Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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erb-b2 receptor tyrosine kinase 2(ERBB2) erb-b2 receptor tyrosine kinase 2(ERBB2) Related Genes Homo sapiens
CHROMOSOME 17,
CYTOBAND 17q11.2-q12, 17q11.2-q12|17q21.1,
ENSEMBL_GENE_ID ENSG00000141736,
GENERIF_SUMMARY peptide library generation for HER2/neu ligand identification, HER-2 gene amplification and protein overexpression has been associated with increased risk of advanced-stage breast cancer and poor prognosis., Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo., overexpression not associated with in vitro drug resistance to CMF or FEC chemotherapy combinations in primary breast cancer, Expression and gene copy number analysis of ERBB2 oncogene in prostate cancer., Identification of a minimal c-erbB-2 promoter region that mediates preferential expression of a linked foreign gene in human breast cancer cells, NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer, HER-2-positive breast carcinomas as a particular subset with peculiar clinical behaviors., Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma, Automated electrorotation to reveal dielectric variations related to HER-2/neu overexpression in MCF-7 sublines, ErbB-2 demonstrates a strong tendency toward stable self-association of transmembrane domains identifiable as coexisting populations of peptides whose associations are thought to modulate signal transduction., lack of amplification in nasopharyngeal neoplasms, feasibility of fluorescence in situ hybridization analysis of HER-2/neu amplification in oral mucosa brushings and to compare the HER-2/neu status with the history and smoking and drinking habits of healthy subjects, Data suggest that amplification of Her-2/neu appears to be mainly involved in initiation of breast oncogenesis and that its role in progression of breast cancers is uncertain., Except in a certain subset of cases, aneusomy 17 probably is not a significant factor for HER-2/neu protein expression or for clinical assessment of HER-2/neu status., Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes, Increased c-erbB-2 expression contributes to the development of cholangiocarcinogenesis into an advanced stage associated with tumour metastasis., expression of cyclooxygenase 2 in HE-2 positive breast cancer, Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers, expression correlated with increased event-free and overall survival in high-grade osteosarcoma, ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas., p53 mutational pathway may favor selection for ErbB2 gene amplification during tumor progression in breast cancer, Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta, Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu are expressed in ovarian cancer., gene is essential in preventing dilated cardiomyopathy, overexpression seen in 16% of NSCLC tumors, most frequently in adenocarcinomas and large cell carcinomas, identification of a dimerization motif for ErbB homomeric association, ErbB2 activation of ESX gene expression, ErbB2 membrane RTK can confer resistance to taxol-induced apoptosis by directly phosphorylating Cdc2., HER-2/neu peptides can activate T cells in draining lymph nodes from women with invasive breast cancer., S-erbB-2 serum levels above 40 U/ml independently predicted unfavorable response to 2d-line hormone or chemotherapy in advanced metastatic breast cancer. 1st-line drugs may select for overexpression of erbB-2 genes and lesser response to 2d-line drugs., Expression of c-erbB-2 in node negative breast cancer does not correlate with estrogen receptor status, predictors of hormone responsiveness, or PCNA expression, Role of the N-terminus of epidermal growth factor in binding studied by phage display., Her-2/neu expression and gene amplification in gastrinomas is correlated with tumor biology, growth, and aggressiveness., Overexpression of erbb2 increases expression of VEGF A, C and D in breast carcinoma, the expression of mitochondria-encoded COXII is HRG-responsive. The levels of ErbB2 expression are decisive for the diverse biological activities of HRG., ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines, The expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors, ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation; cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK., ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions., HER-2 tyrosine phosphorylation is a component of cytotoxic t-lymphocyte stimulation by tumor cells, ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the inhibitor geldanamycin (HSP90), uPA and its receptor are not upregulated by the circulating fraction of this proto-oncogene in advanced NSCLC, Data report the identification of signaling pathways required for suppression of integrin alpha2beta1 function by c-erbB2., Overexpression of c-erbB-2 was significantly associated with poor survival & can serve as a prognostic marker. C-erbB-2 is related with tumor progression in colorectal cancer which can be seen on protein level & reflects chromosomal gain at the 17q locus., Wound closure could be delayed up to 50% by antisense c-erbB2., ILC did not display ERBB2 overexpression . The observed discrepancy in the pattern of the human oncogenes CCND1 and ERBB2, which are involved in the process of carcinogenesis of ductal tumors., significant HER2 expression seen in high-grade, muscle-invasive urothelial carcinoma; but HER2 expression in context of paclitaxel-based chemotherapy associated with significantly reduced risk of death, Prognostic value of the quantitative measurement of the oncoprotein p185(Her-2/neu) in a group of patients with breast cancer and positive node involvement., HER2 expression is regulated by the interaction of DRIP130 and ESX, c-myc and c-erbB2 amplification in breast cancer, differential gene expression patterns in positive and negative breast cancer cell lines and tissues, High-level coexpression of ERBB2 and ERBB4 was significantly related to tumor proliferative activity in ependymoma, marked intratumoral heterogeneity of c-myc and cyclinD1 but not this gene in breast cancer, C-erb-2 overexpression is not statistically related to either proliferation or cancer specific death in upper urinary tract urothelial tumors., contribution of HER2 transcription factor binding site to ERBB2 overexpression, Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma., Kaplan-Meier curves showed a significantly worse disease-related survival (p = 0.034) in patients with HER2-overexpressing tumors compared to those without HER2 overexpression., Signaling by HER-2/neu has a critical role in the early stages of breast tumorigenesis., relationship between the mast cell density and the context of clinicopathological parameters and expression of p185, estrogen receptor, and proliferating cell nuclear antigen in gastric carcinoma, selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB2-mediated signaling and oncogenicity, may be activated in the early stage of pathogenesis of cervical carcinoma in geriatric patients, Computational exploration of conformation space of erbB2 homodimer transmembrane segments revealed 2 stable conformations, Overexpressed erbB-2 can cause EGF independent transformation of nonmalignant MCF-10A breast cells., Differential expression follows BCG immunotherapy in superficial papillary transitional cell carcinoma of the bladder, role of overexpression in lung cancer development in conjunction with erb-B-3 overexpression, identification of domain motifs required for geldanamycin-induced degradation, Transcriptional analysis reveals a molecular connection to fatty acid synthesis., up-regulates S100A4 and several other prometastatic genes in medulloblastoma, examination of amplification in breast cancer, reduced ER/PR expression may be one mechanism to explain the relative resistance of HER-2/neu-positive, Her-2/neu overexpression in patients with osteosarcoma is associated with an increased risk of lung metastasis, UROC28 mRNA expression was greater in breast cancers than in noncancerous tissues (p < 0.0001), as was ERBB2 mRNA., HER-2/neu overexpression does not adversely and may favorably influence response to adjuvant oophorectomy and tamoxifen treatment in patients with estrogen receptor-positive breast tumors, ErbB2 is a target of CHIP ubiquitin ligase activity; CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90, Tumors expressing this protein produced more in the affected breast than in the unaffected breast in unilateral breast cancer., results may suggest the contribution of c-erbB-1 molecule in progression of gastric carcinomas in southern Iranian patients, results demonstrate that tamoxifen resistant MCF-7 cell growth is mediated by the autocrine release and action of an epidermal growth factor receptor-specific ligand inducing preferential epidermal growth factor receptor/c-erbB2 dimerization, Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis., Expression of vascular endothelial growth factor in invasive ductal carcinoma of the breast and the relation to angiogenesis and p53 and HER-2/neu protein expression., Crystal structures of the entire extracellular regions of rat HER2 at 2.4 A and human HER2 complexed with the Herceptin antigen-binding fragment (Fab) at 2.5 A, model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors, Segregation of receptor and ligand regulates activation of epithelial growth factor receptor; following a mechanical injury, heregulin-alpha activates erbB2 in cells at the edge of the wound, and this process hastens restoration of epithelial integrity, erbB-2-mediated invasiveness is dependent on p38MAPK induces cell surface alpha4 integrin downregulation, Expression of c-erbB-2 occurs more often in breast cancer cases than in cervical cancer and shows a significant relationship with histologic grading of the tumor, in a study group of Indian women., EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization, T cells transduced with the same chimeric gene might be utilised in the treatment of patients with HER-2/neu(+) tumours., HER2 expression together with PgR negativity may serve as the counterpart of the proliferation marker in predicting the in vivo response to DXR., This gene is amplified in breast cancer., ERBB-2 signaling is regulated by a MUC4/sialomucin complex, Phosphatidylinositol 3'-kinase signals cell neoplastic transformation by erbb2., results demonstrated significant positive staining of c-erbB-2 in the salivary tumorigenic tissue but not in the surrounding non-tumorigenic tissue, pointing to a biological role in the tumorigenic process, Expression of epidermal growth factor receptor, erbB2, and erbB3, but not erbB4, was detected throughout the epidermis. Labeling for erbB2 and erbB3 accentuated in upper spinous layers, in MCF-7 breast cancer cell line, elevated MAPK activity results from enhanced ERBB2 expression in the estrogen deprived cells, MUC1 expression was inhibited by NGF treatment in breast cancer tumor cell lines, suggesting that its expression can be regulated by signals resulting from the homodimerization of Erb-B2., no evidence that the phosphorylation of TuM2-PK is initiated by the oncoprotein HER-2/neu in breast cancer patients, Levels of this protein in blood are positive predictors of the treatment of breast cancers with herceptin., Levels of this receptor in blood serve as a predictive marker for the clinical course of breast cancer., Data support that EGFR and HER-2/neu play an important role in cell cycle control in ductal carcinoma in situ., Aberrations of these genes is regulated in tumor microenvironments., ErbB2/ErbB3 dimer functions as an oncogenic unit to drive breast tumor cell proliferation., HER-2 expression and cell proliferation seem to provide prognostic information for node-negative breast cancer patients., overexpression of HER-2/neu gene could induce NF-kappaB activity in human breast cancer cells, The presence of increased levels of HER2/neu in synovial sarcoma is associated with a more favorable clinical course., her2/neu contributes to Wilms tumor angiogenesis in vivo by regulating VEGF, ERBB2 and ERBB3 expression is inhibited by quercetin, resulting in decreased autophosphorylation and cell growth, The review evaluates the status of serum-based testing for circulating HER-2/neu receptor protein and its ability to predict disease outcome and therapy response., expression of nm 23 and c-erbB-2 in primary tumor and metastases of colorectal adenocarcinoma showed that the incidence and expression of both protein markers in primary tumor tissue tended to increase after the appearance of liver metastases, ER81 is acetylated by two coactivators/acetyltransferases, p300 and p300- and CBP-associated factor (P/CAF) . Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116., different transcriptional and post-transcriptional mechanisms are responsible for the increased levels of erbB-2 transcript and protein in breast and non-breast cancer cells, our results suggest that estradiol treatment results in binding to membrane ER-alpha and interaction with a heterodimer containing ErbB2, leading to tyrosine phosphorylation., overexpression of HER2/neu is associated with the development of muscle-invasive transitional cell carcinoma of the bladder, A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer, High levels of serum HER-2/neu reflect aggressiveness of metastatic breast cancer, HER2 has a role in reducing apoptosis in breast cancer cells treated wtih 4-HPR, In cervical carcinogenesis, the overexpression of bcl-2 protein may be activated in the early stage of pathogenesis of cervical carcinoma. Expression of c-erbB2 was the signal of cell malignant change., role of urokinase plasminogen activator receptor (uPAR) and c-erbB-2 in breast and ovarian cancer, data suggest that HER-2 amplifications are frequently linked to alterations of the TOP2A gene in bladder cancer, value of this tumor marker regarding relapse, metastasis and death in resectable non-small cell lung cancer, a detailed characterization of the molecular events occurring at the ERBB2 amplicon in primary breast tumors, This study highlights a new pathway by which HER-2 may modify cancer behaviour., Immunization Her-2/neu peptides successfully induced humoral immune response with anti-tumor activity in an animal model of breast cancer., findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors, HER2/neu predominantly uses Akt to suppress RARE binding activity, which may be one mechanism by which HER2/neu induces ATRA resistance in breast cancer cells, HER2/neu disrupts cell-cycle regulation. (review), Overexpression of ErbB2 is associated with transitional cell carcinoma of the bladder, Her2/neu contributes to the growth of some Wilms' tumors, and an important mechanism of its action is promotion of angiogenesis., c-erbb-3 is overexpressed and amplified as a single and combined prognostic parameter in breast cancer., HER-2 protein expression can be a useful tool in differentiating a primary cutaneous appendageal neoplasm from HER-2 expressing metastatic breast carcinoma., HER-2/neu has no role in melanoma, HER-2/neu overexpression correlated with AKT activation (P=0.015)., HER2 signaling is negatively regulated by the PEST-type protein-tyrosine phosphatase BDP1, expression of c-erbB-2 protein may reflect biological behaviour of the tumour and may appear to be an important factor in development of colorectal cancer metastases, There is a clear-cut difference in Her-2/neu amplification between screen-detected and interval breast carcinomas., Study indicate that the coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer., immunohistochemistry in different thyroid cancers, In Paget's disease of breast, ERBB-2 protein overexpression is caused by amplification of the ERBB2 gene. ERBB-2 protein overexpression is caused by amplification of the ERBB2 gene., Strong membrane immunoreactivity is associated with high levels of HER-2 mRNA and gene amplification whereas cytoplasmic HER-2 is detected frequently and seems to be a marker of gastric tumor differentiation, ErbB2 receptor has a role in the inhibition of the IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells, EGFR and ErbB-2 have roles in ligand-dependent apoptosis that could be a natural mechanism to protect tissues from unrestricted proliferation, expression and prognostic significance of HER-2 in colorectal cancer and its relationship with clinicopathological parameters, research suggests that E6/E7 cooperates with ErbB-2 in head and neck carcinogenesis, at least in part, via the conversion of beta-catenin from a cell adhesion to a nuclear function, that is, to act as a potential transcriptional regulator, overexpression of ErbB2 enhanced NF-kappaB activation induced by ionizing radiation in human breast carcinoma MCF-7 cells transfected with ErbB2 genes (MCF-7/ErbB2), Overexpression of HER2 is associated with recurrent non-small cell lung cancer, regulation by hereulin through heterodimer formation with ErbB3, ErbB2 is a remarkably internalization-resistant receptor due to the firm association of ErbB2 with protrusions, A method validating ERBB2 gene expression in breast neoplasms has been developed., COX-2 up-regulates VEGF-C and promotes lymphangiogenesis in human lung adenocarcinoma via the EP(1)/Src/HER-2/Neu signaling pathway., HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes, C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis., Her-2/NEU oncogene is essential for the regulation of VEGF-C in ovarian carcinoma; p38 MAPK and NF-kappa B are critically involved in the transcriptional activation of the VEGF-C gene by Her-2/NEU., Shc is a critical angiogenic switch for VEGF production downstream from the HGF and ErbB2 RTKs., overexpression of ERBB2 is associated with gastric cancer, Chimeric immunoGrB molecule has therapeutic potential against HER2 tumors, especially in cases in which caspase-dependent apoptosis is inhibited., Monitoring ERBB2 blood levels represents a valuable tool for early prediction of the probability of response and progression-free survival to trastuzumab-based treatment of breast cancer., Association between HER-2/neu and VEGF expression supports the use of combination therapies directed against both HER-2/neu and VEGF for treatment of breast cancers., Cell surface expression of Her-2 is associated with osteosarcoma pathogenesis, overexpression of HER2 in nontumorigenic mammary epithelial is permissive for the ability of TGF-beta to induce cell motility and Rac1 activity and HER2 and TGF-beta signaling cooperate in the induction of cellular events associated with tumor progression, the extracellular domain of Serum HER-2 has a role in progression of breast neoplasms, Predictive value of a polymorphism in HER-2 (Val655Ile) to determine the risk of developing prostate cancer in patients with benign prostatic hyperplasia, evaluation of gene amplification in a subset of colorectal tumors and normal colonic mucosa, transactivation occurs through an indirect interaction between erbB2 and prolactin or leptin receptors, HER2 signaling enhances 5'UTR-mediated translation of c-Myc mRNA., Data provide the distribution frequency of HER2 protein expression and gene amplification in invasive ductal and lobular breast cancer., Overexpression of HER-2 was observed in only a small fraction of colorectal carcinomas, but were frequently accompanied by gene amplification., Activation of a set of signalling molecules, including MAPK, phosphatidylinositol-3-OH kinase (PI(3)K) and Src, is required for Neu/ErbB2-dependent lamellipodia formation and for motility of breast carcinoma cells., estrogen receptor redistribution to the cytoplasm and its interaction with HER2 are important downstream effects of HER2 overexpression, p21Cip1/WAF1 and HER2/neu togehter have a role in progression of breast neoplasms, only a few cases with aberrant Her2/neu expression in melanoma, many of them being primary cutaneous lesions rather than recurrent or metastatic lesions, overexpression of HER-2/neu in pancreatic adenocarcinoma seems to be a result of increased transcription rather than gene amplification, Circulating tumor cells in breast camcer were used to measure HER-2 gene amplification as an indicator of cancer progession., Expression of HER2/neu is not a poor prognostic factor in low-grade osteosarcoma., Relation between expression, DNA ploidy and human papillomavirus infection in cervical carcinoma., ErbB-2 is an important component of the plexin-B receptor system., In pancreatic ductal adenocarcinoma, membrane HER-2 overexpression was more frequent in intraductal than in invasive components but the incidence of cytoplasmic HER-2 overexpression did not differ between intraductal & invasive components., HER-2-amplified breast cancers have increased amounts of angiogenesis, decreased amounts of hypoxia, and increased markers of fibrin degradation, c-erbB-2 and EGF-R are overexpressed in breast neoplasms and have an inverse association with Estrogen Receptor expression, Data suggest that HER2 may act as the key molecular sensor of energy imbalance after the perturbation of tumor-associated fatty acid synthase hyperactivity in cancer cells., The extracellular domain of HER-2/neu, the p105 fraction, which is found in the circulation, does not appear to have any regulatory influence on uPA in patients with cervical cancer., EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck, Significant correlation was observed between HER-2/neu overexpression and clinical outcome in germ-cell testicular tumors., In patients with breast cancer, most CNS metastatic tumor deposits showed expression for either EGFR or HER-2/neu, and less often for both., This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator., Genetic polymorphisms may affect the development of prostate cancer. The frequency of Val655 in HER-2 was significantly lower in Japanese prostate cancer patients., serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy, kinase domain mutations identified in human tumors, PEA3 represses the transcriptional activity of two fragments of the ErbB-2 promoter in a dose-dependent manner and decreases the endogenous ErbB-2 mRNA in pancreatic cancer cells., we show that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo., ErbB2 serves as a critical component that couples erbB receptor tyrosine kinase to the migration machinery of corneal epithelial cells., HER-2/neu overexpression may be linked with overall increased tumor viability and a significant increase in the population of viable hypoxic cells, which is not due to differences in tumor vascularization., Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2, HER2-mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2-mediated amplification of epidermal growth factor-induced ERK signaling, the alpha6beta4-erbB2 heterodimer is an important signaling complex for the formation of cohesive keratinocyte layers, HER2/neu has roles in neoplasm progression and therapy [review], c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent, Amplification of EGFR was found in 10.37% of cases. The analysis revealed a lack of correlation between amplification of the oncogenes and the tumor phenotype., ERBB2 interacts with genes involved in angiogenesis, The HER-2/neu, a proto-oncogene, was found in about 30% of human breast cancers, promoting cancer growth and making cancer cells resistant to chemo- and radio-therapy., Hyaluronan regulates ErbB2 activity and its interactions with other signaling factors in carcinoma cells., c-erb-B2 and Bcl-xl expression can be useful for the histopatologic diagnosis of Barrett exophagux and correct interpretation of dysplasia., c-erbB-2 oncoprotein expressed in membrane may have a role in progression of gastric cancer, HER2/neu +3 may have a role in progression of breast cancer, data suggest that alterations of the Her2 gene can occur in breast cancer, although not usually after primary or neoadjuvant chemotherapy, HER2/neu engages Akt to increase WT1 expression, regulating cell cycle progression and apoptosis in HER2/neu-overexpressing breast cancer cells., erbB receptor inactivation by unknown mechanisms results in altered splicing of bcl-x towards enhanced formation of proapoptotic Bcl-xS, thereby contributing to enhanced apoptotic susceptibility of failing human myocardium, Applicability of employing FOXO4 regulation as a therapeutic intervention in HER2-overexpressing cancers., resveratrol downregulates HER-2/neu expression and induces apoptosis in tumor cells, a splice variant of decay-accelerating factor is expressed in c-erbB-2-positive mammary carcinoma cells showing increased transendothelial invasiveness, HER-2 overexpression is highly correlated with the expression of the apoptosis-suppressing gene bcl-xL., Inhibition of HER2/HER3 signaling protects against pulmonary fibrosis and improves survival., HER-2/neu over-expression correlates with more advanced disease in Iranian colorectal neoplasm patients., X-ray irradiation could lead to overexpression of HER-2 receptors on breast tumor cells, PARP-1 is involved in expression of ERBB2 in concert with NF-kappaB, which might be associated with proliferation of rheumatoid arthritis synovial cells., c-MYC amplification is an early event in breast cancer progression, while ZNF217 and Her2/neu amplification may play a role in the later stage of tumor development, integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling, hyaluronan, phosphoinositide 3-kinase, and ErbB2 receptor kinase form a positive feedback loop that strongly amplifies multidrug resistance 1(MDR1) expression and regulates drug resistance in human breast carcinoma cells, low-level amplification of TIIalpha gene locus may be sporadic mechanism of increased TIIalpha protein expression in pediatric non-brainstem glioma, which can coincide with low-level amplification of Her-2/neu, Direct-double-differential PCR determines HER2 gene dosage and amplification in breast cancer., loss of RALT expression cooperates with ERBB2 gene amplification to drive full oncogenic signalling by the ErbB-2 receptor, Her-2/neu is overexpressed in 25-35% of all mammary carcinomas in humans, Single nucleotide polymorphism is associated wiwth cancer risk., Transcriptional activity of eztrogen receptor beta was altered in a manner similar to ERalpha by activation of ErbB2/ErbB3., Diets enriched with corn or fish reduced mammary tumorigenesis in Her-2 transgenic mice., YY1 cooperates with AP-2 to stimulate ERBB2 promoter activity through the AP-2 binding sites, antibody trapping of ErbB2 in the endoplasmic reticulum showed inactivation of ErbB2 tyrosine phosphorylation and reduced heterodimerization of ErbB2 and ErbB3 and an increase in EGFR expression and activation, topo2a and HER-2 status might have therapeutic and prognostic implications., In operable non-small lung cell cancers, there may be different relationship of this protein with paatient outcome., Glioma BK channels are a downstream target of erbB2/neuregulin signaling., Results suggest that the currently identified genetic polymorphisms of HER-2 are not associated with an increased risk of breast cancer in Korean women, whereas one haplotype does affect protein expression of the tumor and disease outcome., HER-2-expressing esophageal squamous cell carcinoma cells could be killed by trastuzumab-mediated antibody-dependent cellular cytotoxicity., The ErbB2 is imported into the nucleus through a nuclear localization signal (NLS)-mediated mechanism., findings suggest that HER-2/neu signaling may result, directly or indirectly, in enhanced activation of various metabolic, stress-responsive, antioxidative, and detoxification processes within the breast tumor microenvironment, Elevated cytosolic HER-2/neu levels (> or =1,400 NHU/mg protein) were associated with a high probability of both shortened relapse-free, and overall survival., unusual stability is main mechanism that raises levels of AP-2 proteins; defective ubiquitin-dependent proteasomal-degradation pathway is possibly prime cause that affects the HER-2/neu gene and culminates in breast cancer, We hypothesize that HER2 genotypes can be predictive biomarkers in ovarian cancer, contributing to a genetic individual profile of great interest in clinical oncology., Distal ERBB2 promoter fragment displays specific transcriptional and nuclear binding activities in ERBB2 overexpressing breast cancer cells., These results demonstrate that C-erb-B2 (HER2/neu) may play a role in the tumorigenesis of synovial sarcoma., Her-2 overexpression was seen in 24% of breast cancer affecting Jordanian females., Systemic therapy with scFv(FRP5)-ETA can be safely administered up to a maximum tolerated dose of 12.5 microg/kg in patients with ErbB2-expressing tumors, justifying further clinical development., The co-expression of wt rat neu/ErbB2 transgene and mouse ErbB3, with physical and functional interactions between these two species of RTK receptors, was demonstrated in mouse mammary tumors., HER-2/neu and p53 are likely to be involved in the regulation of COX-2 expression in invasive ductal carcinomas of the breast., The movement of Arg784 in HER-2 appears to result from the absence of an anchoring residue like Asp746 in EGFR, which has been changed to Gly778 in HER-2., Subset of synovial sardcomsa with Her-2 amplification has a better overall prognosis, Cell proliferation was increased when ErbB2 and ErbB3 were both overexpressed., Both p53 and c-erbB-2 proteins appear to be involved at an early stage of malignization of pleomorphic adenoma., The overexpression of HER-2/neu protein was found in recurrent superficial urothelial carcinoma., The positivity of c-erbB2 oncoprotein was correlated with the size of the breast tumor; the cancers which are not infiltrative ductal, knows as having a better prognostic, were c-erbB2 negative., the most notable changes consisted in the overexpression of ErbB2 by Schwann cells of nerves from Charcot-Marie-tooth disease type 1A patients, A novel mechanism of ErbB-2 nuclear localization that involves interaction with the transport receptor importin beta1, nuclear pore protein Nup358, and a host of players in endocytic internalization was reported., These results suggest that HRG might be a new member of the growth factor family involved in the COX-2-dependent ulcer repair process., IHC and FISH together showed HER-2 overexpression/gene amplification in 21% of breast invasive carcinomas., HER-2/neu induces the binding of Sp proteins and HDAC1 to the RECK promoter to inhibit RECK expression and to promote cell invasion, c-erbB-2 oncoprotein overexpression is related to the clinical course of papillary thyroid carcinoma., ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer, HER-2/neu overexpression or gene amplification does not correlate with histological tumour type, stage, grade or prognosis., Trophic maintenance of the mammary gland in pregnant bitransgenic mice provides the additional events required for tumor formation and maintains the population of cells that are targeted by ErbB2/Neu for transformation., Our observations suggest potential prognostic significance of p185(HER2) overexpression with PTEN loss in gastric adenocarcinoma patients. This opens up the possibility of considering p185(HER2)and PTEN as a therapeutic target in gastric cancer., HER-2 overexpression promotes the growth and malignancy of mammary epithelial cells, in part, by conferring resistance to the growth inhibitory effects of TGF-beta, These data show that erbB2 stimulation is required for maintaining epithelial differentiation., Data show that c-erbB-1 and c-erbB-2 are differentially regulated in cancers of the papilla of Vater and pancreas, suggesting that the two types of cancer are biologically different., ERBB2 gene showed an agreement in amplification and polysomy and the level of protein expression in gastric adenocarcinoma., p185 probably plays an important role during the carcinogenesis and progression process of laryngeal squamous cell carcinoma., HER-2/neu has a role in progression of a unique tumor type of breast carcinoma, Study provides some evidence of a prognostic effect of HER2-positive circulating tumor cel in stage I to III breast cancer., Infection of human dendritic cells with recombinant vaccinia virus produces human Her2/neu., Overexpression of HER-2 was associated with sentinel lymph node micro-metastasis in breast cancer patients, The Increased expression of erbB-2 was associated with increased levels of Ki-67 and MCM2 expression, and combined overexpression of these receptors was associated with the highest levels of proliferation, suggesting a synergistic effect., HER2 overexpression was the best single predictive marker, but combinations of HER3, HER2 markers provided additional predictive information., The ability of Muc4 to segregate ErbB2 and other ErbB receptors and to alter downstream signaling cascades in polarized epithelial cells suggests that it has a role in regulating ErbB2 in differentiated epithelia., Blocking HER-2 cleavage with selective ADAM inhibitors may represent a novel therapeutic approach for treating HER-2 overexpressing breast cancer patients., ADAM10 is a major determinant of HER2 shedding, the inhibition of which, may provide a novel therapeutic approach for treating a variety of breast cancers with active HER2 signaling., HER2 appears to lack a critical role in the progression from ductal carcinoma in situ and invasive ductal carcinoma and HER2 status is maintained in metastatic lesions., the incidence of HER-2/neu positivity in colorectal cancers; the relationship of the HER-2/neu expression and patients' survival, The Val allele was overrepresented in the subset of HER2-positive breast cancers and the Ile allele in serous ovarian cancer., Data suggest that acquired resistance to lapatinib is mediated by a switch in cell survival dependence from ErbB2 alone to codependence upon ER and ErbB2, rather than loss of ErbB2 expression or insensitivity of ErbB2 signaling to lapatinib., Subset of pancreatic ductal adenocarcinomas is characterized by HER2/neu gene amplification. (Her 2 protooncogene protein), HER3 and HER4 have been related to a poor prognosis in bladder cancer., The activation of HER-2/CXCR4/ Akt signaling pathway in primary breast tumors may contribute to the formation of bone metastases in breast cancer., Pathways up- or down-regulated in the presence of ERBB2 over-expression, including genes not previously implicated in breast cancer that could be considered as candidate markers for prognosis and therapy., p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer, Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3, HER-2 codon 655 SNP and/or c-erbB-2 overexpression may also be used as a poor prognostic indicator for gastric carcinomas., ErbB2 has few interaction partners; of them Shc is the most common., Several known receptor tyrosine kinases (RTKs) are upregulated in gastric cancer being prime targets of a tailored therapy., There was a significant relationship between the expression of HER-2/neu and clinical stages and lymph node metastasis in laryngeal squamous cell carcinoma., PEA3 expression is not correlated with HER-2/neu expression in breast cancer tumor tissues, cyclin E expression in breast cancer cells was associated with negative steroid receptor status, HER2 presence, higher tumor grade and higher proliferation index, stable silencing of Her2 gene expression with plasmid expressing shRNA may hold great promise as a novel therapy for Her2 expressing breast cancers alone or in combination with anthracycline chemotherapy, Observed consistent increases in persistence associated with HER2 overexpression indicate a prospective mechanism for invasiveness previously documented in HER2-overexpressing human breast tumors., PEA3 and c-Jun stimulate synergistically the HER2/neu gene transcription with p300, The kinase domain is necessary for the activity of HER2 CTFs and the presence of these HER2 fragments could account for the resistance to treatment with antibodies., HER2(neu/ErbB2) is an effector of an apical EGF receptor complex mispolarization and its inhibition should be considered a candidate for clinical therapy of polycystic kidney disease., The prevalence of ER, PR and HER2/neu positivity in breast cancer of Jordanian women is lower than that of the western populations and close to other populations such as the Chinese and the minor ethnic groups of Northern America (African Americans)., Data suggest that mutant HER2 containing a G776(YVMA) insertion activates cellular substrates more potently than wild-type HER2., HER-2/neu and p53 may have a role in chemoresistance in patients with non-small cell lung cancer, PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells, The purpose of this study was to evaluate amplification of HER2 genes as predictors of response to chemotherapy in advanced breast cancer. HER2 gene amplification in 38 (45%) of the primary tumours., HER-2/neu amplification may constitute an independent prognostic factor in gastric cancer patients, The lack of gene amplification and robust HER-2/neu protein expression in small cell lung carcinoma (SCLC) tumour cells does not suggest a prominent role for the HER-2/neu gene in SCLC tumour progression., Among the glassy cell carcinoma (GCC) cases, estrogen receptor (ER), progesterone receptor (PR) and Her2/neu were positive in 2 (18.1%), 1 (9.1%) and 5 (45.4%) cases, respectively., Intraductal trastuzumab treatment may be effective in the management of ductal carcinoma in situ of the breast with HER-2 overexpression., Combining endocrine therapy with EGF receptor/HER-2/neu inhibitors should be tested in clinical breast cancer., HER-2/neu overexpression was detected in 47.4% of colorectal cancer patients; tumors with HER-2/neu overexpression showed higher postoperative recurrence; HER-2/neu overexpression may constitute an independent prognostic factor in colorectal cancer, These results suggest a relevant role for STAT5 and Bcl-xL as apoptosis-regulatory proteins in the pathogenesis of lung cancer, and overexpression of both Neu and activated STAT3, could be related with the proliferation rate in lung carcinoma cells., The development and characterization of 4 PEGylated antibodies to p185HER-2 (HER-2) are reported., The in vitro selection of DARPins against human epidermal growth factor receptor 2 (Her2), an important target for cancer therapy and diagnosis is reported., Significantly higher serum HER2 level was associated with bone metastasis of prostate cancer patients, Akt activ correlates with HER2 overexpr or LOH at the PTEN gene locus while inversely correlating with PR expression. When LOH at the PTEN gene locus and HER2 overexpr occurred simultaneously, incidence of Akt activ and reduced PR expr was significant., The phosphorylation sites most strongly correlated with migration & proliferation were identified. HER2 Y1248 is correlated with cell migration., In HER2-overexpressing cells, TGF-beta, via PI3K, recruits actin & actinin to HER2, which then joins Vav2, Rac1, & Pak1 at lamellipodia, prolonging Rac1 activation, enhancing motility, survival & invasiveness, phosphorylating Bad, & uncoupling Bad/Bcl-2., HSP90 binding to ErbB2 participates in regulation of src kinase activity as well as kinase stability, HER2 overexpression and amplification were present in tumors of high grade., Expression of HER-2 and plasminogen activator, urokinase receptor in primary tumors predicted gene status in 100 and 92% of patients, respectively, The importance of this biomarker was validated in a longitudinal study comparing pre- and post-operative levels and was shown to revert to normal levels after breast csncer surgery., N-WASP plays a pivotal role in regulating hyaluronan-mediated CD44-ErbB2 interaction, beta-catenin signaling, and actin cytoskeleton functions that are required for tumor-specific behaviors and ovarian cancer progression, study shows that newly diagnosed HER-2-overexpressing breast cancer patients are at increased risk for brain metastases, Newly described mutations in ERBB2 may play a role in predicting response to epidermal growth factor receptor (EGFR)-targeted therapy in hepatoma., To offer prognostic information and to direct appropriate treatment it is important to provide accurate laboratory assessment of the status of HER2 in breast cancer.