Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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eukaryotic translation initiation factor 4B(EIF4B) eukaryotic translation initiation factor 4B(EIF4B) Related Genes Homo sapiens
CHROMOSOME 12, X,
CYTOBAND 12q13.13, Xq23,
ENSEMBL_GENE_ID ENSG00000063046,
GENERIF_SUMMARY The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding., eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation, data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES, Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3., The interaction of eIF4AI with two accessory factors, eIF4B and eIF4H, was studied., Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation., Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR., Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B., ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication., our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes, Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis., Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain., eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL, eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells., The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus., EIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy., S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region., MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.,
OFFICIAL_GENE_SYMBOL EIF4B,
SP_COMMENT function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F., similarity:Contains 1 RRM (RNA recognition motif) domain., subunit:Self-associates and interacts with EIF3 p170 subunit.,