Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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casein kinase 2 alpha 1(CSNK2A1) casein kinase 2 alpha 1(CSNK2A1) Related Genes Homo sapiens
CHROMOSOME 11, 20,
CYTOBAND 11p15.3, 20p13,
ENSEMBL_GENE_ID ENSG00000101266,
ENTREZ_GENE_ID 1457,
GENERIF_SUMMARY uPA-dependent VSMC adhesion is a function of selective Vn phosphorylation by the ectoprotein kinase CK2, Generation of mutants of CK2alpha which are dependent on the beta-subunit for catalytic activity, HIV-1 Rev transactivator, Protein kinase CK2, Response of cancer cells to molecular interruption of the CK2 signal., Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners, Characterization of CK2 holoenzyme variants with regard to crystallization, Transcriptional coordination of the genes encoding catalytic (CK2alpha) and regulatory (CK2beta) subunits of human protein kinase CK2., Consequences of CK2 signaling to the nuclear matrix., Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus, Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions., Unique activation mechanism of protein kinase CK2. The N-terminal segment is essential for constitutive activity of the catalytic subunit but not of the holoenzyme, Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B], FGF-1 binds to both the catalytic alpha-subunit and to the regulatory beta-subunit of CK2. FGF-1 & CK2 alpha are shown to interact in vivo. A correlation between the mitogenic potential of FGF-1 mutants & their ability to bind to CK2 alpha was observed., Data point to a particular role of the catalytic alpha and alpha' subunits of protein kinase CK2, which may be different from their roles in the holoenzyme., This protein is associated with the COP9 signalosome., HSF1 activation by heat is correlated with the thermal activation of nuclear CK2 and overexpression of CK2 activates HSF1, results indicate that protein kinase CKII may control IkappaBalpha and p27Kip1 degradation and thereby G1/S phase transition through the phosphorylation of threonine 10 within CKBBP1 protein, Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit, Evaluation of different pathways involved in death signaling suggest that the regulation of a critical proapoptotic step in HuH-7 cells by CK2alpha" is mediated by a JNK signaling cascade., structure activity relationship, might play an important role in vivo in regulating the function and transport activity of ABCA1 and possibly of other members of the ABCA subfamily, Utilizing a kinase-driven assay biochemical purification, the authors identified casein kinase II (CKII) from HeLa cell nuclear extract as a cellular phosphoprotein pp32 kinase., CK2 acts as an inhibitor of Cdk5 in the brain, Involvement of ubiquitous protein kinase CK2 in angiogenesis. Naturally derived CK2 inhibitors may be useful for treatment of proliferative retinopathies., CK2 regulates the DNA-binding ability of SSRP1 and that this regulation may be responsive to specific cell stresses., Data demonstrate that CK2alpha possesses sophisticated structural adaptations in favour of dual-cosubstrate specificity., constitutive phosphorylation by CK2 may be required for maximal activation of Akt/PKB, CK2 may have the capacity to differentially regulate U1 and U6 transcription even though SNAP(C) is universally utilized for human snRNA gene transcription, multiple kinases, including CK2 and GSK3beta, participate in PTEN phosphorylation and GSK3beta may provide feedback regulation of PTEN, Protein kinase CK2 is characterized by an extremely high stability that might be due to its association with other intracellular proteins, enhanced half-life or lower vulnerability towards proteolytic degradation., protein kinase CK2 is inactive in CCVs because of the fact that it is bound to the clathrin-coated vesicle (CCV) membrane via an interaction between phosphatidylinositol 4,5-bisphosphate in the CCV membrane and the active site in CK2, In vitro phosphorylation of eIF2beta also pointed to Ser2 as a preferred site for CK2 phosphorylation, CK2 may be involved in the regulation of cell cycle progression by associating with and phosphorylating a key molecule for translation initiation., casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia, CK2 is potentially a highly plausible target for cancer therapy., phosphorylation of the (T300) residue is dependent on CK2 and is a necessary and functional prerequisite for TSPY's transport into the nucleus, Dynamics of nucleolar reformation is ATP/GTP-dependent, sensitive to temperature, and creatin kinase-2 driven., CK2 regulates NKX3-1 in prostate cells., Based on its retinal localization, CK2 may be considered a new immunohistochemical astrocytic marker, and combination of CK2 inhibitors and octreotide may be a promising future treatment for proliferative retinopathies., role of CK2beta for cell survival and might allow the design of novel proapoptotic agents targeting this protein, CK2 activity in Chinese Hamster Ovary (CHO) cells is entirely accounted for by the holoenzyme., v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II., These studies suggested