Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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decorin(DCN) decorin(DCN) Related Genes Homo sapiens
CHROMOSOME 12,
CYTOBAND 12q21.33,
ENSEMBL_GENE_ID ENSG00000011465,
ENTREZ_GENE_ID 1634,
GENERIF_SUMMARY decorin can disrupt glucose and TGFbeta/Smad-dependent transcription in mesangial cells through a mechanism that involves an increase in Ca(2+) signalling, the activation of Ca(2+)/calmodulin-dependent protein kinase II and phosphorylation of Smad2, has a GAG chain and affinity to collagen, binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope, decorin supports adhesion and activation of human platelets, The 179 allele variant of the Decorin gene is related to a slower progression of diabetic nephropathy in type 1 diabetic patients with albuminuria and receiving antihypertensive therapy, the glycosaminoglycan chains in decorin are chondroitin, chondroitin 4-sulfate or chondroitin 6-sulfate, carbohydrate recognition domains of SP-D interact with the dermatan sulfate moiety of decorin via lectin activity and the core protein of decorin binds the collagen-like region of SP-D, might play a pivotal role in tissue remodeling by acting on the balance between extracellular matrix synthesis and degradation, Decorin expressed in oral cancer may have lost its ability to inhibit TGF-beta signaling and activate epidermal growth factor receptor signaling pathways because of aberrant nuclear localization., decorin is a monomer in solution and is a monovalent ligand for various extracellular matrix proteins, growth factors, and cell surface receptors, Continuous infusion of recombinant human decorin into acute stab injuries of adult rat spinal cord results in major reduction in astrogliosis, macrophage accumulation and deposition of chondroitin sulfate proteoglycans within spinal cord scar tissue., IL-10 and IL-6 induce decorin mRNA transcription, but additional signals from the extracellular matrix are necessary for its translation., Clones derived from a fibrotic patient secreted 3-fold greater amounts of decorin than those from a control subject; furthermore, there was a negative correlation between proliferation and synthesis of decorin, decorin secreted by MRC-5 cells is a dermatan sulfate proteoglycan; glycosaminoglycans from the purified protein were treated with chondroitinases and the resulting disaccharides were analyzed, dynamically increased expression of decorin in the choriodecidual membrane during parturition may be a part of the uterine preparation for labor, decorin not only can regulate collagen fibril formation but that it also can act as an intermediary between type I and type VI collagen, Malignant cells can actively influence the composition of the extracellular matrix through TGFbeta1 and other soluble factors., investigates the complex composed of one decorin core protein and one collagen molecule in order to obtain their binding force and binding stiffness, Subsequent sequencing of candidate genes revealed a frameshift mutation in the DCN gene (c.967delT) that encodes for decorin, predicting a C-terminal truncation of the decorin protein, 505 transcripts are differentially expressed in the thyroid carcinoma cell lines., a novel collagen binding domain in decorin acts cooperatively with leucine-rich repeat 4 to mask the alpha2beta1 integrin-binding site on collagen, an important sequence for the phagocytosis of collagen fibrils, decorin peptides from the leucine-rich repeat 5 region inhibit angiogenesis, decorin is not required for cell survival, Decorin causes EGFR internalization via caveolae, decorin secretion regulation has several components, including appropriate substitution with N-linked oligosaccharides and factors involved in glycosaminoglycan synthesis, beta ig-h3 can differentially modulate the aggregation of collagen VI with biglycan and decorin, decorin is a potent trophic factor that protects neuronal progenitor cells and glioma cells from oxygen and glucose deprivation, reduced galactosyltransferase I(beta4GalT-7)activity resulting in defective glycosylation of decorin and biglycan may be responsible for the complex molecular pathology in beta4GalT-7 deficient Ehlers-Danlos syndrome patients, Data show that decorin protein core inhibits tumor xenograft growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation., hevin can modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly, This is the second family with congenital stromal corneal dystrophy of the cornea in which a frame shift mutation in the decorin gene has been detected., Decorin mRNA was expressed in patients with early B-cell CLL, low expression was found in advanced clinical stages a significant higher expression in patients with non-progressive CLL type., decorin and biglycan are increased in DMD skeletal muscle and may have a role in muscle response to dystrophic cell damage, data demonstrate that decorin can regulate fibrin organization and reveal a novel