Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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DAVID Functional Annotation Table
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catenin delta 1(CTNND1) catenin delta 1(CTNND1) Related Genes Homo sapiens
CHROMOSOME 11,
CYTOBAND 11q11,
ENSEMBL_GENE_ID ENSG00000198561,
ENTREZ_GENE_ID 1500,
GENERIF_SUMMARY The interaction of VE-cadherin with p120 catenin plays an important role in cellular growth, suggesting that the binding of p120 catenin to cadherins may regulate cell proliferation., Overexpression of delta catenin is associated with prostatic adenocarcinoma, These data reveal a cooperative interaction between p120 catenin and E-cadherin and a novel role for p120 that is likely indispensable in normal cells., roles of p120 as a tumor suppressor or metastasis promoter are discussed (review), Both p120(ctn)-defective tumor cell contacts and p120(ctn)-mediated growth signals appear to contribute to the aggressive spread of pancreatic cancer., study links posttranslational modifications of VEC, beta-catenin, and p120 to the mechanism of thrombin-induced increase in endothelial permeability, The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120., Cellular levels of p120ctn function as a set point mechanism that regulates cadherin expression levels; a major function of p120ctn is to control cadherin internalization and degradation., binding of p120ctn to microtubules is inversely related to its ability to regulate Rho GTPases, differential expression of p120(ctn) and Kaiso mRNA was observed in human coronary artery endothelial cells depending on how laminar shear stress was applied in relation to the wounding process, Cytoplasmic p120ctn may contribute to the invasive phenotype of E-cadherin-deficient breast cancer cells, Galpha12-p120ctn interaction acts as a molecular switch, which regulates cadherin-mediated cell-cell adhesion., in human lymphoblasts, the silencing of one allele is incomplete, E-cadherin-deficiency in metastatic cancer may in some cases be due to p120 downregulation [review], Catenin p120ctn inhibits association of Kaiso with the matrilysin promoter., Overexpression of P-cadherin was strongly associated with cytoplasmic accumulation of one of the catenins, p120ctn, and cadherin switching in pancreatic ductal carcinoma cells., trans-interacting nectin inhibits non-trans-interacting E-cadherin endocytosis through afadin, Rap1, and p120ctn, These results support a model in which the VE-cadherin tail mediates interactions with clathrin-dependent endocytic machinery, and this endocytic processing is inhibited by p120 binding to the cadherin tail., Increased expression of delta-catenin is associated with the down-regulation and redistribution of ECAD and p120ctn in prostatic cancer., results indicate that p120ctn plays an important role in regulating the formation of E-cadherin and -catenin complex, cell apoptosis, cell cycle and hepatoma cell biological function, the degradation of E-cadherin in response to expression of R-cadherin is due to competition for p120(ctn), Membrane-localization and not cadherin interaction is the main determinant in p120 serine-threonine phosphorylation-dephosphorylation, further, the phospho-status had no effect on p120's role in cadherin complex stabilization or cell-cell adhesion., p120 catenin and mesenchymal cadherins are both required for invasiveness of E-cadherin-deficient cells; p120 acts as a rheostat, promoting a sessile cell phenotype associated with E-cadherin or a motile phenotype associated with mesenchymal cadherins., the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation, In this review, p120 catenins function in the cytoplasm as versatile scaffolds that confer specificity to the complex regulation of Rho-GTPases and direct the spatio-temporal control of Rho-signalling., membranous p120 is maintained in invasive squamous cell carcinomas in tumours suggesting that p120 may be important for the collective invasion of tumours cells in vivo, identification of Gli-similar 2 (Glis2) as a novel binding protein for p120 catenin, P120CTN was expressed stongly on the cuboidal cell membrane and cytoplasm of both tumor types. In polygonal cells, expression was decreased and mostly cytoplasmic., Helicobacter pylori infected gastric epithelial cells showed altered distribution/phosphorylation of p120ctn., Cortactin and p120 are shown to directly interact with each other via the cortactin N-terminal region, We show that a fraction of N-cadherin in a complex with catenins is associated with cholesterol/sphingolipid-rich membrane microdomains in aggressive melanoma cells in vitro and experimental melanomas in vivo., These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions., The expression of p120-catenin isoforms was associated with the genomic and transcriptional phenotype of breast cancer cells., findings show that p120ctn is a novel interactor of the desmoglein proteins, and