyl estradiols had the highest relative binding affinity with estrogen alpha receptor., CaM binds two molecules of ER-alpha in a 1, ERbeta AluI A allele presence was the most important independent predictor of hormone therapy-induced increase in flow-mediated dilation while ERalpha XbaI A allele was the only independent predictor of decrease in sCD40L., This study suggested that there was a modest but statistically significant association between the PvuII pp genotype of the ESR1 gene and vertebral fracture in Chinese patients., The ERa PvuII polymorphism is associated with the increased risk of CAD in men of a Chinese population., S6K1 directly phosphorylates and regulates ligand-independent activity of ERalpha, while ERalpha upregulates S6K1 expression., ER/PR and HER2 statuses between primary and liver metastatic lesions of breast carcinoma can be modified after treatment but are stable in most cases during the natural metastatic process., Among the 1% to 9%, 10%, and more than 10% ER IHC-positive patients, 24%, 67%, and 92% were also positive by ESR1 mRNA expression. The average ESR1 expression was higher in the >/= 10% ER-positive cohorts compared with the 1% to 9% or ER-negative cohort., PRSS23 is upregulated by estrogen receptor alpha in breast cancer cells., reduced microRNA-152 can lose an inhibitory effect on DNA methyltransferase, which leads to hypermethylation of the ERalpha gene and a decrease of ERalpha level, a role of non-genomic signaling through the activation of p-ERK1/2 in the hormonal dependence of inflammatory breast cancer by a combination of estrogen receptors, genetic association studies in population of Greek women, These results provide new evidence of the mechanisms whereby estradiol regulates leptin expression in placenta and support the importance of leptin in placental physiology., The estrogen receptor alpha PvuII/XbaI and vitamin D receptor FokI polymorphisms may contribute to the determination of bone mineral density in Turkish postmenopausal women., The presence of the APOE epsilon4 allele, and not the alleles of ER SNPs, is a risk factor for MCIa. Furthermore, APOE genotype seems to predict the conversion from MCIa to AD., genetic association studies in Brazilian women, Data show that 7alpha, 6-hexanyl derivatives of estradiol (compound 13) functions as a mixed agonist/antagonist, inducing only weak estrogen receptos (ER) transcriptional activity while preventing coactivator recruitment and stabilizing ER expression., Significant increases in osteoporosis risk with minor alleles of rs2077647 located in the first exon and rs2234693 located in the first intron, Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-transcription., Our results indicated that expressions of ERalpha and ERbeta correlate with each other and with less aggressive phenotypical features of invasive breast ductal carcinoma., ERalpha25p is a new CaM-binding ligand., The regulation of estrogen receptor alpha signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells., ERalpha/beta heterodimers are growth inhibitory in breast and prostate cells which co-express the two ER isoforms, in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1, epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women, In clinical practice, besides routine detection of ER-alpha and PR in invasive luminal subtype breast cancers, immunohistochemical staining of ER-Beta1 and ER-Beta2 should be considered in order to achieve more useful information., HADHB is a functional molecular target of estrogen receptor alpha in the mitochondria, and the interaction may play an important role in the estrogen-mediated lipid metabolism in animals and humans., PIMT may act as a co-activator in ERalpha-mediated transcription of TFF1 through its recruitment to the promoter via interacting with ERalpha., In the female bipolar disorder a significant association result was found for rs6023059, a single nucleotide polymorphism (SNP) placed downstream of the gene coding for transglutaminase 2 (TGM2)., EGFR overexpression relates to triple negative profile (ER-/PR-/HER2-) and poor prognosis in breast cancer patients in Tunisia, phosphorylation at Ser-118 is required for ER to bind both p38gamma and c-Jun, thereby promoting ER relocation from ERE to AP-1 promoter sites., ER-alpha36 expression was significantly higher in ER-negative tumors than in ER-positive tumors, This meta-analysis provides evidence that PvuII polymorphisms in the ESR1 gene, which encodes for estrogen receptor-alpha, could modify the susceptibility to endometrial cancer., 68.3% of patients were ER-positive, and 71.5% were PR-positive. Among the 28.3% of HER2-positive tumors, the majority (19.2%) stained +++. Almost 50% of the tumors were ER+ PR+ HER2-, which makes this the predominant tumor type., GPER status adds clinically relevant information to ERalpha status in endometrial carcinoma and suggest a potential for new inhibitors in the treatment of metastatic endometrial cancers with ERalpha expression and GPER loss., results indicate that in ER-negative breast cancer cells Src functions as a switch in ERalpha36-mediated biphasic estrogen signaling through the EGFR/STAT5 pathway, Data suggest that ERalpha colocalizes with activated/phosphorylated JNK1 (c-Jun N-terminal kinase 1) at many target gene promoters in nuclei of breast cancer cells exposed to estrogens., Data suggest that lack of palmitoylation renders ERalpha more susceptible to estradiol-dependent degradation, blocks phosphorylation of ERalpha at Ser118, and prevents estradiol-induced ERalpha estrogen-response element occupancy., TWIST expression was inversely correlated with ERalpha expression in both breast cancer cell lines and human breast ductal carcinomas., Her2-tumor-initiating cells-enriched signature was specific to HER2(+), Data indicate that estrogen receptor (ER)alpha and ERbeta immunoreactivity was detected in the nuclei of esophageal squamous cell (41.1 and 97.8%, respectively)., AR and ESR1 have distinct modes of interaction with chromatin and that DNase I hypersensitivity dynamics provides a general approach for predicting cell-type specific cistromes., Based on a limited selection of gene variants, no involvement of SRD5A1, SRD5A2, ESR1, ESR2 or PGR in female pattern hair loss is evident., these data suggest that TTF-2 may modulate the function of ERalpha as a corepressor and play a role in ER-dependent proliferation of mammary cells., Aberrant hypermethylation of ER gene is associated with invasive ductal cell carcinoma of the breast., ERalpha positivity, ERbeta negativity, and AR expressions are associated with a more aggressive phenotype of differentiated thyroid cancer., divergent effects of coregulators on the stable association of estrogen receptor alpha with estrogen response elements associated with the TFF1 and progesterone receptor promoters, increased expression is associated with improved overall survival in patients with adenocarcinoma that underwent surgical resection, The ER-CXCL12-CXCR4 signaling axis may represent a promising target for development of therapeutics for ER+ ovarian cancers., study establishes a role for AIB1 in aromatase inhibitor-resistant breast cancer and describes a new mechanism of ER-alpha/AIB1 gene regulation which could contribute to the development of an aggressive tumor phenotype, Data show that HEK293T cells transfected with estrogen receptor alpha (ERalpha)+/-Galpha(o) revealed that Galpha(o) stimulated phosphorylation of ERK MAP kinases ERK 1/2 and subsequently increased the phosphorylation of ERalpha on serine 118., CAV-1 affected cell growth of lung cancer NCI-H446 cell through the interactions with p-ERK1/2, estrogen receptor and progestin receptor, The mechanism of estrogen-promoted ovarian cancer metastasis may due to the up-regulation of survivin conducted through the ERalpha signalling pathway., A consistent enrichment of PR transcripts, relative to estrogen receptor transcripts, in the bipotent progenitor subfraction in the normal human breast, is reported., There were no statistically significant associations of ESR1 and ESR2 gene polymorphisms with response to treatment., The epithelial component demonstrated the expression for ER-alpha (45.6%, 36 of 79), ER-beta (37.2%, 29 of 78), PR (91.1%, 72 of 79), and AR (10.1%, 8 of 79)., measurement of ESR1 mRNA levels may be predictive of response to endocrine therapy in a manner that is different from the predictive value of ER, Estrogen receptor positive (ER+)BRCA1-related breast cancers show several morphologic and immunophenotypic differences from ER+ sporadic breast cancers., 17beta-estradiol treatment increased the proliferation of MCF-7 cells with a higher ERalpha/ERbeta ratio., A novel mechanism by which overexpression of estrogen receptor (ER) beta through NCoR is able to down regulate ER alpha gene expression, thus blocking ER alpha's driving role on breast cancer cell growth., Major variations in estrogen receptor (ER) measured by ligand binding assay and immunohistochemistry are observed within all ESR1 copy number subgroups and other mechanisms than gene copy number seem to contribute to the ER protein content in the tumors., Estrogen receptor (ER)alpha gene polymorphism using XbaI restriction enzyme influences the perception of back pain in patients with degenerative spondylolisthesis., that hinge domain phosphorylation patterns uniquely inform on the various ER alpha activation mechanisms thought to underlie the biologic and clinical diversity of hormone-dependent breast cancers, Estrogen receptor alpha gene polymorphisms has a role in risk of HBV-related acute liver failure in the Chinese population, attenuated phosphorylation of ERalpha at S118 and S167 significantly affected cellular physiology and behavior in MCF-7 breast cancer cells, resulting in increased growth, migration/invasion, an altered gene expression patterns., The ESR1-PvuII polymorphism emerges as a potential candidate for the early prediction of infertility due to premature ovarian aging., Estrogen receptor alpha gene polymorphism was related to unknown thin endometrium, in which P allele may be the risk and X allele may be its guard factor. The expression of estrogen receptor alpha was decreased in thin endometrium., ESR1 454-397T>C mutation is significantly associated with increased risk of ischemic stroke. [Meta-analysis], Presence of membrane-bound ERalpha expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between membrane-bound ERalpha and EGFR mutation., Differences in uterine immunoexpression of PR, ERalpha and OTR when comparing prostaglandin- to progestagen-based protocols for ovine estrus synchronization., an insight into a feedback loop between ERalpha and p53 and a biological role of p53 in the DNA damage response in ER-positive breast cancers., show that c-Fos and ERalpha can cooperate in regulating E2F1 gene expression by binding to regulatory elements in the E2F1 promoter, The microsatellite ESR1_TA in the ESR1 gene seems to have no association with breast cancer among African American or Nigerian women., The XbaI polymorphism was clearly associated with a reduction in endometrial thickness in women with breast cancer treated with aromatase inhibitors., ERalpha gene polymorphism is correlated with the pathogenesis of missed abortion. Alleles P and X may be susceptibility genes., This study found a significant effect of estrogen receptor alpha (ESR1) TA microsatellite repeat number on left hand 2nd, Increased TRPV6 expression is a feature of estrogen receptor (ER)-negative breast tumors., The associations of 6 selected polymorphisms in three genes, The results indicates that there appears to be an influence of ESR1 codon 594 genotypes on genetic susceptibility to breast cancer., testable hypotheses regarding a role of genetic variants in ESR1 in dysfunctional human maternal parenting., expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer, BCA2 is therefore a