[REVIEW], HER2 has a role in development of breast carcinoma in patients treated for Hodgkin's lymphoma or other pediatric solid tumors with radiation during breast maturation, enhanced signaling from the HER2/neu-HER3 pathway has a role in growth of tumors treated with fulvestrant in the presence of physiologic estradiol, Transgenic mice develop mammary tumors overexpressing rat Erbb2. Immunization with human Erbb2 peptide vaccine prevented growth of these tumors. Recombinant mouse IL-12 enhanced vaccine efficacy., In women over age 50 or with known postmenopausal status with an operable breast cancer, there is an inverse association between BMI and HER-2 over-expression., In summary, results indicate that Heregulin beta-induced store-operated calcium channels were regulated by c-erbB2 level and dependent on activation of phospholipase C in human breast cancer cells., type of TP53 mutation, especially missense mutation, is a strong prognostic indicator for disease-free survival and disease-specific survival in node-negative breast cancer, particularly in combination with ERBB2 amplification, Amplicon size is associated with response to trastuzumab in metastatic breast cancer., The efficiency of anti-HER2 adjuvant therapy could be evaluated, in a clinical trial, by sequential detection of HER2-positive micrometastatic cells within the bone marrow, before and after treatment., ErbB2 and Muc4 bind in signet ring carcinoma cells, which was not seen in highly differentiated adenocarcinoma cell lines., Detection of HER2 mRNA-positive circulating tumor cells after chemotherapy was associated with reduced disease-free survival but not with overall survival., The results of this study suggest that some cases of primary breast carcinoma are heterogeneous in regard to HER2/neu gene amplification or protein overexpression, Findings suggest that the ERBB2 mutation is rare in Korean lung cancer patients., Her-2/neu protein overexpression by HER-2 gene amplification may occur in extrahepatic cholangiocarcinoma and constitute an independent prognostic factor in patients with lymph node metastases., The use of RNA expression profiles and RT-PCR to analyze HER2 in frozen or formalin-fixed breast cancer samples may be an alternate approach to immunohistochemistry in combination with fluorescence- and chromogenic in situ hybridization., Human cancers overexpressing HER-2 might benefit from trastuzumab therapy., Review of the molecular interconnection data argue for cooperation between HER2 and Fhit in breast carcinogenesis., Our results show that c-erbB-2 over-expression correlates with poor histological grade and negative ER/PR status, and predicts poor overall survival in Asian women with breast cancer., propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement, Breast tumors that express truncated HER2 are resistant to trastuzumab and may require alternative or additional anti-HER2-targeting strategies, The erbB2+ cluster of the intrinsic gene set predicts tumor response of breast cancer patients receiving neoadjuvant chemotherapy with docetaxel, doxorubicin and cyclophosphamide, HER-2/neu overexpression and amplification is associated with uterine serous papillary carcinoma, These findings point to the existence of an association of ERBB2 allelic variants at both loci with specific breast tumor phenotypes., 40 breast carcinomas from BRCA1 mutation carriers and 40 sporadic breast carcinomas were examined for HER-2 and TOP2A amplification status, Results describe a designed ankyrin repeat protein evolved to picomolar affinity to Her2., HER2 overexpression is associated with higher rate of pathologic complete response to preoperative paclitaxel/FAC chemotherapy., Treatment with gefitinib, trastuzumab and pertuzumab to block signals from all HER homo- and heterodimers inhibited growth of HER2-overexpressing xenografts statistically significantly better than single agents and dual combinations., Expression of c-erbB-2 and p53 has no prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent., progesterone receptor and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers, HER2 gene status remains highly conserved as breast cancers metastasise but discrepant results occur because of interpretational difficulties of HER2 amplification., No GBM demonstrates HER-2/neu protein by IHC or amplification of the HER-2/neu gene by FISH. The HER-2/neu oncogene does not seem to play a role in the pathogenesis of GBM, Brain-metastasizing breast cancer belongs predominantly to the basal type or Her-2/neu type., HER2 overexpression in HER2 2+ carcinomas is associated with neither an increase in gene transcription nor a deregulation in the ubiquitin-dependent pathways, but instead seems to be regulated by protein kinase Calpha (PKCalpha) activity., Overexpression of Her-2 is associated with Lymph node metastasis in bladder cancer, High C-erbB-2 expression is associated with recurrence in breast cancer, Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas, BAG-1 negativity in association with p53 and c-erbB2 positivity identified a subgroup of tongue cancer patients with an aggressive phenotype, HER-2 protein overexpression as evaluated by immunohistochemistry and HER-2 gene amplification assessed by FISH were found to be relatively common in intestinal-type gastric carcinomas, Borderline for HER-2 protein expression at immunohistochemical assay (2+) were assessed for HER-2 gene amplification by real-time PCR and by FISH. PCR might be proposed as a highly predictive positive test in HER-2 assessment., HER-2/neu status of the primary breast cancer is determined by immunohistochemistry and fluorescent in situ hybridization., The overexpression rate of c-erbB-2 was higher in recurrence group than in non-recurrence group of Dukes'A and B colorectal carcinoma., ErbB-2, via PYK2-MAP kinase, upregulates the adhesive ability of androgen receptor human prostate cancer cells., Study shows a significant association between HER2 expression and the type of glioblastoma (GBM), with influence on survival rate. GBM with low-HER2 expression are more likely to be secondary GBM, carrying a better prognosis than de novo GBM., study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking, Imbalance in c-Met expression between tumour and surrounding normal tissue is associated with aggressive ductal carcinoma in situ phenotype. c-Met and HGF/SF may contribute to tumour development by different means than those controlled by Her2/neu., Activated HER2 is dependent on the spatial relation to a malignant tumor., Levels of HER-2/neu extracellular domain were above the cut-off value in breast cancer patients., In the absence of EGF, p38MAPK-activated AKT is necessary for HER-2 overexpressing human breast cancer cells to survive and to form colonies in soft agar., Results determine the level of MMP-2, its natural inhibitor TIMP-2, their ratio and HER-2/neu as diagnostic and prognostic factors in breast cancer., The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression., C-terminal cleavage of ErbB2 releases the receptor from a retention mechanism and causes endocytosis and lysosomal degradation of ErbB2., Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib., HER-2 and Bax are related to poor prognosis of breast cancer, while Bcl-2 is related to good prognosis., the major mechanism of HER2-mediated induction of FASN and ACCalpha in the breast cancer cells used in this study is translational regulation primarily through the mTOR signaling pathway., We showed that the mean HER-2 amplification index in carcinomas determined as 2+ was significantly lower as compared to carcinomas defined as 3+ (p < 0.0001)., patients with HER2/neu-positive cancers benefit more from -based and taxane-based adjuvant chemotherapy than those with HER2/neu-negative cancers., no treatment interaction was found between HER2 status and tamoxifen in ER+ tumours., These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities., Abnormal gene copy number of HER2 is associated with breast tumor progression, analysis of EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases, Expression of C-erbB2 was significantly higher in nasal squamous cell carcinoma than that in nasal polyps., Ile655Val polymorphism of the ERBB2 gene do not alter its activity and may not be associated with increased breast cancer risk among Chinese women., Findings suggest a strong age-related selective growth advantage for breast tumour cells belonging to the ER+PR+HER-2+ subgroup., c-erbB-2 is highly correlated with differentiation grade and metastasis of the extrahepatic cholangiocarcinoma tumor, a difference between the two HER2 isoforms regarding their tumorogenic potential with an advantage for the Val/HER2 isoform. In breast cancer patients treated with trastuzumab, the Val allele may constitute a risk factor for cardiac toxicity., Wwox reduces ErbB2 protein expression in vitro and expression of Wwox protein inversely correlates with expression of ErbB2 protein in prostate cancer tissues., A statistically significant correlation between serum level concentration and tissue HER-2 status, was observed., polysomy of chromosome 17 does not affect the ERBB2 expression and topoisomerase IIalpha mRNA expression is not related to gene status, Data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy., disruption of ERBB2 signaling with the selective inhibitor AG825 severely inhibited hESC proliferation and promoted apoptosis., HER2 protein overexpression and/or gene amplification are rare in colorectal carcinomas., Epitope mapping and structural analysis of an anti-ErbB2 antibody A21, p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma, data demonstrate that the full-length ErbB2 was localized at the cytoplasmic membrane and ErbB2 intracellular domain localized in the nucleus predominantly, Measurement of CA 15-3 serum values in conjunction with sHER2 and CA 15-3 can increase sensitivity in metastasis detection., This results suggest that FISH testing should be considered for tumours with 50% HER2 positive stained cells and that polysomy 17 without amplification is not associated with poor prognostic features., Significant heterogeneity exists between Her-2/neu expression in the in situ component and invasive components of adenocarcinoma of the breast., It was observed that HER-2/neu expression was significantly associated with high grade ovarian tumours, however intensity of positivity did not correlate with the grade of tumour., HER2, is a member of the ErbB family of receptor tyrosine kinases, that plays a key role in the pathogenesis of breast cancer, and when overexpressed, can correlate with a particularly aggressive clinical phenotype., HER2 gene amplification is a complex event, HER-2/neu transcriptionally activates Jab1 expression to promote proliferation of breast cancer cells., Activation of HER-2/Neu phosphorylation is associated with increase in tyrosine phosphorylation of phosphoinositide-specific lipase C-gamma-1 and recruitment of PLC-gamma-1 to HER-2/Neu protein molecule, Association of the HER-2 genotype with clinicopathologic characteristics and HER-2 expression may indicate its possible implication on the more aggressive phenotype in breast cancer., TOP2A status cannot be predicted from the HER-2 status and evaluation of the TOP2A status only in patients with HER-2 overexpression may lead to missing cases with TOP2A deletion with possible resistance to therapy in breast neoplasms., HER-2/neu showed overexpression, caused by gain/amplification in 50%, and may be involved in progression of Fallopian tube carcinoma, HER2/neu protein is frequently overexpressed in SDC, and in contrast to previous reports, overexpression of the protein is associated in most cases with HER2/neu gene amplification., HER2 immunoreactivity might have a limited prognostic value for advanced urothelial carcinoma patients with adjuvant M-VEC chemotherapy., The expression of C-erb B-2 contributes to angiogenesis in nasopharygeal carcinoma., we have shown an increased expression of ErbB-2 vestibular schwannomas, evaluation of HER-2 status should be performed in neoplastic tissue from metastatic site, whenever possible., HER-2 amplification has a role in response to trastuzumab-based neoadjuvant therapy, cellular PTPN13 inhibits Her2 activity by dephosphorylating the signal domain of Her2 and plays a role in attenuating invasiveness and metastasis of Her2 overactive tumors., Expression of HER-2/neu oncogene has a direct relationship iwth the grade of bladder transitional cell carcinoma., Genistein at > or =1 microM inhibited HER2 protein expression, phosphorylation, and promoter activity through an estrogen receptor-independent mechanism. In the presence of ERalpha, genistein mimicked E2 and inhibited HER2 protein phosphorylation., early-stage HER2+ cancers associated with lymphocytic infiltration are a biologically distinct subtype with an improved natural history, downregulation of SKP2 was critical for FOXP3-mediated growth inhibition in breast cancer cells that do not overexpress ERBB2/HER2., a novel mechanism by which plexin-mediated signaling can be regulated and explains how Sema4D can exert different biological activities through the differential association of its receptor with ErbB-2 and Met., Cyclin G2 expression is modulated by HER2 signaling through multiple pathways including phosphoinositide 3-kinase, c-jun NH(2)-terminal kinase, and mTOR signaling., A tight interaction between HER-2 and EPIL gene expression in invasive breast cancer cells is probable., Overexpresion of Her-2 is associated with micrometastatic disease in men with prostate cancer, These findings reveal a new kinase regulatory mechanism in which the alphaC-beta4 loop functions as an intramolecular switch that controls ErbB2 activity., A small group of hormone receptor-negative breast tumors with poorer 5-year survival express HER2 and basal markers simultaneously., Explore QSAR of ErbB2 inhibitors., disruption of surface HSP90/HER-2 interaction leads to inhibition of heregulin-induced HER-2-HER-3 heterodimer formation, reduced HER-2 phosphorylation, and impaired downstream kinase signaling., Our results indicate that the Val carrier was associated with increased risks in patients with breast cancer in Taiwan. The association was more apparent in patients who were younger than or equal to 45 years of age., investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas, Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer cells to trastuzumab and epirubicin., EphA2 cooperates with ErbB2 to promote tumor progression in mice and may provide a novel therapeutic target for ErbB2-dependent tumors in humans., estrogen receptor-positive tumors with Akt-1 expression...with the presence of HER2-positive tumors with strong Notch-2 expression, support the role of Notch and Akt in breast cancer progression, PF00299804 is a highly effective inhibitor of both the wild-type ERBB2 and the gefitinib-resistant oncogenic ERBB2 mutation identified in lung cancer cells., HER-2 polymorphism, especially in a homozygous form might play some role in the etiology of breast fibroadenoma formation, Salivary duct carcinomas in this study show HER-2/neu overexpression on both the protein and gene levels in approximately 30% of cases., efficacy of molecular targeted therapy can be expected even for patients with metastatic lymph nodes as long as the primary tumors are positive for HER-2 expression., c-erbB-2 expression was significantly associated with lymph node metastasis., NRG1alpha-induced adhesion variation is blocked by erbB2, PI3K, and Akt inhibitors, but not by PLC, ROCK, MLCK, or MEK inhibitors, implicating the erbB2/PI3K/Akt1 signaling pathway in NRG1-stimulated, integrin-mediated cell adhesion, The expression rate of c-erbB-2 was higher in adenomas than adenocarcinomas., HER2 overexpression was found in only four cases (10.5%) of the studied primary tumors and in all cases the HER2 expression was retained in the paired metastases., RIG1 plays a role in IFN-gamma-mediated therapy by downregulating p185 and its downstream PI3K/Akt/mTOR/VEGF-signaling pathway, UVA enhances the expression of ErbB2 via cAMP- and protein kinase-dependent Transcription Factor AP2 alpha activation in keratinocytes, analysis of the structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 that may correspond to the receptor active state, Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer., those with an increase in both HER2 and pAkt expression had the worst disease free survival., nine strong possible ligands can be identified for binding by mycobacterium leprae, Results show that disease stage, tumor grade, SES, race/ethnicity, negative ER and PR status, rather than negative HER2 status, were risk factors for survival., There can be differences in radiosensitivity, which, if they also exist between patient breast cancer cells, are important to consider for both conventional radiotherapy and for HER2-targeted radionuclide therapy., increased HER2 copy numbers may have a role in breast cancer, Cell line genetic heterogeneity and/or multiple determinants modulate the role played by EGFR/HER2 in regulating cell proliferation., HER-2/neu may have roles in the agressive phenotype and high proliferation in endometrial carcinomas, Her-2, together with cyclooxygenase-1 (Cox-1), may be involved in the early stage of endometrial cancer development., All cases were wild-type for HER2. Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma., examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy, Data show that serum level of soluble HER2/neu in patients with tumors characterized by high expression of this protein was significantly higher than in patients with low expression of HER2/neu and in women with benign diseases of the mammary glands., This study highlights the role of both AP-2alpha and YY1 transcription factors in ERBB2 oncogene overexpression in breast tumors.High ERBB2 expression may result either from gene amplification or from increased transcription factor levels., In human uterine leiomyomas, ERBB2 were also overexpressed., Findings strongly demonstrate that retinoblastoma (RB) and cyclin-dependent kinase 2 (CDK2) on one side and cytokeratin 8 (CK8) and epidermal growth factor receptor 2 (HER2) on the other may affect the clinical course of the disease in 56% of patients., polymorphic alleles of HER2 and CCND1 may not play an important role as genetic markers for breast cancer risk, but presence of Val allele may be useful for tumor prognosis., HER-2 Ile655Val SNP does affect serum HER-2 levels and it can be regarded as a predictive biomarker for breast cancer. patients with poor prognosis., Her2 positive rate was 40%, Neoadjuvant therapy resulted in a significant decrease in mitotic count and an increase in the proportion of patients with HER2/neu overexpression., not a suitable marker that could play a primary role in the clinical-therapeutic management of squamous cell carcinoma of the tongue, We found a positive correlation between FOXM1 expression and HER2 status, pointing to a potential role of FOXM1 as a new drug target in HER2 resistant breast tumour, as FOXM1 inhibitors for cancer treatment were described recently., Suggest that endocytosis defect restricts the degradation of ErbB2, and that c-Cbl-catalysed mono-ubiquitination is not involved in the impairment in ligand-induced degradation of ErbB2., Macrophage inhibitory cytokine-1may participate in the malignant progression of certain human cancer cells that overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase., Here we show that epidermal growth factor (EGF) and heregulin induce CD44 shedding in JIMT-1, an ErbB2-overexpressing cell line resistant to trastuzumab, accompanied by internalization and intramembrane proteolysis of CD44 and enhanced cellular motility, The researchers found that estrogen receptors, progesterone receptors, and Her/2neu correlated with tumor grade and age of breast carcinoma diagnosis as in previous research., HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization are reported., Findings substantiate the notion that breast cancer progression is often associated with alterations of HER-2/neu expression., HER2/neu was overexpressed in human bronchial epithelial cells treated with anti-BPDE., Overexpression of ERBB-2 is associated with malignant than benign pheochromocytomas, restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability [review], Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells, HER2 and estrogen receptor alpha expression depends upon nuclear localization of Y-box binding protein-1 in human breast cancers, analysis of insulin-like growth factor I receptor and HER2 in breast cancer, Data presented here indicate that endogenous HER-2/neu-specific humoral and T-cell immunity is greater in patients with +3 protein overexpression in their tumors than in patients with lower levels of HER-2/neu expression, The androgen receptor signaling pathways may contribute to development of metastatic disease in prostate cancer., HER2 status was the only primary tumor characteristic that correlated with the presence of circulating tumor cells., First detailed genome-wide characterisation of HER2/TOP2A-amplified breast cancers. The 17q12 amplicon is complex and harbours multiple genes that may be associated with breast cancer development and progression, and potentially therapeutic targets., Lipid raft-disrupting agents inhibited raft-associated CXCL12/CXCR4 transactivation of the HER2 and cellular invasion in prostate cancer cells., Knowledge of molecular mechanisms involved in geldanamycin-induced down-regulation of ErbB2 is important for future design of cancer treatment., Down-regulation of NOTCH3 significantly suppressed proliferation and promoted apoptosis of the ErbB2-negative tumor cell lines. Down-regulation of NOTCH3 did not have a significant effect on the ErbB2-positive tumor cell lines., The protein product of the ERBB2 oncogene is overexpressed in 33.3% of small cell lung carcinomas and is associated with the presence of disseminated disease, These findings suggested a dynamic change in Her2/neu expression during the development of oral squamous cell carcinoma(OSCC)., PAR1-stimulated EGFR and ErbB2 transactivation leads to prolonged extracellular signal-regulated kinase-1 and -2 signaling and promotes breast carcinoma cell invasion., The interaction of human MUC4 with the receptor tyrosine kinase HER2 in pancreatic adenocarcinoma cells is showm by reciprocal coimmunoprecipitation and cocapping studies., More than 25% of HER2 overexpression identified by immunohistochemistry assays in this Hong Kong cohort could not be verified by confirmatory in-situ hybridisation assays., Hpa may up-regulate the expression of C-erbB-2 in invasive ductal breast carcinoma., findings suggest that MUC4 is up-regulated and interacts with erbB2 in human gallbladder carcinoma, and thereby support the potential implication of MUC4 in erbB2 activation., BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR and HER2, potently suppresses the kinase activity of wild-type and activated EGFR and HER2 mutants, Differential regulation of ErbB2 expression by cAMP-dependent protein kinase in tamoxifen-resistant breast cancer cells., HER2-dependent transcriptional upregulation and protein secretion of MMP-7 are mediated by activated STAT3., There was no strong association between HER-2/neu overexpression and gene amplification in invasive urothelial carcinomas, and polysomy 17 was higher in tumors showing HER-2/neu overexpression., ERBB2 coding sequence reveals an absence of activating mutations in ERBB2 amplified breast cancer, caspases activate a previously unrecognized proapoptotic function of HER-2 by releasing a Bad-like cell death effector, Her-2/neu has a negative prognostic role in breast cancer survival among a Chinese population, irrespective of whether FISH or CISH is used to detect amplification of the Her-2/neu gene, Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration., the infection rate of HPV16 E6 and the positive expression rate of c-erbB-2 were significantly higher in the BCs than in the normal tissues, ADAM15 catalyzes the cleavage of E-cadherin to generate a soluble fragment that in turn binds to and stimulates ErbB receptor signaling, the extracellular domain of HER2 (ECD/HER2) may have a role in progression of breast cancer, HER2 codon 655 polymorphism is associated with breast cancer., study investigated the internalization of erbB2 in SKBr3 and SKOv3 cells, both overexpressing erbB2; two different mechanisms, which are cell type dependent for the internalization of erbB2, are proposed, Patients with HER2 FISH-positive LA-NSCLC had a poorer outcome even when treated with cisplatin-based chemoradiotherapy., We conclude that although HER-2/Neu amplification is not the primary mechanism in the development of liver tumors, it might play a role in one of the steps of multistage carcinogenesis., Although a significant percentage (25%) of pancreatic cancers demonstrate amplification of the HER2 gene, there is no association of HER2 gene amplification or chromosome 17 hyperploidy with poorer survival., Compared to PAI-1 protein levels, Chalkley counts and MIB-1, HER2+ and mutations of TP53 were the strongest independent markers of poor prognosis irrespective of nodal statusin breast cancer., A possible mechanism of role for nuclear HER2 in breast cancer patients., ErbB-2 overexpression suppresses Notch-1 activity, which can be reversed by trastuzumab or erbb2 tyrosine kinase inhibitors., HER2 expression was found in 16 (18%) of patients with gastric cancer., Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors, HER-2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells., Overexpression of HER2 is encountered in approximately 20% of invasive breast cancers., A possible correlation between overexpression of p53, proliferating cell nuclear antigen (PCNA), and c-erbB-2, and the clinicopathologic features of laryngeal squamous cell carcinoma, was investigated., we propose that SNPid rs4252633 could be the most deleterious nsSNP for HER2 receptor, ErbB2 inhibition leads to a persistent phosphorylation of ERK1/2, which negatively regulates the downstream signaling and cell growth, ErbB2 is found at the cell surface of differentiating keratinocytes and in the cytoplasm of poorly differentiated tumor cells., HER-2(10(85))-specific human CTL recognized the HER-2/neu+ HLA-A2.1+ tumor cell line SKBR3.A2, HER2/neu was exclusively overexpressed in serous carcinomas of endometrial origin., This study shows superior survival in HER2+ group following whole brain radiotherapy for cerebral metastases of breast cancer as compared to HER2- group., CK19 signal was occasionally observed in the peripheral blood of normal controls, and the HER2 signal was frequently present in the peripheral blood of both normal controls and breast cancer patients., HER2-positive groups showed worse prognosis in stage III of breast cancer, but not in stage I or II, Review of HER2-positive breast cancer treatment strategies., effects of HER2 amplification on carcinogenesis, tumorigenesis and invasion may be due to its effects on normal and malignant mammary stem/progenitor cells., HST may act as a paracrine factor in the adult breast., ABCC3 is a mediator of taxane resistance in HER2-amplified breast cancer., HRG-beta-induced MMP-7 expression was regulated by HER2-mediated AP-1 activation in MCF-7 cells., HER-2 may not have any role in gastrointestinal stromal tumor pathogenesis, Datas show that transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab., Coamplification of HER2 and MYC occurs in a subset of patients with metastatic UCC., we emphasize the important short-term prognostic value of currently used immunohistochemical markers for ER, PR, and HER-2, inhibition of HER3 may be more clinically relevant than inhibition of EGFR in HER2-amplified breast cancer and adding pertuzumab to trastuzumab may augment therapeutic benefit by blocking HER2/HER3 signaling, The mRNA stability factor HuR was shown to support ERBB2 transcript integrity, bind and endogenously associate with a conserved U-rich element within the ERBB2 transcript 3' UTR, and colocalize with HDAC6., Overexpression of HER2 protein in cancer tissue might suggest an increased risk of dying from prostate cancer, EGFR and erbB2 are potential targets in treatment of Malignant peripheral nerve sheath tumors, Inhibition of tyrosine kinase activity of Her-2/neu by quercetin could indicate an lateration in the Her-2/neu structure which promotes CHIP recruitments and down-regulation of Her-2/neu, Results describe the engineering of a retargeted herpes simplex virus 1 recombinant capable of entering cells through human HER2., Systematic review with statistical analysis of immunohistochemistry and FISH studies of HER2 testing and selection of patients suitable for trastuzumab therapy, analysis of EGFR and HER2 expression in primary cervical cancers and corresponding lymph node metastases, Akt1 activation accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3, TOP2A deletion is associated with poor prognosis in ERBB2-amplified breast carcinomas., PTK6 is coamplified and coexpressed with ERBB2 in human breast cancers. ERBB2 interacts with PTK6 and increases its intrinsic kinase activity, I655V polymorphism of HER2 transmembrane domain-coding region at codon 655 is associated with breast cancer., WWP1 may promote cell proliferation and survival partially through suppressing RNF11-mediated ErbB2 and EGFR downregulation in human cancer cells., A selective allosteric inhibitor of Akt kinase was used to interrogate a panel of breast cancer cell lines characterized for genetic lesions that activate HER2 amplification., Findings suggest that aberrant c-erbB2 expression in cell clusters overlying focally disrupted breast myoepithelial cell layers may trigger or signify the emergence of biologically more aggressive cell clones., HER2/Neu synergized with ETV1 to upregulate the endogenous Rcl., DNA methylation of tumor suppressor genes is a frequent event in ovarian cancer, and in some cases is associated with Her-2/neu overexpression., Her-2/neu oncogene and nuclear roundness variance were shown to be significant in the prediction of progression-free survival in prostate cancer., Her-2/neu expression and %DNA index were significant prognosticators for progression, Patients with HER2 nonamplified and HER1 through HER3-negative tumors showed significantly increased relapse-free and overall survival rates when treated with epirubucin-CMF., combined 17-AAG and Trastuzumab treatment of ErbB2-overexpressing breast cancer cell lines leads to enhanced ubiquitinylation, downregulation from the cell surface and lysosomal degradation of ErbB2, PCR-free L-FISH method can be used to evaluate ERBB2 amplification in both breast cancer cell-containing (paraffin-embedded tissue) and cell-free (serum) samples, a trivalent bispecific antibody targets ErbB2 and CD16 in tumor cells, EGFRvIII with ErbB-2 enhances tumorigenesis, Protein kinase A-mediated gating of neuregulin-dependent ErbB2-ErbB3 activation has a role in the synergistic action of cAMP on Schwann cell proliferation, Grade 1 invasive ductal carcinoma have a higher incidence of lymph node metastasis and may have Her-2-neu overexpression compared to tubular carcinoma., EBNA1-NT may act as a repressor of the HER2/neu oncogene, This study suggests a pivotal role of PI3 K, MAPK and mTOR pathways, via tuberin, in post-transcriptional control of CXCR4, initiated through estrogen-stimulated crosstalk between ER and HER2., Erb-B2 mRNA levels were not grade- or histotype-related in patients with meningioma, in some infiltrating squamous cervical carcinoma there is a rupture of the ERBB2 receptor, These data support the cooperative function of Pyk2 and FAK in breast cancer progression and suggest that dual inhibition of FAK and Pyk2 is an efficient therapeutic approach for targeting invasive breast cancer., Results suggest that HER-2 codon 655 polymorphism is associated with progession of oral squamous cell carcinoma in Taiwanse patients., This study confirms that Ets-1 is a downstream effector of oncogenic HER2, associated with MMP-1., The frequency of allelic imbalance was significantly higher (P<0.005) in HER2 amplified (27%) compared to HER2 negative breast tumors (19%)., findings indicate that serum HER2/neu levels are clinically valuable in monitoring metastatic breast cancer and non-small cell lung cancer patients., Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer., CK7, bax, CCND1, and HER2 represent marker proteins and frequently amplified genes in carcinomas of the ampulla of Vater., ERBB3 receptors are apparently segregated from ERBB2 receptors in their resting state, and both ligand-activated ERBB3 and ERBB2 do not share the same microenvironment as inactive ERBB3, we have demonstrated an increase in ERBB2 receptor activation in incompletely resected preinvasive breast cancer, Increased serum HER-2 is associated with advanced breast cancer., Its expression is prognostic parameter in breast carcinomas., EGFR as well as HER2 are prognostic factors of worse clinical outcomes, in high-risk early breast cancer, These results suggest an oncogenic role for HER2/neu in anti-BPDE-induced carcinogenesis., Examine human epidermal growth factor receptor 2 overexpression as a prognostic factor in a large tissue microarray series of node-negative breast cancers., Results showed that median age, menarche age, childbearing age, number of children, menopause age, and body-mass indexes were similar in both HER-2 pos and neg groups. # of involved lymph nodes and HER-2 status found to be prog. factors for survival., study found ERBB2 mutations (6%) are prevalent among ovarian serous low malignant potential tumors, study showed in ovarian cancer cells LHR expression & activation upregulate ErbB-2 expression; data establish role for LH & LHR in regulation of ErbB-2 expression & suggest ErbB-2 upregulation alone is insufficient in producing aggressive phenotype, HER2 mRNA could be a valuable prognostic marker for the detection of circulating tumor cells in early breast cancer patients, erbB2 plays a role in cardiomyocyte survival, that p38 MAPK and Akt signaling pathways are crucial for the ErbB2-induced MMP-9 up-regulation, invasion and migration of MCF10A cells, HER2 affects glial-cell migration by modulating EGFR-HER2 signal transduction, and that this effect is mediated by N-cadherin., Ectopically overexpressed HER2 in medulloblastoma cell lines significantly increased sensitivity to gefitinib's antitumor effects in vivo, Overexpression of HER-2 oncoprotein is associated with gastric carcinoma., Results demonstrated that in ER+ breast cancer, the HER2 receptor is commonly activated, but its low prevalence in ER+ tumors does not render it a useful prognostic parameter in tamoxifen-treated patients., analysis of the effect of HER2 pre-mRNA alternative splicing on breast cancer cells, polymorphisms of the HER-2 gene are associated with an increased susceptibility to lung cancer in females, non-smokers and non-drinkers subgroups in the Korean population, These data highlight the role of PAR4 as a new important player in the control of colon tumors and underline the critical role of ErbB-2 transactivation., Her2 immunostaining >and SBR grade 3 were independent factors predicting HER2 amplification status irrespective to cutoff guidelines, stabilization and accumulation of HER2 is induced by lapatinib, which potentiates trastuzumab-dependent cell cytotoxicity, HER-2/neu, AR, and p53 are expressed in a subset of histologically and clinically benign pleomorphic adenomas. These markers cannot be used to reliably predict early carcinomatous transformation in pleomorphic adenoma., gene amplification correlates with protein overexpression in Chinese patients with gastric carcinoma; chromosome 17 polysomy is likely not to be the main cause, Pin1 is a novel regulator of erbB2 that modulates the ubiquitin-mediated degradation of erbB2., HER2 and Topo IIalpha overexpression could be predictors of the response to neoadjuvant chemotherapy in both the CEF and CMF arms., Results revealed significantly increased levels of HER-2 neu in both serum and bronco-alveolar lavage., Combination therapy with trastuzumab was not effective in the HER2 or luminal B group, HER-2 overexpression represent important alterations that are related to the molecular pathways underpinning colorectal carcinogenesis, A significant MHC class I-restricted cytotoxic T-lymphocyte killing was demonstrated against Her-2/neu-positive ovarian cancer cells., Gene amplification and protein expression of HER-2/neu is correlated in esophageal squamous cell carcinoma., The aim of the study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues., Our results cannot support the hypothesis of a transactivation of HER-2 and thus a possible therapeutic benefit of trastuzumab in HER-2 negative breast cancers., statistically significant association was found between ERBB2 amplification and worse survival in patients with expansive gastric carcinomas (P=0.011). We conclude that ERBB2 status may have clinical significance in subsets of gastric cancer patients, frequent methylation had a strong association with HER2 amplification in breast cancers and suggested that frequent methylation can be a determinant of various characteristics in a fraction of human breast cancers., ErbB2 signalling regulated focal adhesion turnover in invasive breast cancer cells., Patients with a HER2 positive tumor receiving trastuzumab more frequently develop brain metastases than patients with a HER2 negative tumor but have a more favorable prognosis., Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation., ER and PR showed inverse association with HER-2/neu while positive association was seen with lymph node metastases in breast carcinoma patients in Pakistan, namely the ability of mAb combinations to instigate ErbB-2 endocytosis, is demonstrated, Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1., The use of the small scaffold targeting Affibody provides better contrast in HER2 imaging than does the monoclonal antibody., Human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in breast cancer., Paients with HER2-overexpressing breast cancer treated with trastuzumab had a high incidence of brain metastasis., mutations in EGFR and copy number gains in EGFR and HER2 were independent factors related to gefitinib sensitivity, in descending order of importance, Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer., we conclude that there is currently insufficient evidence to support the use of serum HER-2 extracellular domain in the routine management of individual patients with breast cancer, we cannot recommend using serum HER2 extracellular domain levels to make trastuzumab or other treatment decisions for individual patients with advanced/metastatic breast cancer., Data show that an eukaryotic plasmid encoding HER2 (pcDNA6/v5-his-HER2) has been constructed and a cell line expressing HER2 stably has been prepared successfully., SHP2 promotes HER2-induced signaling and transformation at least in part by dephosphorylating a negative regulatory autophosphorylation site., Poor downregulation of ErbB2 receptors is not due to sequence variations in the Proto-Oncogene Proteins Cbl binding site of these receptors., The high level of HER-2 amplification in combination with the homogeneity of its expression in primary and metastatic tumors argues for a possible therapeutic utility of trastuzumab in HER-2-amplified gastric adenocarcinomas., Invasive micropapillary carcinoma more commonly showed immunoreactivity for MUC1, CA125, and Her2Neu compared to invasive urothelial carcinoma with retraction artifact, Although c-erbB-2 expression is important from a biological standpoint, multivariate analysis showed that it is not an independent prognostic indicator in breast carcinoma in the local population., It is proposed that the negative feedback loop linking ERBB2 and GATA4 plays a role in the transcriptional dysregulation of ERBB2 gene expression in breast cancer., no cases of sinonasal undifferentiated carcinoma were positive for HER2/neu, ErbB-1/-2 receptors are inhibited by lapatinib in bladder neoplasms, a new model for the airway epithelial damage response, in which the MUC4-ErbB2 complex is a key element in the sensor mechanism and phosphorylation of the receptors., HER-2 overexpression/amplification in Barrett's oesophagus has a role in transition from dysplasia to adenocarcinoma, Our results indicated that HER2 status is independent of a response to a taxanes/cisplatin combination and is also not a prognostic factor for survival., HER1 and 2 do not seem to have a role in endometriosis physiopathology., Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells is characterized by multiplex kinase activity profiling, Findings indicated that dqRT-PCR was more precise and reproducible than IHC to detect HER-2, while CISH was an alternative and useful procedure for investigating amplifications involving the HER-2 gene., Inhibition of both AR isoforms did not affect EGFR and ERBB2 transcript levels but decreased EGFR and increased ERBB2 protein levels. Proliferation of 22Rv1 cells in SDM was inhibited in the absence of AR and ARDeltaCTD., Study shows that genomic instability due to Myc amplification may cause specific amplification of EGFR and/or ERBB2 in gallbladder adenocarcinoma., Heritable genetic variation of ERBB2 is associated with breast cancer., Overexpression of HER2 is associated with gastric cancer., These data provided direct evidence that HER2/neu signaling is essential for tumorigenicity of non-small cell lung cancer cells, Her-2/neu (47.1%), p-53 (31.74%), and their combined expression (15.87%) were not related to grade or stage of tumor in osteosarcoma, Most breast cancer patients with various levels of HER2/neu expression responded immunologically and seemed to benefit from vaccination., Expression of tyrosine-phosphorylated PP2A (pY307-PP2A) was highly increased in the HER-2/neu positive breast tumours, and significantly correlated to tumour progression, thus enhancing its potential prognostic value., A transcriptomic analysis revealed that HER2 carboxy-terminal fragment 611-CTF specifically controlled the expression of genes that we found to be correlated with poor prognosis in breast cancer., The routine assessment of HER2/neu amplification using the ASCO/CAP criteria on whole tissue sections is not significantly confounded by intratumoral heterogeneity in breast cancer with high-grade amplification., Amplification of the Her2/neu gene is a rare event in cutaneous hidradenocarcinoma., directed towards this region of domain III of the HER2, distinct from the well-known monoclonal antibodies trastuzumab and pertuzumab, bind to the HER2 on living cells and exhibit growth inhibition., Her-2 positive breast carcinomas were larger and involved more lymph nodes than Her-2 negative carcinomas, miR-21 is up-regulated via the MAPK (ERK1/2) pathway upon stimulation of HER2/neu signaling