Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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SSX family member 2 interacting protein(SSX2IP) SSX family member 2 interacting protein(SSX2IP) Related Genes Homo sapiens
CYTOBAND 1p22.3,
GENERIF_SUMMARY Nuclear protein SS2IP interacts with cancer-related protein SSX2 and the human homologue of a Ras-like GTPase interactor, RABIN3., data shows that SSX2IP is affected in two ways that relate to the cell cycling of acute myeloid leukaemia cells, results showed that SSX2IP promotes the development and metastasis of hepatocellular carcinoma and contributes to the drug resistance of hepatoma cells, The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone., SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication. On SSX2IP knockdown, the centriolar satellites become stuck at the microtubule minus end near the centrosome., In airway epithelial cells, measles virus spread requires the nectin-4/afadin complex and is based on cytoplasm transfer between columnar cells., Knockdown of Wdr8 or hMsd1/SSX2IP displayed very similar mitotic defects, in which spindle microtubules became shortened and misoriented., Studied afadin in complex with beta-catenin in glomeruli and in cultured mesangial cells. Found expression of afadin at mesangial intercellular junctions was greatly decreased in mesangial proliferative nephritis in rats & patients w/glomerulonephritis., This study determined the crystallographic structure of human Afadin in complex with LGN.,
SP_COMMENT domain:Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2., function:Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin., subcellular location:Not found at cell-matrix AJs., subunit:Interacts with afadin and alpha-actinin (By similarity). Interacts with SSX2 and SSX3. Does not interact with SSX1 and SSX4., tissue specificity:Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.,