DAVID Bioinformatics 6.7
The Database for Annotation, Visualization and Integrated Discovery
DAVID Bioinformatics Resources 6.8
Laboratory of Human Retrovirology and Immunoinformatics (LHRI)

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publication
LHRI Publications
Google Scholar 2018 | 2017 | 2016 Last updated April 2018
A DNA repair protein, Ku70, translocates after DNA virus infection
A DNA repair protein, Ku70 (Green) and STING (Red) co-localize in the cytoplasm after DNA virus infection

2018 Publications
D. Poudyal, A. Herman, J. Adelsberger, J. Yang, X. Hu, Q. Chen, M. Bosche, B. T. Sherman, and T. Imamichi. A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression. Scientific Reports 8(1):900. (2018). [PubMed]

2018 Presentations
H. Sui, J.Yang, X. Hu, Q. Chen, HC. Lane and T. Imamichi. siRNAs Containing a Unique 5-nucletide Motif Act as a Quencher of IFI16-mediated DNA Sensing in Innate Immune Response. Cytokine 2018; (Boston, MA), October 27-30, 2018. Abst. P247.
S. Laverdure, Z. Wang, K. Nagashima, HC. Lane and T. Imamichi. IL-27 triggers autophagy in macrophages via a mTOR and LC3-Independent Manner. Cytokine 2018; (Boston, MA), October 27-30, 2018. Abst. P043.
S. Laverdure, Z. Wang, K. Nagashima, HC. Lane and T. Imamichi. IL-27 induces autophagy during monocyte-to-macrophage differentiation through a novel LC3-independent pathway. Oral and Poster presentation. Immunology 2018; (Austin, TX), May 4-8. Abst. 164.7.
H. Sui, H.C. Lane and T. Imamichi. Human Ku70, a nuclear protein associated with non-homologous end-joining (NHEJ) pathway of DNA repair, is translocated to the cytosol upon exogenous DNA stimulation and serves as a DNA sensor to induce IFN-lambda 1 (Type-III IFN) via a STING dependent manner. Keystone Symposia. Cells vs. Pathogen: Intrinsic Defenses and Counter defenses; (Monterey, California), USA, March 23-26, 2018. Abs. 1048.
D. Poudyal, A. Herman, J. Adelsberger, J. Yang, X. Hu, Q. Chen, M. Bosche, B. T. Sherman, and T. Imamichi. A novel IL-27-stimulated microRNA, hsa-miR-6852 (miR SX4) induces necrosis in cervical cancer cells by downregulating the FoxM1 expression by unconventional microRNA pathway. Keystone Symposia. Noncoding RNAs: Form, Function, Physiology;(Keystone, Colorado), USA, Feb 25-Mar 1, 2018.

2017 Publications
H. Sui, M. Zhou, H. Imamichi, X. Jiao, B.T. Sherman, H.C. Lane, T. Imamichi. STING is an Essential Mediator of the Ku70-Mediated Production of IFN-Λ1 in Response to Exogenous DNA. Science Signaling 10(488):eaah5054. (2017). [PubMed]
X. Hu, Q. Chen, B. Sowrirajan, M. Bosche, T. Imamichi, and B.T. Sherman. Genome-Wide Analyses of Microrna Profiling in Interleukin-27 Treated Monocyte-Derived Human Dendritic Cells Using Deep Sequencing: A Pilot Study. International Journal of Molecular Sciences 18(5). (2017). [PubMed]
S.P. Babu, Y.K. Chen, S. Bonne-Annee, J. Yang, I. Maric, T.G. Myers, T.B. Nutman, and A.D. Klion. Dysregulation of Interleukin 5 Expression in Familial Eosinophilia. Allergy. (2017). [PubMed]
B. Sowrirajan, Y. Saito, D. Poudyal, Q. Chen, H. Sui, S.S. DeRavin, H. Imamichi, T. Sato, D.B. Kuhns, N. Noguchi, H.L. Malech, H.C. Lane, and T. Imamichi. Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-Derived Macrophages and Dendritic Cells by Induction of P47phox. Scientific Reports 7:43441. (2017). [PubMed]