in breast cancer cells, expression of phospho-4E-BP1 and HER2 overexpression were the only characteristics with prognostic significance in endometrial carcinoma, HER-2/neu amplification could be regarded as an additional genetic factor playing role in meningioma pathogenesis together with known chromosomal abnormalities, HER2 overexpression correlates with survival after curative resection of pancreatic cancer, Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src-dependent transformed phenotype., Expression of ER, progesterone receptor, and HER2 proteins and the Ki67 index appear to distinguish luminal A from luminal B breast cancer subtypes, findings seem to suggest that obese carriers with minor variant allele of the HER-2 polymorphism may have an increased risk of endometrial cancer and may be consistent with that the HER-2 I655V minor allele variant may be functionally important., Pten functions downstream of ErbB-2 to restrict prostate epithelial transformation by blocking full activation of the PDK1 signaling cascade, although HER2/neu amplification, found in high grade and invasive tumors, is a rare event in transitional cell carcinoma of urinary bladder, The use of anti-HER-2 ribozymes may be a beneficial strategy for gene therapy of breast cancer., Immunodetection of HER2/neu receptor correlated positively with both ERalpha and PR immunolabelling. The Ki-67 proliferation index correlated only with ERalpha immunopositivity., retrospectively examined a series of breast cancer patients with brain metastases for the presence of HER-2, Results showed that 45.8% of typical carcinoid and 28.6% of atypical carcinoid tumors express EGFR, 100% of the tumors lack expression of ErbB2, and 100% have moderate to intense staining for ErbB3 and ErbB4., HER-2 was negative in all NHLs studied using the chromogenic in situ hybridisation test, The 1170 A-P single-nucleotide polymorphism (SNP) in the Her-2/neu protein (HER2) acts as a minor histocompatibility antigen in Acute Myeloid Leukemia., HER-2/neu, and p53 do not seem to play a significant role in the process of high grade transformation of AciCC, Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment., Both ER-beta positive and HER2 positive status was associated with poorer overall survival (OS) by univariate analysis., these results validate the role of miR-548d-3p and miR-559 in regulating the ERBB2 expression., ERBB2 and LRIG1 copy number is increased in breast cancer, findings show that EGFR and ErbB2 can negatively regulate androgen receptor (AR) mRNA and may provide an approach to suppress AR expression in CRPC, high HER2 and EGF protein levels were significantly correlated with TOB1 expression in breast cancer, whereas EGFR and EGF levels correlated with TOB1 phosphorylation, Data demonstrate a more stable binding of heregulin to cells co-expressing HER3 and HER2 than those expressing HER3 alone., Findings highlight an important role for Rac1 in trastuzumab resistance of human breast cancer cells and identify the impaired trastuzumab-mediated endocytic down-regulation of ErbB2 as a novel mechanism of trastuzumab resistance., FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer., Radiation could induce ERBB2 nuclear transport in breast cancer cells., Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization., HER-2/neu expression in extramammary Paget disease, Our results suggest that the described (18)F-FBEM-Z(HER2, Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility., lapatinib inhibits the nuclear translocation of EGFR and HER2 and downregulates TS, thus sensitizing cancer cells to fluoropyrimidine, HER-2 is expressed in breast cancer in the Finnish population at unchanged levels from 1982-2005, In this study there was no association between HER2 plasma levels and cardiac function or left ventricular wall thickness., c-erbB-2 has a complex role in early breast carcinomas, being associated with both favorable (triple-positive) & unfavorable (c-erb-B2 positive after excluding triple-positive and triple-negative tumors)prognosis due to activating different pathways., ER, PR and Her2 have roles in progression of breast cancer, X-ray diffraction data set was collected to 2.45 A resolution for antibody-antigen complex consisting of the single-chain variable fragment (scFv) of chA21 and an N-terminal fragment (residues 1-192, named EP I) of the ErbB2 extracellular domain, results indicate that HER2 status may be a predictive and prognostic factor for cisplatin- based therapy response and disease survival., not over-expressed or amplified in pancreatic adenocarcinoma, miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer, HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation, a subset of patients with HER2-negative primary tumors develops HER2-positive circulating tumor cells during disease progression., HER2/neu expression in Wilms tumor could be a marker for epithelial and homologous differentiation and its expression could be a good predictor for overall survival and longer recurrence free survival., Data show that aberrant expression of ErbB2, ErbB3 and ErbB4 in the two resistant cell lines, suggesting the existence of an autocrine loop leading to constitutive activation of MAPK and PI3K/Akt survival pathways., Increased expression of ErbB-2 is associated with liver cancer., (111)In-DTPA-pertuzumab sensitively imaged HER2 downregulation after 3 d of treatment with trastuzumab and detected a reduction in viable HER2-positive tumor cells after 3 wk of therapy in MDA-MB-361 human breast cancer xenografts., Non-small cell lung carcinoma brain metastases have some significant differences in HER family receptor-related abnormalities from primary lung tumors., Growth of most HER2-amplified cells was inhibited by LY294002, regardless of PIK3CA genotype., Nuclear Y-box binding protein-1 is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer., LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-induced proliferation, a hallmark of ErbB2-positive disease., HER-2/neu increased in high-grade ductal breast tumors compared to DCIS., HER-2 IHC3+/FISH- breast cancer could be a subgroup showing lower histological/nuclear grade and higher expression of ERs/PRs., In univariate analyses, Tau- and ER-positive status were both associated with better DFS and OS (P < .0001) whereas greater tumor size, high grade, lymph node- and HER2-positive status were each associated with worse DFS and OS., ErbB2 promotes glycolysis at least partially through the HSF1-mediated upregulation of LDH-A., Synovial sacromas did not show HER2 protein overexpression or gene amplification., Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer., detachment of mammary epithelial cells from ECM causes an ATP deficiency owing to the loss of glucose transport; overexpression of ERBB2 rescues the ATP deficiency by restoring glucose uptake, In the absence of inhibitors, 3D cultures had substantial impact on HER2 downstream signaling and induced a switch between PI3K-AKT- and RAS-MAPK-pathway activation in all cell lines studied, including cells lacking HER2 amplification and overexpression., HER-2-positive status tended to be associated with a worse 2-year survival, but the overall results were not formally statistically significant., Studies indicate that neither HER-2 status nor topoisomerase IIalpha status can be considered clinically valuable in guiding prescription of anthracyclines., normal and pathogenic ErbB2 signalling may be regulated by ligands in the same way as dEGFR, Her2 overexpression may increase the hTERT transcriptional activation., Serum HER-2 is a useful marker for the detection of recurrence of breast cancer, no difference in metastatic breast cancer survival between HER2-nonamplified and HER2-amplified patients for subgroup as whole, 14-3-3zeta cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition., A subset of human cancers maintain telomere length by a recombination mechanism. This study describes evidentce for this phenotype in a subset of breast cancers with HER-2 overexpression., Depending on the strength of ErbB2 signaling there is a differential regulation of CHOP and eIF2alpha phosphorylation., Survivin-c-erbB2-cox2 co-expression score has independent prognostic value for endometrial cancer., The aim of the current study was to assess the expression levels of c-Src and phosphorylated Src kinase in human breast cancers and to establish if these are linked to oestrogen receptor, progesterone receptor, and HER2 status or patient survival., The incidence of CNS metastases in trastuzumab-treated patients is similar to that in all patients with HER2-positive disease, HER2/neu plays no major role in the development and progression of cervical neoplasia., Her2 is expressed in bilary tract cancer, The ERBB2 gene was neither overexpressed nor amplified in any Wilms tumor case., HER2 phenotype upregulates hTERT through c-myc activation and confers radio-resistance to breast cancer cells., Plasma TNF-alpha and IL-2 levels were positively correlated in ERBB2 positive breast cancer patients., breast tumors with apocrine differentiation are most often of ERBB2 type., HER2 overexpression represents a prognostic factor for adverse urothelial bladder cancer outcome., Report immunogenicity of allo-vesicle carrying ERBB2 tumor antigen for dendritic cell-based anti-tumor immunotherapy., HER2 overexpression was not associated with higher local or regional recurrence in breast cancer., Data identify a novel function for Shc as a regulator of apoptosis and drug resistance in mammary epithelial cells., Aberrant expression of HER2/neu apparently does not contribute to carcinogenesis in the oral epithelium., triple negative (estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2) breast cancer in young women has a significantly poorer prognosis for both disease-free survival rate and overall survival rate., our results support the role of Her-2/neu in acquired hormone resistance., Data show that both full-length and p95-HER2 interact with the HSP90 chaperone protein and are degraded in tumor cells exposed to HSP90 inhibitors., Studies indicate that capsaicin is a novel modulator of the EGFR/HER-2 pathway in both ER-positive and -negative breast cancer cells with a potential role in the treatment and prevention of human breast cancer., SNP HER2 I655V, but not the EGFR R497K, was associated with thyroid cancer risk., Mannosylated ECD/Her2 elicited a humoral response with HER2/neu specific antibodies in vaccinated mice., HER2 receptors are activated at high levels after EGF stimulation in all HER2 expressing human mammary epithelial cell lines., Management of HER2-positive breast cancer in Asia, No relationship of Akt phosphorylation with HER2, ER-alpha or ER-beta expression in breast cancer was found, estrogen receptor (ER), progesterone receptor (PR), and HER2 have roles in breast cancer, Study examined the potential significance of HER2 nuclear expression in DNA repair in breast cancer., 5.1% of invasive bladder carcinomas had a HER2 gene amplification., Ku70 and Ku80 proteins in interaction with AP-2 (alpha and gamma) contribute to increased ERBB2 mRNA and protein levels in breast cancer cells., qRT-PCR showed HER-2/neu amplification in 13 cases of breast cancer, while the standard IHC-FISH combined approach identified 17 HER-2/neu-positive cases., The high expressions of VEGF-C and C-erbB-2 are closely related to lymph node metastasis in breast cancer patients., The expression of 8 proteins, including epidermal growth factor receptor, glutathione S-transferase pi (GST-pi), cyclin D1, Neu/Her-2, C-myc, p53, p27 and p21, were evaluated in 110 cases with cardiac cancer and 101 cases with distal gastric cancer, the HER2 signaling pathway may have a role in radiosensitization in breast neoplasms, a significant association was found between the short tandem repeat (STR) [H(AC)I4] and breast cancer risk at both genotypic and allelic levels, Inhibition of PI3K and mTOR are required for the growth-inhibitory effect of HER2 antagonists, High HER2 is associated with high vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer., simple co-amplification is not the main mechanism leading to patients with both ERBB2 and TOP2A aberrations and the term simultaneous amplification is more precise. ERBB2 amplification is of higher level than TOP2A amplification., The synergism deriving from EGFR and ErbB-2 blockade is mediated by alterations in signal transduction and in the expression of cell cycle regulatory proteins, including transcriptional and posttranscriptional regulation of p27(kip1) expression., inhibition of Notch signaling could antagonize survival signal of Her2-negative breast cancer-initiating cells carrying genomic damage, Our study shows that HER2-overexpressing breast cancer displays characteristic patterns of relapse and metastatic spread depending on estrogen receptor status, Toker cells and mammary Paget cells differ substantially in their expression of ER, c-erbB-2 and Ki-67., Trastuzumab therapy is a treatment option for patients with mucinous carcinoma when the tumor has HER2 amplification and overexpression., Data suggest that Copine-III is a novel player in the regulation of ErbB2-dependent cancer cell motility., Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors, ERBB2 were genes activated in late endometrial endometrioid carcinoma (stages III-IV)., Data demonstrate that sequence differences on the C-lobe surface influence the heterodimerization and activation of ErbB2/4 kinase domains., Metastatic cancer-related hyperprolactinemia and lack of surgery-induced hyperprolactinemia are statistically more frequent in HER2-positive patients., In breast cancer discordant HER2 protein/gene expression is a rare event that is not always explained by the actions of AP-2 and YY1., The HER2 655Val variant may be associated with the incidence of advanced cervical cancer., A relationship between high levels of EGFR and HER-2 in the tumors of patients with esophageal squamous-cell carcinoma and intravascular tumor invasion and poor outcome of the disease was detected., Increased HER-2 is associated with prostatic carcinoma., Studies indicate that lapatinib - a tyrosine kinase inhibitor targets not only EGFR (erb B1) but also erb B2 (HER2) receptor tyrosine kinase signalling., In non-anaplastic thyroid tumours, HER2 was significantly associated with SRC-1, and these proteins were associated with poorly differentiated tumours, capsular invasion and disease recurrence., HER2/neu amplification/overexpression was associated with worse survival in patients with advanced gastric carcinoma., EGFR mutation combined with HER2/3 expression is a significant predictor for gefitinib efficacy on Chinese patients with advanced non-small cell lung cancer., HER2/neu expression is uncommon in these tumors., The expression of HER2 increased after each surgical procedure. However it was lower after CO(2) pneumoperitoneum than after laparotomy., Although the frequency of T cell receptor (TCR) alpha chains with dominant HER2/neu peptide recognition is not known, they may represent interesting tools for TCR optimization resulting in enhanced functionality when paired to novel partner chains., overexpression of ErbB2 promotes invasive and migratory abilities of H-Ras-activated MCF10A human breast epithelial cells through upregulation of matrix metalloproteinase (MMP)-13 and urokinase-type plasminogen activator (uPA)., Interpretive guidelines for HER2 status assay in circulating cancer cells (CTCs) and raise great opportunities for using CTCs as non-invasive and 'real-time' biopsy to examine and monitor the status of tumor markers., The vulnerability of the heart as a pluricellular paracrine organ, Simultaneous downregulation of HER2 and uPAR may offer an effective tool for breast cancer therapy., Use anti-HER2 immunoliposomes to deliver high concentrations of nitroxides selectively to HER2-overexpressing tumor cells for high-contrast electron paramagnetic resonance imaging., ERBB2 influences the expression of Bcl-2 family members to induce an antiapoptotic phenotype., Significant correlation was found between ErbB-2 status and lymphnode status, tumor size and ductal carcinoma, To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group. Low prevalence of Her-2/Neu was observed., The expression of p53, c-erbB-2 and Ki67 proteins in 20 simple intestinal metaplasia (SIM), 27 atypical intestinal metaplasia (AIM), and 37 gastric carcinomas showed significant differences between SIM and gastric carcinomas., Quantified/identified differences in protein levels between tumor and adjacent normal breast tissue from the same breast in 18 women with stage I/II ER positive/Her2/neu negative invasive breast cancer., gene status in endometrial carcinomas, Results suggest that trastuzumab resistance in breast cancer might be overcome by therapeutic strategies that jointly target erbB3, erbB2, and IGF-IR., HER2 overexpression was inversely related to ER expression and PR expression and was associated with a higher tumour grade, lymphovascular positivity and infiltrating ductal carcinoma subtype., ErbB2 tyrosine kinase inhibitor resistance in breast cancer is mediated by calcium-dependent activation of RelA, Data are consistent with a preferential localization of KLF6 in the nuclear compartment of early stage and small HER2-ERBB2 overexpressing ductal breast tumor cells, also presenting lymph node metastatic events, TOP2A gene amplification may define a subset of HER2-amplified breast cancers that are responsible for the markedly improved chemosensitivity seen in HER2-positive breast cancer., both high and low levels of HER2 are associated with poor outcome in breast cancer, findings sustain the ganglioside GM(3) as an essential molecule for EGFR/ErbB2 heterodimer stability and important regulator of EGFR tyrosine phosphorylation, but it is not crucial for tyrosine phosphorylation of the heterodimerization partner ErbB2, The expression of HER-2/neu may play a role in the invasion, metastasis and progression of hepatocellular carcinoma., 150 genes are co-overexpressed with ERBB2; these genes represent factors influencing ERBB2-positive tumors. RNAi based analysis of these genes identifies transcriptional regulators of fat synthesis and storage as critical for the cell survival., The expression of c-erbB-2 in lymph nodes was statistically significantly related to the expressions of EGF and EGFR both in the main mass of tumour and in lymph nodes., Altogether, these findings support the notion that HPSE is a critical downstream target of HER2 mechanisms driving BMBC and is potentially relevant for BMBC therapeutic interventions., Although our study provides additional evidence of the potential prognostic role of c-erbB-2 in endometrioid carcinoma, further prospective and controlled studies are required to validate their clinical usefulness., Breast cancer tissues predefined for HER2 status were subjected to MALDI-IMS, and protein profiles were obtained.We found that specific protein/peptide expression changes strongly correlated with the HER2 overexpression., HER-2 alterations specifically correlate with clinicopathological characteristics of Bulgarian patients with breast cancer., HER2 may have a role in response to trastuzumab in patients with metastatic breast cancer, Pin1 plays an important role in the overexpression of HER-2 through Pin1-MEK1-activator protein-2alpha signaling in breast cancer., The effect of lapatinib on ERalpha signaling varied markedly depending on the nature of the HER2/ERalpha cross-talk, Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains, Real-time RT-PCR analysis for evaluating the HER2/neu status in breast cancer is reported., Cyclin A2 and HER2 are associated with proliferation and high recurrence, particularly when combined., Suggest that HER-2 shRNA-based combined therapy with paclitaxel could be a novel strategy to inhibit the progression of HER-2-positive nasopharyngeal neoplasms., Ethanol enhances the adhesion of breast cancer cells to fibronectin in an ErbB2-dependent manner., is expressed in breast cancer and metastatic lymph nodes, EGFR, HER-2 and HER-4 expression is not associated with poorer survival in neuroendocrine cancer, Statistically significant correlation between mRNA and protein expression for HER2 in breast cancer patients., No relationship was found between HER2 expression and patient survival., We observed overexpression of HER-2/neu receptor in teratocarcinoma subtype of germ cell tumor, The study reports the first evidence for a correlation between cPLA(2)alpha enzymatic activity and overexpression of the HER2 receptor., Studies indicate a possible role of Her-2 as a prognostic factor in bladder carcinoma., The cells with high Her2/neu protein gene amplification and/or protein overexpression can be detected and analysed even if their amount in the sample is small. Chromosome 17 polyploidy is important in some cases., Presence of Foxp3+ tumor cells represents a new independent prognostic factor of improved outcome in HER2-overexpressing breast carcinoma, which could help identify high-risk patients for additional therapies after neoadjuvant chemotherapy., HER-2 over-expressing breast cancer cells resistant to trastuzumab can be targeted for selective gene expression and destruction by viruses with envelope-proteins engineered to bind to this antibody., beta2-adrenergic receptor is up-regulated in MCF-7 cells overexpressing Her2 and Her2 overexpression plus phosphorylation of ERK cause epinephrine autocrine release resulting in up-regulation of beta2-adrenergic receptor in a positive feedback loop., Overexpression of c-erbB-2 is associated with lung cancer., ILK has a critical role in the initiation phase of ErbB2 tumor induction., Data show that HER-2 gene amplification is a potential prognostic marker for advanced stage breast cancer., Elevated expression of C-erb-B2 may reflect pre-neoplastic liver cell proliferation, cellular necrosis associated with HCV related chronic liver disease and alternatively from HCV carcinogens which enhance malignant transformation., TRMT2A protein expression as a biomarker of increased risk of recurrence in HER2+ breast cancer patients., ER+/PR- tumors more frequently showed HER2 (human epidermal growth factor receptor) overexpression and represent a distinct subset in familial breast cancer patients., c-erbB2 overexpression seems to predict aggressive behaviour in supratentorial anaplastic astrocytomas., Integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim., The positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer., data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation, Combining CEA with Cyfra 21-1 analysis of malignant pleural effusion increases diagnostic sensitivity of lung adenocarcinomato nearly 100%, tumor marker for breast cancer, In the adjuvant breast cancer setting, primary fluorescence in situ hybridization testing with subsequent trastuzumab treatment of HER-2-positive patients is a cost-effective and preferable approach., HER-2 gene amplification and protein high expression is associated with salivary duct carcinoma., Patients with HER2 positive breast cancer had increased pathological complete remission rates, but survival rates were worse, especially in those with residual disease after preoperative therapy., The P53 gene codon 72 and Her-2 gene polymorphisms were not associated with the risk of breast neoplasms in Turkish women., In HER2-positive breast cancer, basal co-expression of PTEN and p-Akt might identify those patients who are more likely to benefit from trastuzumab-based therapies., Meta-analysis suggests that HER2 Ile 655Val polymorphism may contribute to breast cancer risk., Data show that information on the HER2 status of CTC might be helpful for stratification and monitoring of HER2-directed therapies., HER2 gene amplification activates lamellipodia formation in breast cancer cells, which initiates their metalloproteinase-independent migration, The combination of S-1 and HER2-targeting agents is a promising treatment option for gastric cancer with HER2 amplification., EGFR and Her-2 may not have a role in oral squamous cell carcinoma, but there are low levels of EGF in saliva during disease progression, Results suggest that the expression of c-erbB-2 and EGF protein, but not necessarily ERG receptors, can help predict the postoperative survival time in stomach cancer., Results indicate that Muc4 modulates ErbB2 signaling potential significantly by stabilizing and directly interacting with the ErbB2-ErbB3 heterodimer., This paper briefly reviews the assessment of ERalpha, PgR, and HER2 in breast cancer, emphasizing recent progress and persistent controversies., Testing of Her2 status in gastric cancer predicts outcome, compared with outcome in breast cancer., Cyclin D1 functions downstream as a genetic target of Notch1, amplifies Notch1 activity by repressing Numb, and identifies a novel pathway by which ErbB2 induces Notch1 activity via the induction of cyclin D1., The dimerization partner of EGFR, ERBB2 is also a possible low penetrance gene candidate associated with risk of glioblastoma development., High levels of HER2 and Ki-67 or TK1 expression correlate with the increase of tumor grades and tumor recurrence in meningiomas., HER2-mediated signaling effects low molecular weight cyclin E expression, which in turn deregulates the cell cycle., data demonstrate that aberrant Notch regulation is an early event in mammary carcinogenesis and is associated with the HER-2 molecular subtype of breast cancer, Lapatinib, a dual tyrosine kinase inhibitor of EGFR and HER-2 receptors demonstrated antiangiogenic/antitumor effects in a lung cancer model., in gastric cancer cells, HER2 knockdown resulted in the downregulation of the expression of MMP-1, while HER2 overexpression improved the transcription of MMP-1 through the activation of an MMP-1 promoter, Results describe the structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 and suggest an important contribution of the transmembrane helix-helix interaction to signal transduction., While for endocrine responsive and Her2-positive disease different molecular targeted therapies are available, up to now no specific targeted approach for triple-negative breast cancer has been developed., Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion., In HER2-positive breast tumor patients, trastuzumab added to epirubicin/cyclophosphamide/docetaxel leads to increased pCR rates., The use of estrogen receptor/progesterone receptor/HER2 subtypes and correlation with molecular classification of breast cancer is recommended., There is no correlation between HER2/neu overexpression and the tumor stage., prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth, Results support the biological relevance of elevated HER2/ECD levels in the outcome of HER2-disease and in the susceptibility to Trastuzumab-based therapy., Meta-analysis suggests that HER2 codon 655 polymorphism is not associated with the increased breast cancer risk., Analysis revealed an association between HER2 protein expression and gene amplification in breast carcinoma. 14% of colon carcinomas, 2% of prostate carcinoma, 4% of lung carcinomas and 16% ovarian carcinomas revealed gene amplification., HER2 and TUBB3 status might be a good biomarker for determining the most appropriate therapeutic modality in extramammary Paget disease., High expression of ErbB-2 found in brains of meningioma patients implicates a potential role for ErbB-2 in benign tumorigenesis of meningioma consistent with interactions of ErbB-2 homodimers that may be associated with low signal transduction., Case Report, Data show that the concordance rates of histological type, estrogen receptor and progesterone receptor status, and HER2 were 84.4%, 81.3%, 92.9%, and 89.3%, respectively between CNB and surgical specimens., HER-2/neu and TOPOIIalpha amplification/overexpression might discriminate between Barrett's oesophagus, dysplasia and adenocarcinoma., An overexpression of Her2 was found in one anorectal melanoma., HER2, but not EGFR gene amplification, is frequently observed in KRAS and BRAF wild type colorectal cancer patients, htid is a tissue independent and evolutionarily conserved suppressor of ErbB-2., Data show that a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001>, c-erbB2 was altered in 45% of the oral squamous cell carcinoma samples from a Serbian population. Statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis., observations suggest that PI3K mutants enhance HER2-mediated transformation by amplifying the ligand-induced signaling output of the ErbB network, Phase II study of nab-paclitaxel, bevacizumab, and gemcitabine as first-line therapy for patients with HER2-negative metastatic breast cancer., The ability of apical ErbB2 to initiate an altered downstream cascade suggests that subcellular localization of the receptor plays an important role in regulating ErbB2 signaling in polarized epithelia., analysis of CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients, In some oral squamous cell carcinomas Her-2 immunohistochemical expression may be associated with chromosome 17 polysomy and not Her-2 amplification., controls expression and cellular localization of ZO-1 tight junction protein, Data showed a positive correlation between HER-2 and COX-2 or VEGF-C mRNA levels in breast cancer., Monitoring serum HER2 levels in the presence of anti-HER2 treatment might be an adjunct to the clinical evaluation during neoadjuvant chemotherapy of breast cancer., HER2-overexpressing esophageal squamous cell carcinomas tumour cells showed a reduced sensitivity for CTLs through the downregulation of MHC class I., study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort, Her-2/neu protein over-expression is significantly associated with advanced surgical stage uterine papillary serous carcinoma and poor survival outcome., this study did not find HER-2 expression to be an independent factor of either tumour progression or cancer-specific survival., We describe a tool (a customized Excel spreadsheet) for easy and reproducible diagnosis of HER2 genetic heterogeneity according to ASCO/CAP criteria., Study does not confirm the hypothesis that sunitinib consolidation therapy can lead to a predefined clinically relevant proportion of HER2-negative breast cancer patients with PFS of > or =5 months after an objective response to taxanes., The aim of our study was to develop and optimize methods for relative and absolute protein quantifications in formalin-fixed and paraffin-embedded (FFPE) tissues with special emphasis on HER mediated pathways in breast cancer., the ratio of ErbB1 and ErbB2 in their heterocluster, High-level HER-2 amplification occurs in a small fraction of colorectal cancers., The combination of nab-paclitaxel and cyclophosphamide, with or without trastuzumab, is feasible and well tolerated in patients with early stage HER-2 positive breast cancer., The effect of lapatinib on HER2 protein extracellular domain shedding and its effect on trastuzumab and geftinib pharmacology in breast cancer cells are reported., Report determination of the Her-2/neu gene amplification status in cytologic breast cancer specimens using automated silver-enhanced in-situ hybridization., There is a consistent association of HER-2/neu over expression and Gleason less than 7 with a higher RR of death and recurrence in patients with prostate cancer, Pre-clinical models have indicated a role for HER2 signalling in initiating Chromosomal instability and defective cell-cycle control., The HER2 positivity rate of breast tumors (DIN1C-3, invasive carcinoma) may be as low as 9%. Immunohistochemistry as firstline testing for HER2 may result in false positive and false negative results., Data suggest a role for VRK2A in ErbB2-MAPK signaling., Studies indicate that tumor grade and race were associated with HER-2 for women aged >/= 50 years after controlling for other variables., Results, besides corroborating existing reports that discrepancies exist between HER2 ISH and IHC assays, also suggest the need to rigorously evaluate CISH as an independent reference standard for assessment of HER2 amplification in gastric cancers., Neu/V664E TM domain does not affect the phosphorylation levels of full-length FGFR3/A3, The addition of progesterone receptor and HER2 to Nottingham Prognostic Index increases its 5-year prognostic accuracy in breast cancer., HER2 over-expressing tumors may be more prone to escape from HLA-A2 restricted cytotoxic T lymphocytes (CTLs)., Data revealed the significance of HER2 in the radio-resistance of HER2(+) breast cancer cells through induction of transcription factors NF-kappaB and c-myc, leading to activation of survivin, a downstream target oncogene preventing apoptosis., HER2 was up regulated in prostate cancer epithelium while CMTM5 was down regulated. Overexpression of CMTM5 in PC3 cells could lower the HER2 and Cyclin D1 protein level., Data indicate that high ErbB2 expression enhances cholangiocarcinoma invasion, motility and proliferation via the AKT/p70S6K pathway., Insights into biological processes that come under the control of HER-2 after it acquires full oncogenic potential in a breast cancer cell line., FISH is recommended as the primary HER2 testing modality for women with breast cancer who are candidates for HER2-targeted therapies., High HER2 gene copy number in tumor epithelial cells is associated with non-small cell lung cancer., Findings suggest that breast cancer developing on a background of an inherited TP53 mutation is highly likely to present with amplification of HER2., Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells., ILK regulates the expression of Her2/neu through TWIST and YB-1, lending support to the use of ILK inhibitors in the treatment of aggressive Her2/neu-positive tumors., Her-2 and basal-like subtypes of breast cancer are correlated with factors associated with a poor prognosis., While HER2 amplifications appear to be prevalent in select non-breast tumors, lapatinib monotherapy is associated with modest activity., Compare HER2 status of circulating tumor cells in patients with metastatic breast cancer using two different methods., Her-2 and VEGF may play synergistic roles in the occurrence and development of breast cancer. Over-expressions of Her-2 and VEGF predict poor prognosis., Patients with Ile-Val & Val-Val genotypes had significant TNF-alpha elevation compared with homozygous Ile-Ile patients. TNFA's negative impact on survival seems to be enhanced through the interaction with HER-2 Ile655Val SNP., Studies indicate that breast carcinomas Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features, The mechanism of HER2Delta16 therapeutic evasion, involving tamoxifen-induced upregulation of BCL-2 and suppression of miR-15a/16., PTEN expression at both mRNA and protein levels were not significantly affected by erbB2 silencing (P>0.05)., Mutations in ERBB2 is associated with adenocarcinoma of the lung., Results propose a model for HER2-EGFR dimerization and possible blocking by HERP5 peptidomimetic using a protein-protein docking method., estrogen receptor, progesterone receptor, and HER-2 may have a role in progression in breast cancer despite response to doxorubicin/cyclophosphamide therapy, Information on presence or absence of HER2 overexpression can be obtained in circulating tumor cells., HER2/neu is a marker of prognostic significance that is routinely assessed in invasive cancer., HER2 gene genetic heterogeneity was associated with HER2 protein expression and ER expression., ER+ and ER- ERBB2-amplified BCs are different, and ERBB2 amplicons in inflammatory breast cancer and non-inflammatory breast cancer can be distinguished, Data suggest that TGF-alpha plays a role in resistance to lapatinib and capecitabine therapy among HER2-positive breast cancer., ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2., JNK1 promotes cell survival in Her2/neu-positive breast cancer, Focusing on the mechanisms that confer resistance to individual HER2 targeting agents, this review envisage therapeutic approaches to delay or overcome the evolvement of resistance in patients. [review], HER2 molecular subtype is the dominant, but not the sole subtype seen in Paget's cells of the nipple, Analyses indicate that p130Cas expression in ErbB2 positive human breast cancers significantly correlates with higher risk to develop distant metastasis, thus underlying the value of the p130Cas/ErbB2 synergism in regulating breast cancer invasion., ERRalpha and PGC-1beta are key players in the etiology of breast cancer by coordinating the transcriptional regulation of genes located in the 17q12 region, a process that also involves interference with the repressive function of ERalpha on ERBB2 expression., EGFR and HER-2 expression is variable in embryonal brain tumors, ErbB-2 signaling via the phosphatidylinositol 3-kinase pathway results in up-regulated matriptase zymogen activity, which contributes to prostate cancer cell invasion., This review discusses the molecular mechanisms leading to the development of trastuzumab resistance, including circulating HER2 extracellular domain, loss of PTEN, activation of alternative pathways (e.g. IGFR), and receptor-antibody interaction block., Fatty acid synthase expression and activity has emerged as a common phenotype in most human carcinomas, including breast cancer., Her-2 expression is an important prognostic factor in patients with node-positive breast cancer, but not for patients with node-negative disease in Chinese women., ER, PR and Her-2 are independent prognostic factors for locoregional recurrence and survival in node-positive breast cancer patients treated by mastectomy., The study also showed that HER2/neu amplification is higher in Saudi patients than other western populations., HER2 may induce breast cancer by increasing the frequency of tumor stem cells and upregulating the expression of COX-2 and HDAC6 that play pivotal roles in tumor progression., in ER negative basal and HER2+ breast cancer, gene expression modules reflecting T-cell helper-1 (Th1) and T-cell helper-2 (Th2) mediated immune responses play antagonistic roles as major risk factors for distant metastasis, Data suggest that HER2 overexpression may constitute a unique molecular event independent of the tumor site., Concomitant expression of HER2 (protein tyrosine kinase-type cell surface receptor HER2 ) and HIF-1alpha (hypoxia inducible factor 1 alpha) is a predictor of poor prognosis in uterine cervical carcinoma treated with concurrent chemoradiotherapy, Study shows the pivotal roles of Dmp1 in HER2/neu-p53 signaling and breast carcinogenesis., COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer, Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90., Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas., HER2 protein overexpression and gene amplification are infrequent events, if they occur at all, in small intestinal adenocarcinoma., HER2 overexpression or gene amplification is involved in the transition from DCIS to invasive disease., Findings reveal a novel mechanism through which HER2 silences tumor suppression in a concerted manner by switching expression of C/EBPss isoforms., The breast cancer patients with co-overexpression of ErbB-1 and ErbB-2 had a shorter disease free survival., Prolactinoma HER2 potently induces prolactin and regulates experimental prolactinoma cell proliferation., HER2 seems not to be of such interest for radionuclide therapy due to rare expression in colorectal carcinoma, Adding carboplatin did not enhance TH antitumor activity.TH (docetaxel, 100 mg/m(2)) and TCH (docetaxel, 75 mg/m(2)) demonstrated efficacy with acceptable toxicity in women with HER2-amplified MBC., the HER pathway is blocked by lapatinib and trastuzumab in HER2/neu-overexpressing breast tumor xenografts, Studies indicate that aUPD is a common and non-random molecular feature of breast cancer that is most prominent in HER2/ER/PR triple negative cases., meta-analysis suggests that HER2 overexpression is a poor prognostic factor in lung cancer, Trastuzumab-DM1 has robust single-agent activity in patients with heavily pretreated, HER2-positive metastatic breast cancer and is well tolerated at the recommended phase II dose., The Ventana HER2 dual-color ISH assay is robust and reproducible and shows good concordance with a standard FISH assay., Inhibition of CaM function or deletion of the CaM binding sites from HER2 significantly decreased both HER2 phosphorylation and HER2-stimulated cell growth., These data indicate that the activation and/or overexpression of SST receptors along with the inhibition of EGFR will serve as an important therapeutic approach in the treatment of ErbB-positive tumors., HER-2 expression significantly correlates with Survivin at the protein level in primary invasive ductal breast cancer tissues, HER receptor family plays an important role in embryonic development and in pathogenesis and progression of neuroblastic tumors., No statistically significant correlation was found between HER-2/neu codon 655 polymorphism and breast cancer., hMena and HER2 signalling has a role in breast cancer, epidermal growth factor receptor-2, HER-2 overexpression is associated with M1b prostate cancer., Expression of ADAM 10 in gastric cancer is significantly associated with lymph node and distant metastasis, high C-erbB-2 expression, and poor prognosis., No correlation was noted between HER2/neu, ER or PR status, and blood group type. Among this cohort, HER2/neu positivity was less than 20%, More positivity HER2 was found in advanced stages (III/IV) vs. early stages (I/II); intestinal histology subtype vs diffuse/ mixed and gastro-oesophageal junction cancer