Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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epidermal growth factor receptor(EGFR) epidermal growth factor receptor(EGFR) Related Genes Homo sapiens
GENERIF_SUMMARY A truncated form of the hEGFR ectodomain comprising residues 1-501, unlike the full-length hEGFR ectodomain (residues 1-621), binds hEGF and hTGF-alpha with high affinity and is a competitive inhibitor of EGF-stimulated mitogenesis., Chemical/biological model for EGFR activation., EGFR has been detected in the nucleus and might function as a transcription factor to activate gene transcription., The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR)., effects of receptor-selective retinoid ligands on EGFR-associated signal transduction, Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides, this study, 11 analogs of a fragment of the B-loop of EGF-related peptides from several species were synthesized to study binding to A431 human epidermoid carcinoma using both 125I-EGF and [3'4'-3H-Tyr(22,29), Abu(20,31)]EGF(20-31)-NH(2)., CsA affects EGF-r metabolism in gingival keratinocytes resulting in an increased number of cell surface receptors, Calmodulin binds to the EGFR, data demonstrate that prostaglandin E2 transactivates EGFR and triggers mitogenic signaling in gastric epithelial and colon cancer cells as well as in rat gastric mucosa in vivo, sequestration in non-caveolar lipid rafts inhibits lipid binding, Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors, estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology, Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase, contig map for the EGFR region and markers positioned on its associated physical map to the analysis of 7p11.2 amplifications in a series of glioblastomas., EGFR is often strongly expressed and is a potential therapeutic target in patients with malignant thymic tumors, Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length., epidermal growth factor receptor activity on fertilization capacity of testicular harvested spermatozoa, results suggest a potential mechanism by which maintenance of low levels of EGFR expression and subsequent EGFR upregulation may be attributed to the loss of transcriptional repression of EGFR gene expression in hormone-dependent breast cancer cells, Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and zinc-induced Ras activation, Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines., blocking of ubiquitination by inhibiting Src family kinases, novel mechanism of EGFR internalization that does not require ligand binding, receptor kinase activity, or ubiquitylation and does not direct the receptor into a degradative pathway, Dephosphorylation of the EGFR and the consequent suppression of EGFR signalling. Review., second cysteine-rich region contains targeting information for caveolae/rafts, Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF, determination of decorin binding site, Expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors, Detection of serum epidermal growth factor receptor in the diagnosis of proliferation of pituitary adenomas, These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling., These results indicate that epidermal growth factor (EGF) receptors can form a ligand-independent inactive dimer and that receptor dimerization and activation are mechanistically distinct and separable events., ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation; cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK., Rac activation upon cell-cell contact formation is dependent on signaling from here, Differential EGFR patterns by interphase cytogenetics in malignant peripheral nerve sheath tumor and morphologically similar spindle cell neoplasms., Results show that the juxtamembrane region of the epidermal growth factor receptor is necessary for accurate polarized expression of the native molecule., The results of this study indicate that dual inhibition of focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) signaling pathways can cooperatively enhance apoptosis in breast cancers., Stimulation of cells with EGF rapidly leads to phosphorylation of Hrs, raising the question whether the EGF receptor tyrosine kinase phosphorylates Hrs directly. Several downstream kinases, rather than the active receptor kinase are responsible., These results demonstrate that 1,25(OH)(2)D(3) alters EGFR membrane trafficking and down-regulates EGFR growth signaling., EGF receptor expression was elevated in the prefrontal cortex in schizophrenic, Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors., findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma, Data show that human sprouty2 potentiates epidermal growth factor receptor signalling by specifically intercepting c-Cbl-mediated effects on receptor down-regulation., Data indicate that phospholipase A2 downregulates the EGF receptor-mediated intracellular signal transduction that may be mediated by arachidonic acid and/or ceramide., Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha., Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains, caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation., determination of whether G protein-coupled receptor kinase-2 can phosphorylate and desensitize epidermal growth factor receptor, Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors, ligand-independent activation of the epidermal growth factor receptor is triggered by cholesterol depletion from the plasma membrane, Endocytosis is regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre., Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma., epidermal growth factor receptor may have a role in disease relapse and progression to androgen-independence in human prostate cancer, mediation of synergism with c-src by STAT5b, mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo, hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway., EGF receptor is activated in a pathway that requires ARF4 to induce phospholipase D2, Mutual interaction of EGFR with c-Src is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review., EGFR, DI, and the diploid are valuable targets for judging metastasis and recurrence of gastric cancer before and after operation., Expression of the invasive phenotype in breast epithelial cells requires increased EGF receptor signaling, involving both PI 3-kinase and Erk 1,2 activities, which leads to enhanced secretion of MMP-9 and transcription of invasion-related genes., Levels of this receptor are lowered in cryptorchism., targeting in cancer, involved in apoptosis (REVIEW), activation regulates mutation and epidermal growth factor receptor activation regulates vascular endothelial growth factor mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter., TPA-induced AP-1 activation requires EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation., SKMG-3 cells produced high levels of EGFR protein. Signals from overexpressed EGFRs contribute to the constitutive phosphorylation of Erk, but these signals may not be required for the constitutive activation of PI3K or AKT1., role in mediating thromboxane A2-dependent -signal-regulated kinase activation, the mechanism of attenuated ERK signaling in EGFR-overexpressing cells is a sequestration of ERKs at the cell membrane in EGFR-containing complexes., Review. Mucin transcription in response to both gram-positive bacteria and tobacco smoke is mediated through activation of the epidermal growth factor receptor (EGFR)., Expression of EGFR seems to play an important role in metastasis, especially liver metastasis and recurrence of pancreatic cancer., in glioblastoma multiforme patients a complex relationship exists between epidermal growth factor receptor expression and age, results demonstrate that tamoxifen resistant MCF-7 cell growth is mediated by the autocrine release and action of an epidermal growth factor receptor-specific ligand inducing preferential epidermal growth factor receptor/c-erbB2 dimerization, Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis., EGFR binds to c-src and has a role in oncogenesis, Exogenous OPN increased EGFR mRNA expression, as well as EGFR kinase activity. Inhibition of EGFR significantly impaired the cell migration response to OPN., Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region., Five autophosphorylation sites in the extra-kinase C-terminal domain of EGFR are not required for the ability of EGFR to induce morphological differentiation of PC12 cells., data indicate that growth hormone, by activating extracellular signal related kinases, can modulate epidermal growth factor-induced epidermal growth factor receptor trafficking and signaling, Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 & ERCC1 in DU145 & LNCaP prostate carcinoma through MAPK signaling indicating a capacity of the EGFR-ERK signaling to modulate DNA repair in cancer cells., EGFR microsatellite polymorphism is associated with autosomal dominant polycystic kidney disease., Expression of EGF and EGFR is involved in the gallbladder carcinogenesis, and is related to high activity of cell proliferation., propose a role of Ent-1 in the trafficking of EGFR to down-regulate intestinal mitogenic signals, highlighting the mechanisms of cell growth arrest associated with enterocytic differentiation, Human colon carcinoma cells that overexpress cyclooxygenase exhibit growth stimulation and induction of this protein., Overexpression of an introduced EGFR, under an E1A-insensitive heterologous promoter, blocked E1A induction of apoptosis in SCC cells. E1A-mediated EGFR downregulation appears to be the cause not consequence of E1A-induced apoptosis in these cells., Data show that by using RNA interference , the expression of endogenous erbB1 can be specifically and extensively suppressed in A431 human epidermoid carcinoma cells., The study found that over-expression of EGFR occurred more often in cases of cervical cancer (50%) compared to breast cancer cases (36%), while in breast cancer EGFR expression correlated significantly with metastasis of the lymph nodes., EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization, Nitric oxide and nitric oxide donors induce EGF receptor phosphorylations, in A431 tumor cells., deltaEGFR may contribute to glioblastoma development, EGFRvIII expressed in human tumors is phosphorylated and hence activated; sustained activation of EGFRvIII is implicated in the pathogenesis of non-small cell lung cancers, ZO-1 bound to EGFR irrespective of the phosphorylation status of EGFR. EGFR associated ZO-1 was highly tyrosine-phosphorylated only in primary colorectal cancers but was dephosphorylated in the liver-metastasized cancers., The expression of this protein was not different in the clone cell variants or the A431 parental line., Results suggest that epidermal growth factor receptor and protein kinase C activation are involved in 12- O-tetradecanoylphorbol-13-acetate-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells., signaling intensity determines intracellular protein interactions, ubiquitination, and internalization, Loss of PTEN/MMAC1/TEP in tumor cells expression this protein counteracts the antitumor action of EGFR tyrosine kinase inhibitors., carboxyl-terminal mutation of the epidermal growth factor receptor alters tyrosine kinase activity and substrate specificity, androgens promote an increase in the activity of the epidermal growth factor (EGF)-network by increasing ErbB1 levels, and this activity of is essential for androgen-induced proliferation and survival of the prostate cancer LNCaP cell line., findings establish Cbl protein as the major endogenous ubiquitin ligase responsible for epidermal growth factor receptor degradation, EGFR gene expression is identified in recurrent glioblastoma multiforme, Seasonal allergic rhinitis subject showed significant elevation in EGFR expression, consistent with the observation of mucus hypersecretion in allergic rhinitis., Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system., HEGFR was expressed in the subventricular zone embryologically, Epidermal growth factor receptor negatively regulates intracellular kinase activation in the absence of ligand, Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta., Data show that stimulation of epidermal growth factor receptors differentially regulates chemokine expression in keratinocytes., PGE2 regulates cell migration via the EGFR, and affects cell division and neoplasm invasiveneess., Data support that EGFR and HER-2/neu play an important role in cell cycle control in ductal carcinoma in situ., The results suggest that activation and nuclear localization of EGFR may be needed for induction of NOS-2 in response to elevated intraocular pressure in glaucomatous optic neuropathy., Ligand-induced EGFR degradation is preceded by proteasome-dependent EGFR de-ubiquitination., Bcl-2 and Bax, being nuclear matrix associated proteins, are probably involved in the EGFR-cDNA induced malignant conversion of glioblastoma cells by introducing EGFR cDNA into the tumor cells., Data show that detachment-induced expression of Bim requires a lack of beta(1)-integrin engagement, downregulation of EGF receptor (EGFR) expression and inhibition of Erk signalling., PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor., EGFR is a necessary component for HCMV-triggered signalling and viral entry, endosomal epidermal growth factor receptor stimulates cell growth, EGFR has a role in beta2 tyrosine phosphorylation of AP-2 by interacting at receptor 974YRAL and di-leucine motifs, Results demonstrate that mice humanised for epidermal growth factor receptor (EGFR) display tissue-specific hypomorphic phenotypes and describe a novel function for EGFR in bone development., EGF receptor down-regulation by UVA may play an important role in the execution of the cell suicide program by attenuating its anti-apoptotic function, EGFR is an aldosterone-induced protein and is involved in the manifold (patho)biological actions of aldosterone, EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis., identification of ligand-induced site-specific phosphorylation of epidermal growth factor receptor, depending on their localization, oxytocin receptors transactivate EGFR and activate ERK1/2 using different signalling intermediates. The final outcome is a different temporal pattern of EGFR and ERK1/2 phosphorylation, These results indicate that the EGFR signaling pathway is involved in urothelial regeneration., Mitogenic effects of gastrin-releasing peptide in head and neck squamous cells are mediated by activation of EGFR., ERBB1 is overexpressed and may play a role in high-grade diffusely infiltrative pediatric brain stem glioma, Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of putative YXX Phi and dileucine (LL) transport motifs within Ad2 10.4-14.5 for down-regulation of Fas, TRAIL-R1, TRAIL-R2, and EGFR., Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas., ganglioside GM3 inhibits integrin-induced, ligand-independent epidermal growth factor receptor phosphorylation (cross-talk) through suppression of Src family kinase and phosphatidylinositol 3-kinase signaling, Up-regulation of EGFR is associated with renal cell carcinoma, cholesterol depletion with cyclodextrin induced an increase in both basal and EGF-stimulated EGF receptor phosphorylation, at specific tyrosine sites, that was associated with an increase in the intrinsic kinase activity of the EGF receptor kinase., the EGF receptor is abundantly expressed in epithelioid vascular smooth muscle cells and the activation of this receptor results in cell cycle arrest through activation of the mitogen-activated protein kinase pathway, lysosomal degradation by adenovirus E3 RIDalpha protein dependent on specific domains, findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors, heregulin/EGFR system as a possible important physiologic growth regulatory system in melanocytes in which multiple deregulations may occur during progression toward melanoma, all resulting in, or indicating, growth factor independence., demonstration that metalloproteinase-mediated transactivation of the EGFR is a key mechanism of the cellular signalling network that promotes MAPK activation as well as tumour cell migration and invasion, transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses, data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor, E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes., The Id-1-induced androgen-independent prostate cancer cell growth was correlated with up-regulation of EGF-R., results support a structural model for oligomerization of EGF receptors in which dimers are positioned head-to-head with respect to the ligand-binding site, SHP-2/Gab1 association is critical for linking EGFR to NF-kappaB transcriptional activity via the PI3-kinase/Akt signaling axis in glioblastoma cells, sorting of endocytosed epidermal growth factor receptor into the degradation pathway requires both its kinase activity and actin-binding domain, involvement urokinase plasminogen activator secretion and cell motility in breast cancer cells, EGFR and ErbB-2 have roles in ligand-dependent apoptosis that could be a natural mechanism to protect tissues from unrestricted proliferation, the adhesion-dependent activation of EGF receptor signaling is promoted by L1-type CAMs in vitro and in vivo, the relationship between the egfr polymorphism and breast cancer risk, Overexpression of EGFR is associated with recurrent non-small cell lung cancer, PGF(2 alpha)-FP receptor may promote endometrial tumorigenesis via phospholipase C-mediated phosphorylation of EGF receptor and MAPK signaling pathways., CaM co-immunoprecipitates with EGF-activated and non-activated receptors, EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2, A significantly higher frequency of EGFR expression occurred in PC than in AC glottic cancer., EGFR and COX-2 cooperate to promote cervical neoplasm progression, a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF, Sustained hyaluronan depolymerization is expected to cause tissue kallikrein activation, EGF release, and EGFR signaling., Trypsin exerts robust trophic action on colon cancer cells and underline the critical role of EGF-R transactivation., Cell surface expression of EGFR is associated with osteosarcoma pathogenesis, whole gene amplifications of egfr are rare in invasive breast cancer and explain protein overexpression in only about 12.5% of invasive breast cancer cases, epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes, The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy., PPARgamma and EGFR signalling have roles in urothelial terminal differentiation, EGFR regulation by E-cadherin was associated with complex formation between EGFR and E-cadherin that depended on the extracellular domain of E-cadherin but was independent of beta-catenin binding or p120-catenin binding, Intensive staining of EGF-R is associated with invasive tumours of bladder, Data show that epidermal growth factor receptor signaling results in phosphorylation of CUG-BP1, and leads to increased binding of CUG-BP1 to CCAAT/enhancer binding protein beta (C/EBP beta) mRNA and elevated expression of the C/EBPbeta LIP isoform., misfolding of the LDLR epidermal growth factor-AB pair results from low density lipoprotein receptor familial hypercholesterolemia mutations, A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib., somatic mutations of EGFR were found in 15 of 58 non-small cell lung cancer tumors from Japan and 1 of 61 from the United States; EGFR mutations may predict sensitivity to gefitinib, Results provide an explanation for cell surface receptor cross-talk involving the Met receptor and link G protein-coupled receptors and the epidermal growth factor receptor to the oncogenic potential of Met signaling in human carcinoma cells., P. 445, Overexpression of EGFR was observed in only a small fraction of colorectal carcinomas, but were frequently accompanied by gene amplification., the epidermal growth factor receptor has a role in activating ERK with extracellular oxidation by taurine chloramine, Endothelial cell vessel assembly requires EGFR signaling transduction pathways., Data demonstrate that at least four different sets of endogenously expressed gangliosides, including GD3, did not have a significant effect on epidermal growth factor receptor distribution in the plasma membrane., Statistically significant relation existed between the ovarian cancer metastatic potential and EGFR expression level., The overall time-dependent activation of EGFR autophosphorylation was identical in cells treated with 1 nm BTC or 1.5 nm EGF., EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells, resulting in increased cell-cell adhesion, The cytoplasmic overexpression of EGFr plays a significant role in the progression of pancreatic ductal adenocarcinoma, especially in the invasion and acquisition of aggressive clinical behavior., EGFR, PYK2, Yes, and SHP-2 are involved in transduction of the TF/FVIIa signal possibly via transactivation of the EGF receptor., epidermal growth factor receptor is dephosphorylated at endomembranes after ligand-mediated endocytosis, transactivation through CCR3 is a critical pathway that elicits mitogen-activated protein kinase activation and cytokine production in bronchial epithelial cells, trans-activation by calcium-sensing receptor, The tumor-specific mutation of epidermal growth factor receptor promotes cells survival and dimerization with the wild-type EGFR., EGF receptor traffic is disrupted by farnesyltransferase inhibitors through modulation of the RhoB GTPase, c-erbB-2 and EGF-R are overexpressed in breast neoplasms and have an inverse association with Estrogen Receptor expression, Human leukocyte elastase induces keratinocyte proliferation by proteolytic activation of an EGFR signaling cascade involving TGF-alpha., betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas., The epidermal growth factor receptor (EGFR) is one of signalling pathways activated during premalignant proliferative changes in the airway epithelium., an interrelationship is now known to exist between the IGF and EGF receptors [review], amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in normal keratinocytes, EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck, In each of these gliomas, the founding molecule was generated by a simple event that circularizes a chromosome fragment overlapping the epidermal growth factor receptor gene., novel mechanism by which IGF-I induces ERK activation in a manner that is dependent on the basal level of EGFR-TK activity, but is independent of receptor transactivation., Upregulation of leucine-rich repeats and immunoglobulin-like domains 1 is followed by enhanced ubiquitylation and degradation of EGFR, mutant EGFRs selectively transduce survival signals on which nonsmall cell lung cancers become dependent, Carbon black causes oxidative stress-mediated proliferation of airway epithelium, involving activation of EGF-R., IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway., EGFR signaling involves reinforcing altered gene expression of uPAR,thus further inducing cell motility., In patients with breast cancer, most CNS metastatic tumor deposits showed expression for either EGFR or HER-2/neu, and less often for both., Syk acts a negative control element of EGFR signalling., Data show that activation of ADAM-17 results in discrete cellular responses, while G protein-coupled receptor agonists promote activation of the Ras/MAPK pathway and cell proliferation via the epidermal growth factor receptor., The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor in mice is strongly dependent on genetic background., Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis., Results describe the role of epidermal growth factor receptor regulation in antiapoptosis, cell migration, and cell proliferation., Egfr Wa5 is a novel ENU-induced antimorphic allele caused by a kinase-dead receptor acting as a dominant negative, data explain how thrombin exerts robust trophic action on colon cancer cells and underline the critical role of EGFR transactivation, GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton., serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy, a novel regulatory role for Galphas in EGF receptor degradation and provide mechanistic insights into the function of Galphas in endocytic sorting, NHERF stabilizes EGFR at the cell surface and slows the rate of endocytosis without affecting recycling, EGF signalling amplification is induced by dynamic clustering of EGFR, analysis of conformations of the epidermal growth factor receptor and antibody binding [review], cholangiocarcinoma cells exhibit sustained EGFR activation due to defective receptor internalization, Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma)., regulation of LMP1 on the nuclear translocation of EGFR is critical for the process of nasopharyngeal carcinoma, For genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between systemic lupus erythematosus and controls. In addition, there was significant association between the two groups in allelic frequency of the T allele., Our results suggest a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function., role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells, protein kinase B/Akt phosphorylation is stimulated by mechanical stretch in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor, S1P transactivates c-Met and EGFR in gastric cancer cells., Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation, EGFR is increased by cAMP, a potent inducer of decidualization of the endometrial stroma., HER2-mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2-mediated amplification of epidermal growth factor-induced ERK signaling, therapeutic potential of siRNA to impact DeltaEGFR as a glioma-specific target, The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5., These results suggest that EGFR amplification is a relatively rare event in larynx carcinogenesis that obviously does not predispose to tumor progression., PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells, epidermal growth factor receptor interacts with gastrointestinal peptide hormone receptors to regulate mitogenic signaling and cell migration [review], High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness, Grb2-mediated recruitment of the functional RING domain of Cbl to the EGFR is essential and sufficient to support receptor endocytosis, the acceleration of EBV LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma, Data show that expression of epidermal growth factor receptors (EGFR) in transgenic mouse Schwann cells elicited features of neurofibromas, supporting the relevance of EGFR to peripheral nerve tumor formation., An inhibitor of this and of the mTOR pathwway inhibits growth of glioma in a xenograft mousse model., A common polymorphism in the EGFR promoter was associated with altered promoter activity and gene expression both in vitro and in vivo., In addition to EGFR mutations, other factors in non-small cell lung carcinoma cells, such as high expression of ErbB family members, may constitutively activate AKT and sensitize cells to EGFR inhibitors., Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation for prognosis of breast cancer., Cpd 5-caused ERK phosphorylation is probably regulated by both EGFR-dependent and EGFR-independent pathways., Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation, stimulation of the EGFR pathway is one mechanism by which the bone marrow microenvironment may contribute to the growth and survival of B-cell acute leukemia, Data suggest the possibility of a mechanically activated epidermal growth factor receptor (EGFR) autocrine feedback loop involving selected EGFR ligands., Tyr-992 and Tyr-1173 are required for phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2, EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in non-small cell lung cancers., YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway, HDL blocks neuroblastoma differentiation by inhibition of EGFR, Findings provide evidence that STAT 3 signal activity in head and neck carcinomas, which is partially responsible for proliferative activity, can be controlled via the EGFR., Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers., Findings suggest that a distinct minority of colorectal adenocarcinomas exhibit somatic mutations of EGFR, and these tumors may be susceptible to gefitinib treatment., The optimization and specification of therapeutic approaches based on erbB-receptor targeting requires to account for EGFR coexpression as well as the potential presence of erbB-receptor relevant growth factors., EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma, HB-EGF/HER-1 signaling is relevant to mesenchymal stem cell biology, by regulating both proliferation and differentiation, EGFR-related protein (ERRP) is a 53 to 55 kDa protein that is a natural inhibitor of EGFRs in human but not in mouse or rat cells., Increased levels of EGFR were significantly associated with adult soft tissue sarcomas, decreased EGF receptor tyrosine phosphorylation and aberrant recruitment of the adaptor proteins ShcA and Grb2 to the EGF receptor in cells harbouring the hepatitis C virus subgenomic replicon, Mutations in the tyrosine kinase domain of the epidermal growth factor receptor is associated with non-small cell lung cancer, data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression, p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation, regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells, data suggest that mutations of epidermal growth factor receptor (EGFR) and K-RAS genes might separately, but not cooperatively, contribute to lung adenocarcinoma pathogenesis, Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element., The membrane-anchoring domain of EGFR ligands dictates their ability to operate in juxtacrine mode., the EGF receptor plays a central role in the signaling pathway that links albumin to the activation of ERK1/ERK2 and increased expression of IL-8, Using the LightCycler PCR assay, the EGFR L858R mutation status might correlate with gender, pathologic subtypes, and gefitinib sensitivity of lung cancers., Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways, epidermal growth factor receptor is activated by imatinib mesylate, resulting in cyclooxygenase-2 induction and prostaglandin E2 accumulation, High EGFR gene copy number identified by FISH may be an effective molecular predictor for gefitinib efficacy in advanced NSCLC., heterogeneity in the density of EGFR due to localization in certain regions of the plasma membrane, which has been experimentally reported, can also lead to concave up shape of the Scatchard plot of the EGF binding on EGFR, autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation, analysis of EGFR mutations in malignant pleural effusion of non-small cell lung cancer (case report), Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules., These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer., Immunohistochemical profiling of colorectal cancer seems to be a promising approach, not only to define prognostic impact, but also to detail proliferation-related molecular interplays between EGFr and Cox-2 pathways., EGFR physically interacts with signal transducers and activators of transcription 3 in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase., Active mutation of the EGFR kinase domain was strongly associated with response to gefitinib, EGFR downregulation is inhibited by Sprouty2 targeting both the Cbl and CIN85 pathways., overexpression of the active form of the small GTPase RhoA induces the activation of Epidermal Growth Factor Receptor and promotes cell motility, EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery, Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells, Our findings suggest that extracellular H(2)O(2) generated by EGFR-ligand interaction permeates the plasma membrane and inhibits EGFR-associated tyrosine phosphatase activity., PTEN protein could inhibit cell invasion even in the presence of the constitutively active epidermal growth factor receptor(EGFR), Decorin causes EGFR internalization via caveolae, analysis of ligand-induced dimer-tetramer transition during the epidermal growth factor receptor activation of the cell surface, Data show that blockade of epidermal growth factor receptor import into the nucleus also blocks radiation-induced activation of DNA-PK, inhibits DNA repair, and increases radiosensitivity of treated cells., EGFR expression was associated with improved survival., Chromogenic in situ hybridization analysis and morphology identified 22 small cell (SCGBM) and 22 non-small cell glioblastoma (NSCGBM), and 12 cases of a mixed phenotype., Existence of unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II, acting through IGF-IR, regulates basal and ligand-activated EGFR signaling and cell proliferation in a c-SRC-dependent manner in tamoxifen-resistant breast cancer., analysis of activating mutations in catalytic domain of EGFR in 3.5% (2 of 57) of ovarian cancers, Overall, these data suggest that GRK2 has a regulatory role in EGF-induced ERK/MAPK activation., fibrin can support the wound healing process of the epidermis via the TGF-alpha/EGF-R pathway, results show that EGFR are present on normal human melanocytes, Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy., These findings suggest a mechanism by which filopodia detect the presence and concentration of effector molecules far from the cell body and mediate cellular responses via directed transport of activated receptors., This study suggests that coexpression of LN-5 gamma2 and EGFR is closely related to the progression and poor prognosis of esophageal SCC., The effects of high glucose on proximal tubular cells proliferation, reduced apoptosis and increased NHE3 mRNA levels are mediated by EGFR-dependent up-regulation of SGK-1., Data show that epidermal growth factor receptor dileucine motif 679-LL is an alpha-helical stabilizing motif that regulates a predominant step during lysosomal sorting, involving intracellular retention under both sub-saturating and saturating conditions., EGFR antisense-odn can significantly inhibit proliferation of human hepatoma cells, indicating that EGFR may play important role in development of hepatoma and will be new target for its treatment., EGFR signaling has a role in regulating host defense and immune response by tightly controlling TLR2 induction during bacterial infections, thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II, Two tyrosine residues in the C terminus of human TRPC4 phosphorylated following epidermal growth factor (EGF) receptor stimulation of COS-7 cells., findings suggest that overexpression of EGFR in glioblastomas in Chinese patients may be associated closely with the patients age but not with the tumors' pathological pathway., Overexpression of EGFR was significantly correlated with depth of invasion of the tumor, simulation results show the formation of a channel under Thr766 following the movement of the side chain of Gln767 away from the hinge in EGFR, The patients with mutations of EGFR to have a more favorable prognosis than those with wild type (p=0.033)., Intratumoral variation of epidermal growth factor receptor (EGFR) expression in glioblastoma multiforme was examined, and radionuclide labelled substances that bind specifically to EGFR were considered for intracavitary therapy., EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma, The mechanism of deoxycholic acid-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of amphiregulin release from the basolateral cell membrane., EGFR expression status in lung cancer correlates with its mutation., LPA acts upstream of various receptor tyrosine kinases and COX-2, and thus may act as a potent stimulator of colorectal cancer., the effect of interleukin-8 (IL-8) induced by H. pylori infection on EGFR transactivation and epithelial cell growth, The frequency of CA allele combinations was assessed in healthy women from Poland; results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation., the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells, EGF-R fate is controlled by a checkpoint downstream of receptor ubiquitination whose regulation by the Cbl RF tail may require Sprouty2 degradation., Acquisition of resistance to tyrosine kinase inhibitors in non-small cell lung cancer is linked to a specific secondary somatic mutation, EGFR T790M., These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization., RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes, Breast carcinomas with squamous differentiation are a distinct subgroup of breast tumors with a very high frequency of EGFR expression, Ubiquitination of EGFR at late stages of endocytosis was significantly lower than that in control cells. Highly ubiquitinated forms of EGFR demonstrated more sensitivity to MG132 treatment., RhoB is essential in regulating keratinocyte cell survival after UVB exposure through epidermal growth factor receptor signaling, EGFR expression and signaling does not seeme to be affected by treatment with erlotinib or gefitinib, rab7 regulates the endocytic trafficking of the EGF.EGFR complex by regulating its lysosomal degradation, Activation of erbB1 leads to phosphorylation of protein phosphatase 2A, inhibiting its activity, which provides a rapid means of sensing the loss of epithelial integrity and subsequently restoring barrier function., EGFR, in addition to E2F1, target sites induce B-Myb promoter, data suggest that the EGFR immunopositivity can be considered as reliable predictors of disease stage in urine ThinPrep (TP) specimens., data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer, In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation., spatially distributed Monte Carlo based simulation framework to enable the simulation of in vivo receptor diffusion and dimerization, These findings reveal a new role for EGFR in the postnatal brain and open new avenues to optimize cell engraftment for brain repair., Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in non-small cell lung cancer, The endogenous levels of EGFR in erosive oral lichen planus was significantly higher than those in reticular OLP and normal oral mucosa., EGFR mutations may contribute to the development of bronchioloaveolar carcinoma and are one of the early genetic alterations in multistage carcinogenic processes of lung adenocarcinoma, Theaflavin-3, 3'-digallate may exert chemopreventive effects through the downregulation of the EGFR., An EGFR mutant with four amino acid changes exhibited binding to the conformationally-specific monoclonal antibodies. and human epidermal growth factor, PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR., EGFR-induced signaling and Grb2 are essential for formation of clathrin-coated pits accommodating the EGFR, while activation of MAPK and PI3K is not required., Antibodies from naive human scFv (single-chain Fv) phage display libraries provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family., ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer, Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking, IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation, study provides a new insight into oncogenic signaling by EGFRvIII and improves our understanding of how autocrine loops are generated in glioma, Reactive Oxygen Species-induced Goblet Cell metaplasia in normal human bronchial epithelial cells is associated with Hyaluronan depolymerization and Epidermal Growth Factor (EGF) processing by Tissue Kallikrein followed by EGF Receptor signaling., phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor., Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells., Data show that long-term ciliated cell hyperplasia and activation of epidermal growth factor receptor signaling coincide with mucous cell metaplasia after respiratory viral clearance in airways., EGFR signaling pathway negatively regulates prostate specific antigen expression which may be induced by the alteration of androgen expression via the PI3K-Akt pathway in LNCaP C-81 cells, Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways., N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) can induce the clustering of epidermal growth factor receptor (EGFR) in human amnion FL cells., Data show that c-erbB-1 and c-erbB-2 are differentially regulated in cancers of the papilla of Vater and pancreas, suggesting that the two types of cancer are biologically different., Epidermal growth factor receptor gene mutation is associated with adenocarcinomas of the lung, In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation., The existence of mutations in the tyrosine kinase domain of the EGFR gene in a small subset of synovial sarcomas suggests that only few patients may profit from the tyrosine kinase inhibitor therapy., COX-2 and EGFR may be cooperative in the stepwise progression from Barrett's esophagus to adenocarcinoma, thereby leading to carcinogenesis., EGFR expression is not stable during metastatic progression in a significant proportion of non-small-cell-lung cancer patients., Understanding of EGFR identity in colorectal cancer which could be useful in reconsidering the predictive tools for the identification of tumors putatively responsive to EGFR targeted therapy., EGFR expression in bladder cancer cells was associated with up-regulation of ID-1 and cancer staging., The steric hindrance created by the antibody near the EGFR dimer interface interferes with receptor dimerization, and we postulate this as the structural origin for the antitumor effect of mAb 806., Epidermal growth factor receptor and KRAS mutation patterns is associated with non-small cell lung cancer patients, Taken together, these data provide direct evidence for the role of EGFR ubiquitination in receptor targeting to the lysosome and implicate Lys63-linked polyubiquitin chains in this sorting process., The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9., Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells., Data provide the first evidence of somatic mutations of the EGFR gene in bile duct carcinoma., Our work sheds light into the nature and regulation of the nuclear EGFR pathway and provides a plausible mechanism by which cells shuttle cell-surface EGFR and potentially other RTKs through the nuclear pore complex and into the nuclear compartment., EGFR mutation and gene amplification potentially have impact on the responsiveness to EGFR targeting agents in ovarian cancer., Mutations in EGFR is associated with Non-Small-Cell Lung Carcinoma, CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression, a wide spectrum of somatic EGFR TK mutations reporting a relatively high incidence (15%) in NSCLC patients of Greek and Czech origin., Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation., Salient features of the structural model for EGFR regulation and argue that the intramolecular tether provides only limited autoinhibitory control of EGFR activity., the trophic properties of gastrin in colorectal cancer may be mediated in part by transactivation of the EGFR and phosphorylation of ERK1/2, leading to degradation of PPARgamma protein and a decrease in PPARgamma activation, seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways, An EGF mutant, designated WVR/EGF/IADIQ, gained high affinity for ErbB3 & showed concomitant ErbB3 activation through ErbB2.ErbB3 heterodimers similar to the natural ErbB3 ligand NRG1beta, while the capacity to bind & activate ErbB1 was fully maintained., overexpression of epidermal growth factor receptor due to missense mutation and single nucleotide polymorphisms is associated with gastrointestinal tract tumor, Significant higher expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor are associated with neuroendocrine tumors, Circular dichroism spectroscopy indicated that the EGFR C-terminal domain possessed a significant level of secondary structure in the form of alpha-helices and beta-sheets, with a marginal change in beta-sheet content occurring upon phosphorylation., The Epidermal Growth Factor Receptor represent independents prognostic marker for intracranial ependymomas to identify patient subgroups with different risk profiles in further clinical investigations., The Increased expression of erbB-1 was associated with increased levels of Ki-67 and MCM2 expression, and combined overexpression of these receptors was associated with the highest levels of proliferation, suggesting a synergistic effect., High epidermal growth factor receptor is associated with disease recurrence in colon cancer patients, PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin and increased epidermal growth factor receptor (EGFR) endocytosis at physiological EGF concentrations., 96% of tumor samples were positive for EGFR expression; 63% were positive for activated EGFR; 76% were positive for activated Akt; and 96% were positive for activated ERK1/2., The aim of this review is the biology of the EGFR and its use as a target for a new class of anticancer agents for colorectal cancer.Results available so far demonstrated a manageable and acceptable toxicity profile and a promising level of activity., results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested, Frequent EGFR mutations is associated with brain metastases of lung adenocarcinoma, patients with mutant-type EGFR might be treated with EGFR-TKIs before any other drugs, the versican G3 domain regulates neuronal attachment, neurite outgrowth, and synaptic function of hippocampal neurons via EGFR-dependent and -independent signaling pathways, role for p38 MAP kinase in the regulation of EGFR endocytosis, Final outcome of bladder cancer patients with high HER1- and HER2-expressing tumors depends on the expression of HER3 AND HER4., RNa silencing had no inhibitory effect on cell proliferation, migration and activation status of EGFR-coupled signaling cascades in glioma cells., lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF, periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways, No change in expression levels of EGFR was seen in the histologic progression to esophageal adenocarcinoma., Gefitinib-sensitizing mutations in the EGFR gene were found in human esophageal tumors., EGF receptor trafficking and signaling occur through a subset of signaling molecules including p44/42 MAPK and Gab1., epidermal growth factor receptor (EGFR) has a role in head and neck cancer and its response to treatment [review], EGFR functions as control center & integration site for signaling processes, involving stimulation with EGF. It has 6 docking sites for Grb2 and is a direct binding partner of STAT5., EGF stimulates receptor neddylation, which enhances subsequent ubiquitylation, as well as sorting of EGFR for degradation, analysis of proteins that bind to and interact with EGFR, These findings are consistent with a model in which ErbB1 expression increases during development of the androgen-independent state. Drugs targeted toward ErbB signaling could be of therapeutic relevance in the management of advanced prostatic carcinoma., Results describe a relationship between the effects of epidermal growth factor (EGF) on cell proliferation and levels of EGF receptor expression in a cell line expressing different levels of EGFR caused by different concentrations of EGF treatment., The CDK/cyclin-like complex formed by two kinase domains thus explains the activation of EGFR-family receptors by homo- or heterodimerization., These data demonstrate that sterile wounding initiates an innate immune response through activation of the epidermal growth factor receptor that increases resistance to overt infection and microbial colonization., The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation., These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway., EGFRvIII expression may regulate phenotypic plasticity in ovarian cancer and thereby contribute to more aggressive disease, A subset of pancreatic ductal adenocarcinomas is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence)., The majority of oral squamous cell carcinomas highly express EGFR and p-EGFR, and a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion., Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor and plays a crucial role for regulating the amount of the EGF receptor on the cell surface membrane, Cell proliferation and expression of EGFR of tumor cells can be inhibited by transfection of CKLFSF8., Induction of keratinocyte migration is conveyed through EGFR, promoted by endogenous HB-EGF and requires GSK-3alpha activity., ERBB-1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma., Patients with non-small cell lung cancer and EGFR exon 19 deletions have a longer survival following treatment with gefitinib or erlotinib compared with those with the L858R mutation, the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors, Data show that decorin protein core inhibits tumor xenograft growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation., the disulfide-bonded structure of the membrane-proximal portion of the EGF receptor, rather than its primary sequence, is important for EGF binding and signaling but is not involved in localizing the receptor to lipid rafts, Significantly elevated epidermal growth factor receptor is associated with metastatic malignant melanoma patients with an inverse correlation between EGF-R and IL-6 levels., Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells., EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation, analysis of activating mutations within EGFR in both esophageal and pancreatic adenocarcinomas and a model of the role of EGFR signaling in neoplasms, These results demonstrate that both clathrin-positive and clathrin-negative electron dense coats exist on endosomes and are involved in endosomal sorting of the EGFR., epidermal growth factor receptor has a role in response to gefitinib treatment in patients with non-small cell lung cancer, The -216T allele was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25)., alterations within the tyrosine kinase domain and expression of EGFRvIII are rare events in bladder cancer, Data show that treatment of tumor cell lines with the epidermal growth factor receptor-specific inhibitor cetuximab results in paradox phosphorylation of tyrosine 1173 in the receptor., T790M mutation is sometimes present in a minor population of tumor cells during the development of non-small cell lung cancer., EGFRvIII and PTEN protein by glioblastoma cells is strongly associated with clinical response to EGFR kinase inhibitor therapy, EGFR somatic mutations directly influence both erlotinib cancer cell sensitivity and cellular transformation., ITSN forms a complex with Cbl in vivo mediated by the Src homology (SH) 3 domains binding to the Pro-rich COOH terminus of Cbl. This interaction stimulates the ubiquitylation and degradation of the activated EGFR., These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl., EGFR is required for UVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin., analysis of the mechanisms of action of EGFR-TK-inhibition in hepatocellular cancer cells by erlotinib, The EGFRvIII is expressed in HNSCC where it contributes to enhanced growth and resistance to targeting wild-type EGFR., EGFR and TrkB crosstalk each other in response to EGF and BDNF, leading to cell survival pathway activation in ovarian cancer cells., somatic mutations in EGFR quantitatively differ in pharmacology and signaling properties, different EGF receptor mutations exert various negative mechanisms that have the potential to modify receptor internalization and may involve resistance to tyrosine kinase inhibitors in cancers [EGFRvIII, EGF Receptor VIII], transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2), The findings of EGFR abnormalities in lung cancer have supported the notion that different molecular mechanisms and pathways are involved in the pathogenesis of lung cancer arising in never and ever smokers., IL-13 and EGFR pathways make critical but quite distinct contributions to gene regulation in airway epithelial cells, and that both pathways affect expression of the key transcription factor, FOXA2, a known regulator of mucus production., receptor stability is regulated by MUC1 expression, cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway, The phosphorylation sites that are most strongly correlated with migration & proliferation were identified, eg. EGFR Y1173 correlates with proliferation., activating mutations in the TKD domain of EGFR contribute to radiosensitivity of non-small-cell lung carcinoma, The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined., In midgut carcinoid tumor stroma PDGFRalpha was expressed in 35%, PDGFRbeta in 94% and EGFR in 9%., In this article, we review efforts that have been undertaken to identify genomic determinants of drug susceptibility to EGFR tyrosine kinase inhibitors, with particular focus on the role of gene mutations., fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway., the impacts of smoking and sex on the risk of EGFRmut non-small-cell lung cancers (NSCLC) are different from those for EGFRwt NSCLC, Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)[p145met], EGFR on the cell surface of cancer cells must exist as an untethered dimer that adopts a previously unreported conformation that is inactive which may provide synergy between monoclonal antibodies and AG1478 in a xenograft model., EGFR intron 1 polymorphism may influence response to treatment with tyrosine kinase inhibitors in breast cancer., The expression of EGFR in postmitotic, terminally differentiated adult retinal neurons suggests that EGFR has pleiotropic functions., EGFR polymorphisms may be associated with clinical outcome in patients treated with chemoradiation., UBPY-mediated EGFR de-ubiquitination promotes EGFR degradation, These results suggest that the secreted Hsp70 mediates the cross-communication of Toll like receptor and epidermal growth factor receptor signaling systems in A431 cells., Even a modest attenuation of EGF-R signaling leads to a severe defect in postnatal growth of the beta-cells, which leads to the development of diabetes in transgenic mice., EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations., N-linked glycan with GlcNAc termini linked to EGFR is the target to interact with ganglioside GM3, causing inhibition of EGF-induced EGFR tyrosine kinase, Since the EGF receptor is often overexpressed in skin cancers, it might be possible to significantly reduce the proliferative potential of these cells making them good targets for laser-pulsed UV light treatment., Mutations and amplification/overdose in the EGFR gene are present in low-grade oligodendroglial tumours, and may contribute to the development of these brain neoplasms., S100beta-v-erbB transgenic rats may serve as a useful animal model for the identification of EGFR-related molecular targets and as a tool for the assessment of novel therapeutic approaches., An inflammation-dependent EGF-R cascade causes overproduction of the gel-forming mucin MUC5AC, which accumulates in cholesterol gallstone disease. The ability to interrupt this cascade is of potential interest in the prevention of cholesterol gallstones., Inhibition of EGFR activity decreases cell migration involved in insulin-induced wound repair. Insulin stimulates wound healing in corneal epithelium by activating EGFR. This points to novel insulin signaling pathway during corneal wound healing., These findings unmask an EGF-sensitive checkpoint, helping to understand the link between sustained EGFR signalling, proliferation and the acquisition of a radioresistant phenotype in cancer cells., Review. Excessive EGFR signalling plays a critical role in NSCLC tumorigenesis in patients harbouring an EGFR mutation. Mutant EGFRs drive the growth of cancer cells & maintain their malignant phenotype by selective activation of Akt & STAT pathways., The EGFR protein was carried out in 71 of these cases, nonproliferative benign breast disease, proliferative BBD without atypia, proliferative BBD with atypia, carcinoma in situ (n=15) or invasive carcinoma., Results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma., Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins, Combined blockade of both epidermal growth factor receptors and G protein coupled recaptors (GPCRs) may be a strategy to treat cancers, including head and neck squamous cell carcinoma that shows cross-talk between GPCR and EGFR signaling pathways., These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR., EGFR positivity was observed in all the cases (100%) of benign prostatic hypertrophy (BPH) and prostatic intraepithelial neoplasia (PIN) and in only 10 cases (28.5%) of prostatic carcinoma., Epidermal growth factor receptor mutations are associated with adenosquamous carcinoma of the lung, EGFR gene amplification is frequently present in prostatic phyllodes tumors in humans., Motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44, whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3., somatic alterations in p53 and EGFR have roles in progression of primary lung cancer, EGFR gene mutation does not change the effect of gefitinib in non-small cell lung cancer cells, EGFRvIII mutation in lung cancer is correlated with increased expression of EGFR, Detailed pharmacokinetic characterization of this bioprobe could assist in the development of a kinetic model that would afford accurate measurement of EGFR content in tumors., Overexpression of epidermal growth factor receptor is associated with esophageal and esophagogastric junction adenocarcinomas, These results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms., This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon., The number of dinucleotide repeats in this receptor identifies a possible susceptible population to lung cancer., long term treatment with epidermal growth factor (EGF) leads to a marked increase in the levels of ADAM17, which also increases the shedding of several substrates of ADAM17, including the desmosomal cadherin Dsg-2, W-13 calmodulin inhibitor has a role in epidermal growth factor receptor activation, EGFR targeted strategies for pancreatic cancer, The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells., To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brain tumors, and to evaluate their prognostic significance., Directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation., Mutations in epidermal growth factor receptor is associated with lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas, PTEN tumor-suppressor protein has a role in response to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma, Estradiol receptor alpha and androgen receptor upregulate EGFR phosphorylation., Targeting of EGFR to determine molecular alterations of this gene may be useful in the management of patients with brain metastases., Overexpression of the EGFR is associated with astrocytomas, Data suggest that mutation frequency of EGFR in NSCLCs from