newly identified transcriptional target of estrogen receptor., 17beta-estradiol stimulation induces the recruitment of PAD2 to target promoters by ERalpha, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation., ERalpha phosphorylation at Y537 by Src triggers E6-AP-ERalpha binding, ERalpha ubiquitylation, promoter occupancy, and target gene expression., The XbaI polymorphism is correlated to BMD at diverse skeletal sites. PP had a protective role for the lumbar spine but might be a risk factor for the femoral neck., Estrogen receptor alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis., Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms are not associated with endometriosis risk., These results suggest that ERalpha is a critical regulator of chondrocyte proliferation and maturation during skeletal development, mediating longitudinal bone growth in vivo., Activation of the PKA signaling pathway alters the transcriptome by redirecting ERalpha to new transcriptional start sites, resulting in altered transcription and tamoxifen resistance., Both ACTN4 (full length) and ACTN4 (Iso) potentiate basal transcription activity and directly interact with estrogen receptor alpha, although ACTN4 (Iso) binds ERalpha more strongly., interaction of Delta(5)-androstenediol with ERalpha and ERbeta, These experiments further define the molecular mechanism of estrogen's bone-protective effects by inducing osteoclast apoptosis through upregulation of MMP3 and FasL cleavage., ASPP 049 from C. comosa induced osteoblastic cell proliferation and differentiation through ERalpha-, Akt-, and GSK-3beta-dependent activation of beta-catenin signaling., Characterize an estradiol-regulated interaction of NPPA with ERalpha in cardiomyocytes., findings unveil a potential tumor-suppressor role of ERbeta in ovarian carcinogenesis, which could be of potential clinical relevance for the selection of the most appropriate treatment for patients, Expression of ER-a is positively correlated with positive rates of AMA-M2 antibody, Sp100 and gP210 in tissues of primary biliary cirrhosis patients., The predictive capacity of 32 genome wide association studies-detected common variants for breast cancer risk, alone and in combination with classical risk factors, and for tumours with different hormone receptor status, was investigated., Overexpression of antizyme (AZ), an ornithine decarboxylase (ODC) inhibitory protein, suppressed ERalpha expression, suggesting that ODC plays an important role in regulation of ERalpha expression., Immunohistochemical evaluation of TRAP1 together with ERalpha provides significant prognostic information. TRAP1 alone is significantly associated with chemotherapy response and overall survival., Data suggest that estradiol counters oxidized LDL by restoring dimethylargininase activity and preventing loss of eNOS (nitric oxide synthase 3) in arterial endothelium acting through ERalpha (but not ERbeta or G protein-coupled estrogen receptor)., The aim of this study was to assess the expression of estrogen receptors alpha and beta in paratesticular tissues in a group of boys with and without cryptorchidism., The genomic and transcriptional cross talk between AR and ERalpha signaling in a luminal breast cancer cell line, was investigated., Immunohistochemistry revealed very low expression of ERalpha, whereas all informative tumors expressed ERbeta1 and ERbeta2 in parathyroid adenomas., Data indicate that the persistent organic pollutants (POPs)-related receptors estrogen-, androgen- and aryl hydrocarbon-receptortransactivities can be used as effect biomarkers., the 5'-UTRs of the E isoforms post-transcriptionally control ERalpha expression mainly through translational repression, The presence of ERalpha in Sertoli and Leydig cells in normal human testis demonstrated in this study suggests that estrogens may affect testicular function., Estrogen receptor-alpha, RBCK1, and protein kinase C beta 1 cooperate to regulate estrogen receptor-alpha gene expression., The relationship between ERRgamma and ERalpha status could be a predictive marker for the treatment of uterine endometrial cancer., Data suggest a role for the ERalpha, ERbeta and GPER in the estrogenic disruption of acinar formation., Data suggest that 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene [MBP] has key contacts with amino acids in estrogen receptors ERalpha and ERbeta., Estrogen receptor alpha signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2, ERalpha binds to the DEK promoter., Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97, Polymorphic variants of ESR1 gene with TA-repeats could be related to dysfunction of the ovaries and infertility, which requires additional studies., the XBAI polymorphism in the estrogen receptor alpha gene was observed at a higher mutated homozygous frequency in women with dense breasts, Interaction between genetic and environmental factors may help to explain nonreplication in genetic studies of hypospadias., Variants on ESR1 gene is associated with prostate cancer., findings show that ERalpha methylation is correlated with poor prognosis subtypes of breast tumors in Iranian patients and may play an important role in pathogenesis of the more aggressive breast tumors, Study sequence rules of estrogen receptor alpha-DNA interactions using dual polarization interferometry and computational modeling., genetic association study in population in China, p allele of the ESR1 Pvu II polymorphism is a potential biomarker of logical memory decline among aging women., Breast cancer mRNA levels of ESR1 and HER2 predict response to neoadjuvant chemotherapy and are significantly associated with long-term outcome., DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells, the polymorphic genotypes of BGLAP, ER1, Col1A1 and CALCR are not found to be associated with osteoporosis in a single form but found to be associated in combined forms., these results demonstrate a novel role for cohesin in estrogen-mediated regulation of MYC and the first evidence that cohesin plays a role in ERalpha binding, In Brazilian population evaluated results have demonstrated that the genetic variation in ESR1 gene (PvuII polymorphism) is associated to POF risk., these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor., The ESR1 polymorphism rs3798573 A/G was associated with risk of endometriosis and infertile endometriosis in Han women from central China., Data suggest that CAC1 (cullin domain-containing protein 1), in association with LSD1 (lysine-specific histone demethylase 1), functions as an ERalpha corepressor and may be involved in drug resistance in breast cancer., Data indicate that estrogen receptor alpha, estrogen receptor beta, progesterone receptor and androgen receptor may be partly involved in gastric carcinogenesis but their clinicopathological and prognostic significance appears to be limited., ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women., ESPR1 polymorphisms are associated with adolescent behavior styles., mutant p53 protein binds to the promoter of ESR1 through direct interaction with HDAC1 and indirect interaction with DNMT1, MeCP2 proteins in the ER-negative MDA-MB-468 cells., Point mutants in the estrogen receptor alpha GalphaI-binding domain provide genetic segregation of nonnuclear from nuclear function., ESR1 PvuII (C>T) polymorphism places pre-menopausal breast cancer women at risk for breast cancer., genetic association studies in population of women in Brazil, Data indicate there was a HIF-1alpha-dependent cancer stem cell (CSC) increase in ER-alpha-positive cancers following hypoxic exposure., The findings reveal a tumor suppressive role of hsa-miR-196a2 through regulation of TP63 by ERalpha and/or ERK2 signaling., Estrogen receptor-alpha36 may be an important biomarker for diagnosis, prognostication, and treatment choice in endometrial carcinoma., Identifying novel kinases which modulate Estrogen Receptor alpha activity is relevant to therapeutics. LATS2 modulates Estrogen Receptor alpha-regulated gene transcription, through direct and/or indirect interactions with Estrogen Receptor alpha., The frequency of ESR1 amplification in breast cancer is low when measured by FISH in large sections. ESR1 gain and amplification in breast cancer may be associated with older age and poorer outcomes., we identified Caspase 3, BAG1 and BAG3 as key targets of ERalpha in neuronal cells that may play a role in ERalpha-mediated neuroprotection., Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans., ESR1 gene and insulin resistance remission are associated with serum uric acid decline for severely obese patients undergoing bariatric surgery, the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported., The expression of deltaEF1 is up-regulated by 17beta-estradiol (E2) in MCF-7 cells in an ER-alpha-dependent manner., Data indicate that the prognostic value of Akt2 increases with higher oestrogen receptor (ER) expression, motivating further mechanistic studies on the role of Akt2 in ER+ breast cancer., WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression., Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K activations resulting in endometrial carcinoma., Epigallocatechin gallate downregulates ER-alpha and explains the inhibitory action of EGCG on the proliferation of ER+ PR+ cancer cells tested., The expression of ER protein in superficial and deep ectopic tissues was significantly lower than in eutopic tissues of adenomyosis., Short-term folate supplementation in physiological doses decreases plasma homocysteine but has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma., Genetic predispositions and the short- and long-term effects of hormonal therapy on bone mineral density in girls with functional hypothalamic amenorrhoea., Taken together, our findings offer evidence that in human breast cancer RhoB acts as a positive function to promote expression of ERa and PR in a manner correlated with cell proliferation., The study indicates a positive link between hNIS and ER expression in breast cancer., Moreover, subgrouping of Luminal A-type breast cancer samples according to ERE activity revealed that ERalpha mRNA expression correlated with ER target gene mRNA expression in the high-, but not the low-, ERE-activity group., The article reviews the relationship between polymorphism of sex hormone-related genes (CYP17, CYP19, CYP1A1, COMPT, ERalpha, ERbeta and others)., Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor beta, The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer., Response to trastuzumab is correlated to HER2 mRNA levels only in ESR1-positive tumors. This study adds further evidence to the different biology of both subsets within the HER2-positive group., our results suggest that the detection of ESR1/PGR/ERBB2 mRNA levels by RT-QPCR is a better approach for subtyping breast cancer and predicting the prognosis., HDAC3 is necessary for ERalpha mRNA stability, and is involved in the estrogen-dependent proliferation of ERalpha-positive tumors., ERalpha is a positive regulator of Runx2-I transcription., In this study ribosome display has been used to reassess the estrogen receptor alpha and beta for new and enlarged peptide recognition motifs, leading to the discovery of a potent and highly evolved PXLXXLLXXP binding consensus., polymorphisms of rs3798759 may be a risk factor for female patients with schizophrenia, and haplotypes C-A-G and C-G-G may be risk factors for schizophrenia., Data show that ER-alpha (nuclear) was detected in only 4 (9 %) of patients and not statistically significant, and presence of ER-beta (nuclear) was associated with favourable survival, whereas the presence of ER-beta (cytoplasm) was associated with a poor survival., The suppression of ERalpha by the upregulation of let-7 expression may be a promising strategy., ESR1 is associated with a distinct tumor subtype defined by estrogen receptor-negative status in male