vs GC, HER2-positive Circulating Tumor Cells were detected in DCIS/LCIS or M0 breast cancer irrespective of the primary tumor HER2 status. Nevertheless, their presence was more common in women with HER2-positive disease, Her-2/neu gene amplification is associated with esophageal adenocarcinoma., quantifying EGFR/HER2 heterodimers using our antibody-based TR-FRET assay may represent a useful method to predict the efficacy and explain the mechanisms of action of therapeutic mAbs, HER2 amplification seems to drive genomic instability along chromosome 17q, leading to different patterns of gene amplification., Our study does not support a role for human epidermal growth factor receptor 2 as a prognostic marker in osteosarcoma., Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity., Patients who changed HER2 status from negative to positive, presented significant longer time to progression when treated with trastuzumab compared to those who were untreated, Our results showed that dual-color SISH is a viable alternative to FISH for assessing HER2 gene amplification in breast cancer., HER2 gene amplification and protein over-expression is associated with esophageal carcinoma., HER overexpression orchestrates broad changes in the tumor microenvironment by altering the secretion of a diverse variety of biologically active proteins., Results support the hypothesis that Her-2/neu overexpression contributes to tamoxifen resistance., HER2-positivity is present in a significant proportion of oesophago-gastric adenocarcinomas (24%), but at a lower rate in the distal stomach, HER2 gene amplification was found in 41% of Vietnamese breast cancers., Trastuzumab plus chemotherapy in gastric cancer overexpressing HER-2 and EGFR, Coexisting HER2 gene amplification and novel mutations in the HER2 protein-overexpression are associated with mucinous epithelial ovarian cancer, gene mutationa are not associated with the prognosis of patients with lung cancers, In hormone-independent breast cancer cases negative for CerbB-2, Ki-67 and P53 expressions were significantly higher than that in hormone-dependent CerbB-2-negative cases., COX-2 overexpression correlates with HER2 overexpression in invasive breast carcinomas and may provide a clinically useful biomarker for estimating tumor aggressiveness., Data suggest that since PTK6 plays an important role in HER receptor signal transduction, its down-regulation might be suitable for future therapy approaches in breast cancer., Bevacizumab combination therapy improves clinical benefit in terms of increased progression-free survival in first-line treatment of Her-2 negative metastatic breast cancer., therapeutic inhibitors of HER3 should be used in combination with HER2 inhibitors and PI3K pathway inhibitors in patients with HER2- and PI3K-dependent cancers, We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues., Hunk is required for HER2/neu-induced mammary tumorigenesis, Results indicate a significant association between HER2 expression and age., HER-2 expression, however, might play an important role in predicting the prognosis of lipid-rich carcinoma of the breast., Data show that moderate- to high-affinity mAbs targeting the same HER2 epitope with monovalent affinity above 23 nmol/L had equal tumor accumulation of residualizing radiolabel over 120 hours., 148 Penile squamous cell carcinoma were microarrayed and immunostained for phosphorylated EGFR (pEGFR), HER2, HER3, HER4, phosphorylated Akt (pAkt), Akt1 and PTEN proteins., HER2 was overexpressed in 30/44 pT1GIII lesions & predicted recurrence in this subgroup of bladder transitional cell carcinomas. Expression was negative in 26/40 pT1GII tumors, As malignancy further progressed, we identified a subset of cells harboring HER2 amplification, Conserved intramolecular non-covalent bond networks across ErbB2 family kinase are identified that emerge from sequence homology and lead to conserved dynamic characteristics as well as function., The existence of amplified HER2 in cfDNA in the follow-up of breast cancer patients who are otherwise disease free., A comprehensive immunohistochemical study was performed to investigate the protein expression of eight CT genes in 454 invasive ductal carcinomas, including 225 ER/PR/HER2-negative (triple-negative) carcinomas., in ileal neuroendocrine cancer, HER-2/neu overexpression plays a role in the carcinogenetic process and by triggering the altered expression of c-Met and MTA-1, may activate the molecular pathway(s) promoting tumor progression and metastasis development., Majority of patients with HER-2/neu negative breast cancer had HER-2/neu-specific IFN-gamma producing T cell responses which was stronger than those in patients with HER-2/neu positive tumors., Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein., HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation., we have found that HER2 amplification does not associate with poor prognosis in total 232 esophageal adenocarcinoma patients, These findings point to the role of HER2-positive exosomes in modulating sensitivity to trastuzumab, and, consequently, to HER2-driven tumor aggressiveness., High HER2 protein expression is associated with gastric carcinomas., Detection of HER-2 gene amplification can assess the malignant biological behaviors and prognosis of gastric cancer., C-erbB-2 and EGFR might have a synergetic effect in the development and progress of nasopharyngeal carcinoma. Co-expression closely correlates with cell proliferation status., It is unlikely that HER2 rs1136201 is a risk factor for breast cancer., Data show that (99m)Tc-labeled 2Rs15d has a high tumor uptake in HER2(+) tumor models., plasma copy number variation can be used as prognostic marker for esophageal cancer, Suggest PTPN12 and ERK5 mediate HER2-driven cell motility in ovarian cancer cells, through FAK targeting., Studies characterized the anti-human epidermal growth factor receptor 2 (HER2) mAb produced in a glycoengineered Pichia., ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in breast cancer, In invasive breast cancer ER is negatively associated with HER-2 amplification, whereas tumor emboli and lymph node status are positively associated with HER-2., We evaluated HER2 protein expression and gene amplification in micropapillary carcinoma, we demonstrate that a significant number of oesophageal adenocarcinomas are positive for ErbB2, IHC can be used firstly to screen the HER-2/neu status, and FISH can be used as a supplementary role to IHC and 2+ and some negative cases., HER-2/neu gene amplification by CISH was found in 10 (20%) out of 50 patients with borderline (2+) IHC score., Copy number increase of ERBB2 is observed in OSCCs and correlates with gene overexpression in these tumors. In addition, overexpression of ERBB2 is also observed in some OSCCs that lack copy number changes, indicating involvement of another mechanism., These studies indicate that TSP1 disrupts the endothelial barrier through EGFR/ErbB2 activation although additional signals are necessary in cells with low receptor expression., prognostic significance and impact of p53 protein and human epidermal growth factor receptor 2 (HER2) overexpression on 5-year survival in young patients with stage II breast cancer, The pre-therapeutic beta-catenin and Her2/neu protein expression seem to be valuable predictive and prognostic markers in the multimodality treatment of advanced rectal cancer., we report on the production and purification of a soluble anti-HER2 scFv antibody secreted by Pichia pastoris., These findings illustrate appropriate and effective implementation of a HER2 testing strategy in a managed care setting., The association for ER-/PR- tumors did not differ by expression of HER2 (p(heterogeneity) = 0.3)., Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells., findings indicate that nuclear ErbB2 functions as a regulator of rRNA synthesis and cellular translation, which may contribute to tumor development and progression, the Delta16HER2 splice variant represents the transforming form of the HER2 oncoprotein, p185 as a naturally occurring autoantigen mimotope, elevated levels of HER2 are a negative prognostic factor and patients overexpressing HER2 show a significant increase of overall survival when treated with trastuzumab, HER-2 and p53 have important prognostic value in breast cancer and should be considered collectively., Devised a novel flow cytometric method to quantify the expression of ERalpha, HER2, and the activation of ERK1/2 simultaneously in single cells., HER2 expression level is directly related to breast cancer invasion., Expression of HER2 is associated with clinicopathological features in gastroesophageal cancer., HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population, estrogen receptor(ER) and progesterone receptor(PR) expressions were inversely correlated with HER2 protein expression and ER but not PR expression is inversely correlated with Her2 gene amplification in ovarian cancer, following irradiation, HER2 receptor activates hTERT/telomerase, increasing the breast cancer cells' survival potential, through sequential induction of transcription factors NF-kappaBeta and c-myc, Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix., In situ detection of HER2 and HER2, Her2 amplification in metastasising bladder cancer is relatively frequent, is homogeneous in each tumour component, and predicts early death., For women = 35 years, TP53 mutations, Ki67 and HER2 expressions are strong prognostic factors., A change between primary breast tumour and corresponding relapse is frequent for progesterone receptor, infrequent for estrogen receptor and rare for HER-2., The study included a total of 28 cases of urothelial carcinomas, which were analyzed histopathologically and immunohistochemically using anti-human p16, c-erbB2 and Ki67 antibodies., Expression of ER, HER2, and TOP2A displayed discordance with a sufficient frequency to emphasize the role of confirmatory biopsies from metastatic lesions in future management of recurrent breast cancer., HER2 overexpression caused by gene amplification was observed in about 20% of patients with salivary duct cancers but was rare in salivary adenomas and other carcinomas., truncated ErbB2 rendered cells resistant to lapatinib-induced apoptosis., study concluded that in breast cancer, HER2 status was correlated with HER2 protein expression levels; frequency of polysomy 17 was correlated with the HER2 copy number and partially contributed to HER2/neu amplification but not HER2 protein expression, Menopausal status played a very important role in determining HER2 and PgR status in ER(+) breast cancer patients. HER2 was independently inversely associated with PgR only in the postmenopausal women with ER(+) breast cancers., Results indicate that amplification of TOP2A in breast cancer is not confined to those who are concomitantly HER-2/neu(+), and suggest that a significant proportion of HER-2/neu(-) patients exhibit high levels of TOP2A., There was no association between HER2/neu and VEGF expression among 317 colon cancer patients with all tumor stages. HER-2/neu expression was significantly correlated with tumor size & distant metastases., GRP94, FN14, and inhibin have roles in brain and non-brain metastases in ErbB-2+ and ErbB-2- breast neoplasms, HER2 amplification was significantly related to worse survival in gastric cancer., our data suggest that Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival., Iionizing Radiation-induced, but not EGF-induced phosphorylation of cytoplasmic and/or nuclear Akt-S473 is erbB2 dependent., IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance., The first quantitative and qualitative analysis of the poly (A) transcriptome of two human mammary cell lines, differentially expressing human epidermal growth factor receptor, is reported., Multifocal/multicentric invasive ductal carcinomas usually have a single phenotype in terms of hormone receptors, human epidermal growth factor receptor 2, and molecular subtypes., Using immunohistochemistry, our data showed that the association between HER2/neu overexpression and patient survival provides a good indirect validation for quality of this investigation and it may act as a prognostic parameter in gastric cancer., Data show that HER2 overexpression enhances Notch3 promoter activity in mammary epithelial cells., Data show that the triple-negative and HER2 subtypes were associated with poorer outcomes compared with the luminal A subtype., Sarcosine may induce prostate cancer progression by increased HER2/neu expression., There was a significantly positive association between HER2 expression status and tumor differentiation and histological type in Chinese patients with gastric carcinoma., Dual-colour chromogenic in situ hybridization is an excellent alternative for the evaluation of HER2 genomic status in gastric cancers., percentage of tumor cells with HER2/CEP17 ratios more than 2.20 does not identify cases with heterogeneous amplification or poor outcome, Early onset HER2-positive breast cancer is associated with germline TP53 mutations., Data show that triple-negative breast cancer (TNBC) are larger in size compared with other subtypes and almost all grade 3., Her-2 over-expression was found to be more common in esophageal adenocarcinomas. (Review), Inhibition of EGFR and Her2 phosphorylation by Lapatinib is shown to be associated with the inhibition of Akt phosphorylation., These results suggest that down-regulation of miR-205 in erbB2-overexpressing breast epithelial cells is essential for erbB2-induced tumorigenesis., Her2 gene amplification was detected in 0 of IHC score 1+, 24/86 (27.91%) 2+, and 8/13 (61.54%) 3+., These results support GDF15-mediated activation of TGF beta receptor-Src-HER2 signaling crosstalk as a novel mechanism of trastuzumab resistance., Data show that C-erbB-2 protooncogene alteration is an early phenomenon in glial tumor development and progression., mathematical model predicting the fraction of proliferating breast cancer cells in G1, S, and G2/M phases of the cell cycle as a function of EGFR and HER2, Alterations of tumor suppressor genes such as CDKN2A and oncogenes such as ERBB2 play a role in the progression of intestinal metaplasia to adenocarcinoma in patients with Barrett's esophagus., A significant proportion (21.3%) of patients with equivocal IHC(2+) test results show amplification of the HER2 gene., We confirmed evidence that discordance of ER/Her2 expression between primary and metastatic breast carcinoma does occur., Data show that overexpression of ErbB2 maintains PDH flux by suppressing PDK4 expression in an Erk-dependent manner., multivariate analysis, which used luminal A subtype in old patients as reference, indicated that HER2 subtype in young patients was associated with increased risk of ipsilateral breast tumor recurrence, Because IHC is recommended before gene amplification studies in HER2 testing, gastric cancer scoring system should be used for evaluating HER2 expression in gastric cancers., Metformin decreased erbB2/insulin-like growth factor-1 receptor complexes without altering erbB2 expression., Breast cancers HER2-indeterminate (2+) by HercepTest IHC can be strongly separated into those probably HER2 amplified, a core indeterminate group and those probably not HER2 amplified., Data show that hierarchical clustering based on mRNA expression of estrogen receptors, progesterone receptor and neu receptor by quantitative RT-PCR identified patient groups that were comparable to the subtypes identified by immunohistochemistry., demonstrated that ER-alpha36 positively regulates HER2 expression and the population of ALDH1 positive breast cancer cells, and suggested that non-genomic estrogen signaling mediated by ER-alpha36 is involved in maintenance of breast cancer stem cells, HER2 oncogenicity is dependent, not only on its constitutively active nature, but also on its ability to muster collaborative signaling from family members through modulation of ligand-induced receptor regulation, results indicated that expression patterns of ER, NM23-H1, and HER2 in primary breast cancer lesions warn that cells might have metastatic potential, Meta-analysis, The expression of leptin, OB-Rb and HER-2 was significantly higher in non-small-cell lung cancer (NSCLC) tissues than in normal lung tissues. The expression of leptin is an independent prognostic factor for NSCLC., Results suggest that Rab7 is likely involved in protecting EGFR and Her2 from being degraded by the proteosome and in maintaining optimal tumor cell Akt survival signal., data suggest that stratification of CaP patients for HER2/3 and PTEN status could identify patients with aggressive CaP who may respond favorably to MEK inhibition, This study revealed a novel mechanism of Akt2 regulation by ErbB2 in prostate cancer cells., The results indicated a significant correlation between HER-2/neu and grade, but an inverse relationship between HER-2/neu and hormone receptors in breast carcinoma., Data show that Rac1 was highly activated in PTEN deficient and IGF-IR overexpressing Trastuzumab-resistant cells in a HER2-independent manner., Report population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer., Her2-Neu was expressed in 36.1% of 122 Mexican breast cancer patients. There was a close with relation the tumour size & the presence of lymph node metastases but not with age, differentiation or estrogen receptors., Results suggest for the development of a Her2-targeted treatment option for this new patient subgroup of oesophageal adenocarcinoma., Cinical study indicates that co-overexpression of Her2 with GEP100 in primary lung adenocarcinomas of patients is correlated with the presence of their node-metastasis with a statistical significance., HuR and miR-331-3p participate in the overexpression of ERBB-2 observed in some PCas., The tumor was finally discovered to overexpress the ERBB2 protein and the patient responded well to trastuzumab plus 2 cytotoxic agents., For patients with HER2-overexpressing gastric cancer, there is an improved prognosis with additional trastuzumab to chemotherapy with a platinum compound and a fluoropyrimidin in first-line therapy., A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion., This study shows that the HER2 codon 655 G-allele was associated with a larger reduction in plasma HDL-C levels in breast cancer patients under tamoxifen therapy., the feasible dose for lapatinib, a dual HER2/EGFR tyrosine kinase inhibitor, with paclitaxel and gemcitabine as a neoadjuvant treatment in HER2 positive patients., HER2 genetic heterogeneity is frequent in breast carcinoma, and is most often present in carcinomas with an equivocal (2+) HER2 score, Antisense oligodeoxynucleotide targeting HER2 mRNA sensitized breast cancer cells to docetaxcel treatment., We have shown that TGF-beta1 expression in gastric tumor tissue with HER2/neu-negative status is of prognostic relevance in gastric cancer., Gene expression signatures comprising 24, 51 and 14 genes predictive of ER, PR and ERBB2 status respectively, were investigated., There was no significant correlation between patient age, the various histological types, tumor grade, and Her-2/neu positivity in breast carcinoma, Data show that cyclin D3 is significantly upregulated in breast cancers and frequently exceeds the expression of Cyclin D1 in ErbB2-positive cases., Results suggest that co-expression of androgen and estrogen receptors can provide a protective effect based on phenotypical presentation of HER2-positive carcinomas., The gene expressions of PCNA, c-erbB-2, and p53 gradually decreased with the increased distance from primary tumor (P < 0.05)., HER-2/neu overexpression may be used as an independent prognostic factor for intestinal-type and early-stage gastric cancer patients, The soluble production of the novel scFv800E6-EGFP protein in the cytoplasm of Escherichia coli was investigated at different induction temperatures (25, 30 and 37 degrees C), Multivariate analysis identified HER2 overexpression as an independent unfavourable prognostic variable for adenocarcinomas as a whole and also for the hepatoid variant., HER2 mutations in lung adenocarcinoma predominantly occurred in women and never smokers., SLP-2 and HER2/neu can play a role in lymph node/distant metastases of breast cancers, Report role of systems biology in identifying drug targets and biomarkers of ErbB2/3-mediated drug resistance in ovarian neoplasms., the discordant HER2 amplification observed in metastatic gastric carcinoma lesions is explained substantially by heterogeneity within primary tumours., Report remarkable response rate in trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in HER2 positive stage II/III breast cancer., aberrant HER2 protein expression in carcinoma in situ seems to be more commonly associated with polysomy than with gene amplification., novel 5-alkynyl-4-anilinopyrimidines are potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases, ErbB2 overexpression is associated with chemoradiation resistance in muscle-invasive bladder cancer., This is the first report of a positive response to trastuzumab in a patient with HER2-overexpressing metastatic gastric cancer that was accompanied by bone marrow involvement and severe thrombocytopenia., In response to ErbB2 activation, the biosynthesis and secretion of soluble interleukin-1 receptor-like 1 (sST2) were increased. sST2-blocking antibodies reduced ErbB2-induced motility., patients with HER2-overexpressing locally advanced breast cancer show a more limited tumor-related immune suppression., Serum HER2/ECD concentration of >/=7.7 ng/ml has possible diagnostic value in stage I and II breast cancer. It should not be used as a determinant of HER2 positivity., There was a significant correlation between serum HER2 ECD levels and HER2 tissue status (P < 0.001, R = 0.36)., The decreased Th/Tr cells ratio indicates impaired immune function, suggesting that the stage IV breast cancer and the Her-2/VEGF-positive breast cancer patients have lower immune function., Invasive ductal mammary carcinoma type was analyzed for comparative investigation of hormonal receptors (estrogen receptor ER and progesterone receptor PR) and Her2/neu oncoprotein expression., The HER2/neu supraexpression was encountered in 58/156., Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser(703)-phosphorylation of Na(+)/H(+) exchanger NHE1., in breast cancer patents, HER-2/neu amplification was found to be significantly associated with increased risk of death; findings support a negative prognostic role for HER-2/neu in breast-cancer survival, a gene expression signature based on the HER2/EGF-activated transcriptional program can predict poorer prognosis of a subgroup of HER2-overexpressing patients., Amplification of HER2 and deletion of TOP2A were frequently observed in tumors with a high ploidy level., HER2-positive breast cancer patients given pertuzumab and trastuzumab plus docetaxel had significantly improved pathological complete response rate compared with those given trastuzumab plus docetaxel, without substantial differences in tolerability., and increased gene copy number of EGFR and HER2 characterize high-grade malignancy with unfavorable prognosis in salivary gland cancer, Suggest that responses to preoperative chemotherapy, including trastuzumab, are biologically driven and that a specific nomogram or predictor for HER2-positive patients has to be developed., No significant correlations were observed between the clinicopathological variables and PIK3CA, PTEN, and pHER2 status in breast cnacer., Case Report, HER2 seems to be a valid therapeutic target of EGFR inhibitors in HER2-addicted lung carcinomas, analysis of HER2 overexpression in non-small cell lung cancer, Protein interactions with HER2 can have different characteristics depending on the hosting cell line., Negative/low HER2 expression alone or combined with E-cadherin positivity is predictive of better prognosis in Tunisian patients with breast carcinoma., Data indicate that MET-mediated resistance to lapatinib is a novel mechanism of resistance to HER2-targeted agents in gastric cancer cells., This study confirms the favorable prognostic value of HER2/TOP2A co-amplification., Findings show that the bispecific antibody MM-111 forms a trimeric complex with ErbB2 and ErbB3, effectively inhibiting ErbB3 signaling and showing antitumor activity in preclinical models that is dependent on ErbB2 overexpression., esophageal adenocarcinomas with Barrett esophagus had nearly twice the odds of being HER2 positive and, within this subgroup, HER2 positivity was independently associated with improved survival., Data suggest that iIn gastric cancer, HER2 gene amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases., Consider it appropriate to evaluate HER2 expression using gastric cancer biopsy specimens., Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination., The findings uncovered an unexpected link between PGC-1a-mediated nutrient availability, unfolded protein response, and ErbB2/Neu levels., HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy predicts early disease recurrence and cancer-specific and overall mortality., Data show that EphrinB1, a PTPN13 substrate, interacts with ErbB2, and Src kinase mediates EphrinB1 phosphorylation and subsequent MAP Kinase signaling., HER-2/neu and TOPIIa are over expressed in gastric tumors and may promote disease progression., ER/PR and HER2 statuses between primary and liver metastatic lesions of breast carcinoma can be modified after treatment but are stable in most cases during the natural metastatic process., Signaling via the HER2/HER3 pathway in breast carcinoma cell lines may lead to enhanced natural killer cell (NKG2D)-histocompatibility class I-related chains A/B (MICA/B) recognition by NK cells and T cells., Data indicate that 266 (76.2%) tumors harbored EGFR mutations, 16 (4.6%) HER2 mutations, 15 (4.3%) EML4-ALK fusions, 7 (2.0%) KRAS mutations, and 2 (0.6%) BRAF mutations., Mutations in the kinase domain of HER2 is associated with treatment response in lung adenocarcinoma., 29 out of 83 (35%) samples tested by dPCR and 28 out of 86 (32.5%) samples tested by real time PCR have HER-2/neu gene amplification., Immunoreactivity for erbB1 was strong and that for erbB2 and 3 was moderate, while that for erbB4 was faint in nasal mucosa chronic rhinitis., HER-2 is stably expressed in primary gastric cancer and metastatic lymph nodes. HER-2 and leptin play an important role in the progression and angiogenesis of gastric cancer, The expression of Survivin in combination with BCRP and HER-2 is associated with clinical response to TE neoadjuvant chemotherapy in breast cancer., AEG-1 might facilitate the proliferation and invasion of breast cancer cells by upregulating HER2/neu expression., HER2 and CK20 were seen exclusively in the mucinogenic proliferations in congenital pulmonary airway malformations., This study shows a very high frequency of HER2 overexpression in breast cancers in patients with anti-Yo-associated paraneoplastic cerebellar degeneration., Women with a HER2/neu/neu+/Ki67+ ductal carcinoma in situ (DCIS) have a higher risk of developing DCIS local recurrence after breast-conserving surgery., c-erbB2 oncogene expression is a valuable marker in the differential diagnosis and prognostic evaluation of patients with intraductal proliferative lesions., HER2 overexpression is associated with recurrence in breast cancer., ErbB-2 overexpression in human breast cancer cell lines leads to phosphorylation & activation of Plexin-B1. This was required for ErbB-2-dependent activation of RhoA & RhoC & promoted invasive behavior., linkage between NRF2 and ErbB2 was confirmed in the ErbB2-positive breast cancer cell line BT-474, intratumoral heterogeneity of HER2 gene amplification is present in a subset of HER2-amplified breast cancers, ErbB2 and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells, EGFR overexpression relates to triple negative profile (ER-/PR-/HER2-) and poor prognosis in breast cancer patients in Tunisia, ERBB2 overexpression triggers transient high mechanoactivity of breast tumor., HER2 expression was less frequent in resectable gastric cancer than in metastatic gastric cancer; the impact of HER2 expression on survival was limited, HER2-negative (1+) breast cancer with unfavorable prognostic features., Addition of sorafenib to capecitabine improved progression-free survival in patients with HER2-negative advanced breast cancer., 68.3% of patients were ER-positive, and 71.5% were PR-positive. Among the 28.3% of HER2-positive tumors, the majority (19.2%) stained +++. Almost 50% of the tumors were ER+ PR+ HER2-, which makes this the predominant tumor type., These findings indicate that in the absence of HER2 amplification, chromosome 17 centromere gains do not have a significant effect on HER2 protein expression., No significant difference was seen between grade I and grade II/III meningiomas, primary and recurrent tumors, and males and females from the point of view of HER2 expression., identified two dominant expression clusters corresponding to samples belonging to the ERBB2+ and ERBB2- groups of pheochromocytomas and functional paragangliomas, Focal HER2 gene amplification is more common in gastric carcinomas with no or low expression of HER2., Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2., Aberrantly expressed miR-125b contributes to HEC1B cells invasion partly through directly down-regulating ERBB2 protein expression in endometrioid endometrial cancer., Her2-tumor-initiating cells-enriched signature was specific to HER2(+), signaling network activates the transcription of cathepsin B gene via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of cathepsin B, The up-regulation of HER2 and B(1)R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis., This review focuses on mechanisms of intrinsic and/or acquired resistance to HER2-targeted therapies that have been identified in preclinical and clinical studies., HER2 GH and HER2-positive tumors have distinctly different impacts on the clinicopathologic features of tumors. HER2 GH tumors may be closer to HER2 non-amplified tumors in their biologic behavior and is different from that of HER2 gene-amplified tumors., Pretreatment of tumor cells with STAT3 specific inhibitors or knocking down of STAT3 by SiRNA makes the tumor cell more susceptible to apoptosis and dendritic cell mediated inhibition of both CD24 and HER-2/neu, Data indicate that C-erbB2 gene plays important roles in the carcinogenesis and development of colon cancer., Expression of pSTAT3 correlates with Her-2 status and CAIX expression and is associated with tumor progression and worse outcome in esophageal cancer, HER2 may play an important role in the progression of carcinoma ex pleomorphic adenoma, and that HER2 amplification may be an additional prognostic indicator of CXPA., 3, overexpression correlates with the urothelial carcinoma of the upper urinary tract stage but not with survival or recurrence, This study demonstrates the role of C-erbB2 in the pathogenesis of gallbladder cancer as a late event in north Indian population which is a igh prevalence region for gallbladder cancer., HER-2 gene amplification is associated with breast cancer., Letter/Case Report, Results show strong correlations between mRNA levels of PRA and PRB, protein levels of hormone receptors, HER/ErbB receptors and ligands network, and suggest that crosstalks between PR and the HER family are a hallmark of breast cancer growth., The nanoparticle effectively and significantly inhibited colony formation of the target cells and silenced the Her2 gene expression at 5 nM, Combinations of trastuzumab plus docetaxel-based regimens were well tolerated and effective in previously treated metastatic gastric cancer of Chinese patients with HER2 over-expression or gene amplification., Mutation of this amino acid led to increased ERBB receptor activation and upregulation of the ERBB3/PI3K/AKT signaling pathway, which was no longer responsive to MEK inhibition, data presented here demonstrate a reciprocal expression pattern between EGFR family members during keratinocyte maturation in the skin, and altered expression of EGFR and ErbB2 was identified in atopic dermatitis lesional skin as compared to healthy skin., the relationship between HER2/neu, breast cancer subtypes, and a number of novel targets located at the HER2/neu amplicon, This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma., Amplification of Her-2/neu and/or topoisomerase IIalpha is associated with poor overall survival in breast cancer., Report use of somatostatin receptor/Her2 immunohistochemical scoring schemes in gastroenteropancreatic neuroendocrine tumors., HER-2 copy number but not the HER-2/CEP-17 ratio determines taxane-containing chemotherapy sensitivity in locally advanced breast cancer., Overexpression of HER2 and pHER2 to be associated with a significant reduction in overall survival in early breast cancer., HER2 gene amplification is significantly associated with patient survival in gastric cancers., This study demonstrates that there is a cross-regulation network between FOXA1 and ErbB2 signaling that connects FOXA1 to some of the key signaling pathways in estrogen receptor-negativebreast cancer., Bgn inhibits the major properties of HER-2/neu-transformed cells, which is inversely modulated by the PKC signaling cascade., GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt., A population-based cancer registry study demonstrated that HER2-positive tumors account for a substantial proportion of mammographic screening failure., rs4919510, The combined inhibition of HER2 and EGFR induced overt, long-lasting tumor regression., Within the macro domain of mH2A1.2, a trinucleotide insertion (-EIS-) sequence not found in mH2A1.1 was essential for the interaction between HER-2 and mH2A1.2 as well as mH2A1.2-induced HER-2 expression and cell proliferation., The ratio of c-erbB-2 staining increased as the grade and stage increased in colorectal adenocarcinoma., A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers., Lack of c-erbB2 expression in oral leukoplakia suggested that it does not play a pathogenetic role in the early stages of carcinogenesis in this Indian population., HER-2 expression in immunohistochemistry has no prognostic significance in gastric cancer patients, human epidermal growth factor receptor 2 (HER2/neu) protein, a 185-kDa transmembrane tyrosine kinase receptor, is associated with tumor proliferation, migration, and differentiation, The HER2 proto-oncogene is located on chromosome 17q21 and encodes a 185-kDa transmembrane tyrosine kinase receptor, HER2 (also known as HER2/neu, ERBB2, p185), hormone receptor-negative breast carcinomas are undifferentiated and diagnosed at advanced stages and HER2 expression is not associated with overall survival, Report immunohistochemistry/in situ hybridization assay for determination of HER2 protein/gene in breast cancer sections., the up-regulation of the Pcdhbeta gene cluster as a mechanism for reduced her-2-mediated tumorigenesis resulting from GnT-V deletion., These data provide new insight into HER2 trafficking at the plasma membrane and the changes induced by polyclonal HER2-specific antibodies., STAT1 expression is upregulated by nuclear EGFR and HER2, and that STAT3 synergizes with the three receptors to further enhance STAT1 expression., Tethered conformation of unliganded ErbBs evolved to prevent crosstalk among ErbBs, and establish a molecular basis for both negative cooperativity of ligand binding to vertebrate ErbBs and the absence of active ErbB2/HER2 homodimers in normal conditions., Immunohistochemical study of adhesive molecules Her-2/neu in nonendometrial carcinoma of corpus uteri, Compared to the United States, low age standardized and age specific breast cancer incidence rates were found in Kurdish women; nevertheless, the proportional expression of HR and HER2 for both Kurds and Arabs was comparable to that of US white women., A-62176 is a dual inhibitor that impairs the expression of HER2., Higher order complexes of nonoverexpressed ERBB receptors are an integral and qualitatively distinct part of normal ERBB2/ERBB3 signaling., Lymph node ratio is a new feature for defining risk category of HER-2 node-positive breast cancer patients., HER2 may be related with the pathogenesis of NSCLC and act as an unfavorable prognostic factor in T1N0M0 and T2N0M0 NSCLC, especially in stages IB and IIA diseases., analysis of multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor, The frequency of HER2 overexpression in early onset breast cancer patients was 28.1%, with a higher proportion of whites with overexpression of HER2 at 34.1% compared with 22.9% and 25% for African-Americans and Asians., study concludes that JAM-A is co-expressed with HER2 and associates with aggressive breast cancer phenotypes; speculate that JAM-A may regulate HER2 proteasomal degradation and activity, Among the 139 HER2-positive cases, the relapse rate was associated with the intensity of stromal hyaluronan staining as most of the relapses occurred in the cases with intense stromal hyaluronan staining., Data indicate that regulatory T cells (T-regs) cell number of Her-2/neu-positive patients were higher than in samples from patients with hormone receptor positive, Her-2/neu-negative cancers., HER2 mutations identify a distinct subset of lung ADCs. Given the high prevalence of lung cancer worldwide and the availability of standard and investigational therapies targeting HER2, routine clinical genotyping of lung ADC should include HER2., The probe developed for RNA-ISH represents a viable, effective possible alternative to FISH and IHC for analysing HER2 status in primary breast tumours., ErbB2 amplification results in aberrant activation of cap-dependent mRNA translation in esophageal cancer cell lines., HER-2 receptors that can act as a starting point to trigger intracellular signaling pathways are strongly involved in the progression of cancer., The endosomal recycling of the ErbB2 and EGFR receptors is associated with efficient K63-polyubiquitination, but significantly decreased Hrs tyrosine phosphorylation as well as impaired deubiquitination by AMSH., Binding of L1CAM to erbB enhances its response to neuregulins., Quantifying HER2 expression and dimerization by TR-FRET assays might help identifying novel clinical markers for optimizing patients' treatment in oncology., Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer., ErbB2 is a direct substrate of PTPRO and decreased expression of PTPRO predicts poor prognosis for ErbB2-positive breast cancer patients., In ER-positive breast cancer, correlations were found in the expression of activated HER-receptors (pHER1, pHER2, pHER3), indicating a potential role of HER1 and HER3 in the activation of HER2. HER2 expression was associated with poor prognosis., the low number of patients in this study, genetic profile of the patient population, possible weight changes after treatment and the inverse relationship between body mass index and c-erbB2 expression., we describe how flotillin-1 and -2 contribute to the stabilization of ErbB2 at the cell surface in breast cancer tissue, MMP-9 significantly increased HER2/neu expression on the surface of human mammary epithelial cells., Her-2/neu-testing in breast cancer, Different Her-2 status in infiltrative and intraductal components of the breast cancer, There is early involvement of HER2 dysregulation (amplification and protein overexpression) in both gastric (intestinal-type) and Barrett's oncogenesis., Data suggest that HER-2 and leptin (but not leptin receptor) are up-regulated in gastric cancer and are associated with tumor invasiveness, lymphatic metastasis, and angiogenesis., Results show that elevated baseline sHER2 levels (>15 ng ml(1)) and a decrease of sHER2 levels (>20%) early after therapy initiation are both relevant criteria to predict response to lapatinib-based treatment., High-level ERBB2 amplification occurs in a small fraction of lung cancers with a strong propensity to high-grade adenocarcinomas., Propose that HER2 represents a reasonable target for molecular therapy in HER2- positive metastatic or recurrent mucinous ovarian carcinoma., c-erbB-2 overexpression may have a prognostic significance in patients with metastatic gastric cancer., High c-ErbB-2 expression is associated with ovarian cancer., These patients had significantly longer TTBM than those without anti-HER2 treatment., TNF-alpha treatment led to intracellular Her-2 cleavage via a caspase-8-dependent signaling pathway in MCF-7 cells defective for NFkappa B activation., study found no overexpression of HER2/neu in head and neck squamous cell carcinomas; findings suggested that the use of Her-2 as a salivary marker of head and neck squamous cell carcinoma cannot be recommended, The simultaneous gain of NUPR1 and ERBB2 can be a significant predictor of poor prognosis in early-stage breast cancers., study found that HER-2 2 /HER-2- tumors carry a prognosis that is worse than that of tumors with no or weak HER-2 expression, clinical data analyses revealed a strong correlation between CD151 and ErbB2 expression and metastasis-free survival of breast cancer patients., These results implicate HER2 as a novel protein involved in the sensitivity or resistance of EGFR-mutant lung cancer, MED1 is recruited to the HER2 gene and required for its expression., Patients with HER2(+) metastatic breast cancers have epithelial-to-mesenchymal transition-circulating tumor cells., positivity, but not HER2 positivity, was associated with poor patient outcomes after curative resection of stage II/III gastric cancer., intracellular domains