that CK2 might regulate SAG-SCF E3 ligase activity through modulating SAG's stability, rather than its enzymatic activity directly., CK2 has the potential to regulate Pol I transcription at multiple levels, in preinitiation complex (PIC) formation, activation, and reinitiation of transcription., CK2 plays an active role in NF-kappaB signaling in intestinal epithelial cell lines and may represent a possible target for intervention., CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin, CK2 is required for the assembly and cycling of Wnt-enhancer complexes in vivo., Results describe the 1.6 A resolution crystal structure of a fully active C-terminal deletion mutant of human CK2alpha liganded by two sulfate ions, and compare this structure systematically with representative structures of related CMGC kinases., extracellular phosphorylation of collagen XVII by ecto-CK2 inhibits its shedding by TACE and represents novel mechanism to regulate adhesion and motility of epithelial cells, Suggest a novel role of CK2 in breast cancer resistance to antiestrogens., cytotoxic adaptor function of NS1 was confirmed with fusion peptides, where the tropomyosin-binding domain of NS1 and CKIIalpha are physically linked, CK2 phosphorylation triggers an allosteric inhibition of the SNAP190 Myb DNA binding domain, EB2-mediated production of infectious EBV virions is regulated by CK2 phosphorylation at one or more of the serine residues Ser-55, -56, and -57, ABC50 N-terminal region interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2, The number of predicted CK2 sites correlated with the degree of in vitro and in vivo phosphorylation of NS5A by CK2. CK2-dependent phosphorylation of NS5A is heterogeneous among different HCV genotypes and clinical isolates., CK2 may be a key mediator for HDAC1 and HDAC2 activation under hypoxia in tumor cells, splicing activity is significantly influenced by the CK2-hPrp3p interaction, There was a positive correlation between the expressions of CK2alpha and CK2beta in laryngeal squamous cell carcinoma., Human herpesvirus 6Binduces p53 Ser392 phosphorylation by an atypical pathway independent of CK2 protein and p38 kinases., The complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin is studies in comparison with with a previously published complex structure of emodin and maize CK2alpha., CK2-mediated phosphorylation of TRF1 plays an important role in modulating telomere length homeostasis by determining the levels of TRF1 at telomeres, Protease activated receptor 1 activation of platelet is associated with an increase in protein kinase CK2 activity, CK2 is tightly associated with TAFII250 and is the principal activity responsible for TAFII250-mediated phosphorylation of Mdm2., Studies in yeast and in human cells demonstrate that the different forms of CK2 interact with a large number of cellular proteins., Transcript amounts of the subunits CK2alpha and CK2beta and holoenzyme CK2 activity in 34 muscle biopsies of human patients with different muscle pathologies, were determined., CK2 involvement in the phenomenon of the drug resistance was investigated., Casein kinase II activity is increased by the binding of haptoglobin 1-1-hemoglobin to CD163., CK2 activity was investigated both in vitro and in cultured cells by using anti-[pSer13]-Cdc37 antibody., These data identify a key post-translational mechanism that controls PML protein levels in cancer cells and suggest that CK2 inhibitors may be beneficial anti-cancer drugs., These results suggest that one of the modes of CK2-mediated modulation of apoptotic activity is via its impact on cellular inhibitors of apoptosis proteins., A crystal of a C-terminally truncated variant of human CK2alpha to which two molecules of the inhibitor 5,6-dichloro-1-beta-D-ribo-furanosyl-benzimidazole (DRB) are bound, is analyzsed., CK2 binds to the NHE3 C terminus and stimulates basal NHE3 activity by phosphorylating a separate single site on the NHE3 C terminus, CK2 may be involved in the regulation of cell cycle progression through the phosphorylation of a key molecule for translation initiation and of nuclear substrates upon activation of CK2 by itself., CK2 catalyzes the phosphorylation of tyrosine residues in mammalian cells., KIF5C, a member of the kinesin 1 heavy chain family, is a substrate for protein kinase CK2., Mitoxantrone is a strong inhibitor of recombinant human protein kinase CK2 in vitro. Apoptosis induced by mitoxantrone in HL-60 cells has no correlation to intracellular CK2 activity., InsP(6) specifically binds to CK2alpha and disrupts the interaction between CK2alpha and Nopp140 with an IC(50) value of 25 microM, thereby attenuating the Nopp140-mediated repression of CK2 activity., study presents unbound three-dimensional structure of a CK2beta construct that is fully capable of CK2alpha recruitment and quantify its affinity to CK2alpha thermodynamically, DNA methylation-dependent down-regulation of transcription factors Sp1, Ets1 and NF-kappaB might be involved in silencing of the CKII alpha and CKII alpha' genes during cellular senescence., DNA methylation-dependent down-regulation of transcription factors Sp1, Ets1 and NF-kappaB might be involved in silencing of the CKII alpha and CKII alpha' genes during cellular senescence.