Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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CREB binding protein(CREBBP) CREB binding protein(CREBBP) Related Genes Homo sapiens
CYTOBAND 16p13.3,
GENERIF_SUMMARY substrate specificity; structure activity relationship, The PHD type zinc finger is an integral part of the CBP acetyltransferase domain, Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation., IL-6-inducible expression of the hAGT promoter is mediated by physical association of the COOH terminus of STAT3 with p300/CBP, the recruitment of which targets histone acetylation and results in chromatin remodeling., overexpression of CBP is detected from the very early stages of laryngeal carcinogenesis, suggesting that CBP may play a role in malignant transformation of precancerous laryngeal lesions, role in acetylation of beta-catenin, Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene., A missense mutation has been identified in codon 1175 of CREBBP in a mild case of Rubinstein-Taybi syndrome., HIV Tat is a general inhibitor of histone acetylation by cellular HATs and for the CREB-binding protein (CBP), it induces a substrate selectivity, CBP enhances tumor necrosis alpha-induced cell death in rheumatoid synoviocytes, role in transcriptional control of the inflammatory response, is co-expressed with CREB and CBP in extravillous cytotrophoblasts, revealing the in vivo relevance of this transactivation pathway, results suggest that all-trans-retinoic acid and retinoic acid receptors regulate growth arrest of human mammary epithelial cells and modulate CBP/p300 protein expression, arginine methylation represents an important mechanism for modulating CBP co-activator transcriptional activity, Oct-1 potentiates CREB-dependent cyclin D1 transcriptional activity by a phospho-CREB and CREB binding protein-independent mechanism, CBP has a role in regulating 5-aminolevulinate synthase gene expression via the AP-1 complex in human tumor cells, structurally distinct modes of recognition of the KIX domain of this protein by Jun and CREB, interaction of CREB-binding protein with EWS selectively activates hepatocyte nuclear factor 4-mediated transcription, The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, there is a crosstalk between lysine acetylation and arginine methylation on chromatin, recruitment to pp90RSK regulates cAMP response element-binding protein activity which is negatively affected by ERK phosphorylation, The KID-interacting domain of human coactivator CREB-binding protein (CBP) is the CBP domain that is targeted by HIV-1 Tat during HIV-1 propagation., PHD finger mutations cause a loss of CBP acetyltransferase activity, in human mammary epithelial cells, CBP/p300 were both modulated by an all-trans-retinoic acid (ATRA) signaling pathway and were required for a normal response to ATRA, deletion of the CBP bromo- and C/H3 domains eliminates stimulation of nucleosomal histone deacetylase activity in vitro and transcriptional coactivation by EBV Zta in transfected cells, Loss of CREBBP was not statistically significant selection in cancer cells stratified by various criteria for the concordant loss of EP300 and CREBBP., CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation., p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP, Estrogen receptor-alpha represses human GnRH receptor gene transcription via an indirect mechanism involving Creb-binding protein., CBP-induced acetylation of AFX is a novel modification mechanism by which AFX keeps the transcriptional activity mitigating in the nucleus, Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma, The site of the KID-interacting (KIX) domain of CBP that recognizes c-Jun and mixed lineage leukemia MLL proteins is identified as the same site that binds HIV-1 Tat protein., the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382, Novel heterozygous deletion in CREBBP in Rubinstein-Taybi syndrome patient results in the loss of exon 30., activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP., activation of CREB-binding protein and inhibition of MAPK has a role in cAMP-dependent protein kinase type I regulation of ethanol-induced cAMP response element-mediated gene expression, CBP acetylation controls HNF6 protein stability, effect of CREB-binding protein on inhibition of Smad-mediated transcriptional activation by K-bZIP was examined, E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells, important functions in coordinated cell cycle progression, Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment, Both TAZ domains of CREB-binding proteins CBP and p300 in the presence of stoichiometric concentrations of zinc adopt a well-defined structure in solution in the absence of binding partners., Mutations and deletions of the CBP gene is associated with lung cancer, glutamine rich and bZIP domains stabilize CREB binding to chromatin, In 92 patients, we were able to identify a total of 36 mutations in CBP. By using multiple ligation-dependent probe amplification, we found not only several deletions but also the first reported intragenic duplication in a patient with RSTS., HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas, Smad-binding peptide aptamers can be developed to selectively inhibit TGF-beta-induced gene expression., In