Chinese patients is higher than that of western ethnicities, such mutations are well correlated with tumor response to gefitinib, and gefitinib is more fit for Chinese NSCLC patients., EGFR overexpression in small cell carcinoma of the urinary bladder does not seem to be caused by gene amplification, Our results show EGFR mutations did not occur in these patients suggesting that gefitinib is unlikely to be effective in patients with tumors not harboring specific EGFR TK domain., These data imply that PARP activation following exposure to ionizing radiation is enhanced through EGFR-ERK signaling., EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation., Conventional PKC isoforms, especially PKCalpha, mediate feedback inhibition of G-protein-coupled receptor -induced EGFR transactivation., No siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma., Tenascin C repeat Ten14 in monomeric form does not bind EGFR with sufficient stability so as to induce degradation of receptor, or undergo EGFR-mediated internalization over either the short (20 min) or long (48 h) term, Aldosterone leads to enhanced EGFR expression via interaction with EGFR promoter, which is mineralocorticoid receptor specific and could contribute to the aldosterone-induced increase in fibronectin abundance., EGFR signaling is controlled by a novel mechanism involving trafficking-dependent alterations in receptor compartmentalization., EGFR cannot compensate for IGF1R depletion., Findings suggest that the EGFR mutation is frequent in Korean lung cancer patients., Alterations in PTEN and amplification of EGFR are uncommon in pediatric malignant gliomas, in contrast to adult malignant gliomas., overexpression of spartin results in a prominent decrease in EGFR degradation, In a novel culture system normal human adult melanocytes expressed both EGF receptor (EGFR) mRNA and protein and EGF showed a dose dependent mitogenic effect on the cells, decorin is taken up by more than one endocytic pathway; uptake depends on EGFR signaling rather than trafficking along the same pathway, The presence of EGFR mutations had no effect on survival., protein-tyrosine phosphatase 1B governs differential recruitment of signaling pathways involved in EGFR regulation of epithelial ion transport., integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, reactive oxygen species production, and excessive collagen synthesis, GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors., incidence of somatic mutations in the tyrosine kinase domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival of pancreatic adenocarcinoma patients, This study is the first to demonstrate that EGFR is implicated in IFNgamma-dependent signaling pathways., Analysis of tumor EGFR mutations in patients with NSCLC could be used to identify patients suitable for treatment with gefitinib to obtain optimum response and disease control rates., EGFR is hypermethylated and silenced in a subset of solid tumor cell lines and primary tumor specimens, and cotreatment with decitabine and gefitinib has an additive effect only in EGFR methylated breast cancer cell lines., the long lifetime of EGFRvIII, mutant variant of EGFR is caused by inefficient internalization and impaired sorting to lysosomes due to lack of effective ubiquitinylation., REVIEW, Describe association between EGFR polymorphisms and geftinib treatment outcome and toxicity in non-small-cell lung cancer patients., Results show epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding., Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported., analysis of specimens from patients with cancer of unknown primary for EGFR gene mutation, gene amplification, transcriptional regulation as well as protein expression, Rin1 regulates EGFR degradation in cooperation with STAM, There is a distinct clinical profile for NSCLC patients with the EGFR mutation, Our findings suggest that the balance between hepsin and its inhibitor, HAI-2, may have prognostic value in RCC., propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement, Inhibition of the EGFR signaling pathway reduces ductal carcinoma in situ mammosphere-forming efficiency., present results suggest that it is not a useful indicator of prognosis in oral squamous cell carcinoma, KRT17 is upregulated after radical prostatectomy for prostatic neoplasms., Potentially interesting value of the serum levels of sEGFR and EGF, especially when combined, as markers for non-small cell lung cancer and head and neck cancer., Shorter EGFR intron 1 CA repeat length is associated with worse pancreatic cancer clinical prognosis and in vitro response to erlotinib., Role of lipid rafts in EGFR-mediated cancer cell chemotaxis., Mutations in the EGFR tyrosine kinase domain correlate with the clinical response to Gefitinib in lung cancer patients., examinination of distributions of three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers, Frequencies of EGFR mutations were similar in both the alveolar and bronchial types of lung cancer, These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity., Significant increases in EGFR copy number and EGFR immunoreactivity were found in areca-associated oral squamous cell carcinoma subjects, Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK pathways., These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14., Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk., Targeting EGFR is a novel strategy against neuroblastoma., Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling, results suggest the majority of gain-of-function mutations within kinase genes in the EGFR signaling pathway have already been identified. Our findings also implicate FGFR4 in the pathogenesis of a subset of lung adenocarcinomas, EGFR pathway, EGFR mutation and/or amplification, may be involved in lung carcinogenesis., Results show a a significant correlation between the EGFR L858R mutation and the expression of p-Akt and suggest that the activation of Akt is dependent on EGFR mutation pattern., Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways., EGFR/Akt pathway mitigated G2/M arrest in human HaCaT keratinocytes and normal human keratinocytes treated with low doses of UVA irradiation., EGFR mutations in exon 21 are early events in small bronchiolalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types., Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients., Two somatic alterations (E829E and R831C) were identified in the cytoplasmic domain of the EGFR gene in 1 of 10 osteosarcoma samples., observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer, In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression., EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system., E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells, In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC, Results demonstrate that ErbB1 signaling is hyperactive in squamous cell carcinoma cells, but not basal cell carcinoma cells., it is suggested that atypical adenomatous hyperplasia (AAH) could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer, delE746-A750+L858R double activating EGFR mutations exist in Chinese non-small cell lung cancer patients and both locate on the same allele, Infection of AGS cells by H. pylori significantly increased EGFR mRNA and protein levels., EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5, epidermal growth factor receptor D761Y mutation has a role in response to tyrosine kinase inhibitors, Study has identified a subset of naturally occurring EGFR mutations that lack a critical radioprotective function of EGFR, providing valuable insights on how the EGFR mediates cell survival in response to radiation in NSCLC cell lines., Somatic mutation in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene is associated with the sensitivity of non-smal cell lung cancer (NSCLC) to TK inhibitor Gefitinib., Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38, Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC., MIP-3alpha-mediated ERK1/2 activation in Caco-2 cells appeared to require metalloproteinase-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR., Overexpression of EGFR and HER-2 is associated with pancreatic ductal adenocarcinoma, Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas, Although EGFR mutations appeared to be partially associated with the early steps of adenocarcinoma development, such mutations may possibly occur randomly even in multiple lesions in a single patient, The expression of EGFR may be associated with postoperative recurrence of Dukes'A and B colorectal carcinoma., Shiga toxin trafficking to the Golgi is controlled by several Rab GAPs and their target Rabs and this process is discrete from ligand-induced EGFR trafficking. RabGAP-5 was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin, It seems that continued EGFR tyrosine kinase inhibition may be beneficial to EGFR-mutant lung cancers., EGFR mutation can easily be detected in metastatic lymph nodes sampled by EBUS-TBNA., study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking, the R497K polymorphism of the EGFR could be a key determinant for reduced tumor recurrence and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma, among adenocarcinomas, nonmucinous and mucinous bronchioloalveolar carcinoma components were significantly associated with EGFR and K-ras gene mutations, respectively, Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer., In bronchioalveolar carcinoma/adenocarcinoma with bronchioalveolar features mucinous differentiation was significantly correlated with the absence of EGFR mutation and presence of KRAS mutation., Amplification of the EGFR gene and polysomy 7 are frequent alterations in primary melanomas and are associated with bad prognosis, OSU-03012 prevents YBX1 from inducing EGFR., EGFR and K-ras mutations may have a role in progression of resected non-small-cell lung cancer, In Chinese lung cancer patients, a low number of CA repeats in intron 1 of the EGF receptor gene is associated with a better clinical outcome during therapy with gefitinib., EGFR signalling plays a central role in cyclooxygenase-2 induction by transforming growth factor-beta 1 in human bronchial epithelial cells., EGFR mutations were therefore significantly associated with a better PFS in the first-line cytotoxic chemotherapy regimens., In NSCLC cases with wt- or mutant KRAS, downregulation of EGFR expression was a rare event although upregulation in bone metastases was observed more frequently in wt K-RAS cases., Decreased intratumoral EGFR expression and the absence of activated EGFR suggests that EGFR inhibition might not be an ideal target for antibody therapy., EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3, endothelin A receptor and epidermal growth factor receptor are targeted by the combination of ZD4054 and gefitinib in ovarian carcinoma, EGCG inhibits the binding of EGF to the EGFR and the subsequent dimerization and activation of the EGFR by altering membrane organization, EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas., The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression., Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib., ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell, Increased expression of erbB3 may play an additional role in non-small-cell lung carcinomas especially in female, nonsmoker, adenocarcinoma, and with EGFR gene mutation., EGFR was associated to disease-free survival for breast cancer patients treated with 2 years of adjuvant tamoxifen., data suggest that ligand release-independent transactivation of EGFR may diversify early TGF-beta signaling and represent a novel pathway leading to TGF-beta-mediated gene expression., GM3 has an effect on kinase associated with EGFR, Fluorescence in situ hybridization/immunohistochemistry analysis of EGFR may be a useful ancillary tool to classify difficult cytology cases and inform clinicians arranging targeted chemotherapy., No correlation between epidermal growth factor receptor protein overexpression and epidermal growth factor receptor gene amplification in gastrointestinal stromal tumors., HGF induces transactivation of the EGFR in epithelial cells, and this is a prerequisite for induction of full motility., Adenin/guanine polymorphisms are not associated with endometrial cancer in a Japanese population., EGFR mutation and gene amplification is asociated with clear cell sarcoma of the kidney, activating phosphorylation site on the c-Met receptor was found to be highly responsive to EGFRvIII levels, indicating cross-activation of the c-Met receptor tyrosine kinase by EGFRvIII, acquired resistance against both erlotinib, as well as gefitinib was most likely a result of tumor cells acquiring the T790M mutations, CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term., These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities., Treatment with either SP600125, a specific chemical inhibitor of JNK, or the expression of a dominant-negative JNK form inhibited autocrine production of uPA and HB-EGF, which block EGFR phosphorylation and mitigates invasive capacity., In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation., When combining thymidylate synthase and epidermal growth factor A61G genotype analysis, a small subgroup with a complete pathologic response rate of 100 percent was identified., Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation, CISH (chromogenic in situ hybridization) is an alternative assay to FISH in determining EGFR copy number., Expression rates of EGFR and Ki-67 in squamous cell carcinoma of nasal cavity and paranasal sinuses were significantly higher than that in nasal inverted papilloma and nasal polyps., study investigated EGFR protein expression & gene mutations in exons 18, 19 and 21 in 40 renal angiomyolipomas (AML); no EGFR gene mutations of TK domain were detected and strong immunostaining was found in 5% of the renal AML cases, EGFR insertion mutation in exon 20 could not be ignored from Japanese lung cancers, study found that EGFR down-regulation was impaired in two non-small cell lung cancers with EGFR tyrosine kinase domain mutations; the mutant receptors were poorly ubiquitylated and exhibited decreased association with the ubiquitin ligase Cbl, Reduction of sperm motility by tryptase through the PAR-2 receptor involves epidermal growth factor receptor pathways., EGFR may play an important role in the pathogenesis and phenotype of Congenital cystic airway malformation/congenital pulmonary airway malformation., EGFR immunoreactivity with basal cytoplasmic pattern was exclusively seen in terminal respiratory unit type lung adenocarcinoma and a subset of these cases was seen with EGFR mutations in the responders to EGFR inhibitor therapy, EGFR mutation status influenced the effect of adjuvant chemotherapy with uracil-tegafur., Regarding EGFR, no specific mutation was detected in five of the six patients with lung cancer whereas one female patient who had never smoked had a missense mutation., Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance., Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine., Overexpression of EGFR is associated with astrocytic tumor pathogenesis and progression, results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands, Protein expression and/or increased gene copy number of EGFR is common in colorectal carcinomas but unrelated to pathological features., EGFR mutations appear to occur in highly selected subgroups of lung cancer patients, TAE226-induced apoptosis in breast cancer cells with overexpressed EGFR., The Egfr+2073 A/T polymorphism is not associated with an increased risk of endometriosis in a Japanese population., The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR., induction of p50/p50/Bcl-3 complexes by latent membrane protein 1 (LMP1) C-terminal activating region 1 mediates LMP1-induced epidermal growth factor receptor upregulation, These results suggest that electric signals might play a role in metastasis of breast cancers by enhancing cell migration through the epidermal growth factor receptor signalling pathway., upregulation of EGFR expression in a few warty and basaloid HG-VIN cases and in many SCCs of the vulva., We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation, sex and smoking status could influence the EGFR mutational spectrum, the novel secreted ErbB1 isoforms may have functions distinct from the plasma membrane receptor, This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets., Inhibitory activity of cetuximab on epidermal growth factor receptor mutations is associated with non small cell lung cancers, EGFR mutations do not have significant prognostic value in primary resected non-small cell lung cancer, curcumin and FOLFOX work through attenuation of the EGFR and IGF-1R signaling pathways, EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells, The presence of neuroendocrine cells may have an effect on the expression of TGF-alpha and EGFR in gastric adenocarcinoma, and the autocrine mechanism between TGF-alpha and EGFR plays an important role in the prognosis of gastric carcinoma., CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation, SHH and EGFR signal pathways are active in pancreatic carcinoma, and are closely correlated to cancer cell proliferation. SHH and EGFR expression were positively correlated to PCNA expression., EGFR gene amplification or protein expression is not a predictor of gefitinib efficacy in Japanese patients with non-small-cell lung cancer, The serum CEA level appears to be closely associated with the presence of EGFR gene mutations in patients with pulmonary adenocarcinomas., Amphiregulin is a specific ligand of the EGFR and a potent mitogen for epithelial cells such as breast cancer cell lines., Wnt and epidermal growth factor receptor signaling pathways are altered through aberrant methylation and mutation in non small cell lung cancer, Absence of epidermal growth factor receptor mutations in cervical cancer., Increased EGFR gene copy number and elevated EGF levels are present in a significant proportion of pancreatic cancer patients, and this may reflect increased EGFR pathway dependence with improved sensitivity to EGFR-targeted therapy., These results suggest that the EGFR polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer., EGFR plays a role in the initiation of ovarian and uterine cancer and supported previous studies in breast cancer that the receptor can contribute to the neoplastic process in a significant albeit incremental way., No previouly described somatic EGFR mutations were found in head and neck squamous cell carcinoma DNA, but other DNA sequence variations were found in 9 of 31 patients. Activating EGFR mutations seem to be a rare event in Spanish HNSCC patients., we have shown no expression of ErbB-1 in vestibular schwannomas, Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas., The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation., This is the first time EGFR expression has been tracked meaningfully and developmentally from the normal condition through disease progression using in vitro, xenograft, and matched normal and tumor samples., examination of rate of association reactions between Grb2 and epidermal growth factor receptor, CONCLUSION, The clinical relevance of 'other' EGFR mutation variants remains uncertain and requires further assessment., EGFR expression, mutations, polymorphisms, and gene amplification contribute to to the pharmacodynamics of EGFR inhibitors., glioblastomas with EGFR gene amplification invariably exhibited EGFR overexpression at the level of the whole tumor, tumor cells with EGFR gene amplification did not always show EGFR overexpression at the level of individual tumor cells, Antitumor mechanisms of systemically administered EGFR antisense nucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck is reported., Up-regulation of the EGFR cascade may have an important role regarding mucus production in the sinus mucosa of patients with CRS and CRS/NP associated with hyperplasia and metaplasia of epithelial goblet cells, The activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation., elucidated genes not previously associated with EGFR-mutant NSCLC, two of which enhanced the clonogenicity of these cells, distinguishing these mediators from others previously shown to maintain cell survival, Amplifications within regulatory sequences of egfr are associated with the expression of eps15 and caveolin-1; EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK seems to present a major molecular pathway in progression of breast phyllodes tumours., AP-1 and NF-kappaB transcription factors are activated and EGF-R is expressed in these cells and associated with COX-2 and VEGF production., more than half of the EGFR population is present in membrane rafts and smaller percentages are present in caveolae and clathrin-coated pits, amphiregulin-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes, Epidermal growth factor receptor overexpression was significantly associated with subsequent metastasis and was found to be an independent prognostic factor for metastasis, The epidermal growth factor-receptor (EGF-R) is a receptor tyrosine kinase of the ErbB family. The increased immunoreactivity of EGF was detected in serous-mucinous adenocarcinoma of the ovary., These results highlight a role of P2Y(1)R in EGFR-dependent epithelial cell proliferation. P2Y(1)R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage., EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment., investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas, TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes, This study demonstrates that ADV-Avi/biotin-PEG-EGF construct systems can be applied for cell-specific delivery of ADV with simultaneously reducing innate immune responses., Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy., EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma., EGFR mutations were frequently found in lung adenocarcinoma with ground-glass opacity (GGO) on High-Resolution CT in this study., development of PF00299804 as treatment for cancers with mutations and/or amplifications of ERBB family members., MET amplification occurs independently of EGFR(T790M) mutations in lung adenocarcinoma, glioma tissue harbored numerical aberrations of the epidermal growth factor receptor gene, whereas no abnormality could be observed in necrosis or in nonglioma gliosis, heterozygous and synonymous transition of the EGFR gene and low EGFR expression levels of mRNA and protein in squamous cell carcinomas of the head and neck (SCCHN) may be reliable predictors of high sensitivity in SCCHN patients to gefitinib., clinical data suggesting that there could be a subpopulation of metastatic colorectal cancer patients that are more liable to benefit from anti-EGFR monoclonal antibodies--REVIEW, Overexpression of EGFR in lung adenocarcinomas with components of BAC histology correlate with never-smoker status and improved overall survival and disease-free interval., AC dinucleotide repeat polymorphism in intron 1 of human EGFR may have a role in breast cancer in certain ethnic groups, EGFR mutations and the administration of EGFR tyrosine kinase inhibitors during Whole-brain radiation therapy (WBRT) were independent predictors of response to WBRT in brain metastases of lung adenocarcinoma., EGFR overexpression was found in 87.5% (35/40) of the laryngeal primary tumors and 82.5% (33/40) of the corresponding lymph node metastases. There was a good agreement between the primary tumors and the paired metastases regarding EGFR expression., Epidermal growth factor receptor and protein kinase C signaling to ERK2, oncogenic EGFR and c-Met have roles in pathways mediating drug response, Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer., EGFR mutations in carcinogenesis of lung adenocarcinoma, EGFR structural alterations are rare in gastric carcinoma, but whenever present, it leads to tumour growth., Cell line genetic heterogeneity and/or multiple determinants modulate the role played by EGFR/HER2 in regulating cell proliferation., These findings implicate the ErbB pathway in vestibular schwannoma growth, Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma., EGFR overexpression is present in a majority of hepatocellular carcinomas, suggesting a role for EGFR antagonists in therapy. The increased expression does not correlate with an increase in the EGFR gene copy number., examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy, EGFR activation is the cause of both hyperplastic growth and VDR reduction in secondary parathyroidism hyperplasia, EGFR mutation is not associated with cutaneous melanoma, In human uterine leiomyomas, EGFR were also overexpressed., EGFR protein is up-regulated in the inverted papilloma, and both synchronous and metachronous carcinoma with inverted papilloma of the nasal cavity, suggesting EGFR is involved in the transformation from inverted papilloma to squamous cell carcinoma., Stimulating human glioblastoma cells with recombinant HGF induces biologically relevant EGFR activation., Conclude that selected bile acids modulate intestinal permeability via EGF receptor autophosphorylation, occludin dephosphorylation, and rearrangement at the tight junction level., The population of tumor cells with polysomy of chromosome 7 and EGFR locus correlated significantly with histological grade. High-grade astrocytomas (AAs and GBMs) had elevated fractions of tumor cells with polysomy of chromosome 7 and EGFR locus., study describes activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin, Nanoprobe assay may permit quantifiable and repetitive imaging of EGFR expression in colorectal cancer., Results demonstrate the physical and functional association of CD9 with epidermal growth factor receptor on MKN-28 cells., Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells., study found that EGFR high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by immunohistochemistry, These data indicate that PTHrP contributes to the malignancy of oral cancers downstream of EGFR signaling, and may thus provide a therapeutic target for oral cancer., cases of primary lung carcinoma were analyzed for correlations between the presence of somatic mutations of the epidermal growth factor receptor (EGFR) gene and the phosphorylation status of EGFR., These data suggest that Ack1 is involved in an early step of EGFR desensitization., EGFR mutations are associated with a significantly higher response rate and longer duration of response following treatment with EGFR TKIs, Neither EGFR nor BMI-1 had significant prognostic impact for basal-like phenotype of breast cancer., large-scale database to discriminate the survival impact of EGFR mutations against those of sex and smoking after gefitinib therapy., Here we show that epidermal growth factor (EGF) and heregulin induce CD44 shedding in JIMT-1, an ErbB2-overexpressing cell line resistant to trastuzumab, accompanied by internalization and intramembrane proteolysis of CD44 and enhanced cellular motility, Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection., Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling., MUC5AC is over-expressed in gallstone disease, despite the decrease in the expression of EGFR mRNA., no association was apparent between EGFR expression and highly polymorphic simple sequence repeat in intron 1 (CA-SSR I) status in colorectal tumors or normal tissues, Following ligand binding and receptor activation, EGFR is endocytosed and transported to lysosomes where the receptor is degraded, and this downregulation of EGFR is a complex and tightly regulated process., Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling., GPR30 has a role in breast tumor metastasis and transactivation of the epidermal growth factor receptor, Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells., EGFR gene mutation and amplification occurred frequently in advanced prostate cancer cases., first direct comparison of survival of resected patients with either EGFR or KRAS mutant lung adenocarcinomas compared with those wild type for both genes; EGFR & KRAS mutations define distinct molecular subsets of resected lung adenocarcinoma, Increased EGFR copy number was highly correlated with EGFR mutation in NSCLC patients, but less correlated with TKI responsiveness and the overall survival compared with EGFR mutations., microRNA-128b directly regulates EGFR,however EGFR expression and mutation status did not correlate with survival outcome., Nuclear accumulation of EGFR plays a key role in iNOS expression and resultant DNA damage, leading to EBV-mediated Naso-Pharyngeal Carcinoma(NPC)., These findings indicate that EGFR plays an important role in the maintenance of goblet cell hyperplasia., These data implicate RME-8 in sorting decisions influencing EGFR at the level of endosomes and point to RME-8 as a potential regulatory target in ErbB2-positive breast cancers., The results implicated that activated EGFR molecules associated with clathrin-coated pits but not caveolae at low doses of EGF, whereas they were located in these two domains at high EGF doses., Quantitative PCR analysis performed to determine the gene copy number of EGFR relative to that of a control gene (VEST1) did not detect increases in EGFR gene copy number among all patients evaluable for efficacy., Patients with advanced NSCLC who are life long never-smokers, those with EGFR TK mutations, and those with bronchioloalveolar cell carcinoma histology seem to have promising efficacy with first-line therapy with EGFR TKIs, EGFR mutations are frequently found in female, nonsmoker patients with adenocarcinoma suggests that some genetic predisposition causes the mutations in the EGFR gene, which result in carcinogenesis and maintenance of lung cancer., Molecular analysis of the primary and a liver metastasis did neither find any EGF-R mutation nor an EGF-R amplification., Altered growth factor receptor trafficking and GTP-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans, siRNA-mediated knockdown is effective in lung adenocarcinomas with EGFR mutation and those with resistance to gefitinib by acquired mutation in EGFR., U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition.[EGFRVIII], Epidermal growth factor receptor mutation might be a very early event in the pathogenesis of adenocarcinoma of the lung., In stage III non-small cell lung cancer, there was a significant association between TTF-1 and EGFR, the crosstalk between genotropic and non-genotropic AR signalling interferes with signalling of EGFR in response to ligand leading to a lower invasive phenotype of AR-positive PCa cells [review], Notch-1 upregulates EGFR expression and also demonstrate Notch-1 regulation of p53 in gliomas., PAR1-stimulated EGFR and ErbB2 transactivation leads to prolonged extracellular signal-regulated kinase-1 and -2 signaling and promotes breast carcinoma cell invasion., allelic somatic doublet mutations are present at high frequency in the epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain in lung cancers, These data identify an inhibitory action of AR on EGFR signaling, and support research investigating AR/EGFR antagonism in the treatment of ovarian cancers., HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways, EGFR and KRAS mutations occur early during the multistage pathogenesis of peripheral lung adenocarcinomas, Patients with T790M EGFR mutation may still response to erlotinib after gefitinib treatment failure, EGFR mutation is associated with Long-lasting complete remission with tyrosine kinase inhibitor in bronchioloalveolar carcinoma, Gene amplification of EGFR was found in 11 lung cancers. Nine of the cancers showed heterogeneous distribution, and amplification was associated with higher histologic grade or invasive growth., overexpression of JKTBP1 in LNCaP cells leads to abnormal cell proliferation, Our data suggest that EGFR mutations are associated with papillary adenocarcinoma lung cancer, acute loss of p53 in normal HKc induces EGFR expression by a mechanism that involves YY1 and Sp1 and does not require p53 binding to the EGFR promoter, In malignant pleural mesothelioma, epidermal growth factor receptor to play a role in a limited subset of patients, The results lead to the conclusion that the interaction between ABD1 and ABD2 and actin during EGF-induced signal transduction, and thus between EGFR and actin, are important in cell activation., EGFR and HPV demonstrate a significant correlation with genesis and progression of cervical carcinoma., EGFR overexpression was observed in a subset of cases with gastric carcinoma and was associated with an unfavourable prognosis., study reports on the associations of EGFR mutation, amplification, and protein expression in non-small cell lung cancer, non-small cell lung cancer patients with exon 19 deletions survived longer following gefitinib treatment than those with exon 21 point mutations, BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR and HER2, potently suppresses the kinase activity of wild-type and activated EGFR and HER2 mutants., Coordinated overexpression of the EGFR pathway predicts susceptibility to EGFR inhibitors in pancreatic cancer transplanted into nude mice., Functional EGFR polymorphisms is an independent prognostic markers of survival in metastatic colon cancer and is gender dependent., The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor HKI-272, high EGFR copy number via aneusomy is associated with metaplastic breast carcinoma, 15 Chinese NSCLC patients (62.5%, 15/24) harbored EGFR mutations which included deletion mutations in exon 19 and missense mutations in exon 21., Exon 19 of EGFR mutation and CA-repeat polymorphism in intron 1 is associated with lung cancer, HER1 showed significantly increased expression in differentiated thyroid cancer, Results show that EGFRvIII can be 'shared' between glioma cells by intercellular transfer of membrane-derived microvesicles ('oncosomes')., Epidermal growth factor receptor mutations are associated with non-small-cell lung cancers, Sensitive detection of EGFR gene mutations in purified genomic DNA from mixed cell populations., in response to EGF, active MT1-MMP is directed to the leading edge of migrating cells along micropatterned fibronectin stripes, in tandem with the local accumulation of the EGF receptor, EGFR overexpression is involved in the pathogenesis of phyllodes tumors, Women with two short CA repeats (<19)in EGFR are at a significantly higher risk of breast cancer. Women with short alleles (< 19) had much greater risk of developing cancer before the age of 55., Somatic mutations of EGFR or KIT of the thymomas and thymic carcinomas are presented in a small number of patients., Hepatitis E pORF3 localizes to early and recycling endosomes and causes a delay in the postinternalization trafficking of epidermal growth factor receptor (EGFR) to late endosomes/lysosomes., The researchers investigated the expression of epidermal growth factor receptors in synovial sarcomas and found no associated mutations in EGFR genomic sequences., EGFR mutations contribute to the acquisition of malignant potential in the AAH-AD sequence and occur independently in each lesion and in multicentric AD, BAC and AAH., Some lung adenocarcinomas may demonstrate intratumoral heterogeneity for the occurance of EGFR mutation., Delivery of gemcitabine to tumor cells can be improved by using EGF receptor-targeted immunoliposomes., EGFR gene mutations are frequently seen in lung adenocarcinomas with bronchioloalveolar differentiation and can be linked to chromosomal imbalances and increased VEGF expression, A Met/c-Src-mediated signaling pathway is a mediator of EGFR tyrosine phosphorylation and cell growth in the presence of EGFR TKIs., EGFR blockade combined with conventional chemotherapy results in anti-human soft tissue sarcomas (STS)activity in vitro and in vivo, suggesting the possibility that combining these synergistic treatments will improve anti-STS therapy., Mutations in the epidermal growth factor receptor correlate with increased response in patients with non-small-cell lung cancer treated with EGFR tyrosine kinase inhibitors, EGF transregulates opioid receptors through EGFR-mediated tyrosyl phosphorylation and activation of GRK2; GRK2 may be a mediator of cross-talk from RTK to GPCR signaling pathway, igh frequency of EGFR expression in osteosarcomas is associated with predominantly short alleles of EGFR-CA SSR, Phosphorylated epidermal growth factor receptor is associated with tumor-associated endothelialcells in the colon, Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor., Novel EGFR mutation D1012H and polymorphism at exon 25 is associated with lung cancer., Phosphorylation of EGFR is related with metastasis-free survival of nasopharyngeal carcinoma patients., ADAM17 mediates the EGFR/AKT/cyclin D1 pathway and cell cycle progression to the S phase induced by UVA radiation, EGFR expression was found in in 55 (63%) of patients with gastric cancer, Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib, a critical role for a EGF-R-connected p60c-src-kinase-mediated pathway involving STAT3 and contributing to cell survival and proliferation within colorectal carcinomatumours., We characterized, for the first time, EGFR molecular alterations in Portuguese patients with malignant glioma, We found a higher protein expression of EGF-R in human heptic cirrhosis (HC) tissues, suggesting that there was autocrine circulation of EGF-R in HC tissues., These results indicate the possibility of designing BTC mutants, which have an activity of inducing differentiation only, without facilitating growth promotion., epidermal growth factor receptor gene mutations may have roles in malignant pleural effusion of lung adenocarcinoma, there is a role of the EGFR gene, now as a target of miRNA regulation in lung cancer, Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation, EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy, EGFR contributes to RET kinase activation, signaling, and growth stimulation and may therefore be an attractive therapeutic target in RET-induced neoplasms, EGFRvIII is not a part of the malignant phenotype in ovarian cancer, The p-EGFR, the EGFR/pEGFR phenotype has a role in progerssion of invasive breast cancer, Present in some gastrointestinal stromal tumors, especially in small gastric tumors, and might participate in the growth regulation of human gastrointestinal stromal tumors., We screened for mutations in exons 18 to 21 of the EGFR gene in head and neck squamous cell patients. The otherwise rare EGFR mutation p.G796S occurred in 2 patients with HNSCC, Jab1 is a target of EGFR signaling in ERalpha- cell lines and breast tumors, EGFR is often expressed in thymic epithelial tumors and as such may prove to be a potential therapeutic target., EGFR-tyrosine kinase polymorphism might be associated with clinicopathological background of lung cancers., These results provide insight into a glutamate-induced regulatory pathway distinct from that described for cytokine-induced NF-kappaB activation and have important implications with regard to both normal glial cell physiology and pathogenesis., In salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland., There were multi-nucleotide in-frame deletion mutations in exon 19 of EGFR gene. Mutations of the exon 19 of EGFR gene were higher in female, non-smoking and adenocarcinoma lung cancer patients., These studies demonstrate positive cross talk between ER, c-Src, EGFR, and STAT5b in ER+ breast cancer cells., There was a statistically significant increase in the proportion of cases with gains of EGFR in squamous cell carcinomas, compared with adenocarcinomas, EGFR was amplified 11% in high-grade dysplasia/esophageal adenocarcinoma cases., EGFR gene mutation was the only significant molecular predictor for time-to-progression in non small cell lung cancer., EGFR FISH-positive status was associated with improved outcome after erlotinib therapy., was no difference in the expression of EGFR, p185(erbB-2) or Bcl-2, or in nuclear accumulation of p53 in these IDC from pre- vs. post-menopausal women., Integrin alphavbeta3 mediates upregulation of EGFR expression and activity in ovarian neoplasms., Hyaluronic acid promotes CD44-EGFR interaction, which in turn activates PKC signaling, involving Akt, Rac1, Phox, and the production of ROS, FAK, and MMP-2, to enhance melanoma cell motility., KRAS mutations are associated with cetuximab failure in EGFR FISH+ colorectal cancer. There is potential prognostic implication of IGF1R expression in colorectal cancer, EGF contributes to differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-receptor activation and is important modulator of wound healing and scar tissue formation., Somatic mutations in the exons 18 to 21 of the tyrosine kinase (TK) domain of EGFR are correlated with a high likelihood of response to EGFR TK inhibitors in advanced lung cancer., Somatic mutations in the EGFR have emerged as important biomarkers in predicting the likelihood of tumor response to the EGFR tyrosine kinase inhibitor gefitinib in patients with advanced NSCLC., Immunoexpression of epidermal growth factor receptor in salivary gland-type lung carcinomas is not related to epidermal growth factor receptor gene copy number or mutational status., We show that the inhibition of CK1 activates RhoB and promotes RhoB dependent actin fiber formation and EGF-R level., selected polymorphic variants in the estrogen biosynthesis and metabolism pathways are unlikely to be major genetic modifiers of the prevalence of EGFR-mutant non-small-cell lung cancer, expression and activation of c-Src as well as EGF receptor promotes head and neck squamous cell carcinoma progression, PLCgamma-1 and c-Src activation contribute to HNSCC invasion downstream of EGF receptor, Cardiomyocyte expression of mutant ErbB-1 leads to the blockade of ErbB-2 signaling and cardiac dysfunction., These data implicate ataxin-2 to play a role in endocytic receptor cycling., EGFR is a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas, Regulation of hERG channels by protein tyrosine kinases modifies the channel activity and thus likely alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons., analysis of PAFR activation and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer, inhibition of HER3 may be more clinically relevant than inhibition of EGFR in HER2-amplified breast cancer and adding pertuzumab to trastuzumab may augment therapeutic benefit by blocking HER2/HER3 signaling, present data clearly show that EGFR status is independent of K-Ras mutations in colorectal tumors, gefitinib has significant cytotoxic activity in AML by inducing apoptosis through non-EGFR dependent pathways., EGFR activation induces COX-2 expression through PI-3K and/or p38MAPK pathways, EGFR and erbB2 are potential targets in treatment of Malignant peripheral nerve sheath tumors, EGFR polymorphisms are associated with significant differences in the in vitro cytotoxicity of several types of DNA-interfering agents, epidermal growth factor receptor mediates allergic airway remodelling, EGFR protein is frequently expressed in a subset of patients with chemorefractory metastatic embryonal carcinoma, Our data suggests that R497K polymorphism of epidermal growth factor receptor gene may be used as a genetic susceptibility marker of acute coronary syndrome, In vascular smooth muscle cells shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation., the mutational spectrum of somatic mutations of EGFR in non-small cell lung cancer (Analytical database), EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail, analysis of EGFR mutations in small samples obtained from patients with non-small cell lung cancer, CSF1, EGFR, and CA IX have roles in increasing survival in early-stage squamous cell carcinoma of the lung, the hMena(+11a) isoform is associated with an epithelial phenotype and identifies EGFR-dependent cell lines that are sensitive to the EGFR inhibitor erlotinib, histone deacetylase inhibition may not only reactivate silenced ER, but also simultaneously deplete EGFR expression, the length of the EGFR CA repeat polymorphism in lung carcinoma is inversely related with level of EGFR protein expression in the carcinoma, These results suggest that PI-sEGFR, a proteolytic isoform of the epidermal growth factor receptor (EGFR), arises by proteolytic cleavage of EGFR via a mechanism that is regulated by both PKC- and phosphorylation-dependent pathways., This is the first comparison of multiple, site-specific phosphoproteins with the EGFR tyrosine kinase domain mutation status in vivo., Report peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo., Clathrin-mediated endocytosis of the EGFR unexpectedly has a greater impact on receptor signaling than on receptor degradation., High levels of EGFR is associated with head and neck squamous cell carcinoma., analysis of EGFR and HER2 expression in primary cervical cancers and corresponding lymph node metastases, 64)Cu-DOTA-cetuximab was successfully used to detect and quantify EGFR expression in cervical cancer tumors, and small-animal PET/CT of EGFR-expressing CaSki tumors suggests potential for PET/CT of EGFR-positive tumors., EGFR expression and genomic gains at the EGFR locus are prevalent in osteosarcoma tumors, which also commonly harbor deletions at the PTEN locus, ADAM8 and EGFR are overexpressed in non-small cell lung cancer., Distinct molecular targets of EGFR1 and EGFRvIII are identified and the importance of receptor internalization in distinguishing their specific functions, is demonstrated., addiction (dependence on a single oncogene) to the mutationally activated EGFR in human lung cancer cells, review of EGFR, its major signaling pathways, its identification and biology in NSCLC and responsiveness to gefitinib, erlotinib and cetuximab in connection to EGFR mutations and mechanisms of resistance to tyrosine kinase inhibitors [review], In human gingival fibroblasts, enamel matrix derivative-induced extracellular regulated kinase activation and proliferation are partially due to a Src-dependent, metalloproteinase-mediated transactivation of epidermal growth factor receptor., WWP1 may promote cell proliferation and survival partially through suppressing RNF11-mediated ErbB2 and EGFR downregulation in human cancer cells., An amino acid substitution in EGFR polymorphism may be associated with favorable prognosis of advanced lung cancers., The dimerization and the slow internalization of the receptor accompanied by the delayed phosphorylation of tyrosine 1068 and its degradation by the proteasome, is reported., Breast cancer cell line subpopulations differed in the amplification of the egfr-locus 7p11-14 showing egfr gene amplification rates of up to 60-fold in high-level expressing populations and less than 2-fold in low-level expressing populations., EGFR gene amplification, protein over-expression and no mutation in tyrosine kinase domain is associated with recurrent glioblastoma., there is a high expression of EGFR and/or c-kit in basal-like breast carcinoma in this series from Uganda and their expression is associated with features of poor prognosis., A worse tumor differentiation and a positive nodal stage were significantly associated with EGFR overexpression, Mena expression in colorectal lesions., cDNA microarray analysis does not indicate any specific target or treatment effects of head and neck squamous cell carcinoma with mutant P53 and over-expressed EGFR., EGFR mutations indicates that they are related to the mechanism of the pathogenesis of lung cancer., EGFR and MAPK phosphorylation is found in chloracne tissues., These data indicate that ERK activity, by phosphorylation of a threonine residue in the EGFR juxtamembrane cytoplasmic domain, modulates EGFR trafficking and signaling., ARAP1 controls the late steps of the endocytic trafficking of the EGF-R, Patients with HER2 nonamplified and HER1 through HER3-negative tumors showed significantly increased relapse-free and overall survival rates when treated with epirubucin-CMF., Recombinant EGFR constructs containing the extracellular, transmembrane, juxtamembrane, and kinase domains are overexpressed and purified from human embryonic kidney 293 cell cultures., EGFR and TLR4 in 16HBE14o- cells stimulated with meprin alpha. NFkappaB was also activated via MyD88 in these cells by meprin alpha, Gene-gene interaction of EGFR 497Arg>Lys and EGF +61A>G polymorphisms enhanced risk for esophageal cancer, indicating additive effects., Bayesian network analysis of these and other datasets revealed that PTRF might be a potentially important component of the ERBB signaling network, Cortactin, fascin-1 and EGFR have roles in progression of ovarian carcinomas, As the upstream of Akt activation, H. pylori infection activated epidermal growth factor receptor (EGFR) at Tyr 992, phosphatidylinositol 3-OH kinase (PI3K) p85 subunit and PI3K-dependent kinase 1 at Ser 241., EGFR autocrine system can couple multiple signaling pathways to ERK activation, multiple mechanisms underlie acquired gefitinib resistance, and selection on a background of EGFR genetic heterogeneity also contributes to acquisition of resistance in a proportion of nonsmall cell lung cancers, EGFRvIII with ErbB-2 enhances tumorigenesis, The combination of EGFR expression and growth pattern is a strong prognostic indicator for improved survival in non-small-cell lung cancer treated with gefitinib., Radiation-induced caveolin-1- and Receptor, Epidermal Growth Factor-phosphorylations were associated with nuclear EGFR transport and activation of DNA-Activated Protein Kinase., smoking status alone appears inappropriate in selecting patients for EGFR-TKI treatment., COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways, EGFR mutations significantly predict both a survival benefit from gefitinib and a favorable prognosis in patients with advanced lung adenocarcinoma, Wounding activates two distinct signaling pathways that induce EGFR activation and promote healing of wounds in epithelial cells., HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells, The median survival time of patients with the EGFR somatic mutation was significantly longer in patients with advanced non-squamous, non-small cell lung cancer, In this study, we show that cell surface EGFRs promote cell growth, whereas intracellular EGF receptors promote cell death., Increased EGFR gene copy number was related to a high SUV(max) on FDG-PET, Activated EGFR is reported as a novel target in pancreatic cancer therapy., lung epithelial cells secrete AMCase via an EGFR-dependent pathway that is activated by ADAM17 and mediates its effects via Ras., EGFR mutations are associated with non-small cell lung cancer., Epidermal growth factor receptor intron-1 polymorphism is associated with gefitinib response in advanced non-small cell lung cancer., Mutations in epidermal growth factor receptor is associated with non-small cell lung cancer., STAT3 constitutive activation, alone and in concurrence with EGFR expression, plays an important role in high-grade/malignant gliomas and targeting STAT3/JAK2 sensitizes these tumors to anti-EGFR and alkylating agents, analysis of epidermal growth factor receptor mutations in small cell lung cancer, IMC-C225 cross-links integrins with EGFR, leading to Vav2-dependent activation of RhoA, The divergent signaling functions of IGF1R and EGFR suggested the potential for synergism by a combination of therapy directed at the two receptors., Somatic mutations in the EGFR have emerged as important biomarkers in predicting the likelihood of tumor response to the EGFR tyrosine kinase inhibitor gefitinib in patients with advanced NSCLC., rhomboid family-1 is critically involved in a G protein-coupled receptors ligand-stimulated process leading to the activation of latent epidermal growth factor receptor ligands, EGFR immunoreactivity significantly correlates with worse prognosis in patients with triple-negative Invasive ductal carcinomas, These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway., Data show that EGFR was expressed more frequently in metastatic and primary tumour tissues as revealed by immunohistochemistry., Our data determine that higher-order EGFR oligomers are the dominant species associated with the ligand activated EGFR tyrosine kinase., ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation, findings are consistent with the hypothesis that EGFR signaling plays an important role in A549 cell physiology and acts synergistically with claudin-2 to accelerate tumor colonizati, the role of transcriptional regulation of conserved dinucleotide repeats in intron 1 of the EGFR gene might be conserved in other ErbB genes., Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells., no association of the two promoter EGFR polymorphisms (or combinations of these polymorphisms) and risk of astrocytomas, EGFR expression or survival was found in a Brazilian population, EGFR and BRCA1 might be candidate therapeutic targets in triple-negative breast cancer, Associatiion of EGFR gene mutations with EGFR amplification in advanced non-small cell lung neoplasms is reported., Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation., The novel coupling of antiviral defense machinery (i.e., TLR3) and major epithelial proliferation/repair pathway (i.e., EGFR) might play an important role in viral-induced airway remodeling and airway disease exacerbation., EGFR mutations are associated with non-small cell lung cancer., EGFR overexpression occurred independently of histological type and clinical parameters in salivary gland carcinomas, EGFR as well as HER2 are prognostic factors of worse clinical outcomes, in high-risk early breast cancer, EGFR mutations may be a valuable prognostic factor for disease free survival of surgically treated lung adenocarcinoma patients independently from adjuvant chemotherapy, The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of th EGFR-ERK1/2 signalling pathway., Results show that epidermal growth factor receptor inhibition stabilizes desmoglein 2 at intercellular junctions by interfering with its accumulation in an internalized cytoplasmic pool., mutations in exons 19 or 21 are considered to be a good predictor of the efficacy of gefitinib therapy for non-small cell lung cancer, [CA]n genotype appears to be a useful predictive marker of the development of skin rashes with gefitinib treatment, Epidermal growth factor receptor mutations are associated with optimal resectability in malignant peritoneal mesothelioma., EGFR mutations not only increase receptor activity, but also alter responses of downstream signaling cascades in human non-small cell lung cancer cell lines., JAK2, EGFR and PI3KCA hot spot mutations are uncommon in endocrine tumors, Doublets in the EGFR and TP53 genes in human lung cancer are elevated about eight- and three-fold, respectively, relative to spontaneous doublets in mouse (6% and 2.3% versus 0.7%)., acquired resistance to ATP-mimetic EGFR kinase inhibitors may often be associated with amino acid substitutions that alter drug contact residues in the EGFR ATP-binding pocket, EGFR took part in development and progression of colorectal carcinomas and that Id-1 was associated with regulations of EGFR, Pre-formed EGFR dimers are critical to the initial EGF binding and the extent of the pre-formed dimers is not affected by receptor density., EGFR may represent a molecular marker predictive for poor response to preoperative chemoradiotherapy in locally advanced gastric carcinoma., Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III is reported., H. pylori blocks EGFR endocytosis and receptor degradation upon prolonged infection of gastric epithelial cells., Growth and molecular interactions of the anti-EGFR antibody cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells, the AC/cAMP/Epac signaling pathway in ovary may mediate the up-regulation of EGFR by gonadotropins via ERK1/2 and Akt activation, genetic polymorphism is associated with a significantly increased risk of female lung adenocarcinoma, Human eccrine sweat glands express CK7, CK8, CK14, CK18, CK19, CEA, EMA, Ki67, p63, EGF and EGFR. In skin, CEA can be used as a specific immunological marker of sweat glands., HER2 affects glial-cell migration by modulating EGFR-HER2 signal transduction, and that this effect is mediated by N-cadherin., Overexpression of EGFR is a significant predictor of clinical response to fluoropyrimidines in colorectal cancer., EGFR-targeted gelatin-based engineered nanocarrier systems show tremendous promise an effective gene delivery vector with the potential to treat pancreatic cancer., Progenitor sphere formation requires signaling from the EGFR tyrosine kinase. Nf1 loss of function amplifies this progenitor pool, which becomes hypersensitive to growth factors and confers tumorigenesis., Polymorphisms in COX-2 and EGFR may be useful independent molecular markers to predict clinical outcome in patients with mCRC treated with single-agent cetuximab, EGFR-related markers, pERK, pSTAT3, E-cadherin, pCMET and mutations in KRAS were associated with survival of NSCLB patients., posttranslationally regulated by reversible S-nitrosylation in neuroblastioma cell line, high gene copy number might be associated with shorter survival in patients with non-small-cell lung cancer in Japan, increase in both gene expression and gene copy number in Chinese patients with gastric carcinoma; likely due to chromosome 7 polysomy, Taken together, these data provide direct evidence of the dependence of IFNgamma-induced EGFR transactivation upon EFDR receptor expression level in epithelial cells., Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression in human airway epithelial cells., We confirmed the partial responsibility of p-Akt activation in invasion of some bladder cancer cell lines expressing N-cadherin or p-EGFR, To the best of our knowledge, this is the first report describing crosstalk/interactions between SSTRs and ErbBs., The expression of EGFR and LRP could be used to predict chemotherapy resistance and prognosis of ovarian cancer., Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas., Results revealed significantly increased levels of epidermal growth factor in both serum and bronco-alveolar lavage., epidermal growth factor receptor-mutation has a positive non-small cell lung cancer response to Erlotinib combined with cyclosporine in a liver-transplant recipient., Germ-line and somatic mutations of the EGFR T790M is associated with lung cancer., EGFR overexpression represent important alterations that are related to the molecular pathways underpinning colorectal carcinogenesis, EGFR gene expression in pancreatic adenocarcinoma cells significantly surpassed that in normal pancreatic cells., MET amplification is present in untreated NSCLC and EGFR mutation or MET amplification activates MET protein in NSCLC, In contrast to trastuzumab sensitive breast cancer cells, combinatorial targeting of ERBB receptors or of key signaling intermediates does not have potential for treatment of