breast cancer patients in Italy., meta-analysis of 10 studies involving Chinese Han population suggests the CC genotype of the ESR1 rs2234693 polymorphism is significantly associated with increased risk of coronary heart disease(CHD)in males only; there was no evidence of a significant association between the ESR1 rs9340799 polymorphism and CHD risk, ER alpha and ER alpha-isophorm 36 estrogenic transcriptional effects are opposite., In female mice, perinatal exposure to low dose of BPA resulted in increased ERalpha mRNA expression and high fat diet resulted in elevated ERalpha expression among females that were exposed to the high dose of BPA early in life. There were no changes in males., There is an association between ESR1 polymorphisms and some ART parameters such as the level of E2 on the day of hCG administration and the quality of the embryos., Haplotypes consisting of these two polymorphisms in ESRalpha may be strongly associated with schizophrenia, MCF-7/tamoxifen resistant cells possess overexpressed ER-alpha 36 and EGFR, but down-regulated ER-alpha 66., Glutathione peroxidase, Complex V, Complex III, Complex II, Complex IV, AKT, SAPK, and ERalpha were significantly and positively correlated with ERalpha/ERbeta ratio, ESR1 single nucleotide polymorphism is a predictor of diabetes mellitus, type 2 in hypogonadal men., IGFBP-2 not only modulates IGFs and directly regulates PTEN but also has a role in maintaining ER-alpha expression., PvuII polymorphism (rs2334693) is associated with diminished ovarian reserve., ligand dynamics directs unique signaling pathways and reveals a new role of the DBD in allosteric control of ERalpha-mediated signaling, Data suggest that the ERalpha status of mammary cells dictates whether KISS1R may be a novel clinical target for treating breast cancer metastasis., Estrogen receptor alpha regulatory mechanisms in breast cancer gene expression., As Pin1 impacts both ERalpha protein levels and transactivation function, these data implicate Pin1 as a potential surrogate marker for predicting outcome of ERalpha-positive breast cancer, an intronic variant in ESR1 (rs9322336) was associated with increased risk of musculoskeletal toxicity-related exemestane discontinuation in breast cancer treatment, Results indicate that elevated ER-alpha36, a variant of ER-alpha, concentration is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen (TAM) therapy., Data suggest that 17 beta-estradiol enhances the the glucose uptake, activates PI3K/Akt signaling pathway, leading to translocation of glucose transporter 4 to the plasma membrane in an ERalpha-dependent manner., present study reveals that neither PvuII nor XbaI polymorphisms in the estrogen receptor alpha gene are associated with onset and progression of puberty, study showed association between ESR polymorphisms and cognitive decline or specific areas in cognitive profile., ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium., Wanted to identify estrogen receptor alpha (ERalpha) interacting proteins in Tamoxifen treated MCF7 cells. Using a GST-pull down assay with ERalpha ligand-binding domain and MS-based proteomics approach we identified Profilin1 as a novel ERalpha interacting protein., findings show ESR1 is an independent positive prognostic factor for survival in early-stage non-small cell lung cancer patients; patients with ESR1 high tumors did not benefit from adjuvant chemotherapy, ERa and pAR210 are differentially expressed in hormone-naive (HN) and castration-resistant prostate cancers and that high levels of AR, ERb and pAR210 in HN prostate cancer correlate with a poor clinical outcome., Study provides further evidence of functional interplay among NRF2, AHR and ERalpha signaling pathways through altered p300 recruitment to NRF2-regulated target genes., Findings suggest that estradiol and T regulate arginine-vasopressin (AVP) expression in SH-SY5Y cells through ERs, exerting a stimulatory action via ERalpha and an inhibitory action via ERbeta., The scanning and typing of ERalpha polymorphism in girls with precocious puberty has uncovered several potentially meaningful polymorphisms., Impairment of ERalpha association to ubiquitinated species strongly affects E2-induced ERalpha transcriptional activity., PvuII (C>T) and rs3020314 (C>T) polymorphisms in estrogen receptor 1 may be risk factors for endometrial cancer, these findings demonstrate that ERalpha is a major driver of growth in tamoxifen-resistant breast cancer cells, Results suggest that the polymorphisms of ESR1, ESR2 and FSHR genes did not result in differences in the genotype distribution when obese non-polycystic ovary syndrome population were compared with the non-obese population, The results suggest that the G-quadruplex formation in the coding region of the hERalpha mRNA impacts folding and proteolysis of hERalpha protein by slowing down or temporarily stalling the translation elongation., ER, COX-2 and aromatase are expressed in endometrial neoplasms, suggesting their involvement in tumor development and progression, ESR1 can bind to genomic locations with closed chromatin, inducing chromatin opening in an estradiol-dependent manner., Variants in ESR1 and PARP1 modify effect of passive smoking on breast cancer risk., Data indicate that the menstrual cyclic expression of bcl-2 could be controlled by either direct binding of estrogen receptor alpha (ERalpha) to estrogen-responsive element (ERE) in the c-Jun promoter or the interaction of ERalpha with c-Jun., ERalpha gene XbaI polymorphism may modify individual susceptibility for breast cancer in a Portuguese population., Expression of the progesterone and Estrogen Receptors can significantly affect therapeutic decisions in selected patients with endometroioid endometrial cancer., A total of 10 markers in the ESR1 gene show association with migraine in a Norfolk Island pedigree., Mutation of the penultimate Threonine of ERalpha (T594) strongly enhances estradiol-dependent dimerization and transactivation., Expression of JMJD2A in infiltrating duct carcinoma is higher than in fibroadenoma, and is associated with ARHI, p53 and ER, Studies indicate that the biosensing strategy is based on the protection of DNA duplex from exonuclease III (Exo III)-mediated digestion by specific binding of estrogen receptor (ER) to its DNA response element., Data show that the expressions of ER-alpha, PR, LIF, VEGF, iNOS and CB1 in fallopian tube and chorionic villi of tubal pregnancy were not altered by exposure to levonorgestrel emergency contraception., Lower expression of ER-alpha66 is associated with the development of endometrial hyperplasia in polycystic ovarian syndrome patients., The ESR1 gene was identified as a candidate tumor suppressor gene in HCC and further validation is warranted., Estradiol and IGF-I induced the rapid association of ER to IGF-IR., Hepatic nuclear ER-alpha expression percentage (staining index) is lower in patients with nonalcoholic steatohepatitis when compared to simple steatosis and normal liver., Negative estrogen receptor status was strongly associated with locoregional recurrence after accelerated partial breast irradiation in early-stage invasive breast cancer., show gender-specific transcriptional control of UGT1A genes in jejunum and colon, which is repressed by ERalpha and the recruitment of HDCA 1 and 2 to the UGT1A promoter sequence in females, overexpression of ERalpha mediates apoptosis in ERalpha-negative Hep3B cells by the binding of ERalpha to SP1 protein., The aim of this study was to evaluate the effect of two polymorphisms in the estrogen receptor alpha, PvuII and XbaI, on the development of prostate cancer within Slovak population., The risk factors for breast cancer were more prevalent in women with high breast density but without significant associations with ESR1 polymorphisms., Estrogen receptor-alpha mediates multidrug resistance associated protein 3 expression following 17alpha-ethynylestradiol administration., The PvuII polymorphism in the ESR1 gene may be a risk factor for uterine leiomyoma. [Meta-analysis], Estrogen receptor alpha expression is upregulated in the surrounding ovarian tissues of patients with endometrioma compared to controls., AIB1 exerted its effect on epithelial mesenchymal transition through its interaction with ERalpha, which could directly bind to the ERalpha-binding site on the SNAI1 promoter., There was no association between the PvuII polymorphism and stroke severity and short-term outcome in the studied female stroke population., This work not only identifies these late-activated genes as bona fide ERalpha targets but describes a novel mechanism for their periodic activation., Estrogen receptors alpha and beta and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules., The two ESR1 SNPs, Pvu II and Xba I, are not commonly associated with premature ovarian failure in Serbian women and may not contribute to the genetic basis of the condition., A significant difference in the allele frequencies of XbaI., Data suggest that ESRA activity is modulated in breast cancer via various mechanisms, Data suggest that FOXP1 (forkhead box P1) and FOXA1 (forkhead box A1) are primary ESR1 target genes and critical transcription factors that regulate ESR1 activity in breast cancer. [REVIEW], Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 was lower in patients with estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors., The recruitment of GR to ERalpha-binding regions (EBRs) requires assistance from ERalpha and FOXA1 and is facilitated by AP1 binding within the EBRs., These results clarify the relationship between ER-alpha and PDZK1, propose a direct relationship between PDZK1 and IGF1R, and identify a novel oncogenic activity for PDZK1 in breast cancer., Frequencies of p and x alleles in ER-alpha gene PvuII and XbaI polymorphisms were more prevalent among fertile men compared with infertile oligoasthenoteratozoospermic men., the expression of ERalpha prevents cells from apoptosis, Glucose-regulated protein 94 is a downstream effector of ER-alpha36-mediated oestrogen signalling, and may be involved in ER-alpha36 function during gastric carcinogenesis., ERalpha overexpression significantly inhibited cell growth and proliferation, blocked cell entry into the G1/G0 phase and promoted cell apoptosis., Pumpkin seed extract downregulates ER-alpha and upregulates progesterone receptor in the MCF-7 breast cancer cell line., Specific binding of ER (alpha and/or beta) to ERETTR was demonstrated by EMSA and supershift assays confirmed the binding to ERalpha and/or ERbeta, Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2., study suggest that SNPs in sex steroid related genes, known to affect gene expression (rs2747648 in ESR1) and enzymatic activity (Leu89Val in SRD5A2), seem to be associated with ALTs in a general population., LXRbeta has nonnuclear function in endothelial cell caveolae/lipid rafts that entails crosstalk with estrogen receptor alpha., Retinoic acid receptor alpha may be a novel therapeutic target and a predictive factor for estrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen., Data indicate that receptors (ERs) ERalpha and ERbeta showed significantly decreased mRNA and protein expression levels in endometrial carcinoma as compared to normal endometrium., Transcription factor Ets1 cooperates with estrogen receptor alpha to stimulate estradiol-dependent growth in breast cancer cells and tumors., Results suggest a possible role of ERalpha in male infertility., Genotypes of these single nucleotide polymorphisms of ESR1 and RANKL may help us predict the osteoporosis risk in menopausal women., Our results support a role for ESR1 in the etiology of PPD, possibly through the modulation of serotonin signaling., ESR1 gene deletion and amplification do not constitute per se prognostic markers, instead they can be classified to distinct prognostic groups according to their protein-mediated functional