conclusion, this research supports FSCN1 as a novel marker of NT2 neuronal differentiation and the possible role of CBP in its regulation., The interaction of fibroblast growth factor receptor-1, The identification of CBP inactivating mutations in conjunction with disruption of the second CBP allele strongly suggests that CBP is a tumour suppressor gene that contributes to ovarian tumorigenesis in humans., We aimed to determine the rate of point mutations and other small molecular lesions in true Rubinstein-Taybi syndrome and possible mild variants, by using genomic DNA sequencing of the CREBBP gene., CBP and PCAF coactivators mediate ERK1 gene expression at both the transcriptional and post-transcriptional level, the histone chaperone SET regulates CBP-mediated transcription, The interaction between CtBP and CBP is functionally important and leads to impairment of histone H3 acetylation by CBP at specific lysine residues (Lys9, Lys14, and Lys18) in a dose-dependent and NADH-dependent manner., GCMa acetylation is mediated by CBP, which stimulates GCMa transcriptional activity through cyclic AMP/protein kinase A signaling, CREB elements on the COX-2 promoter were involved in the gene transcription event., Suppression of CBP in human mammary epithelial cells results in loss of reconstituted extracellular matrix-mediated growth control and apoptosis and loss of laminin-5 alpha 3-chain expression., both p300 and CBP increase ATF4 transcriptional activity, arginine methylation of CBP is required for IFN-gamma induction of MHC-II. A kinetic analysis shows that CIITA, CARM1, and H3-R17 methylation all precede CBP loading on the MHC-II promoter during IFN-gamma treatment., Recruitment of Daxx following SUMO modification represents a previously undescribed mechanism in modulating CREB-binding protein (CBP) transcriptional potential., ATM is required for CREB phosphorylation in UV irradiation-damaged cells., study proposes a new mechanism by which estrogen receptors and retinoic acid receptors regulate BRCA1-mediated DNA repair by means of CBP, analysis of a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein, Expression of a dominant negative CREB (S133A) blocked PDB/TG-dependent induction of both COX-2 and mPGES-1 promoters. Decreased CREB expression by siRNA blocked PDB/TG-dependent expression of COX-2 and mPGES-1 mRNA., binding of p53 serves to modify simian virus 40 large T antigen (SV40 LT) by targeting CREB binding protein and p300 binding to direct the acetylation of SV40 LT, MOZ-TIF2 associates with the RARbeta2 promoter in vivo, resulting in altered recruitment of CBP/p300, aberrant histone modification, and down-regulation of the RARbeta2 gene, Stat3-mediated p100 processing to p52 requires activation of Stat3 by the acetyltransferase activity of cAMP-response element-binding protein (CREB)-binding protein (CBP)/p300, CREB phosphorylation and CRE-regulated gene expression are activated by kinases., Acid-induced NOX5-S expression and H(2)O(2) production were significantly inhibited by removal of extracellular Ca(2+) and by knockdown of CREB using CREB small interfering RNA in a tumor cell line., CREB activation is involved in up-regulation of Fc gammaRIIA expression in myeloid lineages., PEA3 and c-Jun stimulate synergistically the HER2/neu gene transcription with p300, histone deacetylase inhibitors not only inhibit deacetylase activity but also stimulate active NF-kappaB transcription and cell survival through signaling pathways involving Akt and increased p300 acetyltransferase activity, Our results provide evidence for novel functional interactions between the chromatin modification enzyme CBP and nuclear transport proteins in mammalian cells., A high detection rate of CREBBP mutations in Rubinstein-Taybi Syndrome patients is confirmed by this Italian study which also attests one of the highest microdeletion rate (16%) documented so far., first report of a direct interaction between N-CoR and CBP, and suggests that the role of N-CoR in mediating transcriptional events may be more complex than previously anticipated, hypothesized that HSV-1 ICP0 recruits activated IRF-3 & CBP/p300 to nuclear structures, away from host chromatin; this leads to inactivation & accelerated degradation of IRF-3, resulting in reduced transcription of IFN-beta & inhibition of host response, Large deletions including several exons are a relatively frequent cause of RTS; MP/LC is an effective method for detecting these deletions., Role for the CREB binding protein includes the modulation of chromatin structure and function during DNA metabolic events as well as for transcription., analysis of MYST3-CBP fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias, Coexpression of Etsl and CBP induced a synergistic activation of the parathyroid hormone-related protein P3 promoter only in the tumorigenic cell line., CBP/p300 has an evolutionarily conserved role as a buffer regulating TCF-beta-cat/Arm binding., Our results suggest that phosphorylation of CBP by IKKalpha regulates the CBP-mediated crosstalk between NF-kappaB and p53 and thus may be a critical factor in the promotion of cell proliferation and tumor growth., mice expressing a dominant-negative CREB transgene (M-ACREB mice) exhibited a dystrophic phenotype along with reduced myocyte enhancer 