Database for Annotation, Visualization and Integrated Discovery 2.1
National Institute of Allergy and Infectious Disease
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WAS protein family member 3(WASF3) WAS protein family member 3(WASF3) Related Genes Homo sapiens
GENERIF_SUMMARY patient with ganglioneuroblastoma carries an apparently balanced t(1, the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets, during megakaryocytic differentiation, platelets expressed WAVE-1 and WAVE-2, whereas WAVE-3 expression was hardly to be detected. WAVE-3 expression was not changed by the differentiation, all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly, WAVE3-mediated migration in MDA-MB-231 cells via lamellipodia formation is activated downstream of PI3K and induced by PDGF, The WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility., the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3., WAVE3 is pivotal in controlling the invasiveness of prostate cancer cells., Studies identified a novel mechanism for the regulation of WAVE3 expression in cancer cells, which controls the invasive properties and morphology of cancer cells associated with their metastatic potential., The study also identifies a critical role for WAVE3, downstream of miR-31, in the invasion-metastasis cascade., coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-kappaB signaling, which in turn regulates MMP-9 production facilitating invasion., HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein., demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors, MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa., WAVE3-depleted breast cancer cells move more slowly but more persistently on a 2-dimensional matrix. They typically only show one lamellipod. WAVE3 appears to have no role in driving invasiveness. Lamellipodial persistence is not crucial in 3-dimensions., increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer, ZEB1/2 upregulation by WASF3 results from downregulation of KISS1, leading to the release of inhibition of nuclear factor (NF)kappaB by IkappaBalpha, these results define a novel signaling network whereby JAK2/STAT3 signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility., Upregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cells., miR-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3., We show that WAVE3-mediated modulation of NFkappaB is required for invadopodia formation as well as MMP9 expression and activity that are needed for cancer cells to degrade the ECM, WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail., WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells., stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles,
SP_COMMENT domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain., function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton., similarity:Belongs to the SCAR/WAVE family., similarity:Contains 1 WH2 domain., subunit:Binds actin and the Arp2/3 complex., tissue specificity:Expressed in ovary and brain.,