status., the results show that the cervical malignant cells tend to loss the ER-alpha but maintain the ER-beta actively expressed, motivate a cooperation model of ESR1 and SP1 in regulating cell cycle arrest, and a hypothesis that their overactivation in non-hyperdiploid multiple myeloma disrupts proper regulation of cell cycle arrest, ESR1 rs2234693 and rs9340799 were not significantly associated with the risk of decline on any of the cognitive tasks., MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis., ESR1 gene dosage in the entire group of breast cancer patients correlated with higher T stage and lymph node involvement., 1p11-rs11249433 polymorphism is involved in breast cancer susceptibility and confer its effect primarily in estrogen receptor-positive and progesterone receptor-positive tumors., Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen., Significantly increased estrogen receptor level was found in patients with juvenile angiofibromas., Findings suggest a novel pathway in which ERalpha signaling regulates miR-190a expression, causing inhibition of PAR-1 expression, correlated with inhibition of cancer metastasis in breast cancer., chronic cadmium exposure stimulates the expression of SDF-1 by altering the molecular interactions between ERalpha, c-jun and c-fos., Expression of HER4 JM-a/CYT2 isoform relate to survival of bladder cancer patients only if the tumors do not express ESR1., The expression of the estrogen receptor was found in 18% of salivary duct carcinoma patients., ESR1 amplification is independent of known clinicopathological factors related to poor prognosis and PTEN, p53, HER2, MLH1, and ARID1A protein expression, suggesting ESR1 amplification may be an early event in endometrial carcinoma development., Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ESR1 (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ESR1 alone., The estrogen receptor alpha is the key regulator of the bifunctional role of FoxO3a in breast cancer motility and invasiveness., The GFP-GRER exhibited cytoplasmic localization in the absence of ERalpha ligands and translocated to the nucleus in response to stimulation with ERalpha agonists and antagonists, data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer, Did not find any significant correlation between ER-alpha expression and histopathological and biochemical findings in chronic hepatitis C patients., Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation., anti-ERalpha antibody serum immunoreactivity was detected in 42% of patients with systemic sclerosis., CTCs frequently lack ER expression in metastatic breast cancer patients with ER-positive primary tumors and show a considerable intra-patient heterogeneity, which may reflect a mechanism to escape endocrine therapy., The loss of TBK1 expression parallels the loss of ERalpha expression, in turn helping drive an aggressive breast cancer phenotype., Mutations of putative estrogen receptor alpha and/or nuclear factor Y binding sites markedly reduced promoter activity., RhoA and RhoC play different, but clear, roles in ERalpha signaling in breast cancer cells., these results demonstrate that knockdown of HOXA7 in MCF7 cells significantly decreased cell proliferation and ERa expression., ERalpha and ERbeta levels were inversely correlated, and the downregulation of ERalpha and upregulation of ERbeta may indicate unfavorable prognosis of esophageal squamous cell carcinoma, Our results demonstrate the predictive value of the RS for clinical response to neoadjuvant exemestane therapy in postmenopausal women with estrogen receptor-positive breast cancer., Data suggest that SMYD2-mediated estrogen receptor alpha (ERalpha) protein methylation and p300/cAMP response element-binding protein-binding protein-dependent ERalpha acetylation play an important role in the estrogen-induced gene expression profiles., similarly to the situation for the ovary, a diagnostic panel of HNF-1beta and ER may be considered for separating clear cell carcinoma from endometrioid and serous carcinoma of the endometrium, Meta-analytically combined evidence from the present genotyping and the literature showed that rs2295193 polymorphism in ESR1 is not a major genetic susceptibility factor in Anorexia Nervosa., Progesterone receptor and estrogen receptor alpha expression are discordant in different distant breast cancer metastases., Estradiol mediated phosphorylation of ESR1 is mechanism to potentiate transcription from an estrogen response element., Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48., the present study demonstrated that both ERa and ERbeta were sufficient to inhibit PPARgama and provide a valuable therapeutic option for the treatment of Hepatocellular carcinoma patients., Our results provide additional insights into the opposing roles of the ESR1 and FLJ43663 genes in breast cancer onset and progression., ERalpha XbaI polymorphism is associated with an increased risk of Alzheimer's disease in Chinese population, Genetic variants in ERalpha were not associated with metabolic syndrome or its components, in a group of 250 Lebanese Caucasian elderly participants, a group with a high prevalence of metabolic syndrome., It was concluded that estrogenic signals exert malignant transformation capacity of cancer cells, exclusively through non-genomic regulation in female germ cell tumors., A significant effect of ESR1 genotypes was observed for the donepezil-treated alzheimer patients, among which those carrying at least one copy of P and X alleles showed a significantly lower cognitive decline than the noncarriers., No association was found between ESR1 XbaI or ESR1 PvuII single nucleoptide polymorphism and idiopathic scoliosis in Caucasian females., Immunohistochemical expression of ERalpha, ERbeta, and TFF1 in type I and II ovarian tumors., marker of main subtypes of invasive breast cancer in China, It mediates direct and indirect regulations in bone metabolism.(review), Aurora-A represents a prognostic marker in ESR1-positive tumor and a critical therapeutic target in tamoxifen-resistant breast cancer., Data show that estrogen receptor 1 (ESR1) mRNA as assessed by qPCR represents a reliable method for detecting ESR1 expression in non-small cell lung cancer (NSCLS) and that ESR1 expression is an independent prognostic factor in metastatic NSCLC., Activating mutations in ESR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy., Ligand-binding domain mutant forms of ESR1 mediate clinical resistance to hormonal therapy., The discovery of sub-isoforms of ER alpha and beta has further complicated our understanding of how the interaction between ERs and its ligands contribute to the development of disease, IL-6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the estrogen receptor alpha isoform and SRC-1 (NCOA1)., This study provides a deeper understanding of ERbeta's role in breast tumors that coexpress both ERbeta and ERalpha and supports an emerging bi-faceted role of ERbeta., Experiments in breast cancer cells indicated constitutive, ligand-independent transcriptional activity of the D538G estrogen receptor, and overexpression of it enhanced proliferation and conferred resistance to tamoxifen., The expression of both ERalpha and ERbeta in human fetal brown adipose tissue suggests a role for estrogen in its development, primarily via ERalpha., NgBR is highly associated with ESR1-positive/HER2-negative breast cancer., Data indicate that the Cyclopia extracts displayed estrogen receptor alpha (ERalpha) antagonism and estrogen receptor beta (ERbeta) agonism when ER subtypes were expressed separately, however, when co-expressed only agonism was uniformly observed., These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1., The potential association of spontaneous abortion with the ESR1 gene variations (PvuII and XbaI) in fetal tissue, was studied., Variations in the ERalpha gene affected the BMI in women with High breast density, who already are at increased risk for Breast Cancer., Studies indicate that changes in oestrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2) expression may occur during the natural history of breast cancer., Neither the haplotype nor the three ESR1 SNPs were associated with EDs, BN, AN, or restricting type AN., Data suggest that ESR1 (estrogen receptor 1) regulates cell cycle by suppressing expression of p53/p21 (tumor protein p53/cyclin-dependent kinase inhibitor 1A protein) and up-regulating proliferating cell nuclear antigen (PCNA)., NCOA3 is a selective co-activator of estrogen receptor alpha-mediated transactivation of PLAC1., calretinin immunoexpression and the hormonal status for estrogen receptors (ER), progesterone receptors (PR), and ERRB2, in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors, were studied, serum ERalpha-mediated bioactivity is associated with increased breast cancer risk in post-menopausal women, Adiponectin modulates breast cancer cell growth, providing evidences on the cell-type dependency of adiponectin action in relationship to ERalpha status., ER-alpha expression in uterine serous carcinoma is associated with advanced stage tumors and a significantly worse prognosis, results demonstrate that, while ER signaling acts synergistically with Wnt3A in promoting osteogenic differentiation, Wnt3A may crosstalk with ER signaling by up-regulating ERalpha expression and down-regulating ERbeta expression in MPCs., Overexpression of estrogen receptor alpha and beta enhances endometrial carcinoma cell migration, invasion and proliferation., PRKCA activity suppresses the level of ER-alpha expression by inhibiting c-JUN phosphorylation., ER and HER2 are useful markers in core needle biopsies, providing a reliable base for preoperative decisions in neoadjuvant chemotherapy, and may be omitted on surgical specimens with certain precautions and exceptions., Estrogen receptor alpha in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3., genistein treatment produces cell cycle arrest and an improvement of mitochondrial functionality in T47D cells with a low ERa/ERb ratio, but not in MCF-7, PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression., PHB lies downstream of ERalpha and mediates estrogen-dependent Paclitaxel resistance signaling cascades, ESR1 polymorphisms are associated with susceptibility to breast cancer., ESR1-positive epithelial ovarian cancer tissues had lower expression of lnRNAs compared to ESR1-negative tissues., Rs9340799 of ESR1 and one haplotype formed by the two polymorphisms of the ESR1 were significantly associated with bone mineral density in postmenopausal Mexican-mestizo women., ALTTO ineligibility did not change when HER2 testing was performed ... a dual antibody ER assay had fewer false-negative test results than an assay with a single antibody., Authors first report that these SNPs (rs2077647, rs9340799, rs2234693, rs1801132 and rs2228480) in estrogen receptor alpha can influence the outcomes of hepatitis C in a high-risk Chinese population., we show evidence for the temporal selection of functional ESR1 mutations as potential drivers of endocrine resistance during the progression of ER(+) breast cancer., The values and the distribution of the ER and PR taken from the biopsies made in the patients with mammary carcinoma are influenced by the age and menopausal status., Letrozole was effective for ovarian cancers with abundant expression of ERalpha. Inhibition of angiogenesis and of ascites production appeared to contribute to prolongation of the survival period., MTA1-TFAP2C or the MTA1-IFI16 complex may contribute to the epigenetic regulation of ESR1 expression., meta-analysis indicated elected PvuII polymorphism of ER-alpha was a risk factor for prostate cancer development, In aP2-Cre/ERalpha(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus., ESR1 repression by SENP2 is independent of its SUMO protease activity., An association between ESR1 rs9340799 polymorphism