2 activity., P13-K/Akt-dependent activation of CREB protein in Jurkat T leukemia cells treated with TRAIL is reported., CBP and TRAP220 was diminished by the overexpression of a MED25 NR box deletion mutant, and by treatment with MED25 siRNA, finding implicates CBP as one of the causative genes for the trisomy 16p13 syndrome, and indicates this is a contiguous gene syndrome, results indicate that the genetic polymorphism of the CBP, which is one of the essential factors exerting the biological effects of glucocorticoids, may affect susceptibility to steroid-induced osteonecrosis in patients after renal transplantation, These results provide evidence for a model in which Tax and pCREB bind distinct surfaces of KIX for effective CBP/p300 recruitment to the HTLV-1 promoter., CREB binding to the HIF-1 responsive elements in PAI-1 promoter mediates the glucagon effect in the liver, Cyclosporine impairs CREB DNA binding activity., Therefore, these data support the hypothesis that CREB plays a critical role in the regulation of Bcl-2 expression in TCS-induced Hela cell death., High frequency of mosaic CREBBP deletions is associated with Rubinstein-Taybi syndrome, KLF4 might function as an activator or repressor of transcription depending on whether it interacts with co-activators such as p300 and CREB-binding protein or co-repressors such as HDAC3., Data demonstrates that CBP dosage is a critical regulator of gene-specific signal integration between the ER- and NFkappaB-signaling pathways., CREB binding proten affects Proteinase-activated receptor-2 and cyclooxygenase 2 expression., These data reveal that phosphorylation of CREB is not sufficient for CBP/p300 recruitment and transcriptional activation., the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways., This study provides the first insight into the mechanisms that control basal expression of human SNF2L gene., The study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization., CBP is a novel binding partner of XAF1, and the interaction between XAF1 and CBP and their functional consequence were mediated by adaptor-related protein complex 1., Three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) bound to peptides derived from histone acetylation sites., Phosphorylation deficient c-jun was less able to recruit PCAF to AP-1 sites., These results reveal that HDAg interacts with cellular transcription factor YY1 and its associated acetyltransferases CBP and p300 in a large nuclear complex, which in turn modulates the replication of HDV RNA., Results show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity of p300/CBP., MUC5AC gene expression are mediated by a complex regulatory cascade controlling interactions between CREB and c-Ets1 that bind to a promoter element in the MUC5AC gene enhancing MUC5AC gene transcription., HTLV-1 Tax interferes with IFN-alpha-induced JAK-STAT pathway by competition with STAT2 for CBP/p300 binding., CBP duplications could result in the trisomy 16p13 phenotype., in patients with femoral head osteonecrosis, The synergistic index between the ABCB1 and CBP genes was >1.00 (1.99), revealing the presence of an interaction, PML (acute promyelocytic leukemia) nuclear bodies are nuclear sites involved in the ubiquitin-dependent degradation of CBP., Brucella controls host defenses by impairing macrophage responses to IFNgamma induced STAT1-CBP/P300 association., Results demonstrated that aberrant interaction of PHOX2B mutants with CBP and/or an interfering effect of certain PHOX2B mutants may be the critical mechanism to impair synergistic activation, thereby contributing to the phenotypes of CCHS., demonstrate that the histone acetyl transferase CBP (also known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, The presence of an identified CREBBP gene abnormality was possibly related to the motor difficulties through impaired motor skills learning., Data support a model in which the NHD region of Pygopus is required to augment transcriptional activation by a mechanism that includes both transcriptional activation and histone acetylation resulting from the recruitment of the CBP., CBP-mediated post-translational N-glycosylation of BRCA2., Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein, Data show that cytoplasmic p300/CBP E4 activities ubiquitinate and destabilize p53, while physically separate nuclear p300/CBP activities, such as p53 acetylation, activate p53., Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome., Here we present an 8-month-old boy with varicella meningoencephalitis, RTS, and a de novo deletion of the CREBBP gene of two base pairs at position 201-202 in exon 2, c. 201 202delT., This study demonstrated an association between two polymorphisms in the CBP gene and cognitive function in an elderly population., The aim of this genome-wide assay was to identify rearrangements that might underlie Rubinstein-Taybi syndrome-like phenotypes in patients who were negative at Fluorescence in situ hybridization analyses of the CREBBP and EP300 regions., Results describe the role of CREBBP re-arrangements during neuronal differentiation., DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding, CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein, CREBBP variable expression (family 1) and somatic mosaicism (family 