play a crucial role in HER3's function as an allosteric activator and its role in downstream signaling, Downregulation of HER2 via siRNA resulted in a significant decrease in ERK phosphorylation and a 50% reduction in IL-8 secretion., inhibition of EGFR expression reduced HER2-induced anchorage-independent growth and tumorigenesis, Incorporation of this engineered Fc into trastuzumab, resulted in a 75% increase in tumor cell phagocytosis by macrophages compared to that of the parental glycosylated trastuzumab with both medium and low Her2-expressing cancer cells., Data indicate that the monoclonal antibodies were directed to extracellular domain of HER2., Levels of C-erbB-2, CXCR4 and ER-alpha in patients decreased after they received neo-adjuvant chemotherapy., Our findings demonstrate that HER2 and HER3 co-expression induces IL8 autocrine signaling, leading to the invasion of mammary cells., This could be an important mechanism leading to trastuzumab resistance in HER2-overexpressing breast cancer cells., The positive correlation between HER2- and CXCR4-expression was validated in esophageal cancer patients., HER2 transcription levels were found to be significantly related to pT class, pN class, and tumor recurrence. mRNA expression was well correlated with protein overexpression and gene amplification, Polymorphisms in the HER2 gene (Ile655Val) and an ATCTT insertion at intron 4 of PTEN, are associated with breast cancer susceptibility., A subset of high-grade non-muscle-invasive bladder cancers contain Her2 amplification and are associated with markedly aggressive behaviour., a profound activation of the EGFR system in breast cancer, HER2-mediated prosurvival signaling network is responsible for the aggressive phenotype of breast cancer stem cells., High ErbB2 expression is associated with breast cancer., Reflex HER2 immunohistochemistry testing after initially ambiguous HER2 FISH testing provides definitive HER2 status in a majority of cases (70%)., Plasma levels of HER2 extracellular domain predicts response to trastuzumab regimens in breast cancer., Chromogenic in situ hybridization could provide an accurate and practical alternative to fluorescence in situ hybridization for the clinical diagnosis of HER2 gene amplification., Breast cancer mRNA levels of ESR1 and HER2 predict response to neoadjuvant chemotherapy and are significantly associated with long-term outcome., Results suggest a possible participation of erbB1-4 and claudin-1 in tissue remodelling in chronic hypertrophic rhinitis., Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer., These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation., Data show that HER2 gene copy by quantitative PCR on tissue correlated well with those by FISH technique, but plasma HER2 level was not., ErbB2 levels inversely impact cell clathrin-mediated endocytosis capacity in breast cancer cells treated with geldanamycin., Data indicate that the concordance between HER2 status of the paired samples by local immunohistochemistry testing and central in-situ hybridization were 78% and 99%, respectively., together, our results suggest that c-myc, p53, C-erbB-2 and COX-2 proteins do not correlate with cancer stage or follow-up in Esophageal squamous cell carcinoma, HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage., Amplification of the ERBB2 gene in breast tumors is potentially initiated by a complex region that has unusual genomic features., Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels., The level of HER-2/neu mRNA was higher and RECK mRNA was lower in breast carcinoma than homologous paraneoplastic breast tissue., Twenty-seven point five percent of oesophageal adenocarcinomas showed evidence of HER2 over expression., The present study revealed that ESCC of Brazilian patients do not present mutations in hot spots of EGFR, K-RAS and BRAF and only a minor proportion present overexpression of EGFR or HER2., LC combination therapy was effective and well-tolerated in patients with HER2+ MBC with BMs, who had progressive disease after trastuzumab-containing therapy., Double HER2 blockade is an effective therapy in disseminated CDC even in the presence of brain metastases., analysis of the GP2 peptide of HER2 by terahertz spectroscopy, ERBB1 and ERBB2 have different roles in response to antineoplastic agents in colorectal cancer cells, The results demonstrated that EGF bound to EGFR more stably in the cells co-expressing EGFR and HER2, and the binding enhancement in the presence of HER2 was inhibited by either Trastuzumab or Pertuzumab, EGFR and Her2 were significantly upregulated in lymph node metastasized colorectal cancer (LNM CRC) compared to non-LNM CRC., Results suggest that patients with HER2 mutation-positive breast cancers could benefit from existing HER2-targeted drugs., HER2 examination on fluorescence in situ hybridization using fine-needle aspiration cytology samples of tumors in recurrent/metastatic sites or disseminated tumor cells in effusion is beneficial, localizes in mitochondria of cancer cells and negatively regulates mitochondrial respiratory functions, HER2 status is not an independent prognostic biomarker in early oesophago-gastric adenocarcinoma., The major effect of EBP1 on ErbB2 mRNA expression levels is at the transcriptional level., Findings suggest that autocrine motility factor (AMF)-HER2 interaction might be a novel target for therapeutic management of patients with breast cancer, whose disease is resistant to trastuzumab., HER-2/neu overexpression/amplification is associated with gastric cancer., Silencing of HER2 caused a greater growth arrest and apoptosis in trastuzumab responding compared to the non-responding cell lines, indicating that the resistant cells are inherently less dependent on the HER2 pathway., antierbB2 scFvFcIL2 fusion protein significantly delayed HER2 overexpression of nonsmall cell lung cancer (Calu3) in human nonsmall cell lung cancer xenografts in nude mice, HER2 induces transcriptional activation of leptin in MCF10A human breast epithelial cells., Fcab clones that retained their affinity to Her2/neu but exhibited a significantly increased conformational stability and resistance to aggregation could be evolved, The proposed enhanced method substantially improves HER2 FISH assessment in breast cancer biopsy specimens because the evaluation of HER2/CEP17 copy numbers is more representative, easier, and faster than the conventional method., Expression levels of ERBB2, caveolin-1 and DNA-PKcs were increased., High HER2 expression is associated with gastric carcinomas with advanced stages., Newly developed ovarian serous adenocarcinoma cell line, TU-OS-4 overexpresses human her2 protein., There was no statistically significant association between histopathological parameters and Her-2 gene polymorphism/expression in patients with gastric cancer, Her-2 expression in circulating tumor cells varied greatly within and among patients compared with Her-2 expression in leukocytes. Her-2 expression is heterogeneous among circulating tumor cells within each patient., an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate, The positive rate of vasculogenic mimicry in invasive breast carcinoma correlated with the increased HER2 expression., HER-2 amplification is detectable in a relevant proportion (26.7%) of rectal cancer patients., we show that the expression of p95HER2 in breast epithelial cell lines results in either increased proliferation or senescence., Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition., HER-2 functions as an oncogene in SKOV3 human ovarian carcinoma cells., The results suggest that miR-199b-5p may have the potential to be a novel important alternative therapeutic target for HER2-positive breast cancer., WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic breast cancer tumours devoid of ERalpha, PR and HER2 expression., ATG12 is a novel determinant of breast cancer primary resistance to HER1/2-targeted therapeutics., irradiation induces HER-2/neu gene amplification and CEP17 polysomy thereby enhancing expression of this protein in breast cancer cell lines rendering them susceptible to treatment with trastuzumab, Thirty of 344 patients (9%) whose tumors were initially HER2-negative were found by FISH to have supernumerary HER2 gene copies (up to 15 copies) after neoadjuvant chemotherapy., Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis., these data show that ionizing radiation-mediated activation of ErbB2 and induction of 14-3-3zeta collaborate to regulate FoxM1 and promote invasion of breast cancer cells, HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage., HER2 exon 20 mutation is associated with non-small-cell lung cancer., Polymorphic HER2 variant alanine allele carries higher frequency in Parkinson's disease patients, linking the Parkinson's and HER2 polymorphism and suggesting an effect of the C-terminal domain of HER2 in dopaminergic cell survival., The present data suggest that ErbB2, ErbB3, and ErbB4 genes may have a role in bladder cancer tumorigenesis., HER-2 positivity and gene amplification are fairly frequent and independently associated with poor survival in esophageal adenocarcinoma, TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer., Report c-ERBB-2 mutations in pancreatic ductal carcinoma and their relationship to patient survival., Our preliminary data demonstrate score 3+ staining for ErbB2 in 10% of adamantinomatous craniopharyngiomas and different localization of 3+ ErbB2 cells and cells with nuclear beta-catenin immunoreactivity., HER2 gene copy number status is asociated with clinical efficacy in metastatic colorectal cancer, Heterogeneous HER2 expression in primary gastric tumors and the variable lymph node metastasis status suggest evaluating multiple samples., These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer., In breast cancer, dual in situ hybrid-ization may underestimate the HER2/chromosome 17 ratio, or fluorescence in situ hybridization may overestimate this ratio., There was no statistically significant correlation between histopathologic grading of salivary gland mucoepidermoid carcinoma and c-erbB-2 expression., racially restricted contributions of GM and FcgammaR genotypes to humoral immunity to HER2, Report nuclei-based classifier as a tool for automated quantitative HER2 FISH signals analysis in nuclei in breast cancer specimens., ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways., Response to trastuzumab is correlated to HER2 mRNA levels only in ESR1-positive tumors. This study adds further evidence to the different biology of both subsets within the HER2-positive group., These findings are very important for understanding the occurrence, development, prognosis and treatment of breast cancer in Chinese population., Our study suggested that ER/PR status and histological grade are risk factors for the development of bone metastasis in breast cancer patients., Data suggest that ErbB receptors (ERBB2, ERBB3, and ERBB4) are expressed in most endometrial cancers; expression of ErbB receptors appears to be related to poor prognosis; dismal outcomes correlate with cancers positive for all three ErbB receptors., The rate of cases overexpressing Her2 in advanced gastric adenocarcinoma in our study (35.5%) is higher than that observed in most series in the literature, our results suggest that the detection of ESR1/PGR/ERBB2 mRNA levels by RT-QPCR is a better approach for subtyping breast cancer and predicting the prognosis., HER2 is overexpressed in 13% to 20% of NSCLCs (with 3+ expression in only 2% to 6%). HER2 insertions have been found to induce constitutive activation of the HER2 kinase in a ligand-independent fashion., High HER2 expression is associated with lung adenocarcinoma-associated cytologically negative pleural effusions., Eag1 K+ channel and ErbB were expressed in all human pituitary adenomas examined while ErbB2 expression was more variable., Quantitative HER2 determination by Centaur did not define a new group of patients eligible for HER2-targeted therapy., FAS and HER2 overexpression are common in esophageal carcinomas, our data indicate that the ERBB2 gene is a novel MBP-1 target, and analysis of primary tumors suggests that the concomitant high expression of MBP-1 and HDAC1 may be considered a diagnostic marker of cancer progression for breast IDC., Latest advances in HER2/neu status diagnostic assessment and the most relevant research emerging from "Omics" (genomics, epigenetics, transcriptomics, and proteomics) studies on HER2/neu-positive breast cancer. Review., These data suggest that HER2/Akt is an important negative regulator of p57 (Kip2), and that p57 restoration in HER2-overexpressing cells can reduce breast tumor growth., Simultaneous overexpression of CD44 and c-erb-B2 may be used as a marker of poor prognosis in gastric carcinoma., we show that HER2 is selectively expressed in and regulates self-renewal of the cancer stem cell (CSC) population in estrogen receptor-positive (ER(+)), HER2(-) luminal breast cancers., HER2 amplification was a rare event (1.9%) in squamous cell carcinomas of the vulva., interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells., HER-2/neu induced the improvement of autocrine estrogen in endometrial carcinoma cell through triggering the COX-2/P450arom signal., HER2 overexpression was associated with an increasing risk of developing metastases., PTEN, VEGF, HER2, p53 expressions were compared with bevacizumab response., These results suggest that highly malignant differentiated thyroid cancer can be detected by monitoring HER2 status and telomere shortening, and that trastuzumab therapy may be effective for refractory thyroid cancer., The study aimed at examining the relationship between HER2 immunohistochemistry assessment scores in paired core needle biopsies and whole tissue sections of invasive ductal breast carcinoma., Data indicate that EGFR T790M as the most common mechanism of acquired resistance, whereas MET amplification, HER2 amplification, and small cell histologic transformation occur less frequently., The level of HER2/neu amplification tends to increase from the primary tumour to the paired metastases in a significant proportion of patients with HER2-positive metastatic breast neoplasms., Topo IIalpha, together with HER-2, might help to select for patients who could benefit from anthracycline-based neoadjuvant chemotherapy and identify non-complete responders at a higher risk of disease recurrence or death., results indicate that specific amplified and/ or overexpressed genes found in ERBB2-amplified breast cancer may mediate response to ERBB2-targeting agents, Results indicate that neither total cfDNA nor HER2 gene copy number is elevated in primary breast cancer patients, and the level of both parameters increased during neoadjuvant chemotherapy, but without any relation to treatment effect., an NRG1-ERBB3-ERBB2 signaling unit operates in melanoma cells where it promotes growth and survival., Data indicate that monitoring tissue HER-2-positive breast cancer patients with serum HER-2 has a sufficient sensitivity to detect metastatic recurrence, while its use in monitoring of tissue HER-2-negative patients is unsatisfactory., Nucleophosmin/B23 is a favorable prognostic indicator for gastric cancer, but Her-2/neu has no relationship with prognosis., completely human, functionalized GrB construct can effectively target Her2/neu-expressing cells and displays impressive in vitro and in vivo activity., HER2-positive disseminated tumor cells in early breast cancer patients is associated with an increased risk of relapse., the suppressive role of Necl-2 in the HRG-induced ErbB2/ErbB3 signaling is regulated by miR-199a at least through the reduction of the ST6GAL1-catalyzed sialylation of Necl-2, EpCAM expression was associated with an unfavourable prognosis in the basal-like and luminal B HER2(+) subtypes but associated with a favourable prognosis in the HER2 subtype breast cancer., Her-2/neu over-expression and parameters assessing metastatic burden in the SLN, particularly total metastatic area (TMA), predicted the presence of NSLN involvement and extranodal disease in patients with breast carcinoma and SLN metastases., A significant association between HER2 amplification and treatment with respect to both disease-free survival and overall survival in gastrointestinal adenocarcinoma., Immunostain of Her2/neu has been positive in 42.2% of cases, the poorly differentiated carcinomas presenting high scores regardless of tumor stage., The her2 receptor attachment function of measles virus hemagglutinin is not required for its fusion-helper function., these results suggest that coupling HDAC and HER2 inhibitory activities to an EGFR inhibitor may potentially be effective in overcoming drug resistance and preventing cancer cell migration, HER2 mediates the effects of epidermal growth factor (EGF) on Snail, Slug and E-cadherin expression as well as on ovarian cancer cell invasion., Data suggest that p63/Her2/neu expressing precursor intermediate in comedo-DCIS may provide a cellular basis for emergence of p63+/Her2/neu- or p63+/Her2/neu+ basal-like breast cancer., BMs were detected very rarely in asymptomatic, non-metastatic HER2-positive breast cancer patients compared with asymptomatic, metastatic patients., A positive correlation was demonstrated between lymphocyte infiltration and HER2 gene amplification in breast cancer., newly identified HER2 epitopes seem to be crucial for an effective immune response against HER2-overexpressing breast cancers and might help discriminating between metastatic breast cancer and early breast cancer, Studies indicate that epidermal growth factor-2 (HER2) overexpression occurs in many other tumor types, including esophageal cancer., Data indicate that genomic profiling of relapsed CDH1-mutated invasive lobular carcinoma (ILC) featured a high incidence of ERBB2 alterations., Data indicate a signaling pathway from ErbB2 to p21-Activated kinase-1 (Pak1) to beta-catenin that is required for efficient transformation of mammary epithelial cells., Her2/neu alterations may occur early and increasingly during Barrett's malignant progression., DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis., HER2 655V polymorphism is potential risk factor for development of breast cancer., Report HER2 gene amplification and protein expression in Chinese patients with resectable gastric cancer and the association with clinicopathological characteristics and survival., This study demonistrated that Her2neu amplification associates with Co-deletion 1p/14q in recurrent meningiomas., This study of patients presenting with HER2-mutated non-small-cell lung cancer, were found to be mainly female, nonsmokers, and exclusively suffering from adenocarcinoma subtype disease., results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly, These results confirm that the outcome of HER2-positive patients treated with trastuzumab is significantly worse in patients with PIK3CA-mutated compared with wild-type tumours., the acquired substrate preference for GAB1 is critical for the ERBB2 mutant-induced oncogenesis., No statistically significant correlation between trastuzumab resistance and the expression of HER2 was noted in breast cancer., Metformin can inhibit the proliferation and promote apoptosis of HER2 positive breast cancer cells,which is maybe related to inhibition of HSP90., Report changes in HER2 expression in breast neoplasms after neoadjuvant dose-dense doxorubicin, cyclophosphamide followed by paclitaxel., Moderate overexpression of HER-2/neu was detected in a small proportion of colorectal cancer patients., Dysregulation of miR-125a-5p/125b and HER2 is an early event in the gastric (intestinal-type) and esophageal (Barrett) oncogenesis., The clinicopathological factors and incidence of HER2 expression of Mucinous epithelial ovarian cancer in a large Asian retrospective cohort from Singapore, is reported., a proportion of patients with breast cancer harbor tumor cells in blood and/or bone marrow, and the HER2 status of these residual tumor cells can be different from that of the primary tumor., MUC1 and HER2 might be closely associated with invasive phenotype of intraductal papillary mucinous neoplasm., Analysis of plasma DNA with digital PCR has the potential to screen for the acquisition of HER2 amplification in metastatic breast cancer., Approximately 10% of Chinese patients with primary gastric cancer (GC) and gastroesophageal junction (GEJ)adenocarcinoma were HER2-positive on immunohistochemistry., a positive correlation exists between flotillin2 and erbB2 expression levels, TPD52 is a survival factor in ERBB2-amplified breast cancer., we found that HER2 or GCDFP15 protein overexpression is a sensitive and specific tool to differentiate MA from BL in the context of ER negative tumors., Two independent high-risk primary breast cancer subgroups for developing brain metastases were identified, represented by genetic alterations in either HER2 or EGFR/PTEN-driven pathways., Data suggest that up-regulation of signaling via ERBB2 and EGFR (epidermal growth factor receptor) by leptin contributes to vascular dysfunction (as seen in obesity, metabolic syndrome, and diabetes). [REVIEW], Serum HER 2 extracellular domain level is correlated with tissue HER 2 status in metastatic gastric or gastro-oesophageal junction adenocarcinoma, Altogether the results indicate that pertuzumab can be a valuable therapeutic agent not only in cancers overexpressing ErbB2 but also in cancers co-expressing ErbB2 and ErbB3., overexpressed in a subset of pancreatic ductal adenocarcinomas, no association with survival, HER2 protein expression and HER2 gene amplification are infrequent in small intestinal carcinomas., Findings suggest an association between lapatinib-induced autophagy and the disruption of Her2-Beclin-1 complex., HER2 inhibited calpain-1 activity through upregulating calpastatin, an endogenous calpain inhibitor., The patients homozygous for the Valine allele showed strong HER2 protein expression. The results showed that the valine allele may be an indicator of genetic susceptibility to ovarian carcinoma, Data suggest that ssessment of Her-2 expression status may be valuable for the targeted therapeutic management of colorectal cancer (CRC)., Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability., This study confirms that discordance in ER and PR receptor expression between the primary breast tumor and the corresponding metastatic lesions is high, whereas HER2 status remains relatively constant., A downregulation of FASN effectively inhibits the activity of "HER2-PI3K/Akt axis" and alters the malignant phenotype in colorectal cancer cells., CDC25a is a target of HER2 signaling in human breast cancer., Review discusses the clinical significance of HER2 discordance in breast cancer., DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (ERB2) of which 62% are hypermethylated., Studies suggest that the efficacy of HER2 targeting agents may be related to their ability to target the breast cancer stem cell (CSC) population., HER2 mutation was present in one male, non-smoking patient with low differentiated adenocarcinoma (0.67% of all patients with brain metastases from Non-small cell lung cancer and 1.5% of patients with adenocarcinoma)., Data suggest that detection of ductal carcinoma in situ (DCIS) based on marker expression during breast conserving surgery should be possible with a panel of molecular imaging tracers targeting CD44v6, GLUT1, HER2, IGF1-R, and EGFR., HER2 over-expression in gastric adenocarcinoma of Chinese patients was significantly more common in proximal than in distal cancers., Lower expression level of HER2 and high expression levels of phosphorylated HER2 is associated with breast cancer., positive expression of phosphorylated pHER2 may yield additional information regarding the poor prognosis of breast cancer and could be used for pre-selection of patients with HER2-overexpressing breast cancer displaying resistance to trastuzumab treatment, heavy alcohol use during the course of trastuzumab treatment for breast cancer and the HER2 Ile/Val genotype may constitute risk factors for cardiac toxicity, Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival, and Her-2 status shows a valuable correlation with clinical parameters., ER, PR, and HER2 expression in the biopsy and final pathology are still needed for selecting patients for postoperative adjuvant treatment in clinical practice., After 3.5 years follow-up, we failed to show that 6 months of treatment with trastuzumab was non-inferior to 12 months of trastuzumab. Despite the higher rates of cardiac events, 12 months of adjuvant trastuzmab should remain the standard of care., in this largest comprehensive study, 35% of endometrial serous carcinoma harbors HER2 protein overexpression and/or gene amplification., Androgen blockade decreases serum PSA by eliminating HER-2 negative prostate cancer cells., Dual staining technique which allows simultaneous detection of myoepithelial marker protein and cancerous HER2 gene is feasible., HER2-I655V polymorphism is associated to a left ventricular ejection fraction <50 % during adjuvant trastuzumab treatment of breast cancer patients., The CD151 complex has a critical regulatory role in ErbB2-dependent signaling., Increased HER2 expression is associated with cervical clear cell carcinoma., Lapatinib inhibited the proliferation and the rate of DNA synthesis in HER2-positive cells, Assessed the HER2 status in gastric cancer tissue microarrays and corresponding whole sections using HercepTest immunohistochemistry (IHC), and to correlate it and to assess the concordance of HER2 IHC and fluorescence in situ hybridization in TMAs., Results show that methylation of histone methylation mark H3K9 can be induced and this epigenetic mark was instructive in promoting downregulation of HER2/neu expression., Report prognostic value of HER-2 determination in fine needle aspirates of breast tumors., Immunohistochemical expression of HER-2 was not associated with characteristics of invasive breast cancers., HER-2 levels were altered after neoadjuvant chemotherapy in breast cancer., In gastric adenocarcinoma, Her-2/neu, as a marker of long time survival prediction, seems to be limited., findings show that a significant percentage of breast tumors coexpress MET and ERBB2; ERBB2(+) breast cancers with MET(+)/ERBB2(+) subpopulations may have an innate resistance to ERBB2 inhibition, EGFR, but not ERBB2, is expressed in precursor lesions of squamous cervical neoplasia and is related to the neoplastic progression, P130Cas overexpression synergizes with ErbB2 in mammary cell transformation and promotes ErbB2-dependent invasion., HER2 receptor expression is detectable by immunohistochemistry in approximately 20% of non-small cell lung cancers and in 2% of NSCLC using gene amplification by FISH. HER2 is activated by axon 20 in frame insertion mutations in 2% of lung adenocarcinomas, literature review comprises immunohistochemical studies on the clinical significance of c-erbB2/HER2 overexpression in gliomas, medulloblastomas, and meningiomas, Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface., Data show that the inactive conformation of ERBB2 does not interact with HSP90 chaperone., Results show that scFvs against HER-2/neu and carcinoembryonic antigen (CEA) were isolated., proteomic analysis of HER2 in breast cancer cells reveals proteomic changes triggered by the amplification of this single gene, and the downstream biological changes triggered by HER2 overexpression, HER2 gene amplification and an increased EGFR gene copy number (with balanced chromosome 7 high-polysomy) were each detected in four of 28 (14.3%) salivary mucoepidermoid carcinomas., we demonstrated the prognostic value in the various disease subtypes, including HER-2-positive disease irrespective of therapy., Findings suggest that aluminum concentration does not affect genomic stability of ERBB2, C-MYC, and CCND1 genes in breast tissues., Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2., Expression of Delta-HER2 induces tumor formation and metastasis., This meta-analysis result suggested that EGFR or HER2 should have significant predictive ability for estimating overall survival in GC patients and may be useful for defining prognosis of GC patients., In HER2-positive gastric cancer., HER-2/neu overexpression was not associated with a significant impact on survival., The correlation of Her2 expression with the expression of Her2 chaperoning HSP90 may indicate a synergistic regulation., report results from long-timescale molecular dynamics simulations indicating that a single ligand is necessary and sufficient to stabilize the ectodomain interface of Her2 heterodimers, which assume an asymmetric conformation similar to dEGFR dimers, Uterine serous carcinoma cell lines exhibiting HER2 gene amplification were significantly more sensitive to GDC-0980 exposure., Variability in HER2 staining in HER2-positive tumours has no role in clinical management with adjuvant trastuzumab, Findings support the development of CDK and Raf co-targeting strategies in EGFR/HER-2-overexpressing or RAS/RAF mutant breast cancer (BC)., Both FGF1 and ERBB2 significantly influenced overall survival in breast cancer patients, especially among women with low levels of Native American ancestry., Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro., The frequencies of EGFR, KRAS, BRAF, and HER-2 mutations in BM-NSCLC were 2.6, 38.5, 0, and 0% respectively., Myocardial strain imaging is more sensitive than left ventricular ejection fraction for the early detection and intermediate term monitoring of LV systolic function following anthracycline chemotherapy in HER2/neu negative breast cancer patients., HER-2 alteration is not an independent prognostic factor for curatively resectable gastric cancer, LOXL2 expression in normal epithelial cells can induce abnormal changes that resemble oncogenic transformation and cancer progression., Pertuzumab, a novel HER2 dimerization inhibitor, has been shown to be effective in the treatment of metastatic HER2-positive breast cancer--{REVIEW}, constructed an integrated mathematical model of HER activation and trafficking. Studied HER phosphorylation and abundance data collected in a panel of human mammary epithelial cells expressing varying levels of EGFR/HER1, HER2 and HER3., Data indicate that all mesenchymal colony clusters displayed a predominant CD44+/CD24- phenotype with decreased HER-2 expression and elevated levels of a beta1-integrin isoform with a high degree of N-glycosylation., In tumours from postmenopausal women harbouring normal HER2 gene copy numbers, we found HER2 and HER4, but HER3 levels in particular, to be elevated compared to controls, Patients with HER2 loss tend to have a higher risk of relapse compared with maintained HER2 positivity in breast cancer., all pairings of the EGF receptor, ErbB2, and ErbB3 form ligand-independent dimers/oligomers., HER2 as a promising target for cytotoxicity T cells in human melanoma therapy., HER2 expression was found in 10% of tumors and was related to only one histological type of tumor - salivary duct carcinoma., In contrast to the higher incidence reported at the population level, 20-30% HER2-positive cases for metastatic carcinomas, and only 11% of the screen-detected breast carcinomas displayed HER2/neu gene amplification, The suitable cut-off value for p53 overexpression was determined to be 50%, and p53 overexpression appears to be a significant prognostic factor in patients with luminal/HER2-negative breast cancer, CREB plays an important role in the HER-2/neu-mediated transformation by altering in vitro and in vivo growth characteristics., presence of cyclin E isoforms in p53 silenced clones also does not altered HER-2 expression, Quantitative assessment of intratumoral HER2 heterogeneity may offer an opportunity to improve the identification of patients likely to respond to HER2-targeted therapies., HER2 overexpression is associated with an immune escape phenotype. [review], MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells., An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models., Data show that peptide-pulsed dendritic cells (DCs) prime naive CD8-positive (+) T cells to exert HER-2/neu peptide-specific cytotoxicity and CD4+ T cells to proliferate in a peptide-dependent manner., HER2 and MYC are frequently coamplified in breast cancer, associated with aggressive clinical behaviour and poor outcome., ErbB2 expression is inversely associated with recurrence in urothelial tumors of the upper urinary tract., An isogenic gene expression signature was identified between triple-negative and HER2-positive breast cancers., Specific cytolytic activity of retargeted T cells to kill HER2 positive SKBR3 cell., PTPRO methylation is associated with poor survival only in HER2-positive patients., Crystal structure of the human HER2 receptor in complex with a duplex DARPin inhibitor., Combined HER2-targeted therapy produced a numerically but insignificantly higher pathological complete response percentage than single-agent HER2-directed therapy., The specific binding of the RNA aptamer to the HER2 receptor., Breast cancer with a HER2 positive subtype is associated with the longest survival after diagnosis of distant metastases., In spite of a 52-week adjuvant trastuzumab treatment, classic poor prognostic factors for invasive EBC remained as such in patients with HER2-positive EBC., Consensus scoring of breast carcinomas for HER-2 immunohistochemistry by experienced pathologists is likely to decrease the use of fluorescent in situ hybridisation testing., HRG1 mediates resistance to lapatinib through HER3 and AKT activation, and this depends on residual HER2 activity., our data indicate that ErbB2 activation promotes GLS1 expression via a PI3K-Akt-independent NF-kappaB pathway in breast cancer cells, identifying another oncogenic signaling pathway which stimulates GLS1 expression, In cases with cluster amplification, HER2 protein overexpression by immunohistochemistry closely correlated at the cellular level with HER2/NEU gene amplification., HSP90 inhibitor was more efficacious in HER2-positive tumors than in HER2-negative tumors., Data indicate that a mean HER2/CEP17 ratio of 4.7 was identified as the optimal cutoff value discriminating sensitive and refractory patients., Although up to 30% of non-small-cell lung cancer cases display HER2 overexpression, amplification or mutation, the prognostic significance of HER2 dysregulation remains undefined, Ligand stimulation of non-overexpressed ERBB2 transiently removes UCP2 and paradoxically reduces the mitochondrial membrane potential, oxygen consumption, and OXPHOS on a signaling time scale., Investigated ERBB2 expression and invasiveness of glioma cells. ERBB2 shRNA transfection vector could effectively inhibit expression of ERBB2; while ERBB2 overexpressing vector transfection could significantly improve expression of ERBB2 in TJ905 cells., HER2 expression is not associated with a difference in the treatment outcome in patients with rectal adenocarcinoma., Seven novel microRNAs, direct HER2 regulators were identified. miR-342-5p was associated with better survival in breast cancer patients., The use of the 4B5 antibody on whole-tissue sections was the most accurate immunohistochemical method for evaluating HER2 expression in gastric adenocarcinoma., Data indicate that HER2 positive was an independent adverse prognostic factor in group B patients without trastuzumab and group C patients of HER2-negative without trastuzumab., siRNA cocktail, and co-downregulation of VEGF and HER2 result in significant inhibition of gastric cancer growth and migration in vitro, marker of main subtypes of invasive breast cancer in China, TFF3 expression at both mRNA and protein levels was significantly downregulated by ErbB-2 silencing in breast cancer cell lines, investigation of STAT3 tyrosine-705 phosphorylation and its correlation with its possible regulator HER2 in the prognosis of pancreatic ductal carcinoma, Different HER2 mRNA profiles, possibly in relation to contact between tumor cells and lymphocytes, might help to explain the discrepancy between gene amplification and protein overexpression results in gastric cancers., ERBB2 amplification is more frequent in micropapillary urothelial carcinoma than typical urothelial carcinoma, and patients with micropapillary carcinoma who have ERBB2 amplification have worse cancer-specific survival than those who do not., Next generation sequencing of micropapillary urothelial carcinoma revealed a high incidence of mutation in the extracellular domain of ERBB2., Immunohistochemical staining for EGFR, HER2 and IGF-1R was undertaken in 31 ovarian adult granulosa cell tumors. Tumor DNA was also analysed for mutations in the tyrosine kinase domain of EGFR (exons 18-21)., new role for PTPalpha in the regulation of motility of mammary epithelial cells in response to ErbB2 activation., 4 genes (EGFR, ERBB2, PTK2, and RAF1) with five SNPs (rs11238349, rs17172438, rs984654, rs11773818, and rs17172432) might be pivotal factors in the development of prostate cancer., HER2 and IGF-IR may be clinically beneficial in minimizing the acquired resistance to trastuzumab therapy., HER2-mediated phosphorylation destabilizes PUMA protein., Her2 status is associated with key clinical features and pathological characteristics of epithelial ovarian tumors but not with survival., data help to understand the HER2 overexpression in oxidative signaling and may enable the development of new strategies for anti-HER2 therapy, HER2 status in primary gastric cancer is a reliable basis for deciding whether to treat with anti-HER2 agents in patients with lymph node metastases., Studies indicate that changes in oestrogen receptor (ER), progesterone receptor (PgR) and epidermal growth factor receptor 2 (HER2) expression may occur during the natural history of breast cancer., In ER-positive cancers, high LI correlated with biologic parameters associated with poor prognosis, whereas in HER2 positive cancers, LI correlated with biologic parameters of good prognosis., Data suggest that trastuzumab may be effective in colorectal cancer, but only in tumors with the HER2 protein on their cell membrane, which accounts for approximately 5% of the patients., LKB1 expression in cancer cell resulted in dephosphorylation of several tumor-enhancing RTKs, including ErbB2, hepatocyte growth factor receptor (c-Met), EphA2, rearranged during transfection (RET), and insulin-like growth factor I receptor., Data show that S100A14 and HER2 are colocalized in plasma membrane of breast cancer tissue cells and breast cancer cell lines., miR-221 may promote trastuzumab resistance and metastasis of HER2-positive breast cancers by targeting PTEN, suggesting its role as a potential biomarker for progression and poor prognosis, we found that there were no associations between genetic variants in the 17q21 ERBB2 amplicon and GC susceptibility., We evaluated HER2 and cMet protein expression, and FGFR2 gene amplification to assess their prognostic significance in patients with gastric adenocarcinoma, Expression of ERBB2 is increased in nerve tissue from patients with neurofibromatosis type 2., High-level ERBB2 amplification is associated with shorter time-to-metastasis, but improved response to trastuzumab in metastatic breast cancer., Findings strongly suggest that mutations in the transmembrane domain of HER2 may be oncogenic, causing hereditary and sporadic lung adenocarcinomas., calretinin immunoexpression and the hormonal status for estrogen receptors (ER), progesterone receptors (PR), and ERRB2, in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors, were studied, Data indicate that responses were noted in patients with HER2-amplified breast cancer resistant to trastuzumab, HER2-mutant non-small-cell lung cancer, and tumor types without identified mutations in the HER-PI3K-mTOR pathway., Capecitabine/cisplatin doublet has an encouraging antitumor activity with acceptable and manageable toxicity in anthracycline- and taxane-pretreated HER-2 negative metastatic breast carcinoma patients., A prognostic biomarker for trastuzumab treatment in HER2-positive MBCs., Data demonstrate that the E2F transcription factors are integral to HER2+ tumor development and progression., ER and HER2 are useful markers in core needle biopsies, providing a reliable base for preoperative decisions in neoadjuvant chemotherapy, and may be omitted on surgical specimens with certain precautions and exceptions., High co-expression of HER-2, IL-6, TNF-alpha and TGF-beta1 is asosciated with breast cancer., ErbB2 overexpression controls HSF1 activity, with subsequent stabilization of tumor-promoting HSP90 target, MIF., High HER2 expression is associated with brain metastases arising from breast cancer with stereotactic radiosurgery., ALTTO ineligibility did not change when HER2 testing was performed ... a dual antibody ER assay had fewer false-negative test results than an assay with a single antibody., These results could justify more extensive research to assess p53 and HER-2/neu gene status as significant prognostic factors in oral cancers., Lapatinib plus vinorelbine offers an effective treatment option for patients with HER2-overexpressing MBC, having displayed comparable efficacy and tolerability rates to lapatinib plus capecitabine, In HER2-positive breast cancers, HR expression is associated with a poor prognosis despite the hormone therapy. For this population, a personalized management may be required., ERBB2 is overexpressed in fibrolamellar hepatocellular carcinoma., Anti-huHER2 antibodies elicited in the tolerant host exert antitumor