may play a role in desmosome remodeling, the the increased expression of p120 isoform 1 during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas and that the N-terminal domain of p120 is a valid therapeutic target, Report nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction., p120 expression in solid pseudopapillary tumors (SPTs) is abnormal. Loss of E-cadherin is probably consequent on p120 loss or decrease. Aberrations & other alterations of the E-cadherin gene are unlikely to be responsible for loss of E-cadherin in SPTs., Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters., p120-catenin is a key component of the cadherin-gamma-secretase supercomplex, VE-cad gap formation is required for leukocyte transmigration and identify p120 as a critical intracellular mediator of this process through its regulation of VE-cad expression at junctions., p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7, Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas., PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions., VE-cadherin levels are not directly related to N-cadherin levels but may be inversely related due to competition for p120., p120ctn is a unique positive regulator of the gamma-secretase processing of cadherins and a negative regulator of the amyloid precursor protein processing, The extracellular accumulation of delta-catenin in urine supporting its potential utility for non-invasive prostate cancer detection., p120ctn isoforms 1A and 3A differently regulated the adhesive, proliferative, and invasive properties of lung cancer cells through distinct mechanisms., p120-catenin gene knockdown enhances the metastasis of lung cancer cells, Abnormal p120-catenin expression correlates with abnormal E-cadherin expression and specific small GTPase overexpression, which contribute to the malignancy-related to NSCLC., At least one consequence of an increased expression of delta-catenin in human prostate cancer is the alteration of cell cycle and survival gene profiles, thereby promoting tumor progression., p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound p120ctn contributed to RhoA inactivation by favoring p190RhoGAP-RhoA association., Using in vitro infection assays, the authors showed that Helicobacter pylori CagA interacts with E-cadherin, p120-catenin, and c-Met., p120ctn and Kaiso might co-participate in the progression and lymph node metastasis of lung cancer, GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis, pH 6.6 activates Src kinases, resulting in tyrosine phosphorylation of E-cadherin and p120ctn and a weakening of the association of E-cadherin with p120ctn and contributing to the instability of E-cadherin at adherens junctions, In lung cancer, p120ctn isoform 1 over-expression correlated positively with lymph node metastasis, poor differentiation, histological type, & high TNM stage. Expression in metastases was always higher than in the primary tumor., The abnormal expression of E-cadherin and P(120ctn) is closely related to the degree of differentiation, clinical stage and cervical lymph node metastasis in nasopharyngeal carcinoma., Cells overexpressing delta-catenin have less p120-catenin than control cells at the cell-cell interface, causing the relocalization of p120-catenin from the plasma membrane to the cytosol. CTNND1 binding to E-cadherin adversely affects CTNND2 stability., cadherin switching and p120(ctn) signaling as important targets of GnRH function and as novel mediators of invasiveness and tumor progression in ovarian cancer., The altered expression of p120catenin isoforms in invasive breast cancer and, in our material, the decrease in p120 immunoexpression was significantly associated with poor outcome of disease., These results indicate an anti-inflammatory effect of p120 in bronchial epithelial cells, through its modulation of NF-kappaB signaling., Polymorphism of P120 catenin gene at T755G might be a risk factor for pancreatic carcinoma., Knockdown of HDPR1 gene enhanced the invasive ability of lung cancer cells, which was dependent on p120ctn and independent of beta-catenin, Study presents the crystal structure of p120 isoform 4A in complex with the JMD core region (JMD(core)) of E-cadherin., In endothelial cells, p120ctn has a transcription repression function through regulation of Kaiso, possibly as a cofactor with the transcription factor., Reduced p120ctn promoter activity, protein level, and mRNA message is found in lung cancer cells compared with noncancerous immortalized lung epithelial cells., Different expression patterns of E-cadherin and p120-catenin proteins can be helpful to distinguish infiltrating lobular carcinoma from ductal carcinoma of the breast., Data show that both Pak5 and constitutively active Pak4, the founding member of the Group B Paks, directly phosphorylate p120 in vitro., These results suggest that the transient increase of cytoplasmic p120-catenin may stimulate RhoGTPase activities and act as a