[CKII alpha'], PrP protein can bind to protein kinase CK2 both in native and recombinant forms in vitro., Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia., Ikaros is controlled by the CK2 and PP1 pathways and that a balance between these two signal transduction pathways is essential for normal cellular function and for the prevention of malignant transformation., CK2beta dimer stabilizes the glycine-rich loop in the extended active conformation known from the majority of CK2alpha structures., protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization, Extracellular protein kinase CK2 binds to the extracellular domain of NRP1 which is also phosphorylated by CK2 both in vitro and in vivo., CK2-dependent phosphorylation controls the nuclear localization, aggregation and stability of ataxin-3., These studies reveal multisite phosphorylation of IGFBP-3 that both positively and negatively regulate its apoptotic potential., The constitutive phosphorylation of XRCC1 in the chromatin and its DNA damage-induced recruitment to the nuclear matrix are critical for foci formation., PDCD5 is phosphorylated in vitro by both CK2alpha subunit and by the CK2., Data show that decreasing CK2 activity increases intracellular hydrogen peroxide, creating an intracellular environment conducive for death execution., Protein kinase CK2 plays an important role in the radiosensitivity of the nasopharyngeal carcinoma cells., This study shows that the activation of the p53-p21(Cip1/WAF1) pathway acts as a major mediator of cellular senescence induced by CKII inhibition., CK2 is the kinase responsible for phosphorylating Pax3 and oncogenic fusion protein Pax3-FOXO1 at serine205 in proliferating mouse primary myoblasts and in a variety of translocation-containing alveolar rhabdomyosarcoma cell lines., These results highlight serines 11 and 92 as new players in Snail1 regulation and suggest the participation of CK2 and PKA in the modulation of Snail1 functionality., MSK1 and MSK2 are differentially regulated by CK2 during the UV response and that MSK2 is the major protein kinase responsible for the UV-induced phosphorylation of p65 at Ser(276) that positively regulates NF-kappaB activity in MDA-MB-231 cells, The EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and tumor cell invasion., Protein kinase CK2alpha plays an important role in the proliferation and invasion of nasopharyngeal carcinoma., CK-II-dependent PPARgamma phosphorylation at Ser16 and Ser21 is necessary for CRM1/Ran/RanBP3-mediated nucleocytoplasmic translocation of PPARgamma., CK2-mediated pathways reversibly regulate purinosome assembly, The interface between apoptosis initiation and execution by determining caspase-8 activation, Bid cleavage and mitochondrial engagement (onset of mitochondrial depolarisation) in individual HeLa, was analysed., These data show that Tax-1 is phosphorylated in vitro by the pleiotropic human serine/threonine kinase CK2 at three residues, Ser-336, Ser-344 and Thr-351, close to and within its C-terminal PDZ-binding motif., CK2 plays a crucial role in the ATR-dependent checkpoint pathway through its ability to phosphorylate Ser-341 and Ser-387 of the Rad9 subunit of the 9-1-1 complex., Data show that the CSNK2A1P gene is a functional proto-oncogene in human cancers and its functional polymorphism appears to degrade PML differentially in cancer cells., Herein, the authors have identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as two kinases of CLIP-170 and mapped S195 and S1318 as their respective phosphorylation sites., The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed., These results indicate that CK2 has an important role in the modulation of DNA-PKcs activity and its phosphorylation status providing important insights into the mechanisms by which DNA-PKcs is regulated in vivo., Reduced Casein Kinase II enhances chemosensitivity to gemcitabine in pancreatic cancer., an interaction between EBNA1 and the host CK2 kinase is crucial for EBNA1 to disrupt PML bodies and degrade PML proteins., Protein kinase CK2 inhibition results in activation of the receptor mediated apoptosis pathway via the ER stress response highlight the importance of CK2 inhibitors., The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo., Data presented the crystal structures of CK2alpha in complex with CX-4945 and adenylyl phosphoramidate at 2.7 and 1.3 A, respectively., Protein kinase CK2alpha plays an important role in the apoptosis of human laryngeal carcinoma cells possibly by decreasing bcl-2/Bax., Sox4 stimulates ss-catenin activity through induction of CK2., CK2 is a central regulator of topo I hyperphosphorylation., The effect of a mutation in the follicle-stimulating hormone receptor in a protein kinase-CK2 consensus site that alters degradation of follicle-stimulating hormone (FSH) is studied., Overexpression of nuclear CK2alpha can be a useful marker for predicting the outcome of patients with colorectal cancer., Findings