2017 Presentations
Y. Saito, B. Sowrirajan, D. Poudyal, N. Noguchi, HL. Malech, HC. Lane and T. Imamichi. Interleukin-27 Induces p47phox in Monocyte-derived Macrophages and Dendritic cells and Enhances the Potential of Reactive Oxygen Species Generation. Abstract presented at the Society for Redox Biology and Medicine 2017; 2017 November 29 - December 2; Baltimore, MD. Abs 321. [https://doi.org/10.1016/j.freeradbiomed.2017.10.334]
T. Izumi, D. Poudyal, J. Yang, X. Hu, M. Bosche, Q. Chen, W. Bruchey, R.G. Zamat, B.T. Sherman, H.C. Lane, and T. Imamichi. IL-27-inducible novel microRNA, hsa-mir-7705, predominantly elicits IFN-alpha from human monocyte-derived macrophages in a structure and sequence dependent manner. Poster presented at the 5th Annual Meeting of the International Cytokine & Interferon Society; 2017 October 29 - November 2; Kanazawa, Japan. Poster Abs. Mo-P11-12.
H. Sui, X. Hu, B.T. Sherman, H.C. Lane, and T. Imamichi. siRNA with a Unique 5-Nt Motif Potently Suppresses IFI16-Mediated Innate Immune Response to Intracellular DNA. Poster presented at the 5th Annual Meeting of the International Cytokine & Interferon Society; 2017 October 29 - November 2; Kanazawa, Japan. Poster Abs. Tu-P4-14.
X. Hu, Q. Chen, B. Sowrirajan, M. Bosche, T. Imamichi and B. T Sherman. MicroRNA Expression Profiling and Novel MicroRNA discovery in Interleukin-27 Treated Monocyte-derived Human Dendritic Cell. Poster presented at the 7th Genomics & Big Data Summit; 2017 September 26-27; San Diego, CA.
X. Jiao, H. Imamichi, T. Rehman, R. Nahar, R.L. Dewar H. C. Lane, T. Imamichi and B.T. Sherman. Self-Tuning Spectral Clustering for Full-length Viral Quasispecies Reconstruction with PacBio Long Reads. Poster presentation at the Proceedings of ACM-BCB; 2017 August 20-23; Boston, MA.
B. Sowrirajan, J. Yang, J. Adelsberger, M. Bosche, Q. Chen, C. Watkins, T.Izumi, H. Clifford Lane, and T. Imamichi. Interleukin-27 (IL-27) differentiates monocytes into HIV resistant dendritic cells: Identification of ANKRD22 as a novel inducible host restriction factor. Oral presentation at the 42nd annual meeting on Retroviruses; 2017 May 22-26; Cold Spring Harbor, NY.
T. Izumi, D. Poudyal, Q. Chen, X. Hu, BT. Sherman, and T. Imamichi. The Antiviral Mechanism of a Novel MicroRNA, miR 7705 in Macrophage induced by IL-27 Treatment. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
T. Rehman, A. Khan, H. Highbarger, P. Burbelo, B. Sherman, X. Hu, T. Imamichi, J. Metcalf , J. Beigel, C. Lane, M. Baseler, and RL. Dewar. A New Method to Test for Zika Virus? Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
H. Sui, M. Zhou, H. Imamichi, H. C. Lane and T. Imamichi. Identification of STING as an essential adaptor of Ku70 to initiate cytosolic DNA or DNA virus-mediated IFN-Λ1 innate immune response. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
X. Hu, Q. Chen, B. Sowrirajan, M. Bosche, T. Imamichi and BT. Sherman. Identification of Novel miRNAs and miRNA Expression Profiling in Interleukin-27 Treated Monocyte-derived Human Dendritic Cells. Poster presented at the Spring Research Festival at NCI-Frederick; 2017 May 2-3; Fort Detrick, Frederick, MD.
D. Poudyal, Q. Chen, JW. Adelsberger, J. Yang, RL. Homung, HC. Lane, T. Imamichi. A DNA- and RNA- binding protein, Y-Box Binding Protein-1 (YB-1) is a novel host required factor in CD4 T cells regulated by post-translational modification by Interleukin-27 (IL-27). Poster presented at the Keystone Symposia, Modeling Viral Infections and Immunity; 2017 May 1-4; Estes Park, Colorado.
H. Sui, M. Zhou, H. Imamichi, H. C. Lane and T. Imamichi. Identification of STING as an essential adaptor of Ku70-medited IFN-Λ1 induction in sensing intracellular DNA. Poster presented at the Keystone Symposia, Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease (X5); 2017 March 19-23; Banff, Alberta Canada.