de novo trastuzumab resistant cells., GM3-mediated inhibition of EGFR phosphorylation is caused by interaction of GM3 with GlcNAc-terminated N-glycan on EGFR., Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation., The association of EGFR mutation status with patient characteristics and the SUV(MAX) from the [(18)F]FDG PET was evaluated, Phosphorylation of EGFR at Tyr992 may play some specific functional role in esophageal carcinomas besides promotion of cell proliferation , probably dysregulation of the downstream signal transduction pathways., p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047., In EGFR-mutant adenocarcinoma metastases, the higher levels of EGFR overexpression and more homogeneously distributed high gene copy numbers suggest tumor progression., Epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells., These results highlight the prognostic value of CDK4 amplification and of simultaneous EGFR-p53 alterations in the clinical outcome of patients with primary GBM., The switch in EGFR ligand availability as advanced prostate cancer progresses affects cell survival and contributes to bone remodeling., the interplay between Nedd4-2-related E3 ligases that regulate ACK1 levels and Cbl that modifies EGF receptor impinges on cell receptor dynamics., EGFR gene numerical alterations -although rare- and also chromosome 7 aneuploidy maybe affect prognosis in hepatocellular carcinomas, Erlotinib and gefitinib inhibited EGFR and ERK1/2 phosphorylation/activation in all GBMs, irrespective of the antiproliferative response observed., analysis of distinct EGFR mutations in non-small cell lung cancer, EGFR expression may represent an adverse prognostic marker in patients with triple-negative breast cancer, Our findings have confirmed a key role of EGFR in determining the proliferative and malignant potential of laryngeal carcinoma, Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer., High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients., EGFR is a determinant of basaloid breast cancer., The expression of EGFR, Ki67, p16 in middle ear cholesteatoma was significantly higher compared with controls., Depletion of SCAMP3 in HeLa cells by inhibitory RNA accelerated degradation of EGFR and EGF while inhibiting recycling, COX-2, EGFR and VEGF are overexpressed in gastric carcinoma. Helicobacter pylori infection may upregulate the expression of COX-2 and EGFR in gastric cancer tissues., EGFR mutations in the tyrosine kinase domain is a rare event in salivary gland carcinomas., EGFR signals to mTOR through PKC and independently of Akt in glioma, (1)R-epidermal growth factor receptor crosstalk may be a key interaction that maintains tumor growth, associated with non-small lung cancer, Mutation in EGFR is associated with adrenocortical carcinomas., No evidence for an apparent association of common genetic polymorphisms in EGFR with breast cancer risk., BRCA1-mutant mammary epithelials prdispos to the developmnt os estrogen receptor negative, EGFR positive breast cancers., findings provide critical insights into the role of mutant EGFR signaling function in glioblastoma multiforme tumor biology, polymorphisms in EGFR are potential predictors for clinical outcome in advanced NSCLC patients treated with Gefitinib, Bacterial products (e.g., LPS) triggers a positive feedback loop involving COX-2/PGE(2) in biliary carcinoma cells and this second phase of EGFR phosphorylation is implicated in cell invasion by LPS, Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells., Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma., results suggest that clusterin requires EGFR activation to deliver its mitogenic signal through the Ras/Raf-1/MEK/ERK signaling cascade in astrocytes, Patients with advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations show response to gefitinib., These results suggest that one mechanism of the apoptotic activity of magnolol involves its effect on epidermal growth factor receptor-mediated EGFR/PI3K/Akt signaling transduction pathways., Microvesicles produced by human cancer cells harboring activated EGFR (A431, A549, DLD-1) can be taken up by cultured endothelial cells, in which they elicit EGFR-dependent responses, including activation of MAPK and Akt pathways., Phosphorylated EGFR appears to be a better indicator for lower disease-free survival than EGFR overexpression itself in localized non-small cell lung cancer., mutations in EGFR and copy number gains in EGFR and HER2 were independent factors related to gefitinib sensitivity, in descending order of importance, T790M-EGFR mutation is associated with relapses in lung cancer., Substantial discordance in EGFR and K-RAS mutational status between the primary tumours and corresponding metastases in patients with non-small-cell lung cancer., For urine cytology, immunostaining method with epidermal growth factor receptor and p53 was useful for the differential diagnosis., EGFR activation by H pylori infection has an antiapoptotic effect in gastric epithelial cells that appears to involve Akt signaling and Bcl family members., a high frequency of the EGFR-activating mutations in papillary thyroid carcinoma (PTC) suggests that the EGFR mutation may be an important event in the development of PTC., phosphorylation and activation of GSTP1 by EGFR as a novel, heretofore unrecognized component of the EGFR signaling network, EGFR gene gain does not impact survival after resection in non-small-cell lung cancer., mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin is able to disrupt epidermal homeostasis and identify, Low EGFR expression might be a predictive marker for relapse in curative resected stage III-IV (M0) gastric cancer patients who received adjuvant FP chemotherapy., R497K polymorphism of Epidermal growth factor receptor gene may be associated with DCM in a Chinese population., overexpression of EGFR is associated with thymic carcinoma., ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR to attenuate the EGF-induced cell migration., EGFR mutations were never found in tumors with KRAS mutations, suggesting a mutually exclusive relationship., ephrinA5 acted as a tumor suppressor in glioma, and its negative regulation of EGFR contributed to the suppressive effects., EGFR staining was seen in the majority of uterine serous carcinoma patients, The thyroid tumor was focally positive for EGFR (immunostaining) and two point mutations were identified, one on exon 18 and one on exon 20 in the tyrosine kinase (TK) domain., EGFR expression and KRAS mutation status is predictive for clinical response to matuzumab +/- paclitaxel in patients with advanced NSCLC., EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens., Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab in Non-Small-Cell Lung neoplasms, 3 of 11 cases (27.3%) were positive for EGFR, missense mutations were observed in 18 of 161 glioblastoma cases; 4 novel mutations were detected; mutations of the EGFR extracellular domain were not associated with overall survival or age at onset, but were significantly associated with gender, ErbB-1/-2 receptors are inhibited by lapatinib in bladder neoplasms, We confirm EMP-1 is abnormally expressed in intractable epilepsy and suggest the interaction of EGFR and EMP-1 plays a role in the mechanism of drug resistance in epilepsy, A subset of nonmucinous adenocarcinomas, not necessarily of the bronchioloalveolar type, is related to EGFR mutations, HER1 and 2 do not seem to have a role in endometriosis physiopathology., Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells is characterized by multiplex kinase activity profiling, Mathematical modeling was used to investigate the relationship between EGF internalization kinetics, EGFR expression, and internalization machinery., mutant EGFR-Src interaction and cooperativity play critical roles in constitutive engagement of the downstream signaling pathways that allow NSCLC-associated EGFR mutants to mediate oncogenesis., Lack of association between common polymorphisms of epidermal growth factor receptors and nonsyndromic cleft lip with or without cleft palate., There was a statistically significant correlation between EGFR expression and histological grade. Stage classification was the only parameter in multivariate analysis that was an independent predictor of low overall and disease-free survival., Inhibition of both AR isoforms did not affect EGFR and ERBB2 transcript levels but decreased EGFR and increased ERBB2 protein levels. Proliferation of 22Rv1 cells in SDM was inhibited in the absence of AR and ARDeltaCTD., The authors show that virus infection results in the profound upregulation of Wilms' Tumour 1 (WT1) protein, a transcription factor associated with the negative regulation of a number of growth factors and growth factor receptors, including EGFR., Diesel particle-induced transcriptional expression of p21 involves activation of EGFR, Src, and Stat3, exploiting the smaller heavy chain antibodies of camels against EGFRvIII seems promising in the diagnosis procedures of thyroid neoplasms., Study shows that genomic instability due to Myc amplification may cause specific amplification of EGFR and/or ERBB2 in gallbladder adenocarcinoma., The suppression of VEGF expression by Ganoderma tsugae methanol extract can be restored by treatment with EGF suggesting that GTME inhibits VEGF expression via the suppression of EGFR expression., EGFR was found to be overexpressed in all oral tongue squamous cell carcinomas making this cancer type interesting for exploring new therapeutic agents targeting the EGFR receptor., Absence of mutations in the epidermal growth factor receptor (EGFR) kinase domain in patients with mesothelioma., The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding., The mechanism of aldosterone related mesangial cell proliferation was studied, revealing the role of EGF receptor transactivation through a redox-sensitive process., Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30., Enediyne lidamycin enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib, in epidermoid carcinoma A431 cells and lung carcinoma H460 cells., Cytologic specimens were more likely to have an epidermal growth factor receptor mutation than surgical specimens, Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells., Results describe the expression pattern of p53, BCL-2 and epidermal growth factor receptor proteins in the hydatidiform moles., Data show that the AP-2 complex is involved in the internalization of activated epidermal growth factor receptor from the cell surface., In patients with non-small cell lung cancer, there is a higher frequency of epithelial markers in patients with EGFR mutation., We performed EGFR mutation analysis in 307 NSCLC (exon 18-21). The data were analyzed for associations with clinical-pathological parameters., EGFR protein overexpression and its tyrosine kinase domain mutations in areca quid-associated oral cavity squamous cell carcinoma, The EGFR-mutated lung adenocarcinoma showed a significantly higher prevalence of past illness involving the gastric cancer in males or uterine myoma in females, confluent p38alpha-deficient cells fail to downregulate Spry2, providing them in turn with sustained EGFR signaling that facilitates cell overgrowth and oncogenic transformation, These findings suggest that ouabain downregulates mCD14 expression on monocytes through EGFR transactivation and p38 MAPK activation., EGFR mutations is associated with non-small-cell lung cancer., K-ras, EGFR, and BRAF mutations are disproportionately seen in adenocarcinomas of lung with a dominant micropapillary growth pattern compared with conventional adenocarcinoma in our institutional experience., Our findings suggest modified bladder cancer risk and survival associated with genetic variation in the EGFR pathway., Elevated EGFR is associated with less favorable disease outcome in ovarian cancer., EGFR/KRAS mutation testing of multiple lung adenocarcinomas can assist in differentiating multiple primary lung adenocarcinomas from metastatic lesions., Combination of MET and EGFR inhibitors triggered stronger inhibition on cell proliferation and invasion of MPM cells than that of each in vitro., EGFR T790M mutation and c-MET amplification can occur in tyrosine kinase inhibitor-resistant non-small cell lung cancer with wild-type EGFR. These genetic defects might be related to different survival outcome., EGFR gene amplification seems to be restricted to high-grade tumors, WHO grade IV astrocytomas, and grade III oligodendroglial tumors., Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM9/10-mediated mechanism., EGFR, NFkappaB, and STAT3 are required for human iNOS gene induction in proximal tubule cells in response to pressure or EGF, indicating a similar mechanism of activation., EGFR mutation is associated with metastatic in non-small cell lung cancer., Immunohistochemical expression of EGFR is variable between laboratories, even using standardised protocols, EGFR mutation up-regulates EGR1 expression through the ERK pathway., Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer., examined the effect of EGFR mutations and BRCA1 mRNA levels on outcome in advanced non-small-cell lung cancer, UV irradiation stimulates rapid EGFR nuclear translocation, which is dependent on phosphorylation of specific EGFR tyrosine residues., miR-206 contributes to EGFR-mediated abrogation of estrogenic responses in MCF-7 cells, contributes to a Luminal-A- to Basal-like phenotypic switch, and may be a measure of EGFR response within Basal-like breast tumors, Expression of EGFRvIII in laryngeal carcinoma was confirmed in this study. It is tumor-specific and tends to be more frequent in EGFR-over expressing tumor tissues and poorly differentiated ones, which may in part contribute to the malignant phenotype., The activation of SHP-2 phosphorylation at Tyr542 in glioblastoma cell lines results in increased PTPase activity and distinct mechanisms of cell cycle progression and SHP-2. Its PTPase activity plays a critical role in EGFRvIII-mediated transformation., Fibrinogen binding to ICAM-1 promotes mucin production by decreasing TGF-alpha-induced EGFR and ERK1/2 activation., targeting the EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization, EGFR expression by tumor cells of the breast cancer defines a specific subset of tumors with poor prognosis and potential resistance to the adjuvant therapy., Results show that inhibition of angiogenesis by gefitinib seems independent on the EGFR genetic status of the tumors., Results showed that 45.8% of typical carcinoid and 28.6% of atypical carcinoid tumors express EGFR, 100% of the tumors lack expression of ErbB2, and 100% have moderate to intense staining for ErbB3 and ErbB4., High epidermal growth factor receptor expression is associated with metastatic colorectal cancer lymph nodes., Study concludes that endosomal localization of Lst2, along with an ability to divert incoming EGFR molecules to degradation in lysosomes, is regulated by ubiquitinylation/deubiquitinylation cycles., EGFR expression is different between primary nasopharygeal carcinoma and lymph node metastases., EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics., Stage IV NSCLC patients with mutated EGFR had a longer progression-free survival after the front-line chemotherapy., intestinal epithelial cancer cells commonly display an EGFR-mediated sustained activation of Src under anoikis conditions, the results indicated that EGFR overexpression and histologic subtyping by predominant tumor cell type in mucin pools may be helpful for predicting clinical outcome in patients with MGC., Caveolin-1 overexpression in MCF-7 breast cancer cell line modulates EGFR activation levels and EGF-induced EGFR signalling., Theaflavins decreased the level of EGFR and inhibited the activation of EGFR, and attenuated airway mucous hypersecretion via the ERK pathway., A considerable proportion of NSCLC showed discrepancy in EGFR mutations between primary tumors and metastatic lymph nodes, suggesting tumor heterogeneity at the molecular level during the process of metastasis., findings show that EGFR and ErbB2 can negatively regulate androgen receptor (AR) mRNA and may provide an approach to suppress AR expression in CRPC, high HER2 and EGF protein levels were significantly correlated with TOB1 expression in breast cancer, whereas EGFR and EGF levels correlated with TOB1 phosphorylation, Beta-arrestin is required for the maintenance of a beta1-Adrenergic receptor -epidermal growth factor receptor interaction that can direct cytosolic targeting of extracellular regulated kinase in response to catecholamine stimulation., Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization., Activating mutations within the EGFR TK domain can be used to predict the risk of recurrence in curatively resected pulmonary adenocarcinoma., Results show that DUSP4 is involved in negative feedback control of EGFR signaling, and provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma., lapatinib inhibits the nuclear translocation of EGFR and HER2 and downregulates TS, thus sensitizing cancer cells to fluoropyrimidine, EGFR mutations are associated with good response to gefitinib therapy., Results compare the effect of six different ligands on endocytic trafficking of epidermal growth factor receptors and show that they have very diverse effects on endocytic sorting., These results suggest that coordinated phosphorylation of EGFR involving sites Tyr(998), Ser(991), Ser(1039), and Thr(1041) governs the trafficking of EGF receptors., Gefitinib monotherapy confers substantial clinical benefit in terms of progression-free survival and overall survival in non-small cell lung cancer patients with EGFR mutations., EGF is expressed and produced by annulus cells in vivo and in 3D culture, The expression of EGFR in ovarian cancer is related to angiogenesis and chemoresistance, There was no statistically significant association between epidermal growth factor receptor mutations and the clinical characteristics., Enhanced multipotent stromal cells osteogenic differentiation corresponds to a sustained combination of receptor expression and ligand presentation, both of which are maintained by tethered epidermal growth factor., Data show that Dsg1 is required for maintaining epidermal tissue integrity in superficial layers, supports keratinocyte differentiation and suprabasal morphogenesis, and is required for suppression of epidermal growth factor receptor signaling., Elortinib seems to be site specific for intracranial metases harboring EGFR exon 19 deletions., CCHCR1 is up-regulated in skin cancer and associated with EGFR expression, The production of MUC5AC in human nasal epithelial cells is regulated via the expression and activation of epidermal growth factor receptor signaling pathway., Tetraspanins are co-immunoprecipitated with EGFR in both A431 and KB cells, indicating that TSPs are closely associated with EGFR., analysis of the experssion of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma, Study shows that the intracellular juxtamembrane segment of the EGF receptor, known to potentiate kinase activity, is able to dimerize the kinase domains., irradiation-induced activation of EGFR upregulates Pim-1, Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature., Results suggest that the mutations of EGFR, KRAS, BRAF between primary tumors and corresponding lymph node metastases should be considered whenever mutations are used for the selection of patients for EGFR-directed tyrosine kinase inhibitor therapy., Findings suggest that in microsatellite instability-positive tumors current therapies targeting EGFR overexpression may have either no effect or an opposite to the expected effect., EGFR mutations possess statistical significance for a better therapy response and longer survival in all patients with adenocarcinomas (smokers as well as non-smokers)., These results suggest that aberrantly increased expression of miR-21, which is enhanced further by the activated EGFR signaling pathway, plays a significant role in lung carcinogenesis in never-smokers, as well as in smokers., PML was found to be important for E1A-induced suppression of EGFR and subsequent killing of head and neck squamous cell carcinoma cells suggesting a novel pathway involving PML and p73 in the regulation of EGFR expression., Haploinsufficiency of the tumor suppressor ANXA7 due to monosomy of chromosome 10 provides a clinically relevant mechanism to augment EGFR signaling in glioblastomas beyond that resulting from amplification of the EGFR gene., EGFR signalling is involved in Snail protein overexpression, EGFR mutation analysis for 1,176 NSCLC patients showed mutation was significantly associated with adenocarcinoma & light-smoking, but not gender. Exon 19 deletions were more frequent in males while exon 21 deletions were more frequent in females., Our results underscore the divergent mechanisms underlying the tumorigenesis of periocular and extraocular sebaceous carcinoma and suggest an association between aggressive behavior and increased EGFR expression in extraocular sebaceous carcinoma., Pathogenic L1-CAM mutations reduce the activation of EGFR., In MDA-MB-231 breast cancer cells, GRP-R and EGF-R synergize to regulate cell migration and IL-8 expression, but not cell proliferation., Studied assoc'n of EGFR & ESR1 SNPs with breast cancer risk/prog. in Tunisian patients. No evidence found for assoc'n between EGFR R521K polymorphism and breast cancer risk,but homozygous GG(Arg)genotype more prevalent in patients w/lymph node metastasis., Four genes, PCSK1, (P=0.008), EGFR,(P=0.003), PAX4,(P=0.008), and LYN,(P=0.002) consistently yielded statistical evidence for association with longevity., ZIP is a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis, Report EGFR-dependent and independent activation of Akt/mTOR/p70S6 kinase/4E-BP1 cascade in bone and soft tissue tumors., the smoking dose predicted EGFR mutations with a moderate diagnostic accuracy in patients with non-small-cell lung cancer., The combined measurement of PTEN and MMP9 transcripts might represent a novel reliable tool for the differential diagnosis of high-grade gliomas., Data show that compared with the EGFR mutant and WT/WT cohorts, patients with EML4-ALK mutant tumors were significantly younger and were more likely to be men., High epidermal growth factor receptor expression is associated with second primary tumors of the upper aero-digestive tract., EGFR copy number changes could supplement the clinical significance of EGFR as a marker related to its pathogenesis and targeted therapy., Most cases os synovial sarcoma showed overexpression of EGFR protein, but it was not accompanied by gene amplification., The relationship between COX-2 and EGFR in cancer cells, was investigted., Patients harboring sensitizing EGFR mutations should be considered for first-line erlotinib or gefitinib., study confirmed an increase in EGFR protein expression and gene amplification with the increase in biological aggressiveness of glottic lesions, EGFR protein overexpression and increased EGFR gene copy number is associated with sarcomatoid carcinomas of the lung., Downregulation of EGFR is associated with non-small cell lung cancer metastasis., a mechanism linking EGFR signaling with Fyn and Src activation to promote glioblastoma progression and invasion in vivo, novel cross talk occurs between tumor necrosis factor receptor and TGF-alpha/epidermal growth factor receptor in stimulating human bone marrow mesenchymal stem cell hepatocyte growth factor production, Both antiestrogen sensitive and antiestrogen resistant breast cancer cells showed the ability to switch between ERalpha and ErbB signaling depending on the applied treatment, thus supporting combined therapy targeting both receptor systems., examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis, Estrogen receptor alpha and beta expression distinguishes a subset of NSCLC that has defined clinicopathologic and genetic features. In lung adenocarcinoma, estrogen receptor alpha expression correlates with EGFR mutations., Report negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells., CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells., EGFR, c-Met, and VEGFR1 involved in carcinogenesis are well-represented and coexpressed in anal cancers, especially in HIV-positive population, Studies show that the intrinsic molecular signature of five markers, ER, PR, HER-2, CK 5/6, and EGFR, demonstrated specificity of 100% and sensitivity of 75%, compared with classification by gene expression profiling., Data indicate overexpression of EGFR in A431 cells and low expression in SW962 cells., suppression of Rab5A or 5B hampered the degradation of EGFR, Epidermal growth factor receptor mutations were more frequently observed in females, in non-smokers, and in the presence of bronchioloalveolar features in 411 lung adenocarcinomas ., Elevated CD133, but not VEGF or EGFR, may be a predictive marker of distant recurrence and poor survival after preoperative chemoradiotherapy in rectal cancer, Phosphorylated EGFR without mutations may be a marker of poor prognosis in patients with head and neck squamous cell carcinoma, Data showed that 9 tumor samples had strong expression of P-Akt and 5/9 had P-MAPK, and none of them had EGFR expression., These findings show that non-transformed and transformed prostate epithelial cells may employ different mechanisms to activate EGFR ligands and thereby utilize the EGFR axis to promote cellular proliferation, data identify an elevated frequency of EGFR gene amplification and EGFRvIII mutation in pediatric high-grade glioma than previously recognized, EGFR and KRAS status of primary lung carcinomas may not predict the status in the corresponding metastases., EGFR expression in RCC was mostly located in the cell membrane, whereas the EGFR expression in normal renal tissues was chiefly seen in cytoplasm. Different locations of EGFR expression may be associated with human renal tumorigenesis., TGFbeta(1) activates EGFR via an H(2)O(2)-dependent mechanism, which subsequently leads to the activation of Erk(1/2)., temporal regulation of EGFR endocytosis is achieved by auto-regulatory PLD1 which senses the receptor activation and triggers the translocation of AP2 near to the activated receptor, EGF receptor activation drives cellular processes linked to ovarian tumor development, tumor cell survival, and metastasis. Review., The c.2235-2249 (pGlu746-Ala750del) mutation in exon 19 was found in 2 patients with lung adenocarcinoma. 26% of the NSCLC cases overexpression EGFR had reduced PTEN and increased Mcl-1 expression., These findings support the proposal that nuclear EGFR and cytoskeleton integrity play an important role in breast cancer., EGFR tyrosine kinase domain mutations were not found in medullary thyroid carcinomas. EGFR polysomy & strong expression were seen in 15 & 13% of the tumors respectively. It was overexpressed in metastases., EGFR is expressed in bilary tract cancer, Overexpression of the EGFR gene in many Wilms tumor cases warrants further study to determine the therapeutic benefit of EGFR inhibitors in combination with other therapies in Wilms tumor patients., African American patients with non-small-cell lung cancer are significantly less likely than white counterparts to harbor activating mutations of EGFR., AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation-induced cell death., HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress, Cell lines with EGFR 3'-UTR mutations were more sensitive to EGFR inhibition than EGFR 3'-UTR WT cells, suggesting that this mutation provides a growth advantage to this subset of MSI colon tumors., These findings confirmed the importance of EGFR immunoexpression rate as well as IL-6 and TNFalpha secretion by peripheral blood mononuclear cells as potential biomarkers for assessing the aggressive tumor phenotype in laryngeal carcinoma., Data show that decorin specifically inhibits EGFR and AR phosphorylation and cross talk between these pathways in prostate cancer cells., Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor., Data suggest that EGFR may be involved in a switch from stem to transient amplifying cell fate., These results propose a novel regulatory mechanism for the abnormal expression of Aurora-A in EGFR-overexpressed cancers., show that EFEMP1 binds EGF receptor (EGFR) in a competitive manner relative to epidermal growth factor (EGF), implicating that EFEMP1 and EGF share the same or adjacent binding sites on the EGFR., The T790M EGFR mutation was found by pyrosequencing, and this seemed to be the cause of drug resistance. Resistant cells also showed MET activation, although gene amplification was not detected., genetic activation of EGFR by mutation or amplification is in a small subset of cutaneous squamous cell carcinoma, Using lung adenocarcinoma samples and cell lines derived from lung adenocarcinomas, we demonstrated that the gene copy number for MET in lung adenocarcinoma tissue samples was increased over EGFR, HGF, and PXN and that it correlated with better prognosis, EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway., Expression of epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues, Taken together, we provide evidence that AREG stimulation of EGFR results in high levels of PTHrP gene expression, contributing to cancer-associated bone pathology., EGFR amplification and exon 19 deletion mutations are associated with lung adenocarcinomas., These results provide a plausible mechanism for EGFRvIII-mediated invasion and establish a functional link between EGFRvIII and CXCR4 signaling pathways., CoxII can be phosphorylated by EGFR and c-Src, and EGF stimulation reduces Cox activity and cellular ATP, an event that is dependent in large part on EGFR localized to the mitochondria., two novel and important functions of CX3CL1 on primary human vascular smooth muscle, Aberrant methylation and alterations of EGFR signaling is associated with chronic obstructive pulmonary disease-related non-small cell lung cancer., Epidermal growth factor receptor mutation is associated with pathologic-radiologic correlation between multiple lung nodules with ground-glass opacity differentiates multicentric origin from intrapulmonary spread., EGFR and KRAS mutations were found in 33 (10%) and 78 (23%) of lung adenocarcinomas, respectively, whereas 226 (67%) cases were negative for both mutations, Studies indicate that capsaicin is a novel modulator of the EGFR/HER-2 pathway in both ER-positive and -negative breast cancer cells with a potential role in the treatment and prevention of human breast cancer., Cytological specimens are equally well suited for EGFR gene analyses and FISH analysis as histological specimens. At present, the value of EGFR-FISH analysis is limited by the lack of validated criteria for FISH positivity., EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance, SNP HER2 I655V, but not the EGFR R497K, was associated with thyroid cancer risk., A novel mechanism for promoting cancer progression by alcohol is found by stimulating the epithelial-mesenchymal transition program in cancer cells via an epidermal growth factor receptor-Snai1 pathway., In analyzing exons 18-21 of EGFR in 96 patients with SCCHN, only one SNP was found in the 78th site of exon 20 and it mostly existed in specimens coming from the hypopharynx., These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways., EGFR mutations are associated with lung adenocarcinomas., Observed weak transactivation is uni-directional where stimulation of EGFR leads to HER3 activation whereas HER3 stimulation does not activate the EGFR., The study demonstrates a novel role of TK in skin wound healing uncovering new signaling pathway mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation., Notch3 not only has a crucial role in lung cancer through regulating apoptosis, but also cooperates with the EGFR-MAPK pathway in modulating Bim., BRAF status, EGFR amplification, and cytoplasmic expression of PTEN were associated with outcome measures in KRAS wild-type patients treated with a cetuximab-based regimen., EGFR mutational status was associated with clinical response in non-small cell lung cancer., The majority of chordomas express EGFR immunohistochemically but only about one-forth show alterations of the EGFR gene., the EGFR pathway is critical for the upregulation of keratinocyte GM-CSF expression under conditions of cytokine stimulation, Data show that the activities of EGFR-MAPK signal pathway were inhibited significantly by overexpression of cav1., Erlotinib therapy for pretreated patients with EGFR-wt tumors seems to have a modest activity with no irreversible toxicity., loss of CRMP1 contribute to the increased invasive phenotype of human Glioblastoma multiforme brain tumors expressing mutant EGFRvIII., Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor., This data suggests the important role of GPR30/EGFR receptor signaling in the development of tamoxifen resistance, Elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer., EGFR may have a role in progression of cervical cancer, Discovery of EGFR, the EGFR signal transduction pathway and mutations of the EGFR gene in lung cancers and glioblastomas. Review., Expression of p27 was positively correlated with the expression of EGFR and GST-pi, while the expression of EGFR was significantly associated with the expression of p21, Autophagy promoted via troglitazone is correlated with AMPKalpha activation and independent of PPARgamma activation and EGFR transactivation., The methods by which HER dimerization can be explored and the potential that this has in the treatment of breast cancer, is reviewed., The synergism deriving from EGFR and ErbB-2 blockade is mediated by alterations in signal transduction and in the expression of cell cycle regulatory proteins, including transcriptional and posttranscriptional regulation of p27(kip1) expression., EGFR and NF-KB expression was negatively correlated with radiosensitivity in human nasopharyngeal carcinoma., study shows that mutant EGFRs in NSCLC cell lines are constitutively endocytosed as shown by their colocalization with the early/recycling endosomal marker transferrin and the late endosomal/lysosomal marker LAMP1., Adhesion-induced EphA2 expression is dependent upon activation of the epidermal growth factor receptor (EGFR), mitogen activated protein kinase kinase (MEK) and Src family kinases (SRC)., The expression of EGFR was correlated with stage, lymph node metastasis, histological grade and relapse of laryngeal cancer., EGFR mutations do not appear to be a common event in upper aerodigestive tract carcinogenesis in this population, analysis of the effect of inhibitors (the chimeric 225 antibody and tyrosine phosphorylation inhibitor AG1478) on the nanoscale clustering of EGFR in HeLa cells, Based on extended survival time under severe conditions, we propose that positive EGFR double-activating somatic mutation may be a good prognostic factor, plasma membrane distribution of the P2Y(2)R is transregulated by the epidermal growth factor receptor, glutamate signaling mediated by AMPA receptor induces U-87MG human malignant glioblastoma cell line proliferation via EGFR-phospho-Akt pathway., Collagen-embedded HA (eHA) inhibits EGFR activation, filopodia formation and cell spreading on a collagen matrix., epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer is associated with dramatic response to low-dose erlotinib., combing activating KRAS mutants and EGFR could help to identify the subgroup of patients who are most likely to respond to cetuximab plus chemotherapy, EGFR plays an essential role in the immunopathobiology of HCMV by mediating viral entry into monocytes and stimulating the aberrant biological activity that promotes hematogenous dissemination., Molecular studies showed 3 (20%) of 15 oncocytic adenocarcinomas of lung with EGFR mutations and 3 additional cases with KRAS mutations., A relationship between high levels of EGFR and HER-2 in the tumors of patients with esophageal squamous-cell carcinoma and intravascular tumor invasion and poor outcome of the disease was detected., Our study revealed an influence of the EGFR-R521K genotype on skin toxicity and suggested its relation to clinical activity of cetuximab/docetaxel treatment., Studies indicate that lapatinib - a tyrosine kinase inhibitor targets not only EGFR (erb B1) but also erb B2 (HER2) receptor tyrosine kinase signalling., Matrix-assisted laser desorption ionization remains a potent and highly clinically significant predictor of survival after first-line treatment with erlotinib in non-small-cell lung cancer patients with wild-type EGFR mutation., Results suggest that the EGFR SNP at codon 787 of exon 20 determined in pretreatment biopsy specimens may be a clinically useful biomarker for predicting the prognosis of ESCC patients., Studies indicate communication between tumor cells and their microenvironment is through polypeptide growth factors EGF, FGF, PDGF and receptors for these growth factors., Overexpressions of c-Cbl, Cbl-b, and EGFR are closely related to the invasion and progression of gastric carcinoma., EGFR mutation combined with HER2/3 expression is a significant predictor for gefitinib efficacy on Chinese patients with advanced non-small cell lung cancer., Ligand-independent but p38-dependent EGFR internalization process is involved in the control of keratinocyte physiology during stress conditions., EGFR is moderately or strongly overexpressed on the cell membrane most adenocarcinomas of the biliary tree and has an adverse impact on prognosis. Gain of EGFR gene copy number is present in approximately half of cases., The expression of EGFR increased after each surgical procedure. However it was lower after CO(2) pneumoperitoneum than after laparotomy., Decrease in extracellular domains of EGFR after surgery is associated with breast cancer progression., Antisense-miR-21-treated human gliobalstoma cells showed a decreased expression of EGFR(epidermal growth factor receptor), Mutant dimers showed less stability than wild type EGFR dimer., EGFR is preferentially expressed by human bulge cells, compared to differentiated hair follicle keratinocytes, Primary glioblastomas with and without EGFR amplification did not show any significant differences in average survival, slow physical deformation of the lateral intercellular space in response to a step increase in loading leads to synchronous activation of the EGFR., Uveal melanomas express HGF, c-Met, EGFR, and IGF-1R, Nuclear EGFR correlated with shorter overall survival in whole cohort and in the premenopausal group of patients with ductal invasive breast cancer., Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8., In ovarian cancer cells highly responsive to lysophosphatidic acid (LPA), activation of AP-1 by LPA was suppressed by inhibition of EGFR while NF-kappaB was stimulated via the Gq-PKC pathway in an EGFR-independent manner., simultaneous detection of p53, Rb, p16, and EGFR in a suspension microarray facilitates rapid diagnosis of lung cancer, In the Ecuadorian population, L858R and G719S mutations are mainly found in NSCLC, in women, nonsmokers, and individuals with adenocarcinoma, These findings suggest an essential role of Nedd4-1 in regulation of EGFR degradation through interaction with and ubiquitination of ACK., These results indicate that PXK plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor., No specific computed tomography appearance, which would correlate with either an EGFR mutation or a KRAS mutation was associated with adenocarcinoma of the lung with bronchioloalveolar features., Hyaluronan can serve as a signal integrator by facilitating TGF-beta1-mediated CD44-EGF-R-ERK interactions and ultimately fibroblast phenotype., The EGFR expression in the primary tumor and the corresponding metastasis is discordant in about 10% of the patients, Findings offer a mechanistic explanation for the limited efficacy of irreversible EGFR inhibitors in EGFR(T790M) gatekeeper-mutant tumors., EGFR mutation was recognized in approximately 20% of patients with pulmonary pleomorphic carcinoma., Features of KRAS mutations in lung cancer and contrast these with the features of EGFR mutations., miR-21 inhibitor might interrupt the activity of EGFR pathways, independently of PTEN status, EGFR mutations did not correlate with pAkt and pERK expression in lung adenocarcinoma., Elevated expression level of EGFR is associated with a low response to chemoradiation in rectal cancer., although EGFR is expressed in most epithelioid sarcomas regardless of subtype, gene amplification and activating mutations in the tyrosine kinase domain appear to be rare or absent., EGFR-PTP1B interaction occurs by means of direct membrane contacts between the perimeter membrane of multivesicular bodies (MVB) and the endoplasmic reticulum. PTP1B activity promotes the sequestration of EGFR on to MVB internal vesicles., Simultaneously blocking EGFR and COX-2 mediated pathways would significantly inhibit the growth of the CNE-2 cell line, increase G1 arrest and reduce the expression levels of p-EGFR and COX-2., The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue., PAR-2-mediated sVEGFR-1 release depended on protein kinase C-beta(1) and protein kinase C-epsilon, which required intracellular transactivation of epidermal growth factor receptor 1 in endothelial cells, Activation of the epidermal growth factor receptor (EGFR) pathway emerges as a resistance mechanism in MET-amplified cells after prolonged exposure to PF2341066., Overexpression of EGFR pathway-related genes in the circulation is highly correlated with EGFR mutations and overexpression in paired cancer tissue from patients with non-small cell lung cancer., Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively of glioblastoma multiforme, The p53 protein expression was higher in a group of adenocarcinomas having the EGFR L858R mutation than in that of adenocarcinomas with EGFR mutation in exon 19., Data show that a unique gene, KLHDC8, herein referred to as KLHDC8A/SDeltaE (Substitute for DeltaEGFR Expression)-1, is highly expressed in these tumors, which have escaped dependence on DeltaEGFR., microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation, Overview of the current understanding of the lung adenocarcinoma subset harboring EGFR mutations with special reference to the molecular classification of lung cancer and the novel concept of the "terminal respiratory unit.", High VEGFR2 expression, EGFR expression, and EGFR gene copy number were significantly correlated to triple-negative breast cancer, In amnion cells EGFR clustering induced by 50-Hz MF depends on acid sphingomyelinase activity., Mutations in TP53, KRAS, or EGFR are not major contributors to the RCC development even in the absence of VHL inactivation., These findings demonstrate that hypoxia activates EGFR tyrosine kinase, leading to arginase expression and thereby promoting proliferation in human pulmonary microvascular endothelial cell., Vav2 can regulate growth factors receptor signalling by slowing receptor internalization and degradation through its interaction with endosome-associated proteins., E5 and the EGF-receptor cooperate to enhance cell cycle entry and progression through regulating p27(Kip1) expression at protein level., Results highlight the role of TI-VAMP in the secretory pathway of a tetraspanin, and support a model in which CD82 allows EGFR entry in microdomains that control its clathrin-dependent endocytosis and signaling., These findings indicate the existence of the nuclear EGFR/EGFRvIII signaling pathway in GBM and its functional interaction with STAT3 to activate COX-2 gene expression., Mutation in the epidermal growth factor receptor gene confers sensitivity to the EGFR tyrosine kinase inhibitors in leptomeningeal metastases., Mutations in EGFR is associated with lung adenocarcinoma., EGFR signaling can regulate MET levels through HIF-1alpha and that MET is a key downstream mediator of EGFR-induced invasiveness in EGFR-dependent NSCLC cells., A high proportion of in situ SCCs already have increased EGFR gene copy numbers, but these alterations do not seem to play a role in the progression from low-grade SCCs into more aggressive phenotypes., modulation of EGFR phosphorylation may explain how gangliosides contribute to regulate the lactogenic hormone-induced mammary cell differentiation, Additional role of chemotherapy and the management of tumours with the secondary T790M mutation that confers resistance to EGFR TKIs., EGFR -191C/A, -216G/T, and R497K polymorphisms are associated with diarrhea when using gefitinib in non small cell lung cancer patients., The expression of EGF in lymph nodes was related to lymph node EGFR level., The lack of positive correlation between EGFR protein expression and gene copy number suggests that mechanisms unrelated to gene amplification are involved in activating EGFR, Human cytomegalovirus engages the epidermal growth factor receptor to facilitate upregulation of myeloid cell leukemia sequence (Mcl)-1 and acquisition of the apoptotic resistant phenotype in infected monocytes., In Chinese patients with CRC, EGFR mutations were rare, and K-ras mutations were similar to those of Europeans., Mutations in the epidermal growth factor receptor gene is associated with response to treatment with EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer., Non-small cell lung cancer harboring sensitizing EGFR Mutations are associated with osteoblastic responses during disease control by tyrosine kinase inhibitor treatment., depletion of p38alpha MAP kinase activity suppresses EGF receptor signaling and downstream Erk MAP kinase signaling, as well as autocrine EGF receptor-dependent proliferation., Overexpression of Egr-1 is caused by mutation of p53 and appears to be initiated through activation of the MEK/ERK1/2 signaling cascade by mutant p53., There might be a cross-talk of bi-directional control between Notch1 and EGFR signaling in regulating the cellular proliferation of human tongue squamous carcinoma cells., the gene expression profiles of lung adenocarcinoma are linked to histopathological grading and survival but not to EGF-R status, This study is, to our knowledge, the first to perform a comprehensive tagging of the EGF and EGFR genes in glioblastoma, Have studied internalization of two EGFR-binding Affibody molecules, Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway., The affibody molecule (ZEGFR, EGFR genome modulation in the CD44+/CD24-/low subpopulation of the breast cancer cell line MDA-MB-468 leads to different coexisting subclones, EGFR, HER-2 and HER-4 expression is not associated with poorer survival in neuroendocrine cancer, The results demonstrated the presence of intratumor molecular heterogeneity for the clinically relevant EGFR mutated alleles in these early-stage lung tumors, Alterations in the EGFR-PTEN signaling pathway are present in a third of prostate adenocarcinomas, particularly affecting the more advanced cases., dimers were enriched in the cell periphery in an actin- and receptor-expression-dependent fashion, resulting in a peripheral enhancement of EGF-induced signalling that may enable polarized responses to growth factors, activation of Pyk2 is an early signal that promotes wound healing by stimulating the SFK/EGFR signaling pathway., ErbB/PI3K/Akt/NF-kappaB signalling in the progression of prostate cancer, YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas., Data show that EGFR mutations in exon 19 or 21 are associated with low exposure to cigarette smoke, whereas EGFR mutation in exon 20 is more common in smokers., EGFR signaling regulates beta-catenin localization and stability, target gene expression, and tumor progression in oral cancer., there was a trend toward an association between shorter overall survival time and epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization analysis., These data suggest that the rs884419 polymorphism flanking the EGFR gene is an independent prognostic genetic biomarker that predicts prostate cancer biochemical recurrence after radical prostatectomy., Propose that EGFR amplification is an important and frequent pathway in glioblastomas., sulindac metabolite-induced downregulation of EGFR seems to be mediated through mechanism(s) similar, at least in part, to those involved in EGF-induced downregulation of EGFR., data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation, EGFR expression is a common feature in MPM patients. High pre-treatment levels of serum EGFR are associated with advanced stage but not with reduced OS., TGF-beta-enhanced EGFR signalling may be an important contributor to barrier dysfunction and increased epithelial vulnerability in response to house dust mites, Mig-6 controls EGFR trafficking and suppresses gliomagenesis, the EGFR gene polymorphism might be associated with presence of asymptomatic airway hyperresponsiveness in young allergic adults, Data show that the ACK1 S985 N mutant is unable to bind ubiquitin, which contributes to ACK1 protein stability and stabilizes EGFR after EGF stimulation, thereby prolonging mitogenic signaling in cancer cells., Heterozygosity status of 1p and 19q and its correlation with p53 protein expression and EGFR amplification in patients with astrocytic tumors., Biglycan impinges on the expression of total EGFR and possibly, on the cell-surface expression of the receptors, playing a critical role in the regulation of chondrocyte and pericellular matrix homeostasis., EGFR gene mutation and high EGFR expression is associated with salivary duct carcinoma., 528scFv-TRAIL may have a role in treatment of EGFR-expressing cancers, up regulation of EGFR, cyclin D1 and h TERT proteins correlates with advanced stage in squamous cell carcinoma of the larynx, It appears that an increase in EGFR/CEP7 ratio to cutoff point of 4.5 may distinguish between coexisting EGFR (FISH ratio of >5) or KRAS (FISH ratio of 2 to 5) mutations., EGF receptor tyrosine phosphorylation in lung cancer cells is regulated by Neuromedin B receptors., The EGF-receptor is mutated in a large variety of tumors. We review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Review., HtrA1 has a role in promoting anoikis by attenuating activation of EGFR/AKT pathway that may contribute to its metastasis suppression capacity, HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia., Stepwise COX regression analyses suggested that EGFR rs373506, rs759165 and rs6958497 may be independent candidate biomarkers to predict NSCLC survival in this population, There was no statistically significant correlation between EGFR expression and clinical stage, age, histology, tumor size, tumor grade, lymph vascular space invasion, lymph node status and disease recurrence., Protein kinase C (PKC)zeta is a novel mitogenic downstream mediator of epidermal growth factor (EGF) receptor, and a therapeutic target as well, in some carcinomas., EGFRvIII mRNA can be detected in the serum of hepatocellular carcinoma patients., These results indicate that imbalance alterations at several chromosomal regions occur significantly more frequently in lung adenocarcinomas with EGFR mutations than in those without such mutations., The length of the EGFR intron 1 CA repeats does not correlate with levels of EGFR expression and cannot be used as marker of clinical prognosis in pancreatic cancer patients., Subsets of patients with colon adenocarcinoma demonstrate specific protein/gene alterations regarding EGFR/VEGF/HIF1a molecules., EGFR and FCGR3A germline polymorphisms are associated with progression-free survival in KRAS wild-type metastatic colorectal cancer patients treated with cetuximab, bevacizumab and chemotherapy., Results showed a comparable rate of EGFR kinase domain mutations in lung adenocarcinomas from Chinese male and female never-smokers., Fatty acid-binding protein 5 and PPARbeta/delta are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth, EGFR signaling blockade or EGFR knockdown attenuated TGF-beta1-induced PAI-1 expression, implicating EGFR transactivation in TGF-beta1-stimulated PAI-1 expression, EGFR and Her-2 may not have a role in oral squamous cell carcinoma, but there are low levels of EGF in saliva during disease progression, Results suggest that the expression of c-erbB-2 and EGF protein, but not necessarily ERG receptors, can help predict the postoperative survival time in stomach cancer., The single-clone model indicates subsequent disease progression, whereas genetic alterations from mutations to wild-type EGFR are suggestive of second primary carcinoma in patients with adenocarcinomas with a bronchioloalveolar carcinoma component, Findings in the EGFR gene suggest that germline genetic variants of EGFR in neuroepithelial cancer stem cells may be involved in glioma development., The present data demonstrate that sLe(x), in association with EGFR, in normal human bronchail epithelial cells, is coordinate with repair., p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells., Results suggest that the transactivation circuit acts as a context-dependent integrator and amplifier of multiple extracellular signals and that signal integration can effectively occur at multiple points in the EGFR pathway., Lapatinib, a dual tyrosine kinase inhibitor of EGFR and HER-2 receptors demonstrated antiangiogenic/antitumor effects in a lung cancer model., EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but protein expression was detected in the majority of the cases. EGFR amplification was seen in tonsil but not in anal canal carcinomas., Data suggest implications of future therapeutic targets development for EGFRvIII-positive glioblastoma patients., Data show that inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression., Data show that the presence of wound edges is sufficient to cause activation of the EGF receptor and increased motility of cells in the absence of other cues., The EGFRvIII-dependent glioblastoma multiforme cell transformation is associated with the onset of the simultaneous overexpression of tissue factor, protease-activated receptors 1 and 2, and ectopic synthesis of factor VII., EGFR sequence analysis was the only method useful for predicting response and progression-free survival following tyrosine kinase inhibitor therapy in non-small cell lung carcinoma., SIRPalpha1 specifically affects the SHP-2/FAK/Grb2/Sos-1/MAPK activation loop to downmodulate EGFRvIII-mediated migration and transformation., Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion., results demonstrate that CHFR loss might be critical for the tumorigenesis of NSCLC in patients with a history of smoking and induces tumors of a more malignant phenotype than the EGFR mutation, Mutation in EGFR is associated with Neratinib response in non-small-cell lung cancer., Data report that Met protein expression and phosphorylation were associated with primary resistance to EGFR TKI therapy in NSCLC patients harboring EGFR mutations, implicating Met as a de novo mechanism of resistance., Studies indicate the involvement of EGFR(s) in regulating events of GI cancers during advancing age., Mutations may predict the biological nature of pulmonary adenocarcinomas and facilitate new therapies., EGFR and MAPK are actively involved in the pathobiology of serous cystic neoplasms of the pancreas., This is the first study to show that DJ-1 immunoreactivity is present, and robust, in most glioblastomas (GBMs), and that DJ-1 staining intensity in GBMs varies directly with p53 nuclear immunoreactivity and inversely with EGFR amplification., This research was carried out to determine if conjunctival squamous cell carcinoma harbors human papillomavirus DNA and is associated with activation of the EGFR signaling pathway., Gefitinib may be considered as an upfront treatment option for EGFR-mutated NSCLC., analysis of EGF receptor activation under the action of lipopolysaccharide on human A431 carcinoma cells, The inhibitory effect of the GHRH antagonist JMR-132 on proliferation is due, in part, to an interference with the EGFR-Akt pathway in ovarian cancer cells., High EGFR expression is associated with meningioma., These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity., Epidermal growth factor receptor mutation is associated with early stage of pulmonary adenocarcinoma development and tumor initiation from the preneoplastic lung parenchyma to neoplastic conditions., EGFR mutations are associated with erlotinib at a dose of 25 mg daily for non-small cell lung cancers., SH3GL2 participates in the regulation of apoptosis through the MEK-ERK signal pathway by adjusting EGFR in the laryngeal carcinoma cell line Hep2, Clathrin-dependent endocytosis of EGFR is regulated by four mechanisms involving ubiquitination of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein, and the acetylation of three C-terminal lysine residues., Multiple basolateral pathways mediate EGF receptor sorting in renal epithelial cells., Genetic and functional interactions between COMT and AKT1 may provide novel insights into pathogenesis of schizophrenia and other ErbB-associated human diseases such as cancer., Somatic epidermal growth factor gene point mutation is associated with Good clinical response to gefitinib in non-small cell lung cancer., Rhinovirus induced MUC5AC in bronchial epithelial cells in vitro by activating an epidermal growth factor receptor-dependent cascade culminating in specificity protein-1 transactivation of the MUC5AC promoter., EGFR overexpression was seen in some of the malignant hidradenomas,atypical hidr- adenomas, and benign hidradenomas., Pgrmc1 associates with epidermal growth factor receptor and regulates erlotinib sensitivity, A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR., ErbB-1 shows absent immunoreactivity in meningioma and indicates a level similar to that of ErbB-1 in normal peripheral nerve., EGFR mutations are associated with HLA-A2 in female patients with adenocarcinoma of the lung., PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells., Data show that inhibition of PA hydrolysis provokes internalization of inactive EGFR, accompanied by a transient increase in PA levels and PDE4s activity., EGFR mutations are associated with lung adenocarcinomas., EGFR gene mutations are not associated with non-small cell lung cancer., Akt has a pivotal role in EGFR-mediated cell migration, HER2, but not EGFR gene amplification, is frequently observed in KRAS and BRAF wild type colorectal cancer patients, Studies indicate that both fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating skeleton developments and grows pathways., Report the expression and drug targeting of the EGFR in cholangiocarcinoma cell lines., epidermal growth factor receptor is expressed in precancerous oral lesions, Type I Ishikawa H and type II Hec50co endometrial carcinoma cells both express EGFR and sEGFR, but differ markedly in their responsiveness to the EGFR inhibitor gefitinib, SCCA, EGFR and cyclin D1 may prove to be useful tumor markers in oral squamous cell carcinoma., HB-EGF participate in transactivation of EGF receptor under oxidative stress., analysis of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors, study to correlate EGFR expression between primary colorectal cancer and liver metastatic sites, and to assess mutational status in the EGFR kinase domain; EGFR expression in the primary tumor site was not predictive of its level in the metastasis, GRP promotes the growth of HepG2 cells through interaction with GRPR co-expressed in tumor cells, and subsequently activates MAPK/ERK1/2 via EGFR-independent mechanisms., In migratory cells ablation of myosin VI or optineurin inhibits the polarized delivery of the epidermal growth factor receptor into the leading edge and leads to profound defects in lamellipodia formation., EGFR phosphorylation is commonly encountered in breast carcinomas, Results suggest that overexpression of EGFR protein and increased copy number or amplification of the EGFR gene occur relatively frequently in primary TGCTs, and may play roles in the formation of invasive cancer and in the progression., There was a substantial increase of NHEJ activity, when EGFR was activated by EGF as determined for two different reporter cell lines (A549.EJ and H1299.EJ) and, vice versa, a reduction was seen when EGFR signalling was blocked by Cetuximab or erlotinib., EGFR overexpression is associated with advanced colorectal adenomas. Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression., results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-alpha, Data show that Spry2 can enhance the response of colon cancer cells to gefitinib by increasing the expression of phosphorylated and total EGFR., EML4-ALK fusion gene was present at a high frequency in Chinese NSCLC patients, particularly in those with adenocarcinomas lacking EGFR/KRAS mutations, In nonsmall cell lung cancer patients with brain metastases, EGFR mutation status is associated with improved survival, EGFR mutation is associated with high chemotherapy response rate of non-small cell lung cancer., Overexpressions of nuclear EGFR is associated with non-small cell lung cancer., A significant correlation between EGFR expression at the invasive margin and the presence of budding was seen, High EGFR expression, copy number and mutation is associated with lung adenocarcinomas., Data show that ErbB3 appears to be critically involved in EGFR signaling as evidenced by its profound effect on cellular proliferation and its ability to influence response to EGFR-targeted therapy., the inhibition of amphiregulin expression, which impairs EGFR response to its exogenously available ligands, may represent an alternative anti-EGFR therapeutic strategy in breast cancer., 2 cases of pulmonary adenocarcinoma with unique microcystic growth pattern; Q787Q polymorphism was found in microcystic component but not in papillary component; findings illustrate intratumoral heterogeneity of EGFR gene polymorphism, the ratio of ErbB1 and ErbB2 in their heterocluster, EGFR gene mutations are associated with lung adenocarcinomas with features of the non-mucinous subtype of bronchioloalveolar carcinoma., The EGFR/ERK pathway is activated in high-grade MECs with aggressive behaviour., A potential role the nuclear EGFR may play in tumor response to radiation, chemotherapy, and EGFR-targeted therapy, is reviewed., Signaling by the neuregulin-1beta/ErbB pathway regulates the ratio of sinoatrial node- to working-type cardiomyocytes in differentiating embryonic stem cell cultures and presumably functions similarly during early human heart development., Overexpression of EGFR and COX-2 may play an important role in the tumorgenesis, progression and malignancy of lung cancer. Detection of EGFR and COX-2 expression might be helpful to diagnosis and prognosis of lung cancer., nuclear transport of EGFR is regulated by COPI-mediated vesicular trafficking from the Golgi to the ER, and may serve as a general mechanism in regulating the nuclear transport of other cell surface receptors., EGFRvIVa and EGFRvIVb mutants that lack internal segments distal to the intracellular tyrosine kinase domain confer an oncogenic potential, astrocytic ErbB signaling in neuron-glia interactions has significance for the physiology of the mature central nervous system, as exemplified by the central control of reproduction within the hypothalamus--REVIEW, Activating epidermal growth factor receptor mutations are associated with response to gefitinib in non-small cell lung cancer., cystic carcinomas of the breast have low Topo IIalpha expression but frequently overexpress EGFR protein without EGFR gene amplification., Mutation of Thr654, located within the putative EGFR NLS demonstrated that phosphorylation of this residue is essential for nuclear EGFR shuttling following irradiation., our results suggest that the expression of EGFR in adrenocortical tumors indicates a malignant phenotype, Epidermal growth factor receptor mutations are associated with better response to therapy in non-small cell lung cancer., A strong positive correlation between EGFR amplification and EGFR overexpression and a negative association of EGFR amplification and EGFR overexpression with p53 immunopositivity was observed., Overexpression and activation of epidermal growth factor receptor is associated with hemangioblastomas., EGFR activated AKT and inactivated GSK3beta, data indicate HER1 signaling (mediated by HBEGF; involving PIK3 signaling and phosphorylation of HER1) is an important component of differentiation of proliferative extravillous trophoblasts (ET) into invasive ET; HER1 likely involved in placentation, Data show that neurostatin inhibits epidermal growth factor receptor signaling pathways, blocking activation of MAPKs and PI3K pathways, interferes in the cell cycle progression, and promotes generation of angiogenic and invasive responses., observed a positive correlation of the nuclear expression of EGFR, RNA helicase A, and cyclin D1 in human breast cancer samples, molecular beacon-based approach enabled rapid and sensitive detection of the EGFR mutation (T790M) in NSCLC with in situ fluorescence imaging, which can be directed to determine various treatment options in patients with cancer, complex EGFR mutations is associated with different efficacy to gefitinib in non-small cell lung cancer., quantification of EGFR and HER3 mRNA expression in pretreatment biopsies may be useful to identify patients who are at risk of developing metastases, Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors., These results suggest that linkage between ligand-induced dimerization and tyrosine kinase activation in the epidermal growth factor receptor is much looser than was previously envisioned., Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis, Expression level of EGFR protein and mutation frequency of KRAS gene in primary tumors were higher than that in metastases., data show that EGFR gene copy number and KRAS mutation status are neither predictive nor prognostic factors for pathological tumour response and disease-free survival in locally advanced rectal cancer patients treated with preoperative chemoradiation, Study shows that chromogenic in situ hybridization is a valid method to detect EGFR gene copy number in cell blocks from fine needle aspirates of primary/metastatic lung neoplasms., findings define a novel interaction between EGFR and Notch pathways in the adult subventricular zone, and thus provide a mechanism for neural stem cell and neural progenitor cell pool maintenance, Activation of the EGF-EGFR signaling pathway is associated with the development of CK19-positive hepatocellular carcinoma (HCC), and the EGF-induced increase in growth abilities of HCC may account for the poor prognosis of the patients., Overexpression of EGFR is associated with pelvic relapse in advanced cancer of the cervix treated with chemoradiotherapy., Epidermal growth factor receptor mutation is associated with lung cancer., EGFR gene mutation is associated with non-small cell lung cancer., Data indicate that that a constitutively active transforming form of Src, the E378G mutant, as well as v-Src enhance ADAM17-mediated shedding of the EGFR ligand TGFalpha., We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations., Serine/threonine phosphorylation reduces the binding affinity between the TKB domain of c-Cbl and its target proteins, EGFR and Sprouty2., TGFA/EGFR signaling contributes to the proliferation of papillary thyroid carcinomas cells., Knockdown of RQCD1 reduced the Akt phosphorylation level that was induced by epidermal growth factor (EGF) stimulation, Mutations in EGFR is associated with adenocarcinoma of the lung., Data provide substantial evidence that APP and cystatin C are target secreted proteins of EGFR in NPC, and upregulation of secretory APP by EGFR may be involved in the pathogenesis of NPC., When patients with lung adenocarcinomas who had EGFR mutations developed pulmonary metastases, they tended to be diffuse and random, including military metastases., more than 60% of non-small cell lung carcinomas (NSCLCs) express EGFR, Results suggest that LTD induces EGF receptor transactivation through the release of HB-EGF in human bronchial epithelial cells with downstream release of CXCL8., PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells, Data indicated that the mitochondrial-localized EGFR is independent of its internalization and may be correlated with cell survival and participate in the ligand-induced programmed cell death., Report on the clinical utility of reflex testing of resected stage I through III lung adenocarcinomas for EGFR and KRAS mutatations., Estrogen receptor alpha36 mediates nongenomic estrogen signaling through the epidermal growth factor receptor/Src/extracellular signal-regulated kinase signaling pathway in estrogen receptor-negative breast cancer cells., Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR., Immunohistochemical analysis of p-EGFR may be useful to predict responses to TKI therapy, although future studies are necessary., Cbl ubiquitin ligase plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR-Vav2 signaling., EGFR oligomerization is the result of EGFR signaling and enhances EGFR internalization, The novel EGFR mutations identified are activating mutations responsive to erlotinib. The mut+ subset have a 'relative' improved outcome., enhanced EGFR expression on keratinocytes in OLP lesions and up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to carcinogenesis and pathogenesis of OLP., insight into the ErbB2-driven anchorage independence of tumor cells and provide a new mechanism for regulation of EGFR and beta1 integrin expression in ECM-detached cells, cIAP2 upregulated by E6 via EGFR/PI3K/AKT cascades may contribute to cisplatin resistance, revealing that the EGFR or PI3K inhibitor combined with cisplatin may improve the chemotherapeutic efficacy in HPV-infected lung cancer., elevated plasma levels of epidermal growth factor receptor are associated with breast cancer among hormone therapy users., EGFR and HER-2 expression is variable in embryonal brain tumors, EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner., Demonstrate a chip capillary electrophoresis (chipCE) application for EGFR mutation detection by a combination of fragment analysis and denaturing CE along with multiplex ligation-dependent probe amplification (MLPA) for evaluation of EGFR amplification., Gefitinib and Erlotinib induce responses in over 70% of non-small cell lung carcinoma patients harboring EGFR mutations, with progression-free survival., non-small cell lung cancer specimens harboring EGFR activating mutations are more likely to express low ERCC1 mRNA levels., Overexpression of EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF., EGFR mutations promote the growth of NSCLC, but may not be a factor of predicting prognosis., EGFR mutations are associated with drug sensitivity in non-small-cell lung cancer., EGFR-activating mutations were not present in the Japanese breast cancer series studied here., Constitutive activation of EGFR/Akt/mTOR pathway was present in defined subset of nonsmall cell lung carcinomas., The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells., data demonstrate that the tethering arm plays an important role in supporting cooperativity in ligand binding, Src pathway and EGFR pathway play different roles in the proliferation of cervical cancer cells and PP2 efficiently reduces cervical cancer cell proliferation by reduction of both Src and EGFR activity., EGFR gene mutations were frequently observed in not only non-small-cell lung cancer (NSCLC), but also in ovarian cancer in Japanese patients., High Epidermal growth factor receptor and caveolin-1 coexpression is associated with supratentorial ependymomas., The EGFR T790M mutation is the main molecular mechanisms responsible for acquired resistance to gefitinib or erlotinib in patients with non-small cell lung cancer harboring a mutation in the EGFR gene., EGFR mutations in exon 19 and exon 21 in non-small cell lung cancer patients may relate to the tumor sites, p53 and EGFR mutations are uncommon in lymphoepithelioma-like carcinomas (LELC), indicating that these genes are not the important events in carcinogenesis for this tumor subtype., Expression of EGFR pathway components does not appear to have prognostic impact in surgically treated early-stage cervical cancer., V3 isoform of versican interferes with CD44 and the CD44-EGFR/ErbB2 interaction, altering the signaling pathways, such as ERK1/2 and p38 MAPK, that regulate cell proliferation and migration, In breast cancer patients, early T stage, clinical response after 2 cycles, negative basal-like, negative EGFR, high Ki-67 proliferation index, and positive nm23-H1 were found to be significantly predictive of a pathological complete response., Both SGLT1 and EGFR overexpression in colorectal cancer was related to higher clinical stages., Phosphorylation sites related to activating mutations in EGFR as well as sensitivity to erlotinib were identified using 31 lung cancer cell lines., Significantly fewer EGFR (epidermal growth factor receptor)-mutated tumors engrafted (P = 0.03)., Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis, Data provided a mechanistic description of the disorders of mutated EGFR signaling networks, which could facilitate the development of a systematic strategy toward controlling disease-related cell signaling., Calcium-induced apoptosis in bladder cancer cells is delayed by HER1 receptor activation involving the Akt and PLCgamma signalling pathways., Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas., these results unveil a critical role of EGFR acetylation that regulates EGFR function, which may have an important clinical implication., Mutations of EGFR, BRAF, and KRAS in adenocarcinoma were mutually exclusive and inversely correlated with RASSF1A methylation, Overexpression of ErbB-1 and ErbB-2 was associated with poor prognostic features and decreased 5-year disease-free survival in breast cancer patients., Exon 19/21 mutations and high EGFR copy is associated with response to adjuvant chemotherapy in non-small cell lung cancer., There was no difference between the frequencies of EGFR mutations in African American patients, when compared with whites., results suggest that EGFR activation and downstream signaling depend on interactions of EGFR with PIP(2) and point to the basic juxtamembrane domain's critical involvement in these interactions, EGFR might be, for the cases of colorectal cancer with high EGFR expression in metastases, a target for radionuclide therapy, IL-6 stimulates shedding of EGF-R ligands and transactivation of EGF-R in normal prostate epithelial cells, which may be an important mechanism to promote cell proliferation in inflammatory prostate., The frequency of EGFR mutation in Chinese non-small cell lung cancer patients is higher than that in Westerners, but the frequency of K-ras mutation is quite opposite., Study describes a role for ERbeta in the modulation of cell proliferation and EGFR activation., extracellular HSP90alpha transactivates EGFR/ErbB1 through TLR4 and a PKCdelta/c-Src pathway, which induces ATP release and cytosolic Ca(2+) increase and finally favors glioblastoma cell migration., The epidermal growth factor receptor (EGFR) pathway is the main regulator of cell function and cancer development. [review], five EGFR mutations out of 16 patients with NSCLC of African-American descent, This study aimed to analyze the relationships between IPF and specific EGF receptor family functional polymorphisms., analysis of resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer, data demonstrate glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure; defects are due, at least in part, to lack of antagonism between GR and epidermal growth factor receptor signaling, Lung adenocarcinomas harboring mutations in EGFR exon 19 or 21 are associated with improved treatment response., age at the time of diagnosis in female patients with non-small cell lung cancer may be associated with the frequency of EGFR mutations., Activation of EGFR and its subsequent interaction with PKCdelta under inflammatory conditions might positively be attributed to the neoplastic transformation of normal esophageal epithelia., telomerase expression and activity are induced through both direct phosphorylation of hTERT by phospho-AKT as well as PI3K-dependent transcriptional regulation involving Hif1-alpha as a key transcription factor, membranous EGFR expression is associated with increased gene copy number in triple-negative breast carcinoma, EGFR is overexpressed during the histological progression in Barrett's esophagus tissues, The expression of EGFR mRNA in tumor tissue was positively correlated with EGFR protein in plasma., The overexpressions of VEGF-C and EGFR genes are closely related to lymph node metastasis. VEGF-C mRNA and EGFR mRNA are valuable biomarkers for early diagnosis, clinical prediction and prognosis for lung cancer., Results indicate that downregulation of survivin plays a pivotal role in gefitinib-induced apoptosis in EGFR mutation-positive NSCLC cells., EGFR-mutated lung cancer, Case Report, APC activates Tie2, via a mechanism requiring, in sequential order, the receptors, endothelial protein C receptor, protease-activated receptor-1, and EGF receptor, which selectively enhances the PI3K/Akt signaling to enhance junctional complexes, combined expression of three genes-MYC, EGFR and FGFR2-was an independent predictor for overall survival of 27 CF-treated patients in the validation set, and also for survival of 40 chemotherapy-treated gastric cancer patients, Epidermal growth factor receptor mutations are associated with small cell lung cancer., epidermal growth factor receptor exon 19 deletion is associated with Miliary never-smoking adenocarcinoma of the lung., In a group of clinically selected patients, EGFR and KRAS analysis was able to define distinct molecular subsets of lung adenocarcinoma., Pulmonary adenocarcinoma specimens were prepared for staining by two antibodies that recognise products of in-frame deletions in exon 19 (E746_A750del) and a point mutation at codon 858 in exon 21 (L858R) of the EGFR gene., These data indicate that the activation and/or overexpression of SST receptors along with the inhibition of EGFR will serve as an important therapeutic approach in the treatment of ErbB-positive tumors., high tumor CB(1) receptor expression at diagnosis augments the deleterious effects of a high pEGFR expression upon disease-specific survi, Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor., the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation., Results describe an open, mass spectrometry-based approach to identify tyrosine phosphorylations associated with AEGFR, and have identified STAT5 as a new target for this receptor., Sequence analysis of the EGFR-TK domain, revealed the presence of (G2607A) polymorphism at exon 20. The genotypes AA and GA were found respectively in 39 and 16 cases., Data show that [18F]F-PEG6-IPQA preferentially covalent binds to the L858R mutant EGFR kinase domain., Data sugggest that The inhibition of EGFR and VEGFR2 by vandetanib and its tremendous in vivo antitumor activity against ATC make it an attractive candidate for further preclinical and clinical development for the treatment of this cancer., EGFR and nm23 can serve as reliable biomarkers for prognosis prediction in patients with nasopharyngeal carcinoma who may benefit from alternate treatment strategy and targeted treatment., There is a positive correlation between the EGFR and c-Met protein expression and the differentiation of non-small cell lung cancer., EGFR, PI3Kp110 and PTEN expression is a common feature of neuroblastoma, Rapid and accurate ranking of binding affinities of epidermal growth factor receptor sequences with selected lung cancer drugs, TGF-alpha and EGFR were overexpressed, correlated with each other and associated with the pathological parameters in papillary thyroid carcinoma., Quantitative analysis of EGFR mRNA expression could be useful in predicting prognosis and sensitivity to gemcitabine in pancreatic ductal adenocarcinoma patients., Findings suggest an improved method to identify EGFRvIII-expressing gliomas in vivo that are best suited for treatment with therapeutic EGFR antibodies., TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes., The epidermal growth factor receptor-L861Q mutation increases kinase activity without leading to enhanced sensitivity toward epidermal growth factor receptor kinase inhibitors., Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations are associated with non-small cell lung cancer patients, EGFR T790M mutation resistance to EGFR-tyrosine kinase inhibitors is overcome by vascular endothelial growth factor inhibitors., Findings suggest strategies to target nucleolin as a general approach to inhibiting ErbB- and Ras-driven cancers., Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion, Data show distinct significant correlations between TITF-1 protein expression and DNA copy gain with mutations in the lung adenocarcinoma-prevalent EGFR and KRAS oncogenes., EGFR mutations are associated with drug resistance in non-small cell lung cancer., Data suggest that PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation., Galectin-3 regulates MUC1 and epidermal growth factor receptor (EGFR) internalization and subcellular localization, ERK1,2 activation downstream of the EGFR and EGFR nuclear translocation in pancreatic cancer cells., VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis., the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathways, High EGFR expression is associated with triple-negative breast cancer., Membrane EGFR over-expression in resected pancreatic cancer patients was associated with worse clinical outcomes, Data suggest that accurate definition of the EGFR status could improve prognostic stratification and suggest a possible role for EGFR-directed therapies in PC patients., Study observed that CREB was phosphorylated following transactivation of EGFR by c-Src in EV71-infected cells., P2Y6 receptors and ADAM17 mediates the low-dose gamma-radiation-induced activation of EGFR., increasing cell motility is down to the production of matrix metalloproteinase 9, which degrades the basement membrane during tumor invasion, and metastases are caused by the activation of EGFR, High EGFR expression is associated with tamoxifen-resistance in breast cancer., K497 EGFR polymorphism is associated with sensitivity to inhibitors in head and neck squamous cell carcinomas., EGFR extracellular domain forms dimer that can take diverse configurations in solvent environments, ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking., the expression of CD133 and Her-1 may be correlative with prognosis in triple-negative breast cancer., a high frequency of Q787Q mutation and a less prevalent active EGFR mutation in oral cavity squamous cell carcinoma patients in Taiwan where betel nut is commonly chewed., Manipulation of miR-145 expression modulates EGFR mRNA expression., Detection of EGFR expression and mutation in Pulmonary blastoma, Local haplotype structures across the EGFR gene may favor the development of cellular malignancies and thus significantly confer risk to the occurrence of EGFR mutations in NSCLC, particularly the exon 19 microdeletions., Polymorphism in epidermal growth factor receptor intron 1 is associated with treatment response in esophageal cancer., Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients., EGFR activation by its potent ligand, transforming growth factor (TGF)-alpha, induces reactivation of EGFR via binding of endogenously produced CCL20 to its receptor CCR6 in NCI-H292 tumor cells, exaggerating the mucin production in NCI-H292 cells., high prevalence of EGFR mutations in non-smal cell lung cancer patients in India, EGFR mutation is associated with response to therpay in non-small cell lung cancer., A859T EGFR mutation is associated with lung cancer., Epidermal growth factor receptor gene mutations is associated with squamous cell lung carcinoma., HER overexpression orchestrates broad changes in the tumor microenvironment by altering the secretion of a diverse variety of biologically active proteins., Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells., The contiguous angiomyolipoma (AML) demonstrated strong positivity for EGFR, a feature not observed in isolated AMLs., Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck., airway epithelial exposure to Pseudomonas fluorescens can trigger antiapoptotic responses via EGFR, Trastuzumab plus chemotherapy in gastric cancer overexpressing HER-2 and EGFR, EGFR appears to be involved in progression and metastasis of a subset of melanomas, role of EGFRvIII in cohort of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with or without EGFR tyrosine kinase inhibitor; study confirms EGFRvIII mutation is common in R/M SCCHN and may play role in prognosis, EGFR and c-Met may interact in a synergistic manner in the oncogenesis and development of non-small cell lung cancer. Expressions were higher in smokers than in nonsmokers., REVIEW, Injury and activation of purinergic receptors and direct activation of EGFR via EGF induce distinct downstream pathways., EGFR exon 19 deletions and exon 21 point mutation are predictive biomarkers for response to icotinib hydrochloride as second line treatment or above., Expression of EGFR was associated with late staging of gastric carcinoma. Overall 5-year survival rate was significantly higher in patients with EGFR negative expression., HSV-1 entered endosomes using either EGF or an EGFR-specific single chain antibody for receptor recognition., demonstrate here that breast cancer cells harbouring PIK3CA mutations are selectively sensitive to mTOR allosteric and kinase inhibitors. However, cells with PTEN loss of function are not sensitive to these drugs, COX-2 and EGFR are overexpressed in non-small cell lung cancer., EGFR, like Bcl-2 and p53, was significantly up-regulated in tumors from elderly patients., We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues., Data show that EI-04 as a superior cancer therapeutic in treating EGFR and IGF-1R pathway responsive tumors., study identified a cooperative effect of loss of BRCA1 with gain of EGFR expression that leads to increased clonal proliferation of mammary epithelial cells and may render these cells vulnerable to malignant transformation, Studies indicate that Assessment of EGFR status by gene copy number and/or mutation analysis has proven to be predictive of response to anti-TKI inhibitors., In patients receiving Erlotinib in combination with Gemcitabine and Capecitabine as a first-line therapy in metastatic/recurrent pancreatic cancer, EGFR expression was associated with shorter overall survival, Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17., Allele-specific qPCR assays for the most frequent activating mutations in EGFR, KRAS, BRAF and PIK3CA in tumor-positive fine needle cytological aspirates were compared against histological material of primary tumors., EGFR mutations were associated with pulmonary pleomorphic carcinoma., constitutively active H-Ras can confer resistance to anti-EGFR therapy in cancer cells, Results suggest that EGFR mutation is not a prognostic marker in Korean patients with advanced lung adenocarcinoma who had not been treated with EGFR tyrosine kinase inhibitors., these results suggest that a considerable proportion of NSCLC in Chinese population showed discrepancy in KRAS and EGFR mutation status between primary tumors and corresponding metastases., demonstrate that cells transfected with SSTR1 or SSTR1/5 negatively regulates EGF mediated effects attributed to the inhibition of EGFR phosphorylation., Lung cancer in never-smoker appears to be a distinct entity from lung cancer in smoker, with specific molecular characteristics such as frequent EGFR mutations., Combined targeting of c-Met and EGFR leads to increased xenograft antitumor activity, The density of microvascularization was assessed using CD34 monoclonal antibody (hot spot technique), the expression of angiogenic factors VEGFR, EGFR and COX-2 were determined in tumor biopsies by specific immunohistochemistry techniques, Conserved intramolecular non-covalent bond networks are identified across ErbB family kinase EGFR that emerge from sequence homology and lead to conserved dynamic characteristics as well as function., data identify NF-kappaB as a potential companion drug target, together with EGFR, in EGFR-mutant lung cancers and provide insight into the mechanisms by which tumour cells escape from oncogene dependence, Gastric carcinoma of the mucinous adenocarcinoma type collected from older male patients may harbour EGFR mutations., Epidermal growth factor receptor overexpression is associated with malignant pleural mesothelioma, EGFR related mutational status and association to clinical outcome in metastatic colorectal cancer., Data show that EGF mutants with faster kinetic on-rates stimulate increased EGFR activation compared to wild-type EGF., The aim of this study was to elucidate the interaction between EGFR ligands and their signaling pathway and MMP1 expression which might be closely related with breast cancer pathogenesis., In patients, with chronic hepatitis C associated the EGF genotype G/G with increased risk for hepatocellular carcinoma; differences in its frequency among black and white subjects might account for differences in HCC incidence between these groups., Hogbarn dust (HDE) activates EGFRs and their downstream signaling, and EGFR activation is required for some but not all airway epithelial cell responses to HDE., genetic polymorphism is assopciated with recurrent non-small-cell lung cancer in patients receiving gefitinib, our study has revealed an asymmetric conformation of human EGFR in contact with the plasma membrane that shares features with that in Drosophila EGFR, suggesting the structural basis for negative cooperativity is conserved from invertebrates to humans., The mRNA levels for EGFR and its associated ligands, including HB-EGF, were induced several fold in PANC-1 and HCT116 cells in response to AM251., suppression of CXCR4 inhibits EGFRvIII-mediated breast cancer cell invasion and proliferation, HA facilitates TGF-beta1-dependent fibroblast proliferation through promoting interaction between CD44 and EGFR, which then promotes specific MAPK/ERK activation, inducing cellular proliferation., EGFR was found to be expressed in 61.8% of brain gliomas, with strongly positive expression in 12.2% of them, study demonstrated existing EGFR mutations in a study of 70 triple negative breast cancers in a Singapore population (8 of 70 samples); mutations included EGFR exon 19 deletions (4 of 70 samples ) and EGFR exon 21 substitutions (3 of 70 samples), Increased EGFR gene copy number is associated with head and neck squamous cell carcinoma., The EGFR was efficiently dephosphorylated in treated patients as compared to a control cohort of 12 patients, TFF2 is mitogenic in cholangiocarcinoma via EGFR/MAPK activation., C-erbB-2 and EGFR might have a synergetic effect in the development and progress of nasopharyngeal carcinoma. Co-expression closely correlates with cell proliferation status., Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Review., Integration of aCGH and gene expression data identified copy number aberrations and novel genes with prognostic potential in OAC., results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy., EGF receptor tyrosine kinase up-regulates the K(IR) 2.3 channel via phosphorylation of the Y234 residue of the WT protein. This effect may be involved in the endogenous regulation of cellular electrical activity., Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells., PDGFR-beta- and EGFR-immunoreactivity of pulmonary vessels distinguishes pulmonary arterial hypertension patients from controls, analysis of synergistic effects of epidermal growth factor receptor antibodies on unliganded ErbB dimers and oligomers, EGFR and KRAS status should be tested in metastasis regardless of known mutations of the primary tumor., increased EGFR protein levels and gene copy numbers (not gene amplification alone) have prognostic significance in the investigated Hungarian head and neck squamous cell carcinoma patient population., A direct association between EGFR mutations and ER beta expression in lung cancer cell lines is lacking., These data indicate that Neisseria gonorrhoeae modulates the activity and cellular distribution of host EGFR, facilitating their invasion., EGFR mutations and amplifications in 23 adenosquamous carcinomas of lung, EGFR pathway inhibitors block bronchial hyperplasia in an organotypic culture model, data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio, Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma., EGFR mutation is an early event in the pathogenesis of lung adenocarcinoma and may facilitate the tumor into aggressive behavior, Identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. These receptor tyrosine kinases mediate HCV entry by regulating CD81-claudin-1 co-receptor associations and viral glycoprotein-dependent membrane fusion., EGFR mutations in exons 19 (deletion mutation) and 21 (L858R mutation) predict a longer progression-free survival in patients with advanced non-small cell lung cancer., in non-small cell lung cancer (NSCLC), EGFR mutation was independently associated with the female gender, negative expression of progesterone receptor, and negative expression of aromatase, Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells, EGFR gene mutations were detected in 42 cases NSCLC (26.9%). Twenty-three patients with EGFR mutations received gefitinib, with an overall response rate (partial response [PR]) of 54.5% and disease control rate (PR + stable disease) of 86.4%., Repeat numbers of CA SSR1 might not be a useful prognostic factor for oral squamous cell carcinoma in Taiwanese and the status of CA SSR1 of EGFR may be a useful prognostic factor., These studies indicate that TSP1 disrupts the endothelial barrier through EGFR/ErbB2 activation although additional signals are necessary in cells with low receptor expression., a novel variant of EGFR, which lacks the entire exon 4 sequence, is widely expressed in human tumors, and it seems to be associated with tumorigenesis., Data show that IL-8 overexpression is induced by activating mutations of KRAS or EGFR in non-small cell lung cancer (NSCLC) cells., E. coli O157 , KRAS mutation status is a treatment effect modifier for anti-EGFR antibodies in metastatic colorectal cancer, EGFR gain is associated with poor overall survival for lung adenocarcinoma patients and may be used as prognostic marker, Activation of epidermal growth factor receptor promotes squamous carcinoma cell migration and invasion via inducing epithelial mesenchymal transformation-like phenotype change and matrix metallproteinase-9-mediated degradation of E-cadherin, The presence of sensitizing EGFR mutations correlates with radiographic response., Our data suggest EGFR signaling to play a role in cell migration and brain infiltration of adaCP., No evidence of any relationship between EGFR genotypes and tumor regression was found., GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding, Evidence is presented for the nuclear presence of a functional heteromeric complex of epidermal growth factor (EGFR), Src and the Signal Transducer and Activator of Transcription (Stat)3 proteins in pancreatic cancer cells., Germ-line mutations in EGFR are rare but may contribute to oncogenesis., EGFR expression may play a role in breast cancer proliferation, but appears unlikely to modify tumour pathology., Higher dosage of the epidermal growth factor receptor mutant allele is associated with lung adenocarcinoma., our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation., the incidence of EGFR and KRAS mutations in Chinese patients with adenosquamous carcinoma of the lung (ADSQ) were similar to those of Asian patients with adenocarcinoma; EGFR silent mutations accounted for a large proportion in ADSQ, a model in which Usp18 inhibition promotes up-regulation of miR-7, which in turn inhibits EGFR expression and the tumorigenic activity of cancer cells., Mutations in EGFR is associated with drug resistance and epithelial to mesenchymal transition in lung cancer., Report sssociation of rheumatoid arthritis risk with EGFR SNPs in Taiwan's Han Chinese population., The Pulmonary Pathology Working Group of the Austrian Society of Pathology, after intense discussions and in consensus with Oncologists and Pulmonologists, recommends a priori EGFR mutation analysis for all cases of adenocarcinoma., The role of EGFR in the upregulation of inflammatory markers in A549 cells exposed to cadmium is reported., Data suggest that sustained inhibition of both EGFR and ERK1/2 leads to significant protection of the cells from IFNgamma-induced apoptosis, indicating important roles for the EGFR tyrosine kinase and ERK1/2 MAP-kinases in regulating A431 cell death., In patients with surgically resected lung adenocarcinomas, KRAS and EGFR gene mutation status of tumors was not associated with disease-free survival. EGFR gene mutations were linked to favorable overall survival and median survival time after recurrence., epithelial growth factor receptor mutations in cerebrospinal fluid is associated with lung adenocarcinoma suspected of neoplastic meningitis., The incidence of EGFR mutations in Chinese patients with Esophageal Squamous Cell Carcinoma was higher than that of previous reports. EGFR mutations were mainly located in exons 19 and 21., Propose a Systems Biology approach to understand the molecular biology of EGFR and IGF1R pathways in non-small cell lung cancer., summarizes both preclinical and clinical available data regarding EGFR genomic alterations as prognostic and predictive factors, Combined targeting of c-Met and EGFR resulted in an enhanced inhibition of tumor volumes accompanied by a decreased number of proliferating cells and increased apoptosis compared with single agent treatment in vivo., MUC5AC expression is regulated by a bidirectional circuit between Notch and EGFR signaling pathways., EGFR gene alterations are associated with lung cancer., data indicate that EGFR T790M exists in pretreatment non-small cell lung cancer at low levels irrespective of histologic types, findings show VEGFR-2 and VEGFR-3 expression are markers of a poor prognosis in patients with surgically resected colorectal adenocarcinoma, whereas EGFR has a minor influence, the expression and clinical relevance of c-Cbl, Cbl-b and EGFR in non-small cell lung cancer, EGFR mutations were discordant between the primary tumor and the corresponding metastases in non-small cell lung cancer, huEGFRt serves as a highly efficient selection epitope for chimeric antigen receptor(+) T cells, Data show that both EGFR-TKIs increased ATG5 and ATG7 at the mRNA or protein levels (Figure 3), confirming the induction of autophagy by EGFR-TKIs., Decreasing the expression level of EGFR, rather than inhibiting its tyrosine kinase activity, may enhance the efficiency of EGFR- targeted therapy for prostate cancer., study concludes that none of the glioblastomas with a TP53 mutation had the EGFRvIII variant, Regulation of Double Strand Break repair by EGFR involves both the NHEJ and HR pathway, and appears to occur in most tumor cell lines regardless of p53 and K-Ras mutation status., Autocrine activation of epithelial-mesenchymal-transition leading to EMT is associated with a metastatic phenotype and reduced sensitivity of SCCHN cells to single-modality treatment with cetuximab or irradiation., antisense-mediated inhibition of mature miR-7 expression led up-regulation of EGFR and its downstream effectors, and increased radio-resistance of U251 glioma cells., high EGFR protein level may not necessarily indicate Tyr1068 phosphorylation and thereby receptor activation in cervical cancer., Epidermal growth factor receptor mutation is associated with treatment response in non-small cell lung cancer., EGFR mutations are associated with docetaxel response in lung cancer., An evaluation of cytomorphologic features of advanced lung adenocarcinomas that might be associated with EGFR mutational status., pSTAT3 was identified in the BAC component of 88% of the EGFR mutant (n=17) and 82% of the wild-type tumors (n=33)., EGFR and MET coordinate to drive non-small cell lung carcinoma tumorigenesis., Up-regulation of EGFR occurs through direct binding of HOXB7 to the EGFR promoter, enhancing transcriptional activity., Automated EGFR SISH, in combination with KRAS mutation analysis, can be a useful and easily applicable technique in routine diagnostic practise for selecting patients for anti-EGFR therapy., The extremely low incidence of EGFR protein expression and gene amplification in Saudi breast cancer patients as compared to Western populations is most probably ethnically related., Increasing sialylation and fucosylation could attenuate EGFR-mediated invasion of lung cancer cells. However, incorporation of the core fucose by alpha1,6-fucosylatransferase (FUT8) would promote EGFR dimerization and phosphorylation., This reveals that the L834R mutation introduces conformational changes in both states, adjusting the relative stabilities of active and inactive conformations and hence the activation of the EGFR kinase., EGFR mutation is associated with nonsmall cell lung cancer., analysis of epidermal growth factor receptor (EGFR) in lung cancer, While no significant difference in survival was observed between EGFR exon 19 deletion and L858R mutation, EGFR exon 19 deletion was predictive of longer PFS following EGFR TKI treatment in patients with advanced NSCLC., EGFR mutations are associated with response to therapy in lung adenocarcinoma., Low baseline sEGFR is associated with reduced survival in advanced non-small-cell lung cancer, EGFR mutations were discordant between primary tumors and corresponding metastases in a significant portion of lung adenocarcinomas., Results suggest that the heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma., BCRP/ABCG2 expression may be a predictor for poor efficacy of gefitinib treatment, and targeting BCRP/ABCG2 may broaden the use of gefitinib in patients with wtEGFR., Progression-free survival time of patients with both EGFR mutations and MET FISH positive defined by the Cappuzzo scoring system was significantly shorter than with EGFR mutations alone., Data suggest that drug-sensitive and drug-resistant EGFR-mutant cells exhibit differential growth kinetics, with the drug-resistant cells showing slower growth., Data indicate that neither total nor full-length EGFR protein level, or autophosphorylation status, showed prognostic significance., results indicate that downregulated Mig-6 in NSCLC tissues may serve as a new marker that can predict the activation of EGFR signaling pathway, DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib., These results suggest that cancer cells in the PNI areas could acquired a growth advantage that could be triggered by the growth factor receptors EGFR and CD74., SMURF2-mediated protective ubiquitination of EGFR may be responsible for EGFR overexpression in certain tumors., Data show that mandatory overexpression of hGSTA4 by transient transfection in KYSE30 cells and attenuation of HNE-induced EGFR phosphorylation., We propose paxillin as a novel cellular target for converging H. pylori-induced EGFR, FAK/Src, and PI3K/Akt signaling to regulate cytoskeletal reorganization and IL-8 production in part, thus contributing to the H. pylori-induced diseases., Nuclear phosphorylated EGFR upregulates iNOS expression and EGFR nuclear import is associated with gallbladder carcinoma, epidermal growth factor receptor (EGFR) was elevated in breast cancer cases versus controls, the structural, molecular, and clinical implications of EGFR exon 20 insertions in non-small-cell lung cancer (Review), time course experiments with different kinase inhibitors demonstrated that GPR109A induced ERK1/2 activation via the matrix metalloproteinase/epidermal growth factor receptor transactivation pathway at both early and later time points, both EGFR and HRAS mutations are rare events in the carcinogenesis of cutaneous squamous cell carcinoma, and therefore, only a small subgroup of patients will benefit from the screening for mutations, The correlation between expression of pEGFR and pAKT is indicative of activation of the PI3-K/AKT pathway through phosphorylation of EGFR in head and neck squamous cell carcinoma., This nomogram could be highly useful to predict the presence of EGFR mutations in lung adenocarcinoma in non-Asian patients when mutational profiling is not available or possible., deletion of NFKBIA and amplification of EGFR show a pattern of mutual exclusivity in glioblastoma multiforme[review], These findings suggest that 25-methoxyhispidol A-mediated inhibitory activity of human breast cancer cell growth might be related with the cell cycle arrest and modulation of signal transduction pathways., Inhibition of EGFR and Her2 phosphorylation by Lapatinib is shown to be associated with the inhibition of Akt phosphorylation., Results of this study strongly support the potential of KL-6 as a diagnostic biomarker for life-threatening EGFR tyrosine kinase inhibitor induced interstitial lung disease., EGFR was present in the parabasal layers in 27 acquired middle ear cholesteatoma cases and EGFR expression was extended to all layers of the matrix in 17 cases. There were no significant differences in age-related variances in EGFR expression., EGFR is an important factor enhancing the malignancy of MDR breast cancer cells, partially, inducing MDR., EGFR-activating mutations are associated with treatment responses of lung adenocarcinoma ., The EGFR mutation occurred more frequently in male patients with ground grass opacity,GGO than in those without GGO., EGFR and mTOR signaling pathways are deregulated in ES., The ultrastructure of EGFR is examined., Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling., results provide a detailed and quantitative demonstration of how regulators and scaffolds can collaborate to fine-tune the ligand-dependent sensitivity of EGFR endocytosis and ERK activation, Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression in association with EGFR gene mutation., Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway., EGFR protein overexpression is closely related to EGFR copy number in oral cavity squamous cell carcinoma, distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S), It was shown that lysophosphatidic acid 5 receptor transactivated the epidermal growth factor receptor and that inhibition of epidermal growth factor receptor blocked lysophosphatidic acid 5 receptor-dependent activation of NHE3., Prospective EGFR immunohistochemistry analysis in an adult cohort comprising 750 infiltrative gliomas, is described., EGFR mutations are associated with the response to therapy in non-small cell lung cancer., our results indicate that IDHR132H mutation correlates significantly with p53 and inversely with EGFR mutations, EGFR mutation is associated with erlotinib accumulation in brain metastases from non-small cell lung cancer., Rho-kinase signaling pathway plays a suppressive role in the intracellular vesicle trafficking of pEGFR via the endocytic pathway., EGFR copy number status is a more reliable indicator than protein overexpression of the survival rate in oral tongue squamous cell carcinoma., The EGFR unprecedented and activated conformation could be sustained by simultaneous alterations in membrane structure under oxidative stress., A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway., Data show that of the six patients harboring complex EGFR mutations with classical mutation patterns, five had positive IHC staining., Data indicate that curcumin potentiates antitumor activity of gefitinib through inhibition of proliferation, EGFR phosphorylation, and altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell., EGFR mutant in non-small cell lung cancer is not associated with erlotinib resistance for Central Nervous System metastases., EGFR mutations are associated with treatment response in lung cancer., the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients, High-level EGFR immunohistochemical expression correlated with and predicted EGFR amplification in basal-like carcinoma of the breast., Data show that uPAR and its crosstalk pathways with EGFRvIII emerge as logical targets for therapeutics development in GBM., Genotypes with the variant allele of EGFR R521K SNP confer a risk reduction to develop colorectal cancer., Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors, increasing EGFR levels during head and neck carcinogenesis can be interpreted as a physiological response to permanent carcinogen impact on the mucosa., Hyperactive EGFR signaling through Stat3 and the Jak-Stat3 activity together promote ovarian cancer progression to cisplatin resistance, Inhibition of EGFR significantly suppressed the ability of overexpressed HER2 to induce enhanced signaling and cell transformation, suggesting that HER2 requires the EGFR to maximize its signaling and transformation potency, EGFR-activating mutations are associated with treatment response in non-small cell lung cancer., EGFR mutation-positive status can predict better response to combined chemoradiotherapy, a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells, Results suggest that Rab7 is likely involved in protecting EGFR and Her2 from being degraded by the proteosome and in maintaining optimal tumor cell Akt survival signal., Adenocarcinoma is the most frequent EGFR mutation pathologic type in lung cancer., Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling., EGFR overexpression is associated with skin lesions., Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of epidermal growth factor receptor, Validated liquid-based cytology for EGFR and KRAS gene mutations and set appropriate laser capture microdissection and direct sequencing benchmarks., Findings reveal that an exogenous EGF stimulation may enhance HPV-related cervical cancer cell proliferation by activating EGFR and cyclin D1 that is independent of COX-2 levels., EGFR immunohistochemistry is not a suitable criterion for reliably selecting patients for anti-EGFR treatment. EGFR in situ hybridization may be reliably performed with high accuracy, allowing treatment decisions for lung cancer., Data show that Down-regulation of c-Cbl in VHL-deficient ccRCC cells revealed that the c-Cbl and pVHL collaborated to down-regulate the activated EGFR., EGFR mutations are associated with non-small cell lung cancer., The prognostic significance of the mRNA expression of nine genes in the EGFR and NF-kappaB pathways, was investigated., explored the tumorigenic potential of the EGFR mutations that we had previously identified and their sensitivity to two different EGFR tyrosine kinase inhibitors, Findings implicate EGFR -191C/A and the (CA)(n) repeat polymorphisms as risk factors for gliomas, and suggest -191C/A as a prognostic marker in glioblastoma., Suppressing expression of EGFR inhibited cell proliferation., downregulation of HIF-1 through EGFR signaling seems to be required for the induction of a positive response to EGFR-targeted therapies in TNBC, EGFR expressed on head and neck squamous cell carcinoma cells induces a specific immune response in vivo., EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction., Data indicate that circulating tumor DNA could potentially be used as an alternative method for EGFR mutation detection., Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling, Inhibition of the EGFR expression prevents immortalization of human cervical cells by Human Papillomavirus type 16., both primary and lymph-node metastases have relatively consistent EGFR mutations and EGFR mutations are not relevant to changes in c-Met gene copy number., In vitro studies demonstrate that EGFR activation is associated with induction of a variety of proinflammatory molecules (e.g., IL6, IL8, ICAM1), and this effect is reversed upon administration of EGFR-specific inhibitors., Epidermal growth factor receptor gene mutations are associated with treatment response in advanced non-small cell lung cancer, The identification of an in-frame splice variant of EGFR expands the mechanisms by which EGFR contributes to oncogenesis and represents the first link between two areas of cancer cell biology, High Expression of EGFR resulting in phosphorylated ERK and phosphorylated MEK are associated with colonic neoplasms of familial adenomatous polyposis., The status of the O-glycans attached to the EGFR was altered by GALNT2, changing EGFR responses after EGF binding., Data show that EGFR expression was significantly higher in responders versus nonresponders to gefitinib., mechanisms of allosteric activation may have universally evolved in the ABL and EGFR regulatory complexes as a product of a functional cross-talk between the organizing alphaF-helix and conformationally adaptive alphaI-helix and alphaC-helix, The clinical evidence concerning the use of monoclonal antibodies targeting the EGFR in the setting of advanced colorectal cancer., show that the GBM-derived epidermal growth factor receptor (EGFR) CTD deletion mutants are able to induce cellular transformation in vitro and in vivo in the absence of ligand and receptor autophosphorylation., Concurrent exon 19 EGFR mutation and ALK rearrangement is associated with response to erlotinib in lung adenocarcinoma., The epidermal growth factor receptor (EGFR) is over-expressed in 40-80% of patients with non-small-cell lung cancer (NSCLC)., EGFR1 expression was significantly upregulated in poorly differentiated and anaplastic thyroid carcinomas, whereas it was absent or faint in normal thyroid gland tissue and in differentiated thyroid papillary carcinomas., There was no significant difference in EGFR mutation frequency between the primary and metastatic nonsmall cell lung tumors., EGF receptor ubiquitination and recruitment of ESCRT protein complexes are required for trafficking-mediated downregulation of receptor activity., These results implicate both signal propagation and the cortical cytoskeleton in reduced mobility of signaling-competent erbB1 dimers., TIEG1 inhibits breast cancer cell invasion by inhibition of the EGFR signaling pathway., EGFR sequences showed somatic missense mutations in exons 18 and 20 at a frequency of 2.1% and 0.4% and Somatic SNPs in exons 20 and 21 at a frequency of about 3.1% and 0.4% respectively., As the dose of gefitinib increased, a gradual decrease in EGFR tyrosine phosphorylation was detected in pediatric glioblastoma and neuroblastoma cells., Met and EGFR to be released from lipid rafts, thus leading to their activation in a ligand-independent manner., EGFR signalling in neoplastic stromal cells may contribute to disease progression through promoting stromal cell proliferation and osteoclastogenesis in giant cell tumour of bone, Routine epidermal growth factor receptor (EGFR) screening using diagnostic samples is fast and feasible even on samples with poor cellularity and DNA content., the activation of PI3K and MEK pathways is not the only mechanism of EGFR-resistance, These findings suggest that APPL1 is required for EGFR signaling by regulation of EGFR stabilities through inhibition of Rab5., Review, Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors., We sought to study the pattern of expression of COX-2 and epidermal growth factor receptor, and their association with microvascular density, clinicopathological features, and survival in Arab Omani patients with gastric cancer., The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status in colorectal carcinomas, p53 homolog DeltaNp63alpha enhances the oncogenic potential of pancreatic cancer cells through trans-activation of EGFR and 14-3-3sigma., High EGFR expression is a tumour biomarker that can predict survival benefit from the addition of cetuximab to first-line chemotherapy in patients with advanced non-small lung cancer., epidermal growth factor receptor (EGFR) activation induces translocation of PKM2, but not PKM1, into the nucleus, where K433 of PKM2 binds to c-Src-phosphorylated Y333 of beta-catenin, These results demonstrate that hEAG1 channel activity is regulated by EGFR kinase at the tyrosine residues Tyr90, Try344, and Try485., The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding., Interferon-gamma alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells, EGFR expression in tissue microarrays of 240 breast cancer patients was detected by quantum dot-immunohistochemistry and spectral analysis. The prognostic value of EGFR immunofluorescence area for five-year recurrence-free survival was investigated., Persistent activation of signaling by the AKT-survivin pathway induced by PTEN loss underlies a mechanism of resistance to erlotinib-induced apoptosis in EGFR mutation-positive non-small cell lung cancer., analysis of radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr, triple-negative cases had a worse prognosis for relapse and death, compared with cases with EGFR, KRAS, or ALK mutations or group B triple-negative cases, a tight cooperation between the EGF/EGFR and mPGES-1 leads to a significant tumorigenic gain in epithelial cells, Activity of EGFR and AKT was increased in AZD6244-resistant cells., high glucose promotes pancreatic cancer cell proliferation by both the induction of EGF expression and transactivation of EGFR, Activation of EGFR connected to AKT and ERK signaling pathways may induce anti-apoptosis and promote cell proliferation., Data show that elevated levels of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1a)-247R-expressing cells are responsible for EGF receptor (EGFR) transactivation., FISH-positive EGFR expression is associated with gender and smoking status, but not correlated with the expression of ERCC1 and BRCA1 proteins in non-small cell lung cancer., novel 