identify CK2 as a crucial protein involved in the formation and clearance of aggresomes, and hence in cell viability in response to misfolded protein stress., Data suggest that phospho-Ser81 progesterone receptors (PR) provides a platform for casein kinase 2 recruitment and regulation of selected PR-B target genes., we report that the kinase CK2 is a novel interaction partner of JAKs and is essential for JAK-STAT activation, Twist expression can be regulated at the post-translational level through phosphorylation by CK2, which increases Twist stability in response to IL-6 stimulation, CK2 down regulation facilitates TNF-alpha-mediated chondrocyte death through apoptosis and autophagy, A novel mechanism in the development of cardiac hypertrophy is demonstrated when transgenic CK2alpha1 activates histone deacetylase 2 (HDAC2) via phosphorylating HDAC2 serine394., Human papillomavirus type 38 E7 protein promotes keratinocyte proliferation by negatively regulating actin cytoskeleton fiber formation through the CK2-MEK-ERK-Rho pathway and by inhibiting eEF1A and its effects on actin cytoskeleton remodeling., CK2alpha plays an essential role in the development of colorectal cancer., CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation, Results provide an important role of CK2 in regulating nuclear ERK activities., The Arabidopsis co-chaperone protein p23 is a CK2 target., Persistence of high CK2 level in R (resistant)-CEM, as opposed to S (sensitive)-CEM, is accompanied by the presence of an immunospecific form of Cdc37., In hsCK2alpha' an open conformation of the interdomain hinge/helix alphaD region that is critical for ATP-binding is found corresponding to an incomplete catalytic spine. In contrast hsCK2alpha often adopts the canonical, PKA-like version of the catalytic spine., The nuclear localization signal sequence-dependent Grp94 kinase in the cell lysate is identical with CK2., CK2 appears to play an important role in the biology of B-cell chronic lymphocytic leukemia., Inhibition of CK2 activity by three different inhibitors led to a down-regulation of the level of cdc25C., An interaction of the adiponectin receptor 1 with the tetrameric complex and protein kinase CK2 as a key player in adiponectin signaling, is reported., These data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2alpha., The primary mechanisms by which apigenin kill multiple myeloma cells is by targeting the trinity of CK2-Cdc37-Hsp90., our results demonstrate that EEF1D is a bona fide physiological CK2 substrate for CK2 phosphorylation, CKII downregulation induces p53 stabilization by negatively regulating SIRT1 deacetylase activity during senescence, the pleotropic Serine/Threonine kinase CK2 is implicated in the regulation of IL-6 expression in a model of inflammatory breast cancer., identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha phosphorylation, proximal to a caspase 7 cleavage site, The unique flexibility of the CK2alpha catalytic subunit in the hinge region, the p-loop and the beta4 beta5 loop, show that there is no clear-cut correlation between the conformations of these flexible zones., The human adenovirus type 5 E1B protein is phosphorylated by protein kinase CK2., CK2 regulates vaccinia virus dissemination and actin tail formation., The the CK2 catalytic subunit CK2alpha is modified by O-linked beta-N-acetyl-glucosamine (O-GlcNAc) on Ser347, proximal to a cyclin-dependent kinase phosphorylation site (Thr344)., The connection with proliferation and migration, as well as the activation of ZIP7 by CK2, a kinase that is antiapoptotic and promotes cell division, Results suggest CK2 as a novel regulator of the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) cascades and HSP90 function in myeloma cells and offer the groundwork to design novel combination treatments for this disease., Protein kinase CK2 co-localizes with gamma-H2AX to sites of genetic lesions and modulation of its expression levels affects the cellular DNA damage response., A new crystal structure of the CK2 holoenzyme was determined that plays an essential role in the formation of inactive polymeric assemblies., Unbalanced expression of CK2 subunits may drive epithelial-to-mesenchymal transition, thereby contributing to tumour progression., ATF4 is involved in ER stress signalling through the AARE, which further supports our finding that CK2 inhibition provokes an amino acid induced response pathway., CK2alpha-NCoR cascade selectively represses the transcription of IP-10 and promotes oncogenic signaling in human esophageal cancer cells., Phosphorylation of S284 by protein kinase CK2 significantly decreases nuclear targeting of IPMK in HEK-293 cells., that high intracellular PKCK2 activity confers anoikis resistance on esophageal cancer cells by inducing E- to N-cadherin switching., The inhibition of CK2alpha down-regulates Hh/Gli signaling and subsequently reduces stem-like side population in human lung cancer cells., Recovery of RNA polymerase III transcription from the glycerol-repressed state, CK2 and human malignant tumor, analysis of crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands, A CD5-CK2 signaling pathway represents a major signaling cascade initiated by CD5 that regulates the threshold of T cell activation and T helper (Th) cell differentiation., our findings identify CK2 as a novel component of the autophagic machinery and underline the potential of its downregulation to kill glioblastoma cells by overcoming the resistance to multiple anticancer agents., Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2., the present results show that miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively promote cellular senescence through the p53-p21(Cip1/WAF1) pathway by CKII downregulation-mediated ROS production in HCT116 cells., Casein kinase 2alpha inhibition decreases the total protein level of beta-catenin and cell growth., CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity., Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62, Brd4 association with p53 is modulated by casein kinase II (CK2)-mediated phosphorylation of a conserved acidic region in Brd4, These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking., Data indicate that by altering the scaffold of CK2 inhibitors to obtain selective inhibitors of DYRK1A and PIM1., Studies indicate systematic platforms for studying CK2 inhibitors., crystal structure of CK2alpha with a 13-meric cyclic peptide derived from the C-terminal CK2beta segment, Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner., PI3K is involved in CKII inhibition-mediated cellular senescence in HCT116 cells., Data indicate that protein S phosphorylation by casein kinase 1 (CK1) and casein kinase 2 (CK2) increased activated proten C cofactor activity., CK2alpha' exhibits a striking preference for caspase-3 phosphorylation in cells as compared to CK2alpha and that CK2beta exhibits the capacity to abolish caspase-3 phosphorylation, Enzyme inhibition studies and mutational analyses demonstrated that protein kinase CK2-catalyzed phosphorylation of HDAC1 and -2 is crucial for the dissociation of these two enzymes., inhibition of CK2alpha down-regulates Notch1 signalling and subsequently reduces a cancer stem-like cell population in human lung cancer cells, These results identify casein kinase 2 as a new target of PD-1 and reveal an unexpected mechanism by which PD-1 decreases PTEN protein expression while increasing PTEN activity, thereby inhibiting the PI3K/Akt signaling axis., The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes., These findings identify CK2 as an upstream activating kinase of PAK1, providing a novel mechanism for PAK1 activation., HspA1A also interacts with CK2 and enhances the kinase activities of CK2 during DNA repair., knockdown of CK2alpha expression by siRNA restores the sensitivity of resistant LAMA84 cells to low imatinib concentrations., upregulation of VEGF in primary RPE cells was blocked by a chemical inhibitor of protein kinase CK2 known to suppress induction of ATF4 and VEGF by OxPLs, The CSNK2A1 gene has gene dosage gains in glioblastoma, and is significantly associated with the classical glioblastoma subtype., miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9., crystal structure of CK2alpha with 21 loci of alternative conformations, including a niacin, 19 ethylene glycols and 346 waters, was determined at 1.06 A resolution to an Rwork of 14.0%, Asymmetric alpha2beta2 tetramers of casein kinase 2 are organized in trimeric rings that correspond to inactive forms of the enzyme. The new crystal structures presented here reveal the symmetric architecture of the isolated active tetramers., The CFTR Ser511 can be phosphorylated by the combined action of tyrosine kinases and CK2 and disclose a new mechanism of hierarchical phosphorylation where the role of the priming kinase is that of removing negative determinants., CK2 activity is inhibited by Nopp140 and reactivated by inositol hexakisphosphate by competitive binding at the substrate recognition site of CK2., Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP., These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA., Protein kinase CK2 alpha is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly., Phosphorylation by CK2 impairs Par-4 proapoptotic functions., LSD1 is a novel substrate of protein kinase CK2alpha., Data suggest that overexpression of CK2a (casein kinase 2, alpha) in liver promotes oncogenesis by mediating EGF/EGFR- (epidermal growth factor/EGF receptor)-induced HDAC2 (histone deacetylase 2) expression in hepatocarcinogenesis., the inhibition of protein kinase CK2 transiently inhibits cell proliferation through the induction of G1 cell cycle arrest and attenuation of protein synthesis by phosphorylating eIF2 alpha., HCV core up-regulates HAMP gene transcription via a complex signaling network that requires both SMAD/BMP and STAT3 pathways and CK2 involvement, Overexpression of CK2 (alpha, alpha' or beta subunits) by transient transfection resulted in decreased Stat3 Ser-727 phosphorylation., we characterize CK2 as an essential component of the Jak/STAT pathway, Genetic suppression of CK2alpha enhances the apoptosis induced by cisplatin in