and infertile women with endometriosis., SNPs in ESR1 (rs2234693), ESR2 (rs2987983), CYP17A1 (rs743572), and CYP19A1 (rs700519) indeed contribute to breast cancer susceptibility among North Indian women., Methylation status of DNA sequences at ERalpha binding sites is tightly coupled with ERalpha activity., RNF31, via stabilizing ESR1 levels, controls the transcription of estrogen-dependent genes linked to breast cancer cell proliferation., SUPT6H is a new epigenetic regulator of ERalpha activity and cellular differentiation., Results demonstrate that degradation of proteins such as ESRa expressed in activated blastocysts is involved in successful implantation., Regulation of TRIM-21 expression occurs through an ERalpha-dependent mechanism, a pathway that was observed to be overactive in SLE patients., The data show a clear difference in ER expression between lobular and ductal breast cancer., FOXA1 is a tumor suppressor in endometrial cancer and has a possible interaction with estrogen receptor alpha., Overexpression of DNMT1/3a was correlated with promoter hypermethylation and reduced expression of estrogen receptor-alpha and BRCA1., PKM2 acts as a transcriptional coactivator for ERalpha and small-molecule PKM2 activators inhibit ERalpha transcriptional activity and reduce E2-induced cell proliferation., Immune escape mechanisms in ERalpha breast cancer may be facilitated through an ERalpha suppressive mechanism on IFN-gamma signaling., The present study aimed to gain further insight into the DNA methylation patterns of alternative promoters of the steroid receptor genes ESR1, ESR2 and PGR in intestinal deep endometriosis., Our findings suggest that ESR1 and C6orf97 gene polymorphism is associated with fracture and vertebral fracture risk in Chinese postmenopausal women., ESR1 PvuII T allele may increase the risk of hip fracture and that the XbaI polymorphism is not associated with hip fracture, [review] Estrogen resistance due to mutations in the estrogen receptor alpha (ESR1) gene have been described. Their clinical presentations are similar to that of aromatase-deficient men and women., ERbeta and CXCL12/CXCR4 expression in lung adenocarcinoma depends on sex and hormonal status, which may partly explain the sex and hormonal differences in lung cancer behavior., Impairment of ERalpha signal-mediated OLFM4 expression promoted the malignant progression of endometrioid adenocarcinoma., Silencing, by methylation, of the promoter region of the ESR1 affects the expression of the estrogen receptor protein in tumors of breast cancer patients; high methylation of ESR1-DNA is associated with estrogen receptor negative status which., miR-222-3p plays a significant role in the regulation of ERalpha expression and could be potential targets for restoring ERalpha expression and responding to antiestrogen therapy in a subset of ECs., Data show that erythropoietin receptor (EPOR) protein is expressed in breast cancer cells, where it appears to promote proliferation by an EPO-independent mechanism in estrogen receptor alpha (ERalpha) expressing breast cancer cells., Estren and ginsenoside Rg1 activate ESR1 via phosphorylation at Serine 118 in a ligand-independent manner., TT variant of estrogen receptor alpha polymorphism may be associated with enhanced inflammatory response, IQGAP1 binds to ERalpha and modulates its transcriptional function, ER-alpha36-mediated rapid estrogen signaling plays an important role in regulation and maintenance of ER-positive breast cancer stem/progenitor cells, There are comparable levels of EESR1, total ERK1/2 and active ERK1/2 in the stroma and epithelium of proliferative phase endometrium., Trim21, an estrogen receptor coactivator, induces MYC oncogene by removing repressive CoAA through E2-dependent degradation of CoAA., Estrogen receptor 1 gene PvuII and XbaI polymorphisms were associated with unexplained recurrent spontaneous abortion in a Chinese Han population., PR frequently prevails over ER in pulmonary lymphangioleiomyomatosis, Our results indicate that a greater number of dinucleotide repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men., meta-analysis revealed that the G allele in the XbaI polymorphism of estrogen receptor alpha was associated with a statistically significant increase in the risk of prostate cancer, ERalpha intracellular concentration is an important target through which endocrine disruptors hamper the hormonal milieu of E2 target cells driving cells to different outcomes or mimicking E2., Data indicate that irect estrogen receptor alpha (ERalpha) methylation by histone methyltransferase SMYD2 regulates estrogen signaling., A meta-analysis suggests that the ESR1 PvuII polymorphism has an important role in coronary artery disease susceptibility., the results implicate the XbaI and PvuII polymorphisms of the ESR1 gene as possible disease-modifying factors in dermatomyositis in relation to the clinical manifestations., Data suggest that expression of ESR1 in omental adipose tissue (collected at term Cesarean section) is down-regulated in subjects with gestational diabetes mellitus; expression of MIRN222 is up-regulated in these tissue samples., In response to the elevated levels of Estrogen, the ERa signaling was accentuated in the ovarian epithelial cells of ERalphad/d mice, triggering increased ERa-dependent gene expression, abnormal cell proliferation, and tumorigenesis, ERalphaA87 mutation reduces the transactivation efficiency of ERalpha on an ERE reporter gene., ER-alpha-related bioinformatic data was integrated at different levels to systematically explore the mechanistic and therapeutic implications of ER-alpha., The associations between LKB1 expression and the methylated form of ERalpha (metERalpha), Src and PI3K, have been analyzed both in cultured cells and in 154 primary breast tumor samples., Data indicate that Fe65 is a positive estrogen receptor alpha (ERalpha) transcriptional regulator., unliganded ERalpha participates, together with other factors, in the maintenance of the luminal-specific cistrome in breast cancer cells., Polymorphisms in the ESR1 gene may have differential roles in the predisposition to male infertility according to the different ethnic backgrounds., CONCLUSION, estrogen receptor expression was positively correlated with lymphovascular space invasion in high-grade serous ovarian carcinoma. This study emphasizes the importance of estrogen pathway in promoting lymphatic or vascular spread of ovarian neoplasms., Results indicate a combination of decreased expression of ERs, AR and SRC-3 but not SRC-1 may be involved in the tumorigenesis of gliomas, ERalpha/SRC-3 axis may play central role in the regulation these tumors., The ratio of ER-alpha and PR-A expression in the epithelial glands and the stroma of endometrioid carcinoma biopsies may serve as an additional parameter in the histological evaluation., ERalpha and ERbeta genetic variants were associated with ovarian response to standard gonadotropin stimulation of women undergoing in-vitro fertilization affecting mainly the follicular growth., ESR1 intramolecular interactions in agonist and antagonist conformations have been elucidated., ESR1 polymorphisms affect age of onset of AD in women, and risk alleles vary by ethnicity., TTP acts as a bona fide ERalpha corepressor and suggest that this protein may be a contributing factor in the development of E2-dependent tumors in breast cancer., PRMT6 specifically interacts with ERalpha at its ligand-binding domain., We conclude that ER expression can be understood as a Darwinian process and linked to variations in estrogen delivery by temporal and spatial heterogeneity in blood flow, ESR1 amplification is not a key genetic abnormality in the tumorigenesis of breast cancer in Taiwan., This may have profound implications for the anti-estrogen treatment of ER-positive breast cancers that have increased levels of EGFR., Estrogen receptor expression and vessel density in the vagina wall in postmenopausal women with prolapse., ESR1 gene is considerably associated with knee Osteoarthritis etiology in the Chinese Han population., ESR1 genetic polymorphisms may contribute to the development of cerebral infarction, especially in the female population. [Meta-analysis], Both OPG and progesterone receptor are independently associated with good prognosis in ER positive breast cancer., Our data strongly demonstrated that ER1 was able to increase drug resistance of breast cancer cells through activating MDR1 transcription., E2 promoted the binding of ERalpha to the EREs (estrogen-response elements) of CLOCK promoter, thereby up-regulating the transcription of CLOCK, methylation of promoter sites of ESR1 and PGR is a relatively uncommon event in ductal and lobular breast cancer, the determination of epigenetic states of ESR1 and PGR could represent an alternative or complement to histopathological expression analysis, Insulin-induced apoptotic commitment depended on the down-regulation of Erk-1, insulin growth factor-1 receptor (IGF-1R), and fibroblast growth factor receptor-1 (FGFR-1)-mediated signaling., The ESR1 rs9340799 genotype may modify the ischemic arterial disease risk related to high endogenous estrogens levels in older postmenopausal women., Association of ESR1 gene polymorphism with preterm rupture of fetal membranes., Oral squamous cell carcinoma cells expressed functional ERa whose Ser118 phosphorylation and transcriptional activity were enhanced by FAK/AKT signaling, leading to promoted cell growth, MiR-4728-3p regulates expression of estrogen receptor alpha., The x allele of rs9340799 might have a protective effect on the risk of Alzheimer disease (AD) in Asia and in patients with sporadic AD (SAD). In addition, the p allele of rs2234693 might decrease the risk of patients with SAD. [Meta-Analysis], strong associations between ERalpha/ERbeta methylation and ER, PR, and HER2 status, tumor size, clinical stage, and triple negative tumors., there is an independent positive association between burden comorbidity and breast cancer with estrogen receptor expression, The loss of both hormone receptors in carcinoma cells and loss of PGR in the myometrium was a predictor of a more aggressive type of endometrial cancer and a poor prognosis., the PvuII variant was negatively associated with Alzheimer disease in the Caucasian population, ESR1 rs9340799 polymorphism was associated with prostate cancer risk in overall populations, Data indicate that estrogen receptors alpha (ERalpha) promoter unmethylation occurred more frequently in systemic lupus erythematosus (SLE) and rheumatoid arthritis(RA) than in controls., MCP-1 was shown to have a role in activation of the ER1 by phosphorylating Ser167 via the PI3K/Akt/mTORC1 signaling pathway, estrogen-activated ERa may mediate stimulatory effects on papillary thyroid cancergrowth and progression whereas ERb1 has some inhibitory actions, Aminoflavone mediates growth inhibition effects in ERalpha-positive and negative breast cancer cells., In low-grade ovarian carcinoma and in ovarian tumors of low malignant potential, methylation of the ESR1 promoter inversely correlated with survival (p = 0.031)., The ERS1 P allele is a novel sporadic breast cancer biomarker whereas p and x alleles enhanced chemotherapy responsiveness., ERalpha36 had a high expression mainly in adenocarcinoma and the high expression of ERalpha36 was strongly correlated with more advanced regional lymph node metastasis and poor survival in lung adenocarcinoma, TRPS1 gene expressionis associated with different epithelial mesenchymal transformation markers in ERalpha-positive and ERalpha-negative breast cancers., Data suggest expression of ESR1 (but not ESR2) in endometrium in women with endometriosis may be biomarker for subsequent fertility; ESR1 levels in normal range or down-regulated are indicative of fertility following medical or surgical treatment., Nongenomic activities of ESR1 are unable