2) contribute to the phenotypic variability of Rubinstein-Taybi syndrome., Data report the highest detection rate of CREBBP mutations (76.9%) in Rubinstein-Taybi syndrome patients to date, of which ten are predicted to be pathogenic and three critical for histone acetyltransferase activity., Exon coverage microarray platform detected intragenic deletions, TNFalpha and IFNgamma synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-kappaB, and the transcriptional coactivator CREB-binding protein., p300 and CBP are implicated in regulation of ER-beta activity and cellular migration in prostate cancer., Data show that the binding rate between domains of CREB and CREB binding protein was initially accelerated and subsequently dramatically decreased as the strength of the nonnative hydrophobic interactions increased., BCL11B might play a role in anti-apoptosis in T-ALL cells through up-regulation of its downstream genes BCL2L1 and CREBBP., investigation of role of CBP and gamma catenin in regulation of transcription of survivin, Downregulation of CREBBP, seen in the intestine of celiac disease children, was normalized after gluten-free diet treatment., results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin's lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms, analysis of a cohort of 71 diagnosis-relapse cases and 270 acute leukaemia cases that did not relapse found 18.3% of relapse cases had sequence or deletion mutations of CREBBP, in estrogen-regulated gene programming, the acetyltransferase CREB-binding protein (CBP) is specifically and exclusively methylated by the coactivator-associated arginine methyltransferase (CARM1) in vivo, CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands, The results of this study suggested that rs3025684 polymorphism may be a possible risk factor for developing addiction., CBP/p300 and SIRT1 were recruited to histone gene promoters in an NPAT-dependent manner, knockdown of which affected histone acetylation on histone gene promoters and histone gene transcription., we identified different mutations at the CREBBP locus in nine patients with Rubinstein-Taybi syndrome that illustrate different grades of the clinical severity in the spectrum of the syndrome, CBP is required for regulation of BIRC3, and this may be due to its ability to acetylate histones around the estrogen response element and promote estrogen receptor access to the gene, thereby leading to potentiation of BIRC3 gene expression., The nuclear receptor co-activator binding domain (NCBD) of CREBBP selectively recruits transcription co-activators during formation of the transcription preinitiation complex. Three of four ligand-bound states are accessible to the ligand-free NCBDs., Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells., CREBBP and EP300 mutations are not major pathogenetic mechanisms of myeloproliferative neoplasms, mutant p53 elevates expression of genes capable of enhancing cell proliferation, motility, and tumorigenicity by inducing acetylation of histones via recruitment of CBP and STAT2 on the promoters causing CBP-mediated histone acetylation, The rsults of this study suggested the lack of influence of SNPs under investigation in the present study on the susceptibility to schizophrenia and on the response to antipsychotics., our findings show that the E2A proteins are acetylated at specific residues as a consequence of lysine acetyltranferases(CBP, p300 and PCAF ) recruitment, TGF-beta1/beta-catenin/CBP-mediated pro-EMT signaling pathway., analysis of angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1, SRCAP is an SNF2-related chromatin-remodeling factor that serves as a coactivator for CREB-binding protein (CREBBP, better known as CBP, the major cause of Rubinstein-Taybi syndrome [RTS])., Rigorous genetic analysis of the CREBBP and EP300 genes using DNA sequencing and multiple ligation-dependent probe amplification (MLPA) revealed no causative mutation in this boy., The results of this study suggested that the single nucleotide polymorphisms of CREBBP do not influence diagnosis and treatment response in patients with major depressive disorder and bipolar disorder., We present the first evidence that the portion of E2A proteins found within the oncogenic fusion protein E2A-PBX1 and including the transcriptional activation domains can enhance the HAT activity of CBP/p300, Screening for mutations in the CREBBP gene from cases of high hyperdiploid (HD) childhood acute lymphoblastic leukemia resulted in an overall frequency of somatic CREBBP aberrations in HD ALL relapse cases of 63%., Overexpression of CBP/p300 in conjunction with E2A results in enhancement of E2A-induced histone acetylation, germline transcription, and immunoglobulin (Ig)kappa light chain rearrangement., Data indicate six new CBP mutations identified in Brazilian patients with Rubinstein-Taybi syndrome., The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling., The study confirms that CREBBP is the critical gene involved in the duplication 16p13.3 syndrome., CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes., report of a Moroccan family with 2 children with Rubinstein-Taybi syndrome and apparently unaffected parents; molecular studies showed a heterozygous mutation c.4361T>A in exon 26 of the CREBBP gene in the