activity., onstitutively active ERBB2 sensitizes human breast epithelial cells to agents that induce endoplasmic reticulum stress, EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms, Patients with stages I-III (including inflammatory) HER2-positive breast cancer were randomised to receive epirubicin., [review] HER2 over-expression is significantly correlated with phosphatidylinositol (PI)3 kinase-Akt expression in gastric cancer (GC) tissues and plays an important role in HER2-positive GC., Altogether, our study uncovered the existence of a novel Akt-HSF-1 signaling axis that leads to Slug upregulation and EMT, and potentially contributes to progression of HER2-positive breast cancer, The efficacy and safety of trastuzumab combined with SP in patients with human epidermal growth factor receptor type 2 (HER2)-positive AGC., Intratumoral heterogeneity of ERBB2 amplification, defined as less than 50% of cancer cells positive for ERBB2 amplification, was found in 41% (21/51) of ERBB2-amplified gastric adenocarcinoma tumors, Data suggest that epidermal growth factor receptor 2 discordance is mostly due to testing with only immunohistochemical (IHC) method., ERBB2-positive breast cancers are partially autophagy-deficient even in a wild-type BECN1 background, The folding pf Her2 is driven by chain A, which has a poor capacity to self-recognize and a strong tendency to form the internal bridge between Cys565 and Cys574., Eevaluation of HER2 status is certainly an important tool during the diagnosis of gastric cancer patients, Expression of beta-catenin, Ki67 and Her-2/Neu was studied in gastric cancer. The protein expression of beta-catenin, Ki67 and Her-2/Neu had close relationship with the clinical pathologic characteristics of gastric cancer., Positivity for HER2, MET and FGFR2 alternations was found in 23 (13.4%), 21 (12.2%) and 9 (5.2%) patients., Identify a molecular signature based on levels of pEGFR, pERBB2, and SMOX for the initiation of gastric carcinogenesis in helicobacter infected gastric epithelial cells., Suggest that HER2 positivity in upper urinary tract urothelial carcinoma is an independent predictive marker for early recurrence of urothelial carcinoma in the residual urinary bladder after surgery., The majority of SDCs express AR, HER2, and/or EGFR., A dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptor (EGFR)/HER2., Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R., Labeling anti-HER2 Nanobody 5F7GGC with *I-SGMIB yields a promising new conjugate for targeting HER2-expressing malignancies, High epidermal growth factor receptor-2 is associated with locoregional recurrence in patients with T1-T2 breast cancer., Although there was no difference in survival, C-erbB-2 overexpression was observed only in the glioblastoma subtype of Astrocytic tumors., HER2 Ile655Val polymorphism affects the function of HER2 gene only restricted in HER2-positive breast cancers, Overexpression of HER2 is associated with gastric adenocarcinoma., Our results demonstrate that both the wild-type and the mutant are 100% dimeric, suggesting that the Neu TM helix dimerizes more efficiently than other RTK TM domains in mammalian membranes, the study showed a significant association between low pleural glucose level and overexpression of HER2 in lung cancer., HER2 was positive in nearly 52 % of the primary tumors, and these expressed HER2 in corresponding lymph node and liver metastases in 93 and 100 % of the cases, respectively, our findings suggest miR-630 as a key regulator of cancer cell progression in HER2 over-expressing breast cancer, through targeting of IGF1R., ). Our study demonstrates strong concordance between biopsy and resection specimens for HER2 overexpression in gastric cancer. Discordance was correlated with tumor heterogeneity, Multiple HER2 gene copies lead to different protein expression patterns (score 1+ to 3+) but pure gene amplification is only a subset of them, there was no correlation between the p95-HER2 expression and resistance to trastuzumab., An EGFR/HER2-Bispecific and enediyne-energized fusion protein shows high efficacy against esophageal cancer., CONCLUSION, HER2 overexpressing tumours in older women showed relatively a less aggressive phenotype and did not show any inferior long-term clinical outcome despite not having received chemotherapy when compared with the younger patients., Data show that high P95HER2 (p95, a truncated form of the HER2) expression correlated with shorter progression-free survival and overall survival in the hormone receptor-positive subgroup of patients, but not in the hormone receptor-negative group., The evidence of HER2 positive metastatic lesion and primary colorectal cancer suggest that HER2 assessment might be considered in selected cases when this may help change the therapeutic decision., none of the associations were replicated whether analysed for leprosy per se, LL leprosy, TT leprosy, erythema nodosum leprosum or reversal reaction conditions., Affinity-purified bispecific Affibody molecules, targeting HER2 and HER3., Estradiol does not repress HER2 gene transcription but the repressive response can be restored by overexpression of ANCO1., No TOP2A amplification occurred without HER2 co-amplification in an analysis of breast cancer in tissue microarrays from a clinical cohort study., In conclusion HER2 and GATA4 are new molecular prognostic markers of GCT recurrence, which could be utilized to optimize the management and follow-up of patients with early-stage GCTs, we propose that the HER2 gene copy number value should be included as an additional indicator for stratifying both the management and the follow-up of breast cancer patients., the ErbB3/4 ligand heregulin (HRG) reduced both ErbB2 and ErbB3 mRNA and protein levels in human breast cancer cell lines., Data indicate that signal transducer and activator of transcription 1 (STAT1) activation leads to HER2/ERBB2 downregulation in cancer cells., HER2 amplification is found in a subset of uterine papillary serous carcinomas. Screening with immunohistochemistry will overestimate the number of cases showing underlying HER2 gene amplification., We show for the first time the presence of HER2/HER3 heterodimers and the loss of p21 expression in HER2+ breast cancer predicts a significantly poorer outcome when submitted to adjuvant trastuzumab, The role of targeted agents for metastatic HER2-positive breast cancer is under active clinical trial investigation and we await the maturation of trial results and long-term survival data, Results suggest that FoxM1 and Her-2 are important diagnostic markers for gastric cancer., These findings deciphered the molecular mechanism of HBx-mediated HER2 upregulation in HBV-associated HCC., The expression of her-2 is closely related to differentiation degree, infiltration depth, lymph nodes' metastasis and pTNM stage of the esophageal cancer and to prognosis., Positive HER-2 status was significantly associated with poor 5-year disease-free survival and 5-year overall survival in patients with locally advanced rectal cancer., conclude that ARTN is one mediator of acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells, Delayed fixation impaired HER2 protein expression assessed using immunohistochemistry in 22% of 3+ carcinomas. HER2 amplification assessed using FISH may be less affected., HER2 overexpression drive the aggressive behavior of the estrogen receptor-positive breast tumors without downregulation of luminal proteins., Depletion of either flotillin-1 or flotillin-2 resulted in downregulation of ErbB3 and a selective reduction of ErbB2-ErbB3 receptor complexes., CD24 supports the expression of HER2 and the consequent activation of PI3K-Akt signaling in HER2-positive breast cancer cells., HER2 overexpression is not an independent prognostic marker of colorectal cancer, but DcR3 overexpression is highly correlated with lymph node metastasis and poor overall survival, HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer., Results suggest that serum HER2 could be a useful real-time marker for tumor burden and recurrence in patients with HER2-positive disease., Multiple roles of perforin in hampering ERBB-2 (Her-2/neu) carcinogenesis in transgenic male mice., These data reveal the distinct roles of EGFR and HER2 on expression of matrix macromolecules in cancer cells., The ERBB2 mutation was revealed to be one of the most frequent alterations in small bowel adenocarcinoma with a distribution dependent on tumour location., new class of protein cancer biomarker candidates, Results show that c-erbB2-induced epithelial-mesenchymal transition is not affected by ectopic expression of E-cadherin., Suggest prolidase as a high affinity ligand of the ErbB2 receptor which can regulate ErbB2 signaling and cell growth., interaction of a kinase of the Src family with ErbB2 C-terminal domain, The HER2 oncogene is a bi-functional locus., These findings suggest cooperative roles for bile acid and erbB2 activation in epithelial cell proliferation; bile acid appears to accelerate erbB2-induced pro-tumorigenic activities in the biliary tract and skin., HPV 16 infection induce upregulation of HER2/neu, pStat3 and IFI16., Study addresses whether the ERBB3 mutations altering Val-104 were present in homologous amino acids of ERBB family genes EGFR, ERBB2 and ERBB4 in CRC., No significant differences according to the HER2 inhibition were found., HER2 gene amplification was identified in a minority of CRC patients., These results suggest that H. pylori CagA may induce overexpression of the HER-2 protein by increasing HER-2 DNA and mRNA copy number, High levels of HER2 are associated with achievement of a pathologic complete response in the preoperative setting, while levels of phospho-HER2 were not predictive of response in breast cancer patients., Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent resistance to lapatinib in breast cancer., these results suggest that there may be a subgroup of patients with an exceptional response to trastuzumab emtansine based on high HER2 mRNA expression levels., Studies suggest that C-erbB2 (HER-2/neu)overexpression is related to poor prognostic of osteosarcoma and can be a useful clinical prognostic factor for those patients., Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival., Identifying FGFR2 as a transcriptional regulator of rDNA in bone unexpectedly reveals a nucleolar route for FGF signaling that allows for independent regulation of osteoprogenitor cell proliferation and differentiation., These data support the concept that activation of ERBB family members is sufficient to bypass dependency on FGFR3 and suggest that concurrent inhibition of these two pathways may be desirable when targeting FGFR3-dependent cancers., These results suggest an important role of HER2 in the activation of G2/M checkpoint response following IR., Together, our results indicate that c-FLIP(L) promotes TRAIL resistance and inhibits caspase-3 and caspase-8 activation in HER2-positive breast cancer., HER2/neu protein is credibly overexpressed in colon and gastric adenocarcinomas in immunohistochemistry, HER-2 was expressed in a proportion of osteosarcoma patients, and can serve as a target for antineoplastic therapy. (Review), Results show that Cholangiocarcinoma express differentially HER2 protein based on tumor location., ERBB2 collaborates with androgen signaling to promote prostate cancer metastasis., These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells., HER2 amplification characterizes one intrinsic subtype of gastric cancer associated with a specific phenotype, as it is most commonly found in proximal gastric cancers. [Review], Higher ADAM10 levels correlated with poorer relapse-free survival (p = 0.01) in a cohort of HER2 positive breast cancer patients treated with trastuzmab., Increased ErbB2 mRNA expression in peripheral blood leukocytes from breast cancer patients., HER2 overexpression is more common in male patients with high grade urothelial carcinoma of the renal pelvis., studies suggest that p95HER2 constitutes a new surrogate marker for an aggressive HER2-positive breast cancer subtype with distinct clinical and biological features, Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer, results demonstrate that HER2-amplified ductal carcinoma in situ constitute a clearly distinct subgroup which is characterized by histopathological features associated with poor prognosis, High circulating epidermal growth factor receptor 2 is associated with hyperglycaemia and insulin resistance, Study identified novel microRNAs that were differentially expressed according to the HER2 status across different tumor types., DFF has no statistically significant effect on the HER2/CEP17 ratio tested by Dual-ISH. However, significant artifacts could occur in samples fixed after 1 hour of DFF time., Her2 expression in in locally advanced gastric cancer with extensive lymph node metastasis, Provide additional prognostic information when evaluating clinical features of ER(+), HER2(-) early breast cancer., HER2 positivity was seen in 17.6% of all cases of breast cancer from a single center in Kenya., Besides tumour stage, grading and nodal status, the Her2-neu score 0 is able to function as a prognostic factor in patients with TNBC., In tDNA, 50 mutations (36 EGFR, 5 ERBB2, 4 KRAS, 3 BRAF, and 2 PIK3CA) were identified, of which 26 were detected in cfDNA. These data demonstrate the feasibility and potential utility of mutation screening in the detection of a range of tumor biomarkers, Relationship between hormone receptors and Her-2/neu in proportionally inverse; when high hormone receptors negativity is present there is also a Her-2/neu highly overexpressed, HER2/HER3 co-overexpression is significantly associated with impaired survival from diagnosis of metastatic disease in patients with HER2-positive metastatic breast cancer., HER-2/neu but not PTEN expression is an independent prognostic factor for type I endometrial carcinoma, HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma., Data suggest that expression of EGF, EGF receptor, and c-erb-B2/ERBB2 in gastric mucosa is up-regulated during (1) gastritis with Helicobacter pylori infection, (2) gastric cancer, and (3) gastric cancer with Helicobacter pylori infection., Report protective role of ErbB2 modulation in human-induced pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin., Transcriptional analysis revealed 15 genes to be differentially expressed between the two groups highlighting that Her2 signaling in primary tumors could be associated with specific blood gene expression, HER-2 overexpression is associated with colorectal cancer., PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes., The meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC., High HER2 expression is associated with breast cancer., A mutually exclusive pattern of FGFR2, HER2, and KRAS gene amplification and survival trends in gastric cancer patients., TOP2A FISH and qPCR may not identify the same pathology on chr17q. Non-HER2 chr17 CN patterns may further predict outcome in breast cancer patients with known favorable and unfavorable prognosis., The expressions of HER-2/neu (c-erbB2), survivin and cycline D1 are positively correlated with the malignant potential of serous ovarian neoplasms., Overexpression and gene amplification of HER2 was found in biliary tract carcinomas., HER2 overexpression in ovarian primary mucinous adenocarcinomas is associated with an expansile, but not an infiltrative, invasion pattern and a favorable prognosis, serum HER2 ECD are highly correlated with tissue HER2 status in metastatic gastric cancer, High HER2 expression is associated with gastric cancer., Results show that poly (ADP-ribose) polymerase (PARP) inhibition has antitumour effects and increases trastuzumab activity in oncogene protein HER2 overexpressing breast cancer., Complete HER2 concordance existed between IHC and FISH tests for the Her2 gene copies per tumor cell in mucinous epithelial ovarian cancers., This work reveals that DeltaNErbB2 strongly affects several major pro- and antiapoptotic pathways and provides mechanistic insight into the role of NHE1 in chemotherapy resistance, Differentiation from primary sarcoma is of paramount importance. Skeletal muscle metastases usually indicate an advanced disease associated with poor prognosis. Treatment should be individualized depending on the patient's clinical condition., our results establish the d16HER2 signaling axis as a signature for decreased risk of relapse after trastuzumab treatment., In this study, PR negativity was a prognostic factor for early relapse in luminal B/HER2-negative breast cancer, while a high Ki-67 index suggested a higher risk of early relapse., in responding cells (LNCap and DU-145) HER2 expression decreased, accompanied by increased EGFR expression, Four weeks of neoadjuvant lapatinib in patients with HER2-positive DCIS resulted in inhibition of HER2 and RAS/MAPK signaling pathway, HER2 promotes tumor cell survival by inhibiting apoptosis i.e. by downregulating CASP-3 and CASP-8., Her2 and estrogen receptor status influence the prognostic significance of FOXP3 positive tumor infiltrating lymphocytes in breast cancer., Expression levels of ER, PR, and HER2 were analyzed to determine clinical significance of four molecular subtypes of endometrial cancer., Elevated expression of the ER-alpha36-EGFR/HER2 loops is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen therapy., HER2 positivity significantly correlated with higher stages and lymph node metastasis in colorectal carcinoma., There was no association between ErbB2-IR and the androgen receptor (AR)-IR in the tumours, but an interaction between the two parameters was seen with respect to their association with the tumour stage., Our findings show an evident change in ER, PR and HER2 between breast primary tumors and relapsing tumors. The unstable status for ER or HER2 in breast cancer seems to be clinically significant and to correlate with a worse prognosis., EndoPredict high-risk ER+/HER2- breast cancers are more likely to respond to anthracycline-based chemotherapy., Our study demonstrated that HER2 overexpression is an independent prognostic factor in patients with any stage of resectable gastric cancer, Activation of PKC-alpha and -delta mediates a novel positive feedback loop by promoting ErbB2 entry into the endocytic recycling compartment., Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression, The HER2Bi-armed activated T cells with anti-tumor effects may provide a promising immunotherapy for colorectal carcinoma in the future., NTS/NTSR1 complex enhances breast tumor aggressiveness via EGFR/HER2/HER3 pathway., Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib., Chemotherapy sensitizes p95HER2/611CTF-positive patient-derived xenograft tumors to trastuzumab. This sensitization may be related to HER2 stabilization induced by chemotherapy in p95HER2/611CTF-positive cells., This study has revealed a strong association between the expression of WLS and HER2 that has important biological and clinical implications., Patients with HER2neu-positive ductal carcinoma In Situ had greater extent of disease by imaging and were more likely to undergo mastectomy than HER2neu-negative., Erbin is an ErbB2 regulator for breast tumor formation and progression, HER-2/neu overexpression is associated with gastric carcinoma., there is HER2 and EGFR, but not VEGFR expression in micropapillary urothelial carcinoma with invasive urothelial carcinoma, Both HER2 and TACC1 expression were independent prognostic factors in patients with gastric carcinoma., Tumour SUVmax could be an imaging biomarker for predicting ALNM Tumour SUVmax predicting ALNM is effective in ER-positive/HER2-negative and HER2-positive subtypes, HER2 interacts with beta-catenin, leading to dissolution of the adherens junction, decreased cell-cell adhesion, and disruption of the pulmonary epithelial barrier., Mutations in exon 15 and 20 were more potent than wild-type HER2 in associating with activating signal transducers and inducing survival, invasiveness, and tumorigenicity., Discordance between the results of immunohistochemistry/fluorescence in situ hybridization detection of HER2 in both ductal and lobular carcinomas is largely associated with chromosome 17 aneuploidy., This study contributes to elucidating the intrinsic relations among breast cancer subgroups defined by ER, PR and HER2 expression via integrating mRNA and miRNA expression, HER2 overexpression is associated with ovarian mucinous carcinomas., The content of HER-2 protein and amplification of HER2 and CEP17 correlated with the clinical morphological parameters of patients with nonsmall cell lung cancer., Epidermal growth factor receptor overexpression, but not high EGFR copy number, is a poor prognostic factor in HER2-positive primary breast cancer., The HER-2 form of breast cancer is more aggressive and associated with worse survival outcomes compared with patients without HER-2 overexpression., These results indicate that pathologic activation of Src is a potential mechanism of acquired resistance to ERBB2 inhibition in ERBB2-amplified gastroesophageal cancer., Immunohistochemical profile of breast cancer with respect to estrogen receptor and HER2 status., Elevated circulating Her-2/neu extracellular domain is associated with aggressive breast cancer., This model demonstrates the role of ErbB receptors underlying prolactinoma tumorigenesis and the feasibility of targeting these receptors for translation to treatment of refractory prolactinomas., Combined inhibition of MKP1 and HER2 enhanced cell killing in breast cancer. Together, our findings identify a new mechanism of resistance in breast tumors and reveal MKP1 as a novel therapeutic target for radiosensitization., Circulating tumor cells expression of ER, BCL-2, HER2, and Ki67 can be reproducibly measured with high analytical validity using the CellSearch System., suggest that accurate assessment of HER2 status, including HER2 heterogeneity, it is essential to confirm any EGFR L858R-positive cases by molecular methods or at least discard the presence of HER2 overexpression/amplification before rendering a diagnosis, Reduced tumor invasivenes was the most significant biologic effect in breast cancer cells when HER2 and IGF-1R were cotargeted., HER2 expression in fine needle aspirates of lymph nodes detected by preoperative axillary ultrasound in breast cancer patients., Data show that a phenotypical implication of 655Val could be related to a cardiotoxicity risk upon Trastuzumab treatment., Her2/Her3 and Met/Her3 were verified in human GC., Study indicates that quantification of HER2 mRNA expression with the RT-qPCR could be an alternative method of conventional IHC/FISH methods., EGFR is commonly coamplified with ERBB2, and in the setting of ERBB2 amplification, higher EGFR expression appears to mark tumors with greater sensitivity to dual EGFR/ERBB2 kinase inhibitors., The study determined the prognostic significance of Her2 status in gastric cancer and identified clinicopathological factors predictive of Her2 positivity., LMP2A may suppress the HER2 expression through the TWIST/YB-1 axis in Epstein-Barr virus-associated gastric carcinoma, The single nucleotide polymorphism +936 C/T VEGF is associated with human epidermal growth factor receptor 2 expression in Moroccan breast cancer women., Phosphorylated ErbB1-4 and heregulin contribute to poorer patient prognosis in CRC. This heregulin-ErbB family member autocrine loop may be a candidate for targeted treatment of CRC., Increased HER2 expression is associated with cancers of pancreas and biliary tract neoplasms., Doxorubicin and methotrexate combination therapy down regulates HER2 gene expression and improve clinical outcome is OSCCs., Data suggest a role for stem cells proliferation in cell surface receptor HER2-regulated breast cancer tissue., These results for the first time indicated that a cross talk in FASN and HER2 expressions might be associated with prognosis in malignant ovarian cancer., Data indicate that HER2-negative tumors with HER2-ICD positivity exhibit clinical behavior closer to that of HER2-positive tumors., HER2 over-expression rate is relatively low among stage I-III gastric cancer patients, and might be generally not associated with clinicopathological characteristics., Serum Her2 level combined with CA-15-3 were strong and independent indicators for a worse disease free survival in patients with early breast cancer., Patients with HER2-amplified tumors were more likely to present PIK3CA mutations compared to patients with triple negative tumors., our findings indicate that total levels of HER2 can predict benefit for the combination of L+T. The added value of HER2 quantification is indeed its predictive power., Active HER2 binds and regulates the NRF2-dependent transcriptional activation., HER2 mutations were observed in 3.6% of NSCLCs, Amongst the patients with HER2 mutations, HER2 amplification and phosphorylation were independent prognostic factors., HER2 gene amplifications, and wild type KRAS genes are common in eyelid sebaceous carcinomas, analysis of activator-receiver preferences among ErbB proteins, Data show that the combination of PI3 kinase inhibitors with ErbB receptors HER2/HER3 targeting antibodies may constitute a promising therapeutic strategy for prostate cancer., Study shows that although HER2 expression itself was not a prognostic factor, the combination of HER2 expression and loss of heterozygosity of PTEN exacerbates the malignant potential of gastric cancer through its proliferative function., the concordance rate in HER2 status between primary gastric carcinoma (GC) and synchronous lymphnode metastases, was investigated., Standard slide-based tests for overexpression or amplification of ERBB2 would fail to detect the majority of activating mutations that occur overwhelmingly in the absence of copy number changes, study found that serum HER2 extracellular domain (ECD) level was correlated with a poor prognosis in primary breast cancer, and that patients with an elevated HER2 ECD level had worse survival rate than those with normal HER2 ECD levels., one can suppose that the structural features of DNA are involved in the formation of ERBB2-containing amplicon borders in breast cancer cells and the data are of importance for understanding the mechanisms of oncogene amplification., Case Report, This study suggests that TFF3 is an independent indicator for survival in GC, while HER2 is not associated with the outcome. Patients with HER2-negative/TFF3-negative GC have the best outcome., we investigate whether inhibiting HUNK impairs in vivo tumor growth that is initiated by HER2 inhibitor-resistant breast cancer cells., Trastuzumab(monoclonal antibody targeting HER2)significantly improves the survival of women with HER2 breast cancer.IHC and FISH testing of HER2 must be accurate results to predicting patients' responses to HER2-targeted therapy., This meta-analysis suggests that HER-2-positive status is not an independent adverse prognostic factor for survival among Inflammatory breast cancer patient cases., The meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model., The addition of CDK4/6 inhibitor palbociclib to letrozole in this phase 2 study significantly improved progression-free survival in women with advanced oestrogen receptor-positive and HER2-negative breast cancer., miR-7 regulated pathways, including EGFR and Src kinase, represent targets for the therapeutic intervention of refractory and metastatic HER2Delta16 driven breast cancer, Activating the PI3K pathway is associated with low pathological complete response to trastuzumab-based treatment in HER2-positive breast cancer, HER2 signalling mechanisms along with the repertoire of HER family and other targeted therapies, it is likely that the near future holds further dramatic improvements to the prognosis of women with HER2-positive breast cancer., HER2 positivity occurs in 15.6 % of invasive gastroesophageal adenocarcinoma in Western patients, of which the majority is esophageal primary tumors and of the intestinal tumor type., An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression in larynx carcinoma., Report rapid fluorescence in situ hybridisation for HER2 assessment in breast and gastro-oesophageal cancers., roles of ESR1-mediated transactivation and transrepression in the regulation of invasiveness of ESR1+/HER2+ breast cancer cells by E2, p27 accumulated in the cytoplasm of breast cancer cells exclusively in cell lines that are Her2+., ErbB2 and ErbB3 homodimers are endocytosis deficient owing to the lack of endocytic codes. Interestingly, EGFR-ErbB2 or EGFR-ErbB3 heterodimers are also endocytosis deficient, The synergism between HER2 and EGFR in determining radiosensitivity., loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway., Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2)., PRP4K functions as a HER2-regulated modifier of taxane sensitivity that may have prognostic value as a marker of better overall survival in taxane-treated ovarian cancer patients., High grade endometrial cancer expresses higher levels of p95HER2., Suggest that TXNIP plays a critical role in anti-Her-1/Her-2 treatment and may be a potential prognostic marker in breast cancer., Gastric and esophageal neoplasms are characterized by wide HER2 genetic heterogeneity., The tripartite antibody mixture induced efficient HER2 internalization., Gastric cancer cells that express the HER-2 oncogene spur the activation of NF-kappaB that can upregulate the expression of ICAM-1 and induce the expression of MMP-9, which hydrolyzes ICAM-1 into s-ICAM-1 to promote tumor immune escape., Ad-HER2-ECD can efficiently transduce HER2-ECD into HER2-negative human cancer cells. PIT with trastuzumab-IR700 induced direct cell membrane destruction of Ad-HER2-ECD-transduced HER2-negative cancer cells, Our study suggests addition of imetelstat to trastuzumab may enhance the effects of HER2 inhibition therapy, especially in the CSC population., Both HER2 and MMP-9 may be required to effectively block HER2 signaling in gastric cancer therapy., results show that there is no association between the genotyped SNPs and the disease (p>0.05) in this population., there is a correlation between plasma membrane associated beta-catenin in HER2-positive breast cancer and survival outcome, In urothelial carcinoma overexpression of HER2 protein and gene was evident in all stages, regardless of schistosomiasis status., determination of HER2 copy number variations by SNP array-based genomic segmentation analysis is an effective supplement to IHC/FISH HER2 analysis., Symptom burden and quality of life among women with HER2(+) metastatic breast cancer., HER2-trogocytosis is visible evidence of tumor microenvironment interaction between cancer cells and immune cells., Dacomitinib growth inhibition was associated with a significant and dose-dependent decline in phosphorylated HER2/neu and S6 transcription factor and a dose-dependent and time-dependent cell cycle arrest, The selective anticancer activity of hirsutine in HER2-positive breast cancer by inducing a DNA damage response., Our findings suggested that there was positive feedback regulation between FASN and HER2 expression and phosphorylation in osteosarcoma cells., suggest that ECM-detached ErbB2-expressing cells may be uniquely susceptible to targeted therapy against EGFR and that this sensitivity could be exploited for specific elimination of ECM-detached cancer cells, Findings indicate a pathway involving protein-tyrosine phosphatase D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 receptor function., The expression of Bcl-2 was an independent, favorable prognostic factor in breast cancer patients with the HR+/HER2- subtype., c-MYC expression is up-regulated through the cross-talk between ER and HER2 in aromatase inhibitor resistant breast cancer cells., Loss of HER2 amplification is associated with melanoma., Lapatinib failed to show efficacy as either monotherapy or in combination with capecitabine in the treatment of HER2 amplified gastro-esophageal cancers., Expression of HER2 and pAKT define a population of patients with stage IV pulmonary adenocarcinoma with a distinct disease course., Studies suggest that observations may have significant therapeutic implications in cancers not traditionally thought to benefit from anti-HER-2 proto-oncogene protein) therapies., HER2 IHC status, HER2/CEP17 ratio, and HER2 GCN were correlated with clinical outcomes of trastuzumab-based treatment in HER2-positive advanced gastric cancer, High Tau-protein and low PTEN expression showed a significant association with poor response to H + P chemotherapy in patients with HER2-positive advanced breast cancer., Report high expression of HER2 in gastric adenocarcinomas., HER2 positivity was increased in BRCA2 breast cancers compared to non-BRCA familial and BRCA1 breast cancers., HER3 overexpression strongly correlated with HER2 positivity in this cohort of patients, CK5/6 have roles in biologically aggressive tumors likely to display resistance to trastuzumab ab initio in women diagnosed with HER2+ cancer, Genetic induction of fibronectin by HER2 triggers cell adhesion and invasion capacities., HER2/CD3 BsAb efficiently inhibited the growth of breast cancer tissue by activating and inducing the proliferation of tumor tissue infiltrating lymphocytes., Study shows an inverse association between the level of HER2 amplification and survival time in a relatively large cohort of HER2-positive breast cancer patients where greater HER2 amplification level is correlated with worse outcome., Results show that Her2 gene is particularly amplified in 38% of breast tumors of patients exposed to ionizing radiation during there childhood., In this study, we demonstrate that 5a-induced cell cycle arrest and apoptosis by inhibiting EGFR and HER2 activity and downstream activation of PI3K/Akt and MEK/Erk pathways., A substantially higher frequency of HER2 mutations occur in pleomorphic invasive lobular carcinoma, compared with that in classic invasive lobular carcinoma., Progesterone receptor status exerts a significant impact on prognosis of estrogen receptor+/HER2- breast cancer., Neoadjuvant chemotherapy reduces HER2 expression in breast cancer patients., Human epidermal growth factor receptor 2 (HER2)-activating mutations are present in 1% to 2% of lung adenocarcinomas, with predominance in never smokers, association with gene amplification and overexpression, HER2 status was highly concordant between the paired primary and brain tumors, whereas changes of ER and PR status occurred in a substantial proportion of the patients, overexpression of HER2 exhibited stronger negative effect on the prognosis of ILC patients than that in IDC patients, suggesting that treatment targeting HER2 is crucial for this BC subgroup, HER2 amplified bladder cancer feature specific morphological characteristics., in breast carcinoma, HER2 status in the presence of polysomy 17 may vary with the scoring criteria used, HER2 and EGFR)on the breast cancer xenografts in a mouse orthotopic model were successfully detected in a multiplexed way, illustrating the potential of FRES as a molecular diagnostic instrument, EGFR, ErbB2 and MET genes are frequently amplified in gastric carcinoma., Report shows that HER2 positive breast cancers exhibit increased expression of PARP1 and phospho-p65., Data show that proto-oncogene protein HER-2 is directly regulated by microRNAs miR-125a and miR-125b in small cell lung cancer (SCLC)., the tumor HER2 status determined in the biopsy specimen significantly reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs, HER2 expression in gastric/GEJ adenocarcinomas shows some differences compared to what is observed in breast adenocarcinomas, most notably basolateral or lateral membranous positivity and increased heterogeneity. [review], negative-ER ,negative-PR ,positive-p53 and higher Ki-67 expressions were related to a higher mtDNA copy ratio. In addition, advanced T-status (p=0.019) and negative-HER-2/neu expression (p=0.061) were associated with mtDNA D310 mutations, Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients., Considering simultaneously tumor pathophenotypes and several molecular levels, we show the heterogeneous behavior of ERBB2-positive breast cancer in terms of disease progression, The tumorigenic function of the HER2 H878Y mutation., HER2 expression may have potential as a prognostic factor for intestinal cancer types, using dual paraffin blocks to assess Her2/neu expression of gastric cancer may help identify more patients with Her2/neu-positive gastric cancer, We did not find that c-erbB-2 expression was associated with the prognosis of gastric cancer. [Meta-analysis], explore the effects of the HER2 gene and Herceptin on circulating tumor cells., Her2/neu single nucleotide polymorphisms may be useful in conjunction with other biomarkers to risk stratify patients in order to optimize clinical management., Quantitative HER2 measurement by HERmark is highly sensitive, accurately quantifies HER2 protein expression and correlates well with routine HER2 testing., Essential activating sequence exists in the extracellular domain of HER2. Disruption of this sequence disables HER2 dimerization loop, blocks subsequent activation of HER2-driven oncogenic signaling, and generates a dominant-negative form of HER2., results provide the molecular basis of a novel resistance mechanism to trastuzumab-based anti-HER2 therapy, supporting additional molecule stratification within HER2-positive GC patients for more effective therapy options, Data (including data from SZ95 sebocyte cell line) suggest sebocytes abundantly express EGFR (epidermal growth factor receptor) with lower levels of ERBB2 and ERBB3; expression of these receptors appears coordinated with lipogenesis in specific ways., ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2., HER2 mutation is associated with lung cancers., Regardless of methodology, basal-like cases seldom expressed ER/ESR1 or PR/PGR and were associated with the lowest expression level of HER2/ERBB2 relative to other subtypes., HER2 overexpression was seen in one-third of primary gastric cancers with lymph node metastases. As the receptor expression may lose/gain in the metastases assessment of the receptor status in metastatic lesions is encouraged., HER2 detection in mixed gastric carcinoma displays high heterogeneity., Data show that proto-oncogene protein HER-2 overexpression occurs in only 8% of patients with colorectal cancer (CRLM) but with 75% of cases proto-oncogene protein HER-3 is frequently overexpressed in CRLM., Our data suggest that physical activity reduces risk of invasive breast cancers that lack HER2 overexpression, increasing our understanding of the biological mechanisms by which physical activity acts., HER2 2+ status is an unfavorable prognostic factor regarding the OS of breast cancer patients with intermediate grade of differentiation and could be used to identify patients, who may benefit from adjuvant therapy., Exogenously expressed HER2 failed to associate with EGFR or HER3 in MDA-MB-231 cells, while overexpression of HER2 enhanced HER family dimerization in MCF-10A and MCF-7 cells, Metformin increases survival in hormone receptor-positive, HER2-positive breast cancer patients with diabetes, Positive stromal PAI-1 protein expression may identify a subgroup of HER2-negative advanced breast cancer patients., mir-4728, an intron of the ErbB2 gene, is a negative regulator of MAPK signaling through directly targeting the ERK upstream kinase MST4 and exerts numerous tumor-suppressive properties, SATB1 and HER2 expression correlated with poorly differentiated breast cancer and indicated an unfavorable prognosis., Gene amplification and immunohistochemical overexpression of ERBB2 occurred in 13% of all ampullary carcinomas, therefore providing a potential target for anti-HER2 therapy in these tumors., Measurements of HER2 experession in intracellular domain (ICD) and extracellular domain (ECD) in breast cancer suggest a subclassification of HER2-positive tumors, This review summarizes the molecular characteristics, etiology, preclinical tools and therapeutic options for hormone receptors+ (i.e., estrogen receptor and progesterone receptor) HER2+ breast cancer. [review], Downregulation of the expression of HER2 by small interfering RNA in human meningioma cells significantly inhibited cell motility and proliferation, led to cell cycle arrest at the G0/G1phase and increased early apoptosis., HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive., HER2 inhibition can enhance or restore ER expression with parallel Bcl2 upregulation, representing an ER-dependent survival mechanism potentially leading to anti-HER2 resistance., The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer., Report allelic imbalance at the HER2/TOP2A locus in breast cancer., In non-small cell lung cancer there is an elevated HER2 protein level and, well less frequently, altered activity in the HER2 gene., COX-2 and HER-2 are important markers for invasion and metastasis of colorectal cancer, and they act together to regulate the invasion and metastasis of colorectal cancer., These results support the role of the HER2 655 A>G polymorphism as a genetic marker of trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients., We also established the rarity of HER2 mutation in TNBC., Improved prognostic tools for DCIS patients are warranted to tailor adjuvant therapy. Here, we demonstrate that HER2 positive disease in the primary DCIS is associated with lower risk of recurrent invasive breast cancer., ERBB2 gene amplification is detected in