to mediate proliferative changes or the transcriptional profile following estradiol exposure., Med25 is identified as a new coactivator of ERalpha that is required for ERalpha-mediated regulation of CYP2C9 expression, ERalpha Xbal and ERalpha PvuII polymorphisms are not obviously associated with risk of idiopathic scoliosis., ERalpha expression highly correlates with ZNF217 in lysates from breast tumors., SMRT enhances cell growth of estrogen receptor-alpha-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis., Mutations of p53 increase the stability of the protein, which in turn promotes the biogenesis of miR-18a and decrease the expression of ESR1., Oncotype DX RT-qPCR assay for ER and PR correlation with IHC, Provide additional prognostic information when evaluating clinical features of ER(+), HER2(-) early breast cancer., Estradiol regulates TNF-alpha expression and secretion in ERalpha-positive breast cancer cells., Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer., We conclude that the CC genotype of PvuII in ESR1 is associated with an increased risk of CHB, HBV-related LC and HCC in Guangxi Zhuang populations., Data suggest that estrogen receptor (ER) subtypes (ERalpha and ERbeta) might play different roles in the development of breast cancer., These results suggested that both CYP17A1 and ESR1 polymorphisms may modulate the effects of phthalate exposure on the development of leiomyoma., CCNB1 is a biomarker for the prognosis of ER+ breast cancer and monitoring of hormone therapy efficacy, estrogen receptor binding and p300 redistribution have a role in a squelching mechanism for estradiol-repressed genes, Therefore, we studied expression of ERalpha and ERbeta protein in the trigeminal mesencephalic nucleus of ten human brains (five female/five male)., Based on this meta-analysis, we conclude that the ESR1 PvuII polymorphism might be a risk factor in Alzheimer's disease in Caucasians., examined in isolation, rs9340799 polymorphism does not appear to be a likely susceptibility variant for adolescent idiopathic scoliosis predisposition. rs9340799 may be associated with adolescent idiopathic scoliosis severity, progression and treatment., ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease, ESR1-CCDC170 rearrangements are found in an aggressive subset of estrogen receptor-positive breast cancers, findings suggest that TSC may have therapeutic effects on ERalpha positive breast cancers and moreover that TSC may suppress breast epithelial cell proliferation by inhibiting the estrogen pathway, High expression of ER-alpha is associated with lymphatic metastasis and vaginal recurrence in cervical adenocarcinoma., expression and localization of estrogen receptor in human breast cancer and its clinical significance, Data from case-control genetic association studies suggest that SNPs in ERA/ESR1 (rs2234693C; rs9340799) and ERB (rs1256049GA; not rs4986938) are associated with male infertility. [META-ANALYSIS], Epigenetic marks in estrogen receptor alpha CpG island correlate with some reproductive risk factors in breast cancer., data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment, These results suggest that ERalpha genotype may influence the relationship between habitual exercise and bone density., Nuclear p-Ser(167) -ERalpha was significantly positively correlated with p-MAPK and p-S6K1, and with significantly shorter relapse-free survival in endometrioid endometrial cancer (EEC)., ERa variant ERa36 mediates antiestrogen resistance in ER-positive breast cancer stem/progenitor cells, The two compounds inhibited cell growth, reduced expression of total estrogen receptor alpha (ER), Ser118-phosphorylated ER, FOXA1 and AIB1 and resensitized tamoxifenresistant cells to tamoxifen, Androgen receptor collaborates with estrogen receptor alpha to promote resistance to aromatase inhibitors in breast cancer cells., There was a higher number of pxpx and pxPX genotypes in the DJD+ samples compared to the DJD- group, which suggests the presence of polymorphism possibly modulates the ER-alpha activity in bone and contributes to the degenerative process in the TMJ., ESR1 and maternal sensitivity are both associated with age of menarche., SERPINA6-rs1998056 regulated by FOXA/ERalpha might be associated with female HCC risk, The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations, In the coronary intima from surgically repaired congenital heart disease patients there was a reduction in ESRA expression., Elevated expression of the ER-alpha36-EGFR/HER2 loops is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen therapy., ESR1 is strongly expressed in rectosigmoid endometriosis tissue., The potential utility of serum DNA methylation of ERalpha gene promoter., In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels., This review focuses on the new advances made in understanding the complex and important interface between ERRalpha and mitochondrial physiology. [review], Single-nucleotide polymorphism in the ESR1 gene is associated with racial differences in breast cancer., SGC7901 cells with high levels of ER-a36 expression exhibited estrogen hypersensitivity, high growth rate and high levels of Cyclin D1 expression while SGC7901 cells with knocked-down levels of ER-a36 expression were insensitive to estrogen stimulation, ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers, At clinically effective concentrations, phenytoin is a strong ERalpha cell antagonist but a many-fold weaker agonist, via interactions with helix 12., Data show that estrogen, acting via estrogen receptor alpha (ERalpha), induces rapid anticipatory activation of the unfolded protein response (UPR)., The ERalpha mRNA levels in tumor tissue were upregulated., GPR30 activation inhibits proliferation of estrogen receptor-negative breast cancer cells., ERalpha plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt pathway., mRNA expression profile of runx2 mirrored that of ERalpha36 and showed a degree subcellular co-localisation with ERalpha36. This study suggests that ERalpha36 is involved in the process of osteogenesis in BMSCs, In colorectal carcinoma, pERalpha(Ser167) score was a significant prognostic factor for both disease-free interval and overall survival, independent of sex, age, glucose levels, tumor stage, bowel obstruction/perforation, or adjuvant chemotherapy., miRNA mediated alterations in mTOR and ERalpha signaling establishes a new mechanism for altered estrogen responses independent of growth factor stimulation., The association between body mass index (BMI) and the risk of developing breast cancer according to the menstruation status and age, and the correlation between BMI and expression of estrogen receptor, was examined., Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex., Data indicate that serine/threonine-protein kinase D1 (PKD1) stimulates estrogen receptor alpha (ERalpha) expression in breast cancer MCF-7 cells., Neuroglobin player role in estrogen receptor alpha-positive cancer cell viability., Study reports a signature of the functionally active estrogen-regulated enhancers, particularly the 1,333 most active ERalpha enhancers linked to target coding gene activation; signature of these MegaTrans enhancers is the selective recruitment in trans of an apparent complex of other transcription factors, including RARalpha/gamma, GATA3, AP2gamma, STAT1, AP1, and FoxA1., Data show that recruitment of MLL1 (mixed lineage leukaemia histone methylase 1) to the homeobox-containing gene HOXA10 EREs (estrogen response elements) is mediated via ERalpha (estrogen receptor alpha)., Data show that estrogen receptor 1 (ESR1) rs2881766 polymorphism increased breast cancer risk and rs3798377 decreased the risk in Korean women., The ESR1 rs9340799 polymorphism might be associated with the risk of osteoarthritis. [Meta-analysis], This study contributes to elucidating the intrinsic relations among breast cancer subgroups defined by ER, PR and HER2 expression via integrating mRNA and miRNA expression, role in TLR7 signaling in plasmacytoid dendritic cells, Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER) and (AR) regulates the activity of androgen receptor (AR) to promote the growth of breast cancer and prostate cancer., Immunohistochemical profile of breast cancer with respect to estrogen receptor and HER2 status., Data suggest that rs2046210 SNPs located in the region of C6ORF97 (CCDC170)-estrogen receptor alpha (ESR1) might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients., upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts., Circulating tumor cells expression of ER, BCL-2, HER2, and Ki67 can be reproducibly measured with high analytical validity using the CellSearch System., ERalpha is overexpressed in a significant number of prostate cancer cohorts., a polymorphic variant of A-351G gene ESR1 estrogen can be considered as a marker of premenstrual syndrome. Pathological variant GG genotype was significantly associated with the presence of edematous and severe forms of the disease, Our investigation identified miR-219-5p as a negative regulator of papillary thyroid carcinoma development through targeting of ERalpha., ESR1 gene PvuII polymorphism is significantly associated with an increased risk of premature ovarian failure.ESR1 gene XbaI polymorphism is significantly association with risk of premature ovarian failure in Asian population., Data shows that lobular breast neoplasm expresses high levels of both ESR1 and ESR2. No tumor infiltrating leucocytes express ESR1. [review], No significant differences in ESR1-397C>T and -351A>G polymorphisms were was found between the patients with premature ovarian failure and controls, ESR1 single nucleotide polymorphisms and haplotypes influence the risk of hypospadias in white and Hispanic subjects, Study show that miR-221 is upregulated in HBV-related hepatocellular carcinoma (HCC) and modulates cell proliferation by suppressing ERalpha, functioning as a tumor promoter., REGgamma expression is positively correlated with ERalpha status and poor clinical prognosis in ERalpha positive breast cancer patients, Data indicate that the mRNA level for forkhead box P1 (FOXP1) and estrogen receptor beta (ERbeta) in ovarian carcinoma tissues decreased, while the expression level of estrogen receptor alpha (ERalpha) mRNA increased., after administration of abexinostat for three consecutive days, we did not observe any induction of ESR1 or ESR1-related genes and ERalpha protein expression, ERRalpha is needed for the efficient production of cytomegalovirus progeny, and we propose that the nuclear receptor contributes importantly to the induction of a metabolic environment that supports optimal cytomegalovirus replication., Data indicate that carnosol could significantly increase estrogen receptors ERalpha and ERbeta expressions of T47D cells, and remarkably increase ERalpha/ERbeta ratio., low ERb1 expression and high ERb2 expression are markers for identification of AET-treated ERa-positive breast carcinoma patients at risk of early and late relapse, respectively., ESR1/2 gene polymorphisms are associated with the results of controlled ovarian hyperstimulation., Mir-873 inhibits ESR1 activity and cell growth via targeting CDK3., ERalpha regulates chromosome alignment and spindle dynamics by stabilizing microtubules during mitosis., Our data indicates that cohesin is not a universal facilitator of estrogen receptor alpha-induced transcription and can even restrict enhancer-promoter communication., Data suggest that, in vaginal agenesis following modified Abbe-McIndoe neovaginoplasty using regenerated oxidised cellulose, expression of ESR1 is low in neovaginal tissue resulting in local hypo-estrogenism and thus vaginal trophism (vaginal atrophy)., High ESR1 expression is associated with lymph node metastasis and recurrence in Thyroid cancer., roles of ESR1-mediated transactivation and transrepression in the regulation of invasiveness