mechanism by which extracellular matrix components can participate in hemostasis, thrombosis, and wound repair, The purified recombinant human decorin (rhDecorin) significantly inhibited the proliferation of LX-2 cells, a human HSC cell line, stimulated by TGF-beta1., decorin in the umbilical cord vein wall is elevated in pre-eclampsia in comparison to the corresponding control vessels, Altered expression of decorin mRNA in the different dermal strata and a decrease in the collagen-to-decorin ratio inflicted by both age and ultraviolet irradiation affect collagen bundle diameter and subsequently the mechanical properties of human skin., Decorin may play an important role in cases of vulvar lichen sclerosus, decorin is taken up by more than one endocytic pathway; uptake depends on EGFR signaling rather than trafficking along the same pathway, The results suggest that a high level of decorin mRNA might be associated with the reduced content of collagen type III, resulting in a less flexible form of extracellular matrix in the connective tissue in stress urinary incontinence and prolapse., analysis of distribution patterns of decorin and biglycan and their relation with collagen, In addition, no pathogenic sequence variations were found in DCN, DSPG3, LUM, PITX2 and FOXC1, which have also been implicated in corneal and anterior segment dysgenesis., Data show that at early stages of fibrillogenesis, the glycosaminoglycan chain of decorin has a reducing effect on collagen fibril diameter., Forced expression of decorin was accompanied by a suppression of alpha-SMA expression, whereas knocking down of decorin expression by RNA interference increased the expression of alpha-SMA., The molecular mechanism of Leucine Rich Repeat 5 reveals that its anti-migratory effect on endothelial cells is mediated by inhibiting VEGF-stimulated endothelial nitric oxide synthase activation and nitric oxide release., induction of decorin expression in angiogenic, as opposed to quiescent, endothelial cells promotes a motile phenotype in an interstitial collagen I-rich environment by both signaling through IGF-IR and influencing alpha2beta1 integrin activity, Decorin is likely to possess a suppressive effect on human tumor angiogenesis in vivo and certainly provides a usable biomarker for distinguishing between benign and malignant vascular tumors in patients., The antimyeloma effect of decorin involved direct induction of apoptosis and activation of p21(WAF)., analysis of an exception to the decorin oncosuppression model using human osteosarcoma cells, Functional analysis of human decorin promoter identified an imperfect inverted repeat DNA motif, IR8 (-2313TGGTCAtagtgtcaTGACCT-2294), as a likely FXR-responsive element that is involved in decorin regulation., Multiple core-protein species were detected for decorin, biglycan, lumican and keratocan in the degenerate osteoarthritic articular cartilage and menisci., Excess decorin, biglycan, and versican may be associated with the remodeling of other matrix components in myxomatous mitral valves., Decorin can directly boost the ability of neurons to extend axons within inhibitory chondroitin sulfate proteoglycans or myelin- rich environments., study concludes expression of decorin may be involved in the differentiation of colonic polyps and reduced expression of decorin may abrogate the defensive potential of stromal tissue and promote the development of common types of colon carcinoma, Genetic variation in decorin gene is associated with breast cancer., Report expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity., Decorin suppresses intracellular levels of beta-catenin, a known downstream Met effector, and inhibits Met-mediated cell migration and growth, Asporin competes with decorin for collagen binding., a novel role for decorin in the reduction or prevention of tumor metastases in this breast cancer model and could eventually lead to improved therapies for metastatic breast cancer., KRAS mutations correlate with expression of DCN and TPM1 in colorectal cancer., Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction., DCN is a negative regulatory protein inhibiting hepatoma carcinoma cell proliferation through inhibiting cell cycle and inducing apoptosis., Our results suggest that decorin and TGF-beta1 may have a fundamental role in the pathogenesis of nephrogenic systemic fibrosis., Three isoforms of BMP1 ranging from the shortest BMP1-5 to the longest (mTLD, inefficient at processing procollagen in vitro) were all shown to be capable of removing the highly conserved propeptides from both proDCN., Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region., Expression of decorin in healthy human breast tissue during menstrual cycle., Thus, decorin accumulation appears to contribute to the stromal opacities that are characteristic of Congenital stromal corneal dystrophy (CSCD)., The results of study suggest that decorin-gene transfer effectively prevents TGFbeta-driven transformation