affected siblings; neither parents, nor the healthy brother, carry this mutation in hematologic cells, Results show that Akt regulates acetyltransferase activity through CBP phosphorylation, which may contribute to tumorigenesis., HSV-1 VP16 is able to block the production of IFN-beta by inhibiting NF-kappaB p65 activation and interfering with IRF-3 to recruit its coactivator CBP, which may be important to the early events leading to HSV-1 infection., In the title., Characterize the structure of the transition state of the binding-induced folding in the reaction between the KIX domain of the CREB-binding protein and the transactivation domain of c-Myb., germline deletion in CREBBP gene is associated with Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma., Cryptic microdeletion of the CREBBP gene from t(1;16) (p36.2;p13.3) as a novel genetic defect causing Rubinstein-Taybi syndrome., Sp1 may regulate the expression of CD59, whereas CREB-binding protein (CBP)/p300 bridge NF-kappaB and CREB, which functions as an enhancer-binding protein to induce the up-regulation of CD59 during in lipopolysaccharide (LPS)-triggered complement activation., study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A., provide evidence for the existence of a functional ternary complex containing TDG, CBP and activated RARalpha, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1, show how CBP and PTEN interact to mediate tumor suppression in the prostate, establishing a central role for histone modification in the etiology of prostate cancer, The combination of p300 and CBP expression may be useful in identifying patients with increased risks of cancer recurrence of small cell lung cancer., TDG, as a new coactivator, promotes beta-catenin/TCFs transactivation and functionally cooperates with CBP in canonical Wnt signaling., EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression., First study of Korean Rubinstein-Taybi syndrome patients indicating distinct geographic distribution of CREBBP mutations, It is associated with episodic memory performance., CBP contributes to the upregulation of human telomerase reverse transcriptase expression and tumor growth, and overexpression of CBP predicts poor prognosis in human lung cancers., MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation., 42 new CREBBP mutations were reported in 46 Rubinstein-Taybi syndrome patients., GR tau1c phosphorylation could promote CBP recruitment and enhance activation function 1 activity., destabilization of p300/CBP by downregulation of iASPP expression levels appears to represent a molecular mechanism that contributes to chemoresistance in melanoma cells., CREBBP mutation in follicular lymphoma progenitors is associated with decreased MHC class II expression., Characterization of 14 novel deletions underlying Rubinstein-Taybi syndrome, these data suggest that CBP/p300 are promising therapeutic targets across multiple subtypes in acute myeloid leukemia., CREBBP mutations are associated with recurrence in hyperdiploid acute lymphoblastic leukemia., Conclude that the CBP/beta-catenin complex is a core component of the MDR1 transcriptional "enhancesome" in neoplasms., WNT/beta-catenin signaling does not affect nuclear translocation of the RelA subunit of NF-kappaB or its association with CBP (also known as CREBBP), these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 by CBP for immediate-early Per induction and the resetting of the circadian clock., Disruption of beta-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair., RFPL3 and CBP have roles in upregulating hTERT activity and promoting lung cancer growth, Kaposi's sarcoma-associated herpesvirus vIRF4 targets the beta-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing virus replication., Case Report, Computational simulations were used to understand how phosphorylation affects the structure of the p53 terminal transactivation domain in complex with the CBP TAZ2 domain., Intrinsic protein disorder plays a prominent role in the function and interactions of the transcriptional co-activators CBP and p300. (Review),
OMIM_DISEASE Rubinstein-Taybi syndrome,
SP_COMMENT catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., disease:Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription., disease:Defects in CREBBP are a cause of Rubinstein-Taybi syndrome (RSTS) [MIM:180849]. RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies., domain:The KIX domain mediates binding to HIV-1 Tat., function:Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes., online information:P300/CBP entry, PTM:Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., PTM:Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX., similarity:Contains 1 bromo domain., similarity:Contains 1 KIX domain., similarity:Contains 1 ZZ-type zinc finger., similarity:Contains 2 TAZ-type zinc fingers., subunit:Found in a complex containing NCOA2; NCOA3; IKKA; IKKB and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with phosphorylated CREB1. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax and p30II. Interacts with HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with ZCCHC12 (By similarity). Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX (By similarity). Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter.,