of ESR1+/HER2+ breast cancer cells by E2, ERalpha contributes to the growth of papillary thyroid carcinoma (PTC) by enhancing an important prosurvival catabolic process, autophagy, in PTC cells., This study investigetes the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors., Data identified phosphorylation sites in ESR1 that direct its temporal recruitment to specific genes. Disruption of some of them in breast cancer cells elicit unique gene expression related to cell proliferation, morphology and migration. [review], ESR1 mRNA expression was significantly lower on granulosa cells of PCOS patients compared to controls., The identification of cytoplasmic proteins interacting with estrogen receptor alpha in breast cancer cells, No association between the ESR1 gene polymorphisms and the presence of PCOS was observed., None of the four polymorphisms studied in ESR1 and ESR2 were associated with increased risk for cataract., Combined expression of estrogen receptor 1 and VEGF-A is a potential prognostic marker for gallbladder carcinoma patients., our results suggest that ERalpha and ERRalpha cooperate to promote endocrine resistance, and they provide a rationale for the exploration of ERRalpha as a candidate drug target to treat endocrine-resistant breast cancer, Study shows the ability of Slug to bind E-boxes of ERalpha promoter region, and thereby to suppress de novo ERalpha synthesis contributing to tumor progression in breast and prostate neoplasm and drug resistance as well., Report substituted benzopyran targeting refractory prostate cancer cells behaving as ESR1 antagonist/ESR2 agonist., these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells., Has no impact on the prognosis of patients with ER-negative tumors., c-MYC expression is up-regulated through the cross-talk between ER and HER2 in aromatase inhibitor resistant breast cancer cells., It is shown that there is a connection between the PvuII-gene polymorphism EsRalpha with the degree of proliferation (chi2=43,142; p<0,0001) and the expression level EsRalpha (chi2=51,041; p<0,0001) in breast tissue at BBD in patients, estrogen receptor activation under chronic hyperinsulinemic condition increases breast cancer growth through the modulation of cell cycle and apoptotic factors and nutrient metabolism., At the molecular level, estrogen upregulated hepatic SHP expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP deficiency., ER-alpha, SRC-3, and p300 form an active protein complex on estrogen response element-DNA., Data show that loss of ERalpha in breast cancer cells results in a potent epithelial to mesenchymal transition characterized by changes in the expression profile of matrix effectors suggesting their potential role in breast cancer endocrine resistance., ESR1 gene PvuII polymorphism may not be associated with fracture risk in postmenopausal women [meta-analysis], ER positivity was increased in BRCA2 breast cancers compared to non-BRCA familial and BRCA1 breast cancers., FOXK2 might act as a negative regulator of ERalpha, and its association with both ERalpha and BRCA1/BARD1 could lead to the down-regulation of ERalpha transcriptional activity, effectively regulating the function of ERalpha., TNFalpha signaling causes redistribution of NF-kappaB and FoxA1 binding sites across the genome, creates latent ERalpha binding sites that underlie altered patterns of gene expression and clinically relevant cellular responses., Our study revealed novel molecular mechanisms underlying the regulation of ERa protein and provided insights in understanding the relationship between SPOP mutations and the development of endometrial cancer., These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation., Review/Meta-analysis, H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription, S6K1, overexpressed in many breast cancers, controls HDAC1-dependent transcriptional regulation of ESR1 levels upon mitogenic stimuli., HER2 status was highly concordant between the paired primary and brain tumors, whereas changes of ER and PR status occurred in a substantial proportion of the patients, MEL-18 loss in luminal breast cancer cells resulted in the downregulation of expression and activity of ER-alpha and the progesterone receptor, MEL-18 overexpression restored ER-alpha expression in triple-negative breast cancer cells., cells. These results suggest that adipocytes can modify breast cancer cell ER gene expression through hypoxia and also can promote EMT processes in breast cancer cells, supporting an important role of obesity in aggressive breast cancer development., Data suggest that targeting therapy-resistant estrogen receptor alpha (ERalpha)-positive cancer cells by converting the unfolded protein response (UPR) from cytoprotective to cytotoxic may hold significant therapeutic promise., rs2077647 polymorphism may be a risk factor for prostate cancer, while rs3798577 polymorphism could be a promoting factor in combination with other polymorphisms in estrogen receptor alpha contributing to development of high-grade carcinomas., ERalpha XbaI AA polymorphism may intensify the beneficial effect of estradiol on the distribution of fatty tissue after menopause; XbaI GG and PuvII TC genotypes may intensify the beneficial effect of estradiol on HDL level., negative-ER ,negative-PR ,positive-p53 and higher Ki-67 expressions were related to a higher mtDNA copy ratio. In addition, advanced T-status (p=0.019) and negative-HER-2/neu expression (p=0.061) were associated with mtDNA D310 mutations, These results suggest that H19 is an estrogen-inducible gene and plays a key role in cell survival and in estrogen-induced cell proliferation in MCF-7 cells, indicating that H19 lncRNA may serve as a biomarker for breast cancer diagnosis and progression, Data suggest that ESR1 agonists (here endocrine disruptors 2,4-dihydroxybenzophenone or nonylphenol) alter gene expression, stimulate cell proliferation, and induce cell migration/metastasis in adenocarcinoma breast cancer cells (MCF-7 cells)., this study demonstrated that a celecoxib and luteolin combination treatment yielded synergistic effects in four different breast cancer cell lines and suppressed triple-negative (ER-negative and HER-2 negative) breast tumor growth in vivo, Suggest that OATP2B1 is involved in cell proliferation by increasing the amount of estrogen in ER1-positive breast cancer cells., we describe a TR-FRET assay that monitors the interaction of the estrogen receptor (ER) alpha ligand binding domain (labeled with a terbium chelate via a streptavidin-biotin interaction) with a sequence of coactivator protein SRC3, Many membrane trafficking proteins contribute to the regulation of ESR1 degradation, thus unraveling the contribution of endocytic proteins in estradiol, The anticancer activity of triptolide against MCF-7 cells is partially mediated by downregulation of the ERalpha-mediated signaling pathway., Pin1 has a role in allosteric regulation of ERalpha function, Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression., Among women with breast cancer, those who were highly obese, but not mildly obese, around breast cancer diagnosis were more likely to have breast tumors with greater expression of proliferation genes and lesser expression of ESR1, Review/Meta-analysis, This study suggested that interactions among impulsiveness, testosterone, sex hormone binding globulin and androgen receptor gene CAG repeat length, The present meta-analysis suggests that the rs2234693 polymorphism is associated with an increased knee osteoarthritis risk, Our findings shed new light on the mechanisms underlying the progression of ER(+) breast cancer and indicate the potential of novel therapies targeting CCL2 and CCL5 pathways., Prediction of breast cancer prognosis and treatment response was improved by combining AR and ER status, demonstrates that miR-135b regulates ERalpha, AR and HIF1AN protein levels through interaction with their 3'UTR regions, and proliferation in ERalpha-positive BCa and AR-positive PCa cells, Regardless of methodology, basal-like cases seldom expressed ER/ESR1 or PR/PGR and were associated with the lowest expression level of HER2/ERBB2 relative to other subtypes., Data shows that ERA36 is a novel ERA that is expressed in breast neoplasm and confers tamoxifen resistance. It is localized in the cytoplasm and plasma membrane and seems playing a role in breast cancer stem cells. [review], Estrogen deprivation induced a cluster of noncoding RNAs that defined a large chromatin domain containing the ESR1 locus., Intragenic methylation levels correlate with ESR1 expression in homogenous cell populations but not in heterogeneous tumor biopsies, highlighting the significant differences between the in vivo tumor microenvironment and individual homogenous cell types., ESR1 mutations in advanced, endocrine therapy-resistant breast cancers(Review), SNAI2/SLUG is prognostic of patients' outcome. The strong inverse correlation with ESR1 indicates a significant impact of estrogen receptor pathway regarding these malignant features., IL6 secreted by ovarian cancer cells may contribute to the refractoriness of these cells to tamoxifen via the crosstalk between ESR1 and IL6-mediated intracellular signal transduction cascades., The present results indicate that the estrogen-ERalpha-H19 signaling axis plays a role in regulating the proliferation and differentiation potentials of the normal luminal progenitor which may also be important in the development of ER(+) breast cancer tumors, miR-18a expression suppression led to a decrease in trophoblast cell invasion and an increase in trophoblast cell apoptosis, by inducing estrogen receptor - alpha expression., In localized colorectal cancer carriers, mRNA-based CD3Z/CD8 profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 expression., The loss of heterozygosity in the regulatory regions of ESRa, ESRb, and AR genes is an early genetic alteration in breast carcinoma and has possibly synergistic effects on tumor proliferation, histological aggressiveness and down-regulation of these genes in tumor samples., Our study suggests that ESR1 gene amplification is an early event in breast pathology and might be a helpful predictive marker to identify patients at high risk of developing breast cancer., SERD- or SSH-palbociclib combination has therapeutic potential in breast tumors resistant to endocrine therapies or those expressing ESR1 mutations, Digital PCR results showed mutations in ESR1 gene significantly associated with aromatase inhibitor resistant metastatic breast neoplasm., genetic association study in population of postmenopausal women in southern China, Conclude that not only ERalpha, but also basal activities of EGFR and Src kinase are essential for Cd-induced signal transduction and activation of MAPK/ERK pathway for breast cancer cell proliferation., This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer., Data suggest that differential transactivation of ESR1 and ESR2 is exhibited by the various isoflavone phytoestrogens present in soy versus red clover commercial dietary supplements available on the German market as capsules., ERalpha inhibits epithelial-mesenchymal transition and stemness through the downregulation of Bmi1 in breast cancer, Trp383 in hERalpha and Trp335 in hERbeta interact with the NR-box motif of the H12 helix., Data show that ESR1 promotes obesity and metabolic dysfunction in animal model; its tissue-specific actions control feeding, physical activity and insulin sensitivity. [review], The expression of ERalpha and ERbeta was inversely correlated with menopausal age. No significant association was observed between ERs or PR expression and benign or malignant endometrial pathology., ESR1 XbaI and PvuII polymorphisms are associated with precocious puberty susceptibility (meta-analysis)., Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors, results show that PHB2 binds to the ligand