approximately 40% of isolated HLA-G(+) trophoblasts., loss of HER2 protein expression due to loss of DMs containing HER2 is not a likely mechanism of resistance to anti-HER2 therapies., AR is not associated with the proliferation marker Ki-67, but is associated with lower 21-gene recurrence score in estrogen receptor positive/HER2 negative breast cancer., GPNMB might be a surrogate marker for BC and may cross talk with the HER2 signal pathway., Study shows the phosphorylation of EGFR and HER2 after MEK inhibition in a MEK1-mutated gastric cancer cell line suggesting that EGFR and HER2 activation may serve as a potential mechanism responsible for the resistance to a MEK inhibitor., High co-expression of Sp1 and HER-2 is correlated with gastric cancer., The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree., Results show that ESR1 and ERBB2 were found to modulate the most numbers of gene pairs in breast neoplasm and they share complex interplay between each other suggesting a role in breast cancer pathogenesis through gene regulation., Given the high prevalence of lung cancer and the availability of targeted therapy, Chinese lung ADC patients without EGFR and KRAS mutations are recommended for HER2 and BRAF mutations detection, especially for those never smokers, FASN and HER2 have roles in breast cancer and are blocked by EGCG with pertuzumab or temsirolimus, Our results indicate that the transactivation of HER2 and EGFR by the pro-inflammatory cytokine/neuropeptide SP in BC cells is a c-Src and MMP-dependent process., C-erbB-2 was expressed in gastric carcinoma, gastric mucosal atypical hyperplasia and gastritis. Expression correlated positively with degree of cell differentiation. C-erbB-2 played an important role in the pathogenic mechanism of gastric carcinoma., VEGFC and VEGFR1 mRNA overexpression is of prognostic value, dependent on HER2 status., In vitro affinities of the panel of evolved DARPins directly correlated with the fluorescence intensities of evolved DARPins bound to HER2 on a breast cancer cell line, Expression of total HER2, total HER3 were significantly elevated in HPV(+) HNSCC., Increased gene copy number of HER2 and concordant protein overexpression was found in a subset of eyelid sebaceous gland carcinoma., Data suggest that AMP-activated protein kinase (AMPK) regulates HER-2 proto-oncogene protein and epidermal growth factor receptor (EGFR) in HER2-amplified breast cancer cells and activation of AMPK might provide therapeutic benefit in such cancers., MLK3 represents a newly recognized integral component of HER2 biology in HER2+ breast tumors., 8.7% of this Pakistani breast cancer cohort were HER2 overexpressing., ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium., Promote the internalization of T-DM1 into HER-2 positive cancer cells., Helicobacter pylori-positive gastric cancer showed more Her2/neu overexpression., HOXB7 Is an ERalpha Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance, In this study, we report that miR-205-5p is highly expressed in BCSCs and represses directly ERBB2 and indirectly EGFR leading to resistance to targeted therapy., The presence of tumor infiltrating lymphocytes at diagnosis is an independent, positive, prognostic marker in HER2-positive early breast cancer treated with neoadjuvant anti-HER2 agents., High HER2 expression is associated with breast cancer., HER2 and PTEN expression appears as early as the 9-12 weeks period in the digestive tract, but HER2 expression decreases in the 21-24 weeks period and then disappears. EGFR appears only during the 13-16 weeks period and p53 is strong until week 21., these studies support the rationale to target the NRG1-ErbB3-ErbB2 axis as a novel treatment strategy in a subset of cutaneous melanomas., SNP in HER2 codon 655 and investigation of HER2 and HER3 expression could be helpful to outline the prognosis for patients with lung adenocarcinoma., HER2-positive early breast cancer patients receiving adjuvant trastuzumab with high pretreatment neutrophil/lymphocyte ratio had shorter disease-free survival., Suggest that clinical course of KI67/Her2 positive breast cancer was determined by hormone receptor status rather than Ki67 expression., The combined impacts of alphav-integrin and HER2 influence the invasive phenotype of breast cancer cells., Our results suggest that it may be valuable to add agents targeting the STAT3 pathway to trastuzumab for treatment of HER2-positive breast cancer., It is suggested that tumor substaging and HER2 status are independent predictive markers for tumor progression or recurrence, and thus could be included in diagnostic and therapeutic management for NMIBC., ARPE-19 cells have low ErbB2 expression, and overexpression and knockdown experiments revealed that robust ErbB2 expression bypassed the requirement for clathrin for EGF-stimulated Akt phosphorylation., Suggest that androgen receptor and PTEN status might be considered as indicators of trastuzumab sensitivity in HER2-positive breast cancer patients., results suggest ErbB-2 is a prominent player in mediating the ligand-dependent and -independent activation of androgen receptor in androgen-sensitive and androgen-independent/castration-resistant PCa cells respectively for PCa progression and survival., Our results establish HER2Ab-NSCs as a novel, nontoxic, and rational therapeutic approach for the successful treatment of HER2 overexpressing BCBM, which now warrants further preclinical and clinical investigation., Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt pathway and promoting erbB2-driven mammary/breast tumorigenesis., The finding from this present meta-analysis suggested that HER-2 overexpression was not related to clinicopathological characteristics and poor prognostic of colorectal cancer patients., p95HER2-positive CTCs can be detected in both early and metastatic breast cancer patients., findings support the use of in situ single cell-based methods in cancer genomics and imply that chemotherapy before HER2-targeted therapy may promote treatment resistance, The proportion of a positive HER2 status in patients with gastro-oesophageal adenocarcinoma and brain metastasis involvement was higher than expected., Her2 and Ki67 expression predicts recurrence of ductal carcinoma in situ., factor, Three factor model revealed significant gene-gene interaction for PDGFB +286A>G, PDGFB +1135A>C and HER2 Ile165Val SNPs with GBC. Protein-protein interaction showed significant association of PDGFB and HER2 with EGFR receptor signaling pathway., Salivary Her2/neu levels were found to be significantly high in oral cancer., HER2 mutations were identified as the only driver mutation in a significant proportion of solid cancers. Evaluation of anti-HER2 therapies in nonamplified, HER2-mutated cancers is warranted., HER2 rs1058808 and rs2517956 polymorphisms are associated with its protein expression in breast cancer, p-rpS6 is a robust post-treatment indicator of HER2 pathway-targeted therapy resistance, ErbB2 and EGFR have previously been considered as undruggable targets for CART cells., Data show that dual epidermal growth factor receptor 2 HER2/phosphatidylinositol 3-kinase PIK3CA blockade may be a drug therapy for uterine serous carcinoma (USC) with HER2 gene amplification and mutated wild-type PIK3CA resistant to chemotherapy., Data indicate that high proto-oncogene protein HER-2 (HER2) and low estrogen receptor alpha (ESR1) mRNA levels are required for achieving trastuzumab response., findings demonstrate that Her2+/+ mice, similar to Pds5b-/- mice, are embryonic lethal and confirm the necessity for Pds5b in embryonic development, Data showthat erbB-2 receptor protein-tyrosine kinase (HER2) represents an oncogene in ovarian cancer, and suggest that targeting this tyrosine kinase with T-DM1 may be therapeutically effective, especially in ovarian tumors with high content of HER2., 18F-fluorodeoxyglucose (FDG) PET/CT after two cycles of neoadjuvant therapy may predict response in HER2-negative, but not in HER2-positive breast cancer., ER negative breast cancer showed different expression of sarcosine metabolism related proteins according to AR and HER-2 status., HER2 are highly expressed, and HER2 positivity could be considered as a significant biomarker of poor prognosis in molecular apocrine breast cancer., Data suggest that the association between ER, PR and HER-2/neu is age-related., HER2 and EGFR gene copy number gains may play an important role in the progression of carcinoma ex pleomorphic adenoma, in particular ductal-type CXPAs., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, SRSF3 and hnRNP H1 are the first splicing factors identified which regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling., Results demonstrate that acquired resistance of colorectal tumour cells to treatment with anti-EGFR mAb ICR62 is accompanied by an increased level of cell surface EGFR, and upregulation of phosphorylated HER-2 and HER-3 proteins., Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor., HER2 mutations are associated with refractory metastatic breast cancers., CORRELATION BETWEEN CLINICAL PATHOLOGY OF LUMINAL B BREAST CANCER AND DETERMINATION OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER2 EXPRESSION COMBINED WITH NUCLEAR MORPHOLOGY., HER2 expression rate increased in patients diagnosed with esophageal carcinoma.No correlation was found in patients survival., Uni- and multivariate analyses included age, tumor size, grade, ER, and Her2; in multivariate analysis, MammaPrint reached near-significance (HR 3.01; p 0.08)., Positive HER2 expression is associated with trastuzumab benefit in breast cancer., These results are encouraging for further development of these bsRICs for dual-receptor-targeted radioimmunotherapy of breast cancer coexpressing HER2 and EGFR, including trastuzumab-resistant tumors, It blocked activation of EGFR, HER2 and downstream Akt and Erk., critical pathophysiologic event in the evolution of HER2-amplified cancers is the loss of the input signals that normally drive TORC2 signaling, repositioning it under Akt dependency, and fundamentally altering the role of HER3, loss of FOXO1 promotes GC growth and metastasis by upregulating HER2 expression., clinically sizeable 5% fraction of KRAS wild-type colorectal cancer patients was found to be ERBB2-positive according to the colorectal cancer-specific ERBB2 scoring criteria, FcgammaRIIIA/FcgammaRIIA gene polymorphisms and HER-2 may have a role in antibody-dependent cellular cytotoxicity and clinical response to trastuzumab in breast cancer, MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients., we provide a wide-ranging overview of potential biomarkers capable of stratifying patients regarding their response to trastuzumab includING HER2 amplification--{REVIEW}, To predict HER2 status precisely in gastric carcinoma resection specimens, at least 4 biopsy fragments containing tumor cells are required., HER2 gene rs1136201 and rs1058808 polymorphisms and haplotype C-T-G-G may be related to osteosarcoma susceptibility in Chinese Han population, High levels of stromal tumor infiltrating lymphocytes were associated with lack of trastuzumab therapy benefit in early stage HER2-positive breast cancer., Results suggest reclassification of HER-2 proto-oncogene protein (cHER2+) tumors based on the spectrum of molecular breast cancer subtypes., Combined treatment with GEM and T-DM1 might confer a potent therapeutic modality against PDA as a result of GEM-mediated HER2 up-regulation., The KIT and PDGFRB mutations were predicted to be pathogenic using in silico analysis, whereas the ERBB2 mutation was predicted to be benign...the patient was treated with pazopanib and achieved a partial response that lasted for 7.5 months, HER2 genetic alteration in non-small cell lung cancer is associated with the treatment outcome with tyrosine kinase inhibitors. [review], The reduction in Phosphorylated-HER2 (P-HER2) and P-EGFR in the ex vivo-treated biopsy demonstrated good correlation with the in vivo response at day 10., findings newly identify a physiological function of the NRG1-ErbB2-ErbB3 axis in trophoblast survival during human placental development., Our study indicates that apigenin induces apoptosis through inhibition of STAT3 signalling and could serve as a useful compound to prevent or treat HER2-overexpressing breast cancer., only lapatinib enhanced trastuzumab-mediated ADCC via the upregulation of HER2 expression in MPM cells, suggesting that sequential combination of lapatinib and trastuzumab may be a promising strategy for MPM treatment., HER2 Codon 655 (Ile/Val) Polymorphism is not associated with Breast Cancer., HER2 missense mutations have distinct effects on oncogenic signaling and migration., E2F3 silencing decreases Her2-positive mammary tumor growth by reducing percentage of cells undergoing mitosis., Data indicate that the combination with the HER-2 proto-oncogene protein (HER2) inhibitor lapatinib and the inhibition of mTOR serine-threonine kinase (mTor) affords the highest degree of synergy., In addition HER2 discordance was more likely amongst different tumour foci if these arose in distinct and separate areas of DCIS, series confirms a high concordance rate of 95%, supporting that testing of primary tumours and metastases is equally valid and providing clinical rationale for the addition of anti-HER2 therapy in HER2+ disseminated disease, Continued use of trastuzumab in HER2(+) PTEN(-) cells increased the frequency of cancer stem cells., indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis, Our data suggest that b2-AR may be a new useful biomarker for predicting prognosis in Her2-positive breast cancer and may also be a promising selective therapeutic target for the aggressive subtype of breast cancer., For key genes ERBB2 and ESR1, we demonstrate that overexpression is linked to the production of highly modified and truncated splice variants in tumours, but not controls, correlated with tumour subtype, Study demonstrated that NAMPT, VEGF and HER2 were overexpressed in breast tumors as well as in the serum and their circulating levels declined after tumor removal, suggesting a clinical application of this triplet as biomarker for breast cancer diagnosis., Data suggest that NDRG1 down-regulates expression and activation of HER1/EGFR, HER2/ERBB2, and HER3/ERBB3 in response to epidermal growth factor (EGF) ligand in pancreatic/colonic neoplasm cells., Left ventricular dysfunction was low in node negative ERBB2 breast cancer patients receiving weekly paclitaxel/trastuzumab., Estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 samples with high-methylation risk score had the worst 5-year survival rate and overall survival time., Analysis of patients with ER-/PgR+/HER2- breast cancers showed that this subtype exhibited an aggressive behavior compared to triple negative breast cancers., The authors identified an alternative HER2 transmembrane domain dimerization coupled with self-association of membrane-embedded cytoplasmic juxtamembrane region, effectively inhibiting the receptor kinase activity., Report use of protein kinase inhibitors in treating HER2-positive breast cancer with progressive brain metastases., Report quantitative real-time polymerase chain reaction is an alternative method for the detection of HER-2 amplification in formalin-fixed paraffin-embedded breast cancer samples., In patients with advanced cancer of gastric carcinomas and gastroesophageal junction, HER2-neu overexpression was more associated with the intestinal cancer subtype., Data show that droplet digital PCR (ddPCR) has the advantage of automation and allows levels of epidermal growth factor receptor 2 (HER2) amplification to be easily evaluated in large numbers of samples to define HER2 status., Incidence of cardiotoxicity among cohort of Italian women treated with trastuzumab for HER2-positive MBC appeared higher than that reported in RCTs, particularly in elder patients., Blocked autophagy in response to inhibitors of HER2., variation within the codon 655 of HER2 does not alter the Breast Cancer risk in Caucasian Austrian women, MSM decreased the ability of STAT5b to bind the promoter of the HER2 gene., NRG1 promotes the proliferation and migration of coronary artery smooth muscle cells by enhancing the phosphorylation of ErbB2, ErbB3 and ErbB4., positive expression of p53 and Bcl-2 and amplification of c-erb-B2 gene were detected in transitional cell carcinoma and squamous cell carcinoma and they were correlated with urinary bladder cancer advanced tumor grades, This suggests that a high HER2 FISH ratio is a potential indicator for a high pathologic complete response rate and a better prognosis when patients are treated with neoadjuvant systemic treatment-trastuzumab ., Increased expression of HER2 was linked to poor outcome in lung cancer patients., A higher proportion of HER2-overexpressing cases experienced recurrence, but the difference was not significant, obesity-associated systemic factors suppress ERbeta expression in breast cancer cells via a HER2-mediated pathway, PMCA2 interacts with HER2 in specific actin-rich membrane domains., Assessment of the HER2 status of biopsy tissues could predict the status of the whole tumor; however, a proportion of these cases may be discordant because of intratumoral heterogeneity, The combination of MM-302 and trastuzumab induced synergistic antitumor activity in HER2-overexpressing xenograft models of breast and gastric cancer., Studies indicate that overexpression of the HER2 proto-oncogene protein (HER2) may be found without the amplification of the HER2 gene, and HER2 gene amplification can occur without overexpression of the HER2 protein., Report link between the Ala1170Pro SNP and HER2 positivity and between HER2 overexpression and loss of heterozygosity in breast cancer., FGFR1 protein expression may be a biomarker of ER-positive/HER2-negative primary breast cancer with possible resistance to standard treatment, and may be a useful tool to identify more specific patients who would benefit from FGFR-1 targeted therapy., Photoimmunotherapy in combination with 5-FU resulted in enhanced antitumor effects compared to PIT alone for HER2-expressing human gastric cancer in vitro and in vivo, the MapQuanttrade mark assay, based on mRNA expression assay, provides an objective and quantitative assessment of Estrogen receptor, Progesterone receptor and HER2 status in invasive breast cancer., HER2 signaling promotes breast cancer cell proliferation through regulation of E2F1-driven DNA metabolism., while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 and ErbB4 expression., TOM1L1 enhances ERBB2-induced cell invasiveness by promoting invadopodia formation and MT1-MMP trafficking to the plasma membrane., Our data demonstrate a critical role of Mcl-1 in Her2-positive BC cell survival under hypoxic conditions and provide the preclinical framework for the therapeutic use of novel Mcl-1- targeting agents to improve patient outcome in breast cancer ., no clinical significance of serum levels in ovarian cancer, In a transgenic model of breast cancer, Pten suppression using a tetracycline-regulatable shRNA cooperates with HER2/neu, leading to aggressive and metastatic disease with elevated signaling through PI3K and, surprisingly, the MAPK pathway., This study showed a significant grade of discordance of the HER2 status between primary tumors and disseminated tumor cells in the bone marrow of a relevant subgroup of patients., The use of HER2 gene copy number, and the so-called chromosome 17 polysomy was ascertained to cause a statistically significant increase in HER2-positive cases from 25 to 42., beta3-alphaC deletions are activating mutations in HER2. HER2 deltaLRENT is an activating deletion primarily through increased phosphorylation of its dimerization partner. These deletions are resistant to the alphaC 'Out' inhibitor lapatinib., measurements comprising the receptors EGFR, ERBB3 (HER3), and the cyclin-dependent kinase inhibitor p27 (CDKN1B) was found to accurately predict dependence on PI3K/AKT vs. MAPK/ERK signaling axes in HER2+ cancers, HER2 amplification, age, and grade were not significantly different between ER-/PR+ and double receptor negative groups, HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study, Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma, p95HER2(truncated HER2) was correlated with trastuzumab resistance, but it was not an independent factor of trastuzumab resistance.,
OFFICIAL_GENE_SYMBOL ERBB2,
OMIM_DISEASE Glioblastoma, somatic, Adenocarcinoma of lung, somatic, Gastric cancer, somatic, Ovarian cancer, somatic,,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas., disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC)., disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung., disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome., function:Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin., online information:ERBB2 entry, polymorphism:There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012., PTM:Ligand-binding increases phosphorylation on tyrosine residues., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily., similarity:Contains 1 protein kinase domain., subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.,
erb-b2 receptor tyrosine kinase 3(ERBB3) erb-b2 receptor tyrosine kinase 3(ERBB3) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q13,
ENSEMBL_GENE_ID ENSG00000065361,
GENERIF_SUMMARY AP-2gamma is important in the regulation of Erbb-3 expression in human mammary epithelial and lung fibroblast cells, Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers, Role of the N-terminus of epidermal growth factor in binding studied by phage display., structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains, Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of this epidermal growth factor receptor family member, role of overexpression in lung cancer development in conjunction with erb-B-2 overexpression, the ErbB-3 affinity of a ligand determines whether it can form only ErbB-2/ErbB-3 complexes or also ErbB-3 homodimers., Activation of ErbB3 pathway may contribute to the development of dedifferentiated carcinomas, Expression of epidermal growth factor receptor, erbB2, and erbB3, but not erbB4, was detected throughout the epidermis. Labeling for erbB2 and erbB3 accentuated in upper spinous layers, These results suggest that ErbB3 expression alone does not uniquely confer IFN-alpha growth responsiveness, but instead may amplify proliferation rates in MM cells that have acquired atypical expression of this receptor., ErbB2/ErbB3 dimer functions as an oncogenic unit to drive breast tumor cell proliferation., ERBB2 and ERBB3 expression is inhibited by quercetin, resulting in decreased autophosphorylation and cell growth, Overexpression of ErbB3 is associated with transitional cell carcinoma of the bladder, ErbB3 is involved in IFN-alpha-induced proliferation of myeloma cells., heterodimer formation with heregulin regulates erbB2 receptor, This review summarizes evidence of defective expression of erbB3 in the prefrontal cortex of schizophrenic patients, implicating erbB3 involvement in the pathogenesis of schizophrenia., ErbB3 is an obligate heterodimerization partner because of its inability to homodimerize., before extracellular signal-regulated kinase activation and aquaporin synthesis, the membrane-bound prohormone neuregulin 1-beta is cleaved and binds to human epidermal growth factor receptor 3, calculated binding free energies between the N-SH2 domain of PI-3 kinase and P-peptides generated by erbb3 showed excellent qualitative agreement with SPR data with a correlation coefficient of 0.91, most of the ErbB3-ECD on the cell surface is apparently kept in an open conformation through oligomerization, ErbB3 proteins are promising targets for therapy, and siRNAs may be useful for this purpose., Potential of anti-HER3 antibodies for the therapy of breast cancer and other malignancies characterized by overexpression of HER3., Inhibition of HER2/HER3 signaling protects against pulmonary fibrosis and improves survival., Transcriptional activity of eztrogen receptor beta was altered in a manner similar to ERalpha by activation of ErbB2/ErbB3., Cell proliferation was increased when ErbB2 and ErbB3 were both overexpressed., the most notable changes consisted in the overexpression of ErbB3 by Schwann cells of nerves from Charcot-Marie-tooth disease type 1A patients, ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer, HER2 overexpression was the best single predictive marker, but combinations of HER3, HER2 markers provided additional predictive information., The high frequency of ErbB3 nuclear localization in hormone-refractory tissues indicates that ErbB3 warrants further study to understand its association with prostate cancer disease progression., HER3 and HER4 has been related to a favourable prognosis in bladder cancer., Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3, ErbB3 has six binding sites for PI3K. All three Y-E-Y motifs contain a binding site for PI3K at the first tyrosine residue. 2 motifs contain a binding site for Grb2 at the second tyrosine., the neuregulin/ERBB3 signaling pathway is constitutively activated in clear cell sarcoma of soft tissue, Sox10-regulated overexpression of ErbB3 may be driving growth in pilocytic astrocytoma., failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself, enhanced signaling from the HER2/neu-HER3 pathway has a role in growth of tumors treated with fulvestrant in the presence of physiologic estradiol, Neuregulin 1-induced protein stability cascade involving USP8 and Nrdp1 mediates the down-regulation of ErbB3, there were no significant association between the polymorphisms or haplotypes of ERBB3 and schizophrenia; study shows that ERBB3 does not play a major role in conferring susceptibility to schizophrenia in the Japanese population, findings show that amplification of MET causes gefitinib resistance in lung cancer by driving ERBB3 (HER3)-dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors, HER3 signaling pathway plays an important role in the biological behavior of certain non-small cell lung cancers., Increased expression of erbB3 may play an additional role in non-small-cell lung carcinomas especially in female, nonsmoker, adenocarcinoma, and with EGFR gene mutation., Nuclear localization of ErbB-3 may aid prostate cancer cell survival during androgen ablation and progression of prostate cancer in bone., p45-sErbB3 may mediate the bidirectional interactions between prostate cancer cells and bone via osteonectin, These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities., analysis of EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases, Ligand-induced structural transitions in ERBB3 extracellular domains are reported., Lethal congenital contractural syndrome type 2 is caused by aberrant splicing of ERBB3, which leads to a predicted truncated protein., results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands, ErbB3 and ErbB4 genes play different roles in carcinogenesis and development, and relate to the reccurrence of carcinoma., ErbB-3 expression was associated with better prognosis in invasive ductal carcinomas of the breast., N-glycosylation controls ErbB signaling by various mechanisms., disruption of surface HSP90/HER-2 interaction leads to inhibition of heregulin-induced HER-2-HER-3 heterodimer formation, reduced HER-2 phosphorylation, and impaired downstream kinase signaling., Strong HER3 staining was found in 26.7% of both the primary tumors and the corresponding metastases., HER3 gene amplification showed a univariate negative impact on disease-free survival, In human uterine leiomyomas, ERBB3 were also overexpressed., the alpha6beta4 integrin strongly influence Akt phosphorylation through ErbB-3 protein regulation, Elevated EGFR, Her2, and Erbb3 phosphotyrosine is dependent on FGFR2; shRNA to Erbb3 resulted in a loss of proliferation in gastric neoplasms., HRG-induced activation of ErbB3 via EGFR promotes tumor growth and metastasis of melanoma cells, Her3 showed significantly increased expression in differentiated thyroid cancer and correlated with lymph node metastasis,tumor type,and higher N stage, The apparent correlation between higher sErbB3 levels and longer time to bone metastasis suggests that sErbB3 participates in progression in bone of prostate cancer., Datas show that transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab., inhibition of HER3 may be more clinically relevant than inhibition of EGFR in HER2-amplified breast cancer and adding pertuzumab to trastuzumab may augment therapeutic benefit by blocking HER2/HER3 signaling, Our results provide novel insights into the role of HER3 in melanoma and point out new possibilities for therapeutic intervention, Akt1 activation accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3, Patients with HER2 nonamplified and HER1 through HER3-negative tumors showed significantly increased relapse-free and overall survival rates when treated with epirubucin-CMF., Protein kinase A-mediated gating of neuregulin-dependent ErbB2-ErbB3 activation has a role in the synergistic action of cAMP on Schwann cell proliferation, These data support a role for EBP1 in the development of hormone-refractory prostate cancer., ERBB3 receptors are apparently segregated from ERBB2 receptors in their resting state, and both ligand-activated ERBB3 and ERBB2 do not share the same microenvironment as inactive ERBB3, HER3 and HER4 gene transcription is associated with better prognosis in high-risk early breast cancer., HER3 overexpression is strongly associated with tumor progression and poor prognosis of patients with gastric cancer, The biological function and clinical implications of HRG, HER-3 and HER-4 in breast cancers negative/low expression of HER-2 remain unclear, repression of MUC4 expression resulted in diminution of the phosphorylation of ErbB2 and ErbB3, expression of ErbB3 and ErbB4 may identify a colorectal cancer subgroup with stage II and III colorectal cancer at higher risk of recurrence., Results showed that 45.8% of typical carcinoid and 28.6% of atypical carcinoid tumors express EGFR, 100% of the tumors lack expression of ErbB2, and 100% have moderate to intense staining for ErbB3 and ErbB4., Current data relating to the prognostic significance of HER3 and 4 receptors, as well as their impact on the activity of HER-targeting therapies in patients with breast cancer., Data demonstrate a more stable binding of heregulin to cells co-expressing HER3 and HER2 than those expressing HER3 alone., Data show that aberrant expression of ErbB2, ErbB3 and ErbB4 in the two resistant cell lines, suggesting the existence of an autocrine loop leading to constitutive activation of MAPK and PI3K/Akt survival pathways., Non-small cell lung carcinoma brain metastases have some significant differences in HER family receptor-related abnormalities from primary lung tumors., Nuclear Y-box binding protein-1 is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer., Results show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory and proliferative cellular characteristics., HER3 mRNA was down-reg'd after stim'n with heregulin-beta1 and EGF in ovarian cancer cell lines either growth sensitive or growth resistant to pertuzumab. Pertuzumab reversed the down-reg'n and the magnitude of this corr'd with pertuzumab sensitivity., Heregulin might affect colon cancer growth by regulating VEGF secretion via the erbB3 signaling pathway through autocrine and paracrine mechanisms., Observed weak transactivation is uni-directional where stimulation of EGFR leads to HER3 activation whereas HER3 stimulation does not activate the EGFR., We investigated the ERBB3 gene given the putative functional nature of the gene and population heterogeneity between Asian and Caucasian. Scottish case and control samples were sequenced with four SNPs (rs705708 at intron 15., EGFR mutation combined with HER2/3 expression is a significant predictor for gefitinib efficacy on Chinese patients with advanced non-small cell lung cancer., These results suggest that P2Y(2)R activation in salivary gland cells promotes the formation of EGFR/ErbB3 heterodimers and metalloprotease-dependent neuregulin 1 release, resulting in the activation of both EGFR and ErbB3., Results suggest that trastuzumab resistance in breast cancer might be overcome by therapeutic strategies that jointly target erbB3, erbB2, and IGF-IR., HER-3 expression is correlated with better prognosis in neuroendocrine cancer, ErbB3 has a role in cell proliferation in ovarian cancer., ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation., erbB3 immunoreactivity was prominent in CD133-positive putative tumor stem cells., The study emphasizes the central role of EGFR in epidermal renewal and demonstrates that HRG-activated HER3 contributes to the outgrowth process of epidermis in vitro., observations suggest that PI3K mutants enhance HER2-mediated transformation by amplifying the HER3 ligand-induced signaling output of the ErbB network, Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes, Observations point to a model of CRPC development in which progression of PCa to castration resistance is associated with the inability of AR to transcriptionally regulate Nrdp1, and predict that inhibition of ErbB3 during AW may impair CRPC development., Over-expression of ErbB2 by transient transfection resulted in partial separation of the receptors by relocalization of ErbB2, but not ErbB3, to the apical surface, as shown by biotinylation of the apical or basolateral surfaces, Data show that the brain metastases over-expressed one or more members of the HER family and in particular HER3 was significantly over-expressed relative to matched primary tumors., Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG., Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors., Data show that ErbB3 appears to be critically involved in EGFR signaling as evidenced by its profound effect on cellular proliferation and its ability to influence response to EGFR-targeted therapy., results show that ZNF217 regulates ErbB3 expression, Results indicate that ERBB3 plays a critical role in determining APC function and potentially T1D pathogenesis., direct NRG1-integrin interaction mediates integrin-ErbB3 cross-talk and that alpha6beta4 plays a major role in NRG-ErbB3 signaling in these cancer cells., HER3 mRNA levels may be a biomarker for active ligand-induced HER2-HER3 signaling, with low HER3 mRNA levels correlated with clinical benefit from the HER2-HER3 dimerization inhibitor pertuzumab., Data show that integrin alpha(6)beta(4) interacts with ErbB3 but not with ErbB1, ErbB2 or ErbB4, and enhances the heregulin-induced, ErbB3/ErbB2 heterodimer-mediated DNA synthesis, but not cell motility, in A549 cells., Data show that blockade of amphiregulin suppressed the activities of EGFR, HER3, and Akt and the expression of amphiregulin itself., quantification of EGFR and HER3 mRNA expression in pretreatment biopsies may be useful to identify patients who are at risk of developing metastases, The data demonstrate that sclerostin functions in part, by modulating the activity of erbB-3., HER3 seems not to be of such interest for radionuclide therapy in colorectal carcinoma due to mainly expression in the cytoplasm, HER receptor family plays an important role in embryonic development and in pathogenesis and progression of neuroblastic tumors., The constitutive activation of ERBB3-dependent signaling via the NRG1/ERBB3 autocrine loop plays a crucial role in the regulation of cell motility and invasion, which contribute to intrahepatic metastasis and early recurrence of hepatocellular carcinoma., HER overexpression orchestrates broad changes in the tumor microenvironment by altering the secretion of a diverse variety of biologically active proteins., therapeutic inhibitors of HER3 should be used in combination with HER2 inhibitors and PI3K pathway inhibitors in patients with HER2- and PI3K-dependent cancers, We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues., 148 Penile squamous cell carcinoma were microarrayed and immunostained for phosphorylated EGFR (pEGFR), HER2, HER3, HER4, phosphorylated Akt (pAkt), Akt1 and PTEN proteins., ARF6 can affect ErbB-3 nuclear localization in prostate cancer cells., HER3 is frequently localized solely in the cell nuclei in UM and as such it predicts a more favorable overall survival., Data demonstrate that Nrdp1 preferentially associates with the nascent form of ErbB3 to accelerate its degradation, and that the two proteins colocalize at the endoplasmic reticulum., demonstrate the therapeutic potential of this approach by showing that bivalent NRG (NN) can bias signaling in HER3-expressing cancer cells, resulting in some cases in decreased migration, inhibited proliferation, and increased apoptosis, In situ detection of HER2 and HER2, HER3 expression was significantly related to worse survival in gastric cancer., Results indicate that stimulation of the early metastatic steps of motility and invasion by ErbB3 requires activation of the PI3-kinase pathway by the ErbB3 receptor., DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib., Stromal (Cancer-Associated Fibroblasts)CAF-secreted NRG-1 stimulates ErbB3/AKT signalling and promotes pancreatic cancer cell tumourigenesis, providing a mechanism that may contribute to PDAC resistance to anti-EGFR therapy., Membranous Her3 expression is strongly associated with poor prognosis of patients with head and neck squamous cell carcinoma., sERBB3 may have a role in portal-vein invasion and extrahepatic metastasis of hepatocellular carcinoma, erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines, The anti-ErbB3 antibodies modulate the growth rate of cancer cells of different origins., Findings show that the bispecific antibody MM-111 forms a trimeric complex with ErbB2 and ErbB3, effectively inhibiting ErbB3 signaling and showing antitumor activity in preclinical models that is dependent on ErbB2 overexpression., ErbB3(80 kDa) increases the transcription of proliferative genes even when the cytoplasmic pathways are not activated., Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination., results indicate that downregulation of ErbB3 induced by Wnt3a contributes to Wnt3a-induced early osteoblast differentiation of MSCs through increased canonical Wnt/beta-catenin signaling and decreased Src signaling, Signaling via the HER2/HER3 pathway in breast carcinoma cell lines may lead to enhanced natural killer cell (NKG2D)-histocompatibility class I-related chains A/B (MICA/B) recognition by NK cells and T cells., Immunoreactivity for erbB1 was strong and that for erbB2 and 3 was moderate, while that for erbB4 was faint in nasal mucosa chronic rhinitis., ErbB3 is endocytosed in the absence of added ligand., Data show that miR-22 inhibited the expression of ErbB3 through post-transcriptional regulation via binding to ErbB3 3' untranslated regions (3'-UTR)., Mutation of this amino acid led to increased ERBB receptor activation and upregulation of the ERBB3/PI3K/AKT signaling pathway, which was no longer responsive to MEK inhibition, This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma., HER3 expression was significantly associated with patients who have post-menopausal high tumour grade progesterone receptor negativity., Higher order complexes of nonoverexpressed ERBB receptors are an integral and qualitatively distinct part of normal ERBB2/ERBB3 signaling., Binding of L1CAM to erbB enhances its response to neuregulins., Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer., the highly regulated nature of HER3 and its role as a dynamic signalling hub linking HER family oncogenes with downstream PI3K/Akt pathway signalling., In ER-positive breast cancer, correlations were found in the expression of activated HER-receptors (pHER1, pHER2, pHER3), indicating a potential role of HER1 and HER3 in the activation of HER2. HER3 expression was not associated with prognosis., We observed the reaction kinetics between fluorescently labeled single HRG molecules and ErbB3/B4 on the surfaces of MCF-7 human breast cancer cells., intracellular domains play a crucial role in HER3's function as an allosteric activator and its role in downstream signaling, ErbB3 might be considered as a biomarker for major depressive disorder (MDD). ErbB3 but not fibroblast growth factor receptor (Fgfr)1 mRNA levels are reduced in leukocytes of MDD patients compared to healthy subjects., In extrahepatic cholangiocarcinoma HER3 overexpression is correlated with decreased patient survival, suggesting that HER3 constitutes a prognostic factor., The -276 C/T polymorphism was associated with the risk of lung cancer in a recessive model of never-smokers. Interestingly, the T allele conferred significantly lower promoter activity by 32% and 33% than the C allele in H2009 and H358 cell lines., Our findings demonstrate that HER2 and HER3 co-expression induces IL8 autocrine signaling, leading to the invasion of mammary cells., Low expression of ERBB3 is associated with neuroblastoma progression., Results suggest a possible participation of erbB1-4 and claudin-1 in tissue remodelling in chronic hypertrophic rhinitis., These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation., the neuregulin 1-HER axis is a key mediator of hyperglycemic memory effects in breast cancer, A direct correlation between basal HER3 expression and sensitivity to elisidepsin is observed; moreover, modulation of HER3 expression levels in different cancer cell lines alters their sensitivities to the drug, HER3 pathway activation is associated with lung cancer., The present data suggest that ErbB2, ErbB3, and ErbB4 genes may