of keratocyte and corneal fibroblast to myofibroblasts., the first study to demonstrate reduced decorin in idiopathic fetal growth restriction., Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells., The structure of the GAG (glycosaminoglycan) chain of recombinantly expressed decorin proteoglycan was examined using a combination of intact-chain analysis and domain compositional analysis., study shows decorin blocks several biological activities mediated by Met signaling axis; these effects were mediated by downregulation of noncanonical beta-catenin levels; Myc was downregulated by decorin; phosphorylation of Myc at threonine 58 was induced, Decorin demonstrated distinctive localization relative to nodules within calcified aortic valves., Oxidative stress-mediated decorin GAG chain synthesis triggers TGF-beta signaling and mineralization of vascular smooth muscle cells in vitro., expression levels of p57(KIP2) and TGF-beta 1 associated with histological type of lung cancer; expression levels of decorin and p57(KIP2)associated with lymphatic invasion; increased expression of decorin and p57(KIP2) correlated with increased survival, Biglycan and decorin reduced the proliferation of pre-adipocytes, partly by induction of apoptosis. Furthermore, the anti-proliferative capabilities of decorin and biglycan were nullified with removal of GAG side-chains., these data suggest that decorin should play a significant role in keratinocyte terminal differentiation, cutaneous homeostasis and dermatological diseases., Data show that elevated levels of versican were correlated with higher tumor grade and invasiveness in carcinomas with MD and MAMCs, whereas increased amounts of decorin were associated with in situ carcinomas in MAMCs., Mast cell tryptase stimulates production of decorin by human testicular peritubular cells, Wild type N-ras appears to mediate its anti-malignant effect by downregulating decorin expression., decorin loss may contribute to increased IGF-IR activity in the progression of bladder cancer, Nuclear localized decorin plays an important role in migration and invasion of oral cancer cells., A novel frameshift mutation in decorin gene in stromal dystrophy, hereditary., Decorin protein is significantly down-regulated in non-small cell lung cancer tissue., Loss of decorin and E-cadherin accelerated colon cancer cell growth and invasion in Dcn(-/-) mice., The concentration of aggrecan, biglycan, and decorin was determined in six regions of the human supraspinatus tendon., These analyses identified decorin (DCN) and endoplasmin (HSP90B1) which play important roles regulating the tumour microenvironment and in pathways related to tumorigenesis., Data show that granzyme B (GrB) liberated TGF-beta1 from substrates decorin, biglycan and betaglycan., immunohistochemistry. Gene expression from mRNA extracted from cartilage showed high levels of decorin expression, likely associated with the large, complex tubular structures running through this cartilage type., The level of MMP-2 activation was significantly elevated in tissues with Dupuytren's contracture. RT-PCR demonstrated significantly higher expression of MMP-2, TIMP-2, TGF-beta1, and DCN mRNA in the pathological tissues, There is a dynamic reduction in Decorin level the days following ischemic stroke, and the decrement persists at least the first 2 weeks, study found a novel point mutation in the decorin gene in a patient with congenital hereditary stromal dystrophy and his mother, The expression of collagen type IalphaI, collagen type III and decorin could be detected in tenocyte-like cell cultures using both enzymatic digestion and cell migration methodology., The spatio-temporal expression of Decorin, Semaphorin6D, SPARC, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human., Data indicate that decorin is involved in folliculogenesis/oogenesis, ovulation, and luteal phase support., study demonstrates that stromal decorin expression decreases during the progression of breast cancer; reduced decorin expression may facilitate tumorigenesis, tumor invasion and/or tumor growth, In human breast tissue only cells of the original stroma are capable of decorin gene expression. Transduction of decorin in decorin-negative human breast cancer cells markedly modulates the growth pattern of these cells., Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model., It was shown that plasma resistin was associated with some tag SNPs in decorin in the general Japanese population., DCN seems to be equally expressed at the gene level in the BMB in our population.Its expression in our study was positively correlated to MET expression, suggesting a compensatory elevation of DCN with increased HGF/MET signalling., Decorin lacking c-terminal repeat is retained intracellularly, its accumulation triggering endoplasmic reticulum stress that results in abnormal synthesis and secretion, leading to congenital stromal corneal dystrophy., Both lumican and decorin are involved in