binding domain of ERalpha with a conformational change in the helix 12 of ERalpha, results indicate that estrogen signaling in cervical cancer has dramatic differences from ERalpha+ breast cancers, and imply that estrogen signaling increasingly proceeds indirectly through ERalpha in tumor-associated stromal fibroblasts, Results show that ESR1 and ERBB2 were found to modulate the most numbers of gene pairs in breast neoplasm and they share complex interplay between each other suggesting a role in breast cancer pathogenesis through gene regulation., By investigating the role of ERa in the ETS-1 activity regulation, we demonstrated that ERalpha may be a novel ETS-1 co-activator and thus a potential therapeutic target in human neuroblastoma treatment, the contribution of ESR1 mutations to the development of acquired resistance to endocrine therapy in breast cancer patients (Review), ERalpha36 expression is valuable for differential diagnosis of malignant renal tumors from benign ones., ERa-dependent expression of LRIG1 dampens ErbB3 signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 accumulation, enhanced ErbB3 signaling to cell survival pathways, PR functions as a molecular rheostat to control ERalpha chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions in breast cancer, This newly described ERa-mediated and estrogen response element (ERE)-independent non-canonical autophagy pathway, which involves the function of BAG3 and provides stress resistance in our model systems., 10.7% of this Pakistani breast cancer cohort were estrogen receptor positive only, though 51% were ER and PR positive., The ER-/PgR+ phenotype is associated with higher grade with HER2 overexpression/amplification and occurs more commonly in younger women., ESR1 polymorphisms, PvuII and XbaI and VDR polymorphisms (TaqI, ApaI) did not significantly influence fractional calcium absorption, HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha., condensin complexes exhibit an unexpected, dramatic estrogen-induced recruitment to estrogen receptor alpha (ER-alpha)-bound eRNA(+) active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-alpha via its DNA-binding domain, Our findings support the hypothesis that estrogen receptor polymorphisms influence risk for major depression., Tissue factor isoform and estrogen signaling share downstream targets in BrCa; the concomitant presence of asTF and estrogen signaling is required to promote BrCa cell proliferation., HOXB7 Is an ERalpha Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance, PARP regulates estradiol-mediated cell growth by controlling the ER/IGF-1R/PDZK1 axis., Functional roles of ESR1 mutations in breast cancer (review)., ESR1 directly interacts with TRAF3 and promotes K48-linked proteasomal degradation of TRAF3., Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER)-dependent manner., ESR2 rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of prostate cancer (PCa). However, there was no significant association between ESR1 rs2234693 and PCa risk., the morphological features and ER-alpha/PRA/p53 immunohistochemical expression of a sample of 45 endometrial endometrioid carcinoma metastases compared to matched primary tumors, were evaluated., TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells, ER-alpha status of endometrioid adenocarcinomas could restrict eventual proapoptotic or anti-apoptotic impact of aberrantly expressed Cx43 and Cx26 in these tumors., the conformational dynamics of ERalpha36 in the absence and presence of Hsp90 and gammaSyn, is reported., Nuclear ERalpha expression is an independent predictor of recurrence in pT1a lung adenocarcinomas and correlates with poor prognostic immune microenvironments., Data indicate that high proto-oncogene protein HER-2 (HER2) and low estrogen receptor alpha (ESR1) mRNA levels are required for achieving trastuzumab response., ESR1 gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations., the ESR1 PvuII polymorphism is associated with AD susceptibility in males, and that ESR1 XbaI polymorphism is associated with AD risk in the Japanese population. the PP/XX haplotype is associated with AD susceptibility in the Chinese population., The ESR1 ubiquitin binding surface contributes to the modulation of estradiol-induced ESR1-mediated cell proliferation., our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features., AMPK-alpha-2 binds to ER-alpha, as well as ER-beta., This study demonstrates that ER-alpha36-mediated rapid estrogen signaling is involved in the neuroprotection activity of estrogen against oxidative toxicity., Collectively, the results demonstrate a novel ligand-dependent action of ERalpha that stimulates the activity of an E3 ligase., Data suggest 17beta-estradiol stimulates odontoblastic differentiation of dental pulp via coordinated regulation of estrogen receptor alpha, c-Src, and MAP kinase signaling pathways, which may play key role in calcification/regeneration of dentin., In estradiol-treated monocytes, there is a direct physical interaction of ligand-activated estrogen receptor-alpha 36-kDa splice variant with NF-kB p65 component in the nucleus. This is not changed during differentiation into macrophages or dendritic cells., CORRELATION BETWEEN CLINICAL PATHOLOGY OF LUMINAL B BREAST CANCER AND DETERMINATION OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER2 EXPRESSION COMBINED WITH NUCLEAR MORPHOLOGY., Results show that genetic variants in the oestrogen receptor alpha and the oxytocin receptor may be associated with an increased risk of oesophageal adenocarcinoma and Barrett's oesophagus., APOBEC3B is required for regulation of gene expression by ERalpha and acts by causing C-to-U deamination at ERalpha binding regions., Uni- and multivariate analyses included age, tumor size, grade, ER, and Her2; in multivariate analysis, MammaPrint reached near-significance (HR 3.01; p 0.08)., Expression of seven ERalpha splice variants, total progesterone receptor (PR) and of five PR transcript isoforms was found to be significantly decreased in endometrial cancer, ddPCR technique could be a promising tool for the next-generation sequencing-free precise detection of ESR1 mutations in endocrine therapy resistant cases and may assist in determining the treatment strategy, ESR1 PvuII, XbaI, and P325P polymorphisms are associated with breast cancer susceptibility [meta-analysis], Results of the meta-analysis revealed a potential benefit of positive ESR1 mRNA expression in survival in patients with NSCLC, especially in those of advanced stage. No statistically significant association was found between ESR2 mRNA expression and NSCLC patients' prognosis., Our results thus demonstrated that ER-alpha36 is involved in neuroprotective activities mediated by both estrogen and tamoxifen., Inhibition of MTA1 by ERalpha contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis, Cells traditionally considered as being deprived of estrogen receptor are able to respond to hormonal stimulation via the ERalpha36 receptor. [Review], ERa mRNA and protein levels of in multiple leiomyomas were significantly lower than those of solitary leiomyomas, whereas ERb mRNA and protein levels in multiple leiomyomas were significantly higher than those in solitary leiomyomas., a G2014A SNP genotype in exon 8 of the estrogen receptor was associated with postmenopausal women who had osteoporotic hip fracture., For key genes ERBB2 and ESR1, we demonstrate that overexpression is linked to the production of highly modified and truncated splice variants in tumours, but not controls, correlated with tumour subtype, Our meta-analysis results strongly suggest that the ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) are not associated with CVD risk., Estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 samples with high-methylation risk score had the worst 5-year survival rate and overall survival time., ESR1 mutations can be robustly identified with circulating DNA analysis and predict for resistance to aromatase inhibitors therapy., Activation of ERalpha but not ERbeta increases ADAM9 expression in cultured human neuronal cells., findings define, for the first time to our knowledge, a direct regulatory pathway between ERalpha and HIF-1alpha, which might modulate hormone response in treatment, Our study offers evidence that the catechol-O-methyltransferase and estrogen receptor alpha genes may also play a role in the susceptibility to depressive mood in postmenopausal women., ESR1 may be associated with low mineral osseous densitometry, while CYP17 and COMT gene polymorphisms were not associated with mineral osseous densitometry., it is concluded that the ESR1 haplotypes may influence the Th2 cytokine profile and susceptibility to SLE among the South Indians, homozygote (XX) genotype of ER-alpha gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population., expressed in prolactinomas, especially among men and post-menopausal women, Protein kinase CK2 expression predicts relapse survival in ERalpha dependent breast cancer, and modulates ERalpha expression in vitro., Data show that Cyclin D1 has a higher expression in breast cancer, positively correlated with estrogen receptors (ER) and better prognosis., These findings expand our understanding of hormone responsiveness in the tumor microenvironment; however, additional in-depth studies are required to elucidate the detailed mechanisms of TSA-induced ERalpha regulation under hypoxia., ERalpha decreased CCL5 and IL-6 expression in conditioned media that was collected from Cancer associated fibroblast cell., the MapQuanttrade mark assay, based on mRNA expression assay, provides an objective and quantitative assessment of Estrogen receptor, Progesterone receptor and HER2 status in invasive breast cancer., Genetic variation at the WLS and CCDC170/ESR1 loci were found to be significantly associated with bone mineral density, Expression of ESR1, RMND1 and CCDC170 associated with variants in separate enhancer elements predisposing breast cancer. [meta-analysis], There was no difference in distribution of polymorphic genes ESR1 and VKORC1 in peptic ulcer hemorrhage patients of both sexes, with the exception of A/A VKORC1 genotype found in women., Along with the PHF20/MOF complex, G9a links the crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression., rapid signaling through ERalpha is essential for many of the transcriptional and physiological responses of ECs to E2, and that ERalpha rapid signaling in ECs, in vivo, may be critical for the vasculoprotective and anti-inflammatory effects of estrogen, Three SNPs of the ESR1 gene were not associated with increased BC risk., Enhanced KLF17 expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression., Among the proteins reported here, some well-known breast cancer markers (e.g., annexin A1, annexin A2 and vimentin) were identified in the MDA-MB-231 cell line and thus we were able to distinguish both cell lines sufficiently., ESR1 and VKORC1 single nucleotide polymorphisms were used to determine the vitamin K dosage in patients with ulcer-related hemorrhage.,
OFFICIAL_GENE_SYMBOL ESR1,
OMIM_DISEASE Breast cancer, Migraine, susceptibility to, Myocardial infarction, susceptibility to, Estrogen resistance, Atherosclerosis, susceptibility to, HDL response to hormone replacement, augmented,
SP_COMMENT domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain., function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., online information:Estrogen receptor entry, polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture., PTM:Glycosylated; contains N-acetylglucosamine, probably O-linked., PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity., similarity:Belongs to the nuclear hormone receptor family., similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily., similarity:Contains 1 nuclear receptor DNA-binding domain., subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.,