5-alkynyl-4-anilinopyrimidines are potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases, Cathepsin S plays an important role in the regulation of cell autophagy through interference with the EGFR-ERK/MAPK-signaling pathway., Two oncogenic mutants of EGFR are fully active independently of EGF and highly resistant to the therapeutic and endogenous inhibitors cetuximab, lapatinib and MIG6., EGFR-mediated apoptosis is initiated by the activated EGFR from the limiting membrane of the endosome, Results suggest that FKBP12 forms an endogenous inhibitor of EGFR phosphorylation directly involved in control of cellular EGFR activity (as in carcinoma)., 2 of 40 small-cell lung cancer cases had mutations in EGFR exon 19, LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis, Median progression-free survival with second-line EGFR TKIs is significantly longer than second-line pemetrexed., Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells., Protein expression of VEGF, EGFR and MMP-9 is elevated in non-small cell lung carcinomas, correlating with progression., EGFR copy number increases detectable in vulvar carcinomas show relationships with advanced tumour stages and the development of lymph node metastases., Small cell lung cancer with an epidermal growth factor receptor mutation is associated with primary gefitinib-resistant adenocarcinoma of the lung, Studies indicate that tumor heterogeneity and probably also previous systemic treatment may be an obstacle for correct interpretation of EGFR status in non-small cell lung cancer (NSCLC)., Molecular diagnosis of EGFR gene copy number by FISH varied largely among pathology centres, with fluctuations covering the whole range of proposed cut-offs of predictive usefulness from literature., EGFR plays a critical role in mediating nontypeable Haemophilus influenzae -induced NF-kappaB activation and inflammation., EGFR whole gene amplification is frequently observed in patients with breast cancer., The EGFR mutation rate in pleural metastatic tissues of lung adenocarcinoma acquired through video-assisted thoracoscopic surgery was higher compared to that in surgical resection specimens., Data indicate that PIK3CA mutations occur in lung adenocarcinomas, usually concurrently with EGFR, KRAS, and anaplastic lymphoma kinase (ALK)., multiple receptor tyrosine kinases are amplified in a subset of glioblastoma subclones, epidermal growth factor receptor, MET and platelet-derived growth factor receptor alpha, Expression of the constitutively active mutant epidermal growth factor receptor is associated with significantly higher expression of interleukin-8 in human glioma specimens and glioma stem cells., With increasing concentration of cucurmosin, the expression of EGFR at the protein level was decreased., and increased gene copy number of EGFR and HER2 characterize high-grade malignancy with unfavorable prognosis in salivary gland cancer, EGFR mutation status is associated with lung adenocarcinoma., these results are the first to identify EGFR and MET-receptor-regulated miRNAs representing oncogenic signaling networks in NSCLCs., Ca(2+)/CaM regulates the EGFR activity by directly interacting with the CaM-BD of the receptor located at its cytosolic juxtamembrane region., Report validity EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection., ligand-stimulated EGFR activated NFkappaB-dependent transcription and induced secretion of IL-6 and plasminogen activator inhibitor., Oxidation of the EGFR active site modulates kinase activity, aspirin (1) reduces cell surface expression of EGFR and (2) accumulates endocytosed-EGFR and -TfnR in the early/sorting endosome, EGFR mutation is associated with response to therapy in non-small-cell lung cancer., Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma., establish GBP1 as a previously unknown link between EGFR activity and MMP1 expression and nominate it as a novel potential therapeutic target for inhibiting GBM invasion., EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib., EGFR mutations, especially exon 19 deletions are associated with pulmonary tuberculosis in patients with adenocarcinoma of the lungs., A considerable proportion of NSCLC in Chinese patients showed discrepancy in KRAS and EGFR mutation status between primary tumors and corresponding metastases., the existence of sEGFR isoforms specifically produced by NSCLC tumor cells which could represent a new potential biomarker for diagnosis and therapy of lung tumors., Report mutations in KRAS, EGFR, and BRAF in cholangiocarcinoma and identify therapeutic targets for tyrosine kinase inhibitors., Overexpression of EGFR promoted the multidrug resistance phenotypes in breast cancer cells via accelerating the G1/S phase transition., identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR signaling, study has shown that EGFR exon 19 insertions are a new family of sensitizing EGFR mutations in lung adenocarcinoma, This study highlights variations in the prevalence of EGFR mutations in Triple-negative breast cancers (TNBCs)., These experiments define a novel biological function of PIM-1 as a co-regulator of EGFR signaling., Inhibition of survival signals and concomitant release of apoptotic potential jointly contribute to the tumor cell death following the inhibition of addicted oncogene in EGFR addicted cancers., Human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue., OPRM1 and EGFR were associated with variation in skin pigmentation in Indigenous Americans and Europeans for the first time., HER2 seems to be a valid therapeutic target of EGFR inhibitors in HER2-addicted lung carcinomas, IDH1 mutation may correlate with the benefit from VEGF(R)- versus EGFR-targeted therapy at the time of recurrence in glioma patients, ADAM17 contributes to androgen-independent prostate cancer cell invasion by shedding of EGFR ligand TGF-alpha, which subsequently activates the EGFR-MEK-ERK signaling pathway, leading finally to overexpression of MMP-2 and MMP-9., Protein interactions with EGFR can have different characteristics depending on the hosting cell line., The assessment of p16, EGFR, and COX-2 allows to an integrative approach for the progression of squamous intraepithelial lesion, associated or not with the human papilloma virus infection., EGFR and K-ras mutations frequently occur randomly in multifocal lung adenocarcinomas, Suggest that the continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib after progressive disease enhances the antitumor activity of chemotherapy., High serum EGFR is associated with virus infection in liver carcinogenesis., L858R/T790M mutant epidermal growth factor receptor is associated with lung cancer., High EGFR is associated with tongue cancer., EGFR protein overexpression in gastrointestinal cancers is common but FISH assessment showed that EGFR gene amplification is rare. A statistically significant association was found between EGFR protein overexpression & chromosome 7 polysomy., The pooled analysis shows that the incidence of EGFR mutations in NSCLC differs according to cigarette-smoking history. The odds ratio (OR) for the EGFR mutation in non-smokers relative to smokers was 4.829., The observed relationships between EGFR and pEGFR indicate that high-throughput pEGFR/EGFR analyses merit further investigations and consideration for routine use in patient samples., Our findings suggest that EGFR/KRAS mutations do not occur in pure pulmonary squamous cell carcinoma (SQCC)., breast tumor kinase (Brk)/protein-tyrosine kinase 6 (PTK6), a nonreceptor protein-tyrosine kinase highly expressed in most human breast tumors, interacted with EGFR and sustained ligand-induced EGFR signaling., silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling, These data suggest differences in the dimerization-blocking efficacy of EGFR monoclonal antibodies as mutant EGFR dimer configurations prevalent in glioblastoma multiforme., EGFR216, EGFR191, ABCG2, and AKT1 polymorphism is not associated with erlotinib response in non-small cell lung cancer., High incidence of EGFR mutations is associated with smoking and lung adenocarcinoma histology, Results show that ponatinib is a potent pan-FGFR inhibitor and strongly support the investigation of ponatinib in patients with FGFR-driven cancers., These findings demonstrate a key role for ErbB1 in adipogenesis and suggest that lower ErbB1 protein abundance may lead to adipose tissue dysfunction., Analysis of the relationship between EGFRvIII expression and overall survival in 73 patients with newly diagnosed glioblastoma., human airway epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signaling and bacterial adhesion., epidermal growth factor receptor tyrosine phosphorylates MUC1, leading to an increase in its association with TLR5, thereby competitively and reversibly inhibiting recruitment of MyD88 to TLR5 and downstream signaling events., Lack of EGFR mutations is associated with gefitinib treatment response in adenocarcinoma of esophagogastric junction., An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression., Mutations in RAS, particularly HRAS, are frequent in cutaneous squamous-cell carcinomas and keratoacanthomas that develop in patients treated with vemurafenib., Binding of EGF to its receptor is positively linked with dimer assembly, but shows negative co-operativity within the dimer., in HER1, the extracellular region asymmetry requires interactions with the plasma membrane., I review the studies that have highlighted the role of the JXM domain in EGFR activation. [Review], Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase., EGFR expression is a poor prognostic factor for survival in patients with pancreatic cancer., EGFR and MGMT promoter hypermethylations are early events in the clonal evolution of gliomas and this gene inactivation has proved to be stable even in tumour recurrence., suggest that mutations of EGFR good markers of different aetiologies and histopathological forms of lung cancers but have little prognostic value, Suppression of EGFR expression can significantly inhibit epithelial-mesenchymal transition of pancreatic cancer PANC-1 cells. The mechanism may be related with the down-regulation of the expression of transcription factors snail and slug., Results suggest that TWIST1 is an important driver of epithelial to mesenchymal transition in EGFR mutated cells and could be a potential marker in clinics to predict outcome in patients with EGFR mutated tumors, The reduced expression of E-cadherin and beta-catenin and EGFR over expression seems to be correlated with tumor differentiation and tumor progression than tumor invasion and tumor proliferation., in patients with nonsmall cell lung cancer, ALK gene rearrangement was significantly associated with pericardial disease and pleural disease; patients with ALK gene rearrangements and patients with EGFR mutations were predisposed to liver metastasis compared to triple negative cohort, Support the rationale for routine baseline tissue-based assessment of EGFR mutations in patients with NSCLC and for treatment of mutation-positive patients with EGFR tyrosine-kinase inhibitors., The EGFR-R497K polymorphism is a potential predictor for overall survival in HNSCC patients., results indicate that TGFbeta1- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies, Hedgehog-EGFR regulated genes, SOX2, SOX9, JUN, CXCR4 and FGF19, are required for tumor growth., overexpression of wild-type as well as truncated-mutant Ankrd 13A, 13B and 13D proteins strongly inhibited rapid endocytosis of ubiquitinated EGFR from the surface in EGF-treated cells, statistically significant relation was found between local recurrence of ameloblastoma and expression of EGFR, Regulation of EGFR expression is critical in lung development. [review], two most commonly amplified receptor tyrosine kinase genes, EGFR and PDGFRA, were found to be present in variable proportions across the tumors, with one or the other gene predominating in certain areas of the same specimen., Dephosphorylation of AKT in association with EGFR mutation is a candidate marker for sensitivity to cetuximab in lung cancer., a novel role for CDCP1 in EGF/EGFR-induced cell migration and indicate that targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling, EGFR ligand strongly induces EGR1 and upregulates the production of growth factors and cytokines in mesenchymal stem cells., Data show that cell lines with high-level EGFR amplification/EGFRvIII expression formed highly aggressive tumors in nude mice., Data indicate that 266 (76.2%) tumors harbored EGFR mutations, 16 (4.6%) HER2 mutations, 15 (4.3%) EML4-ALK fusions, 7 (2.0%) KRAS mutations, and 2 (0.6%) BRAF mutations., the R521K polymorphism of epidermal growth factor receptor, by reducing its activation and a consequential downregulation of its target genes, including VEGF, could be a key determinant of an increased response to cetuximab-based chemotherapy, EGFR mutations are more frequent in female patients and patients with adenocarcinoma NSCLC, involving mainly exon 19 and 21., There is a higher EGFR mutation rate in females, pateints less than 60 years old, non-smokers, and adenocarcinoma among Chinese patients with NSCLC., The incidence of EGFR mutations in non-small cell lung cancer is higher in Chinese patients, especially in non-smoking female patients with adenocarcinoma., In patients with non-small cell lung cancers, EGFR gene mutation rates in males were significantly higher than in females, and higher in non-smokers than in smokers., EGFR gene mutations occur more frequently in females, non-smokers and patients with adenocarcinoma. The presence of EGFR amplification appears unrelated to age, gender, histopathological types of lung cancer and subtypes of adenocarcinoma., EGFR mutations occur frequently in females, non-smokers and adenocarcinomas, bronchioloalveolar carcinomas, and adenosquamous carcinomas in patients with non-small cell lung cancer. The patients with EGFR mutations have better prognoses., EGFRvIII, a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in human glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Dock180, a guanine nucleotide exchange factor for Rac1, PDGFRA-amplified Glioblastoma were found to have amplification of EGFR or the hepatocyte growth factor receptor gene (MET) as well., The expression of EGFR was associated with differentiation, clinical stage, and lymph node metastasis, but was not associated with gender, age and histological types of lung cancer., These results suggest a possible role of eosinophils in regulating erbB1 and thus in regulating mucosal hypertrophy in chronic hypertrophic rhinitis., Identification and validation of three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer., non small cell lung cancer brain metastases harboring the exon 19 deletion mutation in the EGFR were smaller, more numerous and less edematous, feedback down-regulation of LRRK1 kinase activity by EGFR plays an important role in the appropriate endosomal trafficking of EGFR, EGFR gene mutation and gene high copy number are more common in Chinese non-small cell lung cancer patients with adenocarcinomas, advanced stage, non-smokers and females., Plasma EGFR mutations in the Chinese patients with advanced NSCLC is not a predictor for the response to first-line chemotherapy, but an independent prognostic factor indicating longer survival., c-Met, epidermal growth factor receptor, and insulin-like growth factor-1 receptor are important for growth in uveal melanoma and independently contribute to migration and metastatic potential, Suggest that the enhanced S1P3-EGFR signaling axis may contribute to the tumorigenesis or progression of lung adenocarcinomas., analyzed the effect of human umbilical cord blood stem cells on the inhibition of EGFR expression and EGFR signaling in glioma cells and xenografts, results provide a structural basis for the altered drug sensitivities caused by distinct NSCLC-associated EGFR mutations, PIKE mediates EGFR-dependent squamous cell carcinoma proliferation., two independent head and neck squamous cell carcinoma cohorts treated with or without cetuximab, tumor EGFR levels were indicative of survival; tumor EGFR PY1068 levels provided prognostic information independent of total EGFR, The mutation status of both EGFR and K-Ras could be a predictive marker of response to IGF-1R TKIs. Also, MEK antagonism can abrogate primary resistance of NSCLC cells to IGF-1R TKIs., analysis of expression of EGFR, pAkt, NF-kappaB and MIC-1 in prostate cancer stem cells and their progenies, EGFR plays critical roles in the survival, maintenance, and function of cancer stem cells, EGFR mutations were present rarely in studied cohort of samples with breast cancer, EGFR was highly expressed and activated in the synovium of patients with rheumatoid arthritis. These findings suggest that EGFR plays a central role in the pathogenesis of RA, EGFR overexpression relates to triple negative profile (ER-/PR-/HER2-) and poor prognosis in breast cancer patients in Tunisia, The close relationship between EGFR and progranulin/VEGF/CD105 expression may partly play a role in high angiogenesis levels in the pN(-) TNBC subtype., EGF-mediated CYR61 upregulation in HES cells involves STAT3 and is counter-regulated by the EGFR/MAPK/ERK pathway., we found EGFR protein expression in 74% of urothelial carcinomas, but we failed to detect EGFR mutations at exons 19 to 21., first evidence provided that miR-133 may target EGFR, EGFR mutations is associated with response to therapy with advanced non-small-cell lung cancer., CAV1 is a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor., EGFR missense mutations were detected in some Japanese cases of malignant pleural and peritoneal mesothelioma., Report efficacy of dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib in colorectal cancer., EGFR copy number may be useful biomolecular marker to differentiate potentially malignant oral disorders from OSCC. EGFR was higher in nonhomogeneous leukoplakias and in advanced stages of OSCC., The independent value of simultaneous membrane + cytoplasmic EGFR cell location and p53 overexpression on survival even in early stages of oral squamous cell carcinoma suggests that these markers may identify high-risk subgroups., EGFR somatic mutations are rare in pancreatobiliary malignancies., Data indicate that TaqMan(R) Mutation Detection assay is an important technology to consider in the field of mutation detection for KRAS, BRAF and EGFR point mutation screening., these findings suggest that miR-542-5p may act as an important modulator of EGFR-mediated oncogenesis, with potential applications as a novel therapeutic target in lung cancer., sequencing of the EGFR TK domain, using 14 mesothelioma cell lines and 33 patient samples, did not reveal any EGFR sensitizing mutations; data show that patients with peritoneal mesothelioma do not harbor somatic mutations in the EGFR TK domain that would make them sensitive to EGFR tyrosione kinase inhibitors, Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels., EGFR exon 19, 20 and 21 mutations were higher in females compared to males and higher in adenocarcinomas compared to other forms of lung cancers, our findings demonstrate that Yes and Lyn phosphorylate EGFR at Y1101, which influences EGFR nuclear translocation in this model of cetuximab resistance., Studies indicate that EGFR signaling in EGFR-mutant lung cancer and hepatocyte growth factor (HGF) ligand-triggered bypass signals (HGF-Met and EGFR ligands-EGFR) must be simultaneously blocked to avoid the resistance., C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR signaling., by promoting EGFR internalization, reggie-1 restricts EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate adherens junction formation, Both higher EGFR positive rate and more intense EGFR expression were significantly associated with well differentiated subtype of squamous cell carcinoma, The protein overexpression of EGFR was not related to a gene copy number gain in malig-nant peritoneal and pleural mesothelioma., Results identify a link between the p14(ARF) and EGFR pathways and suggest that EGFR L858R counteracts the pro-apoptotic function of p14(ARF) by downregulating its expression to promote carcinogenesis in the lung., EGF, induced Ca(2+) release from the endoplasmic reticulum and Ca(2+) entry through TRPC1. Ca(2+) entry through TRPC1 conversely activated EGFR, suggesting that TRPC1 is a component of a Ca(2+)-dependent amplification of EGF-dependent cell proliferation., Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2., The EGFR gene was highly mutated and mainly L858R substitutions occurred as well as insertions and deletions in lung adenocarcinomas from a Chiba Prefecture, Japan cohort., Increasing knowledge of EGFR biology is driving more targeted or alternative approaches to cancer therapies., Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer., These results suggest that glioblastomas with EGFR amplification are a heterogenous group of tumors and that behavior might differ according to the degree of amplification, Results suggest that the efficacy of anti-EGFR drugs in triple negative breast carcinomas with basal like features could be impaired by frequent alterations in the PI3K/PTEN., the protein expression of EGFR had an impact on prognosis in patients with CCRCC, while an increased copy number of chromosome 7 could be the possible reason for EGFR protein overexpression in the absence of gene amplification., endothelin A receptor and epidermal growth factor receptor signaling converge on beta-catenin to promote ovarian cancer metastasis, EGFR gene amplification and EGFR-activating mutations might not be the mechanisms leading to the constitutive activation of EGFR in triple-negative breast cancer., Protein overexpression and/or increased gene copy number of EGFR is common in esophageal squamous cell carcinomas., This study showed an association between vascular-poor area of primary lung adenocarcinomas and EGFR status, results suggest that oncolytic adenovirus induces autophagic cell death through an E2F1-miR-7-EGFR pathway in human cancer cells, providing a novel insight into the molecular mechanism of an anticancer virotherapy, Epidermal growth factor receptor variant III expression is associated with glioblastoma., Chromatin immunoprecipitation (ChIP) and promoter analysis revealed that the EGFR promoter gets occupied by transcriptionally active beta-catenin when elevated in GSK3beta-inactivated cells, EGFR is highly expressed in laryngeal cancer tissue, and relates with the tissue differentiation of laryngeal cancer., The current results indicated that EGFR plays more important roles in cell migration and invasion to the brain than in cell proliferation progression on 231-BR cells., Ligation of M3R with CCh transactivated EGFR., Taken together, NOK has a strong tendency towards forming aggregates, which may have physiological implications and provide the first evidence that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR., lung cancer patients with EGFR-mutations had longer PFS with taxane than gemcitabine when receiving a platinum-based doublet regimen., Results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking., an EGFR mutation may have a role in nonsmall cell lung cancer presenting with miliary intrapulmonary carcinomatosis, RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations., Effusion immunocytochemistry could be introduced into clinical practice to identify more NSCLC patients likely to have benefit from first-line TKI treatment, especially for those without adequate tissue for molecular-based EGFR analysis., Overexpression of Rab21 attenuated EGF-mediated mitogen-activated protein kinase (MAPK) signaling by inducing EGFR degradation., Results indicate that epidermal growth factor receptor (EGFR) L861Q mutation is a frequent EGFR mutation in pulmonary mucoepidermoid carcinoma (PMEC)., The aim of the present study was to determine the frequency of EGFR and KRAS mutations in non-small cell lung cancer in the West European Dutch population., Report associations between EGF and EGFR gene polymorphisms and prognosis for Chinese Han gastric cancer patients., Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues., deletion in the 3' UTR polyA tract of EGFR is a common somatic mutation that occurs in microsatellite instability-high colorectal and endometrial carcinomas, These results suggest that EGF is secreted from A549 cells by MMP and increases claudin-2 expression mediated via the activation of an EGFR/MEK/ERK pathway., Our results suggest the possibility that the integrated effect of functionally-related EGFR and PAR-1 genes (haplotype cluster) is associated with susceptibility to airway hyperresponsiveness., Mutation of this amino acid led to increased ERBB receptor activation and upregulation of the ERBB3/PI3K/AKT signaling pathway, which was no longer responsive to MEK inhibition, data presented here demonstrate a reciprocal expression pattern between EGFR family members during keratinocyte maturation in the skin, and altered expression of EGFR and ErbB2 was identified in atopic dermatitis lesional skin as compared to healthy skin., Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity, This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma., Expression of pEGFR was associated with a significantly improved overall survival in reraly breast cancer., nonsmall cell lung cancers (NSCLC) harboring activating EGFR mutations were more likely to express low ERCC1 and thymidylate synthetase (TS) mRNA levels; patients with NSCLC who had ALK rearrangement were more likely to express low TS mRNA levels, Gene amplification is related with EGFR gene mutation in Chinese patients with non-small cell lung cancer., The in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients., in vascular smooth muscle cells, aminoterminal fragment of urokinase induced time-dependent phosphorylation, activation of alpha7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction, Using molecular dynamics simulations, study finds that the N lobe dimerization interface of the wild-type EGFR kinase domain is intrinsically disordered and that it becomes ordered only upon dimerization; some cancer-linked mutations distal to the dimerization interface, particularly the L834R mutation, facilitates EGFR dimerization by suppressing this local disorder., concentrations in colostrum/milk high on day 1 (greater than 10 ng/ml) but gradually declined by days 2, 5, and 30, findings suggest that TIF2 is a novel binding partner for nuclear EGFR and is involved in regulating its target gene expression., we have identified signaling events coordinated by EGFR and integrin alphavbeta5 that regulate the invasive behavior of human carcinoma cells., a novel mechanism of action of perifosine, directly inhibiting EGFR/MET-AKT1/3 axis, providing a rationale for a novel translational approach to the treatment of MMe., It was shown that the main consequence of T-cad silencing in squamous cell carcinoma is facilitation of ligand-dependent EGFR activation. T-cadherin modulates the EGFR pathway activity by influencing membrane compartmentalization of EGFR., EGFR expression in a mutant with reduced presence of beta1,4-galactosyltransferases-I-VI was markedly reduced, Aberrations of p53 and epidermal growth factor receptor genes are possibly involved in progression of esophageal basaloid squamous cell carcinoma., Plasma EGFR mutations are associated with non-small cell lung cancer., in azoospermic men decreased expression of EGFR may be responsible for decreasing GJA1 levels and increasing its cytosolic localization via the PI3K/AKT signaling pathway, Results indicate that epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment is more efficient in patients with EGFR exon 19 deletion than those with EGFR L858R mutation., EGFR soluble isoforms and their transcripts are expressed in meningiomas., alpha5beta1 integrin up-regulates proliferation via activation of EGFR, Our study probes the possibility that HPV infection is more frequent in patients with EGFR mutation or those who are sensitive to Erlotinib., EGFR signaling is activated in human hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas., In conclusion, SPRY2 is an important tumour suppressor in prostate cancer since its loss drives the PI3K/AKT pathway via functional interaction with the ErbB system., A transcriptional network involving the tumor suppressors Kruppel-like factor 6 and forkhead box O1 negatively regulate activated EGFR signaling in both cell culture and in vivo cancer models, Our data highlights a new functional synergism between oncogenic EGFR and PIK3CA with WNT/beta-catenin conferring high tolerance to oxidative stress generated by nutrient deprivation., Our results, combined with previous studies, suggested an association between the EGFR gene and glioma development., Studies indicate roles for enhanced EGFRtk phosphorylation and its downstream endoplasmic reticulum (ER) stress in cardiac fibrosis and microvascular endothelial dysfunction in type 1 diabetes mellitus., this study is the first to examine the prevalence of EGFR and KRAS mutations in a South American Brazilian population., High EGFR expression and mutations in the EGFR signaling pathway are associated with treatment response in head and neck squamous cell carcinomas., The authors propose that GRP-94, EGFR, fibronectin and TSP-1 are involved in the aggregative adherence of enteroaggregative Escherichia coli-T8 to INT-407 cells., that only EGFR-positive leukaemic cells respond to antibody-dependent cellular cytotoxicity of cetuximab, the monoclonal antibodies against EGFR, 41 specimens (33.6%) were positive for EGFR mutation., the expression levels of EGFR, pAkt, and PTEN differ between oropharyngeal and oral cavity cancer and it may be attributed to HPV-related molecular pathogenesis, High levels of EGFR phosphorylation in complete hydatidiform moles is positively correlated with aggressiveness of the disease., Activation of EGFR inhibits the interaction of PCNA with CUL4A, whereas inhibition of EGFR leads to increased CUL4A-PCNA interaction and CUL4A-dependent ubiquitin-mediated degradation of PCNA, STAT1 gene expression is enhanced by nuclear EGFR., EGFR protein expression is common in salivary gland tumors but is not associated with gene amplification, with activating mutations of EGFR being rare., strong protein expression of IGF-1R and EGFR was observed in thymic carcinoma and in both thymoma and thymic carcinoma, respectively. However,IGF-1R or EGFR gene amplification was rare in thymic epithelial tumors irrespective of protein expression., EGFR ser1166 phosphorylation site represents a regulatory site that exerts a negative regulation on growth and proliferation of cancer cells., Helicobacter pylori CagA activated the cellular tyrosine phosphatase, SHP-2, terminating EGFR activation and downstream signaling and increasing bacterial viability., The combined effects of EGFR downregulation, ligand competition, and immune effector function conspire to inhibit tumor growth in xenograft models of cetuximab-resistant BRAF and KRAS mutant cancers., EGFR mutation is associated with response to treatment in adenocarcinoma of the lung., 70 % of pulmonary adenocarcinoma female non-smoker Asian patients harbor EGFR mutations., USP2a antagonizes EGFR endocytosis and thus amplifies signaling activity from the receptor., This study developed a model to estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor., NM II plays a role in the internalization of the EGFR and EGFR-mediated signaling pathways., Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal ke, Epidermal growth factor receptor nonsense mutations are associated with clinical response in non-small-cell lung cancer., Aim of this study was to characterize further the expression of RUNX3 in lung cancers.Inactivation of RUNX3 was observed in 70% of the adenocarcinoma samples, and this was associated with promoter hypermethylation but not biased to EGFR/KRAS mutations., results delineate a novel association of nuclear DeltaEGFR with STAT5b, which promotes oncogenesis and treatment resistance in glioblastoma by direct regulation of anti-apoptotic gene, Bcl-XL, DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC., Evaluation of tumor aggressiveness in terms of EGFR responsiveness showed a reduced expression in carcinomas correlated with the increase in quantity of the mucinous component. In addition, EGFR reactivity was increased in the tumor invasion front., TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung., Results show that the cellular receptors, FAK, CD44v6, c-Met and EGFR, are biomarkers of survival and tumour progression in colorectal cancer. Increased staining for each receptor was also followed by expression elevation of at least one other marker., Lung neoplasm patients who harbor EML4-ALK fusion genes generally have wild type EGFR and KRAS genes., increased activation of AXL and evidence for epithelial-to-mesenchymal transition in multiple in vitro and in vivo EGFR-mutant lung cancer models with acquired resistance to erlotinib in the absence of the EGFR p.Thr790Met alteration or MET activation, EGFR mutation rate in Korean patients with non-adenocarcinoma of the lung is relatively high and that the clinical outcomes of EGFR TKIs are modest., genetic association studies in a population in Republic of Korea, Significant differences between the cell lines were found in EGFR expression but not in phosphorylation of EGFR without EGF stimulation, Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1., A higher expression of EGFR gene in the cytoplasm may have important effect on the progression of invasive salivary adenoid cystic carcinoma., Presence of membrane-bound ERalpha expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between membrane-bound ERalpha and EGFR mutation, Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk., AnxA6 is a new PKCalpha scaffold to promote PKCalpha-mediated EGFR inactivation., EGFR amplification and rearrangement are early events in tumorigenesis and EGFRvIII follows a model of hierarchical expression., The study provides a mechanistic link between the miR-200 family and EGF/EGFR in the regulation of the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer., Data suggest that protein tyrosine phosphatase non-receptor type 6 (SHP-1) may interact with EGF receptor (EGFR) to inhibit proliferation., impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity, The endosomal recycling of the EGFR and ErbB2 receptors is associated with efficient K63-polyubiquitination, but significantly decreased Hrs tyrosine phosphorylation as well as impaired deubiquitination by AMSH., The results indicated that EGFR polymorphism does not show any significant association with breast cancer., Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling., In patients with lung adenocarcinoma EGFR mutations were associated with longer overall survival., a novel role of nEGFR in radioresistance, and that is, upon ionizing radiation, nEGFR inactivates the ribonuclease activity of PNPase toward c-MYC mRNA through DNAPK-mediated Ser-776 phosphorylation, Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells, Mechanisms for drug resistance were explored due to poor clinical response to EGFR-targeted therapy. EGFR-targeted therapy combined with other treatment modalities may bring about better progress for treating epithelial ovarian cancers. (review), Overall, our results suggest that PTPs regulate multiple receptor-level phenomena via their action at the plasma membrane and cell interior and point to new possibilities for targeting PTPs for modulation of EGFR dynamics., TAZ-dependent secretion of AREG indicates that activation of the EGFR signaling is an important non-cell-autonomous effector of the Hippo pathway, and TAZ as well as its targets may play significant roles in breast tumorigenesis and metastasis., Chemotherapy may reduce EGFR mutation frequency in patients with non-small cell lung carcinoma, likely the result of a preferential response of subclones with EGFR mutations in tumors with heterogeneous tumor cell populations., The aim of this study was to elucidate the correlation between the expression of cancer/testis antigens and clinicopathological factors, including the EGFR mutation, and to analyse the prognosis in lung adenocarcinoma., Standard cytology provides adequate material for the assessment of EGFR and Kras mutational status in non-small cell lung cancer and colorectal cancer patients., Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination., A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)., The frequency of EGFR mutations in Lithuania patients with nonsquamous NSCLC was found to be similar to that reported in Europe. EGFR mutations were more frequent in women and never-smokers., EGFR exon mutation is associated with non-small-cell lung cancer., Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways., An increase of EGFR expression during chemoradiation may be associated with significantly shorter DFS and OS., CsA may promote EGFR activation via CXCL12/CXCR4 axis, and EGFR downstream ERK signaling pathway may be involved in the CsA-induced proliferation of human trophoblast cells., a region in exon 19 is highly unstable in a large proportion of patients carrying EGFR deletions, Robust co-regulation of tyrosine phosphorylation sites has been revealed on novel protein interactions between EGFR and PDLIM1., Interaction of E. faecalis with host cells and production of hydrogen peroxide increase EGFR activation, thereby contributing to cell proliferation., In ER-positive breast cancer, correlations were found in the expression of activated HER-receptors (pHER1, pHER2, pHER3), indicating a potential role of HER1 and HER3 in the activation of HER2. HER1 expression was not associated with prognosis., Epidermal growth factor receptor gene is upregulated in CRCC and associated with OPN gene expression and NF-kB signaling, data demonstrate that EGFR internalization is critical for hepatitis C virus entry and identify a hitherto-unknown association between CD81 and EGFR, EGFR mutation is associated with response to therapy in lung cancer., we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR phosphorylation and mediates EGFR/pEGFR trafficking out of early endosomes, These data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells., None of the cases was immunopositive for IDH1 and EGFR. p53 protein expression was observed in three cases with 25-30 % of cells showing weak to moderate staining., Authors suggest EGFR mutations are seen in greater frequency in mucoepidermoid carcinoma(MEC)in Asian populations, and that in these populations, EGFR mutations are seen in pulmonary but not in salivary MEC., we report for the first time the amplification of the coding exon 8 of EGFR in invasive breast cancer, The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas., Data indicate that miR-133b can interact specifically with the 3'-UTR of epidermal growth factor receptor (EGFR) mRNA., EGFR mutation was a predictor for advanced squamous cell lung cancer susceptibility to EGFR tyrosine kinase inhibitors., Three mutations in EGFR in endometrial cancer were identified. Two of these, were not associated with response to lapatinib or progression-free survival. One newly identified mutation was associated with partial response and progression-free survival., The effective diffusion constant is negatively correlated with the respective dwell time for different SH2 domains and the dwell time is positively correlated with the local density of receptor tyrosine kinases phosphorylation., EGFR mutation is associated with response to therapy in non-small-cell lung cancer., EGFR Exon 20 mutations are associated with response to therapy in non-small-cell lung cancer., EGFR T790M mutation is associated with response to therapy in lung cancer., sex bias occurrence of hepatocellular carcinoma associated with EGFR, pTyr1068 may be a predictive biomarker for screening the population for clinical response to EGFR-TKIs treatment; especially for patients with wild-type EGFR., Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma., The critical importance of a reciprocal relationship between DNA-PKcs phosphorylation and EGFR-mediated radiation response, was examined., Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration, HGF regulated Src homology domain 2-containing inositol 5'-phosphatase 2 recruitment to EGFR and inhibited LPS-induced inflammation via EGFR degradation., data indicate that SCD activity may control lung cancer cell metabolism, proliferation and survival by modulating the EGFR-->Akt/ERK signaling platforms, The results provide important information on how EGFR phosphorylation levels are regulated within cells., findings demonstrate that WT-EGFR is a client protein of HSP90 and that their interaction is critical for maintaining both the stability of the receptor as well as the growth of EGFR-dependent cancers., Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model, ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation., AnxA2 has a role in EGFR-Src membrane bound signaling complex and ligand induced activation of downstream signaling pathways, Increased expression of wtEGFR or EGFRvIII leads to differential effects on protein expression and tyrosine phosphorylation signaling networks., Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function., PolyQ-htt controls EGFR degradation and recycling in fibroblasts from Huntington disease patients., EGFR mutations are associated with HPV presence in Japanese patients with lung cancer., positivity, but not HER2 positivity, was associated with poor patient outcomes after curative resection of stage II/III gastric cancer., EGFR amplification and EGFRvIII expression were associated with an unfavourable prognosis for glioma patients, EGFR mutation is associated with response to therapy in non-small-cell lung cancer., EGFR mutation is associated with response to therapy in non-small-cell lung cancer., EGFR delE709_T710insD, apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma, Results provide insights into the relative energetics of intracellular and extracellular dimerization in epidermal growth factor receptor (EGFR)., Data show that the EGFR is tyrosine-phosphorylated following treatment of IECs (HT-29 and IEC-6) with TNF-alpha. This requires EGFR autophosphorylation as it was blocked by the EGFR kinase inhibitor AG1478., Overview of the role of EGFR in glioblastoma and as a target for treatment of glioblastoma. [Review Article], Cytokeratine 5/6 and EGFR expressions showed correlation so these markers are reliable to diagnose basaloid type tumors with a 5% cut-off value., Study indicates the efficacy of stem cells-based EGFR targeted therapy in glioblastoma multiforme (GBM)., In patients with smoking histories up to 10 pack-years, EGFR mutation predominated over KRAS mutation., The length of (CA)n in EGFR and (CTG)n in NOTCH4 was not associated with breast cancer (OR=0.99; 95% CI 0.59-1.37; p=0.619 and OR=1.08; 95% CI 0.71-1.65; p=0.725, respectively)., Inactivation of EGFR by the monoclonal antibody Cetuximab and RNA interference against STAT3 or DeltaNp63alpha., TBC1D16 is a GTPase activating protein for Rab4A that regulates transferrin receptor recycling and EGFR trafficking and signaling., EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways have roles in colorectal cancer and treatment [review], EGFR mutations in concert with P53 mutations accelerate cancer development and lead to evolution of therapeutic resistance, inhibition of EGFR expression reduced HER2-induced anchorage-independent growth and tumorigenesis, EGFR 3'UTR 774T>C polymorphism may contribute to susceptibility to bladder cancer in Chinese population., These results describe a unique role for EGFR and Met in mammary epithelial cells., This review describes the mechanisms by which colorectal cancers gain resistance against EGFR-targeted therapies as well as strategies to bypass mutationinduced resistance in these two signaling pathways. [review], In lung cancer, EGFR mutation occurs cumulatively by unidentified internal/external factors other than smoking., Membranes and cytoplasm of the tumor cells showed variable EGFR staining intensities with a range of immunopositive cancer cells from 0% to 100%, we show for the first time that HGF-induced EGFR tyrosine kinase-inhibition is a very common mechanism in human cancers, Results suggest that pAKT is activated by hypoxia in an EGFR-independent way in tumors., Overexpression of EGFR predicted better response to neo-adjuvant chemotherapy in patients with triple negative breast cancer ., A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment., the largest series of Intestinal-type sinonasal adenocarcinoma published to date, EGFR alterations were frequently observed., EGFR mutation is associated with response to therapy in lung cancer., high concentration of gefitinib is not necessary to achieve long-term therapeutic effects in patients with lung adenocarcinoma harboring the EGFR mutation, Human bone marrow-derived mesenchymal stem cells transfected with microRNA-133a (miR-133a), which targets EGFR, were observed to express cardiac-specific markers., EGFR SNP-216G/T polymorphism was a potential predictor of clinical outcomes in NSCLC patients treated with EGFR-TKI., Upregulation of EGFR expression is associated with glioma., EGFR mutation is associated with response to therapy in brain metastases of non-small cell lung carcinoma., Nuclear localization of EGFR on activation with transforming growth factor-alpha was observed in SQ20B, but not in UMSCC47. SQ20B also had increased gammaH2AX foci compared to UMSCC47, suggesting that SQ20B has more DNA damage compared to UMSCC47., Case Report, a profound activation of the EGFR system in breast cancer, The low rate of K-ras and EGFR mutations, coupled with the high surface expression of EGFR, suggests similarity in the EGFR signalling pathway between Squamous cell anal carcinoma and squamous cell carcinoma of the head and neck., In COPD airways, aberrant EGFR activity increases PI 3-kinase/Akt-mediated phosphorylation of FoxO3A, thereby decreasing nuclear FoxO3A and increasing chemokine expression., High ErbB1 expression is associated with triple negative breast cancer., EGFR expression levels may determine distinct patterns of monoclonal antibodies (mABs) that contribute to the therapeutic efficacy of EGFR mAb., UbcH10 expression is significantly higher in squamous cell and large cell carcinomas than in adenocarcinomas, and directly and inversely correlated with the mutational status of p53 and EGFR, respectively., Overexpression of EGFR or EGFRvIII, accompanied by a loss of PTEN, contributed to the activation of multiple intracellular signalling pathways in GBM cells., EGFR mutations are associated with radiotherapy response in non-small cell lung cancer patients with brain metastases., The mutation rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors., Expression of EGFR is seen both in hepatocytes and biliary cells of the clusters as well as in adjacent biliary ductules in liver failure., data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease, Fucoxanthin inhibited the expressions of the epidermal growth factor receptor (EGFR) and STAT3 and phosphorylated STAT3 proteins., in human colon cancer cells Src-mediated cross-talk between FXR and EGFR modulates ERK phosphorylation, thereby regulating intestinal cell proliferation and tumorigenesis., The triple negative phenotype in endometrial endometrioid adenocarcinoma is associated with poor prognostic surgical-pathological factors, worse prognosis and overexpression of EGFR., Report metabolic cooperation between the EGFR/PKC-epsilon/NF-kappaB pathway in PKM2 upregulation and tumorigenesis., a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor surface levels and EGF-induced downstream signaling., Phospho-Akt immunoreactivity in prostate cancer shows a relationship to disease severity and outcome, Ki67 and phosphorylated EGFR expression, Patient with EGFR-mutated lung adenocarcinoma benefited with high dose pemetrexed and gefitinib chemotherapy., Molecular characterization of single CTCs demonstrated considerable intra- and interpatient heterogeneity of EGFR expression and genetic alterations in EGFR, KRAS, and PIK3CA, Results suggest a possible participation of erbB1-4 and claudin-1 in tissue remodelling in chronic hypertrophic rhinitis., Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer., A novel mechanism further defining the effect of E2/S1P on the EGFR transactivation in breast cancer cells., These data suggested that the Pkd1 mutation induced upregulation of HDAC6 might act to slow the trafficking of EGFR, EGFR protein expression (any grade) and overexpression (3+) were observed in 43% and 11% of patients, respectively., EGFR mutation is associated with response to therapy in lung cancer., EGFR mutation is associated with metastasis in non-small-cell lung cancer., EGFR mutation is associated with response to therapy in non-small-cell lung cancer., Exon 19 EGFR mutation is associated with small-cell lung cancer with adenocarcinoma., EGFR status can be determined in non-small cell lung cancer using silver-enhanced in situ hybridization., ligand induces kinase-inactive, pre-formed EGFR dimers and heterodimers to change conformation leading to kinase-active tetramers, where kinase activation occurs via an asymmetric interaction between EGFR dimers, Simultaneous expression of LAMP1 and EGFR correlates with the ovarian neoplasm grading., Recent evidence defines how EGF receptor is involved in tumor formation in pancreatic cancer., The results of our study suggest an association between recurrence pattern and EGFR mutational status in recurrent female NSCLC patients., In human colorectal carcinogenesis, EGFR copy number increases progressively, from adenomas with high-grade dysplasia to locally advanced adenocarcinomas, through early invasive adenocarcinomas., cell growth under hypoxic conditions led to activation of EGFR signaling and induction of EMT phenotype., results demonstrate that Rab7 CMT2B mutants impair growth factor receptor trafficking and, in turn, alter p38 and ERK1/2 signaling from perinuclear, clustered signaling endosomes, 3 lung adenocarcinoma patients with early venous thromboembolisms had activating mutations in EGFR, suggesting such mutations may increase thromboembolic risk., PKC-dependent phosphorylation of Thr654 regulates EGFR polarity in MDCK cells., MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer., The present study revealed that ESCC of Brazilian patients do not present mutations in hot spots of EGFR, K-RAS and BRAF and only a minor proportion present overexpression of EGFR or HER2., EGFR gene mutation is associated with response to therapy in lung cancer, EGFR mutations were detected in 15.7 % of both the NSCLC primary tumor and lymph node metastasis and in 14.3 % of the PT only., Acetylcholine increases the proliferation rate of tenocytes through mAChR stimulation and this mechanism operates via the extracellular activation of the epidermal growth factor receptor., PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation, ERBB1 and ERBB2 have different roles in response to antineoplastic agents in colorectal cancer cells, epimorphin modulates the signaling pathways mediated by EGFR for epidermal tissue organization, The results demonstrated that EGF bound to EGFR more stably in the cells co-expressing EGFR and HER2, and the binding enhancement in the presence of HER2 was inhibited by either Trastuzumab or Pertuzumab, These results suggest that flagellin regulates the residence time of EGFR on the plasma membrane and thus the signaling of EGFR through phosphorylation of Ser1047 by MAPKAPK-2., EGFR and Her2 were significantly upregulated in lymph node metastasized colorectal cancer (LNM CRC) compared to non-LNM CRC., The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers., Mutations affecting BRAF, EGFR, PIK3CA, and KRAS are not associated with sporadic vestibular schwannomas., EGFR mutation is associated with responsiveness to therapy in lung adenocarcinomas., Survival in EGFR expressing glioblastoma patients was significantly less than that in non-expressing patients., we suggest that CM1 could be developed as a therapeutic target of lung cancer regardless of EGFR mutation status., In this study we explored the potential of combining either erlotinib with cetuximab or trastuzumab to improve the efficacy of EGFR targeted therapy in EGFR wild-type NSCLC cell lines., pAkt expression significantly correlates with HER2 expression and with a poor prognosis in gastric cancer., These results imply there is a functional effect of germline EGFR variants on tumor progression in glioma., EGFR gene copy number is highly heterogeneous within individual NSCLCs and this finding might well be a reason for the controversial clinical data existing regarding responsiveness to anti-EGFR therapy., Data indicate that the invasive phenotype of MDA-MB-231 cells is mediated by phospholipase D2 (PLD2) under direct regulation of both Janus kinase 3 (JAK3) and tepidermal growth factor receptor (EGFR)., EGF receptor single nucleotide polymorphisms have a cumulative effect on decreasing lung adenocarcinoma risk in never-smoking women with hormone replacemtn therapy use., Aberrations of MET are associated with EGFR and PTEN signalling and might possess relevance for targeted therapies of salivary gland carcinomas in the future., EGFR mutations were significantly identified in adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic-predominant adenocarcinoma, and papillary-predominant adenocarcinoma subtypes., collegiate smokers (former smokers who smoked between 101 lifetime cigarettes and 5 pack-years)with advanced-stage lung cancers represent a distinct subgroup of patients with a higher frequency of KRAS mutations and lower frequency of EGFR mutations compared with never smokers, Data indicate that BRAF and EGF receptor or SRC family kinase inhibition blocked proliferation and invasion of the resistant tumors., EGFR mutations appear to be a rare event in Esophageal squamous cell carcinoma in high incidence areas of central Asia, Xanthohumol is a potent antineoplastic chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition., Data indicate that the PTEN loss and activation of AKT signaling pathway contributed to erlotinib resistance in EGFR-mutant non-small cell lung cancer (NSCLC) cell line H1650., Transcriptional regulation of target genes by association with gene regulatory chromatin in cooperation with c-Myc by nuclear DeltaEGFR makes a unique contribution to its oncogenicity., mutation is associated with more frequent distant relapses of non-small cell lung cancer, The EGFR mutation research should be performed in all patients with NSCLC, giving the possibility to a considerable number of patients to perform a first line treatment with TKI (EGFR mutated patients), Data indicate that EGFR expression level is not a clinically useful predictive biomarker in these studies., CD44 therapy in HNSCC may target the CSC population and alter EGFR signaling, The potential mode of recognition of one of the autophosphorylation sites in the C-terminal tail, Tyr-1016, by the kinase domain revealed by X-ray crystallography., family history of cancer is higher in the EGFR mutated cohort, Vandetanib might be effective in non small cell lung carcinoma with EGFR mutations that lack PTEN expression., Newly developed ovarian serous adenocarcinoma cell line, TU-OS-4 overexpresses FGFR., Dysregulation of epidermal growth factor receptor (EGFR) has been associated with colorectal cancer, but no evidence shows a relationship of EGFR expression to clinicopathological parameters in colorectal cancer in Taiwan., Mutations in epidermal growth factor receptor gene is associated with response to therapy in non-small-cell lung cancer., Epidermal growth factor receptor mutation is associated with response to therapy in resected advanced non-small-cell lung cancer., Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells., Data suggest mechanisms of carcinogenesis by heavy metals involve increased activation of signaling pathways involving EGFR, PI3K/AKT (phosphatidylinositol 3-kinase/proto-oncogene protein c-AKT), and mTOR (mechanistic target of rapamycin). [REVIEW], The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia, Prognosis is worse in non-small cell lung cancer patients with KRAS mutation than that with wild type., EGFR was upregulated in of adrenocortical carcinoma patients, whereas EGFR expression was mostly negative in adrenocortical adenoma patients., Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9., The status of EGFR and KRAS mutation in serum was not prognostic in patients with advanced non-small cell lung cancer, Epidermal growth factor receptor mutation is associated with response to therapy in advanced non-small-cell lung cancer., EGFR single nucleotide polymorphisms are associated with response to therapy in non-small-cell lung cancer., Patients with concomitant IGF1R/EGFR fluorescence in situ hybridization immunohistochemistry had a worse disease-free survival and overall survival, EGFR mutation is associated with breast cancer., reducing EGFR activity strongly reduced pSTAT3 in vivo, Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction., Results suggest an alternative strategy that combines noncompetitive antibodies to achieve robust degradation of EGFR and tumor inhibition., EGFR exon 20 insertions is associated with non-small-cell lung cancer., our data suggest that the dual inhibition of FAK and EGFR by using plasmid vector-based RNA interference might be a novel therapeutic approach to the treatment of human non-small-cell lung cancer ., EGFR and KRAS mutational rates were comparable in primary and unpaired metastatic lung adenocarcinoma in pre-chemotherapy and postchemotherapy groups., The prevalence of EML4-ALK, EGFR status and KRAS mutations in 208 Chinese patients with non-small cell lung cancer, is reported., the combination of dovitinib + NVP-BEZ235 or dovitinib + AEE788 results in strong inhibition of tumor growth and a block in metastatic spread. Only these combinations strongly down-regulate the FGFR/FRS2/Erk and PI3K/Akt/mTOR signaling pathways, DUOX1 plays a central role in epithelial defense responses to infection or injury, by mediating oxidative activation of Src and ADAM17 in response to ATP-dependent P2Y(2)R activation as a proximal step in EGFR transactivation and downstream signaling., this study found an association between PTPN22 rs2476601 and EGFR rs17337023 polymorphisms and the risk of rheumatoid arthritis in a sample of Iranian population., Data indicate that the concordance between EGFR and KRAS mutational status in 29 paired scraped smears and needle washing was 100%, with 7 paired samples showing the same EGFR mutation and 8 paired samples showing the same KRAS mutations., EGFR and KRAS mutations are frequent in adenocarcinomas and are not prognostic factors for survival., study anlayzed a mother and daughter with lung cancer with squamous differentiation; sequence analysis of EGFR on tumor-derived DNA revealed the copresence of 2 missense mutations in exon 18 [c.2155G>A, p.