switch for the morphological changes in ECs in response to shear stress., Data indicate that depletion of any of the cadherin-associated proteins, p120ctn, beta-catenin or alpha-catenin, is sufficient to disrupt adherens junctions in DU145 cells and increase migration and cancer cell invasion., Results demonstrate a novel and crucial function of p120-catenin in Wnt signaling and unveil additional points of regulation by this factor of beta-catenin transcriptional activity different of beta-catenin stability., p120 is required for maintaining VE-cadherin expression and transendothelial resistance independently of its NH(2) terminus and its role in regulating Rho., Increased delta-catenin expression is critical for maintenance of the malignant phenotype of lung cancer, making delta-catenin a candidate target protein for future cancer therapeutics., The degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin., P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin., The data provide evidence for the role of c-Crk proto-oncogene in transcriptional repression of p120ctn that further clarifies the mechanism by which this biochemical signal promotes metastasis in non-small cell lung cancer., the TGF-beta and p120-associated noncanonical beta-catenin pathways are important in pelvic lymph node metastasis in early-stage cervical cancer, p120-catenin isoform 3 regulates the nuclear export of Kaiso and promotes invasion in lung cancer cells via a phosphorylation-dependent mechanism., p120ctn Expression Is Lost or Reduced in Esophageal Cancer Tissues and Cell Linessuppressor gene., p120ctn functions to suppress transcription, which is an important and novel regulation in vascular endothelium, when released from E-cadherin by Wnt3a-stimulated phosphorylation, p120-catenin controls the activity of Kaiso, enhancing its binding to repressed promoters and relieving its inhibition of the beta-catenin-Tcf-4 transcriptional complex., Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin-ZO-1 interactions., p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance, we found that Numb directly interacted with p120 catenin, which is known to interact with E-cadherin and prevent its internalization, study presents evidence that in the cadherin-catenin complex alpha-catenin contributes to the binding strength of another catenin, p120, to the same complex; data suggest alpha-catenin-p120 contact within the cadherin-catenin complex can regulate cadherin trafficking, Dynamin 2/NPRAP colocalization and direct interaction in vivo, was investigated., p120 dynamically regulates Rho-GTPase activity at the E-cadherin complex through transient interaction with several of its up- and downstream effectors, including ROCK1, These data suggested that smoke-induced cell migration was mediated via an EGFR/Src-dependent signaling pathway in cells that expressed p120ctn, but upon loss of p120ctn, migration continued to occur via an alternative, EGFR/Src-independent pathway., Results suggest that p120ctn isoforms 1 and 3 up-regulate cyclin D1, and thereby cyclin E, resulting in the promotion of cell proliferation and cell cycle progression in lung cancer cells., Activation of E-cadherin induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain., This review summarizes the current findings about the influence of Rho GTPases on the formation and maintenance of adherens junction and discusses the involvement of p120 catenin on cell-cell adhesion and tumor cell migration. [review], Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition., P120ctn isoform 3A increased the invasiveness in all four cell lines., p120 overexpression inhibits neutrophil migration independently of an effect on RhoA or Rac and instead blocks migration by preventing VE-cadherin tyrosine phosphorylation and association of active Src with the VE-cadherin complex, S-nitrosation correlated with diminished abundance of beta-catenin and p120 at the adherens junction and with hyperpermeability., High cytoplasmic p120ctn expression is associated with thymoma., Identify MUC1-CT and p120ctn as important regulators of epithelial polarity and cell-cell adhesion during a smoke-induced epithelial mesenchymal transition-like process., FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression, results reveal the mechanistic basis by which p120 stabilizes cadherins and demonstrate that VE-cadherin endocytosis is crucial for endothelial cell migration in response to an angiogenic growth factor., P120ctn plays a pivotal role in the proliferation., Suggest pivotal role of miR-197 in the regulation of p120 catenin in invasive ductal adenocarcinoma., Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions., prostate cancer CWR22Rv-1 cells overexpressing delta-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay., the binding of VE-cadherin to p120 regulates adhesive contact area in a Rac1-dependent manner, Overexpression of delta-catenin reduces the expression of E-cadherin