laryngeal carcinoma cells., Study revealved that RPL22 binds CK2alpha in lung cancer cells., protein kinase CK2 has a role in bone marrow stromal cell-fueled multiple myeloma growth and osteoclastogenesis, CK2 alpha is an independent prognostic indicator for gastric carcinoma patients and is involved in tumorigenesis by regulating the phosphorylation of DBC1., CagA(+) H. pylori upregulates cellular invasiveness and motility through casein kinase 2., These findings highlight the potential role of dysregulated miRNA expression regulated by CK2 in breast cancer., Results show that CK2alpha may have an important role in brain tumor-initiating cell maintenance through the regulation of beta-catenin in glioblastoma., CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer., Over-expressed CK2alpha positively regulate Hh/Gli1 signaling in human mesothelioma., JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells., CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and may have role in malignant B-cell growth., our findings provide new insights on the potential relevance of the CK2-mediated phosphorylation of B23/NPM in cancer cells, revealing at the same time the potentialities of its pharmacological manipulation for cancer therapy, CDK11 and CK2 expression are individually essential for breast cancer cell survival, including TNBC., Data show that casein kinase 2 (CK2)-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1., These phosphopeptides include altogether 69 phosphoresidues, a large proportion of which (almost 50%) are generated by CK2, while the others do not conform to the CK2 consensus, CK2-phosphorylation of eIF3j at Ser127 promotes the assembly of the eIF3 complex, a crucial step in the activation of the translation initiation machinery., Overall results, confirm that a balance of hydrophobic and electrostatic interactions contribute predominantly relative to possible intermolecular halogen/hydrogen bonding ,in binding of halogenated benzotriazoles to the ATP-binding site of hCK2alpha, Casein kinase 2-mediated phosphorylation of Hsp90beta and stabilization of PXR is a key mechanism in the regulation of MDR1 expression., Phosphorylation of KCNQ2 and KCNQ3 anchor domains by protein kinase CK2 augments binding to AnkG., ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12-ATG5-ATG16L1 complex and autophagy induction, There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation., The combination treatment of TRAIL and the CK2 inhibitor decreased p65 nuclear translocation... the treatment of a sub-dose of TRAIL, downregulation of CK2, using both genetic and pharmacological approaches ., CK2-mediated phosphorylation of ARC contributed to chemotherapy resistance by inhibiting DOX induced apoptosis; combining DOX with CK2 inhibitor could induce apoptosis of cancer cells synergistically by down-regulating the phosphorylation of ARC, High casein kinase II expression is associated with B-cell acute lymphoblastic leukemia., Inhibition of ecto-CK2 by K137-E4 is accompanied by a slower migration of cancer cells as judged by wound healing assays, CK2-increased ECE-1c protein stability is related to augmented migration and invasion of colon cancer cells, shedding light on a novel mechanism by which CK2 may promote malignant progression of this disease., Data suggest that cryptochromes mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha). [SYNOPSIS], Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis., Protein kinase CK2 expression predicts relapse survival in ERalpha dependent breast cancer, and modulates ERalpha expression in vitro., This study report increased levels of CK2 in the hippocampus and temporal cortex of AD patients compared to non-demented controls.,
OFFICIAL_GENE_SYMBOL CSNK2A1,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily., similarity:Contains 1 protein kinase domain., subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.,
casein kinase 2 alpha 2(CSNK2A2) casein kinase 2 alpha 2(CSNK2A2) Related Genes Homo sapiens
CHROMOSOME 16,
CYTOBAND 16q21,
ENSEMBL_GENE_ID ENSG00000070770,
ENTREZ_GENE_ID 1459,
GENERIF_SUMMARY Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners, Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus, Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein, Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B], FGF-1 binds to both the catalytic alpha-subunit & to the regulatory beta-subunit of CK2. FGF-1 & CK2 alpha are shown to interact in vivo. A correlation between the mitogenic potential of FGF-1 mutants & their ability to bind to CK2 alpha was observed., physiological control of G-protein regulation by phosducin-like protein seems to involve phosphorylation by CK2 and alternative splicing of the regulator, Data point to a particular role of the catalytic alpha and alpha' subunits of protein kinase CK2, which may be different from their roles in the holoenzyme., Ets motifs play, in cooperation with Sp motif clusters, a central role in regulating CK2alpha' gene transcription., Results identified the motor neuron protein KIF5C as a new binding partner for the protein kinase