(G719S)] and in exon 20 [c.2327G>A, p.(R776H), Suppression of STAT3 phosphorylation with WP1193 reduced HGF expression in DeltaEGFR-expressing GBM cells., EGF receptor inhibits the Hippo pathway through activation of PI3-kinase (PI3K) and phosphoinositide-dependent kinase (PDK1), but independent of AKT activity., There is a parallelism between an increase in EGFR expression and increase in the histopathologic grading of salivary gland mucoepidermoid carcinoma., Results suggest that the impact of irradiation on tumor cell migration depends on radiation type and cell line., Epidermal growth factor receptor mutation is associated with lung carcinomas., Data suggest that EGFR activation mediates PPARG- (peroxisome proliferator-activated receptor gamma-) induced sodium and water reabsorption via upregulation of NHE3 (sodium/hydrogen exchanger 3) and AQP1 (aquaporin 1) in proximal tubules., EGFR contains many different glycans at multiple sites and the majority of them are quite similar between membrane-bound and -secreted forms., in a cohort of patients with lung adenocarcinomas, study found EGFR exon 20 insertions are a highly heterogeneous family of activating mutations with an incidence that is higher than previously reported, EGFR are the key mediators of SDC-4 expression in MCF-7 cells., Study concludes that EGF binding removes steric constraints in the extracellular module, promoting activation of EGFR through N-terminal association of the transmembrane helices., Studies highlight the previously largely overlooked role of the membrane in maintaining the coupling of EGFR extracellular domains with the rest of the receptors., CA-SSR-1 (intron-1 CA repeat) polymorphism in EGFR is a strong predictive factor for tumor recurrence and overall survival in patients with complete resected esophageal cancer without neoadjuvant or adjuvant therapy., Report improvement in the quality of molecular analysis of EGFR in non-small-cell lung cancer detected by three rounds of external quality assessment., Transforming growth factor-alpha/hyaluronic acid-mediated migration and proliferation of keratinocyte requires activation of ErbB1 receptor., EGFR mutation status significantly affected the chemotherapy patterns in advanced non-small cell lung cancer ., High expression of EGFR was related to poor survival of colon cancer., Both sensitivity to EGFR-tyrosine kinase inhibitors and relative kinase activity differed among several EGFR mutations., EGFR mutations and ALK rearrangement is associated with resistance to EGFR tyrosine kinase inhibitors in lung cancer., Tissue samples burdened with specific oncogen signatures like EGFR gene amplification could be detected in precancerous lesion. This might improve follow-up and treatment protocols of glottic lesions, These data indicate that constitutive EGFR activation promotes the aggressive invasive behavior characteristic of malignant peripheral nerve sheath tumors, epidermal growth factor receptor has a pathophysiologic role in pemphigus acantholysis, miR-7 efficiently silenced some genes involved in the epidermal growth factor receptor (EGFR) pathway and achieved favorable effects in treating glioma in vivo and in vitro, Aberrant EGFR signaling contributes to malignant conversion of HPV16+ head and neck squamous cell cancer cells., EGFR mutation is associated with response to therapy in lung cancer., Epidermal growth factor receptor mutation is associated with lung carcinomas., This review summarizes recent advances in tyrosine kinase inhibitors development with special focus on rational strategies for the design of potent EGFR inhibitors including molecular modeling studies based on crystallographic data., The activation of EGFR by EGF induces redistribution of surface T-cad to sites of cell-cell contact and its colocalization with phosphorylated EGFR by p38MAPK and Rac1 as key downstream signalling mediators., Eag1 K+ channel and ErbB were expressed in all human pituitary adenomas examined while ErbB2 expression was more variable., In cortical precursor cells, EGFR sigaling activates tyrosine kinase (Trk)C and TrkB receptors., In patients with non-small cell lung cancer, EGFR mutant content was correlated with the response and prognosis of EGFR tyrosine kinase inhibitors., Report mutation-specific immunohistochemistry, using optimized procedures, as a reliable prescreening test for detecting EGFR mutations in lung adenocarcinoma., This study showed that patients with pulmonary adenocarcinoma and ILD had a lower probability of carrying tumor EGFR mutations., It is reasonable to suggest that personalized therapy for NSCLC patients should include a genetic assessment of the EGFR mutational status for individual patients., EGFR mutation in Uighur lung adenocarcinoma patients (16.2%) is significantly lower than that in Han lung adenocarcinoma patients (45.7%)., Results indicate that activation of wild-type EGFR promotes invasion and glioblastoma development independent of angiogenesis, whereas loss of its activity results in angiogenic tumor growth., Data indicate that dual inhibition of EGFR with erlotinib and cetuximab, combined with the VEGF antibody bevacizumab, is well-tolerated, and merits further investigation., EGFR gene copy number as a potential biomarker of survival for patients with advanced colorectal cancer receiving treatment with anti-EGFR mAbs[Review], Our results also showed that EGFR and CXCR4 are potential therapeutic targets for NSCLC and that simultaneous inhibition of EGFR and CXCR4 in NSCLC patients with concomitant expression of both CXCR4 and EGFR may be an effective treatment strategy., Our results will add to the body of evidence, which supports that approximately 4% of anaplastic lymphoma kinase-rearranged (ALK+) tumors can have coexisting EGFR mutations., That block IKKalpha/beta and EGFR pathways., EGFR expression is significantly associated with tumor staging and depth in esophageal squamous cell carcinoma., The effects of EGFR on maintaining cancer stem cells are mainly mediated by AKT signaling via beta catenin., Expression of phosphorylated EGFR in cholesteatoma was significantly increased when compared with normal external ear canal epithelium. In cholesteatoma epithelium, a significant positive association was observed between p-EGFR and p-Akt expression., Our study demonstrated that EGFR mutated Adenosquamous carcinoma of the lung had similar clinicopathological features as EGFR mutated adenocarcinoma, Our study suggests that there is a link between ALDH1 and EGFR expression in high-grade serous ovarian carcinoma, Exon 21 missense mutation was more frequent in lepidic predominant adenocarcinomas than in other histologic subtypes. GGO volume percentage in tumors with exon 21 missense mutation was higher than that in EGFR wild-type tumors and exon 19-mutated tumor., In a large cancer center in Korea, the proportion of EGFR testing increased from 2007 through 2010. The high frequency of EGFR mutation positive cases warrants the need for generalized testing in Asian NSCLC patients., Data indicate that EGFR T790M as the most common mechanism of acquired resistance, whereas MET amplification, HER2 amplification, and small cell histologic transformation occur less frequently., analysis of epidermal growth factor receptor internalization after activation with different ligands, Epidermal growth factor receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast cancer, SPINK1 plays a role as a growth factor, signaling through the EGFR pathway in pancreatic ductal adenocarcinoma and neoplasms, and that the EGFR is involved in the malignant transformation of IPMN., The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR) and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles., Recognition of the presence and significance of specific EGFR mutations is important for appropriate therapeutic implementation of EGFR TKIs and research and development of mutation-specific inhibitors, EGFR mutations are associated with papillary lung tumors., exon 21 EGFR mutations are associated with response to therapy in lung adenocarcinoma., We submit that the EGFR expression is not a useful prognostic element to identify patients with a major risk of meningioma recurrence, Results ndicate the utility of serum DNA as a resource and pyrosequencing as a method for the detection of EGFR mutations in advanced non-small cell lung cancer (NSCLC)., 23494210:Radioiodinated PYK, one of the newly synthesized quinazoline derivatives, was found to be a desirable ligand for EGFR-TK SPECT imaging. [(125)I]PYK showed high tumor accumulation and selective EGFR-TK binding. \, EGFR mutations are associated with metastatic lung adenocarcinoma., Newly produced four recombinant hIgG antibodies recognize 4 different sites (epitopes) in 3 different extracellular domains of EGFR and exhibit different biological effects on cancer cells., Resistance to EGFR-TKI develops within less than one year in EGFR-mutated lung cancer patients., correlation between EGFR mutation genotype and the radiotherapy, The most frequent activating EGFR mutations detected in non-small setting lung cancer are absent in penile cancer, Case Report, Only 18.2% (12/66) of patients carried EGFR mutations after Neoadj-Chemo (p = 0.013). The median peak value of EGFR 19 exon mutations decreased non-significantly after Neoadj-Chemo., The interplay between EGFR and AURKA provides an explanation for the difference in EGF dependency between EGFR-WT and EGFR-mutant cells and may provide a new therapeutic strategy for lung cancer patients carrying EGFR mutations., EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma., EGFR gene amplification is associated with response to therapy in lung adenocarcinomas., Results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR) signaling with Src activation and may provide a novel therapeutic target for treatment of breast cancer., these results suggest that coupling HDAC and HER2 inhibitory activities to an EGFR inhibitor may potentially be effective in overcoming drug resistance and preventing cancer cell migration, Germ line epidermal growth factor receptor T790M mutations concurrent with KRAS mutations are associated with lung cancer., MET and EGFR are overexpressed in esophageal carcinosarcoma suggesting molecular targeted therapies might be an effective line of treatment., this study suggests that combination of ATO and EGFR inhibitors is a promising therapeutic strategy against various solid tumors harboring wild-type EGFR., In HNSCC, there are tumor responses to gefitinib without protein-altering mutations in the EGFR gene., combined silencing of EGFR and Rictor should be an effective means of treating glioblastoma, The EGFR SNP rs2072454 was significantly associated with an increased risk of gastric cancer., A high EGFR copy number may predict benefit from tyrosine kinase inhibitors treatment for non-small-cell lung cancer patients with wild-type EGFR., Mutations in EGFR downstream pathways are not rare in malignant pleural mesotheliona. None of those found in this study seemed to be prognostically significant, Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression., PML IV can interact physically with nEGFR and represses the transcription of nEGFR target genes., EGFR mutant-lung adenocarcinoma with acquired resistance to EGFR-tyrosine kinase inhibitors responds poorly to radiotherapy for brain metastases., EGFR mutations are not associated with tyrosine kinase inhibitors treatment efficacy in non-small cell lung cancer., Genetic variations of the A13/A14 repeat located within the EGFR 3' untranslated region have no oncogenic effect in patients with colorectal cancer., EGFR expression was significantly associated with male sex and lymph node metastasis in papillary thyroid carcinoma patients., EGFR mutations are associated with lung adenocarcinoma., EGFR mutations are associated with lung cancer., Patients with an unchanged EGFR mutational status after chemotherapy were more likely to express ERCC1, and this change may serve as a clinical indicator of therapy response, RNAi-mediated knockdown of beta1,4GT1 increased the levels of EGFR dimerization and phosphorylation. These data suggest that cell surface beta1,4GT1 interacts with EGFR and inhibits EGFR activation, HAS2-dependent production of HA facilitates TGF-beta1-dependent fibroblast differentiation through promoting CD44 interaction with EGFR held within membrane-bound lipid rafts., Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients, HER1 497K variant had significantly increased breast cancer risk., High ErbB1 expression is associated with radioresistance in astrocytoma., EGFR mutation-specific antibodies could be an additional tool distinguishing primary versus metastatic carcinomas in the lung., Data indicate that the epidermal growth factor receptor (EGFR) mutation status was not associated with disease-free survival or overall survival in resected lung adenocarcinomas., EGFR expression level in gastric cancer is closely related to the incidence and development of gastric cancer, which can provide a theoretical basis for the targeted therapy for gastric cancer with EGFR as the target., Multiple primary malignancies occurred more frequently in patients with classic EGFR mutations, especially those with exon 19 deletions., presence of an EGFR gene mutation was a predictive factor for the response to EGFR-TKI treatment in patients with resected stage I adenocarcinoma, but was not a prognostic factor, Lung cancer derived exosomes contain EGF receptor and can induce tolerogenic dendritic cells., EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas., This study emphasizes EGFR mutation as an important predictive marker for response to oral tyrosine kinase inhibitors in the Indian population., activation of the MEK-ERK pathway contributed to EGFR-facilitated prostate cancer stem-like cell propagation., Serum CEA and CA242 levels are associated with mutations of the EGFR gene in patients with lung adenocarcinomas., Results indicate that ADAM17 is upregulated by hypoxia and contributes to hypoxia-induced cisplatin resistance via EGFR/PI3K/Akt pathway., Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer., A mechanism responsible for the generation of mitogenic IR-A via a novel interplay between IR and EGFR pathways in hepatocellular carcinoma., A fundamental role for the dual-specificity tyrosine phosphorylation-regulated kinase, DYRK1A, in regulating EGF receptor in glioblastomas., EGFR, which is the product of a well-characterized oncogene in human cancers, suppresses the maturation of specific tumour-suppressor-like miRNAs in response to hypoxic stress through phosphorylation of argonaute 2 (AGO2) at Tyr 393, PrP(C) over-expression enhances cell proliferation and cell cycle re-entrance after serum stimulation is due in part to the modulation of epidermal growth factor receptor (EGFR) by PrP(C) in the plasma membrane, Activation of epidermal growth factor receptor signaling determines the timing of centrosome separation., EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha, Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity., Mutations and amplification in EGFR genes are minor events in small intestine adenocarcinoma., we explored heterogeneity in expression of EGFR, VEGF and NOTCH1 in head and neck squamous cell carcinomas, miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer., Studies indicate that somatic mutations in EGFR result in kinase constitutive activation., Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN)., We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation, Two independent high-risk primary breast cancer subgroups for developing brain metastases were identified, represented by genetic alterations in either HER2 or EGFR/PTEN-driven pathways., Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng., Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes., the reduced expression of phosphor-EGFR and c-MET is chiefly responsible for all events of blocking metastasis., EGFR has the potential to regulate the neuronal intrinsic regeneration and mTOR and PI3K/Akt pathway activation may have an important role in it., Repeat biopsy identified pathological transformation to small cell lung cancers (SCLC) retaining the same EGFR mutation., Whose tumor had EGFR and ALK genetic aberration., Data indicate that TLR8 stimulation of NK-DC co-cultures significantly increased DC priming of EGFR-specific CD8(+) T cells in the presence of cetuximab., Wif1 methylation showed an association with unfavorable prognosis of adenocarcinoma (AC) patients with EGFR mutation., Data suggest that up-regulation of signaling via EGFR and ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) by leptin contributes to vascular dysfunction (as seen in obesity, metabolic syndrome, and diabetes). [REVIEW], miR-219-5p inhibits receptor tyrosine kinase pathway by targeting epidermal growth factor receptor in glioblastoma., IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase, Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation., EGFR interacts with Grb2 in both constitutive and EGF-dependent manners, whereas the HER3-Grb2 interaction requires the heteromerization of EGFR and HER3., The prognostic role of FLT1/VEGFR1, heparanase and epidermal growth factor receptor gene expression in patients with resected cholangiocarcinoma, was investigated., EGFRvIII upregulates the heterogeneous nuclear ribonucleoprotein (hnRNP) A1 splicing factor, promoting glycolytic gene expression and conferring significantly shorter survival in patients., NF-kappaB pathway was critically involved in the molecular mechanisms underlying the action of EGFR and inflammatory cytokines, affibody-based PET imaging of EGFR provides a promising approach for detecting Hepatocellular carcinoma in vivo., Data indicate that epidermal growth factor receptor (EGFR) signaling stimulates the expression of transcription factor early growth response 2 (EGR2) to promote osteoprogenitor proliferation and survival., The SABER method is a feasible means of determining the plasma T790M mutation status and could potentially be used to monitor EGFR-TKI therapy., Our findings do not provide sufficient evidence that EGFR L2 domain mutation is correlated with resistance to cetuximab in colorectal cancer, The association of EGFR mutation with family history of cancer also existed., Pleural effusion had a diagnostic performance for the detection of EGFR mutations in NSCLC., our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180, Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib, This new discovery has highlighted the possibility that there may be a relationship between inflammation, COX-2, EGFR, and CYP19A1 in malignant mesothelioma, EGFR is generated through proteolytic cleavage of a cell surface precursor of an alternately spliced EGF receptor isoform and that sEGFR binds to EGF with high affinity., A man with advanced adenocarcinoma who harboring exon 19 EGFR deletion and EML4-ALK gene translocation in the re-biospy specimen., DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (EGFR)of which 62% are hypermethylated., Suggest that activating mutations of EGFR, HRAS, and KRAS contribute to the pathogenesis of human seborrheic keratosis., The mutations of EGFR and BRAF genes were not found in HER2-mutated patients with brain metastasis from non-small cell lung cancer., Data suggest that detection of ductal carcinoma in situ (DCIS) based on marker expression during breast conserving surgery should be possible with a panel of molecular imaging tracers targeting CD44v6, GLUT1, HER2, IGF1-R, and EGFR., Our data identify a novel therapeutic approach to the treatment of FGFR3-mutant cancer, emphasizing the potential of combination approaches targeting both FGFR3 and EGFR., EGFR-H could be an important biomarker for aggressive papillary thyroid carcinomas, particularly in BRAF wild-type tumors., Epidermal growth factor receptor mutations are more common among females, never-smokers, and patients with adenocarcinomas of the lung and patients with exon 18 mutations have a worse survival, EGFR amplification is associated with response to therapy in glioblastoma., A novel, time-dependent change in the relationship between total ERK and phosphorylated ERK levels that persists without negative feedback, is reported., Whereas the wild-type EGFR catalytic domain monomer is mostly found in an inactive conformation, there is a clear shift toward the active conformation for all of the mutant EGFR kinases., Data indicate that AKT promotes EGFR recycling by phosphorylating and activating PIKfyve., Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation., Only a small subgroup of early oral SCC is characterized by EGFR amplification, which can be identified reliably using EGFR-SISH technology. This finding suggests that EGFR gene amplification mostly occurs in advanced stages of oral SCC., EGFR enhances MCM7 phosphorylation and DNA replication through Lyn phosphorylation in human cancer cells., Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer., acquired EGFR and KRAS mutations do not constitute the main mechanism of resistance to anti-EGFR mAb, EGFR is overexpressed during a rare and novel t(7;14) translocation in multiple myeloma., Data indicate that the response rate to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR mutation which was remarkably higher than that in EGFR wild-type patients., Studies indicate that epidermal growth factor receptor (EGFR) T790M mutations is an independent, favorable prognostic factor for predicting surviva, The prevalence of EGFR mutations was 45% with a predominance of deletion mutations in exon 19., CTEN regulates EGFR protein levels through a posttranslational mechanism., EGFR mutations are associated with response to therapy in non-small-cell lung cancer., EGFR mutations are associated with response to therapy in non-small cell lung carcinoma., EGFR mutation is associated with response to treatment in non-small cell lung cancer., EGFR overexpression is associated with the malignant transformation of oral leukoplakia., Data suggest that over-expression of microRNA-133a in breast cancer cells results in down-regulation of EGFR expression; this leads to suppression of phosphorylation of proto-oncogene c-Akt (p-Akt) and inhibition of p-Akt nuclear translocation., Intratumor heterogeneity of EGFR mutations correlates with the distribution of histological subtype in mixed type adenocarcinoma and is associated with smoking history., A reciprocal cross-talk between intrahepatic cholangiocarcinoma cells and myofibroblasts through the HB-EGF/EGFR axis contributes to CCA progression., Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China., Our study revealed various EGFR expression patterns in sinonasal intestinal-type adenocarcinomas, indicating tumor heterogeneity., X-ray crystal structures of the extracellular region of EGFR in complex with three inhibitory nanobodies, elucidating the modes of inhibition., data provide evidence for AnxA2 as a mediator of EGFR endocytosis and signaling in breast cancer via regulation of cofilin activation, Increased EGFR expression is associated with cervical clear cell carcinoma., EGFR-TK inhibitors could cause keratinocytes injury, the release of IL-33 and the consequent interaction with its receptor on mast cells, that induces the secretion of several factors capable to cause skin manifestations, included IL-31, HPV16/18 E6 may contribute in part to EGFR mutations in lung cancer, at least in the Taiwanese population., EGFR mutations were found to be closely associated with the micropapillary predominant subtype., Finally, EGFR-NCE mechanistically depends on EGFR ubiquitination, as the two events can be simultaneously re-engineered on a phosphorylation/ubiquitination-incompetent EGFR backbone., Ron synergises with EGFR to confer certain adverse features in head and neck squamous cell carcinomas., Genetic polymorphisms of epidermal growth factor receptor is associated with response to 5-fluorouracil-based chemotherapy in colorectal cancer., Statistically significant differences were noted in the positive rates of EGFR genetic mutations in non-small cell lung cancer patients between Uygur and Han ethnic groups, with lower positive rates for the Uygur cases., EGFR tyrosine kinase domain gene polymorphisms is associated with gastric cancer., EGFR mutation is associated with response to erlotinib in non-small-cell lung cancer, EGFRvIII and phosphorylated AKT were predictors for the patient survival and clinical outcome., Race was statistically significantly associated with EGFR mutational status in patients with non small cell lung cancer., The results identified Mgat5-mediated beta-1-6-GlcNAc branched N-glycosylation and following activation of EGFR as a potential novel upstream molecular event for PAK1-induced anoikis resistance in hepatoma cells., EGFR mutations are associated with lung cancer., The role of miRNAs in EGFR signalling pathway is fundamental as they target key components of this pathway, and their deregulation is related to the development of a wide range of solid tumours including colorectal cancer. [Review], Expression of p-EGFR was found in this series to be strongly related to increase risk of recurrence and shorter overall survival., EGF & heregulin induced EGFR phosphorylation at Thr-669 & Ser-1046/1047. ERK-mediated Thr-669 phosphorylation suppresses constitutive tyrosine phosphosphorylation in the homo- & heterodimer asymmetric conformations., EGFR, but not ERBB2, is expressed in precursor lesions of squamous cervical neoplasia and is related to the neoplastic progression, Overexpression of epidermal growth factor receptor is associated with rhabdomyosarcomas and drug sensitivity., We conclude that EGFR is upregulated in the hyperplastic alveolar epithelium in all three fibrotic forms of IIPs indicating a potential role during abnormal reepithelization, the EGFR-R521K polymorphisms is not suitable as markers for identifying individuals with a higher risk for developing gastric cancer, LRIG1 inhibits EGFR expression and the downstream signaling activation, interferes with Bcl-2/Topo-2 expressions and eventually sensitizes glioma cells to TMZ, The incidence of EGFR gene mutations in the bone metastases was 75%., HER2 gene amplification and an increased EGFR gene copy number (with balanced chromosome 7 high-polysomy) were each detected in four of 28 (14.3%) salivary mucoepidermoid carcinomas., In preclinical studies, the D2C7-(scdsFv)-PE38KDEL immunotoxin exhibited significant potential for treating brain tumors expressing EGFRwt, EGFRvIII, or both., Network models inferred from the data revealed a conserved set of signaling pathways and RTK-specific features that grouped the RTKs into three distinct classes, Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells., PRL-3-induced hyperactivation of EGFR correlates with increased cell growth, promigratory characteristics, and tumorigenicity in colorectal cancer., Dihydrotestosterone elicits an androgen receptor-dependent acute elevation of [Ca(2+) ]i in HCPSC, most likely by activating EGF receptor signalling., This meta-analysis result suggested that EGFR or HER2 should have significant predictive ability for estimating overall survival in GC patients and may be useful for defining prognosis of GC patients., Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110delta., EGFRvIII mutation is associated with brain tumor., Report atypical teratoid/rhabdoid tumors with high levels of EGFR protein and gene amplification., this study examined whether the inhibition of glucose metabolism using 2DG enhances sensitivity to afatinib in NSCLC cells with EGFR T790M through the regulation of the AMPK/mTOR/Mcl-1 signaling pathway, Epidermal growth factor receptor gene mutations are associated with response to therapy in non-small cell lung cancer., EGFR mutations do not appear to be involved in the development of primary adenocarcinoma of the urinary bladder. A subgroup of cases (36%), however, demonstrated increased gene copy number of EGFR by FISH., malignant breast cancer cells are heterogeneous in their expression of surface-associated CD147 and that high levels of membrane CD147 correlate with cell surface EGFR and CD44 levels, activated EGFR and ERK1, and activated invadopodia., EGFR high expressing cells and tumors investigated in this study are highly dependent on autophagy for growth and survival. Inhibition of autophagy may therefore provide a novel treatment opportunity for EGFR overexpressing tumors, EGFR activating mutations are associated with brain metastases in non-small lung cancer., an important new insight into the modulatory role of CD82 in endocytic trafficking of EGF receptor., Mutation in the EGFR gene is associated with lung neoplasms, EGF receptor signal pathways are activated during cyclopamine-induced radiosensitization in pancreatic cancer cells., Findings support the development of CDK and Raf co-targeting strategies in EGFR/HER-2-overexpressing or RAS/RAF mutant breast cancer (BC)., Report skeletal-related events in advanced lung adenocarcinoma patients with EGFR mutations in whom bone metastasis was present., Report adiponectin levels in non-small lung cancer patients treated with EGFR tyrosine kinase inhibitors., mutation is associated with improved survival time to platinum-based chemotherapy in patients with non-small-cell lung cancer, By hyperactivation of epidermal growth factor receptor (EGFR)., The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients., non-small cell lung cancer patients harboring rare mutations did not show consistent and favorable responses to EGFR TKI compared with those harboring classical mutations, Data suggest that Notch-1 might play a novel role in acquired resistance of non-small cell lung cancer to EGFR inhibitor gefitinib., evaluated mutations in four driver genes, epidermal growth factor receptor (EGFR), Kirsten ras oncogene (KRAS), c-MET, and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), in Chinese lung adenocarcinoma patients, subadditive interaction between EGFR- and AXL-targeted inhibitors across all AXL-positive TNBC cell lines may indicate that increased abundance of EGFR is principally a means to transactivation-mediated signaling., One out of every 6 tumor samples was inadequate for mutation analysis. Patients with EGFR activating mutations treated with EGFR-TKI have the longest survival., There was no statistically significant difference in clinical parameters between patients with EGFR mutations in plasma and those without EGFR mutations., Data provide evidence for the involvement of intron 1 EGFR variants and intron 24 ERBB4 variants in modulating risk for the development of in situ and invasive cervical cancer., non-coding RNA transcription could be the cause and the consequence of CTCF eviction., Results suggest a low frequency of EGFR mutations in BM-NSCLC whereas KRAS mutations are as frequent in BM-NSCLC as in primitive NSCLC., Mutation of the EGFR gene is a positive prognostic marker in completely resected stage I non-small lung cancer, The frequencies of somatic EGFR, KRAS, and ALK gene abnormalities reflect the diverse ethnicity and smoking patterns of non-small-cell lung cancers patients in the United States., calnexin tunes the cellular responses to epidermal growth factor receptor in a manner that depends on the health status of the endoplasmic reticulum, Knock down of TSG101 causes the EGFR to accumulate in low density endosomes., The results obtained through routine analysis of more than 1,300 samples indicated that all types of specimen can be analyzed without any significant bias. TTF-1 immunostaining may be used to predict negative EGFR mutation status., High nuclear to cytoplasmic ratio of EGFR expression is specific for infiltrative glioma., Data indicate that EGFR activity, which was more accurately predicted by the ratio of mitogen-inducible gene 6 (Mig6)/EGFR, highly correlated with erlotinib sensitivity in panels of cancer cell lines of different tissue origins., study found that the frequency of EGFR mutations in lung adenocarcinomas among US Hispanics is similar to the frequency among non-Hispanic whites, EGFR mutation is associated with response to therapy in lung adenocarcinoma., Data suggest subpopulations of lung adenocarcinoma cells containing mutations in EGFR undergo epithelial-to-mesenchymal transition, demonstrate high levels of basal autophagy, resist protein kinase inhibitors, and thrive under hypoxic conditions., They further show that EGFR inhibition can promote an infiltrative invasion front composed of mesenchymal-like cells preferentially in tumors where they are abundant before therapy., A significant correlation between ERCC1 expression and EGFR mutation, and ERCC1-negative patients with exon 19 deletion had a longer progression-free survival than the other patients., Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif., T790M mutation in EGFR is associated with response to therapy in Non-Small-Cell Lung Carcinoma., Exon 19 and 21 mutation in EGFR is associated with response to therapy in metastatic Non-Small-Cell Lung Carcinoma., EGFR mutations are associated with lung adenocarcinoma., G719D+L861R mutation in EGFR is associated with response to therapy in Non-Small-Cell Lung Carcinoma., The expressions of MDR-1, RRM-1, EGFR, ERCC-1 were observed in a variety of pathological types of NSCLC., Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy., We observed EGFR alteration in a subset of cases with operable state gastric cancer and determined that it was associated with an unfavorable prognosis, we obtained noninvasive microPET images of EGFR activity in L858R and E746-A750 del subcutaneous tumor xenografts, but not in subcutaneous tumor xenografts grown form control cell line, EGFR mutation is associated with response to afatinib therapy in lung cancer, Findings identify miR-27a* as a functional star sequence that exhibits novel coordinated regulation of the EGFR pathway., erlotinib and cetuximab treatment was associated with SD >/= six months/PR in five of 20 patients with non-small cell lung cancer (25%), including individuals with squamous histology, TKI-resistant EGFR mutations, and wild-type EGFR, results highlight the importance of EGFR signaling in maintaining skin immune homeostasis and identify a macrophage contribution to a serious adverse consequence of cancer chemotherapy, EGFR signaling in keratinocytes regulates key factors involved in skin inflammation, barrier function, and innate host defense, providing insights into the mechanisms underlying EGFRI-induced skin pathologies., Epidermal growth factor receptor down-regulation triggers human myoblast differentiation., that EGFR IHC does not have value as a marker to predict erlotinib benefit in the first-line maintenance setting for advanced NSCLC, For patients with lung adenocarcinoma harboring activating EGFR mutations treated with EGFR-TKIs, solid predominant subtype is a response predictor for EGFR-kinase inhibitors., aberrantly activated AREG-EGFR signaling is required for CRTC1-MAML2-positive MEC cell growth and survival, suggesting that EGFR-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC., normal CFTR suppresses airway epithelial IL-8 production that occurs via a stimulatory EGFR cascade., Presence of EGFR mutations in patients with lung adenocarcinoma correlates with lower lymph node stage and a greater number of metastatic lesions in the lung and brain., CONCLUSION, The observed benefit of addition of chemotherapy over TKI in EGFR mutation-positive group raises the question, can we offer the therapy of chemotherapy-TKI combination to EGFR mutation-positive lung cancer patients as shown in the present study., EGFR mutation frequency is higher in Indian population vis-a-vis Caucasian population, but lower than that reported in the East Asian population. A significantly higher number of males also harbor EGFR mutations, Geographically there is uniform distribution in the EGFR mutation frequency within India., The study confirms the high expression of the wild-type EGFR in the cutaneous squamous cell carcinoma, in lung adenocarcinomas, KRAS mutations are prevalent in male smokers; EGFR mutations are associated with female sex, nonsmoking and lepidic and micropapillary growth; TTF1 has a role in survival; BRAF mutations have roles in survival, constructed an integrated mathematical model of HER activation and trafficking. Studied HER phosphorylation and abundance data collected in a panel of human mammary epithelial cells expressing varying levels of EGFR/HER1, HER2 and HER3., Data indicate that SOMAmer-based serum EGFR extracellular domain (ECD) assay accurately and specifically measures EGFR in serum., EGFR/HER1 was downregulated in tumour compared to normal tissue, Tyrosine 1045 codon mutations in exon 27 of EGFR are infrequent in oral squamous cell carcinomas., Increase of serum EGFR is associated with acute leukemia., our results could not support the combination use of intermittent erlotinib and pemetrexed in patients with EGFR mutation-negative non-squamous NSCLC., The sole presence of erlotinib was capable of rapidly activate an IGF-1R-dependent, vimentin-enriched mesenchymal-like phenotype in delE746-A750-mutated epithelial cells., We report that respiratory virus-induced EGFR activation suppresses endogenous airway epithelial antiviral signaling., data on EGFR mutation status from a large German cohort of non-small cell lung cancer patients in daily clinical practice are in agreement with data from other populations around the world with regard to associations with gender, smoking habits and TTF1 expression, EGFR mutation analysis by ADx-ARMS was the most sensitive compared to direct sequencing, and provided more reliable EGFR mutation assessments., Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM., EGFRvIII expression can induce miR-520d-3p downregulation and the ensuing upregulation of the transcription factor E2F-1 may lead to drug resistance in hepatocellular carcinoma., NF-kappaB and EGFR may cooperate during intrahepatic cholangiocarcinogenesis and progression. Lymph node metastasis and EGFR positivity were associated with decreases in the survival rate., A feedback loop exists between miR-21 and the EGFR signaling pathway., The small-molecule tyrosine kinase inhibitors erlotinib and lapatinib differentially enhance the dimerization of the various ErbB receptor pairings, with the EGFR/ErbB3 heterodimer being particularly sensitive to the effects of erlotinib, PCN-mediated oxidative stress activates the EGFR-PI3K-AKT/MEK1/2-ERK1/2 MAP kinase signaling pathway, leading to nuclear NRF2 translocation and ARE responsiveness in pulmonary epithelial cells., short K63-linked polyubiquitin chains but not multimonoubiquitin provide an increased avidity for EGFR interactions with ubiquitin adaptors., autoantibodies against EGFR do not seem to be associated with the HER2 gene amplification phenomenon, Our results suggested that LPS increases MUC5AC expression through the TACE/TGF-alpha/EGFR pathway in HIBECs., EGF receptor mutated lung cancers respond better to higher doses of gefitinib and develop resistance later than when a lower dose is employed., EGFR signaling suppresses autophagy via its interaction with Beclin 1 during normal mitogenic signaling as well as during aberrant cell proliferation in cancer cells., T790M mutation is the most prevalent resistance mechanism. The present study did not find any prognostic or predictive roles of T790M mutation in patients with acquired resistance to initial TKIs., Elevated EGFR expression and gene copy number could predict poor survival in head and neck cancer patients., exonic EGFR expression particularly in exon 18 was found to be a relevant predictive biomarker for response to bevacizumab and erlotinib., Report analysis of EGFR mutations in non-small cell lung carcinomas., a mechanism of a probiotic-derived soluble protein in modulating intestinal epithelial cell homeostasis through ADAM17-mediated HB-EGF release, leading to transactivation of EGFR., An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models., Data suggest that patients with advanced solid tumors who exhibit higher-EGFR gene copy number level show longer time to progression of tumors despite chemotherapy with nimotuzumab, monoclonal antibody to EGFR., Molecular expression of MMP-7, laminin c2 or EGFR, and their combinations, may be associated with gastric cancer tumor aggressiveness, Data indicate that the pteridin-7(8H)-one-based inhibitors targeting for both the wild-type and T790M/L858R double mutant EGFRs, as well as potent cellular antiproliferative activities., Simultaneously blocking EGFR, IGF1R and Bcl-xl genes is capable of altering the balance between proliferating versus apoptotic and senescent cells in the favor of both of apoptosis and senescence and, therefore, the tumor cells regression., Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning., EGFR mutations are associated with response to therapy in lung cancer., Different EGFR mutants show differential requirements for dimerization., EGFR expression was correlated with mTOR expression and CD105 (a marker of microvascular density) expression in laryngeal squamous cell carcinoma., the atmospheric electrophile, 1,2-naphthoquinone phosphorylates EGFR, thereby activating the MEK/ERK/AP-1 signal transduction pathway in A549 cells., immunohistochemical EGFR expression appears to be a common feature of penile carcinomas, independently of histologic subtype, histologic grade, and human papillomavirus presence., this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin., Oncogenic activation of EGFRvIII in glioblastoma is likely maintained by a continuous EGFR-EGFRvIII-HB-EGF feedback loop., findings show that autochthonous EGFR-driven lung tumors inhibit antitumor immunity by activating the PD-1/PD-L1 pathway to suppress T-cell function and increase proinflammatory cytokines; these findings indicate EGFR functions as an oncogene through non-cell-autonomous mechanisms, Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3., MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells., Phosphorylated-FAKSer732 was barely detectable during interphase while its levels strongly increased in mitotic cells upon activation of the EGFR/MEK/ERK/CDK5 axis in an integrin-independent manner., Mass spectrometry-based comparison of the phosphorylation profiles of control versus transfected cells revealed a 50-fold decrease in phosphorylation of EGFR Y974 and 1086, with no decrease in Y1173 phosphorylation., Low miR-181a expression is associated with poor survival in patients with colorectal cancer. miR-181a expression might predict PFS in EGFR-targeted therapy., EGFR mutations, including in-frame deletions in exon 19 and base substitutions in exon 21 are associated with esophageal squamous cell carcinoma., The EGFR T790M mutation was identified in 4 (17%) of 24 central nervous system lesions., Positive mEGFR overexpression is associated with decreased survival in resected pancreatic cancer; however, it is not an independent prognostic factor., Mutation of EGFR E21 is negatively correlated with TUBB3 gene expression in non-small cell lung cancer., our findings indicate that EGFR inhibition in GBM induces MET activation in GSCs, which is a functional requisite for GSCs activity and thus represents a promising therapeutic target., 16 tumor samples of NSCLC patients showed no mutation in any of the indicated exons of EGFR1 and k-RAS albeit significant levels of activation or expression of the above-mentined oncogenes., DHA not only displaced several raft-associated onco-proteins, including EGFR, Hsp90, Akt, and Src, from the rafts but also decreased total levels of those proteins via multiple pathways, including the proteasomal and lysosomal pathways, Twenty-eight squamous cell anal cancer patients (34%) showed an increase in EGFR gene copy number due to amplification (4%) or to polysomy (30%)., These results suggest that overexpression of TGF-a through induction of EGFR-MET interaction contributes to cetuximab resistance in colorectal cancer cells., This study has an overall implication for establishing relevance for routine EGFR mutation diagnostics for NSCLC patients in clinics and emphasizes effectiveness for adoption of EGFR inhibitors as the first line treatment among Indian population., Elevated EGFR expression was associated with higher pathologic tumor stages, lymph node metastasis in esophageal squamous cell carcinoma, Found progressive loss of PTEN and increase in EGFR, TGF-alpha, P-AKT expression from benign samples to non small cell lung cancer. Changes were correlated to differentiation extent of cancer tissue, metastasis of lymph nodes and histological classification., The altered dynamics of CD44 in the cell membrane demonstrated a further action of miR-7 in regulating the hyaluronic acid-dependent CD44/EGFR pathway., EGF, EGFRvIII, STAT3 and STAT5 have roles in progression of glioblastoma, Our data suggest that a gastric cancer subtype with EGFR amplification and overexpression benefit from cetuximab treatment., Our findings highlight the importance of the polybasic juxtamembrane sequence in regulating the oncogenic potential of EGFR signaling., the prognostic value and the oncogenic function of NOTCH3 in gliomagenesis, Report EGFR mutations in mammary analogue secretory carcinoma of salivary glands with high-grade transformation., two germline SNPs that associate with somatic mutation of the EGFR pathway, The current meta-analysis showed no evidence for significant association between EGFR 142285G > A polymorphism and breast cancer risk, Global functional profiles show that tumors driven by the EGFR oncogene often display an inflammatory response signature depending on the tissue type., Sorafenib demonstrates clinical activity in non-small cell lung cancer , especially with wild-type EGFR, The effect of LAMC2 on cell growth, cell cycle, migration, invasion, and EGFR signaling in anaplastic thyroid carcinoma cells., EGFR relative overexpression and EGFR amplification were observed, respectively, in 50% and 20% of astrocytomas, while EGFRvIII was only found in GBMs (34.5%, p=0.005)., the present study did not confirm correlations between tissue mRNA levels and protein content of COX-1 and EGFR., EGFR overexpression was observed in 47% of non-small-cell lung carcinoma patients and was significantly associated with squamous cell carcinoma., EGFR-mediated neoplasm resistance to tyrosine kinase inhibitors can be circumvented using interactome mapping., This review will focus on the current (EGFR and KRAS mutations)and future biomarkers in the advanced NSCLC field and also address potential related targeted therapies for these patients., In this review we highlight some potential miRNAs that could be involved in the modulation of the EGF receptor pathway and consequently in Renal cell carcinoma development., EGFR mutation status is highly concordant between the primary non-small cell lung cancer and corresponding brain metastases, MicroRNA expression profile was conducted in a cohort consisted of 128 radically resected NSCLC patients to identify EGFR mutation-related microRNAs and to determine their association with survival., Data indicate that coexistence of EML4-ALK fusion or ALK copy number increase and EGFR, MET, and KRAS mutations in tumor tissue from two treatment-naive Chinese non-small cell lung cancer (NSCLC) patients., Data indicate epidermal growth factor receptor (EGFR)+/tumor-associated trypsinogen inhibitor (TATI)+ patients showed better survival., Overexpression of hMLH1 could be a new molecular marker to predict the response to EGFR-TKIs in NSCLCs., overall genomic and transcriptional landscape of lung adenocarcinoma is affected, but only to a minor extent, by EGFR and KRAS mutation status, Immunohistochemical staining for EGFR, HER2 and IGF-1R was undertaken in 31 ovarian adult granulosa cell tumors. Tumor DNA was also analysed for mutations in the tyrosine kinase domain of EGFR (exons 18-21)., High coexpression of both EGFR and IGF1R is associated with non-small-cell lung cancer., Loss of CDH1 induces EGFR expression via phospho-YBX1, which is activated through the AKT signaling pathway., EGFR D994D polymorphism is associated with less skin toxicity in patients with colorectal cancer receiving antibody against EGFR., EGFR mutation is associated with response to therapy in non-small cell lung cancer., EGFR mutation is not associated with gefitinib resistance in non-small cell lung cancer., 4 genes (EGFR, ERBB2, PTK2, and RAF1) with five SNPs (rs11238349, rs17172438, rs984654, rs11773818, and rs17172432) might be pivotal factors in the development of prostate cancer., HLA-A*0201-restricted T cell epitopes derived from the EGFR T790M mutation have been identified and can be used for immunotherapy to reverse the EGFR T790M-mediated drug resistance., survivin and EGFR expression are useful prognostic markers of triple-negative breast cancer, EGFR overexpression was associated with shortened overall survival, but not disease-free survival in head and neck squamous cell carcinoma, Ectopic expression of EGFRvA in cancer cells conferred a higher invasive capacity than EGFR in vitro and in vivo., this study points to EGFR as a key mediator between CD9-mediated pro-MMP-9 release and cellular invasion of HT1080 cells., an EGFR mutation in exon 19 may have a role in improving survival and prognosis of lung adenocarcinoma after resection, Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-beta receptor signaling pathways contributes to renal fibrosis., DOK2 as a tumor suppressor in EGFR-mutant lung adenocarcinoma, Trafficking of EGFR and Grb2 in living HeLa cells stimulated with low, physiological concentrations of EGFR ligands, was analyzed.., GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells., Hepatocellular carcinoma proliferation, metastasis and production of inflammatory cytokines were regulated via EGF-EGFR signal pathways., Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma, Rare EGFR-mutated non-small-cell lung cancer are heterogeneous, with drug resistance of distal exon 20 insertions and better sensitivity of exon 18 or complex mutations to tyrosine kinase inhibitors., impact of epidermal growth factor receptor (EGFR) expression on prognosis of lip squamous cell carcinoma and its relation to clinicopathological features, Estimate the EGFR mutation incidence Polish non-small cell lung cancer patients., Molecular mechanisms regulating ligand-stimulated EGFR activation, internalization, and post-endocytic sorting. [Review], The GABA signaling is linked to the EGFR pathway and may work through autocrine or paracrine mechanism to promote the castration-resistant prostate cancer progression., EGFR mutations were more frequently in high tumor differentiation., EGFR overexpression and increase in signaling correlates with flotillin-1 expresion., LRIG1 evolved in bladder cancer as a rare feedback negative attenuator of EGFR., Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation., EGFR expression was higher in normal tissues of BRCA1-mutated patients, and was further increased in cancer tissues; EGFR levels were also significantly elevated in ovarian cancer with promoter hypermethylation-mediated inactivation of BRCA1., Complete abrogation of EGFR expression is a critical determinant of the therapeutic improvement induced by the cetuximab-namitecan combination., EGFR expression has prognostic value only for patients with metachronous metastatic CRC., Considering the current knowledge, autophagy inhibition could provide a novel strategy to enhance therapy efficacy in treatment of EGFR deregulated tumors, Data suggest that combined inhibition of epidermal growth factor receptor and sphingosine kinase-1 has potential as an anticancer therapy in triple-negative breast cancer in which insulin-like growth factor-binding protein-3 expression is high., Overexpression of EGFR is associated with sinonasal adenocarcinoma., these results support a cooperation of ErbB1, ErbB4, and members of the MMP family in predicting OSCC invasion and poor clinical outcomes., Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells., findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression, We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sorting and lysosomal degradation of the EGFR., direct sequencing overlooked EGFR mutation in a significant number of lung adenocarcinoma patients, We show that Tay bridge antagonizes EGFR signalling in the Drosophila melanogaster wing disc and other tissues, and that the protein interacts with both Erk and Mkp3, These results suggest that co-inhibition of ROS1 and EGFR may be an effective strategy to combat resistance to targeted therapy in some ROS1 fusion-positive non-small cell lung cancer patients., Propranolol restricts the mobility of single EGF-receptors on the cell surface before their internalization., EGFR mutations are higher in all types of NSCLC, 19-del and L858R are two of the more frequent mutations in Chinese patients., Analysis of the A763_Y764insFQEA mutant indicates that the inserted residues shift the register of the C helix in the N-terminal direction, altering the structure in the region that is also affected by the tyrosine kinase inhibitor-sensitive EGFR-L858R., The rapid degradation of activated EGFR in AnxA6-depleted invasive tumor cells underlies their sensitivity to EGFR-targeted inhibitors., Report intratumoral distribution of EGFR-amplified and EGFR-mutated cells during the developmental process of lung adenocarcinoma., ligand in the milieu of EGFRvIII-expressing GBM cells is likely to influence the EGFRvIII-Met interaction and resistance to treatment, and highlights a novel antagonistic interaction between EGFRwt and EGFRvIII in glioma cells, our data suggest that castPCR is highly sensitive and specific to detect EGFR mutations in non-small-cell lung cancer clinical samples., Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation., Toxoplasma gondii activates EGFR to prevent autophagy and killing of the parasite., A high frequency of somatic mutations in p53 (44.3%; 43/97) and/or EGFR (51.5%; 50/97) resulted in a high discrimination rate of tumor clonality (77.3%; 75/97) in metachronous multiple lung cancers., Lung adenocarcinoma patients with an EGFR T790M mutation showed a more favorable prognosis., EGFR mutations are associated with non--small-cell lung cancer., Report significant genotype-phenotype correlations between EGFR mutations and adenocarcinoma histologic subtypes and TITF-1/SP-A expression., EGFR mutation is associated with lung cancer., EGFR and KRAS mutations are not uncommon in biliary tract carcinomas, The EGFRvIII-STAT3 pathway promotes cell migration and invasion by upregulating S100A11 in hepatocellular carcinoma., augmentation of proinflammatory chemokines CXCL1/2, by potentiating NF-kappaB activation through EGFR-transactivated Akt, contributes to CXCR2-driven ovarian cancer progression, Epidermal growth factor receptor mutation is associated with non-small cell lung cancer, the significant somatic EGFR alterations/mutations in lung adenocarcinoma (Review), These results suggest that EMMPRIN mediates EGFR-induced tumorigenicity and that combined targeting of EMMPRIN and EGFR may be an efficacious treatment approach., results suggest that the dual blockade of mutant EGFR and Met by crizotinib and a new generation EGFR-TKI may be promising for overcoming resistance to reversible EGFR-TKIs but careful assessment is warranted clinically., EGFR mutation is associated with response to chemotherapy in lung adenocarcinoma., An uncommon insertion mutation in exon 19 of EGFR is associated with response to chemotherapy in lung adenocarcinoma., EGFR mutation is associated with squamous cell lung carcinoma., EGFR was activated in colonic macrophages in patients with ulcerative colitis., EGFR mutation ratios in primary tumors and metastatic tumors are different in lung adenocarcinoma., The suppression of K-ras expression by siRNA interfered with this synergism and inhibited both EGFR and Akt activity in A549 cells., in this work, we identified TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-kappaB and STAT3 pathways for lung cancers harboring mutant EGFR, this report have defined a novel network leading to ERK1/ERK2 activation in cysticfibrosis airway epithelial cells in response to P. aeruginosa that involves both the TPL2 and EGFR protein kinases and contributes to inflammation of CF airways., EGFR mutation was a rare event in triple-negative breast cancers, but high EGFR copy number including EGFR amplification and high polysomy was relatively frequent and correlated with EGFR overexpression., Wild-type EGFR versus mutated EGFR was associated with early progression. The presence of abdominal metastasis was independently associated with early progression in metastatic non-small-cell lung carcinoma receiving EGFR-TKI., The results indicate that ADAM17 mediates Ang II-induced EGFR transactivation on hepatic stellate cells, and that this process may participate in the progression of liver fibrosis, A novel role for Ack1 in diverting activated EGFR into a non-canonical degradative pathway., we report that Huh-7 cell line is an easy source for the particular gene of human epidermal growth factor isolation and we are also suggesting P. pastoris is an expression system to produce recombinant human epidermal growth factor, EGFR mutations are associated with advanced non-small-cell lung cancer of adenocarcinoma in Asian patients., EGFR G719X and L861Q mutations are associated with response to therapy in non-small-cell lung cancer., EGFR mutation is associated with brain metastasis in pulmonary adenocarcinomas., EGFR mutations are associated with response to therapy in non-small-cell lung cancer., EGFR exon 19 insertions is associated with response to gefitinib in lung cancer., Lung adenocarcinomas with EGFR exon 20 insertion mutations were present in a considerable proportion of patients, had distinct clinicopathologic characteristics, and had different pathway activation patterns compared to classic EGFR activating mutations., our study shows that in triple negative breast carcinomas EGFR is frequently amplified without mutation but is overexpressed, The EGF receptor (EGFR) regulator MIG6 and the apoptosis regulator BIM., Binding of the HSV-1 envelope initiates the epidermal growth factor receptor EGFR-PI3K signaling pathway, which leads to virus-induced early cofilin phosphorylation and F-actin polymerization., The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor., First-line afatinib significantly improves progression-free survival with a tolerable and manageable safety profile in Asian patients with EGFR mutation-positive advanced non-small cell lung cancer., ALK rearrangements and EGFR mutations could coexist in a small