and alters the balance between E-cadherin and p120ctn, which in turn affects the formation of intercellular adhesions and promotes invasion and metastasis in Colorectal cancer., study demonstrated miR-145 targeted catenin delta-1, contributing to aberrant translocation of beta-catenin through impaired nuclear shuttling with p21-activated kinase 4; findings uncover a novel role of miR-145 in modulating intracellular translocation of beta-catenin on Wnt/beta-catenin signaling pathway, FoxC2 and p120ctn play important roles in the progression and prognosis of gastric cancer., Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting., p120ctn delocalization/loss of expression could be an independent prognostic marker in oral squamous cell carcinoma, Overexpression of NLBP promotes the cell proliferation of lung adenocarcinoma through interacting with p120ctn., Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium., expression and subcellular localization of p120-catenin and beta-catenin in oral carcinomas, Overexpression of HO-1 promotes Caco-2 cell proliferation and migration by targeting the CTNND1 gene., these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity, P120 catenin ARM domains 1, 3-5, and 8 mediate interactions between p120 catenin and MUC1., these results indicate that c-Src can enhance the oncogenic function of delta-catenin in prostate cancer cells, The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling., Data indicate that Kaiso protein participates in the regulation of beta-catenin mRNA expression by interacting with p120-catenin in the lung cancer cell lines., Transfection of in H1299 cells expressing low p120ctn levels., E-cadherin and P120 catenin cocktail immunostain can be used to differentiate ductal carcinoma in situ from lobular carcinoma in situ., our study supports the regulatory role of p120 in airway inflammation and reveals that p120 may modulate NF-kappaB signaling partially through RhoA., findings confirm that p38 and PAX2 are important for the Dvl-3 induced upregulation of p120ctn, We conclude that delta-catenin tends to overexpress in breast carcinoma and promotes the malignant phenotype, MiR-145 inhibits invasion of gastric cancer cells not only by down-regulating cytoplasmic catenin-delta1 expression but also by inducing the translocation of catenin-delta1, p120ctn down-regulation and EGFR overexpression are able to mimic human ESCC in a culture model, Enforced expression of miR-29s in gastric cancer cells inhibited cell invasion in vitro and in vivo by directly targeting CTNND1., results indicate an anti-inflammatory effect of p120 in bronchial epithelial cells through its modulation of NF-kappaB signaling depending on RhoA/ROCK pathway., C6orf106 promotes invasion in NSCLC cells. Finally, C6orf106 upregulates vimentin, and downregulates E-cadherin and P120ctn., localization of p120 catenin in the cytoplasm rather than the membrane correlates with poor prognosis in esophageal squamous cell carcinoma, uncovering a critical role for CTNND2 in neuronal development and an intimate connection to chromatin biology; data contribute to the understanding of the genetic architecture of autism, The expression, redistribution and disassociation of junction proteins in ventilator-induced lung injury were all restored with p120-catenin overexpression., Survival time of colorectal cancer patients with positive deltacatenin expression was shorter than that of patients with negative deltacatenin expression., Pro-Tumorigenic Phosphorylation of p120 Catenin is associated with Renal and Breast Cancer., the modulation of HPV-16 E6/E7 expression remarkably influenced cell proliferation, migration, and invasion, as well as the protein levels of E-cadherin and P-cadherin in cervical cell lines., p120ctn improves the BBB dysfunction and inflammatory responses induced by LPS through the inhibition of NF-kappaB activation., PLEKHA7 localization to adherens junctions is E-cadherin and p120 dependent., expression of E-cadherin, and p120 negatively correlated with the tumor differentiation of oral squamous cell carcinoma., Phosphorylation and isoform use in p120-catenin during development and tumorigenesis., expression of catenin-delta1 rescued the inhibitory effect of miR-409-3p on cell migration and invasion,
OFFICIAL_GENE_SYMBOL CTNND1,
SP_COMMENT alternative products:Experimental confirmation may be lacking for some isoforms, disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated., domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted., function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage., induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure., PTM:Phosphorylated., similarity:Belongs to the beta-catenin family., similarity:Contains 10 ARM repeats., subcellular location:Interaction with GLIS2 promotes nuclear translocation., subunit:Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2., tissue specificity:Expressed in vascular endothelium.,