Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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fibroblast growth factor receptor substrate 2(FRS2) fibroblast growth factor receptor substrate 2(FRS2) Related Genes Homo sapiens
GENERIF_SUMMARY FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors, FRS2 has a role in fibroblast growth factor-2-induced signaling, findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point, FRS2-dependent SRC activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity, Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2., an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains, a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling., Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling., Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways., The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha., Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts, Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma., Patient with pigmentation disorders and vitiligo show decreased expression of mRNA., a novel signaling network containing FRS2, CAP and flotillin-1, Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas., These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development., The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling., Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications., Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib., They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.,
SP_COMMENT function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., PTM:Phosphorylated on tyrosine residues upon stimulation by NGF., PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination., sequence caution:Translated as stop., similarity:Contains 1 IRS-type PTB domain., subcellular location:Cytoplasmic, membrane-bound., subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11., tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,