collagen fibrillogenesis and stability., decorin induced VEGFR2-dependent mitochondrial fragmentation and loss of mitochondrial membrane potential, findings have shown that MMP-8 is able to modify the metastatic potential of breast cancer cells because of its ability to proteolytically cleave decorin and regulate miR-21 levels, Periductal myxoid stroma and reduced periductal decorin expression seem to be prognostic for overall ipsilateral locoregional recurrence in ductal carcinoma in situ, This age-dependent alteration of decorin GAG may contribute to skin fragility of elderly people., Polymorphonuclear cell proteases, especially neutrophil elastase, degrade decorin, and this degradation renders collagen fibrils more susceptible to MMP-1 cleavage., immunolocalization of decorin and biglycan in samples of first-trimester and term placentas, placenta accreta, invasive mole, and choriocarcinoma, Overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro., human bladder cancer cells in vitro were negative for decorin expression., Micro vessel density and VEGF-A expression were significantly associated with reduced decorin expression in tumor stroma suggesting, decorin as angiogenic modulator in oral squamous cell carcinomas., The results of our study showed that the presence of increased DCN levels in women with fetal growth restriction could contribute to pathogenesis of the disease., decorin-mediated inhibition of cholangiocarcinoma cell growth, migration, and invasion and promotion of cell apoptosis might be through regulation of the expression of E-cadherin in vitro., Decorin differentially modulates the activity of insulin receptor isoform A ligands., We present the clinical, histopathological, and molecular genetic assessment of a Chinese family with congenital stromal corneal dystrophy in which a novel DCN mutation was identified., we identified the methylated +58CpG in DCN 5'-UTR associated with reduced expression of DCN mRNA, thereby downregulating E-cadherin in NSCLC cells with high metastatic potential., AMPK is downstream of VEGFR2 and inhibition of AMPK signaling abrogated decorin-evoked autophagy., The results suggest that regions within decorin is associated with ACL injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties., The targets of DCN include genes that play important roles in angiogenesis and cellular growth and may contribute to the pathogenesis of fetal growth restriction., decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle., Results demonstrate that DCN, a small leucine-rich proteoglycan, localizes to subregions of pathologically thickened arteries affected by CADASIL, A role for decorin and p-Smad-2 in the pathophysiology of fetal membranes and adverse pregnancy outcomes., Decorin induced by dienogest appears to play a crucial role in suppressing endometriosis by exerting anti-proliferative effects and inducing cell cycle arrest., Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone, Our results reveal the molecular details of the periostin-decorin complex in both phyllodes tumor tissues and breast cancer cells; this interaction may represent a novel target for anti-cancer therapy, findings indicate that decorin may indirectly act as an antagonist to MM cell survival and that the interplay between MM and decorin may be an important target to explore in manipulating the tumor niche to inhibit tumorigenesis, decorin plays crucial roles in non-small-cell lung cancer against carcinogenesis and progression., DCN is a key regulator for chemoresistant mechanisms., Defective Proteolytic Processing of Fibrillar Procollagens and Prodecorin Due to Biallelic BMP1 Mutations Results in a Severe, Progressive Form of Osteogenesis Imperfecta., Data show that decorin is not only associated with angiogenesis, but it plays a causal role in this process. Also, depending on the molecular microenvironment where angiogenesis is induced, decorin can either promote or inhibit angiogenesis. [review], decorin expression and immunoreactivity in normal and malignant human colorectal tissue, Compared with bone graft and marrow cavity contents, sticking scars had the highest expression of BMP-2 while bone grafts had the highest expression of DCN., An emerging concept that multiple proteases, especially those produced by inflammatory cells, are capable of cleaving DCN suggests that native DCN could be inactivated in a number of pathological inflammatory conditions, Decorin plays a key role in the maintenance of the order in the normal corneal extracellular matrix.,
OFFICIAL_GENE_SYMBOL DCN,
OMIM_DISEASE Corneal dystrophy, congenital stromal,
SP_COMMENT disease:Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance., function:May affect the rate of fibrils formation., PTM:The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin., similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily., similarity:Contains 12 LRR (leucine-rich) repeats., subunit:Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.,