2016 Publications
S. Swaminathan, J. Qiu, A.W. Rupert, Z. Hu, J. Higgins, R.L. Dewar, R. Stevens, C.A. Rehm, J.A. Metcalf, B.T. Sherman, M.W. Baseler, H.C. Lane, and T. Imamichi. Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation. PLoS One 11:e0167091. (2016). [PubMed]
L. Ma, C. Raley, X. Zheng, G. Kutty, E. Gogineni, B.T. Sherman, Q. Sun, X. Chen, T. Skelly, K. Jones, R. Stephens, B. Zhou, W. Lau, C. Johnson, T. Imamichi, M. Jiang, R. Dewar, R.A. Lempicki, B. Tran, J.A. Kovacs, and D.W. Huang. Distinguishing Highly Similar Gene Isoforms with a Clustering-Based Bioinformatics Analysis of Pacbio Single-Molecule Long Reads. BioData Mining 9:13. (2016). [PubMed]
J. Yang, NN. Diaz, J. Adelsberger, X. Zhou, R. Stevens, A. Rupert, J.A. Metcalf, M. Baseler, C. Barbon, T. Imamichi, R. Lempicki, and L.M. Cosentino. The Effects of Storage Temperature on PBMC Gene Expression. BMC Immunology 17:6. (2016). [PubMed]
L. Ma, Z. Chen, D.W. Huang, G. Kutty, M. Ishihara, H. Wang, A. Abouelleil, L. Bishop, E. Davey, R. Deng, X. Deng, L. Fan, G. Fantoni, M. Fitzgerald, E. Gogineni, J.M. Goldberg, G. Handley, X. Hu, C. Huber, X. Jiao, K. Jones, J.Z. Levin, Y. Liu, P. Macdonald, A. Melnikov, C. Raley, M. Sassi, B.T. Sherman, X. Song, S. Sykes, B. Tran, L. Walsh, Y. Xia, J. Yang, S. Young, Q. Zeng, X. Zheng, R. Stephens, C. Nusbaum, B.W. Birren, P. Azadi, R.A. Lempicki, C.A. Cuomo, and J.A. Kovacs. Genome Analysis of Three Pneumocystis Species Reveals Adaptation Mechanisms to Life Exclusively in Mammalian Hosts. Nature Communications 7:10740. (2016). [PubMed]
T. Yoshimura, T. Imamichi, J.M. Weiss, M. Sato, L. Li, A. Matsukawa, J.M. Wang, Induction of Monocyte Chemoattractant Proteins in Macrophages Via the Production of Granulocyte/Macrophage Colony-Stimulating Factor by Breast Cancer Cells. Frontiers in Immunology 7:2. (2016). [PubMed]
D.W. Huang, C. Raley, M.K. Jiang, X. Zheng, D. Liang, M.T. Rehman, H.C. Highbarger, X. Jiao, B. Sherman, L. Ma, X. Chen, T. Skelly, J. Troyer, R. Stephens, T. Imamichi, A. Pau, R.A. Lempicki, B. Tran, D. Nissley, H.C. Lane, and R.L. Dewar. Towards Better Precision Medicine: Pacbio Single-Molecule Long Reads Resolve the Interpretation of HIV Drug Resistant Mutation Profiles at Explicit Quasispecies (Haplotype) Level. Journal of Data Mining in Genomics & Proteomics 7: . (2016). [PubMed]

2016 Presentations
H. Sui, M. Zhou, X. Jiao, H. Imamichi, B.T. Sherman, H.C. Lane, and T. Imamichi. STING Is an Indispensable Adaptor in DNA Via Ku70-Mediated IFN-Λ1 Signalling Pathway. Poster presented at the Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2); 2016 May 8-12; Dresden, Germany.
B.T. Sherman, J.H. Beigel, X. Hu, J. Qiu, M. Bosche, J. Yang, R.A. Lempicki, H.C. Lane, R.T. Davey Jr., and T. Imamichi. Gene Expression Profiles Associated with a Recombinant Vesicular Stomatitis Virus Ebola Vaccine. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
J. Qiu, S. Swaminathan, A.W. Rupert, Z. Hu, J. Higgins, R.L. Dewar, R. Stevens, Q. Chen, C.A. Rehm, J.A. Metcalf, M.W. Baseler, B.T. Sherman, H.C. Lane, and T. Imamichi. Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
X. Jiao, T. Rehman, Q. Chen, H. Imamichi, R.L. Dewar, H.C. Lane, T. Imamichi, and B.T. Sherman. A Workflow for Viral Quasi-Species Analysis with Pacbio Long Reads. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.
X. Hu, Q. Chen, B. Sowrirajan, H.C. Lane, T. Imamichi, and B.T. Sherman. Genome-Wide Identification of Novel Micrornas in Human Monocyte-Derived Dendritic Cells. Poster presented at the Spring Research Festival; 2016 May 3-4; Fort Detrick, Frederick, MD.




 Please cite Nature Protocols 2009; 4(1):44 & Nucleic Acids Res. 2009;37(1):1 within any publication that makes use of any methods inspired by DAVID.
                          

        

                 
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