CK2alpha'., The CK2 alpha' phosphorylates APRIL and therefore is responsible for the regulation of the nucleocytoplasmic translocation of CD83 mRNA., Data presented the crystal structures of CK2alpha in complex with CX-4945 and adenylyl phosphoramidate at 2.7 and 1.3 A, respectively., A thorough investigation of CK2alpha identifies key energetic hot spots on the surface of CK2alpha and their thermostability and catalytic activity in comparison to the wild type subunit., Results provide an important role of CK2 in regulating nuclear ERK activities., In hsCK2alpha' an open conformation of the interdomain hinge/helix alphaD region that is critical for ATP-binding is found corresponding to an incomplete catalytic spine. In contrast hsCK2alpha often adopts the canonical, PKA-like version of the catalytic spine., Lack of DNA-PKcs is accompanied by an increase in the protein level of one of the catalytic isozymes of protein kinase CK2, i.e., CK2alpha' and a concomitant increase in CK2 activity., CK2alpha' exhibits a striking preference for caspase-3 phosphorylation in cells as compared to CK2alpha and that CK2beta exhibits the capacity to abolish caspase-3 phosphorylation, CSNK2A2 phosphorylates telomeric repeat binding factor 1 and plays an important role for regulation of telomere length., Data suggest casein kinase II (CK2) inhibitors indeno[1,2-b]indole-9,10-dione, which also inhibited the breast cancer resistance protein ABCG2, might be a good therapeutic strategy to improve anticancer drug efficiency., Over-expressed CK2alpha positively regulate Hh/Gli1 signaling in human mesothelioma., we propose that Foxc2 is functionally maintained in the cytoplasm of normal epithelial cells by CK2alpha/alpha'-mediated phosphorylation at serine 124, which is dependent on proper targeting of the holoenzyme via the CK2b regulatory subunit., CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and may have role in malignant B-cell growth., We conclude that this class of chimeric peptides, in addition to altering some properties of CK2 holoenzyme, affects several other cellular targets, causing profound perturbations of cell biology, results suggest that CK2alpha might play an oncogenic role in hepatocellular carcinoma,
OFFICIAL_GENE_SYMBOL CSNK2A2,
SP_COMMENT catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily., similarity:Contains 1 protein kinase domain., subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,
casein kinase 2 beta(CSNK2B) casein kinase 2 beta(CSNK2B) Related Genes Homo sapiens
CHROMOSOME 6,
CYTOBAND 6p21-p12, 6p21-p12|6p21.3, 6p21.3,
ENSEMBL_GENE_ID ENSG00000204435,
ENTREZ_GENE_ID 1460,
GENERIF_SUMMARY Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins., HIV-1 Rev transactivator, Response of cancer cells to molecular interruption of the CK2 signal., Characterization of CK2 holoenzyme variants with regard to crystallization, Transcriptional coordination of the genes encoding catalytic (CK2alpha) and regulatory (CK2beta) subunits of human protein kinase CK2., Consequences of CK2 signaling to the nuclear matrix., Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus, Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein, Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation., sequencing of full-length DNA encoding subunits in platelets and megakaryocytic cells, FGF-1 binds to both the catalytic alpha-subunit & to the regulatory beta-subunit of CK2.The presence of FGF-1 or FGF-2 was found to enhance the autophosphorylation of CK2 beta., results show that the Ring-H2 finger motif of CKBBP1 is necessary for efficient binding to CKIIbeta, as well as for optimal cell proliferation, microtubule-associated protein that confers microtubule stability in a phosphorylation-independent manner, Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies., CK2 phosphorylation of La can affect production of the translational machinery, These findings support the notion that CK2beta can act as a general modulator of remote docking sites in protein kinase--substrate interactions., In vitro phosphorylation of eIF2beta also pointed to Ser2 as a preferred site for CK2 phosphorylation, CK2 activity in Chinese Hamster Ovary (CHO) cells is entirely accounted for by the holoenzyme., there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17, hNopp140 serves as a negative regulator of CK2 and InsP(6) stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2, a stabilized form of CK2beta can be used to inhibit cell proliferation, protein kinase CK2 is involved in cell cycle regulation and indicate the mechanism by which CDC25A turnover might be regulated by Chk1 in the absence of DNA damage., There was a positive correlation between the expressions of CK2alpha and CK2beta in laryngeal squamous cell carcinoma., Further studies in transgenic mice and cultured cells suggest that cellular toxicity, including proteasomal dysfunction, increases casein kinase 2 activity, which results in elevated Ser129 alpha-syn phosphorylation., The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression., Transcript amounts of the subunits CK2alpha and CK2beta and holoenzyme