subgroup of NSCLC., Mechanistic model of EGFR endocytosis to determine the relative contributions of three parallel pathways of MIG6, ubiquitin ligase CBL and Sprouty2., The regulation, function and formation of EGFR complexes. [Review], High EGFR gene copy number is associated with non-small cell lung cancer., this is the first reported case to our knowledge of a patient with both a possible germline EGFR T790M mutation and a somatic PIK3CA mutation., EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms, EGFR protein expression and high polysomy on chromosome 7 are frequent abnormalities in adrenal cortex carcinomas., Major EGFR mutations and adenocarcinoma histology are independent predictors of better treatment outcome in patients with EGFR-mutant non-small cell lung cancer., IGF1R activation is a molecular mechanism that confers acquired resistance to erlotinib in lung cancers with the wild-type EGFR, using high CEA level to predict EGFR mutations seems to be more sensitive than using EGFR mutations in plasma, DSC MRI perfusion may have a role in identifying patients with EGFR gene amplification and EGFRvIII gene mutation status, potential targets for individualized treatment protocols., Frequencey of baseline EGFR T790M mutations and correlation with poor response to EGFR inhibitors in lung cancer., In NSCLC patients, positive EGFR mutation status may be associated with longer VDT, which seemed to have a slowly progressive and less-aggressive character., hot spot mutations are associates with Merkel cell polyomavirus infection, Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma., BCL2L11 mRNA expression is a biomarker of survival in EGFR-mutant NSCLC and can potentially be used for synthetic lethality therapies., A gene polymorphism with lung cancer was found, and EGFR Short genotype of cytosine adenine repeat number polymorphism was significantly associated with an increased risk of lung cancer. [review], SR48692 may inhibit non-small cell lung cancer cell proliferation in an EGFR-dependent mechanism., ADCC-dependent killing of EGFR(+) A431 cancer cells., In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling, Data suggest that detection of IgG responses to epidermal growth factor receptor (EGFR)-derived peptides may be a promising method for prognostication of NSCLC patients receiving gefitinib., These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the activation of cyclin D1 by LMP1 in the carcinogenesis of NPC., Weak power frequency magnetic field acting similarly to EGF stimulation, induces acute activations of the EGFR sensitive actin cytoskeleton motility in human amniotic cells., Patients with a higher level of PDGFR-alpha and EGFR expression were found to have a significantly poorer prognosis than those with lower PDGFR-alpha and EGFR expression., Curcumin increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells., study aimed at prospectively estimating the impact of EGFR intron 1 (CA)n variants on clinical outcome in KRAS exon 2 and BRAF wild-type chemo-refractory metastatic colorectal cancer patients, Data indicate that cucurmosin can down-regulate epidermal growth factor receptor (EGFR) protein expression, but not at the messenger RNA level., A sharp or extremely sharp increase in EGF blood plasma level with pronounced EGFR expression in complex endometrial hyperplasia (without atypia) is likely to indicate poor prognosis that may lead to the transformation into atypical form., In Malaysian patients with non- small cell lung cancer, the EGFR mutation rate was similar to that in other Asian populations., Incidence of metastatic bone disease and brain metastases was not different between EGFR+, KRAS+ and WT patients, Tissue kallikrein facilitated the activation of EGFR, ERK1/2 and p38 cascade. Not p38 but ERK1/2 phosphorylation was severely compromised in cells depleted of EGFR. Impairment of signaling of ERK1/2 seemed not to be restricted to EGFR phosphorylation., Identify a molecular signature based on levels of pEGFR, pERBB2, and SMOX for the initiation of gastric carcinogenesis in helicobacter infected gastric epithelial cells., PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor., EGFR activation is involved in the downregulation of miR-145 in lung cancer cells, A glioma classification scheme based on coexpression modules of EGFR and PDGFRA., FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations., EGFR gene amplification/overexpression may be involved in carcinogenesis of the cervix and may be an early event during carcinogenesis., The majority of SDCs express AR, HER2, and/or EGFR., A dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptor (EGFR)/HER2., NE induces myocardial hypertrophy and up-regulates GDF-15, and this up-regulation of GDF-15 negatively regulates NE-induced myocardial hypertrophy by inhibiting EGF receptor transactivation following NE stimulation., Activation of EGFR in response to diesel exhaust particles mediates the inflammation response in bronchial epithelial cells., Although the sensitive pyrosequencing method was used, no EGFR, KRAS or BRAF mutations could be found, Our results suggest that immunohistochemical analysis with mutation-specific antibodies is a promising approach for quantifying EGFR mutations, and may predict the effect of EGFR-TKI treatment for EGFR mutation-positive NSCLC., EGFR mutation is associated with lung cancer., genetic association study in population studied at academic medical center in Chicago, Activating mutations of EGFR were observed in 28.6% of adenosquamous lung carcinoma patients and included deletions of 15 base-pairs in exon 19 in three cases and substitution of L861Q with coexistence of G719X mutation in one non-smoking male patient., the expression of epidermal growth factor receptor was modulated by MUC4., The EGFR PCR test result was confirmed by a sensitive deep sequencing assay., Data indicate an important role for epidermal growth factor receptor (EGFR) in regulating the expression of complement components and complement activation in epidermis and keratinocytes., EGFR exon 19 deletions were associated with lung cancer., In prostate cancer, EGFR mutations occur more commonly than KRAS mutations and EGFR and KRAS mutations may be mutually exclusive, In this cetuximab-treated colorectal cancer population, EGFR gain was associated with better outcome and PTEN protein expression with longer TTP in KRAS WT, KRAS WT/AREG high and KRAS/BRAF WT subpopulations., EGFR expression and Ki67 labeling index correlate with grade of meningioma [P < 0.0001 and P < 0.0001 respectively] and are statistically significant, whereas p53 expression does not correlate., Data suggest that epidermal growth factor receptor vIII mutant (EGFRvIII) positivity is not a major negative prognostic factor in glioblastoma patients treated according to current standards of care., Findings suggest that MET may be a therapeutic target in TNBC and that the combined therapy targeting MET and EGFR may be beneficial for the treatment of triple-negative/basal-like breast cancer (TNBC/BLBC)patients., Data suggest that overexpression of CK2a (casein kinase 2, alpha) in liver promotes oncogenesis by mediating EGF/EGFR- (epidermal growth factor/EGF receptor)-induced HDAC2 (histone deacetylase 2) expression in hepatocarcinogenesis., miR-608 and miR-34a regulate chordoma malignancy by regulating EGFR, MET and Bcl-xL, Overexpression of EGFR is associated with gastric adenocarcinoma., Cetuximab-mediated antibody-dependent cell-mediated cytotoxicity activity may be correlated with the cell surface expression level of EGFR, regardless of the mutational statuses of KRAS and BRAF, in colorectal cancer., Presence of variant forms of EGFR polymorphisms leads to a better breast cancer prognosis in Brazilian women with unilateral breast cancer and no distant metastases., Expression of S100A9 and EGFR closely correlates with cisplatin chemoresistance in bladder cancer., High frequency of genetic mutations in EGFR, p53, and KRAS resulted in a high discrimination rate of synchronous multiple small adenocarcinoma clonality., KLK6 promotes the proliferation of lung tumoral cells and restrains their apoptosis in vitro via ligand-dependent EGFR and was dependent on the protease-activated receptor 2., Data indicate that metformin reverses epithelial-mesenchymal transition and decreases interleukin-6 signaling in EGFR-TKI-resistant lung cancer cells., Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking., Of the 132 laryngeal squamous cell carcinoma specimens examined, only 1 specimen was found to be positive for EGFR exon 20 mutation, 2 specimens were positive for EGFR exon 21 mutation, and no samples were found to be positive for EGFR exon 19 mutation., DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway., AUthors identify EGFR as a molecular target to overcome a novel mechanism of radioresistance in KRAS-mutant tumor cells., this is the first report to demonstrate that miR-566 expression is significantly increased in glioma cells and modulated the EGFR pathway through direct targeting of VHL, High EGFR gene expression levels were associated with lymph node metastases in advanced gastric cancer., Over-expression of EGFR is closely correlated to poor prognosis in Tunisian patients with non-small cell lung adenocarcinoma., No statistically significant differences were observed in levels of EGF Receptor protein, when comparing breast cancer biopsies from male and female patients., Combined inhibition of DRD2 and Epidermal Growth Factor Receptor (EGFR) led to synergistic tumoricidal activity as well as ERK suppression in independent in vivo and in vitro glioblastoma models., Low protein expression of p-Akt308 was associated with improved DFS and OS among patients treated with hormonal therapy following adjuvant chemotherapy. Coexpression of EGFR and p-mTOR was associated with worse OS., An EGFR/HER2-Bispecific and enediyne-energized fusion protein shows high efficacy against esophageal cancer., EGFR-mediated activation of the downstream effectors ERK1/2 in pSS SGEC appeared to require ADAM17-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR., Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer., Cx43 in Temozolomide (TMZ) resistance occurred by TMZ-resistant glioblastoma cells being able to activate epidermal growth factor receptor., EGFR transphosphorylation at Y845 plays an important role in its autophosphorylation and kinase activity., patients with mutated EGFR had more lung, brain, and bone metastases, and bone metastasis was an independent negative predictor of OS., Patients with secondary T790M mutation at the time of progression having gradual or local progression after acquired resistance to EGFR-TKI benefit more from EGFR-TKI treatment beyond progression compared to those without T790M mutation., Data suggest that up-regulation of TGFA (transforming growth factor alpha)/EGFR signal transduction activates transcription factor NFkappaB resulting in up-regulation of expression of ICAM1 (intercellular adhesion molecule 1) in osteosarcoma cells., These results might suggest a novel combined EGFR-autophagy modulation strategy, to overcome intrinsic glioblastoma radioresistance., Study shows that EGFR is a putative Linc00963 target in prostate cancer cell lines., High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival or recurrence-free survival., EGF/EGFR axis triggers epithelial-mesenchymal transition in cholangiocarcinoma cells highlighting the key role of this pathway in CCA progression, these findings suggest that EGF/EGFR signaling activates downstream PI3K/Akt to induce FoxO1 nuclear exclusion, which activates MMP9 to promote NSCLC invasiveness, Can attenuate both protein and mRNA expressions of EGFR., Data indicate that liver epidermal growth factor receptor (EGFR) expression is down-regulated before and during regeneration in liver steatosis., Computational design of binding proteins to EGFR domain II., IFNgamma and TNFalpha induced the phosphorylation of EGFR and the following phosphorylation of ERK, which is partly responsible for the suppressive effect of IFNgamma on TNFalpha-induced production of CTACK/CCL27., in the study, 81.39% of head and neck squamous cell carcinomas(HNSCC) had 4 mutations, In the title., surface up-regulation of NKG2D ligands by human epithelial cells in response to ultraviolet irradiation, osmotic shock, oxidative stress, and growth factor provision is attributable to activation of the epidermal growth factor receptor., No association of beclin 1 with EGFR mutation was found (P > 0.05) in non-small cell lung cancer., Compound 3, now renamed CO-1686, is currently in a phase I/II clinical trial in patients with EGFR(mut)-advanced NSCLC that have received prior EGFR-directed therapy., Activation of sperm EGFR by light irradiation is mediated by reactive oxygen species., Report efficacy and toxicity of afatinib in the EGFR-TKI pre-treated population in routine clinical care., Induced an EGFR/IKKalpha/beta/NF-kappaB pathway., these results suggest that Ptn-induced Akt/Erk activation and some of its pleiotropic functions are mediated by EGFR trans-activation in cultured osteoblasts., EGFR gene T790M mutations are associated with lung cancer., EGFR mutation is associated with treatment response in non-small-cell lung cancer., Germline EGFR T790M mutation is associated with metastasis in lung adenocarcinoma., EGFR exon 19 insertions are sensitive to gefitinib treatment in lung cancer., In lung adenocarcinomas, positive and partial positive TTF-1 expression has a significant positive correlation with EGFR mutations(exon 19 and 21)., EGFR cytoplasm staining has no link with poorer outcome; it is even more related to better prognosis. EGFR heterogeneity of staining correlated with more aggressive tumors, and is an important marker of poor prognosis in vulvar squamous cell carcinoma., Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance., Our project proposed a novel function of EGFR in the regulation of glucose metabolism in chondrosarcoma cells and contributed to the development of therapeutic strategies for the clinical treatment of chondrosarcoma patient, EGFR mutation is associated with treatment efficacy in non-small cell lung cancer., EGFR and the T790M mutation have roles in non-small-cell carcinoma with squamous histology [multiple case reports], This may have profound implications for the anti-estrogen treatment of ER-positive breast cancers that have increased levels of EGFR., No significant associations were found among GNAS1 T393C polymorphism and therapeutic efficacy of tyrosine kinase inhibitor in advanced non-small cell lung cancer with unknown EGFR mutation., Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor., To study the prognostic factors influencing survival after recurrence, EGFR mutations were prospectively evaluated in 594 patients who underwent curative surgical resection for pulmonary adenocarcinoma., EGFR mutation detection is associated with non-small cell lung carcinoma., Lung adenocarcinoma with morule-like components is a distinct unfavorable prognostic and predictor for EGFR mutation., EGFR/oncogene-driven cancers evolve during the course of the disease especially during targeted treatment., Mutational analysis of the EGFR gene in plasma samples is feasible with allele-specific PCR assays and represents a non-invasive supplement to biopsy analysis, Our data suggest a role for EGFR in DNA repair independent of DNAPKcs but dependent on ERCC1., Muller cells express the alpha2A-adrenergic receptor, and brimonidine triggers both Src-kinase- and matrix metalloproteinase-mediated autocrine ligand-dependent activation of epidermal growth factor receptors on Muller cells., EGFR/p53 mutations were associated with lung adenocarcinomas tumor size >1 cm. EGFR mutation was a predictor of EGFR TKI response in relapsed patients., an in vivo xenograft assay indicated that WK88-1 markedly suppressed tumor growth in the H1975 xenografts, highlighting the potential efficacy of WK88-1 for overcoming gefitinib resistance in NSCLCs harboring the T790M mutation in EGFR., EGFR mutation is associated with drug resistance in non-small cell lung cancer., These data reveal the distinct roles of EGFR and HER2 on expression of matrix macromolecules in cancer cells., EGF-induced expression of HIF-1alpha and its targets, vascular endothelial growth factor (VEGF) and BNIP., PS detection of low-frequency mutations may improve the KRAS predictive value for EGFR therapy selection., new class of protein cancer biomarker candidates, Aromatase is a candidate prognostic factor in patients with lung adenocarcinoma, especially in those with EGFR mutations, and may also be a beneficial therapeutic target in those patients., the high migratory activity of investigated pancreatic cancer cell lines is due to autocrine EGFR activation and possibly of other receptor tyrosine kinases, miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in epithelial ovarian cancer cell lines, In OSCC, EGFR (E746-A750del) expression was found not to be associated with clinicopathological characteristics, prognostic factors, or social habits. HPV does not appear to be relevant to the survival of patients with OSCC., To investigate whether functional polymorphisms of EGFR and its ligands genes (EGF and TGFA) were associated with ILD., Data suggest that FccR and EGFR CA repeat polymorphisms may be associated with the outcome of metastatic colorectal cancer patients treated with cetuximab and FOLFIRI., We show the occurrence of EGFR mutations in patients with occupational asbestos exposure and also in those diagnosed with chronic obstructive pulmonary disease who have not been often investigated before., EGFR inhibitors suppressed keratinocyte expression of hBD2 and 3 induced by S. epidermidis., Trp53 haploinsufficiency and EGFR overexpression cooperate in vivo to significantly increase neurofibroma and induce grade 3 peripheral nerve sheath tumorigenesis, revealed that CKAP4 could associate with EGFR at basal status and the complex was reduced upon EGF stimulation, leading to release EGFR into cytoplasm, Loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling in prostate cancer., Data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells., Results show that minor EGFR T790M mutations were present in 13% of EGFR-TKI-naive surgically resected lung adenocarcinomas and were associated with drug-sensitive EGFR mutations., EGFR activation is regulated by integrin beta-1. Decreased Itgb1 leads to decreased EGFR activation., Data demonstrate that JAK2/STAT3 signaling is essential for EGFRvIII-driven migration and invasion by promoting focal adhesion and stabilizing the EGFRvIII/JAK2/STAT3 axis., study was to address whether the ERBB3 mutations altering Val-104 were present in homologous amino acids of ERBB family genes EGFR, ERBB2 and ERBB4 in CRC., EGFR and KRAS mutations were present in adenocarcinoma of the lung but not squamous tumors., Data show that overexpression of miRNA-181c in A-172 glioblastoma cells inhibited matrix metalloproteinase-9 (MMP9) expression by inhibiting Akt phosphorylation, but not phosphorylation of epidermal growth factor receptor (EGFR) receptor., Egfr is significantly overexpressed in intrahepatic cholangiocarcinomas., In a cohort with non-small cell lung cancer, the mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with both in 3.81%. Mutation was more common in non-smokers than smokers, and in adenocarcinoma more than squamous cell carcinoma., There were no clearly pathogenic mutations in the EGFR gene in a cohort with thymic tumors., Results demonstrated that the SPACE-HRM system we set up is a high sensitive assay that can be used for EGFR and KRAS allele enrichment and reliable detection, Overexpression of EGFR was more observed in esophageal squamous cell carcinoma than in the control group. Overexpression of EGFR in ESCC tissues might play an important role in carcinogenesis and the progression of ESCC., The unpredictable variability in EGFR CN and therefore in EGFR wild type/mutant allelic ratio justifies the implementation of sensitive methods to identify patients with EGFR mutated tumors, EGFR mutation is associated with response to therapy in lung adenocarcinoma., EGFR mutations were found in 2.8% of lung adenocarcinomas with nodular ground-glass opacity., Results suggest that WEB2086 and AG1478 are synergistic in ovarian cancer cells with high expression of both platelet-activating factor receptor (PAFR) and epidermal growth factor receptor (EGFR)., Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent resistance to lapatinib in breast cancer., EGFR played an important role in docetaxel-resistant prostate cancer cells., Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non-small-cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage., we present the results of detecting EGFR mutations in individual sample types using three different low- or high-sensitivity techniques., we validated our method to successfully define tumor cell subpopulations containing distinct genetic and treatment resistance profiles and potentially mutually cooperative combinations of alterations in EGFR and other genes., Lactobacillus rhamnosus GG-derived protein p40-stimulated activation of EGFR mediates up-regulation of mucin production, which may contribute to the mechanisms by which p40 protects the intestinal epithelium from injury., The surface levels of three receptors [TfR, epidermal growth factor receptor (EGFR) and beta1 integrin] were tested and found to be reduced dependent on Escherichia coli EspG translocation., low rate of EGFR and KRAS mutations in this Belgian HNSCC population suggests that these genes will probably not play a major role in predicting response to anti-EGFR therapy in HNSCC, LL-37 induced TACE and EGFR activation, as well as TGF-alpha and MUC5AC mucin production by NCI-H292 cells., The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma., In early enteropathogenic Escherichia coli infection EGFR phosphorylation contributes to host cell survival. EspF-driven caspase activation and consequent EGFR loss likely induce a precipitous increase in host cell death later in the infectious process., Tumors from NSCLC patients with EGFR-activating mutations that were intrinsically resistant to EGFR-TKIs expressed higher levels of CRIPTO1 compared with tumors from patients that were sensitive to EGFR-TKIs., Computation biology data showed that EGFR and MET drive the cancer pathways in glioblastoma individuals., A prevalence of EGFR mutations in small cell lung cancer is rare, and occurs most frequently in females and nonsmokers., High EGFR expression is associated with non-small cell lung cancer., EGFR mutations are associated with lung adenocarcinomas., The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation, EGFR signaling regulates the global metabolic pathway in EGFR-mutated LAD cells., SNPs were found in exon 20 of the EGFR gene in thyroid carcinoma showing thymus-like elements., Epidermal Growth Factor Receptor P753S Mutation is associated with responsive to chemotherapy in cutaneous Squamous Cell Carcinoma., analysis of a mathematical model for how EGFR demonstrates linear signal transmission, EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China., The association between EGFR gene copy number, KRAS status, and anti-EGFR antibody response in colorectal cancer cell lines, was evaluated., EGFR plays an integral role in establishing the cellular context necessary for successful pregnancy via the activation of intricate signaling and transcriptional networks, thereby providing valuable insight into potential therapeutic targets., EGFL7 enhances EGFR-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells., Findings suggest that adding chloroquine to EGF receptor (EGFR) and AKT2 inhibition has the potential to improve tumor responses in EGFR M+ non-small cell lung cancer (NSCLC)., Cetuximab activity in NSCLC patient-derived xenograft models was demonstrated clearly only in tumors that expressed high levels of EGFR, as defined by an IHC score of >/=200., The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway., KRAS codons 12 and 13 mutation status was the first validated molecular biomarker for anti-EGFR antibodies, BK-mediated angiogenesis in endothelial cells involves the induction of the expression of VEGF associated with the activation of the NO/EGF-R/p21Ras/ERK1/2 MAP kinases signaling pathway, The frequency of EGFR mutation was adenocarcinoma in situ (62%), minimally invasive adenocarcinoma (60%), lepidic (77%), acinar (49%), papillary (50%), solid (28%), micropapillary (43%), and invasive mucinous adenocarcinoma (0%)., Data indicate that combination of epidermal growth factor (EGFR) inhibitors with either the phosphatidylinositol 3-kinases inhibitor ZSTK474 or the mTOR serine-threonine kinases inhibitor sirolimus showed increased activity., EGFR testing is requested in Israel routinely for all advanced NSCLC patients, regardless of histology. In most cases, systemic treatment is deferred until the results of this test are received., longer Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors use and skin rash were significant factors predictive for gefitinib antitumor activity, Report EGFR overexpression and ERK1/2 overexpression in Kazakh patients with esophageal squamous cell carcinoma., Suggest that EGFR gene amplification is associated with the severity of cytologic findings in cervical neoplasms., Activation of EGFR mutations identified in PT., The EGFR exon 19 and 21 coding sequences did not show any mutations., Ten patients with metastatic non-small cell lung cancer harboring an activating epidermal growth factor receptor mutation were included in this prospective observational study, Decay-accelerating factor CD55 tumor expression is a pivotal determinant of anti-EGFR-IgG3-triggered complement-mediated lysis, forcing a switch from classical complement pathway activation to C1q-dependent alternative pathway amplification., The frequency and characteristics of EGFR gene mutation in Turkish non-small cell lung cancer patients, Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein., our data suggest that miRNA-34 inhibits EGFR signaling to regulate MMP7 expression in gastric carcinoma, EGFR and PTGS2 expressions are prognostic molecular biomarkers correlated with clinical variables in colorectal cancer liver metastases., Overexpression of EGFR predicts poor outcomes of medulloblastomas, small cell glioblastomas and primitive neuroectodermal tumors, In this review ERBB and neuregulin signal pathway genes are associated with neuropsychiatric diseases, such as schizophrenia and bipolar disorder., In advanced non-small-cell lung cancer, folate receptor alpha (FRA) and EGFR are frequently coexpressed, but FRA and EGFR protein levels did not statistically correlate with each other, EGFR or KRAS mutations were detected with xTAG liquidchip technology, Cases with ErbB pathway mutations have a worse outcome., tissue stiffening promotes GBM proliferation by spatially and biochemically amplifying EGFR signaling, Results suggest that decreased cell-cell adhesion and EGFR activation are drivers of cellular migration in epithelial cells., Data showed that miR-203 levels were inversely correlated with the expression of two EGFR ligands, EREG and TGFA, and an EGFR dependent gene signature., The mutant allele frequency may be a potential predictive factor of tyrosine kinase inhibitor treatment efficacy in patients with lung adenocarcinoma carrying the L858R mutation of the EGFR., High expression of PD-L1 was associated with the presence of EGFR mutations in surgically resected NSCLC and was an independent negative prognostic factor for this disease., expression of EGFR, CDKN2A and TP53 may be associated with tumour pathology but is not induced by HPV, In tDNA, 50 mutations (36 EGFR, 5 ERBB2, 4 KRAS, 3 BRAF, and 2 PIK3CA) were identified, of which 26 were detected in cfDNA. These data demonstrate the feasibility and potential utility of mutation screening in the detection of a range of tumor biomarkers, in EGFR mutation positive NSCLC patients treated with erlotinib a low number of CA repeats in intron 1 of the EGFR gene is a predictor for both longer progression free survival and overall survival., We sought to investigate whether mucinous features, such as signet-ring cell feature and extracellular mucin, are associated with EGFR and KRAS mutations in patients with lung adenocarcinoma, Serum 25-hydroxyvitamin D levels correlate with EGFR mutational status in pulmonary adenocarcinoma, These results demonstrated that the evaluation of GPER1, EGFR and CXCR1 expression in papillary thyroid carcinoma may be useful in predicting the risk of lymph node metastasis, Current approaches for predicting a lack of response to anti-EGFR therapy in KRAS wild-type patients., the frequency of detected cytogenetic aberrations MYC/MYCN, EGFR and PDGRFA, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene, pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults., TrkB-EGFR-sortilin (TES) complex in exosomes has a function in the activation and migration of endothelial cells., The treatment with EGFR inhibitor in combination with non-surgical combined modality in patients with hypopharyngeal carcinoma was well tolerated and resulted in encouraging laryngeal preservation survival rate., preliminary data suggest that SNP-216 polymorphism of the EGFR gene could be useful in predicting colorectal tumor response and the appearance of severe skin rash might also be associated, EGFR mutations in advanced NSCLC may be associated with higher ORRs to chemotherapy, but may have nothing to do with PFS and OS., This advancement represents a key step towards sensitive wide-field Raman endoscopic imaging of multiple biomarkers for early and accurate diagnosis of EGF receptor-expressing tumors of different internal organs., Oncogenic EGFR upregulated mir31 in lung carcinogenesis., Studies indicate the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway in breast cancer., Data suggest that expression of EGF, EGF receptor, and c-erb-B2/ERBB2 in gastric mucosa is up-regulated during (1) gastritis with Helicobacter pylori infection, (2) gastric cancer, and (3) gastric cancer with Helicobacter pylori infection., High EGFR gene copy number or activating EGFR mutations may identify patient subgroups who receive increased clinical benefit from vandetanib in combination with docetaxel in second-line non-small cell lung cancer, The V843I mutation contributes to tumorigenesis by promoting phosphorylation of EGFR and its downstream signaling proteins. This mutation also appears to provide resistance to EGFR-TKIs through structural modification of EGFR., The expression of microRNA-200c in primary glioblastoma multiforme patients correlates with the level of EGFR amplification., Positive EGFR mutations were shown to be associated with a better response to Docetaxel previously treated with a Paclitaxel-Platinum doublet for the treatment of Non-Small-Cell Lung Cancer in the Mexican population., phosphorylation of DCBLD2 Y750 recruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of AKT, thereby enhancing EGFR-driven tumorigenesis, Presented data suggest that the transient formation of dynamic PTPD1/EGFR signalling complexes strengthens EGF signalling by promoting the spatial propagation of EGFR phosphorylated species, Demonstrate the essential role of EGFR/Akt/IkappaBbeta/NF-kappaB pathway in the inhibitory effect of PA-MSHA on invasion and metastasis of HCC through suppressing EMT., The results of this study provide detailed structural insights and emphasize the important binding features of these compounds, which may assists in the design and development of novel EGFR inhibitors., Increased expression of SOS1 increases NFkappaB activation in several types of cancer cells, and ablation of SOS1 inhibits EGF-induced NFkappaB activation in these cells, indicating that SOS1 is a component of the pathway connecting EGFR to NFkappaB activation., These increases in effector communication by cell surface receptors resulted in an increase in EGFR ubiquitylation with sustained ligand incubation., Selective HSP90 blockade by ganetespib represents a potentially important complementary strategy to targeted TKI inhibition alone for inducing substantial antitumor responses and overcoming resistance, in both the mutant and WT-EGFR settings., The results suggest that considering IDO and EGFR as two indicators for breast cancer treatment or prognosis analysis provides a potential option of individual treatment for the portion of breast cancer patients with co-expression of IDO and EGFR., In human coronary vascular smooth muscle, uPA induces uPAR-independent, domain-dependent smooth muscle cell proliferation through transactivation of EGFR by a plasmin-mediated, ADAM-induced, and HB-EGF-dependent process., EGF receptor response to different ligands may result from partial agonism for dimer formation, differences in the kinetic pathway utilized to generate activated receptor dimers, and biases in the formation of heterodimers versus homodimers., EGFR gene mutations occurred more frequently in adenocarcinoma patients particularly with accompanying expression of TTF1 in non-small cell lung cancer., Molecular docking simulations study revealed the genetic basis for EGFR drug resistance towards gefitinib and the ways for its reversal., EGFR mutation is associated with non-small cell lung cancer., Overexpression of EGFR is associated with ameloblastoma., EGFR mutation is associated with treatment response in non-small-cell lung cancer., HDAC6 inhibits rabaptin-5-mediated early endosome fusion in gastric cancer and therefore sustains growth stimulation by prolonging the activation of EGF receptor, PKP2 is a novel activator of the EGFR signaling pathway., Expression of EGFR and other markers were compared in primary squamous cell carcinoma of the breast and triple-negative invasive ductal carcinoma., Mutations in EGFR gene is associated with neoplasms., DNa mutational analysis in lebanese population shows that mutations of EGFR and KRAS are present in 8.5% and 37.7% respectivement in lung adenocarcinoma., The high concordance, specificity, and sensitivity demonstrate that EGFR mutation status can be accurately assessed using circulating-free tumor DNA., Mutation rate in domain of EGFR gene in investigated lung cancer population is in range with reported data in Caucasian race., In this study, we show that EGFR activation up-regulates FOXC1 expression via ERK- and PI3 K/Akt-mediated activation in basal-like breast cancer., EIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy., TIP30-induced downregulation of cyclin D1 transcription antagonizes EGFR signaling and suppresses tumorigenesis, Assessment of EGFR mutations in circulating tumor cell preparations from non-small-cell lung carcinoma patients is a very sensitive and specific diagnostic tool., Theanine derivatives effectively suppress the growth of lung cancer cells in vitro, ex vivo and in vivo by targeting EGFR/VEGFR-Akt/NF-kappaB pathways., The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility, Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition., Epidermal growth factor receptor exon 20 mutations in non-small-cell lung cancer and resistance to EGFR-tyrosine kinase inhibitors, the absence of both EGFR amplification and TERT promoter mutations is associated with longer survival in patients with glioblastomas, Study shows that EGFR mutation is detected in 47.7% of non-small-cell lung cancer and seems to be more frequent in patients 80 years and older., we determined that high EGFR expression may underlie the aggressive mechanism of advanced gastric cancer with high ND., EGFR mutation is associated with lung adenocarcinoma., EGFR mutations were not a prognostic factor in patients with surgically resected non-small cell lung cancer. (Meta-analysis), Deletion of Ctnnb1 significantly inhibits EGFR mutation dependent human lung tumor formation in mice., These results demonstrate coupling of CXCR7 with EGFR to regulate proliferation of breast cancer cells and suggest an important ligand-independent role of CXCR7 in breast cancer cells growth., phenotype was reproduced faithfully using four different BACs, indicating that EGFP can be used to target transcription factor function in transgenic mice., Data indicate that the efficacy of gefitinib in patients with non-small cell lung cancer (NSCLC) harboring an epidermal growth factor receptor (EGFR) mutation does not differ according to their body surface area (BSA)., Data indicate that epidermal growth factor receptor (EGFR) is expressed in liver macrophages in both human hepatocellular carcinoma (HCC) and in a mouse HCC model., T790M has a moderate effect on EGFR function but, when combined with other EGFR mutations it shows a remarkable enhancement of EGFR activity, RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR., The treatment of HaCaT cells with Pep2-YAC induced phosphorylation, internalization, and degradation of EGFR and organization of signaling complexes., Activation of TLR2 in airway remodeling results in induction of the expression of TGF-alpha, EREG, and AREG mRNA among the EGFR ligand family, and also activates EGFR signaling., SOX4 may modulate expression of EGFR, expression of both SOX4 and EGFR defines a subset of cholangiocarcinoma patients with poor prognosis., But minimal effects on EGFR phosphorylation., Both SH2 and GEF domains of GIV are required for the formation of a ligand-activated ternary complex between GIV, Galphai3, and EGFR., Targeting MUC1-C inhibits mutant EGFR signaling and survival., These findings support the hypothesis that increased levels of the VEGF and sVEGFR-1 and VEGF/SVEGFR-1 ratio may be associated with the pathogenesis of TA [threatened abortion ]., Elevated expression of the ER-alpha36-EGFR/HER2 loops is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen therapy., In addition, erlotinib therapy would be preferable in NSCLC patients with BM and EGFR mutation, especially those with exon 19 deletion., These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase., These results suggest that miR-27a may have antiviral activity against enterovirus 71 by inhibiting EGFR., Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have been shown to improve the prognosis of EGFR-mutated (exon 19/21) non-small cell lung carcinoma (NSCLC). Positive EGFR mutation status is associated with NSCLC in non-smokers., These studies demonstrate the utility of MSOT to obtain volumetric images of ligand probe biodistribution in vivo to detect orthotopic pancreatic tumor lesions through active targeting of the EGF receptor, This study suggests potential effects of SNPs of EGFR on the onset and susceptibility of biliary tract cancer., Studied structural changes induced upon binding by probing the solution conformations of full length exEGFR alone and bound to a cognate adnectin through HDX MS., The presence of 41 known treatment linked EGFR mutations in exons 18, 19, 20 and 21 of the EGFR gene was tested in 209 Irish patients., Del 19 and L858R are the most frequent mutations in Pakistani lung adenocarcinoma patients., Rare and compound EGFR mutations may occur and may have implications for treatment that differ from classically activating mutations., TGF-alpha level correlated with efficacy, and EGFR overexpression might predict cetuximab efficacy., These findings indicate that EGFR-mut tumors are likelier to be MPP-positive subtypes and that MPP may be a novel potential pathological marker of poor prognosis in Chinese LAC patients., There was a positive association between EGFR mutation and the presence of malignant pleural effusion in lung cancer., EGFR epigenetic activation has important implications in BRAFi resistance in melanoma, Re-examination of EGFR gene status should be considered to grasp a chance of erlotinib treatment after first line treatment. negative HGF staining could be a biomarker for longer PFS by erlotonib treatment., NTS/NTSR1 complex enhances breast tumor aggressiveness via EGFR/HER2/HER3 pathway., Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib., the signaling pathways initiated from the EGFR vary depending on the ligands bound in a cell specific manner, study concludes that while serum EGFR levels were elevated in breast cancer patients, EGFR level has no predictive and prognostic value in these patients, Combined inhibition of nucleolin and ras prevents EGFR activation in glioblastoma cells, additively reducing tumorigenicity., Glyco-engineering of anti-EGFR antibodies could optimize their function and minimize their side effects., Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling., In EGFR-mutant patients, frontline EGFR-TKI significantly reduced the sensitivity of subsequent chemotherapy compared with that of TKI-naive frontline chemotherapy., EGFR gene mutation status is significantly associated with serum carcinoembryonic antigen (CEA) status in advanced lung adenocarcinmoas;however, serum CEA is not an ideal predictor for EGFR mutation, These results suggest that the Glioma CpG Island Methylator Phenotype epigenetically regulates EGFR signaling, activation of EGFR signaling by its ligand on MCF-7 cells is sufficient to increase epithelial-mesenchymal transition phenotypes, to inhibit apoptotic events and to induce the loss of cytokeratin expression., EGF receptor signaling is regulated according to circadian rhythm, The cytoplasmic distribution of the EGFR staining appeared as a primary property of some squamous carcinoma cells, immunohistochemistry with the novel mutation-specific antibody could be used as a screening method to assess the EGFR L858R mutation status in primary lung adenocarcinoma., EGFR protein structure based on X-ray crystallography results., Collectively, these studies demonstrated that Mycoplasma pneumoniae induces airway mucus hypersecretion by modulating the STAT/EGFR-FOXA2 signaling pathways., Suggest potential applications for the noninvasive detection of E746_A750del mutations in plasma samples from non-small cell lung cancer patients., there is HER2 and EGFR, but not VEGFR expression in micropapillary urothelial carcinoma with invasive urothelial carcinoma, Suggest that the exocyst sec10, acting through EGFR, endocytosis, and the MAPK pathway is a candidate therapeutic target for acute kidney injury., MiR-491-5p-induced apoptosis in ovarian carcinoma by inhibition of both BCL-XL and EGFR leading to BIM activation., In our series of Caucasian women with advanced adenocarcinoma of the lung EGFR mutations seem to be associated with lower benefit from first-line platinum-based chemotherapy ., Our results indicated that the efficacies and outcomes of pemetrexed treatment in advanced lung adenocarcinoma patients with EGFR activating mutations were similar to those in patients with EGFR-wild-type genotype., REVIEW, Epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase involved in the signaling pathways that regulate cell proliferation, apoptosis, angiogenesis, and invasion., Our data indicated better efficacy of EGFR-TKI in Del-E746 than Del-L747. Deletional locations may affect EGFR-TKI efficacy., this study found a negative correlation between tumor thickness and membrane EGFR expression., The EGFRvIII mutation is not present in HNSCC, therefore, EGFRvIII does not influence treatment response in HNSCC and is not a usable clinical prognostic marker., EGFR interacted with GPRC5A and phosphorylated it in two conserved double-tyrosine motifs, Y317/Y320 and Y347/ Y350, at the C-terminal tail of GPRC5A., RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma., Our data indicate that EFIRM is effective, accurate, rapid, user-friendly, and cost effective for the detection of EGFR mutations in the saliva of patients with NSCLC., A functional link between MT4-MMP and the growth factor receptor EGFR., P-cadherin is able to potentiate ligand-dependent signaling of insulin-like growth factor 1 receptor in malignant keratinocytes and epidermal growth factor receptor in dysplastic cells., There were statistically significant correlations between the expression of PDGFR-alpha, c-Met, and EGFR and disease-free survival, Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer., Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of colorectal cancer ., Patients with EGFR-mutated non-small-cell lung cancer were more likely to develop brain metastases, but apparently also survived longer after brain metastases, Grandinin significantly reduce malignant cell viability and effectively induces apoptosis of malignant lung cells by mediating phosphorylation down-regulation of cellular signaling proteins EGFR and AKT., Overexpression of EGFR is associated with hepatocellular carcinoma., Data demonstrate that insulin treatment induces EGFR activation by stimulating the interaction of EGFR with insulin-like growth factor receptor 1 (IGF-1R), Either ligand-independent or ligand-induced EGFR phosphorylation was inhibited in lung cancer cells that strongly expressed DDX3X., Using multiple xenograft tumor models with varying EGFR expression, we determined the EGFR concentration in each model using a novel targeted agent (anti-EGFR affibody-IRDye800CW conjugate) along with a simultaneously delivered reference agent, Results suggest that GSK3b may function as a regulator of apoptosis and tumorigenesis in glioblastoma stem-like cell through EGFR and PP2A signalling, These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR hyperactivation in PDAC and that low CBL may define PDAC tumors likely to respond to erlotinib treatment., Epidermal growth factor receptor overexpression, but not high EGFR copy number, is a poor prognostic factor in HER2-positive primary breast cancer., KIAA1199 is an oncogenic protein induced by HPV infection and constitutive NF-kappaB activity that transmits pro-survival and invasive signals through EGFR signalling., This expert group recommends testing for KRAS and NRAS status in all patients with metastatic CRC being considered for anti-epidermal growth factor receptor (anti-EGFR) therapy, This model demonstrates the role of ErbB receptors underlying prolactinoma tumorigenesis and the feasibility of targeting these receptors for translation to treatment of refractory prolactinomas., These results suggest that the PKC pathway and PDGFR/EGFR transactivation pathway play important roles in HCA2-mediated Akt activation., Our platform, which combines experimental data from structure-function and bioinformatics analyses based on MAPK substrate similarities, provides a low-cost and rapid approach for the identification of novel aDUSP-interacting proteins., Cell blocks were underutilized for EGFR testing., EGFR mutation is associated with non-small-cell lung cancer., The rationale for simultaneous targeting of EGFR and PDGFR., T-cadherin regulates prostate cancer cell behavior by tuning the balance in EGFR/IGF-1R activity and enhancing the impact of IGF-1R, Results shed some light on the mechanisms promoted by EGFRvIII that contribute to the malignant microenvironment in glioblastoma and identified that C/EBPb increased IL-6-driven angiogenesis and thereby glioblastoma progression., The BIM polymorphism is not associated with EGFR mutant lung cancer., it is essential to confirm any EGFR L858R-positive cases by molecular methods or at least discard the presence of HER2 overexpression/amplification before rendering a diagnosis, EGFR was found highly expressed in cancer tissues, and its knockdown inhibits growth and invasion of gastric cancer cells., the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with bone mineral density in white women, as conducted., Suggest that curcumin reduced oral squamous carcinoma cell proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3., Demonstrate that Mig-6 could reverse gefitinib resistance through inhibition of EGFR/ERK pathway in non-small cell lung cancer cell lines., preclinical evaluation of genistein-derived EGFR inhibitors suggests that these compounds are much more potent sensitizers of cells to radiation than the parent isoflavonoid, genistein, Date indicate there were no significant differences between the lung cancer patients with epidermal growth factor receptor (EGFR) exon 19 and 21 mutations for overall survival., We conclude that the decreased expression of the tumor-suppressive miR-23b/27b cluster enhanced cancer cell proliferation, migration and invasion in BC through direct regulation of EGFR and c-Met signaling pathways, We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR-containing endosomes., CUL4A regulated EGFR transcriptional expression., In endometrial adenocarcinomas a relatively weak positive correlation between EGFR expression and melatonin blood serum levels is observed. With that, there is a negative correlation between the blood levels of EGF and melatonin., Phosphorylated ErbB1-4 and heregulin contribute to poorer patient prognosis in CRC. This heregulin-ErbB family member autocrine loop may be a candidate for targeted treatment of CRC., EGFR expression correlates negatively with BRCA1, whereas miR-146a levels increase with BRCA1., PHD3 controls EGFR activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 and promotes the internalization of EGFR., PHD3 loss sustains cell proliferation through the control of EGFR., The activation is fully dependent on the transactivation of the epidermal growth factor receptor (EGFR)., No difference in gender and age regarding EGFR mutation status was observed on cytological as well as on histological material in patients with non-small cell lung cancer, MCM7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor, direct smears but also liquid-based cytology slides represent an effective preparation and storage medium for cytological material to be used for EGFR molecular testing., Preanalytical workflow optimisation may reduce errors in down-stream sequencing in EGFR mutation detection., These findings should assist clinicians in assessing the likelihood of EML4-ALK rearrangements and EGFR mutations and understanding their biological implications in NSCLC., Our study is the first to show radiosensitive biology of EGFR-mutated tumors in definitive CRT with curative intent and this finding could serve as a credible baseline estimate of EGFR-mutated population in stage III nonsquamous NSCLC., Rab11-dependent EGFR recycling has a role in synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M, Among those with EGFR-sensitive mutation, the cumulative risk of brain metastasis was lower in the icotinib group., the clinical profile of EGFR-mutant lung cancer carrying a pretreatment nongermline T790M mutation was similar to that of sensitive EGFR-mutant lung cancer, except for an overrepresentation of never-smokers and brain metastasis, Extracellular EGFR-activating mutations in glioblastoma enhance ligand-binding affinity without directly promoting EGFR dimerization., EGFR-mutated patients tended to be female and non-smoker and experienced a prolonged OS suggesting a possible positive prognostic effect. c-MET mutations did not affect survival. Target therapy might be considered in EGFR and c-MET-mutated patients., The presence of EGFR activating mutations should be included as an index in the prognostic models for lung adenocarcinoma patients with brain metastasis., Expression profiling demonstrated that AREG-activated EGFR regulates gene expression differently than EGF-activated EGFR, EGFR-activating mutations are associated with response to therapy in non-small-cell lung cancer., analysis of activator-receiver preferences among ErbB proteins, Cumulatively, the data reported here connect the function of EGFR to Chlamydia trachomatis attachment and development in the host cells., we demonstrate that SEPT9 negatively regulates EGFR degradation by preventing the association of the ubiquitin ligase Cbl with CIN85, resulting in reduced EGFR ubiquitylation, ligand-dependent constitutive activation of EGFR causes reduced ROS generation and increased antioxidant expression, mtEGFR can be activated by pmEGFR through de novo synthesized palmitate to promote mitochondrial fusion and survival of cancer cells., Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signaling networks., Ubiquitinated EGFR interacts with Alix in mammalian cells and is involved in the regulation of multivesicular body sorting., Data show that epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) rs12538371, rs845561, and rs6970262 were associated with head and neck squamous cell carcinoma (HNSCC) risk among never tobacco users., approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1., study indicates that polymorphisms in the EGFR gene are associated with glioma susceptibility in the Chinese population., Changes in plasma EGFR mutation status can be successfully assessed using the peptide nucleic acid-zip nucleic acid polymerase chain reaction clamp method and can serve as an independent outcome predictor., First- or second-line afatinib demonstrated preliminary activity and manageable safety in EGFR FISH-positive patients with advanced non-small-cell lung cancer., EGFRvIII-mediated radioresistance, but not chemoresistance, was also modulated by JAGGED1, Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor, Tumor-suppressive miR206 inhibited dual signaling networks activated by MET and EGFR in lung squamous cell carcinoma., p120ctn down-regulation and EGFR overexpression are able to mimic human ESCC in a culture model, This finding suggests that the EGFR T790M mutation-derived antigen could be a new target for cancer immunotherapy., All specimens appeared to be suitable for EGFR gene mutation analysis, irrespective nature or origin, Data suggest that the mechanism of gamma-H2AX on the angiogenic activity of hepatocellular carcinoma (HCC) might go through EGFR/HIF-1alpha/VEGF pathways under hypoxic conditions., High EGFR expression is associated with oral cavity neoplasms., Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1., The presence of well-differentiated components in lung adenocarcinoma, such as lepidic, papillary and acinar, indicates a higher EGFR mutation rate, while the solid and mucinous component indicate a lower EGFR mutation rate., Data indicate that lipid domains regulate transition rates between diffusion states of liganded epidermal growth factor receptor (EGFR)., An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression in larynx carcinoma., In patients with EGFR mutations, women have better PFS to EGFR-TKIs than men, and rare EGFR mutations are more frequent in high grade adenocarcinomas than in low grade tumors., Negative modulation of EGFR signaling by the chimeric ubiquitin ligases can inhibit malignancy of SPC-A1 cells and sensitize these cells to chemotherapy., Adenocarcinomas with ALK rearrangement appeared as solid masses with lobulated margins at CT, were more likely to be associated with lymphangitic metastasis, advanced ln metastasis, and pleural/ pericardial metastasis than were tumors with EGFR mutations., EGFR mutations are closely associated with a high response rate to lung cancer treatment with an EGFR tyrosine kinase inhibitor., EGFR L858R mutation is associated with lung adenocarcinoma patients with dominant ground-glass opacity, ErbB2 and ErbB3 homodimers are endocytosis deficient owing to the lack of endocytic codes. Interestingly, EGFR-ErbB2 or EGFR-ErbB3 heterodimers are also endocytosis deficient, EGFR mutations are associated with response to chemotherapy in lung adenocarcinoma., Data suggest expression of p110 splice variant of EGFR (potential EGFR antagonist) is up-regulated on surface of chorionic villi of pre-eclampsia as compared to that of normal term birth; EGF blocks cell death/apoptosis of cytotrophoblast cell line., The synergism between HER2 and EGFR in determining radiosensitivity., Erlotinib/capecitabine chemotherapy was significantly better in older Chinese patients with advanced Adenocarcinoma of the Lung with EGFR mutations., Results show gene amplification of IGF1R and EGFR exclusively in malignant cases of phyllodes tumors suggesting a potential use as therapeutic targets., Study shows that inactive EGFR, LAPTM4B, and the Sec5 subcomplex are required for basal and starvation-induced autophagy. LAPTM4B and Sec5 promote EGFR association with the autophagy inhibitor Rubicon, which in turn disassociates Beclin 1 from Rubicon to initiate autophagy., GAB adaptor proteins play a role in ERBB3-independent activation of the PI3K pathway by mutant EGFR in EGFR-mutant human cell lines., Suggest that TXNIP plays a critical role in anti-Her-1/Her-2 treatment and may be a potential prognostic marker in breast cancer., EGFR mutation status was associated with lepidic dominant histologic subtype of lung adenocarcinomas., CREB silencing using RNA interference reduced basal levels of BCRP mRNA and diminished the induction of BCRP by EGF. Chromatin immunoprecipitation assays confirmed that a putative CRE site on the BCRP promoter bound p-CREB by a point mutation, IGF-1R expression was a negative predictive factor for a response to EGFR-TKIs in NSCLC patients harboring activating EGFR mutations., BRAF overexpression could be an independent factor causing tumorigenesis in gliomas regardless of phospho-EGFR expression., We present a comprehensive analysis of mutational changes affecting key members of the EGFR signaling pathway emerging in tumor biopsies of patients treated with cetuximab and in cell models, EGFR mutations are associated with response to chemotherapy in colorectal cancer., Our findings support the genetic heterogeneity of non-small cell lung cancer in Latin America, confirming that the frequency of EGFR mutations is intermediate between that observed in the Asian and Caucasian populations., EGFR gene mutation is associated with non small cell lung carcinoma., EGFR is overexpressed in Bruneian lung cancer patient., Results show that suppression of EGFR membrane recycling by SNX1 appears to be critical for the activation of EGFR /PI3K/AKT signaling pathway in human lung cancer cells., Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors., Interaction of Cav1 with its receptor EGFR inhibits signaling and reduces cell proliferation, supporting a tumor suppressor function for Cav1., EGFR activation by EGF stimulation, exon-19 deletions, and L858R mutation could induce PD-L1 expression in nsclc., These findings suggest that genomic deletion as well as additional regulatory mechanisms may contribute to EGFRvIII expression in HNSCC., MET transactivation in U87MG human glioma cells in vitro is proportional to EGFRvIII activity and involves MET heterodimerization associated with a focal adhesion kinase (FAK) scaffold., Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt and ERK1/2 phosphorylation via A1R-mediated transactivation of EGFR., Letter/Case Report, The majority of rare EGFR mutations was associated with smoking, shorter overall survival, and decreased tyrosine kinase inhibitor response when compared with classic EGFR mutations., EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression., Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations., nicotine