Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
The Database for Annotation, Visualization and Integrated Discovery
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casein kinase 2 beta(CSNK2B) casein kinase 2 beta(CSNK2B) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6p21-p12, 6p21-p12|6p21.3, 6p21.3,
ENSEMBL_GENE_ID ENSG00000204435,
ENTREZ_GENE_ID 1460,
GENERIF_SUMMARY Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins., HIV-1 Rev transactivator, Response of cancer cells to molecular interruption of the CK2 signal., Characterization of CK2 holoenzyme variants with regard to crystallization, Transcriptional coordination of the genes encoding catalytic (CK2alpha) and regulatory (CK2beta) subunits of human protein kinase CK2., Consequences of CK2 signaling to the nuclear matrix., Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus, Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein, Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation., sequencing of full-length DNA encoding subunits in platelets and megakaryocytic cells, FGF-1 binds to both the catalytic alpha-subunit & to the regulatory beta-subunit of CK2.The presence of FGF-1 or FGF-2 was found to enhance the autophosphorylation of CK2 beta., results show that the Ring-H2 finger motif of CKBBP1 is necessary for efficient binding to CKIIbeta, as well as for optimal cell proliferation, microtubule-associated protein that confers microtubule stability in a phosphorylation-independent manner, Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies., CK2 phosphorylation of La can affect production of the translational machinery, These findings support the notion that CK2beta can act as a general modulator of remote docking sites in protein kinase--substrate interactions., In vitro phosphorylation of eIF2beta also pointed to Ser2 as a preferred site for CK2 phosphorylation, CK2 activity in Chinese Hamster Ovary (CHO) cells is entirely accounted for by the holoenzyme., there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17, hNopp140 serves as a negative regulator of CK2 and InsP(6) stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2, a stabilized form of CK2beta can be used to inhibit cell proliferation, protein kinase CK2 is involved in cell cycle regulation and indicate the mechanism by which CDC25A turnover might be regulated by Chk1 in the absence of DNA damage., There was a positive correlation between the expressions of CK2alpha and CK2beta in laryngeal squamous cell carcinoma., Further studies in transgenic mice and cultured cells suggest that cellular toxicity, including proteasomal dysfunction, increases casein kinase 2 activity, which results in elevated Ser129 alpha-syn phosphorylation., The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression., Transcript amounts of the subunits CK2alpha and CK2beta and holoenzyme CK2 activity in 34 muscle biopsies of human patients with different muscle pathologies, were determined., These findings support the view that CK2beta regulates various intracellular processes by modulating the activity of protein kinases that are distinct from CK2., Data show that these CK2-targeted motifs in MDC1 are required to mediate NBS1 association with chromatin-flanking sites of unrepaired DNA double-strand breaks., In epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions., presents unbound three-dimensional structure of a CK2beta construct that is fully capable of CK2alpha recruitment and quantify its affinity to CK2alpha thermodynamically, CK2beta is widely expressed in endometrial carcinoma , and suggest a role in cell proliferation and anchorage-independent cell growth, Casein kinase 2 phosphorylates human cytomegalovirus pUL84, and this interaction is required for oriLyt-dependent DNA replication., CK2-dependent phosphorylation controls the nuclear localization, aggregation and stability of ataxin-3., These studies support CK2beta as an important regulator of ALK-1 signaling and ALK-1-mediated functions in endothelial cells., These experiments indicate that casein kinase II phosphorylation of varicella-zoster virus open reading frame 63 S186 occurs in the nucleus and possibly identify an initial molecular event operative in virus reactivation., CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA., The Casein Kinase 2 (CK2) was identified as a binding and regulatory partner for Mitogen- and stress-activated protein kinase(MSK1)., analysis of interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2, Freshly isolated peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (n = 44) showed significantly higher levels of phosphorylated Akt1,PTEN, and casein kinase 2 than healthy persons (n = 8)., Threonine at amino acid (aa) 770 and serine at aa 854 to 855 of RIG-I are phosphorylated by casein kinase II (CK2) in the resting state of the cell and dephosphorylated when cells are infected by RNA virus., Identification of key residues on CK2alpha and CK2beta that play a cooperative role in CK2alpha/CK2beta binding and thermodynamics is important to further understand how these subunits interact in order to form a tetramer., CK2 enhances the protein level and activity of TTP via the modulation of the MKP-1-p38 MAPK signaling pathway; TGF-beta1 enhances the activity of CK2, Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility, The high expression of ck2beta in colorectal cancer is closely correlated to carcinogenesis and metastasis., Results provide an important role of CK2 in regulating nuclear ERK activities., An interaction of the adiponectin receptor 1 with the tetrameric complex and protein kinase CK2 as a key player in adiponectin signaling, is reported., A dysregulation of CK2beta expression might contribute to epithelial-to-mesenchymal-transition induction during cancer progression., C-terminal domain of PLD2 can regulate CKII by accelerating CKIIbeta degradation in HCT116 cells, Unbalanced expression of CK2 subunits may drive epithelial-to-mesenchymal transition, thereby contributing to tumour progression., The high expression of protein kinase CK2beta is closely related to the carcinogenesis and malignancy of esophageal cancer., Data indicate that protein S phosphorylation by casein kinase 1 (CK1) and casein kinase 2 (CK2) increased activated proten C cofactor activity., CK2alpha' exhibits a striking preference for caspase-3 phosphorylation in cells as compared to CK2alpha and that CK2beta exhibits the capacity to abolish caspase-3 phosphorylation, The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes., Asymmetric alpha2beta2 tetramers of casein kinase 2 are organized in trimeric rings that correspond to inactive forms of the enzyme. The new crystal structures presented here reveal the symmetric architecture of the isolated active tetramers., ARKL1 binds CK2beta through the KSSR motif and this involves a polyserine sequence resembling the CK2beta binding sequence in EBNA1., we propose that Foxc2 is functionally maintained in the cytoplasm of normal epithelial cells by CK2alpha/alpha'-mediated phosphorylation at serine 124, which is dependent on proper targeting of the holoenzyme via the CK2b regulatory subunit., CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and may have role in malignant B-cell growth., AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury., Data suggest that cryptochromes (Cry1 and Cry2) mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha)., Data suggest that cryptochromes mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha). [SYNOPSIS],
OFFICIAL_GENE_SYMBOL CSNK2B,
SP_COMMENT function:Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit., PTM:N-glycosylated., PTM:Phosphorylated by alpha subunit., similarity:Belongs to the casein kinase 2 subunit beta family., similarity:Contains 1 UPAR/Ly6 domain., subunit:Forms oligomer., subunit:Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,