CK2 activity in 34 muscle biopsies of human patients with different muscle pathologies, were determined., These findings support the view that CK2beta regulates various intracellular processes by modulating the activity of protein kinases that are distinct from CK2., Data show that these CK2-targeted motifs in MDC1 are required to mediate NBS1 association with chromatin-flanking sites of unrepaired DNA double-strand breaks., In epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions., presents unbound three-dimensional structure of a CK2beta construct that is fully capable of CK2alpha recruitment and quantify its affinity to CK2alpha thermodynamically, CK2beta is widely expressed in endometrial carcinoma , and suggest a role in cell proliferation and anchorage-independent cell growth, Casein kinase 2 phosphorylates human cytomegalovirus pUL84, and this interaction is required for oriLyt-dependent DNA replication., CK2-dependent phosphorylation controls the nuclear localization, aggregation and stability of ataxin-3., These studies support CK2beta as an important regulator of ALK-1 signaling and ALK-1-mediated functions in endothelial cells., These experiments indicate that casein kinase II phosphorylation of varicella-zoster virus open reading frame 63 S186 occurs in the nucleus and possibly identify an initial molecular event operative in virus reactivation., CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA., The Casein Kinase 2 (CK2) was identified as a binding and regulatory partner for Mitogen- and stress-activated protein kinase(MSK1)., analysis of interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2, Freshly isolated peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (n = 44) showed significantly higher levels of phosphorylated Akt1,PTEN, and casein kinase 2 than healthy persons (n = 8)., Threonine at amino acid (aa) 770 and serine at aa 854 to 855 of RIG-I are phosphorylated by casein kinase II (CK2) in the resting state of the cell and dephosphorylated when cells are infected by RNA virus., Identification of key residues on CK2alpha and CK2beta that play a cooperative role in CK2alpha/CK2beta binding and thermodynamics is important to further understand how these subunits interact in order to form a tetramer., CK2 enhances the protein level and activity of TTP via the modulation of the MKP-1-p38 MAPK signaling pathway; TGF-beta1 enhances the activity of CK2, Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility, The high expression of ck2beta in colorectal cancer is closely correlated to carcinogenesis and metastasis., Results provide an important role of CK2 in regulating nuclear ERK activities., An interaction of the adiponectin receptor 1 with the tetrameric complex and protein kinase CK2 as a key player in adiponectin signaling, is reported., A dysregulation of CK2beta expression might contribute to epithelial-to-mesenchymal-transition induction during cancer progression., C-terminal domain of PLD2 can regulate CKII by accelerating CKIIbeta degradation in HCT116 cells, Unbalanced expression of CK2 subunits may drive epithelial-to-mesenchymal transition, thereby contributing to tumour progression., The high expression of protein kinase CK2beta is closely related to the carcinogenesis and malignancy of esophageal cancer., Data indicate that protein S phosphorylation by casein kinase 1 (CK1) and casein kinase 2 (CK2) increased activated proten C cofactor activity., CK2alpha' exhibits a striking preference for caspase-3 phosphorylation in cells as compared to CK2alpha and that CK2beta exhibits the capacity to abolish caspase-3 phosphorylation, The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes., Asymmetric alpha2beta2 tetramers of casein kinase 2 are organized in trimeric rings that correspond to inactive forms of the enzyme. The new crystal structures presented here reveal the symmetric architecture of the isolated active tetramers., ARKL1 binds CK2beta through the KSSR motif and this involves a polyserine sequence resembling the CK2beta binding sequence in EBNA1., we propose that Foxc2 is functionally maintained in the cytoplasm of normal epithelial cells by CK2alpha/alpha'-mediated phosphorylation at serine 124, which is dependent on proper targeting of the holoenzyme via the CK2b regulatory subunit., CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and may have role in malignant B-cell growth., AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury., Data suggest that cryptochromes (Cry1 and Cry2) mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha)., Data suggest that cryptochromes mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like protein) and thus inhibit Bmal1-Ser90 phosphorylation by Ck2a (casein kinase 2alpha). [SYNOPSIS],
OFFICIAL_GENE_SYMBOL CSNK2B,
SP_COMMENT function:Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit., PTM:N-glycosylated., PTM:Phosphorylated by alpha subunit., similarity:Belongs to the casein kinase 2 subunit beta family., similarity:Contains 1 UPAR/Ly6 domain., subunit:Forms oligomer., subunit:Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,