contributes to the progression and erlotinib-resistance of the NSCLC xenograft model via the cooperation between nAChR and EGFR., Inhibiting IL6 signaling in ovarian cancer cells and ovarian cancer xenografts upregulated EGFR signaling and ERK activation., Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR signaling pathway., In surgically resected primary USP8-mutated tumor cells, USP8 knockdown or blocking EGFR effectively attenuates ACTH secretion. Inhibition of USP8 or EGFR is promising for treating USP8-mutated corticotrophin adenoma., results indicate that 31 pleural mesothelioma patients show a wild-type EGFR gene when analyzing the codons D19, 768, 790, 858+861, 731+734, 785, 797+801, 831, and 868, whereas 2 patients have a mutation in the EGFR gene in codon 719, Coexpression of EGFR and CXCR4 predicts poor prognosis in resected pancreatic ductal adenocarcinoma, These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells., hypermethylation of the CpG dinucleotide in EGFR codon 790 leads to the C-->T transition mutation, causing resistance to EGFR-TKI inhibiting drugs., Brain metastases are frequent in advanced EGFR-mutated or ALK-rearranged non-small-cell lung cancers., PCI of rGel/EGF was shown to be highly effective against EGFR-expressing cell lines., EGFR mutations are associated with non-small cell lung cancer., Immunohistochemical NK-1R and pEGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia., High EGFR expression is associated with pancreatic cancer., High EGFR expression is associated with glioma cell invasion., The relative stability of EGFR amplification indicates that molecular data obtained in the primary tumor can be used to predict the EGFR status of the recurrent tumor., AR, EGFR, and BRCA1 might be unique biomarkers for targeted therapy and prognosis in TNBC., EGFR gene mutations are associated with response to chemotherapy in non-small cell lung cancer., in pulmonary nodules anti-EGFR antibody reduced the positivity to estrogen and progesterone receptors which enhance survival of LAM cells and Snail expression, The lack of response to EGFR inhibitors in EGFR mutated lung cancer may indicate that tumor differentiation affects tumor dependency on EGFR as a driver oncogene., This study investigates the role of non-canonical EGFR pathway in resistance mechanism against cisplatin. Wild type and mutated (exon 19 deletion) EGFR-expressing cells responded similarly to cisplatin by showing MAPK-mediated EGFR phosphorylation., this is the first study focused on the effect of statins in selected patients with advanced-stage NSCLC harbouring KRAS mutation treated with EGFR-TKIs. A randomized prospective clinical trial should be conducted to confirm our results in the future., Breast cancer patients with co-heightened EGFR/AKT1 gene copy numbers had a worse outcome than those with only high EGFR gene copy numbers., Helicobacter pylori induces internalization of EGFR via novel TAK1-p38-serine activation pathway which is independent of HB-EGF., this study verified that both Notch-1 and EGFR involved in glioblastoma multiforme (GBM) tumorigenesis and may provide important information for GBM clinical treatment and prognosis, Chronic nicotine exposure because of cigarette smoking mediates resistance to EGFR-TKI via an EGFR signal., mutations associated with pneumonic-type lung cancer relative to other lung cancer, miR-129, EGFR, and MMP9 appear to be promising therapeutic targets for preventing the metastasis of non-small cell lung cancer, Bladder cancer cell lines shed soluble EGFR ectodomain., Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-kappaB signalling pathway in human epidermoid carcinoma A431 cells, Suppression of EGFR ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes., CA-SSR1 Polymorphism in Intron 1 of the EGFR Gene in Patients with Malignant Tumors Who Develop Acneiform Rash Associated with the Use of Cetuximab, Two patients had simultaneous T790M EGFR or PIK3CA mutation alongside EGFR activating mutation., Study demonstrates that down-regulation of GALNT1 is sufficient to suppress malignant phenotype of HCC cells by decreasing EGFR signaling., Report inhibition of non-small cell lung cancer growth by a novel small molecular inhibitor of EGFR., Results show that inhibition of the Shp2 PTP activity impairs mutant EGFR signaling and suppresses EGFRL858R-driven lung adenocarcinoma., CEA response after 1 month of EGFR-TKI therapy could be a useful marker, worthy to further studies, as early predictor of treatment outcome in EGFR wild-type/unknown unselected NSCLC cases for which no molecular predictor is yet available, MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma., Experimental data showed upregulation of the selected EGFR cascade( Akt, nuclear factor kappa B p50 ) stromal expression of EGFR, and nuclear localization of COX-2 in metaplastic gland cells of laryngeal cancer tissue sample, UNC50 may plays some roles in HCC progression by affecting the EGFR pathway, Our data provide evidence that YAP1 upregulation of EGFR plays an important role in conferring therapy resistance in esophageal cancer cells. Targeting YAP1-EGFR axis may be more efficacious than targeting EGFR alone in esophageal cancer., EGFR/ERBB4 expression in trophoblasts correlates with cell cycle progression and hyperplasia in complete hydatidiform moles, Results show how GPRC5A deficiency leads to dysregulated EGFR and STAT3 signaling and lung tumorigenesis., These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions., PGE2 enhances glioma cell survival and proliferation though its ability to trans-activate Epithelial Growth Factor receptor and beta-catenin, Seventeen different types of pathogenic EGFR-TK domain mutations were detected in 55 of the 210 samples (26%)., There are distinct functional differences between different EGFR mutations. The functional differences between different mutations argue for the development of mutation specific targeted therapies., EGFR signaling defines Mcl1 survival dependency in neuroblastoma., IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions. This may be relevant to other virus entry processes employing EGFR., RB is lost in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer., These results suggested that the mechanism underlying CD9-induced suppression of cell proliferation may involve the inhibition of phosphorylation of EGFR and the activity of PI3K/Akt and MAPK/Erk signaling pathways, EGFR mutation was associated with lung cancer in never-smoker Asian females., HDAC9 promotes tumor formation of glioblastoma via TAZ-mediated EGFR pathway activation., the present study indicated that the mechanism of action of miR-146b-5p in GBC involves the regulation of EGFR expression., These results suggested that ECHS1 may promote cell proliferation in hepatocellular carcinoma in an EGFR-dependent manner., EGFR copy number gain is related to crucial clinicopathological features and early recurrence, indicating that EGFR copy number gain might be a poor prognosis factor for Taiwanese HCC., estimated prevalence of sensitizing EGFR mutations (exon 19 del, exon 21 L858R) in an unselected samples of newly diagnosed advanced non-small cell lung cancer patients in Spain, In this study, we demonstrate that 5a-induced cell cycle arrest and apoptosis by inhibiting EGFR and HER2 activity and downstream activation of PI3K/Akt and MEK/Erk pathways., The epidermal growth factor receptor (EGFR) is a common driver molecule in non-small cell lung cancer (NSCLC), making it an attractive target for the development of novel therapies in the current era of personalized medicine., Some of the most interesting studies involved third-generation epidermal growth factor receptor (EGFR) inhibitors in patients with EGFR mutations and resistance to agents such as erlotinib and gefitinib., Circulating DNA is easy to obtain, convenient biological material, although quantitative analysis cannot be used as diagnostic tool, but it can be applied to determination of EGFR mutations, basis of the tyrosine kinase inhibitors application., we suggest that Musashi-1, Lgr5, and pEGFR are overexpressed in human SIAs and may play roles in human SIA carcinogenesis and progression., The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of Lung adenocarcinoma in residents of southern Russia., Gefitinib is an effective and well-tolerated therapeutic option for patients with locally advanced and metastatic NSCLC harboring EGFR mutations., Cytological specimens are optimal for EGFR mutation analysis in advanced NSCLC., In multivariable analyses, in both patients with EGFR-mutant and KRAS-mutant lung adenocarcinomas, advanced stage at the time of diagnosis was found to be independently associated with shorter survival., CHCHD2 and EGFR protein expression levels were positively correlated and upregulated relative to normal lung in non-small cell lung carcinoma tumor-derived xenografts., EGFR protein overexpression was observed in one fourth of triple negative breast cancer cases with very low incidence of EGFR-activating mutations in patients of Western India., EGFR promoter methylation was common, and it might be associated with HPV 16 infection in Chinese cervical squamous cell carcinoma., This is the first structure-based docking study for the selected protein targets and anticancer drug, and S100A8 and EGFR are attractive anticancer targets and midostaurin with effective drug properties for therapeutic intervention in kidney cancer, Results demonstrated that Kindlin-2 participates in EGFR signaling and regulates breast cancer progression., Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm., EGFR-activating mutation is associated with the treatment outcome of first-line chemotherapy in advanced non-small cell lung cancer patients., Molecular dynamic simulations show that the formation of the asymmetric dimer changes the dynamics of EGFR kinase domain by suppressing fluctuation of the protein and altering the direction of motion of the protein., N-glycosylation is a critical determinant of EGFR conformation, KRAS and EGFR co-mutation was detected in one case. PPMA patients with ALK rearrangements or KRAS mutation represent a unique subtype in Non-Small-Cell Lung Carcinoma, HER2 and EGFR)on the breast cancer xenografts in a mouse orthotopic model were successfully detected in a multiplexed way, illustrating the potential of FRES as a molecular diagnostic instrument, EGFR, ErbB2 and MET genes are frequently amplified in gastric carcinoma., Combined L-EGFR + H-Beclin1 expression may represent a biomarker in identifying relatively favorable clinical presentations and prognosis, thus envisaging possible EGFR/Beclin1-targeted therapies., ANO1 and EGFR form a functional complex that jointly regulates head & neck squamous cell carcinoma cell proliferation., PCNA phosphorylation by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis, Combinations of exonic deletions of exon 25 to 28 lead to the oncogenic activation of EGF receptor in the absence of ligand and consequent cellular transformation, indicating a significant role of C-terminal domain in modulating EGFR activation., EPAS1 is a key factor in the EGFR-MET crosstalk., results suggest that suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, inducing an aggressive phenotype in tumor cells that are EGFRvIII-negative, These findings unveil NF-kappaB activation as a critical adaptive survival mechanism engaged by EGFR oncogene inhibition and provide rationale for EGFR and NF-kappaB co-inhibition to eliminate residual disease and enhance patient responses., Patients with any EGFR, CK19, CK20 or survinin positivity in their peripheral blood obtain less benefit from radiotherapy., Report bio-ferrography immunomagnetic isolation procedure for the separation of EGFR high positive circulating tumor cells., These data suggest that GEF-induced autophagy functions as cytoprotective and indicates the potential therapeutic possibility of using CAM for GEF therapy., Our experimental findings suggest that afatinib is especially effective against NSCLC carrying an EGFR exon 19 deletion., P53, EGFR and MGMT proteins play important roles in the occurrence and development of brain glioma., The -216TT and -191AA genotypes and GA haplotype of the EGFR gene were found to be associated with an increased risk of gastric cancer in a Mexican population., Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of Epidermal growth factor receptor, to gain insight into the molecular circuitries of EGFR induced hepatocarcinogenesis diverse computational approaches were employed. This revealed master regulatory proteins and permitted network constructions of 82 disease regulated proteins, The P2 motif was required for the NS5A-mediated disruption to EGFR trafficking., significant inhibition of the EGFR pathway (using EGFR as the readout) was observed in patients treated with panitumumab, but this was not observed in patients treated with erlotinib, The ultra-sensitive ddPCR assay revealed that pretreatment T790M was found in the majority of NSCLC patients with EGFR-activating mutations., High EGFR expression is associated with triple-negative breast cancer., Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma., MET gene may be useful in predicting shortened PFS and OS after Gefitinib treatment in lung adenocarcinoma. The correlation between MET gene status and clinical outcomes for EGFR-TKI should be further evaluated using large scale samples., Results showed that EGFR mutation was detected in 17.2% of Chinese patients with pure squamous-cell lung cancer, especially in females indicating the importance of this mutation in tailoring a personalized therapy with tyrosine kinase inhibitors., In comparing Han and Uighur groups in China, exon 19 deletion was more common than L858R in exon 21 in Uighur patients. In Han patients, EGFR-sensitive mutations occurred in female, never-smoking patients with well-differentiated tumors; but for Uighur patients only smoking history showed an obvious correlation., Data (including data from SZ95 sebocyte cell line) suggest sebocytes abundantly express EGFR with lower levels of erb-b2 receptor tyrosine kinases ERBB2 and ERBB3; expression of these receptors appears coordinated with lipogenesis in specific ways., Identification of a novel tumor-promoting function for IGFBP2 of activating EGFR/STAT3 signaling and facilitating EGFR accumulation in the nucleus, thereby deregulating EGFR signaling by two distinct mechanisms., This polyphenol is able to inhibit directly but partially the enzymatic activity of the EGFR intracellular domain. The present work shows that curcumin also influences the cell membrane environment of EGFR, Of 11 gefitinib responders, 6 patients were identified as having tumor with activating EGFR mutation., Data show that MM-151, an oligoclonal antibody, targeted against nonoverlapping epitopes on epidermal growth factor receptor (EGFR)., Report EGFR expression/KRAS mutations and the effect of EGFR expression on stage, prognosis and response to conventional chemotherapy agents., CD82 down-regulation could be a critical step involved in the EGFR over-expression and the stronger tumorigenic activity triggered by EGFR mutations, Results suggest that the EGFR and NRas signaling axis are a central component of fibroinflammatory signaling., Authors develop methods to detect five common EGFR somatic mutations in tumor tissues from NSCLC patients., It represents a potential therapeutic option against LM after failure of standard-dose EGFR-TKIs., carbon monoxide-releasing molecule-2 mediated p38 MAPK and JNK1/2 activation via a c-Src/EGFR/PI3K/Akt pathway, EGFR mutation is associated with response to treatment in nonsmall-cell lung cancer., Besides the already reported indirect EGFR activation through GM3, sialidase NEU3 could also play a role on EGFR activation through its desialylation., AZD9291 was highly active in patients with lung cancer with the EGFR T790M mutation who had had disease progression during prior therapy with EGFR tyrosine kinase inhibitors., Rociletinib was active in patients with EGFR-mutated NSCLC associated with the T790M resistance mutation., Good safety in chemo-naive PS 2 patients with EGFR wild-type or unknown non-squamous NSCLC., Study confirmed that EGFR 3'UTR 774 T>C polymorphism interfered with miRNA/mRNA interaction, and showed that the minor allele was associated with an elevated risk for development of pulmonary hypertension in chronic obstructive pulmonary disease., Cetuximab increases a P-gp substrate intracellular accumulation in both P-gp expressing cell lines, independently of their EGFR expression., Findings implicate a prominent role for activating EGFR mutations in the pathogenesis of ISP and associated SNSCC., Results indicate that AMG 595 is a promising candidate to evaluate in epidermal growth factor receptor variant III (EGFRvIII)-expressing glioblastoma multiforme (GBM) patients., Report documents that half of T790M-positive EGFR-mutant lung cancers treated with rociletinib are T790-wild-type upon progression, suggesting that T790-wild-type clones can emerge as the dominant source of resistance., Exogenously expressed HER2 failed to associate with EGFR or HER3 in MDA-MB-231 cells, while overexpression of HER2 enhanced HER family dimerization in MCF-10A and MCF-7 cells, EGFR gene promoter methylation is associated with secondary resistance to gefitinib., EGFR and KRAS mutation were associated with non-small cell lung carcinoma., Our findings provide insight into the diversity of mechanisms through which tumors acquire resistance to AZD9291 and highlight the need for therapies that are able to overcome resistance mediated by the EGFR C797S mutation., Data show that dacomitinib efficiently impairs epidermal growth factor receptor (EGFR) signaling in vivo and has an effect on murine model tumor growth and survival in EGFR-amplified glioblastomas (GBM) cells., Data indicate a potent and specific ADAM metallopeptidase domain 17 (ADAM17) inhibitory antibody, MEDI3622, which induces tumor regression or stasis in many epidermal growth factor receptor (EGFR)-dependent tumor models., Proteins induced by PIK3CA mutations correlated with EGFR signaling and reduced relapse-free survival in basal-like breast cancer., EGFR IHC overexpression evaluated by scoring system 1 might be suitable to be used in predicting patients survival in ESCC. EGFR gene amplification showed delayed prognostic information after 20 months., Results indicate that EGFR expression is enhanced in pancreatic cancer cells through CD9 downregulation promoting cell proliferation and migration., increased methylation level at EGFR promoter was found in tumour tissues than the corresponding adjacent noncancerous., our data demonstrated that blockade of the EGFR might efficiently increase the antitumor activity of selumetinib in a subgroup of TNBC and that this phenomenon might be related to the effects of such combination on both ERK1/2 and AKT activation., We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II., The frequency of EGFR mutations is 63% in the southern Taiwanese lung adenocarcinoma patients., ACh-induced activation of EGFR/PI3K/AKT pathway and subsequent IL-8 upregulation may be one of the important mechanisms of M3R function., DNA mutational analysis of EGFR mutation is a reliable test for diagnosing lung adenocarcinoma., Mutation of C797S in EGFR is a novel mechanism of acquired resistance to third-generation TKIs. The context in which the C797S develops with respect to the other EGFR alleles affects the efficacy of subsequent treatments., Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes., p53 and EGFR expression was positively correlated in triple-negative breast cancer (TNBC), which enables us to explore the molecular biological characteristics of TNBC, so as to provide new ideas for the treatment of TNBC., EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR., Mutant EGFR enhances the oncogenic properties of MCF10A cell line, and increases sensitivity to gefitinib., The L858R/T790M EGFR mutant, when treated with sialidase or sialyltransferase inhibitor, showed an increase in tyrosine phosphorylation., High EGFR expression is associated with poor Response to Sunitinib in Breast Cancer., In non-apoptotic cells, nuclear EGFR induced SOS1 expression by directly binding to the SOS1 promoter., EGFR tyrosine kinase inhibitors enhance the sensitivity of NSCLC cells to vATPase inhibitors by decreasing Hif-1alpha/Bnip3 expression., mutational status is a prognostic factor for survival after recurrence in patients with resected lung adenocarcinoma, EGFR mutations are associated with response to therapy in non-small cell lung cancer patients., Nuclear EGFR occurs in ameloblastomas in association with Cyclin D1 expression, EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via activation of signal transducer and activator of transcription 3 (STAT3), thereby promoting self-renewal and tumor progression of glioma stem cells., the EGFR and ErbB-3 heterodimerization, regarded as the origin of intracellular signaling pathways, was investigated., the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment, The expression of CD146 and HIF1a was positively correlated with EGFR and CD31, respectively in salivary gland adenoid cystic carcinoma., Upregulation of EGFR and c-Met is associated with epithelial mesenchymal transition in response to increased matrix rigidity in pulmonary adenocarcinoma., Here we demonstrated a new AFM technique-topography and recognition (TREC) imaging-to simultaneously obtain highly sensitive and specific molecular recognition images and high-resolution topographic images of EGFR on single breast cancer cells., Conclude that not only ERalpha, but also basal activities of EGFR and Src kinase are essential for Cd-induced signal transduction and activation of MAPK/ERK pathway for breast cancer cell proliferation., We review methods currently available and show the latest results from a new single-molecule localization-based method, fluorophore localization imaging with photobleaching (FLImP), using the epidermal growth factor (EGF) receptor (EGFR), Highly sensitive dPCR thus detected T790M in all NSCLC patients harboring activating EGFR mutations whether or not they had received EGFR-TKI treatment., SHB-EGF acts similarly to other EGFR ligands and is capable to induce EGFR nuclear translocation., The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer., Validate a locked nucleic acid based wild-type blocking PCR for the detection of EGFR exon 18/19 mutations in non-small cell lung carcinoma., investigated the involvement of the RAS/MEK/ERK and PI3K/AKT/mammalian target of rapamycin (mTOR) pathways on metabolic alteration in lung adenocarcinoma cell lines with activating EGFR mutations, KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy, The increased expression of EGFR in LAM cells is not associated with EGFR gene amplification, although it may be a marker of disease progression; the role of this receptor in LAM pathogenesis should be further investigated., Nickel accumulation in lung tissues is associated with EGFR mutations, miR-21 expression, and a poor outcome in lung cancer never-smoking patients., RAB5C is identified as a new TBC1D16 target and showed that it regulates EGFR in melanoma cells., Dual blockade of EGFR and HER3 may enhance the targeted disruption of HER family signaling in these cancers both by blocking parallel and overlapping signaling pathways and potentially blocking the emergence of resistance., Exon 19 deletion in EGFR gene is associated with response to therapy in non-small cell lung cancer patients., In pretreated elderly patients with advanced or recurrent EGFR-wild type non-small cell lung cancer, daily oral erlotinib was well tolerated., Gemcitabine plus erlotinib is more effective than gemcitabine alone for treating metastatic pancreatic cancer patients, especially those with EGFR mutations., In transgenic mice programmed to express both mutant oncogenes in the lung epithelium, the resulting tumors express either the KRAS, or the EGFR oncogene., EGFR-mutant allele-specific imbalance is a significant event in non-small cell lung cancer, specifically associated with EGFR exon 19 deletions, among lung adenocarcinoma patients with EGFR mutations, those mutated at exon 19 had the highest incidence of brain metastasis(BM); patients with EGFR mutations are more likely to develop heterochronous BM, Afatinib administration in non small cell lung cancer patients with EGFR mutation were successful., The therapeutic activity of TUSC2 could extend the use of erlotinib to lung cancer patients with wildtype EGFR., Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase c-Cbl., EGFR and KRAS mutation status are both predictive factors for the treatment efficacy., Through selective knockout or inhibition of the network components, we show that the interaction between epidermal growth factor receptor (EGFR) and S100A4 modulates the sensitivity of angiogenesis development to matrix metalloproteinases (MMPs) activity, study describes a novel EGFR exon 12 mutation acquired in gastrointestinal tumors of 1 out of 3 patients treated with panitumumab; the EGFR G465R mutation introduces a positive charge within the overlap of the panitumumab and cetuximab epitopes; it abrogates antibody binding and mediates cross-resistance to both antibodies in EGFR G465R-transfected Ba/F3 cells, EGFR and p53 are the major targets in TNBC also for our population., our data suggest that the anti-inflammatory actions of paricalcitol in tubular cells could depend on the inhibition of TGF-a/ADAM17/EGFR pathway in response to aldosterone, showing an important mechanism of VDRAs action., UVC/cisplatin-triggered EGFR activation depends on EGFR internalization and intracellular retention. EGFR signalling from this MVB subpopulation delays apoptosis and might contribute to chemoresistance, The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2 Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner, EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1., Although positive predictors of response to anti-EGFR antibodies remain unknown, multiple determinants of resistance have been described, including alterations interfering with antibody-receptor interaction, deregulation of parallel signaling pathways, These results showed that deguelin possessed antitumor effect by targeting Akt in dual axis such as EGFR and IGF1R signaling pathways and suggested that it provides an applicable therapeutic strategy for HNSCC patients., these data suggest that reduced miR-133 levels in GC tissues promote Gastric carcinoma growth, which possibly contributes to a low survival rate of GC patients. MiR-133 may target Her-2 to suppress GC cell growth, the findings suggest that the observed EGF response underlies an EGFR integrin cross-talk under recruitment of receptor proximal FAK and Src, and MAP kinase and p190RhoGAP as receptor distal events., Since EGFR and ER both are substrates for PTPH1 in vitro and in intact cells, these results indicate that an inhibitory EGFR-ER protein complex can be switched off through a competitive enzyme-substrate binding., Study shows the phosphorylation of EGFR and HER2 after MEK inhibition in a MEK1-mutated gastric cancer cell line suggesting that EGFR and HER2 activation may serve as a potential mechanism responsible for the resistance to a MEK inhibitor., Certain EGFR glycosylation signatures appear to be unique to colorectal cancer., Exon 19 deletion in EGFR is an independent prognostic factor in Brain metastasis from non-small-cell lung cancer . It should be integrated into the prognostic scoring classification system for NSCLC., Epidermal growth factor receptor (EGFR) is frequently overrepresented in TNBC., Afatinib significantly improved PFS versus cisplatin/pemetrexed in Japanese EGFR mutation-positive lung adenocarcinoma patients., The majority of patients with advanced lung adenocarcinomas harboring EGFR exon20ins do not respond to EGFR tyrosine kinase inhibitors therapy, The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree., The R776H mutation activates EGFR in a dimerization-dependent manner by preferentially adopting the acceptor position in the asymmetric dimer., soluble EGFR is a potential candidate for metastasis-associated biomarkers of Hepatocellular carcinoma., the human EGFR is subjected to O-GlcNAcylation in the A431 and A549 tumor cell lines., The anti-tumor effects of quercetin 3-O-glucoside were mediated by selectively inhibiting the EGFR-mediated FAK, AKT, MEK1/2, and ERK1/2 signaling pathway, Our results indicate that the transactivation of HER2 and EGFR by the pro-inflammatory cytokine/neuropeptide SP in BC cells is a c-Src and MMP-dependent process., Data show that significantly better overall survival was observed in patients with coexistence of high epidermal growth factor receptor (EGFR) expression and low p-Akt proto-oncogene protein expression., Out of the patients with EGFR mutation and advanced disease, only 38% received EGFR-tyrosine kinase inhibitor (TKI) in first-line therapy., Patients with a high EGFR expression seemed to present worse cliniconeurological status., E-cadherin may play a significant role in the sensitivity regulation of EGFR molecular targeting treatment. E-cadherin may provide important clues for selecting proper EGFR-TKI molecular targeting treatment., These results showed that miR-133a suppresses cervical cancer growth in vitro and in vivo through targeting EGFR, suggesting that miR-133a can be a potential target for the treatment of cervical cancer, these data suggest that reduced miR-133 levels in GBM tissues promotes cell growth and decreases cell apoptosis, possibly through targeting mRNA of EGFR to suppress its translation., EGFR amplification occurs frequently in lung ADC patients harboring EGFR activating mutations, and could serve as an indicator for better response from EGFR-TKI treatment., Data suggest that AMP-activated protein kinase (AMPK) regulates HER-2 proto-oncogene protein and epidermal growth factor receptor (EGFR) in HER2-amplified breast cancer cells and activation of AMPK might provide therapeutic benefit in such cancers., The epidermal growth factor receptor (EGFR) is prevalently amplified or overexpressed in distal colorectal cancers., EGFR mutation-derived NSCLC patient carrying BIM deletion polymorphism had a shorter progression-free survival., Our study suggests that telomerase (TERT)and telomere function may be essential for carcinogenesis of EGFRmut(+) non-small cell lung cancer, These observations suggest that not only ERK1/2 but also Akt activity is essential to maintain Ets-1 in an active state., Continuation of EGFR inhibitor gefitinib after radiological disease progression on first-line gefitinib did not prolong progression-free survival in patients who received platinum-based doublet chemotherapy., LRIG1 is frequently methylated in human CRC and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR/AKT signaling, increased expression of Flot-2 and EGFR in non-small cell lung cancer patients is inversely proportional to the disease prognosis., EGFR and IGF-1R appear to be overexpressed in a subset of ampullary adenocarcinomas and strong membranous expression of EGFR is an independent predictor for overall survival in patients with AA., we observed that EGFR expression was directly involved with poor prognosis of tamoxifen-treated breast cancer patients using the GSE1378 date set, Suggest different miRNA expression between EGFR mutation group and wild type group inlung adenocarcinoma., Report EGFR gene amplification/protein expression in squamous cell carcinoma of the vulva., Overexpression of pEGFR and pAKT may predict the response rate in RASw/t patients treated with anti-EGFR mAb., non-small-cell lung cancer (NSCLC) patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) could benefit from the same TKI therapy through months to years of disease control., these results indicate that in HCFs, activation of NF-kappaB by c-Src-mediated transactivation of EGFR/PI3K/Akt cascade is required for TNF-alpha-induced VCAM-1 expression., Low-dose erlotinib is not recommended for fit patients with NSCLC harbouring EGFR mutations., The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR)., The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking., Molecular marker expressions of both EGFR and p53 were found significantly associated with overall response, survivals and quality of life in oral squamous cell carcinoma patients., results indicate that a divergence in AP-1 regulation determines cellular changes of breast cancer cells stimulated by ErbB receptors, EGFRL858R mutation in circulating DNA is a negative prognostic biomarker in non-small cell lung carcinoma patients., we show that miR-205-5p directly regulates the expression of p63 which is in turn involved in the EGFR expression suggesting a miR-205/p63/EGFR regulation., Letter/Case Report, P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway., Overexpression of miR-200a in non-small lung cancer cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion., Serum COX-2 level could help predict the responses of EGFR-protein kinase inhibitors and the PFS in patients harboring EGFR mutations., HER2 and PTEN expression appears as early as the 9-12 weeks period in the digestive tract, but HER2 expression decreases in the 21-24 weeks period and then disappears. EGFR appears only during the 13-16 weeks period and p53 is strong until week 21., rare mutation in a patient with lung adenocarcinoma successfully treated with gefitinib, Lung cancers harboring exon 18 mutations should not be overlooked in clinical practice. These cases can be best treated with afatinib or neratinib., PIK3CA mutation acquisition is related to patient age and EGFR expression., Opioid receptor delta-mediated activation of ERK1/2 is via ligand-specific transactivation of EGFR., Our findings indicate that EGFR inhibitors may reactivate oxidative phosphorylation of cancer cells and provide a mechanistic clue for the rational combination of agents targeting EGFR-dependent proliferation and glucose metabolism in cancer therapy, Meta-analysis/Review, we demonstrate a simple and efficient method to detect various exon 19 deletion mutations of EGFR using a single probe set comprising of an oligo-quencher (oligo-Q) and a molecular beacon (MB)., The MZI-IDA sensor system is proved to be capable of fast and accurate detection of the L858R mutation of EGFR gene in clinical samples. This may greatly help the clinicians develop an appropriate treatment plan., EGFR mutations are associated with lung cancer., study provides a new molecular mechanism to regulate EGFR signaling through modulation of MIG6 by DNAJB1 as a negative regulator., mutations are associated with survival outcomes in advanced lung cancer, SUMO-1 modification may affect the transcriptional activity of EGFR, Tyr1068-phosphorylated EGFR predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer., This study aims to evaluate the incidence of liver metastasis in a single population and look for potential correlations between EGFR mutations, liver infiltration and clinical outcomes., Both approaches were specific and sensitive for EGFR mutational analysis., ubiquitylation and interaction with AP-2, contribute to EGFR endocytosis via clathrin-coated pits in a stochastic fashion, WM130 could inhibit cell proliferation, invasion, migration and induced apoptosis in HCC cells by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways., Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway., in the NMA cases, none of these factors was statistically significant. In a univariate analysis, neither EGFR nor E-cadherin expression showed a significant impact on disease-free or overall survival., This study showed that the ubiquitination of EGFR in the presence of Cbl and Grb2 on three active sites displays a threshold effect as a function of EGF concentration., Data report rare EGFR mutations in patients with non-small cell lung cancer of unknown clinical significance., we have demonstrated for the first time that the EGFR-T790M-mutation occurs in primary human breast cancer patients. In the present study the EGFR-T790M mutation was not accompanied by any simultaneous EGFR-activating mutation, data suggest one-step screening platform for KIF5B-RET as well as EGFR, K-RAS, ALK oncogenic mutations be necessary for lung adenocarcinoma patients, EGFR T790M is associated with drug resistance in Non-Small-Cell Lung Carcinoma., oncogenic EGFR kinase inhibition triggers release of exosome-like extracellular vesicles and impacts phosphoprotein and DNA content, EGFR and TGF-alpha can be used as predictive markers for activity, fibrosis, and carcinogenesis in chronic hepatitis C patients., Crystal structures of human EGFR-Mig6 complexes show how Mig6 rearranges after phosphorylation by EGFR to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation., Data show that macrophage migration inhibitory factor (MIF) binds to the extracellular domain of epidermal growth factor receptor (EGFR)., we discuss ligand-independent EGFR signal transduction by oncogenic EGFR mutants and EGFRwt, and review the interplay between EGFRwt and EGFRvIII, Twenty-five EGFR-activating mutations (G719S, G719A, G719C, S768I, L858R, and L861Q and 19 mutations of exon 19-Del) were analyzed;none of the EGFR-activating mutations studied was found being associated with triple-negative breast cancer in China, Study shows that Srx plays a critical oncogenic role to promote cell invasion and metastasis, which is at least partially due to its stimulation of the MAPK pathway through EGFR deacetylation., Results found that plasma soluble EGFR was significantly decreased in the non-small cell lung cancer (NSCLC) patients group as compared to the control group, and inhibits growth and migration of NSCLC cells in vitro., both EGFR and EMMPRIN proteins are potential targets for cancer therapy and EMMPRIN can be used as a prognostic marker of a more aggressive biological behavior in patients with head and neck squamous cell carcinoma, EGFR exon 18-21 mutations not found in Iranian prostate adenocarcinoma patients., in H2170 cells and H1975 cells, simultaneous inhibition of key Wnt or mTOR pathway proteins in addition to EGFR and c-Met may be a promising strategy for overcoming EGFR and c-Met TKI resistance in NSCLC patients., In summary, our results showed that negative HCRP-1 expression is an independent prognostic factor for RCC patients., Report EGFR gene amplification in selected cohort of patients with pulmonary metastases of malignant melanoma and prognostic implications., Results indicate that monoclonal antibody-dendriplexes represent a great potential to be used as efficient targeted gene delivery carriers in EGFR-overexpressing tumor cells., High expression of COX-2, EGFR, and VEGF is an unfavorable prognostic factor in ESCC, and could be used as a poor prognosis indicator for the ESCC patients., Review/Meta-analysis, Data suggest that Src kinases inhibitors may act with different mechanisms in non-small cell lung cancer (NSCLC) depending on EGF receptor (EGFR)/Ras protein (Ras) mutational profile., we describe the generation of CARs able to tune T-cell activity to the level of EGFR expression in which a CAR with reduced affinity enabled T cells to distinguish malignant from nonmalignant cells, ErbB2 and EGFR have previously been considered as undruggable targets for CART cells., Digital PCR analysis of plasma is feasible and accurate for detection of T790M mutation in NSCLC that becomes resistant to treatment with EGFR-TKIs., The smoking status as a predictor of the efficacy of gefitinib in patients with NSCLC harboring activating EGFR mutations., Epidermal Growth Factor Receptor Mutations in Serum is associated with response to Erlotinib for Advanced Non-Small-Cell Lung Cancer., These results suggest that targeting the production of CXCR4 and blocking the CXCL12-CXCR4 pathway might be effective strategies for treating NSCLCs harboring a specific type of EGFR mutation., EGFR may be involved in early stage in development of pancreatic ductal adenocarcinoma., Case Report, A positive correlation between EGFR mutational/amplification status and invasive capacity., HER2 and EGFR gene copy number gains may play an important role in the progression of carcinoma ex pleomorphic adenoma, in particular ductal-type CXPAs., EGFR expression and methylation levels were closely related to cancer cell pathological type and stage in NSCLC patients., demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4, This article reviews the research into methods of targeting acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) therapy, including third-generation EGFR TKIs that target the T790M resistance mutation and other agents in development. [review], These findings suggest that activation of EGFR in ovarian cancer cells during platinum treatment contributes to the development of platinum resistance., single EGFR exon 18 mutations may be an indicator of poor prognosis of lung adenocarcinoma compared with complex EGFR exon 18 mutations or classic mutations, Studies indicate that epidermal growth factor receptor (EGFR) pathway is frequently activated in pancreatic cancer and therefore it is a rational target for new treatments., Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways., prevalence of EGFR mutation (11.9%) detected in our Lebanese population is similar to that observed in the Caucasian population, In NSCLC patients who progressed after first-line EGFR TKIs., Results demonstrate that acquired resistance of colorectal tumour cells to treatment with anti-EGFR mAb ICR62 is accompanied by an increased level of cell surface EGFR, and upregulation of phosphorylated HER-2 and HER-3 proteins., EGFR mutations are indicators of malignant transition in the progression to lung adenocarcinoma., EGFR mutation is associated with response to chemotherapy in Non-Small-Cell Lung Carcinoma., Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility., concluded that EGFR can be activated intracellularly by FASN-dependent palmitoylation, Three out of the 110 SNPs were found to be associated with HCV outcome (P-values<0.03). rs11506105 in EGFR (epidermal growth factor receptor gene), and rs11881222 and rs12979860 in IL28B (interferon-lambda3 gene)., EGFR and KRAS Mutations are associated with ALK-Positive Lung Adenocarcinomas., integrin alpha6beta4 stimulates invasion by promoting autocrine EGFR signaling through transcriptional up-regulation of key EGFR family members and by facilitating HGF-stimulated EGFR ligand secretion, EGF-induced sodium influx regulates EGFR trafficking through increased microtubule acetylation., The loss of expression of EGFR and retinoblastoma (Rb) in the LCNEC., The association may be most relevant in EGFR mutation-positive patients., EGFR Mutations are associated with Non-Small-Cell Lung Cancer., Proton-pump positive parietal cells were mostly EGFR immunoreactive whereas very few pepsinogen I (PGI)-positive chief cells were EGFR positive., Data suggest that tyrosine-phosphorylated CaM (calmodulin) elicits strong up-regulation in ligand-dependent activity of EGFR (epidermal growth factor receptor) in vitro; for these studies CaM was phosphorylated by c-Src (cellular sarcoma kinase)., The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer, Data indicate a positive Correlation between tumor Cell tntravasation and epidermal growth factor receptor (EGFR) expression., EGFRvIII expression does not alter radiosensitivity with or without anti-EGFR treatment, 21 novel somatic variants in exons 18-21 of EGFR in adult Argentinean patients affected with non-small cell lung cancer were reported, Intratumor Heterogeneity of ALK-Rearrangements and Homogeneity of EGFR-Mutations in Mixed Lung Adenocarcinoma, GSTP1 tyrosine phosphorylation by EGFR controls the interaction of GSTP1 with JNK and Apoptosis in Brain Tumor Cells., Higher cell free EGFR mRNA expression may play an important role in causing distant metastases and reducing overall survival of Non-Small Cell Lung Cancer patients in the Indian population., EGFR expression was studied by immunohistochemistry and EGFR mutations (exons 18-24) by PCR cloning and sequencing., It blocked activation of EGFR, HER2 and downstream Akt and Erk., Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer., The study presents the results of an investigation of the spatial structure and mobility of the EGFR transmembrane domain and juxtamembrane regions in various membrane-like environments., EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified., The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer., Data show that lenalidomide increased the antitumor effect of 3C10-CAR T cells on epidermal growth factor receptor variant III (EGFRvIII)-expressing glioma cells., EGFR mutations remodel the activated enhancer landscape of glioblastoma multiforme, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regulatory network in vitro and in vivo., The anti-EGFR/irinotecan-based regimens were associated with the highest pR., This study demonstrates that high serum COX-2 levels may indicate EGFR mutations in non-small cell lung cancer., Data suggest that the combination of peritumoral Cbl and EGFR serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence., Retreatment anti-EGFR agents were cetuximab (n = 76) or cetuximab plus erlotinib (n = 13). The median interval time between prior and retreatment regimens was 4.57 months (range, study emphasized that the AXL and EGFR receptor tyrosine kinases were coexpressed in a subgroup of treatment-naive lung adenocarcinomas with or without EGFR mutations, These results suggest that the iEA index or a combination of polymorphisms in EGFR and ANXA3 may serve as predictive factors of drug response, and therefore could be useful for optimal selection of chemotherapy regimens., a variety of EGFR structures have identically good performance in the scoring and ranking of known inhibitors, indicating that the choice of the receptor structure has little effect on the screening., EGFR and KRAS mutations were low in lung squamous cell carcinomas, and had no significant correlation with clinical features., These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF signaling., Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway., Mitochondrial translocation of EGFR may enhance cancer invasion and metastasis through regulating mitochondria dynamics in non-small cell lung carcinoma., data indicate that inhibition of Notch cleavage may not affect cell number in the presence of EGFR mutations and that EGFR may affect Notch signalling suggesting that a dual inhibition of these pathways might be promising in NSCLC, EGFR DNA methylation levels significantly increased following NSCLC malignancy upgrading, and showed negative correlation with mRNA expression., Data identified several cases of complex EGFR mutations, and concomitant EGFR mutations and ALK rearrangements in non-small cell lung cancer, Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR/NF-small ka, CyrillicB/AP-1 signaling pathways in human endothelial cells., Suggest that EGFR/ERK1/2 signaling pathway but not cholinergic pathway involved in chlorpyrifos-induced colorectal adenocarcinoma cell growth., Findings indicate the role of CMTM7 protein in the regulation of epidermal growth factor receptor (EGFR)-AKT proto-oncogene protein signaling in tumor cells, and as a molecule related to Rab5 GTP-binding protein activation., Results showed that EBP50 specifically scaffolds the interaction of PTEN with EGFR and enhances the inhibition of PTEN on EGF-induced AKT activation. These results elucidated a novel mechanism regulating EGF-induced AKT signaling., EGFR Mutation is associated with response to chemotherapy in Non-Small Cell Lung Cancer., the discovery of EGFR mutations and ALK rearrangements has enabled the identification of patients who are more likely to benefit from a specific drug., This study describes a pro-metastatic EGFR/Src-dependent beta4 integrin/FAK complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer., Finally, a crystal structure of EGFR in complex with a primed Shc1 peptide reveals the structural basis for EGFR substrate specificity., Age and N stage might be considered in predicting EGFR mutation type in NSCLC., COPD-related NSCLC patients exhibited low prevalences of EGFR mutations and ALK rearrangements compared with the non-COPD group. Further studies are required regarding the molecular mechanisms underlying lung cancer associated with COPD, EGFR knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone., Two key biological processes for progressive hearing loss, TrkA signaling pathway and EGF receptor signaling pathway were significantly and differentially enriched by the two sets of allele-specific target genes of miR-96., these data indicate that R198/R200 methylation of the EGFR plays an important role in regulating EGFR functionality and resistance to cetuximab treatment., Detection of T790M with plasma DNA was correlated with EGFR mutation type, exon 19 deletions and tumor progression, Activation of the epidermal growth factor receptor (EGFR) pathway was observed in recurrent tumors., Data show that 11/105 patients failed all molecular analysis, In lung adenocarcinomas, EGFR mutation was higher in female and non-smoking patients, KRAS mutation only in patients with wild-type EGFR gene was higher., A study evaluating the effect of small molecule T315 on EGFR degradation and therapeutic efficacy in vitro and in vivo using a mouse xenograft model found T315 effective at suppressing cancer cell proliferation, verified by combining T315 with afatnib., we identify that EGFR mutations might associate with more aggressive tumor progression than the wild types in non-small-cell lung cancer, EGFR L858R mutation and 2nd-line chemotherapy caused a poor outcome., This ubiquitin-mediated switch in EGFR trafficking is a uniquely suited solution to suppress spontaneous activation while maintaining responsiveness to EGF., Thus, this study demonstrated effective chemotherapeutic potential of SFE by inducing apoptisis as well as inhibiting migration and their preliminary mechanism for human gastric cancer management., use of sorafenib has been ineffective in the management of advanced Colorectal cancer (CRC) patients with KRAS mutation, combination of selective BRAF inhibitors plus EGFR inhibitors may represent a good therapeutic strategy in BRAF-mutant CRC., mEGFR are associated with higher response rate (RR) to brain metastasis radiotherapy than wild-type EGFR/RAS or mKRAS., MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells by inactivating Akt and Erk1/2 signaling and targeting EGFR., Evaluation of GPER1, EGFR and CXCR1 mRNA/protein expression may be helpful in differential diagnosis of malignant follicular thyroid carcinoma and benign follicular thyroid adenoma., The frequency of EGFR mutations in the cancers that expressed P-gp, LRP, or both P-gp and LRP was significantly higher than that in cancers that did not express P-gp or LRP., Lung adenocarcinomas with L858R mutation, rather than exon 19 deletion or wild-type EGFR gene, prefer to locate over the upper lungs, EGF stimulates loss of FOXO3/SIRT6, which is blockaded by the inhibition of upstream pathways as well as lipid synthesis, revealing existence of a negative regulatory loop between LDs and FOXO3/SIRT6., Findings of frequent mutations in CDKN2A, NOTCH1, PIK3CA, and EGFR (all in excess of 20%) point to potential therapeutic avenues. Trials of targeted therapies directed toward these mutations should be explored., overexpressed EGFR significantly correlated with JAK2 and PD-L1 expression in a large cohort of head and neck cancer specimens., Study shows that high EGFR protein expression and exon 9 PIK3CA activating mutations are independent prognostic factors in triple negative breast cancers., These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha in the EGFR endocytosis pathway., NF-kappaB and EGFR expression was significantly elevated during the occurrence and development of esophageal carcinoma, and expression of these factors appears to be correlated with cancer progression., These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells, Report using biosensing techniques to monitor dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation., Our data suggest the possibility of using macrolides as 'chemosensitizers' for EGFR-TKI therapy in pancreatic cancer patients to enhance non-apoptotic tumor cell death induction., activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is overexpressed in many types of human cancer., UCH-L1 plays a crucial role in modulating the degradation of EGFR and promoting malignant properties in multi-drug resistant breast cancer, plasma EGFR mutation status before tyrosine kinase inhibitors therapy might be of prognostic significance for TKIs-treated non-small cell lung cancer patients with tumor tissue EGFR mutation, The existence of a tight association between SHP2 and EGFR expression in tumors and cell lines further suggested the importance of SHP2 in EGFR expression., In summary, this study identified a novel role for EGFRvIII in hypoxia tolerance, supporting an important link between hypoxia and subcellular localization alterations of the receptor., Data show that Prolyl isomerase Pin1 is expressed in an epidermal growth factor receptor (EGFR)-mutant lung cancer tissue that has undergone partial epithelial-mesenchymal transition (EMT) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs)., P53, EGFR and MGMT could play a role in the occurrence, development and deterioration of glioma., Our data imply that at sites of tissue damage, when inflammatory mediators are present, for example in lungs of COPD patients, MSCs become more potent inducers of repair, in addition to their well-known immune-modulatory properties., In operated pancreatic adenocarcinoma, incidence of mutations was, showed that one of these intermediates, fructose 1,6 bisphosphate (F1,6BP), directly binds to and enhances the activity of the EGFR, no significant difference in level in peritoneal lavage fluid of patients with advanced pancreatic cancer compared to the control group, Study group precludes statistical significance. EGFR mutations seem to correlate with TTF1 status., Inactivation of the EGFR with a blocking antibody decreased the S. aureus-mediated IL-1alpha and IL-1beta induction in primary keratinocytes., Meta-analysis, ATM inhibition may facilitate the gefitinib-dependent repression of the phosphorylation of EGFR and/or its downstream factors, to exert anticancer effects against non-small-cell lung cancer cells with the sensitive EGFR mutation, High EGFR expression was an independent risk factor for shorter overall survival (OS), whereas high HER3 expression was associated with a borderline significant trend towards a longer OS., an "oncogene swap" from EGFR to MET is a novel resistant mechanism to the EGFR-TKI. This novel mechanism should be considered in order to avoid futile inhibition of the original oncogene., PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs., Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes., while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 and ErbB4 expression., Higher mutation fraction was associated with greater EGFR TKI response rate (odds ratio 1.58, 95% CI = 1.21-2.07, P = 0.0008), longer TTF (hazard ratio 0.80, 95% CI = 0.68-0.92, P = 0.003) and better OS (hazard ratio 0.81, 95% CI = 0.67-0.99, P = 0.04)., Our data confirmed that exon-20 insertions confer poor response to all known EGFR inhibitors, and suggested that these models can be utilized to facilitate the discovery of new therapies targeting NSCLC harboring exon-20 insertions, Data demonstrated the significance of PR extranuclear signaling through PPD interactions in EGFR-mediated proliferation and signaling in NSCLC., Data show that grape seed proanthocyanidins could inhibit cell proliferation, invasion and migration of A549 cells, which might be related to the down-regulation of epidermal growth factor receptor and N-cadherin and the up-regulation of E-cadherin., Distinct patterns of receptor-adaptor complex formation, site-specific phosphatase activity, and tight integration of positive and negative feedback occur in the early periods of EGFR signaling., Targeting ERBB1 signaling suppresses melanoma tumor growth., EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor endocytosis in HeLa cells, beta3-alphaC deletions are activating mutations in EGFR. These deletions are resistant to the alphaC 'Out' inhibitor lapatinib., Suggest that EGFR gene copy number gain-positive tumors represent an HPV-negative, aggressive subgroup of oropharyngeal squamous cell carcinoma., Netrin-1 enhanced infectivity of hepatitis C virus particles and promoted viral entry by increasing the activation and decreasing the recycling of EGFR., measurements comprising the receptors EGFR, ERBB3 (HER3), and the cyclin-dependent kinase inhibitor p27 (CDKN1B) was found to accurately predict dependence on PI3K/AKT vs. MAPK/ERK signaling axes in HER2+ cancers, results suggested that C/EBPalpha-saRNA successfully inhibited HCC metastasis by inhibiting EGFR/beta-catenin signaling pathway mediated EMT in vitro and in vivo, EGFR expression and activation was not found to be an independent prognostic factor in breast cancer survival outcome., our data suggest roles for HRAS and EGFR as drivers in a subset of poroma and porocarcinoma., HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study, The pemetrexed-carboplatin combination was effective and well-tolerated in patients with EGFR-wild-type non-squamous NSCLC., Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma, Studied prevalence of EGFR activating mutations in squamous cell carcinomas and adenosquamous carcinomas of the lung in patients of the Southern Bulgarian region., Overexpression of MMP2 and EGFR were independent risk factors for mortality in non-small cell lung cancer patients., Consecutive patients with advanced/recurrent non-small cell lung cancer (NSCLC)harboring activating EGFR mutations were treated with platinum combined with Pemetrexed,
OMIM_DISEASE Adenocarcinoma of lung, response to tyrosine kinase inhibitor in, Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, Nonsmall cell lung cancer, susceptibility to, Inflammatory skin and bowel disease, neonatal, 2,
SP_COMMENT catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Defects in EGFR are associated with lung cancer [MIM:211980]., function:Isoform 2/truncated isoform may act as an antagonist., function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin., miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation., online information:EGFR entry, PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur., PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily., similarity:Contains 1 protein kinase domain., subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1., tissue specificity