have a role in bladder cancer tumorigenesis., Data suggest that ErbB receptors (ERBB2, ERBB3, and ERBB4) are expressed in most endometrial cancers; expression of ErbB receptors appears to be related to poor prognosis; dismal outcomes correlate with cancers positive for all three ErbB receptors., high-level expression of HRG is associated with constitutive activation of HER3 in SCCHN and thus defines an actionable biomarker for interventions targeting HER3., an NRG1-ERBB3-ERBB2 signaling unit operates in melanoma cells where it promotes growth and survival., the suppressive role of Necl-2 in the HRG-induced ErbB2/ErbB3 signaling is regulated by miR-199a at least through the reduction of the ST6GAL1-catalyzed sialylation of Necl-2, ErbB3 is involved in bone tumor growth and ErbB3 expression in human osteosarcoma correlates with tumor grade, upregulation of ERBB3 is involved in melanoma adapting to RAF/MEK inhibitors through FOXD3, results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly, beta4 integrin rs8669 genotyping may help to identify a subgroup of HER-3-negative, K-RAS wild-type colorectal cancer patients who are more likely to benefit from anti-EGFR treatment., This review article surveyed human cancers and identified recurrent somatic ERBB3 mutations and show that these mutations are transforming., Altogether the results indicate that pertuzumab can be a valuable therapeutic agent not only in cancers overexpressing ErbB2 but also in cancers co-expressing ErbB2 and ErbB3, EGFR interacts with Grb2 in both constitutive and EGF-dependent manners, whereas the HER3-Grb2 interaction requires the heteromerization of EGFR and HER3., Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability., Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation., Heregulin binding was prevented by RG7116 at concentrations more than 1 nmol/L as was nearly complete inhibition of HER3 heterodimerization., results suggest that IGF-1R and HER3 differentially regulate trastuzumab resistance and could be promising targets for trastuzumab therapy in ovarian cancer, ERBB3 is a clear-cut marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile., Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface., Studies indicate high percentage of HER3 positivity in patients with pancreatic cancer, and a high prevalence of PI3K and AKT activation as well, suggesting responsiveness to erlotinib and validating the idea of targeting therapy., Our data suggest that HRG-beta1 and ErbB3 induce epithelial-mesenchymal transition, cancer cell migration and invasion in breast cancer cells, These analyses identified a bipartite region of 34 (B) and 27 (B) amino acids in length that conferred the majority of HER3's transactivation potential., constructed an integrated mathematical model of HER activation and trafficking. Studied HER phosphorylation and abundance data collected in a panel of human mammary epithelial cells expressing varying levels of EGFR/HER1, HER2 and HER3., In tumours from postmenopausal women harbouring normal HER2 gene copy numbers, we found HER2 and HER4, but HER3 levels in particular, to be elevated compared to controls, HER-3 overexpression is associated with breast cancer., Analysis of HER3 expression in tumor samples indicated that radiation treatment activated HER3 in vivo and that U3-1287/AMG888 could abrogate this activation., Upregulation of ErbB3 in luminal breast cancer cells promotes growth, survival, and resistance to fulvestrant., all pairings of the EGF receptor, ErbB2, and ErbB3 form ligand-independent dimers/oligomers., MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells., An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models., HER-3 has become a focus of concern in the HER family and has gained significant attention in the search for cancer treatment., the N-glycan-deleted mutant of sErbB3 suppresses heregulin signaling via ErbB3-containing heterodimers more effectively than the wild type., EBRR3 p.Val104Met and p.Val104Leu mutations that are recurrent and might be targeted in cancer therapy is rarely mutated in hematologic neoplasia and may not be therapeutically targeted in these neoplasia, Data indicate that the blockade of IGF-I receptor (IGF-IR) and ErbB3 receptor (ErbB3) survival pathways and downstream resistance mechanisms was achieved with MM-141., HER3 expression in the tumour was an independent prognostic factor, where a high HER3 expression was associated with worse clinical outcome. There was a correlation in HER3 expression between primary tumour and corresponding lymph node metastases., Patients who had negative HER3 staining (62.4%) had a better progression-free survival., Studies suggest that concomitant inhibition of erbB3 receptor is required to overcome the resistance and to effectively treat cancers., A high MUC1 expression was associated with a favourable prognosis in patients with bladder cancer when the expression of HER3 was also high. This suggests an involvement of HER3 in MUC1 function in bladder cancer., Coiled-coil domain deletion abrogates Nrdp1 oligomerization and suppresses Nrdp1 but not ErbB3 ubiquitination and degradation., Her3 promotes proliferation, survival and migration of human gastric cancer mediated by PI3K/AKT signaling pathway, Results demonstrated that NEDD4 is a novel interaction partner of HER3 and the C-terminal tail of HER3 interacts with the WW domains of NEDD4., Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer., Affinity-purified bispecific Affibody molecules, targeting HER2 and HER3., the ErbB3/4 ligand heregulin (HRG) reduced both ErbB2 and ErbB3 mRNA and protein levels in human breast cancer cell lines., We show for the first time the presence of HER2/HER3 heterodimers and the loss of p21 expression in HER2+ breast cancer predicts a significantly poorer outcome when submitted to adjuvant trastuzumab, Depletion of either flotillin-1 or flotillin-2 resulted in downregulation of ErbB3 and a selective reduction of ErbB2-ErbB3 receptor complexes., ErbB3, ErbB4, and MET showed marked expression in 76%, 98%, and 96% of ovarian carcinoma cases., These data support the concept that activation of ERBB family members is sufficient to bypass dependency on FGFR3 and suggest that concurrent inhibition of these two pathways may be desirable when targeting FGFR3-dependent cancers., This study confirmed presence of somatic mutations of ERBB3 in gastric cancers (GC) and colorectal cancers (CRC) and increased intensity of pERBB3, an activated ERBB3, in GC and CRC, and that such increased intensity was accompanied by ERBB3 mutations., Data show that proto-oncogene protein ERBB3 knockdown resulted in cell cycle arrest and activation of Bak and Bax-dependent apoptosis., MET, HER3, IGF1R, and INSR pathways activation represent novel mechanism underlying lapatinib unresponsiveness in HER2+ gastric cancer. Combination strategy may be recommended in treating patients with HER2+ gastric cancer with these pathways activation, HER2/HER3 co-overexpression is significantly associated with impaired survival from diagnosis of metastatic disease in patients with HER2-positive metastatic breast cancer., Findings suggest that deficient HER3 expression plays an important role in gefitinib sensitivity in poorly-differentiated colorectal cancer cells., miRNA-450b-3p as a new tumor repressor which downregulation with concurrent overexpression of HER3 may serve as a prognostic biomarker for poor overall survival in breast cancer patients., Overexpression and gene amplification of HER3 was found in biliary tract carcinomas., Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression, Findings provide clues regarding the role of the miR-143/145 cluster as a tumor suppressor in breast cancer through the inhibition of ERBB3 translation., NTS/NTSR1 complex enhances breast tumor aggressiveness via EGFR/HER2/HER3 pathway., Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib., HER3 knock down decreases cell proliferation preferentially in PIK3CA kinase domain mutation (H1047R) cells., Her2/Her3 and Met/Her3 were verified in human GC., REVIEW in regulation of HER3 signaling in cancer, Phosphorylated ErbB1-4 and heregulin contribute to poorer patient prognosis in CRC. This heregulin-ErbB family member autocrine loop may be a candidate for targeted treatment of CRC., Cancer-associated HER3 mutations enhanced the allosteric activator function of HER3 by redesigning local interactions at the dimerization interface., Data show that the combination of PI3 kinase inhibitors with ErbB receptors HER2/HER3 targeting antibodies may constitute a promising therapeutic strategy for prostate cancer., ErbB2 and ErbB3 homodimers are endocytosis deficient owing to the lack of endocytic codes. Interestingly, EGFR-ErbB2 or EGFR-ErbB3 heterodimers are also endocytosis deficient, GAB adaptor proteins play a role in ERBB3-independent activation of the PI3K pathway by mutant EGFR in EGFR-mutant human cell lines., For selected miRNAs, namely miR-149, miR-148b, miR-326, and miR-520a-3p, we demonstrate the simultaneous downregulation of the ErbB3 receptor and multiple downstream signaling molecules., A major conformational change of HER3 during its activation is induced by a complex sequential HRG1beta docking mode., HER3 is correlated with the malignant biological behaviour of gastric cancer. Expression of HER3 is a significant predictor of poor survival in GC., Although not an independent prognostic factor for overall survival, HER3 overexpression was associated with several favourable prognostic clinicopathologic parameters in colorectal cancer, activates YAP and stimulates cancer cell growth. Knockdown of ERBB3 or HBEGF eliminates YAP effects on cell growth and transformation, The ability of EBP1 to activate ErbB2 signaling pathways results in increased lapatinib sensitivity., Data (including data from SZ95 sebocyte cell line) suggest sebocytes abundantly express EGFR (epidermal growth factor receptor) with lower levels of ERBB2 and ERBB3; expression of these receptors appears coordinated with lipogenesis in specific ways., Using various assessment methods and patient populations, our results revealed that there was no significant correlation between ErbB3 expression and breast cancer survival. Meta-analysis., Data show that proto-oncogene protein HER-2 overexpression occurs in only 8% of patients with colorectal cancer (CRLM) but with 75% of cases proto-oncogene protein HER-3 is frequently overexpressed in CRLM., the EGFR and ErbB-3 heterodimerization, regarded as the origin of intracellular signaling pathways, was investigated., The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer., Dual blockade of EGFR and HER3 may enhance the targeted disruption of HER family signaling in these cancers both by blocking parallel and overlapping signaling pathways and potentially blocking the emergence of resistance., HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells, findings show that the local 3D tumor microenvironment can trigger reprograming and switching of ErbB family members and thereby influence ErbB3-driven tumor growth, Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells, Expression of total HER2, total HER3 were significantly elevated in HPV(+) HNSCC., ERa-dependent expression of LRIG1 dampens ErbB3 signaling in luminal breast cancer cells, and by blocking ERa activity with fulvestrant, LRIG1 is decreased thus permitting ErbB3 accumulation, enhanced ErbB3 signaling to cell survival pathways, both ErbB-2 and ErbB-3 receptors are expressed in colon cancer stem cells and NRG-1beta plays an important role in sustaining proliferation of both wild-type and BRAF-V600E mutated cells, Data indicate that high heregulin mRNA and high HER3 protein levels are independently correlated with poor overall survival in patients with oropharyngeal squamous cell carcinoma., these studies support the rationale to target the NRG1-ErbB3-ErbB2 axis as a novel treatment strategy in a subset of cutaneous melanomas., SNP in HER2 codon 655 and investigation of HER2 and HER3 expression could be helpful to outline the prognosis for patients with lung adenocarcinoma., Findings suggest that triple therapy directed against BRAF/MEK/ErbB3 may be able to provide durable control of BRAF mutated metastatic melanoma., Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt pathway and promoting erbB2-driven mammary/breast tumorigenesis., neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma, Using a new pyrosequencing assay, this study uncovers an E332E mutation affecting HER3 in retroperitoneal leiomyosarcoma clinical samples., Data show that cotreatment with anti-ERBB3 proto-oncogene protein antibody seribantumab and letrozole had increased antitumor activity., ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer., Results demonstrate that acquired resistance of colorectal tumour cells to treatment with anti-EGFR mAb ICR62 is accompanied by an increased level of cell surface EGFR, and upregulation of phosphorylated HER-2 and HER-3 proteins., Authors show experimental evidence for an ErbB3 gain-of-function point mutation located in the C-lobe asymmetric dimerization interface, which shows enhanced phosphorylation at low ligand dose associated with increased kinase activity., critical pathophysiologic event in the evolution of HER2-amplified cancers is the loss of the input signals that normally drive TORC2 signaling, repositioning it under Akt dependency, and fundamentally altering the role of HER3, Study shows that ERBB3 is a novel regulator of beta-cell apoptosis and found rs2292239 strongly correlated with residual b-cell function and metabolic control in children with type 1 diabetes., findings newly identify a physiological function of the NRG1-ErbB2-ErbB3 axis in trophoblast survival during human placental development., BRCA1-associated DCIS did not express ER, PR or HER2, while most BRCA2-associated DCIS did express ER and PR. BRCA1- as well as BRCA2-associated DCIS had expression of HER3 and C-MET, our results suggest that HER3 over-expression may be associated with worse overall survival in gastric cancers, Data suggest that NDRG1 down-regulates expression and activation of HER1/EGFR, HER2/ERBB2, and HER3/ERBB3 in response to epidermal growth factor (EGF) ligand in pancreatic/colonic neoplasm cells., NRG1 promotes the proliferation and migration of coronary artery smooth muscle cells by enhancing the phosphorylation of ErbB2, ErbB3 and ErbB4., HER2/HER3 interaction and increased expression was linked to risk for poor outcome in lung cancer patients., ErbB3 nuclear translocation is a common event in proliferating tissues., High EGFR expression was an independent risk factor for shorter overall survival (OS), whereas high HER3 expression was associated with a borderline significant trend towards a longer OS., while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 and ErbB4 expression., HPV 16 E2 can modulate ErbB-3 by interacting with Nrdp-1, which is involved in the regulation of this receptor, via ubiquitination and degradation., Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1., measurements comprising the receptors EGFR, ERBB3 (HER3), and the cyclin-dependent kinase inhibitor p27 (CDKN1B) was found to accurately predict dependence on PI3K/AKT vs. MAPK/ERK signaling axes in HER2+ cancers, HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study, Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma,
OFFICIAL_GENE_SYMBOL ERBB3,
OMIM_DISEASE Lethal congenital contractural syndrome 2,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology., disease:Overexpressed in a subset of human mammary tumors., domain:The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins., function:Binds and is activated by neuregulins and NTAK., PTM:Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily., similarity:Contains 1 protein kinase domain., subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4 and MUC1., tissue specificity:Epithelial tissues and brain.,
erb-b2 receptor tyrosine kinase 4(ERBB4) erb-b2 receptor tyrosine kinase 4(ERBB4) Related Genes Homo sapiens
CHROMOSOME 2,
CYTOBAND 2q33.3-q34,
ENSEMBL_GENE_ID ENSG00000178568,
GENERIF_SUMMARY cleavage by gamma-secretase releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus, ErbB4 expression was observed through all stages of chondrocytic differentiation in vitro., deletion of the PDZ domain recognition motif does abrogate the gamma-secretase cleavage of ErbB-4, ErbB4 is specifically associated with neuritic plaques in the hippocampus of Alzheimer disease patients., ErbB4 signaling is growth inhibitory and may be coupled to tumor suppression in prostate cells, Expression of HER4 protein correlates with favourable tumor stage in pancreatic cancer patients., YAP is a potential signaling partner of the full-length ErbB4 receptor at the membrane and of the COOH-terminal fragment of ErbB-4 that translocates to the nucleus to regulate transcription, ErbB-4 characterization of the cleavage site and m80 fragment, Nuclear localization of the activated p80 fragment of Her-4 is associated with osteosarcoma pathogenesis, HER4 is involved in a non-proliferative or even protective role in breast cancer., betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas., nuclear localization of STAT5A and stimulation of the beta-casein promoter requires nuclear translocation of the ERBB4 intracellular domain 4ICD; binding of the two proteins at transcription factor target promoters results in activation of gene expression, ErbB4 is increased by cAMP, a potent inducer of decidualization of the endometrial stroma., erbB receptor inactivation by unknown mechanisms results in altered splicing of bcl-x towards enhanced formation of proapoptotic Bcl-xS, thereby contributing to enhanced apoptotic susceptibility of failing human myocardium, Association of ErbB4 expression with clinical outcome is dependent on the subcellular localization of ErbB4 and that a proteinase-cleavable ErbB4 isoform promotes growth of ER-positive breast cancer and enhances ER-mediated gene transcription., proteolytic processing of ERBB4 is a critical event regulating multiple receptor signaling activities, Absence of HER4 expression is associated with recurrence of ductal carcinoma in situ of the breast, HB-EGF may play a vital role in regulating luteal growth in a juxtacrine manner and through activating HER4 signalling, Data show that expression of the ErbB-4 ICD fragment leads to its constitutive association with and tyrosine phosphorylation of Mdm2., WWOX antagonizes the function of YAP by competing for interaction with ErbB-4 and other targets and thus affect its transcriptional activity., the s80 domain of ErbB-4 may function to phosphorylate substrates in the cytoplasm or nucleus, Data suggested that alterations of ERBB4-mediated signaling pathway by ERBB4 mutations may contribute to the development of human cancers., Results report the 2.4 A crystal structure of the extracellular region of human ErbB4 in the absence of ligand and show that it adopts a tethered conformation similar to inactive forms of ErbB1 and ErbB3., Mutation screening of erbB4 in 14 schizophrenics revealed 15 SNPs., novel transforming mechanism for the ErbB4 receptor in human breast cancer that is 1) specific for a single receptor isoform and 2) depends on proteinase cleavage and kinase activity but not ligand activation of the receptor, Results showed a highly significant difference between patient and control groups in three SNPs from one linkage disequilibrium block both in allele and genotype frequencies, as well as a risk haplotype., Activation of Rac by heregulin beta1 is mediated not only by ErbB3 and ErbB2 but also by transactivation of EGFR, and it is independent of ErbB4., A monoclonal antibody to ErbB-4 showed both an inhibitory effect on growth rate and an increasing apoptotic rate in the cells expressing ErbB-4., ErbB4 receptor expression was accompanied with positive regulation of PP2A for phosphorylation of Shc Tyr317 and its downstream ERK phosphorylation in MCF-7 and SK-OV-3 cell lines, but not in LNCaP and PC-3 cells., These experiments demonstrate a novel mechanism controlling ErbB receptor activation. Ras induces ErbB4 receptor phosphorylation in a non-autocrine manner and this activation depends on multiple Ras effector pathways and on ErbB4 kinase activity., Function of HER4 and its fragments is particularly important, with the different functions of nuclear and mitochondrial HER4 in breast cancer., HER3 and HER4 has been related to a favourable prognosis in bladder cancer., ErbB4 has 5 docking sites for Grb2. It is a direct binding partner for STAT5. It functions as control center & integration site for signaling processes, involving stimulation with neuregulin., Neurogulin 1 induced activation of erbB4 in the prefrontal cortex in schizophrenia., Cytosolic but not membrane ERBB4/4ICD expression in primary human breast tumors was associated with tumor apoptosis, providing a mechanistic explanation for the loss of ERBB4 expression during tumor progression., -16 E5 protein can form a complex with ErbB4 via binding to the extracellular and transmembrane domains of ErbB4 (JM-b/CYT-1), Down regulation of ERBB4 is associated with brease, prostate and ovarian cancer, Expression of c-erbB-4 in brain medulloblastoma and its correlation with prognosis., low-level hedgehog signalling in human medulloblastoma is associated with the selective maintenance of high ErbB-4 CYT-1 expression, an alteration that exerts tumor-promoting effects, Contribution of an autocrine ERBB4/estrogen receptor signaling pathway to tumor growth and therapeutic response should be considered when managing patients with ER-positive breast cancer., These results suggest that heregulin-mediated growth inhibition in HER4-postive breast cancer cells requires BRCA1., phosphorylation of ErbB4 tyrosine 1056 is critical for coupling ErbB4 to prostate tumor suppression, Data show that upon neuregulin-induced activation and presenilin-dependent cleavage of ErbB4, the receptor's intracellular domain forms a complex with TAB2 and the corepressor N-CoR., Dysregulation of splice-variant specific expression of ErbB4 in the brain underlies the genetic association of the gene with schizophrenia., Inhibits mammary cell proliferation through the action of its cytoplasmic domain., cycle-dependent degradation of s80(HER4) limits its growth-inhibitory action, and stabilization of s80(HER4) enhances tumor suppression, thus providing a link between HER4-mediated growth inhibition and cell cycle control, study concludes that erbB4 mutations are rare in Japanese people with lung cancer, ErbB4 isoform that is proteinase cleavable but does not contain a PI3K-binding domain in its cytoplasmic tail, mediates important functions in renal epithelial cells in response to HB-EGF, Expression of Wwox is associated with ErbB4 expression and that their coexpression has prognostic significance in breast cancer., Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence., ErbB3 and ErbB4 genes play different roles in carcinogenesis and development, and relate to the reccurrence of carcinoma., The ERBB4 -782 G>T polymorphism, by virtue of its in vitro functional implication and incidence, is a risk factor for breast and colorectal cancer., HER4 amplification showed a positive trend in overall and disease-free survival., All ErbB4 residues contacted by lapatinib are conserved in the EGF receptor and HER2/ErbB2, which lapatinib also targets., Ras activation dynamics is dominated by heterodimer-mediated signaling coordination with a large initial speed of dimerization when the concentration of the ErbB4 receptor is considerably high, Her 4 expression showed significantly decreased expression in differentiated throid cancer and correlated with lower T stage, The restriction of robust SVZ ErbB4 expression to neonate and infant age groups may indicate that SVZ-derived ErbB4-dependent postnatal neuronal development is most extensive within a narrow time frame early after birth., our results suggest that variations of the ErbB4 genotype may confer risk for schizophrenia illness via its impact on left frontotemporal connectivity in human brain., several previously unrecognized interactions led to the finding that ErbB4 can recruit and activate STAT1; at a systems level, ErbB4 is much more selective than the other ErbB receptors, ErbB4 expression and signaling are key elements for TNF responses in vivo and in cell culture, protecting intestinal epithelial cells from apoptosis in the inflammatory environment., HER3 and HER4 gene transcription is associated with better prognosis in high-risk early breast cancer, results suggest that ErbB4 processing and function may be altered in brain tumours, such as medulloblastoma and pilocytic astrocytoma, via differential expression of juxtamembrane transcript variants., selective loss-of-function mutations of ErbB4 failed to phosphorylate STAT5 and suppressed differentiation of mammary carcinoma., The biological function and clinical implications of HRG, HER-3 and HER-4 in breast cancers negative/low expression of HER-2 remain unclear, Removal of cell surface heparan sulfate increased TACE activity and cleavage of ErbB4 receptor., Poor downregulation of ErbB4 receptors is not due to sequence variations in the Proto-Oncogene Proteins Cbl binding site of these receptors., expression of ErbB3 and ErbB4 may identify a colorectal cancer subgroup with stage II and III colorectal cancer at higher risk of recurrence, estrogen receptor splice variant and ErbB4 may have roles in gene susceptibility pathways in schizophrenia, Results showed that 45.8% of typical carcinoid and 28.6% of atypical carcinoid tumors express EGFR, 100% of the tumors lack expression of ErbB2, and 100% have moderate to intense staining for ErbB3 and ErbB4., Current data relating to the prognostic significance of HER3 and 4 receptors, as well as their impact on the activity of HER-targeting therapies in patients with breast cancer., WWP1 and its family members suppress the ErbB4 expression and function in breast cancer, The Cyt1 and Cyt2 ErbB4 isoforms, differing by only 16 amino acids, exhibit markedly opposing effects on mammary epithelium growth and differentiation., Data show that aberrant expression of ErbB2, ErbB3 and ErbB4 in the two resistant cell lines, suggesting the existence of an autocrine loop leading to constitutive activation of MAPK and PI3K/Akt survival pathways., Both HER4 expression and HER4 gene amplification emerged as independent prognostic markers in Herceptin-treated breast cancer patients and responsiveness to Herceptin turned out to be more efficient if tumour cells show HER4 expression., Melanoma cells expressing mutant ERBB4 had reduced cell growth after shRNA-mediated knockdown of ERBB4, Results suggest that the HER4 intracellular cytosolic domain 4ICD has important pathological functions and may be used to identify node-negative breast cancer patients at low risk of relapse and an improved survival., Data demonstrate that sequence differences on the C-lobe surface influence the heterodimerization and activation of ErbB2/4 kinase domains., EGFR, HER-2 and HER-4 expression is not associated with poorer survival in neuroendocrine cancer, Data suggest that pulmonary ErbB4 deletion results in a structural and functional delay in fetal lung development, indicating a crucial regulatory role of ErbB4 in the timely progression of fetal lung development., The HER4 intracellular domain is a physiologically important ERalpha coactivator and cooperates with ERalpha to potentiate PgR expression in the normal and malignant breast., chronic overexpression of ErbB4 in the context of inflammation could contribute to colitis-associated tumorigenesis by inhibiting colonocyte apoptosis, The result of this study supported the involvement of the ERBB4 gene in schizophrenia in Han Chinese in Taiwan.., verified HER4 promoter methylation in primary breast carcinomas and detected a significant increase in HER4 promoter methylation in HER4-negative breast tumors, Novel splice variants of ErbB4 exist in the developing and adult human brain., We observed epistasis between NRG1 (rs10503929; Thr286/289/294Met) and its receptor ERBB4 (rs1026882; likelihood ratio test P = .035); a 3-way interaction with these 2 SNPs and AKT1 (rs2494734) was also observed., ERBB4 mutations and expression was not associated with lung cancer., HER receptor family plays an important role in embryonic development and in pathogenesis and progression of neuroblastic tumors., Data show that interactions between beta1 integrin and ErbB4 occur in a spatiotemporally-regulated manner, and such interaction contributes to the integrin-dependent cell migration., this study found that genetic variation at the rs4673628 locus in the ErbB4 gene was significantly associated with anterior limb of the internal capsule white matter. integrity which was also significantly and positively associated with mnemonic function, data indicate that somatic point mutation of ERBB4 gene is rare in common solid cancers except malignant melanoma; also, they suggest that ERBB4 mutation may play roles in limited types of human cancers, Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects., 148 Penile squamous cell carcinoma were microarrayed and immunostained for phosphorylated EGFR (pEGFR), HER2, HER3, HER4, phosphorylated Akt (pAkt), Akt1 and PTEN proteins., the kinase-domain makes a significant contribution to the overall dimerization affinity of the full-length Her4 protein, Letter, A modestly associated novel variant that could affect alternative splicing of ERBB4, was found.., data provide evidence for conserved expression patterns of ErbB4 across different rodent and primate species, both at the cellular and subcellular level., The HER4 is expressed in lymphoma cells, especially in MALT and FL cells of the gastrointestinal tract., ErbB4 rs7598440 genotype significantly predicts cortical GABA concentration, with (A) adenosine allele carriers having higher GABA as predicted by allelic impact on ErbB4 expression., No significant association between ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia is found in the Han Chinese population., Report here the 2.5 A crystal structure of the N-terminal three extracellular domains of ErbB4, which bind ligand but lack domain IV and thus the tether contact., Verbal working memory performance was associated with 2 variants of ERBB4. No associations were detected between ERBB4 variants and trait schizotypy. rs7598440 was associated with psychotic experiences expressed under stressful environmental conditions., Data suggest that the rs6147150 polymorphism of ErbB4 may be associated with hepatocellular carcinoma (HCC) risk, in part through let-7c-mediated regulation, and may be involved in the pathogenesis of HCC in Chinese populations., soluble ErbB4 intracellular domain promotes HIF-1alpha stability and signaling via a novel mechanism., Immunoreactivity for erbB1 was strong and that for erbB2 and 3 was moderate, while that for erbB4 was faint in nasal mucosa chronic rhinitis., ErbB4 mutant mice exhibit hyperactivity in a novel environment and deficits in prepulse inhibition of the startle response., current results indicated that HER4 protects NBL cells from multiple exogenous apoptotic stimuli, including anoikis, nutrient deficiency, and cytotoxic chemotherapy., A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34 in Korean women., Transgenic mouse embryos lacking ErbB4 display deficits in early oligodendrocyte precursor cell migration away from different oligodendrogliogenic regions., The A-allele of rs7598440 in ERBB4 is associated with increased gamma-aminobutyric acid (GABA) concentrations in the central nervous system., This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma., PIAS3 is a novel regulator of ErbB4 receptor tyrosine kinase, controlling its nuclear sequestration and function., amplification of ERBB4, C-MET and CD44 was significantly associated with certain clinicopathological characteristics, particularly tumor differentiation and cancer-related death and poor survival., Although statistically not significant, the tendency towards associations between ERBB4 polymorphisms and the risk of schizophrenia and SPEM abnormality in this study from a Korean population would be helpful for further genetic studies in schizophrenia., We report cell-based assays that provide evidence for active, singly ligated dimers of human EGFR and its homolog, ErbB4/HER4., This effect was blocked by the inhibition of ErbB4, a key NRG1 receptor., ErbB4 processing is enhanced in breast cancer tissue in vivo, HER4 expression was not associated with prognostic factors in ER-positive breast cancer., We observed the reaction kinetics between fluorescently labeled single HRG molecules and ErbB3/B4 on the surfaces of MCF-7 human breast cancer cells., Low ErbB4 expression is associated with metastasis in breast cancer., Rate of ErbB4 expression in remaining nigral dopaminergic neurons increases in Parkinson disease., Results suggest a possible participation of erbB1-4 and claudin-1 in tissue remodelling in chronic hypertrophic rhinitis., Thus, our findings reveal c-Src-mediated inhibitory regulation of ErbB4 nuclear signaling upon EGFR activation., The study indicates that hotspot mutations in the ERBB4 gene are rare in Chinese patients with melanomas., identified a novel 6-kb haplotype block in ERBB4 which was significantly associated with risk of developing schizophrenia Caucasians, total ErbB4 protein expression was not significantly associated with prognostic markers, The present data suggest that ErbB2, ErbB3, and ErbB4 genes may have a role in bladder cancer tumorigenesis., There is no enrichment of ERBB4 mutations BRAF/INRAS mutant melanoma cells., Data suggest that ErbB receptors (ERBB2, ERBB3, and ERBB4) are expressed in most endometrial cancers; expression of ErbB receptors appears to be related to poor prognosis; dismal outcomes correlate with cancers positive for all three ErbB receptors., No cross-reactivity of 4B5 with membrane-bound HER4 was identified in the clinical IHC analysis of formalin-fixed paraffin-embedded breast carcinoma cases as evidenced by the HER4 antibody clone E200., The association of SNP loci derived from GWAS in European type 1 diabetes with diabetic nephropathy was not replicated in the Japanese patients with type 2 diabetes, although the ERBB4 locus may have some effect also in Japanese type 2 diabetes., ERBB4 expression is elevated in metastatic tumour samples and correlates with disease progression in Ewing sarcoma., Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability., Data provide evidence for the involvement of intron 1 EGFR variants and intron 24 ERBB4 variants in modulating risk for the development of in situ and invasive cervical cancer., In tumours from postmenopausal women harbouring normal HER2 gene copy numbers, we found HER2 and HER4, but HER3 levels in particular, to be elevated compared to normal tissues, these data suggest that Nrg3/ErbB4 signaling may be an important factor in nicotine dependence., Expression of HER4 JM-a/CYT2 isoform relate to survival of bladder cancer patients only if the tumors do not express ESR1., our study reveals a positive impact of Her4 (JM-a) expression in triple-negative (OS) and Her2/ER-positive (EFS) breast cancer., reduced autophosphorylation of ErbB4 upon NRG-1 stimulation is involved in the pathogenesis of amyotrophic lateral sclerosis, Data suggest that WW2 domain of WWOX (WW domain containing oxidoreductase protein) augments binding of WW1 domain of WWOX to PPXY motifs within intracellular domain of ErbB4, implying that WW2 serves as chaperone within WW1-WW2 tandem module of WWOX., Studied molecular and network models of HER4/ErbB4 activation and signaling in order to elucidate molecular mechanisms of activation and rationalize the effects of the clinically identified HER4 somatic mutants., In summary, we demonstrate for the first time that a cell surface receptor functions as an obligate ER coactivator with functional specificity associated with breast tumor cell proliferation and cell cycle progression., these results support a cooperation of ErbB1, ErbB4, and members of the MMP family in predicting OSCC invasion and poor clinical outcomes., Results further emphasize the role of HER4 as an important oncogene in malignant melanoma., MiR-302b is a potential molecular marker of esophageal squamous cell carcinoma and functions as a tumor suppressor by post-transcriptionally regulating ErbB4., discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer, This study provide evidence from this independent Australian postmortem cohort that ErbB4-JMa expression is elevated in schizophrenia., The diverse biologic activities of ERBB4 isoforms., Study addresses whether the ERBB3 mutations altering Val-104 were present in homologous amino acids of ERBB family genes EGFR, ERBB2 and ERBB4 in CRC., Elevated ERBB4 expression is associated with drug resistance in colorectal cancer., ErbB3, ErbB4, and MET showed marked expression in 76%, 98%, and 96% of ovarian carcinoma cases., Data shows that HER4 expression status allows stratification of Cholangiocarcinoma patients into different survival categories., In 238 primary invasive breast cancer patients, authors analyzed the expression levels of HER4 extracellular (JM-a and JM-b) and intracellular (CYT-1 and CYT-2) domains, germ-line ERBB4 variant -815A>T as a novel prognostic marker in high-risk early breast cancer, An exon array analysis of 155 breast tumors revealed that the relative mRNA abundance of the ErbB4 CYT2 variant was increased in ER+ HER2- breast cancer patients, A small cluster located in the 5' end of the ERBB4 gene showed a nominal association mainly with negative, general and total dimensions of the Positive and Negative Syndrome Scale., NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC., Our data suggested that individuals in Chinese population with the ErbB4 12-bp deletion allele may be at higher risk for CRC, rs6147150 would potentially be a promising novel biomarker for Colorectal cancer susceptibility, Taken together, our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation., Phosphorylated ErbB1-4 and heregulin contribute to poorer patient prognosis in CRC. This heregulin-ErbB family member autocrine loop may be a candidate for targeted treatment of CRC., analysis of activator-receiver preferences among ErbB proteins, identifying neuregulin 1 and its cognate receptor ERBB4 [epidermal growth factor receptor (EGFR) family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4] as a major receptor complex that activates YAP activity, These observations connect the unusual nuclear function of a growth factor receptor with a mechanosensory pathway and suggest that NRG1-ERBB4-YAP signaling contributes to the aggressive behavior of tumor cells., There are isoform-specific roles of ERBB4 during puberty and early pregnancy. CYT-1 ERBB4a has oncogenic properties., Report high expression of HER2 in gastric adenocarcinomas., EGFR/ERBB4 expression in trophoblasts correlates with cell cycle progression and hyperplasia in complete hydatidiform moles, Authors investigated the effects of ERBB4 variants and family history of SCZ and/or BPD (FH) on cortical measures and cognitive performances., ERBB4 is over-expressed in human colon cancer and enhances cellular transformation., The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer., the presence of activating driver mutations of ERBB4 in non-small cell lung cancer, nuclear HER4 seem to be co-located with estrogen receptors, however, we did not find support for overall HER4 expression in independently predicting response of tamoxifen treatment in breast cancer, Dysregulated ErbB4splicing in schizophreniamay contribute to lower activity of parvalbumin interneurons and an activity-dependent down-regulation of parvalbumin expression., A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling., Identification of a new subclass of ALK-negative Anaplastic large-cell lymphoma characterized by aberrant expression of ERBB4-truncated transcripts carrying intronic 5' untranslated regions., The connections of EGFR and ERBB4 signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB-regulated developmental processes and may contribute to metabolic remodeling in ERBB-driven cancers., NRG1 promotes the proliferation and migration of coronary artery smooth muscle cells by enhancing the phosphorylation of ErbB2, ErbB3 and ErbB4., In this study, we developed an anti-ErbB4 mAb (clone P6-1) that suppresses NRG-dependent activation of ErbB4 and examined its effect on breast cancer cell proliferation in the extracellular matrix., while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 and ErbB4 expression., HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study,
OFFICIAL_GENE_SYMBOL ERBB4,
OMIM_DISEASE Amyotrophic lateral sclerosis 19,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., domain:The WW-binding motifs mediate interaction with WWOX., function:Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin., PTM:Isoform JM-A is processed but not isoform JM-B. So, they respectively represent cleavable and non-cleavable forms of the receptor., PTM:Ligand-binding increases phosphorylation on tyrosine residues., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily., similarity:Contains 1 protein kinase domain., subunit:Homodimer or heterodimer with each of the other ERBB receptors (Potential). Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with CBFA2T3, MUC1 and WWOX., tissue specificity:Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A and isoform JM-B are expressed in cerebellum, but only the isoform JM-B is expressed in the heart.,